CN1041592A - 磺内酰胺磺胺衍生物及除草剂 - Google Patents
磺内酰胺磺胺衍生物及除草剂 Download PDFInfo
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Abstract
一种具有分子式I的磺内酰胺衍生物或其农用盐类，式(I)中Q的结构如摘要附图所示，在Q的分子式中，R1，R2，R3，R4和R5各自为氢、取代或未被取代的烃基、硝基、氰基、氨基或卤素等；X是氧或硫；M是氢、低级链烃基，而G的结构如上图所示，其中A为CH或氮，B和C各自为取代或未取代的烷基、烷氧基或卤素等。
Description
本发明涉及一种新颖的磺内酰胺磺胺(Sultamsulfonamide)衍生物及其农业上有用的盐类，以及以这类衍生物及其盐作为活性组分的除草剂。
除草剂在防护诸如稻()、小麦()、玉米( )、大豆( )、棉花( .)和甜菜( )之类重要作物免受杂草侵害，以及增加这类作物的产量方面是必不可少的。近来人们特别希望能研制出一种选择性除草剂，这种除草剂能够选择性地控制杂草，而且即使同时施加到共同生长在一块田中的作物和杂草的叶子上，对作物亦无不利影响。另外，为了防止环境污染，降低运输和施用的费用，人们多年来一直在试图研制一种能在尽可能低的剂量下显现出高除草效能的化合物，实际上具有这类性质的一些化合物现已被用作选择性除草剂。然而，具有这类性质的新颖化合物仍是需要的。
在已有技术中具有类似于本发明之化合物的结构者，如在日本未审查的专利公开号48973/1985中所揭示的一种具有磺胺结构的脲类化合物。然而，具有类似于本发明之化合物的磺内酰胺结构的化合物尚未为人们所知，它们是一种新颖的化合物。
本发明者们多年来进行了大量的研究，已研制出一种对重要作物具有选择性的化合物，并对许多化合物的除草性能作了研究，目的在于试图找到一种具有高度除草活性和选择性的化合物。终于他们发现了一种具有下述分子式
的磺内酰胺磺胺衍生物或其农业上有用的盐类，式中Q为
或
其中R1、R2、R3、R4和R5各自为氢、C1-C6的烷基、C2-C6的烯基、C2-C6的炔基、卤素、三氟甲基、硝基、氰基、氨基、C1-C6的烷氧基、苯氧基(倘若该苯氧基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基所取代)、C1-C6的烷硫基、苯硫基(倘若该苯硫基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基所取代)、C1-C6的烷基磺酰基、苯磺酰基(倘若该苯磺酰基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基所取代)、C1-C6的烷基羰基、羧酸、C1-C6的烷氧基羰基、C1-C6的单烷基氨基羰基、C1-C6的双烷基氨基羰基、C2-C6的酰氨基、C1-C6的卤代烷基、被氰基取代的C1-C6的烷基、被羟基取代的C1-C6的烷基、被氨基取代的C1-C6的烷基、被C1-C6的烷氧基取代的C1-C6的烷基、被C1-C6的卤代烷氧基取代的C1-C6的烷基、被C1-C6的烷硫基取代的C1-C6烷基、被C1-C6的烷基磺酰基取代的C1-C6的烷基、被C1-C6的烷基羰基取代的C1-C6的烷基、被羧酸取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C1-C6的烷基、被C2-C6的烯氧基取代的C1-C6的烷基、被C2-C6的炔氧基取代的C1-C6的烷基、被C2-C6的酰氨基取代的C1-C6的烷基、被C1-C6的烷基磺酰氧基取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C2-C6的烯基、被氰基取代的C2-C6的炔基、苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)或被苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)取代的C1-C6的烷基；X是氧或硫；M是氢、C1-C6的烷基、C2-C6的烯基或C2-C6的炔基；而G是式中A是
或氮，而B和C各自是C1-C4的烷基、C1-C4的烷氧基、C1-C4的卤代烷基、C1-C4的卤代烷氧基、卤素或C1-C4的单烷基氨基、这种磺内酰胺磺胺衍生物及其盐在土壤处理和叶子处理中对许多种杂草都有极强的除草活性，并对小麦( )、玉米( )、棉花( .)、大豆()、甜菜( )、稻( )等具有高度的安全性。本发明已在这一发现的基础上得以完成。另一方面，与普通的除草剂相比，本发明之化合物可在极低的剂量下显现出高度的除草活性，可用于果园或非农田的除草剂。
本发明的分子式I之化合物可方便地用下述反应图解1至4中任一种方式制备。反应图解I
在上式中Q、G、X和M的定义均如前述。
亦即将磺内酰胺磺酰异(硫)氰酸酯衍生物(IV)溶于完全无水的惰性溶剂，如二噁烷、乙腈和丙酮中，并加入嘧啶或分子式V的三嗪衍生物。通常在搅拌下反应即迅速地进行，由此得到本发明的分子式I之化合物。当反应几乎不能继续进行时，则可加入少量诸如三乙胺、三亚乙基二胺、吡啶、醇钠、氢化钠或碳酸钾之类合适的碱，由此反应将迅速地进行。反应图解2在上式中，Q、G、X和M的定义同上，而Y是
的烷基或苯基。
亦即，在诸如碳酸钾之类的碱存在下，使磺内酰胺磺胺衍生物(II)与(硫代)氯甲酸酯和(硫代)碳酸酯在诸如丙酮、甲基·乙基酮或乙腈之类溶剂中进行反应，得到化合物(III)。然后将化合物(III)与化合物(V)在诸如甲苯之类溶剂中加热，得到本发明的化合物(I)。反应图解3
在上式中，Q、G、Y和M的定义均如上述。
使磺内酰胺(VI)与N-氯磺酰氨基甲酸苯酯(VII：Y＝苯基)或N-氯磺酰氨基甲酸烷酯(VII：Y＝低级烷基)进行反应，其中相对于1摩尔的磺内酰胺(VI)，氨基甲酸酯衍生物(VII)的用量为0.5-3.0摩尔，其中尤以0.9-1.2摩尔为较佳。
反应温度可选择在-50-100℃的范围内，尤以20-30℃为较佳。
上述反应可采用各种的碱进行。碱的用量相对于1摩尔的磺内酰胺(VI)而言，为0.5-4.0摩尔。适合用于本发明的这类碱包括诸如氢化钠之类的金属氢化物，诸如乙醇钠之类的金属醇盐，诸如正丁基钠之类的烷基金属，诸如三乙胺、吡啶或1，8-二氮二杂环[5，4，0]-7-十一碳烯(DBU)之类的有机碱，或者诸如氢氧化钾或氢氧化钠之类的无机碱。其中特别以金属氢化物为佳。
适用于本发明的溶剂，此处可以提一下的是一种对该反应呈惰性的溶剂，例如芳烃(如苯、甲苯或二甲苯)，卤代烃(如二氯甲烷、氯仿或四氯化碳)，醚(如乙醚、异丙醚、二噁烷或四氢呋喃)，腈(如乙腈或丙腈)、烃(如石油醚、石油苯或己烷)、酮(如丙酮或甲基·乙基酮)、酯(如乙酸乙磺)或酰胺((如二甲基甲酰胺、二甲基乙酰胺或六甲基磷酰三胺)。上述这些溶剂可以单独地或结合使用。其中特别以醚或酰胺类为佳。
然而将N-磺内酰胺磺酰基氨基甲酸苯酯(III：X＝0，Y＝苯基)或N-磺内酰胺磺酰基氨基甲酸烷基酯(III：X＝0，Y＝低级烷基)和化合物(V)在诸如苯或甲苯之类的溶剂中加热，由此得到本发明的化合物I。反应图解4
在上式中，Q、G、Y和M的定义均如前述。
亦即，在无机碱(如碳酸钾)或有机碱(如三乙胺或DBU)的存在下，使磺内酰胺磺胺衍生物(II)与氨基甲酸酯衍生物(VIII)在诸如丙酮、乙腈或二噁烷之类的溶剂中进行反应，以得到本发明的化合物(I)。反应图解5在上式中，Q和G的定义均如前述。
亦即，在无机碱(如碳酸钾)或有机碱(如三乙胺或DBU)存在下，使磺内酰胺磺胺衍生物(II)与异硫氰酸酯衍生物(IX)在丙酮、乙腈或二噁烷之类的溶剂中进行反应，以得到本发明的化合物(I)。
在分子式(I)中，本发明的化合物(其中M是C1-C6的烷基、C2-C6的烯基或C2-C6的炔基)可通过反应图解1，2，3或4进行制备，也可直接将化合物(I：M＝
)进行烷基化，烯基化或炔基化而制得。
在反应图解1中用作起始物料的磺内酰胺磺酰异(硫)氰酸酯衍生物(IV)可按照欧洲专利公开号871780或日本待批专利公开号13266/1980中所揭示的方法，从磺内酰胺衍生物(II)制得。
另外，磺内酰胺磺酰基异氰酸酯(IV：X＝0)也可按日本待批专利公开号81320/1974中所揭示的方法，用反应图解6来制得。反应图解6
在上式中，Q的定义同前。
用作本发明中间体的磺内酰胺磺胺衍生物(II)、N-磺内酰胺磺酰基(硫)氨基甲酸苯酯(III：Y＝苯基)和N-磺内酰胺磺酰基(硫)氨基甲酸烷基酯(III：Y＝低级烷基)也是新颖的化合物。磺。内酰胺磺胺衍生物(II)可通过反应图解7或8，而从磺内酰胺衍生物(VI)制得。反应图解7
上式中，Q的定义同前。在反应图解7中，叔丁基采用三氟乙酸去除。三氟乙酸的用量可任意地选自等摩尔至过量。三氟乙酸可被用作溶剂。反应温度可选自-50℃至80℃的范围，其中以-20℃至30℃的范围为较佳。
若在反应中使用溶剂，则可使用对该反应呈惰性的溶剂，例如苯、甲苯或二甲苯之类的芳族烃，诸如二氯甲烷、氯仿或四氯化碳之类的卤代烃，诸如乙醚、异丙醚、二噁烷或四氢呋喃之类的醚，诸如乙腈或丙腈之类的腈，诸如石油醚，石油苯或己烷之类的烃，诸如丙酮或甲基·乙基酮之类的酮，诸如乙酸乙酯之类的酯，或诸如二甲基甲酰胺、二甲基乙酰胺或六甲基磷酰三胺之类的酰胺。这些溶剂可以单独使用，也可以结合使用。反应图解8
上式中，Q的定义同前。
