CN104162074A - Traditional Chinese medicinal composition for treating respiratory infectious diseases of animals, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating respiratory infectious diseases of animals, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating respiratory infectious diseases of animals, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines for animals. The traditional Chinese medicinal composition comprises, by weight, 600-1000 parts of isatis root, 400-600 parts of Rhizoma Anemarrhenae, 300-600 parts of Radix Stemonae, 10-40 parts of borneol, 3-10 parts of Venenum Bufonis, 100-200 parts of borax, 10-50 parts of Natural Indigo, 20-50 parts of realgar, 200-500 parts of Radix Platycodonis, 100-300 parts of Radix Scutellariae and 100-300 parts of catechu. The composition prepared through blending the above 11 Chinese herbal medicines according to a monarch, minister, assistant and guide principle has the efficacies of phlegm dispelling, cough relieving and panting calming, is mainly used for treating the infectious laryngotracheitis, the infectious rhinitis, the infectious bronchitis and other diseases of chicken, has reliable curative effects, and rapidly acts. The composition adopting pure natural Chinese herbal medicines has the advantages of easily available raw medicines, low price, safety, and no residual. The traditional Chinese medicinal composition can be processed to prepare powder, and the preparation method has the advantages of simplicity, easy operation and suitableness for large scale production application.
Description
Technical field
The present invention is specifically related to a kind of veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease, and the preparation method of this Chinese medicine composition, belongs to Chinese medicine technical field for animals.
Background technology
Chicken respiratory spreading venereal diseases accounts for 30% left and right of common diseases of chickens, and not etc., and growth retardation after morbidity, or degradation under laying rate, do not brought very serious economic loss to current poultry husbandry band in fatality rate 1～70%.
Wherein, infectious laryngotracheitis of chicken is a kind of Acute respiratory infectious disease being caused by herpesvirus, and its feature shows as cough, dyspnea, trachea sound of vomiting sound, spitting of blood, and pathological change is larynx, tracheal mucosa hyperemia, edema, hemorrhage, downright bad.Infectious laryngotracheitis of chicken is multiple is born in young chicken and laying hen, and sickness rate can reach 90～100%, and mortality rate is about 10～20%, and sometimes up to 70%, as without secondary infection, the course of disease is generally at 7～14 days, and the chicken of recovering can be with poison, toxin expelling for a long time, becomes the source of infection.
Infectious coryza of chicken is the acute respiratory systemic disease by chicken that haemophilus paragallinarum causes, cardinal symptom is nasal cavity and Dou Fayan, rhinorrhea, facial swelling and sneeze.This disease betides the chicken at various ages, and aged chicken infects comparatively serious.Though sickness rate height but mortality rate is lower, especially popular morning, mid-term chicken group seldom have dead chicken to occur, chicken, group recovers the stage, death toll increases, but loses peak mortality.Pathological anatomical change also more complicated is various, and the dead chicken having has a kind of main pathological change of disease, and some chickens have the pathological change feature of 2～3 kinds of diseases concurrently.
Infectious bronchitis of chicken is the acute height contact of the one respiratory infectious disease of the chicken that caused by infectious bronchitis virus, its face examine be characterized as dyspnea, send rale, cough, mouth breathing, sneeze.If cause of disease is not nephropathy modification strain or intercurrent disease does not occur, mortality rate is generally very low.Laying hen infects and is usually expressed as egg production reduction, and the quality of egg declines.
There are long history and the rich experiences of Chinese medicine application in China, for this reason, a kind of determined curative effect of Research and development and production, effect rapidly, toxic and side effects little for preventing and treating the Chinese medicine of chicken respiratory infectious disease, be the outer veterinary drug worker's of Now Domestic a urgency task.
Summary of the invention
The object of this invention is to provide a kind of veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease.
Meanwhile, the present invention also provides a kind of preparation method of the veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease.
