CN104171103B - Prevent and treat the strongly fragrant health protection tea of hypoglycemic solution of diabetes complicated depression - Google Patents
Prevent and treat the strongly fragrant health protection tea of hypoglycemic solution of diabetes complicated depression Download PDFInfo
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- CN104171103B CN104171103B CN201410322646.1A CN201410322646A CN104171103B CN 104171103 B CN104171103 B CN 104171103B CN 201410322646 A CN201410322646 A CN 201410322646A CN 104171103 B CN104171103 B CN 104171103B
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Abstract
The present invention relates to the strongly fragrant health protection tea of hypoglycemic solution preventing and treating diabetes complicated depression, what effectively can solve diabetes complicated depression prevents and treats problem, its technical scheme solved is, by tealeaves, witloof, folium cortex eucommiae, lotus seeds, Flos Albiziae, radix rehmanniae recen and sealwort be by weight: 1 ~ 2: 1 ~ 5: 1 ~ 4: 1 ~ 3: 1 ~ 4: 1 ~ 3: 1 ~ 4 make, abundant raw material of the present invention, cost is low, easily produces and drinks, effective, what be effective to diabetes complicated depression prevents and treats problem.
Description
Technical field
The present invention relates to beverage, particularly a kind of strongly fragrant health protection tea of hypoglycemic solution preventing and treating diabetes complicated depression.
Background technology
Depression is one of diabetes common complication, and the probability that diabetic suffers from depression is 3 times of normal person.Foreign literature is reported, diabetic has 60% ~ 75% with depressive emotion, and wherein 10% ~ 35% is severe depression.The harm of depression to people is serious.With regard to diabetes, heavy stress, unhealthy emotion not only can make blood sugar raise, and reduce the compliance for the treatment of, also can accelerate the generation of the complication such as the heart, kidney, unfavorable to the prognosis of the state of an illness.Otherwise glycemic control is bad, aggravation, can cause patient's mental suffering, pessimism etc. again, increase the weight of their depressive symptom.In addition, major depressive disorder also can cause pessimism and despair, even occurs autotomy and suicide.Traditional Chinese medicine and pharmacy is a large treasure-house, and treating various disease has unique distinction, and diabetes complicated depression rate is high, and social danger is large, but lacks the open report carrying out the strongly fragrant health-care tea beverage of hypoglycemic solution prevented and treated for diabetes complicated depression so far.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, the object of the present invention is to provide a kind of strongly fragrant health protection tea of hypoglycemic solution preventing and treating diabetes complicated depression, and what effectively can solve diabetes complicated depression prevents and treats problem.
The technical scheme that the present invention solves is, by tealeaves, witloof, folium cortex eucommiae, lotus seeds, Flos Albiziae, radix rehmanniae recen and sealwort be by weight: 1 ~ 2:1 ~ 5:1 ~ 4:1 ~ 3:1 ~ 4:1 ~ 3:1 ~ 4 mix, be ground into granularity≤1.5mm powdery, packing, when drinking, add boiling water and soak; Described tealeaves is the one of green tea, black tea or jasmine tea;
Or according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1 ~ 2:1 ~ 5:1 ~ 4:1 ~ 3:1 ~ 4:1 ~ 3:1 ~ 4 prepare, granularity≤1.5mm makes raw material, then the water of 2 ~ 3 times of raw material weight is added, be heated to 80 ~ 100 DEG C and boil 10-60min, filter, obtain filtrate, filter residue adds the poach 10-60min of 1.5 ~ 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, encapsulation, described tealeaves is the one of green tea, black tea or jasmine tea.
The health protection tea of the diabetes complicated depression of control of any amount is can be made into by above-mentioned formula and method.
Abundant raw material of the present invention, cost is low, easily produces and drinks, effective, and what be effective to diabetes complicated depression prevents and treats problem.
Detailed description of the invention
Embodiment 1
The present invention in the specific implementation, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1:1:1:1:1:1:1 prepares, and granularity≤1.5mm, is packaged into bag.
Embodiment 2
The present invention in the specific implementation, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 2:5:4:3:4:3:4 prepares, and granularity≤1.5mm, is packaged into bag.
Embodiment 3
The present invention in the specific implementation, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1.5:3:2.5:2:2.5:2:2.5 prepares, and granularity≤1.5mm, is packaged into bag.
Embodiment 4
According to black tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1.5:3:2.5:2:2.5:2:2.5 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described black tea is keemun.
Embodiment 5
According to jasmine tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 2:5:4:3:4:3:4 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described jasmine tea is Jasmine.
Embodiment 6
According to green tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1:1:1:1:1:1:1 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described green tea is high-quality green tea.