在反应图解8中，2-甲基-2-丙醇与异氰酸氯磺酰酯的反应可按其已知的方法(如在日本待批专利公开号101323/1975中揭示的方法)进行制备。
在磺内酰胺(VI)与叔丁基氨磺酰氯的反应中，后者的用量为0.5-3.0摩尔，其中尤以0.9-1.2摩尔的范围为较佳。
反应温度可选自-50℃至100℃的范围，其中以-20℃至30℃为较佳。
上述反应可采用各种碱进行。碱的用量相对于1摩尔的磺内酰胺(VI)而言为0.5-4.0摩尔，其中以0.8-2.2摩尔的范围为较佳。适合于此处使用的碱可列举如下：诸如氢化钠之类的金属氢化物，诸如乙醇钠之类的金属醇盐；诸如正丁基锂之类的烷基金属，诸如三乙胺、吡啶或1，8-二氮二杂环[5，4，0]-7-十一烯(DBU)之类的有机碱，或者诸如氢氧化钾或氢氧化钠之类的无机碱。其中特别以金属氢化物为较佳。
适用于本发明的溶剂是一种对该反应呈惰性的溶剂，例如苯、甲苯或二甲苯之类的芳族烃，诸如二氯甲烷、氯仿或四氢化碳之类的卤代烃，诸如乙醚、异丙醚、二噁烷或四氢呋喃之类的醚，诸如乙腈或丙腈之类的腈，诸如石油醚、石油苯或己烷之类的烃，诸如丙酮或甲基·乙基酮之类的酮，诸如乙酸乙酯之类的酯，或者诸如二甲基甲酰胺、二甲基乙酰胺或六甲基磷酰三胺之类的酰胺。上述这些溶剂可以单独或结合使用，其中特别以醚或酰胺为较佳。
在反应图解3中，N-氯磺酰基氨基甲酸苯酯(VII：Y＝苯基)和N-氯磺酰基氨基甲酸烷基酯(VII：Y＝低级烷基)可由已知的方法(如在“Chemishe Berichte，Vol.96，p.56(1963)中所揭示的方法)制备。
用作上述反应中起始物料的磺内酰胺(VI)可参照下述文献方便地制备Journal of Organic Chemistry，Vol.28，p.3537(1963)，Journal of Organic Chemistry，Vol.48，p.537(1983)，Tetrahedron Letters，Vol.24，p2131(1983)，ChemicalAbstracts，Vol.62，14484g(1965)和German Patent No·1300933。
制备1，4-丁磺内酰胺的代表性例子如下述反应图解9所示。反应图解9
以下将参照实施例对本发明作进一步详细描述。然而，应该明白，本发明绝非限于这些具体的例子。例1 1，4丁磺内酰胺-N-磺胺的制备
1)在室温下，将10克(74毫摩尔)1，4-丁磺内酰胺溶于50毫升无水四氢呋喃(THF)中所组成的溶液加到含有3.23克(74摩尔)氢化钠(55％浓度)的50毫升无水四氢呋喃中，并将此混合物在室温下搅拌14小时。
然后将反应体系冷却至-70℃，并向其内滴加14.0克(81.6毫摩尔)叔丁基氨磺酰氯。此后，温度逐渐上升至室温，并在室温下继续搅拌24小时。
将反应混合物倾入碳酸氢钠水溶液和冰的混合物中，并用浓盐酸将pH调节至6，接着用氯仿萃取反应产物。
氯仿层用水洗涤后，用无水硫酸镁干燥。然后在减压下蒸出溶剂，由此所得的残留物用正已烷洗涤，最终得到5.3克所需要的N-叔丁基氨磺酰-1，4-丁磺内酰胺，熔点为87-88℃。
2)将5.2克(19.3毫摩尔)N-叔丁基氨磺酰-1，4-丁磺内酰胺加到80毫升三氟乙酸中，并在室温下将此混合物搅拌2小时。然后在减压下蒸出三氟乙酸。由此得到的固体粗制品经二乙醚和氯仿洗涤后，得到1.8克所需的1，4-丁磺内酰胺-N-磺胺，熔点为130-131℃。
按例1所述的同样方法制成的化合物的结构和物理性质如下所示：
熔点：152-153℃
熔点：137-138℃
熔点：113-114℃
熔点：111-112℃例2 N-(2，4-丁磺内酰胺-N-磺酰基)氨基甲酸苯酯的制备
将1.0克(4.67毫摩尔)2，4-丁磺内酰按-N-磺胺溶于10毫升无水乙腈中，并加入970毫克(7.02毫摩尔)无水碳酸钾和880毫克(5.62毫摩尔)氯甲酸苯酯。然后将此混合物在加热下同流1小时。
冷却后，将反应混合物倾入含有1.8克浓盐酸的100毫升冰水中，并用氯仿萃取。氯仿层经水洗涤后，用无水硫酸镁干燥。接着蒸出溶剂，由此所得的残留物经异丙醚洗涤后，最终得到1.2克所需的N-(2，4-丁磺内酰胺-N-磺酰基)氨基甲酸苯酯，熔点为125-126℃。例3 N-(1-甲氧基羰基-1，3-丙磺内酰胺-N-磺酰基)氨基甲酸苯酯的制备
在冰冷却下，将5.6克(31.3毫摩尔)1-甲氧基羰基-1，3-丙磺内酰胺溶于20毫升无水四氢呋喃中所组成的溶液加到含有2.87克(65.8毫摩尔)氢化钠(55％)的100毫升无水四氢呋喃中，然后在室温和氯气氛下，将混合物搅拌14小时。
将反应体系冷却至0℃后，向其滴加含有8.1克(34.4毫摩尔)N-氯磺酰基氨基甲酸苯酯的30毫升无水四氢呋喃溶液。接着将温度逐渐提高至室温，并在室温下搅拌3小时。
将反应混合物倾入含有10.4克浓盐酸的500毫升冰水中，并用二乙醚萃取。二乙醚层相继用水和饱和氯化钠水溶液洗涤后，用无水硫酸镁干燥。然后在减压下蒸出溶剂。由此所得的残留物用苯洗涤后，最终得到10.0克所需的N-(1-甲氧基羰基-1，3-丙磺内酰胺-N-磺酰基)氨基甲酸苯酯，熔点为84-85℃。
按例2和例3所述的同样方式制备得到的化合物的结构和物理性质如下所示：
(固体)
(油状)
(油状)
熔点：70-71℃
熔点：92-93℃
(油状)
(油状)
(油状)
熔点：144-145℃
熔点：141-142℃
熔点：149-150℃
熔点：128-129℃
(油状)
熔点：112-113℃
熔点：128-129℃
(油状)
(油状)
(油状)
熔点：70-73℃
熔点：147-149℃
(固体)
熔点：125-128℃
熔点：114-117℃例4
1-(1，4-丁磺内酰胺-N-磺酰基)-3-(4，6-二甲氧基嘧啶-2-基)脲的制备
(1号化合物)
在由400毫克(1.87毫摩尔)1，4-丁磺内酰胺-N-磺胺、515毫克(1.87毫摩尔)N-(4，6-二甲氧基嘧啶-2-基)氨基甲酸苯酯和10毫升无水乙腈所组成的混合物中，加入285毫克(1.87毫摩尔)1，8-二氮杂环[5，4，0]-7-十一碳烯(DBU)，并将此混合物在室温下搅拌15分钟。然后在反应混合物中加入50毫升冰水，并进行过滤。滤液用浓盐酸酸化。沉淀析出的固体通过过滤收集，并相继用水和乙腈洗涤，干燥后得到0.42克所需的1-(1，4-丁磺内酰胺-N-磺酰基)-3-(4，6-二甲氧基嘧啶-2-基)脲，熔点为173-174℃。例5 1-(1-甲氧基羰基-1，3-丙磺内酰胺-N-磺酰基-3-(4，6-二甲氧基嘧啶-2-基)-脲
(2号化合物)
将1.9克(5.03毫摩尔)N-(1-甲氧基羰基-1，3-丙磺内酰胺-N-磺酰基)氨基甲酸酯、780毫克(5.03毫摩尔)2-氨基-4，6-二甲氧基嘧啶和20毫升无水苯所组合的混合物加热回流20分钟。冷却后，沉淀析出的固体通过过滤进行收集，由此得到1.1克所需的1-(1-甲氧基羰基-1，3-丙磺内酰胺-N-磺酰基)-3-(4，6-二甲氧基嘧啶-2-基)脲，熔点为173-174℃。例6 1-(1，4-丁磺内酰胺-N-磺酰基)-3-(4，6-二甲氧基嘧啶-2-基)硫脲
(3号化合物)
将214毫克(1.0毫摩尔)1，4-丁磺内酰胺-N-磺胺和207毫克(1.05毫摩尔)4，6-二甲氧基-2-异硫氰酸根合嘧啶溶于10毫升无水丙酮中，然后加入145毫克(1.05毫摩尔)无水碳酸钾，并将上述混合物在室温下搅拌15小时。沉淀析出的固体通过过滤予以收集，并使之再悬浮在30毫升水中。用稀盐酸将悬浮液的pH调节至1-2，再用过滤的方法收集沉淀的固体，后者经水洗涤后，再用少量的乙腈和二乙醚洗涤，最终得到190毫克1-(1，4-丁磺内酰胺-N-磺酰)-3-(4，6-二甲氧基嘧啶-2-基)硫脲，熔点为215-216℃。例7 1-(2，4-丁磺内酰胺-N-磺酰基)-3-甲基-3-(4，6-二甲氧基嘧啶-2-基)脲
(37号化合物)
将470毫克(1.19毫摩尔)1-(2，4-丁磺内酰胺-N-磺酰基)-3-(4，6-二甲氧基嘧啶-2-基)脲溶于10毫升无水四氢呋喃中，然后相继加入270毫克(2.41毫摩尔)叔丁醇钾和270毫克(2.14毫摩尔)硫酸二甲酸。上述反应混合物在室温下搅拌3小时后，在减压下蒸出溶剂。接着依次加入20毫升5％的盐酸和少量乙醇。沉淀析出的固体通过过滤予以收集，再继续用水和少量二乙醚洗涤，最终得到270毫克1-(2，4-丁磺为酰胺-N-磺酰基)-3-甲基-3-(4，6-二甲氧基嘧啶-2-基)脲，熔点为139-140℃。
按例4，5所述的同样方式所制备的化合物的结构和物理性质如下所示：
(4号化合物) 熔点：153-154℃
(5号化合物) 熔点：165-166℃
(6号化合物) 熔点：159-160℃
(7号化合物) 熔点：190-191℃
(8号化合物) 熔点：180-181℃
(9号化合物) 熔点：172-173℃
(10号化合物) 熔点：170-171℃
(11号化合物) 熔点：156-157℃
(12号化合物) 熔点：159-160℃
(13号化合物) 熔点：162-163℃
(14号化合物) 熔点：173-174℃
(15号化合物) 熔点：160-161℃
(16号化合物) 熔点：159-160℃
(17号化合物) 熔点：174-175℃
(18号化合物) 熔点：156-157℃
(19号化合物) 熔点：140-142℃
(20号化合物) 熔点：154-155℃
(21号化合物) 熔点：162-164℃
(22号化合物) 熔点：118-120℃