In order to realize above object, the technical solution adopted in the present invention is:
Be used for the treatment of a veterinary Chinese medicinal composition for respiratory infectious disease, formed by the crude drug of following weight portion: 600～1000 parts of Radix Isatidis, 400～600 parts of the Rhizoma Anemarrhenaes, 300～600 parts of the Radixs Stemonae, 10～40 parts of Borneolum Syntheticums, 3～10 parts of Venenum Bufoniss, 100～200 parts of Boraxs, 10～50 parts of Indigo Naturaliss, 20～50 parts of Realgars, 200～500 parts of Radix Platycodoniss, 100～300 parts of Radix Scutellariaes, 100～300 parts, catechu.
Preferably, be used for the treatment of a veterinary Chinese medicinal composition for respiratory infectious disease, formed by the crude drug of following weight portion: 700 parts of Radix Isatidis, 500 parts of the Rhizoma Anemarrhenaes, 400 parts of the Radixs Stemonae, 27 parts of Borneolum Syntheticums, 5 parts of Venenum Bufoniss, 100 parts of Boraxs, 33 parts of Indigo Naturaliss, 35 parts of Realgars, 350 parts of Radix Platycodoniss, 200 parts of Radix Scutellariaes, 150 parts, catechu.
Described Borax loses water of crystallization and obtains anhydrous compound after calcination processing.
Each crude drug effect is summarized as follows:
Radix Isatidis: be the root of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.; Contain indigo, indirubin and several amino acids, as arginine, glutamic acid etc., also contain the various active compositions such as sinigrin, indigo glycosides, couroupitine A; Nature and flavor hardship, cold, GUIXIN, lung.Liver, stomach warp; Energy heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving; Cure mainly anemopyretic cold, influenza, epidemic encephalitis, encephalitis b, major part pestilence, scarlet fever, waits separately disease; Modern pharmacology proves that Radix Isatidis has antibacterium, antiviral, antiendotoxin, the effect such as anticancer, has regulating action to immune system simultaneously.
The Rhizoma Anemarrhenae: be the rhizome of the Liliaceae Anemarrhena plant Rhizoma Anemarrhenae; Contain the various active compositions such as steroidal saponin, flavonoid, polysaccharide, choline; Nature and flavor hardship, cold lung, stomach, the kidney channel of returning; Energy clearing away heat-fire, preventing phlegm from forming and stopping coughing, nourshing Yin and drynsessmoistening prescription; Cure mainly calentura high fever excessive thirst, cough due to lung-heat, laryngopharynx swelling and pain, osteopyrexia and fever, restlessness of asrhenia type and insomnia, quench one's thirst stranguria with turbid discharge, constipation etc.; Modern pharmacology proves that the Rhizoma Anemarrhenae has the effects such as resisting pathogenic microbes, antiinflammatory, antitumor.
The Radix Stemonae: be the root of Stemonaceae Stemona plant Radix Stemonae, Radix stemonae japonicae and radix stemonae tuberosae; Contain alkaloids as (-)-Stemoninine, protostermonine, tuberostemonine etc., fatty acid is as various active compositions such as formic acid, acetic acid, malic acid, citric acid; Nature and flavor hardship, micro-sweet, tepor, returns lung meridian; Energy nourishing the lung to arrest cough, parasite killing delousing; Cure mainly that new chronic cough is coughed, pulmonary tuberculosis, pertussis etc.; Modern pharmacology proves that the Radix Stemonae has resisting pathogenic microbes, parasiticide, kills insecticide, antitussive, the effect such as eliminate the phlegm, relieving asthma.
Borneolum Syntheticum (MEIHUA BINGPIAN): the natural crystallinity compound of separating out in the resin for Dipterocarpaceae Dipterocarpus plant borneo camphor tree, composition is dextro Borneolum Syntheticum; Nature and flavor are pungent, bitter, cool, enter the heart, lung meridian; Can have one's ideas straightened out refreshment, heat radiation pain, improving eyesight removing nebula; Cure mainly apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, conjunctivitis, sore throat, aphtha, carbuncle, hemorrhoid etc.; Modern pharmacology proves that Borneolum Syntheticum has the effects such as antiinflammatory, antibacterial, antifertility.
