CN104187100A - Application of N-carbamylglutamic acid to promoting sexual development of replacement gilts - Google Patents
Application of N-carbamylglutamic acid to promoting sexual development of replacement gilts Download PDFInfo
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- CN104187100A CN104187100A CN201410408660.3A CN201410408660A CN104187100A CN 104187100 A CN104187100 A CN 104187100A CN 201410408660 A CN201410408660 A CN 201410408660A CN 104187100 A CN104187100 A CN 104187100A
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Abstract
The invention provides an application of N-carbamylglutamic acid (NCG) to promoting sexual development of replacement gilts. The N-carbamylglutamic acid (NCG) can be added into replacement gilt daily ratio and can promote the sexual development; the initial hybridization time is shortened and the weight at the puberty and the weight of a control group have no remarkable reference; the replacement gilts are hybridized when having oestrus for the second time; and the hybridization pregnancy rate, the litter size, living piglets and newborn average weight of the replacement gilts in an added group and the control group have no remarkable reference. Visibly, the NCG can promote sexual maturity in the breeding of the replacement gilts and the breeding efficiency of the replacement gilts can be improved; a swinery structure of a pig farm is optimized, and feed and time cost for breeding the replacement gilts can be saved and the economic benefits are improved; and the popularization and application prospect is good.
Description
Technical field
The present invention relates to animal reproduction breeding field, be specifically related to N-carbamylglutamic acid (NCG) in the application promoting in replacement gilt sexual development.
Background technology
The common replacement gilt in large scale of pig farm field is out of heat, puberty is slow and the breeding difficulty symptom such as not obvious of oestrusing, and causes the mortality of replacement gilt up to more than 30% (Stancic etc., 2011).In addition the year turnover rate of the numerous sow of large scale of pig farm field energy generally remains on 30%～70%, requires the colony of replacement gilt larger.Visible, the cultivation efficiency of replacement gilt has determined Pig Farm group structure, is also to determine that can pig farm obtain one of key factor of maximum economic benefit.
Large scale of pig farm field replacement gilt breeding difficulty is frequently existing mainly to be caused because sexual development is slow.In recent years, the intensity of lean meat percentage and feed conversion rate is selected to cause physical growth in replacement gilt cultivating process to substantially exceed sexual development, in the time exceeding breeding body weight, also do not reach sexal maturity (Foxcroft etc., 2001).Arginine (Arg) is divided into essential amino acid conventionally, pig can be synthesized Arg, but before sexal maturity, Arg synthetic quantity can not meet the needs (only meeting 60%～70%) that pig is grown, therefore replacement gilt Japan and China must have sufficient amount Arg (Shanxi is superfine, 2010; Wu Chen etc., 2011).In actual production, domestic scale pig lacks feed specially used for reserved sows, and general choice for use big porker material or milking sow material replace.Therefore, replacement gilt daily ration arginine shortage is the one of the main reasons that causes sexual development slow.
N-carbamylglutamic acid (N-Carbamylglutamate, NCG) can be used as metabolic activation agent and participate in dihydropyrrol-5-carboxylic acid synzyme (P5CS) and the activation of carbamyl phosphate synthetase I (CPS-I), promote glutamine or proline synthesis citrulling, and then the synthetic (Wu etc. of promotion arginine (Arg), 2010), be also therefore referred to as activator in arginine.NCG can make body arginine maintain higher physiological level, at the material that can be converted into important biomolecule activity after a series of metabolic processes, is mainly nitric oxide (NO) and polyamines (comprising putrescine, spermidine and spermine).These materials are playing an important role aspect regulation and control body Nutrition and Metabolism and immune response, especially like this on multifetation animal.
Summary of the invention
For above-mentioned deficiency, the invention provides N-carbamylglutamic acid (NCG) in the purposes promoting in replacement gilt sexual development.
The present invention studies discovery, adds N-carbamylglutamic acid (NCG) and can promote sexual development in replacement gilt daily ration, shortens first breeding time, and does not affect replacement gilt reproductive performance.Accordingly, the present invention adopts following technical scheme:
N-carbamylglutamic acid promotes the application of replacement gilt sexual development.
Preferably, the use amount of described N-carbamylglutamic acid in daily ration is 0.05～0.1%.
More preferably, the use amount of described N-carbamylglutamic acid in daily ration is 0.05%.
Promote a method for replacement gilt sexual development, it is in replacement gilt daily ration, to add 0.05～0.1% the N-carbamylglutamic acid replacement gilt of feeding.
Preferably, in replacement gilt daily ration, add 0.05% the N-carbamylglutamic acid replacement gilt of feeding.
In the time feeding replacement gilt, should provide for oneself when sow weight is about 60 ㎏ and start to add NCG, until breeding.Add NCG early than 60 ㎏ the sexual development of replacement gilt is not played to better facilitation, also affect its facilitation to sexual development and cross interpolation in evening.Therefore, 60 ㎏ are the starting points of preferably feeding.