(23号化合物) 熔点：138-140℃
(24号化合物) 熔点：142-145℃
(25号化合物) 熔点：182-183℃
(26号化合物) 熔点：188-189℃
(27号化合物) 熔点：156-158℃
(28号化合物) 熔点：155-158℃
(29号化合物) 熔点：157-158℃
(30号化合物) 熔点：173-174℃
(31号化合物) 熔点：158-159℃
(32号化合物) 熔点：158-159℃
(33号化合物) 熔点：143-144℃
(34号化合物) 熔点：171-172℃
(35号化合物) 熔点：150-152℃
(36号化合物) 熔点：199-200℃
(38号化合物) 熔点：178-179℃
(39号化合物) 熔点：179-180℃
(40号化合物) 熔点：176-177℃
(41号化合物) 熔点：166-167℃
(42号化合物) 熔点：136-139℃
(43号化合物) 熔点：174-175℃
(44号化合物) 熔点：179-180℃
(45号化合物) 熔点：157-158℃
(46号化合物) 熔点：183-184℃
(47号化合物) 熔点：178-180℃
(48号化合物) 熔点：137-140℃
(49号化合物) 熔点：179-180℃
(50号化合物) 熔点：163-164℃
(51号化合物) 熔点：174-175℃
(52号化合物) 熔点：161-166℃
(53号化合物) 熔点：189-190℃
(54号化合物) 熔点：143-144℃
(55号化合物) 熔点：140-141℃
(56号化合物) 熔点：168-169℃
(57号化合物) 熔点：171-172℃
(58号化合物) 熔点：191-192℃
(59号化合物) 熔点：157-159℃
(60号化合物) 熔点：173-174℃
(61号化合物) 熔点：172-173℃
(62号化合物) 熔点：172-174℃
(63号化合物) 熔点：171-174℃
(64号化合物) 熔点：177-178℃
(65号化合物) 熔点：170-171℃
(66号化合物) 熔点：170-171℃
(67号化合物) 熔点：166-167℃
(68号化合物) 熔点：169-170℃
(69号化合物) 熔点：168-169℃
(70号化合物) 熔点：179-180℃
(71号化合物) 熔点：149-150℃
(72号化合物) 熔点：168-169℃
(73号化合物) 熔点：168-170℃
(74号化合物) 熔点：160-161℃
(75号化合物) 熔点：158-160℃
(76号化合物) 熔点：157-160℃
(77号化合物) 熔点：166-167℃
(78号化合物) 熔点：158-159℃
(79号化合物) 熔点：159-160℃
(80号化合物) 熔点：148-151℃
包括在本发明内的化合物的例子，以及由上述实施例所制备的化合物示于表1至表10。然而，应当明白，本发明决非限于这类具体的化合物。
表中参照符号的含义如下：
Me：甲基，Et：乙基，Pr-n：正丙基，Pr-i：异丙基，Bu-n：正丁基，Bu-sec：仲丁基，Bu-t：叔丁基，Pen-n：正戊基，而Ph：苯基。Gn的含义如下：Ga＝G1～G13，Gb＝G1～G6，Gc＝G1～G3 
(Y＝Me，Et，Pr-n，Bu-n or Ph)
R1 R2 R3
H H H
H Me H
H Et H
H Pr-n H
H Pr-i H
H Bu-n H
Me H H
Et H H
Pr-n H H
Pr-i H H
Bu-n H H
H Me Me
H Me Et
H Me Pr-n
H Me Pr-i
H Me Bu-n
H Et Et
H Et Pr-n
H Et Pr-i
H Pr-n Pr-n
Me H H
Me Me H
Me Et H
Me Pr-n H
Me Pr-i H
Me Bu-n H
Et H H
Et Me H
Et Et H
Et Pr-n H
Et Pr-i H
R1 R2 R3
Et Bu-n H
Pr-n H H
Pr-n Me H
Pr-n Et H
Pr-n Pr-n H
Pr-n Pr-i H
Pr-n Bu-n H
Pr-i H H
Pr-i Me H
Pr-i Et H
Pr-i Pr-n H
Pr-i Pr-i H
Pr-i Bu-n H
Bu-n H H
Bu-n Me H
Bu-n Et H
Bu-n Pr-n H
Bu-n Pr-i H
Bu-n Bu-n H
Me Me Me
Me Me Et
Me Me Pr-n
Me Me Pr-i
Me Et Et
Me Et Pr-n
Me Et Pr-i
Et Me Me
Et Me Et
Et Me Pr-n
Et Me Pr-i
Et Et Et
Et Et Pr-n
Et Et Pr-i
Pr-n Me Me
Pr-n Me Et
Pr-n Me Pr-n
Pr-n Me Pr-i
R1 R2 R3
Pr-n Et Et
Pr-n Et Pr-n
Pr-n Et Pr-i
Pr-i Me Me
Pr-i Me Et
Pr-i Me Pr-n
Pr-i Me Pr-i
Pr-i Et Et
Pr-i Et Pr-n
Pr- Et Pr-i
H Ph H
H Ph-2-Cl H
H Ph-3-Cl H
H Ph-4-Cl H
H CH2Ph H
Ph H H
Ph-2-Cl H H
Ph-3-Cl H H
Ph-4-Cl H H
CH2Ph H H
Me Ph H
Me Ph-2-Cl H
Me Ph-3-Cl H
Me Ph-4-Cl H
Me CH2Ph H
Et Ph H
Et Ph-2-Cl H
Et Ph-3-Cl H
Et Ph-4-Cl H
Et CH2Ph H
Pr-n Ph H
Pr-n Ph-2-Cl H
Pr-n Ph-3-Cl H
Pr-n Ph-4-Cl H
Pr-n CH2Ph H
Ph Me H
Ph-2-Cl Me H
Ph-3-Cl Me H
Ph-4-Cl Me H
R1 R2 R3
CH2Ph Me H
Ph Et H
Ph-2-Cl Et H
Ph-3-Cl Et H
Ph-4-Cl Et H
CH2Ph Et H
Ph Pr-n H
Ph-2-Cl Pr-n H
Ph-3-Cl Pr-n H
Ph-4-Cl Pr-n H
CH2Ph Pr-n H
(Y＝Me，Et，Pr-n，Bu-n or Ph)
R1 R2 R3 R4
H H H H
Me H H H
H Me H H
H H Me H
Et H H H
H Et H H
H H Et H
Pr-n H H H
H Pr-n H H
H H Pr-n H
Pr-i H H H
H Pr-i H H
H H Pr-i H
Bu-n H H H
H Bu-n H H
H H Bu-n H
H H Me Me
Me H Me Me
H Me Me Me
Et H Me Me
H Et Me Me
Pr-n H Me Me
H Pr-n Me Me
Pr-i H Me Me
H Pr-i Me Me
Bu-n H Me Me
H Bu-n Me Me
Me Me Me Me
Me Et Me Me
Me Pr-n Me Me
R1 R2 R3 R4
Me Bu-n Me Me
Et Me Me Me
Et Et Me Me
Et Pr-n Me Me
Et Bu-n Me Me
Pr-n Me Me Me
Pr-n Et Me Me
Pr-n Pr-n Me Me
Pr-n Bu-n Me Me
Bu-n Me Me Me
Bu-n Et Me Me
Bu-n Pr-n Me Me
Bu-n Bu-n Me Me
F H Me Me
Cl H Me Me
Br H Me Me
I H Me Me
CH＝CH2 H Me Me
CH2CH＝CH2 H Me Me
C≡CH H Me Me
CH2C≡CH H Me Me
CH2F H Me Me
CHF2 H Me Me
CN H Me Me
NH2 H Me Me
NHCOMe H Me Me
CH2NH2 H Me Me
CH2NHCOMe H Me Me
CH2OCHF2 H Me Me
CH2OCF3 H Me Me
CF3 H Me Me
NO2 H Me Me
OMe H Me Me
OEt H Me Me
OPr-n H Me Me
OBu-n H Me Me
OPen-n H Me Me
SMe H Me Me
SEt H Me Me
SPr-n H Me Me
R1 R2 R3 R4
SBu-n H Me Me
SPen-n H Me Me
SO2Me H Me Me
SO2Et H Me Me
SO2Pr-n H Me Me
COMe H Me Me
COEt H Me Me
COPr-n H Me Me
CO2H H Me Me
CO2Me H Me Me
CO2Et H Me Me
CO2Pr-n H Me Me
CO2Bu-n H Me Me
CO2Pen-n H Me Me
CH2Cl H Me Me
CH2Br H Me Me
CH2I H Me Me
CH2CF3 H Me Me
CH2CN H Me Me
CH2OH H Me Me
CH2OMe H Me Me
CH2OEt H Me Me
CH2OPr-n H Me Me
CH2SMe H Me Me
CH2SEt H Me Me
CH2SPr-n H Me Me