Applicant it is to be noted, above-described embodiment is interpreted as only being not used in for illustration of the present invention limiting the scope of the invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.
In said medicine, wherein witloof is the aerial part of feverfew witloof CichoriumintybusL., the micro-hardship of the property of medicine, salty, cool, effect of tool clearing liver cholagogic, stomach strengthening and digestion promoting, inducing diuresis to reduce edema, for jaundice with damp-heat pathogen, stomachache food less, oedema oliguria; Folium cortex eucommiae is the dry leaf of Eucommiaceae plant bark of eucommia EucommiaulmoidesOliv., and the property of medicine is micro-pungent, warm, returns liver, kidney channel, has effect of filling liver kidney, strengthening the bones and muscles, for kidney deficiency and liver, have a dizzy spell, soreness of waist and knee joint, muscles and bones impotence be soft; Lotus seeds are the dry mature seed of nymphaeaceae plant lotus NelumbonuciferaGaertn., the property of medicine is sweet, puckery, flat, returns spleen, kidney, the heart channel of Hang-Shaoyin, there is effect of tonifying spleen antidiarrheal, only band, the puckery essence of kidney-nourishing, mental-tranquilization, under splenasthenic diarrhea, band, pass out semen, palpitation and insomnia; Flos Albiziae is the dry inflorescence of legume silk tree AlbiziajulibrissinDurazz., and the property of medicine is sweet, and flat, the thoughts of returning home, Liver Channel, have effect of resolving stagnation for tranquilization, for confused and worried, melancholy insomnia; Radix rehmanniae recen is the dried root of scrophulariaceae rehmannia glutinosa plant RehmanniaglutinosaLibosch., the property of medicine is sweet, cold, the thoughts of returning home, liver, kidney channel, there is effect of clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, enter ying blood for heat, constipation is hindered in febrile virulent maculae, hematemesis and epistaxis, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin, fever due to yin deficiency, hectic fever due to yin labor heat, interior heat quenches one's thirst; Sealwort is the dry rhizome of liliaceous plant sealwort PolygonatumsibiricumRed., the property of medicine is sweet, flat, return spleen, lung, kidney channel, have effect of boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing, for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry is eaten less, deficiency syndrome of the lung cough caused by dryness, labor cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, interior heat are quenched one's thirst.Above Six-element Chinese medicine share, play altogether tonify the liver and kidney, the function of nourishing Yin and clearing heat, invigorating spleen and nourishing heart, resolving stagnation for tranquilization.
The present invention is first with the strongly fragrant health protection tea of hypoglycemic solution that witloof, folium cortex eucommiae, lotus seeds, Flos Albiziae, radix rehmanniae recen, sealwort are made for primary raw material, played the tonifying the liver and kidney of folium cortex eucommiae, sealwort and radix rehmanniae recen, the invigorating spleen and nourishing heart of lotus seeds, the resolving stagnation for tranquilization of lotus seeds and Flos Albiziae, the eliminating dampness and heat of witloof, the nourishing Yin and clearing heat of radix rehmanniae recen simultaneously, can be common to control clinical in common polytype diabetes complicated depression such as deficiency of the liver and kidney, type of YIN-deficiency and interior-heat, type of deficiency of both the heart and spleen, liver gallbladder damp-heat type.In addition, witloof and the radix rehmanniae recen property of medicine is partially cold and cool and folium cortex eucommiae is partially warm, lotus seeds, Flos Albiziae and sealwort are levelling, and the formula of whole tea is bordering on levelling, avoid and drink the partially cold or drawback that injures one's stomach of temperature partially for a long time; Selected material medicine majority has sugariness simultaneously, lay a good foundation for this tea has better mouthfeel, be effective to the control of diabetes complicated depression, and through experiment, it prevents and treats the remarkably productive of diabetes complicated depression, use product of the present invention through some diabetes complicated patients with depression, serve significantly health care and auxiliary therapeutic action; Simultaneously by the zoopery of products application of the present invention in anti-diabetic complicated with depression, result shows product anti-diabetic complicated with depression Be very effective of the present invention.Products taste of the present invention is comfortable simultaneously.The great advantage of product of the present invention is without any side effects, can be used as beverage and drinks for a long time.
Regarding assay data is as follows:
1.1 experiment material
1.1.1 animal subject
Kunming (KM) mouse,
, body weight 20 ~ 22g, is provided by Henan Province's Experimental Animal Center [SCXK (Henan) 2010-0002].