The present invention adds N-carbamylglutamic acid (NCG) in replacement gilt daily ration can promote sexual development, shortens first breeding time, and does not affect replacement gilt reproductive performance, can save feed and time cost that replacement gilt is cultivated.Replacement gilt is since 60 ㎏ until 0.05% and 0.1% NCG is added in breeding in daily ration, and replacement gilt puberty shifts to an earlier date respectively 19.8 and 14.8 days (P<0.05), and body weight when puberty and control group are without significant difference; Replacement gilt is bred in the time oestrusing for the second time, and the breeding pregnancy rate of interpolation group and control group replacement gilt, litter size, product young number alive and nascent equal weight average are without significant difference.Visible, NCG uses in replacement gilt is cultivated can promoting sexual maturity, can improve the cultivation efficiency of replacement gilt, optimizes Pig Farm group structure, and then reduces pig farm cost, increases economic efficiency, and has good popularizing application prospect.
Brief description of the drawings
In Fig. 1 daily ration, add the impact of NCG on reproduction in replacement gilt serum (length) hormonal readiness.
Detailed description of the invention
Following examples further illustrate content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, the amendment that the inventive method, step or condition are done or replacement, all belong to scope of the present invention.
If do not specialize, the conventional means that in embodiment, technological means used is well known to those skilled in the art.
Embodiment 1 breeding sow test
Experimental subjects: length × 60 of the large binary replacement gilts of 60 ㎏ left and right
Experimental technique: in November, 2012, length × 80 of large binary replacement gilts of selecting and remain about 60 ㎏ at suburb of Beijing large-scale pig farm, are divided into 4 groups, normally feed, and carry out respectively following processing (table 1):
Table 1 replacement gilt experimental design
In the time that increasing to 80 ㎏ left and right, replacement gilt body weight starts to lure feelings with examination feelings boar, every day each 1 time sooner or later.Replacement gilt is bred in the time oestrusing for the second time, replacement gilt first estrus time, oestruses body weight, breeding pregnancy rate and farrowing situation in table 2 for the first time.
In table 2 daily ration, add the impact that NCG cultivates replacement gilt
*, oestrus for the first time before the 210 ages in days ratio of replacement gilt.Colleague's data lowercase subscript represents to exist significant difference (P<0.05).
As shown in table 2, test group and control group replacement gilt in the time oestrusing for the first time body weight without significant difference, all in 120 about ㎏; But want early first estrus time to add the replacement gilt of 0.05%NCG and 0.1%NCG, 0.05% and 0.1%NCG add replacement gilt time puberty and you can well imagine first 19.8 and 14.8 days (P<0.05) than contrast component; Adding in the replacement gilt of NCG, 0.05% interpolation lower puberty of level,, control group and 0.01%NCG interpolation group replacement gilt time puberty were without significant difference than Zao 5.0 days of 0.1% interpolation level.Test group and control group replacement gilt all do not have significant difference at breeding pregnancy rate, litter size, product young number alive, nascent counterpoise.
Feeding experiment explanation in early stage: 0.05%NCG and 0.1%NCG add can promote replacement gilt sexual development, the age in days that reaches breeding body weight shifts to an earlier date more than 15 days, while oestrusing for the second time, breed its reproductive performance and control group indifference.0.05% or 0.1% NCG can shift to an earlier date replacement gilt just joins of the right agely, saves aquaculture cost.
On this basis, study that 0.05%NCG is different adds the impact on replacement gilt sexual development on nursing opportunity, the results are shown in Table 3.Replacement gilt finishes respectively (60 ages in days, 30 ㎏ left and right) in the child care phase and 60 ㎏ left and right starts to add 0.05%NCG, starts to lure feelings, every day each 1 time sooner or later in the time that body weight increases to 80 ㎏ left and right with examination feelings boar.Replacement gilt is bred in the time oestrusing for the second time, replacement gilt on-test age in days, body weight, and first estrus time, oestrus body weight, breeding pregnancy rate and farrowing situation in table 3 for the first time.
The impact that the different interpolation time of table 3 0.05%NCG cultivates replacement gilt
*, oestrus for the first time before the 210 ages in days ratio of replacement gilt.Colleague's data lowercase subscript represents to exist significant difference (P<0.05).
From table 3,0.05%NCG starts to add at 30 ㎏ and 60 ㎏ the cultivation of replacement gilt has been produced to impact in various degree.Compared with starting to add 0.05%NCG with 60 ㎏, replacement gilt adds 0.05%NCG since 30 ㎏, and it is just joined the of the right age time and has delayed 12 days, just timing body weight increases by 10 ㎏ left and right, and the rate of oestrusing and breeding pregnancy rate have reduced respectively 10% and 5.3%, and reproductive performance is without significant difference.In addition, 60 ㎏ start to add 0.05%NCG can reduce the use amount of NCG, cultivates cost also relatively low.Consider, replacement gilt starts to add 0.05%NCG at 60 ㎏ can effectively promote sexual development, improves and cultivates efficiency.