CH2SO2Me H Me Me
CH2SO2Et H Me Me
CH2SO2Pr-n H Me Me
CH2COMe H Me Me
CH2COEt H Me Me
CH2COPr-n H Me Me
CH2CO2H H Me Me
CH2CO2Me H Me Me
CH2CO2Et H Me Me
CH2CO2Pr-n H Me Me
CH2OCH2CH＝CH2 H Me Me
CH2OCH2C≡CH H Me Me
CH＝CHCO2Me H Me Me
CH＝CHCO2Et H Me Me
R1 R2 R3 R4
CH＝CHCO2Pr-n H Me Me
CH＝CHCN H Me Me
Ph H Me Me
CH2Ph H Me Me
OPh H Me Me
SPh H Me Me
SO2Ph H Me Me
CONHMe H Me Me
CONHEt H Me Me
CONHPr-n H Me Me
CONHPr-i H Me Me
CONHBu-n H Me Me
CONHBu-sec H Me Me
CONHBu-t H Me Me
CON(Me)2H Me Me Me
CON(Et)2 H Me Me
CON(Pr-n)2 H Me Me
H F Me Me
H Cl Me Me
H Br Me Me
H I Me Me
H CH＝CH2 Me Me
H CH2CH＝CH2 Me Me
H C≡CH Me Me
H CH2C≡CH Me Me
H CH2F Me Me
H CHF2 Me Me
H CN Me Me
H NH2 Me Me
H NHCOMe Me Me
H CH2NH2 Me Me
H CH2NHCOMe Me Me
H CH2OCHF2 Me Me
H CH2OCF3 Me Me
H CF3 Me Me
H NO2 Me Me
H OMe Me Me
H OEt Me Me
H OPr-n Me Me
H OBu-n Me Me
R1 R2 R3 R4
H OPen-n Me Me
H SMe Me Me
H SEt Me Me
H SPr-n Me Me
H SBu-n Me Me
H SPen-n Me Me
H SO2Me Me Me
H SO2Et Me Me
H SO2Pr-n Me Me
H COMe Me Me
H COEt Me Me
H COPr-n Me Me
H CO2H Me Me
H CO2Me Me Me
H CO2Et Me Me
H CO2Pr-n Me Me
H CO2Bu-n Me Me
H CO2Pen-n Me Me
H CH2Cl Me Me
H CH2Br Me Me
H CH2I Me Me
H CH2CF3 Me Me
H CH2CN Me Me
H CH2OH Me Me
H CH2OMe Me Me
H CH2OEt Me Me
H CH2OPr-n Me Me
H CH2SMe Me Me
H CH2SEt Me Me
H CH2SPr-n Me Me
H CH2SO2Me Me Me
H CH2SO2Et Me Me
H CH2SO2Pr-n Me Me
H CH2COMe Me Me
H CH2COEt Me Me
H CH2COPr-n Me Me
H CH2CO2H Me Me
H CH2CO2Me Me Me
H CH2CO2Et Me Me
H CH2CO2Pr-n Me Me
R1 R2 R3 R4
H CH2OCH2CH＝CH2 Me Me
H CH2OCH2C≡CH Me Me
H CH＝CHCO2Me Me Me
H CH＝CHCO2Et Me Me
H CH＝CHCO2Pr-n Me Me
H CH＝CHCN Me Me
H Ph Me Me
H CH2Ph Me Me
H OPh Me Me
H SPh Me Me
H SO2Ph Me Me
H CONHMe Me Me
H CONHEt Me Me
H CONHPr-n Me Me
H CONHPr-i Me Me
H CONHBu-n Me Me
H CONHBu-sec Me Me
H CONHBu-t Me Me
H CON(Me)2 Me Me
H CON(Et)2 Me Me
H CON(Pr-n)2 Me Me
F Me Me Me
Cl Me Me Me
Br Me Me Me
I Me Me Me
CH＝CH2 Me Me Me
CH2CH＝CH2 Me Me Me
C≡CH Me Me Me
CH2C≡CH Me Me Me
CH2F Me Me Me
CHF2 Me Me Me
CN Me Me Me
NH2 Me Me Me
NHCOMe Me Me Me
CH2NH2 Me Me Me
CH2NHCOMe Me Me Me
CH2OCHF2 Me Me Me
CH2OCF3 Me Me Me
CF3 Me Me Me
NO2 Me Me Me
R1 R2 R3 R4
OMe Me Me Me
OEt Me Me Me
OPr-n Me Me Me
OBu-n Me Me Me
OPen-n Me Me Me
SMe Me Me Me
SEt Me Me Me
SPr-n Me Me Me
SBu-n Me Me Me
SPen-n Me Me Me
SO2Me Me Me Me
SO2Et Me Me Me
SO2Pr-n Me Me Me
COMe Me Me Me
COEt Me Me Me
COPr-n Me Me Me
CO2H Me Me Me
CO2Me Me Me Me
CO2Et Me Me Me
CO2Pr-n Me Me Me
CO2Bu-n Me Me Me
CO2Pen-n Me Me Me
CH2Cl Me Me Me
CH2Br Me Me Me
CH2I Me Me Me
CH2CF3 Me Me Me
CH2CN Me Me Me
CH2OH Me Me Me
CH2OMe Me Me Me
CH2OEt Me Me Me
CH2OPr-n Me Me Me
CH2SMe Me Me Me
CH2SEt Me Me Me
CH2SPr-n Me Me Me
CH2SO2Me Me Me Me
CH2SO2Et Me Me Me
CH2SO2Pr-n Me Me Me
CH2COMe Me Me Me
CH2COEt Me Me Me
CH2COPr-n Me Me Me
R1 R2 R3 R4
CH2CO2Me Me Me Me
CH2CO2Et Me Me Me
CH2CO2Pr-n Me Me Me
CH2OCH2CH＝CH2 Me Me Me
CH2OCH2C≡CH Me Me Me
CH＝CHCO2Me Me Me Me
CH＝CHCO2Et Me Me Me
CH＝CHCO2Pr-n Me Me Me
CH＝CHCN Me Me Me
Ph Me Me Me
CH2Ph Me Me Me
OPh Me Me Me
SPh Me Me Me
SO2Ph Me Me Me
CONHMe Me Me Me
CONHEt Me Me Me
CONHPr-n Me Me Me
CONHPr-i Me Me Me
CONHBu-n Me Me Me
CONHBu-sec Me Me Me
CONHBu-t Me Me Me
CON(Me)2 Me Me Me
CON(Et)2 Me Me Me
CON(Pr-n)2 Me Me Me
F Cl Me Me
Cl Cl Me Me
Br Cl Me Me
I Cl Me Me
CH＝CH2 Cl Me Me
CH2CH＝CH2 Cl Me Me
C≡CH Cl Me Me
CH2C≡CH Cl Me Me
CH2F Cl Me Me
CHF2 Cl Me Me
CN Cl Me Me
NH2 Cl Me Me
NHCOMe Cl Me Me
CH2NH2 Cl Me Me
CH2NHCOMe Cl Me Me
CH2OCHF2 Cl Me Me
R1 R2 R3 R4
CH2OCF3 Cl Me Me
CF3 Cl Me Me
NO2 Cl Me Me
OMe Cl Me Me
OEt Cl Me Me
OPr-n Cl Me Me
OBu-n Cl Me Me
OPen-n Cl Me Me
SMe Cl Me Me
SEt Cl Me Me
SPr-n Cl Me Me
SBu-n Cl Me Me
SPen-n Cl Me Me
SO2Me Cl Me Me
SO2Et Cl Me Me
SO2Pr-n Cl Me Me
COMe Cl Me Me
COEt Cl Me Me
COPr-n Cl Me Me
CO2H Cl Me Me
CO2Me Cl Me Me
CO2Et Cl Me Me
CO2Pr-n Cl Me Me
CO2Bu-n Cl Me Me
CO2Pen-n Cl Me Me
CH2Cl Cl Me Me
CH2Br Cl Me Me
CH2I Cl Me Me
CH2CF3 Cl Me Me
CH2CN Cl Me Me
CH2OH Cl Me Me
CH2OMe Cl Me Me
CH2OEt Cl Me Me
CH2OPr-n Cl Me Me
CH2SMe Cl Me Me
CH2SEt Cl Me Me
CH2SPr-n Cl Me Me
CH2SO2Me Cl Me Me
CH2SO2Et Cl Me Me
