CN104161787A

CN104161787A - Novel application of eucommia ulmoides in preparing medicines

Info

Publication number: CN104161787A
Application number: CN201410375644.9A
Authority: CN
Inventors: 宋振华; 方方; 许翠萍
Original assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Current assignee: Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
Priority date: 2014-08-01
Filing date: 2014-08-01
Publication date: 2014-11-26

Abstract

The invention relates to novel application of eucommia ulmoides. Lotion prepared from eucommia ulmoides has a good beautifying and wrinkle-removing effect.

Description

The new purposes of the Cortex Eucommiae in preparing medicine

Technical field

The present invention relates to medicine, particularly the new purposes of the Cortex Eucommiae in preparing medicine, belongs to medical technical field.

Background technology

The Cortex Eucommiae is that the Eucommiaceae Cortex Eucommiae belongs to perennial deciduous tree, its dry bark is the Chinese medicine Cortex Eucommiae, there is invigorating the liver and kidney, bone and muscle strengthening, the function such as antiabortive, the modern study proof Cortex Eucommiae has antiinflammatory, antiviral, antitumor, defying age, raising body anoxia tolerance, improve and improve body's immunity, reduce the effects such as blood fat, balance adjustment blood pressure and studies have shown that in the last few years that Folium Eucommiae and Cortex Eucommiae had similar chemical composition and pharmacological action.Clinical conventional Folium Eucommiae and Cortex Eucommiae Hypertension, atherosclerotic arteriosclerosis, lumbar muscle strain, poliomyelitis sequela, habitual abortion.

Prior art is all oral by the Cortex Eucommiae or Folium Eucommiae treatment disease, there is no the report of external curing disease, more without the report for the preparation of beautifying wrinkle-removing medicine.

Summary of the invention

The new purposes that the object of this invention is to provide the Cortex Eucommiae, is specifically related to the Cortex Eucommiae and is preparing the new purposes of beautifying wrinkle-removing medicine.

The object of the present invention is achieved like this:

The new purposes of the Cortex Eucommiae, prepares beautifying wrinkle-removing medicine.

The new purposes of the described Cortex Eucommiae, the dosage form of preparing beautifying wrinkle-removing medicine is lotion.

The new purposes of the described Cortex Eucommiae, the concentration of preparing the lotion of beautifying wrinkle-removing medicine is that every 100 milliliters of lotions are equivalent to the Cortex Eucommiae of 5-20 gram.

The described Cortex Eucommiae comprises Cortex Eucommiae and/or Folium Eucommiae.

The new purposes of the Cortex Eucommiae of the present invention, the medicine of preparation has better beautifying wrinkle-removing effect.

Below by test example, further set forth beneficial effect of the present invention.Test example is intended to further illustrate effect of the present invention below, but not restriction of the present invention.

1, physical data: study subject is mainly from volunteer, totally 32 examples, male 14 examples wherein, female's 18 examples, age 40-70 year.

2, test medication: Cortex Eucommiae lotion, get Cortex Eucommiae, decoct with water twice, add for the first time 10 times of water gagings, decoct 1 hour, add for the second time 8 times of water gagings, decoct 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, and sterilizing, adds appropriate water, obtains 5% Cortex Eucommiae lotion.

3, study subject is selected

3.1 wrinkle of skin grade scales: according to Glogau typing, wrinkle of skin is carried out to classification, grade scale is as follows:.

I level is without wrinkle, and early stage photoaging, has or without slight pigmentation, when histrionic muscles is movable, rare wrinkle occurs age 30-40 year; There is the wrinkle that tiny table is shallow.

II level when motion wrinkle, arrive moderate photoaging in early days, age 40-50 year, and visible thin and shallow wrinkle when histrionic muscles is movable, activity stops wrinkle disappearance.

Wrinkle when III level is static, photoaging in late period, age 50-60 year, obvious pigment anomaly, it is visible that shallow to medium wrinkle when static, quantity is medium, tractive and while stretching wrinkle both sides skin wrinkle disappear.

IV level only has wrinkle, 60-70 year, and yellow grey skin, thick deep wrinkle while being entirely static state, also not exclusively disappears during the skin of tractive both sides, has or without skinfold.

3.2 inclusive criterias: 1. meet wrinkle of skin grade scale; 2. age 40-70 year.

3.3 exclusion standards: 1. allergic constitution and to medicine and silica gel composition allergy sufferers; 2. in 3 months, apply other reduce wrinkles method persons such as too drastic light; 3. face has acute inflammation or other skin patient.

3.4 reject and the standard that comes off: 1. not medication in accordance with regulations, cannot judge curative effect person; 2. exit voluntarily or do not complete the regulation observation period and the judgement person that affects the treatment.

4, method

Using method: use Cortex Eucommiae lotion to wash one's face, every day, sooner or later respectively once the test period was 3 months, all took pictures and carried out wrinkle of skin integral estimation before and after test.

4.3 wrinkle integral estimations: test before and after all under unified standard conditions, take outer canthus to the region between hairline (1st district) and forehead (2nd district) photo, by the wrinkle on the standard control sheet of working out in advance, evaluate, then 1st district and 2nd district of two photos before and after viewing test, and recording two wrinkle quantity, length in region, wrinkle integration Shi Jiang 1st district and every, 2 positions, district wrinkle length are divided the product accumulation with the wrinkle number in each region.

5, result

Wrinkle integration before and after test obviously reduces, and the results are shown in Table 1.

Wrinkle integral result before and after table 1 test.

Wrinkle integration before test	Wrinkle integration after test	Difference
			64.53±33.18	29.57±16.42	34.69±12.45

The specific embodiment

embodiment 1

Get Cortex Eucommiae, decoct with water twice, add for the first time 8 times of water gagings, decoct 1 hour, add for the second time 8 times of water gagings, decoct 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, is concentrated into, and sterilizing, adds appropriate water, obtains 10% Cortex Eucommiae lotion.

embodiment 2

Get Folium Eucommiae, decoct with water twice, add for the first time 10 times of water gagings, decoct 1 hour, add for the second time 8 times of water gagings, decoct 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, is concentrated into, and sterilizing, adds appropriate water, obtains 20% Cortex Eucommiae lotion.

embodiment 3

Folium Eucommiae and the Cortex Eucommiae of getting equivalent, decoct with water twice, adds for the first time 8 times of water gagings, decocts 1 hour, adds for the second time 6 times of water gagings, decocts 1 hour, merges medicinal liquid, and medicinal liquid filters, and gets filtrate, is concentrated into, and sterilizing, adds appropriate water, obtains 20% Cortex Eucommiae lotion.

embodiment 4

Get the Folium Eucommiae of 1 part and the Cortex Eucommiae of 3 parts, add water and add 10 times of water gagings, soak 3 days, medicinal liquid filters, and gets filtrate, adds appropriate sodium benzoate, obtains 10% Cortex Eucommiae lotion.

Claims

1. the new purposes of the Cortex Eucommiae, is characterized in that: by the Cortex Eucommiae, prepare beautifying wrinkle-removing medicine.

2. according to the new purposes of the Cortex Eucommiae of claim 1, it is characterized in that: the dosage form of preparing beautifying wrinkle-removing medicine by the Cortex Eucommiae is lotion.

3. according to the new purposes of the Cortex Eucommiae of claim 1 or claim 2, it is characterized in that: the concentration of preparing the lotion of beautifying wrinkle-removing medicine by the Cortex Eucommiae is that every 100 milliliters of lotions are equivalent to the Cortex Eucommiae of 5-20 gram.