Venenum Bufonis: the white juice that belongs to the then glandular secretion of the sibling species such as Hua Da Venenum Bufonis or black socket of the eye Venenum Bufonis in animal for Venenum Bufonis section Venenum Bufonis processes; Contain Venenum Bufonis steroid dienes as Toadpoison Medicine, cinobufacin far away, Japanese bufotalien etc., indole bases is as bufotenine, Venenum Bufonis quaternary ammonium etc., sterols, as cholesterol, ergosterol etc., also contains the various active compositions such as polysaccharide, organic acid, aminoacid, peptide class, epinephrine; Nature and flavor are pungent, temperature, GUIXIN warp; Energy reducing swelling and alleviating pain, removing toxic substances are warded off dirty; Cure mainly swollen rotten, the acute filthy disease stomachache of carbuncle furuncle, laryngopharynx swelling and pain, wind carious pain, gingiva etc.; Modern pharmacology proves that Venenum Bufonis has the effects such as shock, antitumor, local anesthesia, and cardiovascular, immunologic function are had to facilitation.
Borax: be borate family Borax family mineral Borax; Mainly contain sodium tetraborate, also contain the impurity such as a small amount of lead, copper, calcium, aluminum, ferrum, magnesium, silicon; Nature and flavor are sweet, salty, cool, attach to the lung and stomach meridians; Can heat clearing away expectorant, detoxify anticorrosion; Cure mainly that phlegm-heat cough, sore throat, thrush, the cancer of the esophagus gather, all a fishbone or other bone caught in the throat larynxs, conjunctival congestion cataracta etc.; Modern pharmacology proves that Borax has the effects such as anticorrosion, convulsion.
Indigo Naturalis: the dried powder or the agglomerate that make through processing for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf; The Indigo Naturalis that Acanthaceous indigo makes contains indirubin, indigo, bioxindol, the Indigo Naturalis that polygonum tinctorium ait. makes contains indirubin, indigo, N-phenyl-2-naphthylamine, cupreol etc., the Indigo Naturalis that Folium et Caulis Indigoferae Tinctoriae makes contains indirubin, and the Indigo Naturalis that Isatis indigotica Fort. makes contains indirubin, indigo, color ammonia ketone, qingdainone etc.; Indigo Naturalis nature and flavor are salty, cold, return liver, lung, stomach warp; Energy heat clearing away, removing heat from blood, removing toxic substances; Cure mainly warm malicious macule, haematemesis, epistaxis, spitting of blood, pediatric epilepsy scared, liver-fire invading the lung cough, laryngopharynx swelling and pain, erysipelas, mumps, skin ulcer swollen etc.; Modern pharmacology proves that Indigo Naturalis has antitumor, anti-inflammatory and antalgic, antiulcer, the effect such as antibacterial.
Realgar: be simple sulfide-based Realgar family mineral Realgar; Mainly contain realgar, and contain the impurity such as silicon, lead, ferrum, calcium, magnesium; Nature and flavor are pungent, bitter, and temperature is returned liver, stomach warp; Can removing toxic substances, parasite killing, dampness, expectorant dispels the wind; Cure mainly carbuncle furuncle, scabies, erysipelas, eczema, hemorrhoid, snake bite and insect sting, acute throat trouble sore throat, epilepsy, malaria, gather polyp, cough with asthma etc. in mass in the abdomen, nose; Modern pharmacology proves that Realgar has the effects such as antitumor, and can Promote immunity Function.
Radix Platycodonis: be the root of campanulaceae Platycodon grandiflouorum Platycodon grandiflouorum; Contain saponin as platycodin A, C, D, D
2, D
3deng, sapogenin as platycodigenin, Polygalacic acid etc., prosapogenin, sterols is as various active compositions such as hitodesterols; Nature and flavor hardship, pungent, flat, attaches to the lung and stomach meridians; Energy lung qi dispersing eliminates the phlegm, sore-throat relieving evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache etc.; Modern pharmacology prove Radix Platycodonis have eliminate the phlegm, the effect such as antitussive, antiinflammatory, antiulcer, blood sugar lowering, cardiovascular system, central nervous system are had to regulating action.