1.1.2 test article is health protection tea of the present invention
1.2 experimental technique
1.2.1 animal processing method
First bibliography method copies Streptozotocin (STZ) diabetes mice model, then film forming diabetic mice bibliography method being copied chronic unpredictable gentleness stress (CUMS) depression model, i.e. diabetes complicated depression model; CUMS animal on the same day gives tested health protection tea, continues 3 weeks; Before administration, administration 1,3 weeks respectively group test blood sugar, syrup consumption and Open-field test are carried out in each group of administration 1,3 weeks, and integrated survey test health protection tea is to the preventive and therapeutic effect of diabetes complicated depression.
Other necessary information: the aseptic sodium citrate buffer of (1) STZ 0.1mol/L (pH4.2) prepares, and mouse (can't help water) after fasting 16h, and disposable celiac injection (ip) STZ (150mg/kg) makes diabetes model; (2) mouse (through ipSTZ modeling) is after the free diet of 72h, blood glucose value (blood sugar > 12mmol/L is that diabetes model is successful) is measured in tail venous blood sampling blood glucose meter, the mouse that screening blood glucose value is greater than 12mmol/L gives chronic unpredictable gentleness again stress (CUMS), and every day gives one at random stress; (3) CUMS mainly comprises: of short duration same cage is raised (every cage 9 or 10) 3h; Make smell (bedding and padding of the mouse) 3h of mouse fear; Noise (radio of non-frequency modulation) 3h; Rearging cage tilts (about 30 degree) 8h or spend the night; Moist bedding and padding (50mL water) 8h or spend the night; Without bedding and padding new rearging cage 8h or spend the night; Illumination is spent the night; (4) positive drug (DMBG-FH) adopts Metformin hydrochloride (to be called for short DMBG, dosage 100mg/kg) and Fluoxetine hydrochloride (abbreviation FH, dosage 10mg/kg) drug combination (ig administration), tested health protection tea dosage is 5g/kg.(5) model group and a normal group ig give equivalent solvent (0.5%CMC-Na), and wherein normal group does not give modeling and model group gives modeling, and two groups all do not give any tested health protection tea.(6) positive drug and each tested health protection tea are all dissolved with 0.5%CMC-Na or are suspended to required administration concentration.
1.2.2 syrup consumption is tested
Mouse 24h before experiment, by the sugary drinking-water of training adaptation, tests after water 12h is prohibited in fasting.During test, the single cage of all mouse is raised, carry out in quiet room, every cage is put two water bottles and (is inside respectively charged into clear water and 1% sucrose water, volume is 100mL, two bottles of positions are put at random), in measuring 2 hours, mouse 1% sucrose water takes in volume and clear water absorption volume, by the syrup consumption of formulae discovery every animal.Syrup consumption computing formula is as follows:
Syrup consumption=[volume/(syrup is taken in volume+clear water and taken in volume) × 100% taken in by syrup].
1.2.3 Open-field test
Bibliography method, the wooden case that spacious case apparatus is each 50cm of length and width, high 25cm, bottom surface is divided into 25 equilateral grids, inner face fills with pitch-dark.Mouse is put into center grid, observe mouse to creep in 3min and pass through lattice number (all entering a grid with the four limbs of mouse is lattice) and number of times of standing (leaves ground with two forelimbs of mouse, body erect is once), thoroughly carry out the observation of lower 1 mouse after clean spacious case again.When experiment starts, mouse is put into center one lattice, add up immediately and the lattice number that passes through of the mouse level in 3min that records as horizontal score, number of times of standing as vertical score.
1.3 experimental result
1.3.1 health protection tea is on the impact of diabetes complicated depression mouse fasting blood-glucose
As shown in table 1, compare with normal group, model group mouse fasting blood-glucose significantly raises, and shows that STZ makes diabetes model success.Compare with model group, after giving tested medicine 1-3 week, positive drug DMBG-FH and health protection tea (A-F) all can make hyperglycaemia mouse blood sugar significantly reduce, prompting DMBG-FH and health protection tea (A-F) all have hypoglycemic activity in administration 1-3 week, wherein within 3 weeks, act as good with administration.This experimental result shows that the strongly fragrant health protection tea of Chinese medicine hypoglycemic solution has the effect reducing diabetes complicated depression mouse blood sugar, and also suitable with positive drug DMBG-FH effect.