Embodiment 2 NCG are in the relative physiologic index detection promoting in replacement gilt sexual development nursing
Add test group and the control group of 0.05%NCG according to embodiment 1, respectively at replacement gilt 105d, 120d, 135d, 150d, 165d, 180d, 195d and 210d blood sample collection, analyzed the level of the main reproduction/growth hormone such as gonadotropin-releasing hormone (GRH) (GnRH), follicle-stimulating hormone (FSH) (FSH), metakentrin (LH), estrogen (E), progesterone (PROG), growth hormone (GH) in blood serum sample, result is as Fig. 1.
As shown in Figure 1, in replacement gilt daily ration, add NCG GnRH, PROG in serum and LH levels of reproductive hormones are not made significant difference, but larger on the impact of GH, E in blood and FSH level.Wherein, the GH concentration of higher level may be test group similar main cause of body weight while oestrusing for the first time with control group.Test group E level is also high compared with control group, has reflected that the follicular development of test group replacement gilt will be faster than control group; Test group FSH level is also higher than control group, strong support test group replacement gilt can to breed and breed achievement unaffected oestrusing for the first time.Infer thus, in blood, high-caliber GH, E and FSH are the physiological reasons that NCG promotes replacement gilt sexual development.
Claims (6)
1.N-carbamylglutamic acid promotes the application of replacement gilt sexual development.
2. application according to claim 1, is characterized in that, the use amount of described N-carbamylglutamic acid in daily ration is 0.05～0.1%.
3. application according to claim 2, is characterized in that, the use amount of described N-carbamylglutamic acid in daily ration is 0.05%.
4. promote a method for replacement gilt sexual development, it is in replacement gilt daily ration, to add 0.05～0.1% the N-carbamylglutamic acid replacement gilt of feeding.
5. method according to claim 4, is characterized in that adding 0.05% the N-carbamylglutamic acid replacement gilt of feeding in replacement gilt daily ration.
6. according to the method described in claim 4 or 5, it is characterized in that, grow to 60 ㎏ from replacement gilt and start to feed until breed.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104824377A (en) * | 2015-05-27 | 2015-08-12 | 北京市农林科学院 | Heat-stress-resistant breeding promotion composite additive for sows |
| CN104920911A (en) * | 2015-07-10 | 2015-09-23 | 四川傲农生物科技有限公司 | Feed additive for improving pregnant sow reproductive performance and preparing method thereof |
| CN105766794A (en) * | 2016-03-21 | 2016-07-20 | 青岛源之林农业科技开发有限公司 | Breeding method for improving reproductive performance of Landrace sows |
| CN107279484A (en) * | 2017-07-05 | 2017-10-24 | 北京四方红饲料科技有限公司 | It is a kind of to be used for the compound premix and grain of replacement gilt or nonpregnant sows |
| CN108902036A (en) * | 2018-07-25 | 2018-11-30 | 西藏自治区农牧科学院畜牧兽医研究所 | A kind of cultural method improving hiding pig farrowing rate |
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| CN102318763A (en) * | 2011-08-26 | 2012-01-18 | 北京大北农科技集团股份有限公司 | Additive composite premix and batch for prepubertal gilt |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104824377A (en) * | 2015-05-27 | 2015-08-12 | 北京市农林科学院 | Heat-stress-resistant breeding promotion composite additive for sows |
| CN104824377B (en) * | 2015-05-27 | 2017-12-26 | 北京市农林科学院 | One broad sow anti-heat stress promotees breeding compound additive |
| CN104920911A (en) * | 2015-07-10 | 2015-09-23 | 四川傲农生物科技有限公司 | Feed additive for improving pregnant sow reproductive performance and preparing method thereof |
| CN104920911B (en) * | 2015-07-10 | 2018-01-26 | 四川傲农生物科技有限公司 | A kind of feed addictive for improving reproduction performance of gestation sow and preparation method thereof |
| CN105766794A (en) * | 2016-03-21 | 2016-07-20 | 青岛源之林农业科技开发有限公司 | Breeding method for improving reproductive performance of Landrace sows |
| CN107279484A (en) * | 2017-07-05 | 2017-10-24 | 北京四方红饲料科技有限公司 | It is a kind of to be used for the compound premix and grain of replacement gilt or nonpregnant sows |
| CN108902036A (en) * | 2018-07-25 | 2018-11-30 | 西藏自治区农牧科学院畜牧兽医研究所 | A kind of cultural method improving hiding pig farrowing rate |
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