Radix Scutellariae: be the root of Labiatae Scutellaria plant Radix Scutellariae; Contain flavone compound as baicalin, neobaicalein, baicalin, wogonoside etc., also contain the various active compositions such as cupreol, campesterol and stigmasterol; Nature and flavor hardship, cold, returns lung, the heart, liver, gallbladder, large intestine channel; Energy clearing away heat-fire, dampness removing toxic substances, hemostasis, antiabortive; Cure mainly lung-heat cough with asthma, calentura unconsciousness due to high fever, liver-fire headache, conjunctival congestion and swelling pain, jaundice due to damp-heat, dysentery, pyretic stranguria, tell nosebleed, excessive fetal movement due to heat in pregnancy, carbuncle furuncle etc.; Modern pharmacology prove Radix Scutellariae have antimicrobial, antiplatelet aggregation and anticoagulant, antioxidation, anticancer, reduce blood pressure and the effect such as diuresis, blood fat reducing.
Catechu (Catechu): be pulse family sallee catechu heartwood or the fried powdered extract forming of peeling branch; Heartwood contains catechutannic acid 20～50%, and flavonoid is as various active compositions such as left-handed and Racemic catethins, left-handed and racemization epicatechin, fisetins; Nature and flavor hardship, puckery, cool, GUIXIN, lung, spleen channel; Can astringent therapy sore, stop blooding, reduce phlegm; Treatment of ulcer is burst for a long time and is not held back, eczema flowing water, ulcerative gingivitis, aphtha, nasal sinusitis flowing water, spitting of blood, haematemesis, hematuria, have blood in stool, metrorrhagia, traumatic hemorrhage, hemorrhoid carbuncle, phlegm-heat cough etc.; Modern pharmacology prove catechu have protect the liver, the effect such as function of gallbladder promoting, resisting pathogenic microbes, blood sugar lowering, also to immunologic function, blood and learn vascular system and there is regulating action.
A kind of veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease can adopt conventional method to be prepared into the common veterinary medicine dosage forms such as granule, powder, solution.The present invention only provides a kind of preparation method of powder, comprises the steps: accurately to get each taste crude drug according to formula, mixes, sieves after pulverizing.
Described sieves for crossing 60 mesh sieves, then with 50g/ bag subpackage.
Usage and consumption: oral dosage: the every 1kg body weight of chicken 10～15mg, once a day, is used in conjunction 1～3 day; Mixed feeding amount: every 100kg feedstuff 1000g, is used in conjunction 1～3 day.
Beneficial effect of the present invention:
The present invention adopts Radix Isatidis, the Rhizoma Anemarrhenae, the Radix Stemonae, Borneolum Syntheticum, Venenum Bufonis, Borax, Indigo Naturalis, Realgar, Radix Platycodonis, Radix Scutellariae, catechu totally 11 taste pure natural Chinese herbal medicine, and according to monarch principle composition of prescription, in side, Radix Isatidis, Indigo Naturalis, Radix Scutellariae heat-clearing and toxic substances removing are principal agent.Realgar, Borneolum Syntheticum, Borax, Venenum Bufonis are strengthened removing toxic substances and are helped principal agent heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, and changing rotten pain relieving is minister.Assistant is with Radix Platycodonis, the Radix Stemonae, catechu, Rhizoma Anemarrhenae removing heat-phlegm, nourishing the lung to arrest cough, depressed lung-energy dispersing; All medicines are played heat-clearing and toxic substances removing altogether, relieving cough and resolving phlegm, and effect of the sending down the abnormal ascending QI of relievining asthma, is mainly used in treating the diseases such as infectious laryngotracheitis of chicken, infective rhinitis, infectious bronchitis, and curative effect is reliable, and effect is rapid, and easy to use.