CH2SO2Pr-n Cl Me Me
R1 R2 R3 R4
CH2COMe Cl Me Me
CH2COEt Cl Me Me
CH2COPr-n Cl Me Me
CH2CO2H Cl Me Me
CH2CO2Me Cl Me Me
CH2CO2Et Cl Me Me
CH2CO2Pr-n Cl Me Me
CH2OCH2CH＝CH2 Cl Me Me
CH2OCH2C≡CH Cl Me Me
CH＝CHCO2Me Cl Me Me
CH＝CHCO2Et Cl Me Me
CH＝CHCO2Pr-n Cl Me Me
CH＝CHCN Cl Me Me
Ph Cl Me Me
CH2Ph Cl Me Me
OPh Cl Me Me
SPh Cl Me Me
SO2Ph Cl Me Me
CONHMe Cl Me Me
CONHEt Cl Me Me
CONHPr-n Cl Me Me
CONHPr-i Cl Me Me
CONHBu-n Cl Me Me
CONHBu-sec Cl Me Me
CONHBu-t Cl Me Me
CON(Me)2 Cl Me Me
CON(Et)2 Cl Me Me
CON(Pr-n)2 Cl Me Me
H H Me Et
F H Me Et
Cl H Me Et
I H Me Et
CH＝CH2 H Me Et
CH2CH＝CH2 H Me Et
C≡CH H Me Et
CH2C≡CH H Me Et
CH2F H Me Et
CHF2 H Me Et
CN H Me Et
R1 R2 R3 R4
NH2 H Me Et
NHCOMe H Me Et
CH2NH2 H Me Et
CH2NHCOMe H Me Et
CH2OCHF2 H Me Et
CH2OCF3 H Me Et
CF3 H Me Et
NO2 H Me Et
OMe H Me Et
OEt H Me Et
OPr-n H Me Et
OBu-n H Me Et
OPen-n H Me Et
SMe H Me Et
SEt H Me Et
SPr-n H Me Et
SBu-n H Me Et
SPen-n H Me Et
SO2Me H Me Et
SO2Et H Me Et
SO2Pr-n H Me Et
COMe H Me Et
COEt H Me Et
COPr-n H Me Et
CO2H H Me Et
CO2Me H Me Et
CO2Et H Me Et
CO2Pr-n H Me Et
CO2Bu-n H Me Et
CO2Pen-n H Me Et
CH2Cl H Me Et
CH2Br H Me Et
CH2I H Me Et
CH2CF3 H Me Et
CH2CN H Me Et
CH2OH H Me Et
CH2OMe H Me Et
CH2OEt H Me Et
CH2OPr-n H Me Et
CH2SMe H Me Et
R1 R2 R3 R4
CH2SEt H Me Et
CH2SPr-n H Me Et
CH2SO2Me H Me Et
CH2SO2Et H Me Et
CH2SO2Pr-n H Me Et
CH2COMe H Me Et
CH2COEt H Me Et
CH2COPr-n H Me Et
CH2CO2H H Me Et
CH2CO2Me H Me Et
CH2CO2Et H Me Et
CH2CO2Pr-n H Me Et
CH2OCH2CH＝CH2 H Me Et
CH2OCH2C≡CH H Me Et
CH＝CHCO2Me H Me Et
CH＝CHCO2Et H Me Et
CH＝CHCO2Pr-n H Me Et
CH＝CHCN H Me Et
Ph H Me Et
CH2Ph H Me Et
OPh H Me Et
SPh H Me Et
SO2Ph H Me Et
CONHMe H Me Et
CONHEt H Me Et
CONHPr-n H Me Et
CONHPr-i H Me Et
CONHBu-n H Me Et
CONHBu-sec H Me Et
CONHBu-t H Me Et
CON(Me)2 H Me Et
CON(Et)2 H Me Et
CON(Pr-n)2 H Me Et
H H Me Pr-n
F H Me Pr-n
Cl H Me Pr-n
Br H Me Pr-n
I H Me Pr-n
CH＝CH2 H Me Pr-n
CH2CH＝CH2 H Me Pr-n
R1 R2 R3 R4
C≡CH H Me Pr-n
CH2C≡CH H Me Pr-n
CH2F H Me Pr-n
CHF2 H Me Pr-n
CN H Me Pr-n
NH2 H Me Pr-n
NHCOMe H Me Pr-n
CH2NH2 H Me Pr-n
CH2NHCOMe H Me Pr-n
CH2OCHF2 H Me Pr-n
CH2OCF3 H Me Pr-n
CF3 H Me Pr-n
NO2 H Me Pr-n
OMe H Me Pr-n
OEt H Me Pr-n
OPr-n H Me Pr-n
OBu-n H Me Pr-n
OPen-n H Me Pr-n
SMe H Me Pr-n
SEt H Me Pr-n
SPr-n H Me Pr-n
SBu-n H Me Pr-n
SPen-n H Me Pr-n
SO2Me H Me Pr-n
SO2Et H Me Pr-n
SO2Pr-n H Me Pr-n
COMe H Me Pr-n
COEt H Me Pr-n
COPr-n H Me Pr-n
CO2H H Me Pr-n
CO2Me H Me Pr-n
CO2Et H Me Pr-n
CO2Pr-n H Me Pr-n
CO2Bu-n H Me Pr-n
CO2Pen-n H Me Pr-n
CH2Cl H Me Pr-n
CH2Br H Me Pr-n
CH2I H Me Pr-n
CH2CF3 H Me Pr-n
CH2CN H Me Pr-n
R1 R2 R3 R4
CH2OH H Me Pr-n
CH2OMe H Me Pr-n
CH2OEt H Me Pr-n
CH2OPr-n H Me Pr-n
CH2SMe H Me Pr-n
CH2SEt H Me Pr-n
CH2SPr-n H Me Pr-n
CH2SO2Me H Me Pr-n
CH2SO2Et H Me Pr-n
CH2SO2Pr-n H Me Pr-n
CH2COMe H Me Pr-n
CH2COEt H Me Pr-n
CH2COPr-n H Me Pr-n
CH2CO2H H Me Pr-n
CH2CO2Me H Me Pr-n
CH2CO2Et H Me Pr-n
CH2CO2Pr-n H Me Pr-n
CH2OCH2CH＝CH2 H Me Pr-n
CH2OCH2C≡CH H Me Pr-n
CH＝CHCO2Me H Me Pr-n
CH＝CHCO2Et H Me Pr-n
CH＝CHCO2Pr-n H Me Pr-n
CH＝CHCN H Me Pr-n
Ph H Me Pr-n
CH2Ph H Me Pr-n
OPh H Me Pr-n
SPh H Me Pr-n
SO2Ph H Me Pr-n
CONHMe H Me Pr-n
CONHEt H Me Pr-n
CONHPr-n H Me Pr-n
CONHPr-i H Me Pr-n
CONHBu-n H Me Pr-n
CONHBu-sec H Me Pr-n
CONHBu-t H Me Pr-n
CON(Me)2 H Me Pr-n
CON(Et)2 H Me Pr-n
CON(Pr-n)2 H Me Pr-n
H H Me Pr-i
F H Me Pr-i
R1 R2 R3 R4
Cl H Me Pr-i
Br H Me Pr-i
I H Me Pr-i
CH＝CH2 H Me Pr-i
CH2CH＝CH2 H Me Pr-i
C≡CH H Me Pr-i
CH2C≡CH H Me Pr-i
CH2F H Me Pr-i
CHF2 H Me Pr-i
CN H Me Pr-i
NH2 H Me Pr-i
NHCOMe H Me Pr-i
CH2NH2 H Me Pr-i
CH2NHCOMe H Me Pr-i
CH2OCHF2 H Me Pr-i
CH2OCF3 H Me Pr-i
CF3 H Me Pr-i
NO2 H Me Pr-i
OMe H Me Pr-i
OEt H Me Pr-i
OPr-n H Me Pr-i
OBu-n H Me Pr-i
OPen-n H Me Pr-i
SMe H Me Pr-i
SEt H Me Pr-i
SPr-n H Me Pr-i
SBu-n H Me Pr-i
SPen-n H Me Pr-i
SO2Me H Me Pr-i
SO2Et H Me Pr-i
SO2Pr-n H Me Pr-i
COMe H Me Pr-i
COEt H Me Pr-i
COPr-n H Me Pr-i
CO2H H Me Pr-i
CO2Me H Me Pr-i
CO2Et H Me Pr-i
CO2Pr-n H Me Pr-i
CO2Bu-n H Me Pr-i
CO2Pen-n H Me Pr-i
R1 R2 R3 R4
CH2Cl H Me Pr-i
CH2Br H Me Pr-i
CH2I H Me Pr-i