Table 1 health protection tea on the impact of diabetes complicated depression mouse fasting blood-glucose (n=10,
)
Compare with normal group,
1)p<0.05,
2)p<0.01; Compare with model group,
3)p<0.05,
4)p<0.01
1.3.2 health protection tea is to diabetes complicated depression mouse syrup consumption and prologue behavioral implications
As shown in table 2 and table 3, after hyperglycaemia mouse adopts CUMS process mouse 1-3 week, compare with normal group, model group mouse creeps and passes through lattice number, stand number of times and syrup consumption all significantly reduces (P<0.05), because creeping of mouse is passed through lattice number and can be reflected its activity, number of times of standing can reflect that it is to the good singularity of surrounding environment and exploration, syrup consumption can reflect that it is to the reactivity of awarding, therefore the result hyperglycaemia mouse of pointing out this research institute to adopt is after CUMS stimulates, can diabetic mice simulate that depressive patients shows with it cold and detached, the Clinical symptoms such as motion minimizing and anhedonia, show that this research CUMS modeling program can continue, effectively cause the shortage of diabetic mice pleasant sensation, show the success of diabetes complicated depression model, compare with model group, after giving tested medicine 1-3 week, health protection tea (A-F) and positive drug DMBG-FH all can significantly improve that mouse passes through lattice number, stand number of times and syrup consumption, prompting health protection tea has the effect preventing and treating diabetes complicated depression, and also suitable with positive drug DMBG-FH effect.
Table 2 health protection tea on the impact of diabetes complicated depression mouse syrup consumption (n=10,
)
Compare with normal group,
1)p<0.05,
2)p<0.01; Compare with model group,
3)p<0.05,
4)p<0.01
Table 3 health protection tea on the impact of diabetes complicated depression mouse prologue behavior (n=10,
)
Compare with normal group,
1)p<0.05,
2)p<0.01; Compare with model group,
3)p<0.05,
4)p<0.01
Above-mentioned test can clearly show, the invention discloses the health protection tea preventing and treating diabetes complicated depression, can be used for preparing anti-diabetic patients complicated with depression health protection tea safely and efficiently and prevent and treat the application of diabetes complicated depression health protection tea as preparation, creative contribution is made in the development being applied to health protection tea for traditional Chinese medicine.
Claims (8)
1. the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control, it is characterized in that, by tealeaves, witloof, folium cortex eucommiae, lotus seeds, Flos Albiziae, radix rehmanniae recen and sealwort be by weight: 1 ~ 2:1 ~ 5:1 ~ 4:1 ~ 3:1 ~ 4:1 ~ 3:1 ~ 4 mix, be ground into granularity≤1.5mm powdery, packing, when drinking, add boiling water and soak; Described tealeaves is the one of green tea, black tea or jasmine tea.
2. the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 1, it is characterized in that, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1:1:1:1:1:1:1 prepares, granularity≤1.5mm, is packaged into bag.
3. the preparation method of the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 1, it is characterized in that, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 2:5:4:3:4:3:4 prepares, granularity≤1.5mm, is packaged into bag.
4. the preparation method of the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 1, it is characterized in that, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1.5:3:2.5:2:2.5:2:2.5 prepares, granularity≤1.5mm, is packaged into bag.
5. the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control, it is characterized in that, according to tealeaves: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1 ~ 2:1 ~ 5:1 ~ 4:1 ~ 3:1 ~ 4:1 ~ 3:1 ~ 4 prepare, granularity≤1.5mm makes raw material, then the water of 2 ~ 3 times of raw material weight is added, be heated to 80 ~ 100 DEG C and boil 10-60min, filter, obtain filtrate, filter residue adds the poach 10-60min of 1.5 ~ 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, encapsulation, described tealeaves is the one of green tea, black tea or jasmine tea.
6. the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 5, it is characterized in that, according to black tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1.5:3:2.5:2:2.5:2:2.5 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described black tea is keemun.
7. the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 5, it is characterized in that, according to jasmine tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 2:5:4:3:4:3:4 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described jasmine tea is Jasmine.
8. the preparation method of the strongly fragrant health protection tea of hypoglycemic solution of the diabetes complicated depression of control according to claim 5, it is characterized in that, according to green tea: witloof: folium cortex eucommiae: lotus seeds: Flos Albiziae: radix rehmanniae recen: the weight ratio of sealwort is pulverize after 1:1:1:1:1:1:1 prepares, granularity≤1.5mm makes raw material, then the water of 3 times of raw material weight is added, be heated to 100 DEG C and boil 20min, filter, obtain filtrate, filter residue adds the poach 15min of 2 times of raw material weight again, filter, merge twice filtrate, then relative density 1.5 at being concentrated into 60 DEG C, be prepared into liquid extract, add water in a conventional way again, acid, spices and sweetener, make the health protection tea of different taste, be packaged into bottled or pop can, , described green tea is high-quality green tea.
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| CN107668260A (en) * | 2017-11-02 | 2018-02-09 | 包梅花 | A kind of anaesthetic hypoglycemic health-care tea |
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| 中医中药治疗糖尿病;梁晓春等;《中国农村医学 》;19971231(第9期);9-23 * |
| 中医治疗糖尿病的用药思路与方法;周超凡;《首都医药》;20041231(第21期);43-45 * |
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