The present invention adopts pure natural Chinese herbal medicine, and crude drug is easy to get, and cheap and safety, noresidue are without any side effects to poultry body.Radix Isatidis in prescription, Indigo Naturalis, Radix Scutellariae, Realgar etc. have stronger antipyretic and antidote functions, and according to the research of modern veterinary, it all has inhibitory action more rapidly to the growth and reproduction of antibacterial, virus, mycoplasma; Catechu, the Rhizoma Anemarrhenae, the Radix Stemonae, Borax, Radix Platycodonis, Borneolum Syntheticum have respectively promote the production of body fluid, the effect of lung moistening, sore-throat relieving, cough-relieving, Dingchuan, its mechanism of action is that active drug composition in them can improve C-AMP and C-GMP ratio, excited B-receptor, the phosphodiesterase of drawing up as volatile oil, alkaloid, catechin, adenylate cyclase activating thing philosophy, thus produce eliminate the phlegm fast, antitussive, antiasthmatic effect.
The veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease is prepared into powder by the present invention, and method is simple, easy operating, is suitable for large-scale production and application.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
In the present embodiment, be used for the treatment of the veterinary Chinese medicinal composition of respiratory infectious disease, formed by the crude drug of following weight portion: 600 parts of Radix Isatidis, 600 parts of the Rhizoma Anemarrhenaes, 300 parts of the Radixs Stemonae, 40 parts of Borneolum Syntheticums, 3 parts of Venenum Bufoniss, 200 parts of Boraxs, 10 parts of Indigo Naturaliss, 50 parts of Realgars, 200 parts of Radix Platycodoniss, 300 parts of Radix Scutellariaes, 100 parts, catechu.Preparation method is: accurately get each taste medicine according to formula, after pulverizing, mix, cross 60 mesh sieves, obtain powder by 50g/ bag subpackage.
Usage and consumption: oral dosage: the every 1kg body weight of chicken 10～15mg, once a day, is used in conjunction 1～3 day; Mixed feeding amount: every 100kg feedstuff 1000g, is used in conjunction 1～3 day.
Embodiment 2
In the present embodiment, be used for the treatment of the veterinary Chinese medicinal composition of respiratory infectious disease, formed by the crude drug of following weight portion: 700 parts of Radix Isatidis, 500 parts of the Rhizoma Anemarrhenaes, 400 parts of the Radixs Stemonae, 27 parts of Borneolum Syntheticums, 5 parts of Venenum Bufoniss, 100 parts of Boraxs, 33 parts of Indigo Naturaliss, 35 parts of Realgars, 350 parts of Radix Platycodoniss, 200 parts of Radix Scutellariaes, 150 parts, catechu.Preparation method is: accurately get each taste medicine according to formula, after pulverizing, mix, cross 60 mesh sieves, obtain powder by 50g/ bag subpackage.
Usage and consumption: oral dosage: the every 1kg body weight of chicken 10～15mg, once a day, is used in conjunction 1～3 day; Mixed feeding amount: every 100kg feedstuff 1000g, is used in conjunction 1～3 day.
Embodiment 3
In the present embodiment, be used for the treatment of the veterinary Chinese medicinal composition of respiratory infectious disease, formed by the crude drug of following weight portion: 1000 parts of Radix Isatidis, 400 parts of the Rhizoma Anemarrhenaes, 600 parts of the Radixs Stemonae, 10 parts of Borneolum Syntheticums, 10 parts of Venenum Bufoniss, 100 parts of Boraxs, 50 parts of Indigo Naturaliss, 20 parts of Realgars, 500 parts of Radix Platycodoniss, 100 parts of Radix Scutellariaes, 300 parts, catechu.Preparation method is: accurately get each taste medicine according to formula, after pulverizing, mix, cross 60 mesh sieves, obtain powder by 50g/ bag subpackage.
Usage and consumption: oral dosage: the every 1kg body weight of chicken 10～15mg, once a day, is used in conjunction 1～3 day; Mixed feeding amount: every 100kg feedstuff 1000g, is used in conjunction 1～3 day.