CH2CF3 H Me Pr-i
CH2CN H Me Pr-i
CH2OH H Me Pr-i
CH2OMe H Me Pr-i
CH2OEt H Me Pr-i
CH2OPr-n H Me Pr-i
CH2SMe H Me Pr-i
CH2SEt H Me Pr-i
CH2SPr-n H Me Pr-i
CH2SO2Me H Me Pr-i
CH2SO2Et H Me Pr-i
CH2SO2Pr-n H Me Pr-i
CH2COMe H Me Pr-i
CH2COEt H Me Pr-i
CH2COPr-n H Me Pr-i
CH2CO2H H Me Pr-i
CH2CO2Me H Me Pr-i
CH2CO2Et H Me Pr-i
CH2CO2Pr-n H Me Pr-i
CH2OCH2CH＝CH2 H Me Pr-i
CH2OCH2C≡CH H Me Pr-i
CH＝CHCO2Me H Me Pr-i
CH＝CHCO2Et H Me Pr-i
CH＝CHCO2Pr-n H Me Pr-i
CH＝CHCN H Me Pr-i
Ph H Me Pr-i
CH2Ph H Me Pr-i
OPh H Me Pr-i
SPh H Me Pr-i
SO2Ph H Me Pr-i
CONHMe H Me Pr-i
CONHEt H Me Pr-i
CONHPr-n H Me Pr-i
CONHPr-i H Me Pr-i
CONHBu-n H Me Pr-i
CONHBu-sec H Me Pr-i
CONHBu-t H Me Pr-i
R1 R2 R3 R4
CON(Me)2 H Me Pr-i
CON(Et)2 H Me Pr-i
CON(Pr-n)2 H Me Pr-i
H H Et Et
F H Et Et
Cl H Et Et
Br H Et Et
I H Et Et
CH＝CH2 H Et Et
CH2CH＝CH2 H Et Et
C≡CH H Et Et
CH2C≡CH H Et Et
CH2F H Et Et
CHF2 H Et Et
CN H Et Et
NH2 H Et Et
NHCOMe H Et Et
CH2NH2 H Et Et
CH2NHCOMe H Et Et
CH2OCHF2 H Et Et
CH2OCF3 H Et Et
CF3 H Et Et
NO2 H Et Et
OMe H Et Et
OEt H Et Et
OPr-n H Et Et
OBu-n H Et Et
OPen-n H Et Et
SMe H Et Et
SEt H Et Et
SPr-n H Et Et
SBu-n H Et Et
SPen-n H Et Et
SO2Me H Et Et
SO2Et H Et Et
SO2Pr-n H Et Et
COMe H Et Et
COEt H Et Et
COPr-n H Et Et
CO2H H Et Et
R1 R2 R3 R4
CO2Me H Et Et
CO2Et H Et Et
CO2Pr-n H Et Et
CO2Bu-n H Et Et
CO2Pen-n H Et Et
CH2Cl H Et Et
CH2Br H Et Et
CH2I H Et Et
CH2CF3 H Et Et
CH2CN H Et Et
CH2OH H Et Et
CH2OMe H Et Et
CH2OEt H Et Et
CH2OPr-n H Et Et
CH2SMe H Et Et
CH2SEt H Et Et
CH2SPr-n H Et Et
CH2SO2Me H Et Et
CH2SO2Et H Et Et
CH2SO2Pr-n H Et Et
CH2COMe H Et Et
CH2COEt H Et Et
CH2COPr-n H Et Et
CH2CO2H H Et Et
CH2CO2Me H Et Et
CH2CO2Et H Et Et
CH2CO2Pr-n H Et Et
CH2OCH2CH＝CH2 H Et Et
CH2OCH2C≡CH H Et Et
CH＝CHCO2Me H Et Et
CH＝CHCO2Et H Et Et
CH＝CHCO2Pr-n H Et Et
CH＝CHCN H Et Et
Ph H Et Et
CH2Ph H Et Et
OPh H Et Et
SPh H Et Et
SO2Ph H Et Et
CONHMe H Et Et
CONHEt H Et Et
R1 R2 R3 R4
CONHPr-n H Et Et
CONHPr-i H Et Et
CONHBu-n H Et Et
CONHBu-sec H Et Et
CONHBu-t H Et Et
CON(Me)2 H Et Et
CON(Et)2 H Et Et
CON(Pr-n)2 H Et Et
H H F H
H H Cl H
H H Br H
H H I H
H H CH＝CH2 H
H H CH2CH＝CH2 H
H H C≡CH H
H H CH2C≡CH H
H H CH2F H
H H CHF2 H
H H CN H
H H NH2 H
H H NHCOMe H
H H CH2NH2 H
H H CH2NHCOMe H
H H CH2OCHF2 H
H H CH2OCF3 H
H H CF3 H
H H NO2 H
H H OMe H
H H OEt H
H H OPr-n H
H H OBu-n H
R1 R2 R3 R4
H H OPen-n H
H H SMe H
H H SEt H
H H SPr-n H
H H SBu-n H
H H SPen-n H
H H SO2Me H
H H SO2Et H
H H SO2Pr-n H
H H COMe H
H H COEt H
H H COPr-n H
H H CO2H H
H H CO2Me H
H H CO2Et H
H H CO2Pr-n H
H H CO2Bu-n H
H H CO2Pen-n H
H H CH2Cl H
H H CH2Br H
H H CH2I H
H H CH2CF3 H
H H CH2CN H
H H CH2OH H
H H CH2OMe H
H H CH2OEt H
H H CH2OPr-n H
H H CH2SMe H
H H CH2SEt H
H H CH2SPr-n H
H H CH2SO2Me H
H H CH2SO2Et H
H H CH2SO2Pr-n H
H H CH2OSO2Me H
H H CH2COMe H
H H CH2COEt H
H H CH2SO2Pr-n H
H H CH2CO2H H
H H CH2COMe H
H H CH2CO2Et H
H H CH2CO2Pr-n H
R1 R2 R3 R4
H H CH2OCH2CH＝CH2 H
H H CH2OCH2C≡CH H
H H CH＝CHCO2Me H
H H CH＝CHCO2Et H
H H CH＝CHCO2Pr-n H
H H CH＝CHCN H
H H Ph H
H H Ph-2-F H
H H Ph-3-F H
H H Ph-4-F H
H H Ph-2-Cl H
H H Ph-3-Cl H
H H Ph-4-Cl H
H H Ph-2-Br H
H H Ph-3-Br H
H H Ph-4-Br H
H H Ph-2-CF3 H
H H Ph-3-CF3 H
H H Ph-4-CF3 H
H H Ph-2-Me H
H H Ph-3-Me H
H H Ph-4-Me H
H H Ph-2-Et H
H H Ph-2-OMe H
H H Ph-3-OMe H
H H Ph-4-OMe H
H H Ph-2-OEt H
H H Ph-2-CO2Me H
H H Ph-2-CO2Et H
H H Ph-3-CO2Me H
H H Ph-4-CO2Me H
H H CH2Ph H
H H CH2Ph-2-F H
H H CH2Ph-3-F H
H H CH2Ph-4-F H
H H CH2Ph-2-Cl H
H H CH2Ph-3-Cl H
H H CH2Ph-4-Cl H
H H CH2Ph-2-Br H
H H CH2Ph-3-Br H
R1 R2 R3 R4
H H CH2Ph-4-Br H
H H CH2Ph-2-CF3 H
H H CH2Ph-3-CF3 H
H H CH2Ph-4-CF3 H
H H CH2Ph-2-Me H
H H CH2Ph-3-Me H
H H CH2Ph-4-Me H
H H CH2Ph-2-Et H
H H CH2Ph-2-OMe H
H H CH2Ph-3-OMe H
H H CH2Ph-4-OMe H
H H CH2Ph-2-OEt H
H H CH2Ph-2-CO2Me H
H H CH2Ph-2-CO2Et H
H H CH2Ph-3-CO2Me H
H H CH2Ph-4-CO2Me H
H H OPh H
H H OPh-2-Cl H
H H OPh-3-Cl H
H H OPh-4-Cl H
H H OPh-2-F H
H H OPh-3-F H
H H OPh-4-F H
H H OPh-2-CF3 H
H H OPh-3-CF3 H
H H OPh-4-CF3 H
H H OPh-2-Me H
H H OPh-3-Me H
H H OPh-4-Me H
H H OPh-2-Et H
H H OPh-2-OMe H
H H OPh-3-OMe H