The powder of test example 1-embodiment 1～3 preparation is used for the treatment of the clinical verification that infectious laryngotracheitis of chicken infects
Experimental animal: according to epidemiology, clinical symptoms, pathology cuts open inspection, identification and isolation of pathogen comprehensive diagnos is the sick chicken that infectious laryngotracheitis of chicken infects, choose at random 840, be divided into 7 groups, every group 120, adopt respectively powder and the matched group medicine (erythromycin thiocyanate of embodiment 1～3 preparation, lot number 20110215, every 227g of specification, every 100g is containing erythromycin 500 million international units, produced by company of Guangdong herding development general bureau) treat, and blank group is set, observe the curative effect statistics are cured, effectively and invalid number, calculate effective percentage, the results detailed in following table 1.
Powder and the matched group medicine of administrated method and consumption: embodiment 1,3 preparations all adopt 1% spice, are used in conjunction 5 days; Powder prepared by embodiment 2 is respectively with 1.5%(high dose group), dosage group in 1%(), 0.5%(low dose group) spice, be used in conjunction five days; Blank thing does not add any medicine.
The clinical symptoms of infectious laryngotracheitis of chicken: dyspnea, breathe heavier, time see the mucus of expectoration band blood.Pathology cuts open inspection: larynx hyperemia, edema, in trachea, performance covers dense thick mucus, even curd.Identification and isolation of pathogen: antibacterial culturing feminine gender.
Curative effect judging standard: rehabilitation recovery from illness: medication is after 3 days, and clinical disease disappears, and laying hen laying rate is shown in rise, pathology cuts open inspection without obvious pathological phenomenon; Effective: medication is after 3 days, and clinical disease disappears substantially, spirit, diet, amount of drinking water normal; Invalid: medication is after 3 days, clinical disease with treatment before, dead increasing even.
The therapeutic effect of the each processed group of table 1 to infectious laryngotracheitis of chicken
Conclusion: statistical analysis shows, powder effect to infectious laryngotracheitis of chicken with 1% spice and matched group erythromycin thiocyanate of embodiment～3 preparation, with the comparison of blank group, all there is remarkable therapeutical effect (P < 0.01), and have clinical use meaning.The powder of embodiment～3 preparations is with 1% spice and the comparison of matched group erythromycin thiocyanate, and treating infectious laryngotracheitis of chicken has utmost point significant difference (P < 0.01), and the cure rate of powder and total effective rate are higher than erythromycin thiocyanate.In addition, the powder of embodiment～3 preparations is during with 1% spice, and the cure rate of embodiment 1 and total effective rate are significantly higher than embodiment 2, embodiment 3(P < 0.01).
As known from Table 1, in embodiment 2, cure rate, the total effective rate of high, middle dosage group treatment infectious laryngotracheitis of chicken are close, all higher than low dose group.
Powder prepared by test example 2-embodiment 2 is used for the treatment of infectious laryngotracheitis of chicken and infective rhinitis's mixed infection clinical verification
Clinical symptoms: in chicken farm, Zhengzhou, raise and have Luo Man commodity egg, 220 ages in days, first hen house raised 967, raises 410 for second.Certain at the beginning of 2011 day, appear more than 20 sick chicken suddenly in first hen house, after 2 days, whole chicken is mined massively, and appetite obviously declines, spirit is depressed, one-sided or bilateral nasal sinuses, eyelid swelled, cough, sneeze, constantly get rid of head, dyspnea, laying rate is down to 47% by 85%, mortality rate 2.72%; Second after first hen house morbidity, also unexpected ill chicken occurs, symptom is identical with first.
Pathological anatomy: take from right Mortality chicken and cut open inspection, major lesions is the hyperemia of nose and paranasal sinuses mucosa and swelling, and trachea inner surface covers a large amount of mucus, what have is exudative emulsus grumeleuse, the hyperemia that pulmonary has, other organs show no obvious abnormalities.
Source of disease separates and qualification: sterile working, sterile cotton swab is inserted to nasal cavity or the chicken trachea surface of dying of illness, on preprepared blood agar culture medium, rule respectively, cultivate 24 hours for 37 DEG C, see that having canescence to reveal drips sample, smooth translucent, the colony growth of neat in edge, smear for microscopic examination is the dialister bacterium of polarity dyeing.
Cut open inspection, bacterium colony character, Gram dyeing and form inspection according to epidemiology, clinical symptoms, pathology, make a definite diagnosis this chicken group and suffer from infectious laryngotracheitis and infective rhinitis's mixed infection.
Therapeutic Method and observation of curative effect: taking chicken coop as unit, first hen house is as treatment group, adopt respectively embodiment 2 prepare powder height (1.5% spice), in (1% spice), low dose group (0.5% spice), second hen house as a control group, (every 100g is containing erythromycin 500 million international units for lot number 20110215, every 227g of specification to adopt erythromycin thiocyanate, produced by company of Guangdong herding development general bureau), result of the test refers to following table 2.After stopping with treatment within the Drug therapy phase, the variation of clinical symptoms is observed in timing every day in detail, and accurate recording is cured, effective and invalid number, calculates effective percentage, judges curative effect by efficacy assessment standard.
Curative effect determinate standard: effective: continuous use is after 3 days, and clinical symptoms disappears substantially, spirit, diet, amount of drinking water are still in morbid state; Effectively continuous use is after 3 days, and clinical symptoms still has, spirit, diet, amount of drinking water normal; Invalid: continuous use is after 3 days, and clinical disease ditto still has with the mortality rate before treatment, and pathological changes is with before treating.
The therapeutic effect of the each processed group of table 2 to infectious laryngotracheitis of chicken and infective rhinitis's mixed infection
Conclusion: as can be seen from Table 2, the high, medium and low dosage group that the embodiment of the present invention 2 is prepared powder all has good therapeutic effect to infectious laryngotracheitis and infective rhinitis's mixed infection, cure rate is high, effect rapidly, the cure rate of low dose group is 80%, and the cure rate of middle and high dosage group reaches more than 90%.Statistical analysis shows, the high, medium and low dosage group that embodiment 2 prepares powder extremely significantly (P < 0.01) of difference all and between matched group.
The present invention adopts 3% spice dosage that the powder of embodiment 1～3 preparation is added to and in chicken feedstuff, observes its toxicity, and result has no chicken to be had any extremely, shows that the safety coefficient of Chinese medicine composition of the present invention is large, and toxic action is little.
Claims (3)
1. a veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease, is characterized in that: the crude drug by following weight portion forms: 600～1000 parts of Radix Isatidis, 400～600 parts of the Rhizoma Anemarrhenaes, 300～600 parts of the Radixs Stemonae, 10～40 parts of Borneolum Syntheticums, 3～10 parts of Venenum Bufoniss, 100～200 parts of Boraxs, 10～50 parts of Indigo Naturaliss, 20～50 parts of Realgars, 200～500 parts of Radix Platycodoniss, 100～300 parts of Radix Scutellariaes, 100～300 parts, catechu.
2. the veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease according to claim 1, is characterized in that: the crude drug by following weight portion forms: 700 parts of Radix Isatidis, 500 parts of the Rhizoma Anemarrhenaes, 400 parts of the Radixs Stemonae, 27 parts of Borneolum Syntheticums, 5 parts of Venenum Bufoniss, 100 parts of Boraxs, 33 parts of Indigo Naturaliss, 35 parts of Realgars, 350 parts of Radix Platycodoniss, 200 parts of Radix Scutellariaes, 150 parts, catechu.
3. a preparation method for the veterinary Chinese medicinal composition that is used for the treatment of respiratory infectious disease as claimed in claim 1 or 2, is characterized in that: comprise the steps: accurately to get each taste crude drug according to formula, mix, sieve after pulverizing.
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| 朱连勤等: "中药防治鸡传染性呼吸道疾病的研究现况与展望", 《中兽医学杂志》 * |
| 苏梅等: "中草药防治鸡传染性支气管炎试验观察", 《中兽医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494593A (en) * | 2020-12-31 | 2021-03-16 | 广东高山动物药业有限公司 | Pure traditional Chinese medicine preparation for resisting respiratory syndrome for poultry |
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| CN104162074B (en) | 2017-10-03 |
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