H H OPh-4-OMe H
H H OPh-2-OEt H
H H OPh-2-CO2Me H
H H OPh-3-CO2Me H
H H OPh-4-CO2Me H
H H OPh-2-CO2Et H
H H SPh H
H H SPh-2-Cl H
R1 R2 R3 R4
H H SPh-3-Cl H
H H SPh-4-Cl H
H H SPh-2-F H
H H SPh-3-F H
H H SPh-4-F H
H H SPh-2-CF3 H
H H SPh-3-CF3 H
H H SPh-4-CF3 H
H H SPh-2-Me H
H H SPh-3-Me H
H H SPh-4-Me H
H H SPh-2-Et H
H H SPh-2-OMe H
H H SPh-3-OMe H
H H SPh-4-OMe H
H H SPh-2-OEt H
H H SPh-2-CO2Me H
H H SPh-3-CO2Me H
H H SPh-4-CO2Me H
H H SPh-2-CO2Et H
H H SO2Ph H
H H SO2Ph-2-Cl H
H H SO2Ph-3-Cl H
H H SO2Ph-4-Cl H
H H SO2Ph-2-F H
H H SO2Ph-3-F H
H H SO2Ph-4-F H
H H SO2Ph-2-CF3 H
H H SO2Ph-3-CF3 H
H H SO2Ph-4-CF3 H
H H SO2Ph-2-Me H
H H SO2Ph-3-Me H
H H SO2Ph-4-Me H
H H SO2Ph-2-Et H
H H SO2Ph-2-OMe H
H H SO2Ph-3-OMe H
H H SO2Ph-4-OMe H
H H SO2Ph-2-OEt H
H H SO2Ph-2-CO2Me H
H H SO2Ph-3-CO2Me H
R1 R2 R3 R4
H H SO2Ph-4-CO2Me H
H H SO2Ph-2-CO2Et H
H H CONHMe H
H H CONHEt H
H H CONHPr-n H
H H CONHPr-i H
H H CONHBu-n H
H H CONHBu-sec H
H H CONHBu-t H
H H CON(Me)2 H
H H CON(Et)2 H
H H CON(Pr-n)2 H
F H H H
Cl H H H
Br H H H
I H H H
CH＝CH2 H H H
CH2CH＝CH2 H H H
C≡CH H H H
CH2C≡CH H H H
CH2F H H H
CHF2 H H H
CN H H H
NH2 H H H
NHCOMe H H H
CH2NH2 H H H
CH2NHCOMe H H H
CH2OCHF2 H H H
CH2OCF3 H H H
CF3 H H H
NO2 H H H
OMe H H H
OEt H H H
OPr-n H H H
OBu-n H H H
OPen-n H H H
SMe H H H
SEt H H H
SPr-n H H H
SBu-n H H H
R1 R2 R3 R4
SPen-n H H H
SO2Me H H H
SO2Et H H H
SO2Pr-n H H H
COMe H H H
COEt H H H
COPr-n H H H
CO2H H H H
CO2Me H H H
CO2Et H H H
CO2Pr-n H H H
CO2Bu-n H H H
CO2Pen-n H H H
CH2Cl H H H
CH2Br H H H
CH2I H H H
CH2CF3 H H H
CH2CN H H H
CH2OH H H H
CH2OMe H H H
CH2OEt H H H
CH2OPr-n H H H
CH2SMe H H H
CH2SEt H H H
CH2SPr-n H H H
CH2SO2Me H H H
CH2SO2Et H H H
CH2SO2Pr-n H H H
CH2COMe H H H
CH2COEt H H H
CH2COPr-n H H H
CH2CO2H H H H
CH2CO2Me H H H
CH2CO2Et H H H
CH2CO2Pr-n H H H
CH2OCH2CH＝CH2 H H H
CH2OCH2C≡CH H H H
CH＝CHCO2Me H H H
CH＝CHCO2Et H H H
CH＝CHCO2Pr-n H H H
R1 R2 R3 R4
CH＝HCN H H H
Ph H H H
Ph-2-F H H H
Ph-3-F H H H
Ph-4-F H H H
Ph-2-Cl H H H
Ph-3-Cl H H H
Ph-4-Cl H H H
Ph-2-Br H H H
Ph-3-Br H H H
Ph-4-Br H H H
Ph-2-CF3 H H H
Ph-3-CF3 H H H
Ph-4-CF3 H H H
Ph-2-Me H H H
Ph-3-Me H H H
Ph-4-Me H H H
Ph-2-Et H H H
Ph-2-OMe H H H
Ph-3-OMe H H H
Ph-4-OMe H H H
Ph-2-OEt H H H
Ph-2-CO2Me H H H
Ph-2-CO2Et H H H
Ph-3-CO2Me H H H
Ph-4-CO2Me H H H
CH2Ph H H H
CH2Ph-2-F H H H
CH2Ph-3-F H H H
CH2Ph-4-F H H H
CH2Ph-2-Cl H H H
CH2Ph-3-Cl H H H
CH2Ph-4-Cl H H H
CH2Ph-2-Br H H H
CH2Ph-3-Br H H H
CH2Ph-4-Br H H H
CH2Ph-2-CF3 H H H
CH2Ph-3-CF3 H H H
CH2Ph-4-CF3 H H H
CH2Ph-2-Me H H H
R1 R2 R3 R4
CH2Ph-3-Me H H H
CH2Ph-4-Me H H H
CH2Ph-2-Et H H H
CH2Ph-2-OMe H H H
CH2Ph-3-OMe H H H
CH2Ph-4-OMe H H H
CH2Ph-2-OEt H H H
CH2Ph-2-CO2Me H H H
CH2Ph-2-CO2Et H H H
CH2Ph-3-CO2Me H H H
CH2Ph-4-CO2Me H H H
OPh H H H
OPh-2-Cl H H H
OPh-3-Cl H H H
OPh-4-Cl H H H
OPh-2-F H H H
OPh-3-F H H H
OPh-4-F H H H
OPh-2-CF3 H H H
OPh-3-CF3 H H H
OPh-4-CF3 H H H
OPh-2-Me H H H
OPh-3-Me H H H
OPh-4-Me H H H
OPh-2-Et H H H
OPh-2-OMe H H H
OPh-3-OMe H H H
OPh-4-OMe H H H
OPh-2-OEt H H H
OPh-2-CO2Me H H H
OPh-3-CO2Me H H H
OPh-4-CO2Me H H H
OPh-2-CO2Et H H H
SPh H H H
SPh-2-Cl H H H
SPh-3-Cl H H H
SPh-4-Cl H H H
SPh-2-F H H H
SPh-3-F H H H
SPh-4-F H H H
R1 R2 R3 R4
SPh-2-CF3 H H H
SPh-3-CF3 H H H
SPh-4-CF3 H H H
SPh-2-Me H H H
SPh-3-Me H H H
SPh-4-Me H H H
SPh-2-Et H H H
SPh-2-OMe H H H
SPh-3-OMe H H H
SPh-4-OMe H H H
SPh-2-OEt H H H
SPh-2-CO2Me H H H
SPh-3-CO2Me H H H
SPh-4-CO2Me H H H
SPh-2-CO2Et H H H
SO2Ph H H H
SO2Ph-2-Cl H H H
SO2Ph-3-Cl H H H
SO2Ph-4-Cl H H H
SO2Ph-2-F H H H
SO2Ph-3-F H H H
SO2Ph-4-F H H H
SO2Ph-2-CF3 H H H
SO2Ph-3-CF3 H H H
SO2Ph-4-CF3 H H H
SO2Ph-2-Me H H H
SO2Ph-3-Me H H H
SO2Ph-4-Me H H H
SO2Ph-2-Et H H H
SO2Ph-2-OMe H H H
SO2Ph-3-OMe H H H
SO2Ph-4-OMe H H H
SO2Ph-2-OEt H H H
SO2Ph-2-CO2Me H H H
SO2Ph-3-CO2Me H H H
SO2Ph-4-CO2Me H H H
SO2Ph-2-CO2Et H H H
CONHMe H H H
CONHEt H H H
CONHPr-n H H H
R1 R2 R3 R4
CONHPr-i H H H
CONHBu-n H H H
CONHBu-sec H H H
CONHBu-t H H H
CON(Me)2 H H H
CON(Et)2 H H H
CON(Pr-n)2 H H H
R1 R2 R3 R4
H F H H
H Cl H H
H Br H H
H I H H
H CH＝CH2 H H
H CH2CH＝CH2 H H
H C≡CH H H
H CH2C≡CH H H
H CH2F H H
H CHF2 H H
H CN H H
H NH2 H H
H NHCOMe H H
H CH2NH2 H H
H CH2NHCOMe H H
H CH2OCHF2 H H
H CH2OCF3 H H
H CF3 H H
H NO2 H H
H OMe H H
H OEt H H
H OPr-n H H
H OBu-n H H
H OPen-n H H
H SMe H H
H SEt H H
H SPr-n H H
H SBu-n H H
H SPen-n H H
H SO2Me H H
H SO2Et H H
H SO2Pr-n H H
H COMe H H
H COEt H H
H COPr-n H H
H CO2H H H
H CO2Me H H
H CO2Et H H
H CO2Pr-n H H
H CO2Bu-n H H
R1 R2 R3 R4
H CO2Pen-n H H
H CH2Cl H H
H CH2Br H H
H CH2I H H
H CH2CF3 H H
H CH2CN H H
H CH2OH H H
H CH2OMe H H
H CH2OEt H H
H CH2OPr-n H H
H CH2SMe H H
H CH2SEt H H
H CH2SPr-n H H
H CH2SO2Me H H
H CH2SO2Et H H
H CH2SO2Pr-n H H
H CH2COMe H H
H CH2COEt H H
H CH2COPr-n H H
H CH2CO2H H H
H CH2CO2Me H H
H CH2CO2Et H H
H CH2CO2Pr-n H H
H CH2OCH2CH＝CH2 H H
H CH2OCH2C≡CH H H
H CH＝CHCO2Me H H
H CH＝CHCO2Et H H
H CH＝CHCO2Pr-n H H
H CH＝CHCN H H
H Ph H H
H Ph-2-P H H
H Ph-3-F H H
H Ph-4-F H H
H Ph-2-Cl H H
H Ph-3-Cl H H
H Ph-4-Cl H H
H Ph-2-Br H H
H Ph-3-Br H H
H Ph-4-Br H H
H Ph-2-CF3 H H
R1 R2 R3 R4
H Ph-3-CF3 H H
H Ph-4-CF3 H H
H Ph-2-Me H H
H Ph-3-Me H H
H Ph-4-Me H H
H Ph-2-Et H H
H Ph-2-OMe H H
H Ph-3-OMe H H
H Ph-4-OMe H H
H Ph-2-OEt H H
H Ph-2-CO2Me H H
H Ph-2-CO2Et H H
H Ph-3-CO2Me H H
H Ph-4-CO2Me H H
H CH2Ph H H
H CH2Ph-2-F H H
H CH2Ph-3-F H H
H CH2Ph-4-F H H
H CH2Ph-2-Cl H H
H CH2Ph-3-Cl H H
H CH2Ph-4-Cl H H
H CH2Ph-2-Br H H
H CH2Ph-3-Br H H
H CH2Ph-4-Br H H
H CH2Ph-2-CF3 H H
H CH2Ph-3-CF3 H H
H CH2Ph-4-CF3 H H
H CH2Ph-2-Me H H
H CH2Ph-3-Me H H
H CH2Ph-4-Me H H
H CH2Ph-2-Et H H
H CH2Ph-2-OMe H H
H CH2Ph-3-OMe H H
H CH2Ph-4-OMe H H
H CH2Ph-2-OEt H H
H CH2Ph-2-CO2Me H H
H CH2Ph-2-CO2Et H H
H CH2Ph-3-CO2Me H H
H CH2Ph-4-CO2Me H H
H OPh H H
R1 R2 R3 R4
H OPh-2-Cl H H
H OPh-3-Cl H H
H OPh-4-Cl H H
H OPh-2-F H H
H OPh-3-F H H
H OPh-4-F H H
H OPh-2-CF3 H H
H OPh-3-CF3 H H
H OPh-4-CF3 H H
H OPh-2-Me H H
H OPh-3-Me H H
H OPh-4-Me H H
H OPh-2-Et H H
H OPh-2-OMe H H
H OPh-3-OMe H H
H OPh-4-OMe H H
H OPh-2-OEt H H
H OPh-2-CO2Me H H
H OPh-3-CO2Me H H
H OPh-4-CO2Me H H
H OPh-2-CO2Et H H
H SPh H H
H SPh-2-Cl H H
H SPh-3-Cl H H
H SPh-4-Cl H H
H SPh-2-F H H
H SPh-3-F H H
H SPh-4-F H H
H SPh-2-CF3 H H
H SPh-3-CF3 H H
H SPh-4-CF3 H H
H SPh-2-Me H H
H SPh-3-Me H H
H SPh-4-Me H H
H SPh-2-Et H H
H SPh-2-OMe H H
H SPh-3-OMe H H
H SPh-4-OMe H H
H SPh-2-OEt H H
H SPh-2-CO2Me H H
R1 R2 R3 R4
H SPh-3-CO2Me H H
H SPh-4-CO2Me H H
H SPh-2-CO2Et H H
H SO2Ph H H
H SO2Ph-2-Cl H H
H SO2Ph-3-Cl H H
H SO2Ph-4-Cl H H
H SO2Ph-2-F H H
H SO2Ph-3-F H H
H SO2Ph-4-F H H
H SO2Ph-2-CF3 H H
H SO2Ph-3-CF3 H H
H SO2Ph-4-CF3 H H
H SO2Ph-2-Me H H
H SO2Ph-3-Me H H
H SO2Ph-4-Me H H
H SO2Ph-2-Et H H
H SO2Ph-2-OMe H H
H SO2Ph-3-OMe H H
H SO2Ph-4-OMe H H
H SO2Ph-2-OEt H H
H CH2Ph-2-CO2Me H H
H CH2Ph-3-CO2Me H H
H CH2Ph-4-CO2Me H H
H CH2Ph-2-CO2Et H H
H CONHMe H H
H CONHEt H H
H CONHPr-n H H
H CONHPr-i H H
H CONHBu-n H H
H CONHBu-sec H H
H CONHBu-t H H
H CON(Me)2 H H
H CON(Et)2 H H
H CON(Pr-n)2 H H
Me Me H H
Me H Me H
Me Et H H
Me H Et H
Me Pr-n H H
R1 R2 R3 R4
Me H Pr-n H
Me Pr-i H H
Me H Pr-i H
Me Bu-n H H
Me H Bu-n H
Et Me H H
Et H Me H
Et Et H H
Et H Et H
Et Pr-n H H
Et H Pr-n H
Et Pr-i H H
Et H Pr-i H
Et Bu-n H H
Et H Bu-n H
Pr-n Me H H
Pr-n H Me H
Pr-n Et H H
Pr-n H Et H
Pr-n Pr-n H H
Pr-n H Pr-n H
Pr-n Pr-i H H
Pr-n H Pr-i H
Pr-n Bu-n H H
Pr-n H Bu-n H
Pr-i Me H H
Pr-i H Me H
Pr-i Et H H
Pr-i H Et H
Pr-i Pr-n H H
Pr-i H Pr-n H
Pr-i Pr-i H H
Pr-i H Pr-i H
Pr-i Bu-n H H
Pr-i H Bu-n H
Bu-n Me H H
Bu-n H Me H
Bu-n Et H H
Bu-n H Et H
Bu-n Pr-n H H
R1 R2 R3 R4
Bu-n H Pr-n H
Bu-n Pr-i H H
Bu-n H Pr-i H
Bu-n Bu-n H H
Bu-n H Bu-n H
H Me Me H
H Me Et H
H Me Pr-n H
H Me Pr-i H
H Me Bu-n H
H Et Me H
H Et Et H
H Et Pr-n H
H Et Pr-i H
H Et Bu-n H
H Pr-n Me H
H Pr-n Et H
H Pr-n Pr-n H
H Pr-n Pr-i H
H Pr-n Bu-n H
H Pr-i Me H
H Pr-i Et H
H Pr-i Pr-n H
H Pr-i Pr-i H
H Pr-i Bu-n H
H Bu-n Me H
H Bu-n Et H
H Bu-n Pr-n H
H Bu-n Pr-i H
H Bu-n Bu-n H
Me Me Me H
Me Me Et H
Me Me Pr-n H
Me Me Pr-i H
Me Me Bu-n H
Me Et Me H
Me Et Et H
Me Et Pr-n H
Me Et Pr-i H
Me Et Bu-n H
R1 R2 R3 R4
Me Pr-n Me H
Me Pr-n Et H
Me Pr-n Pr-n H
Me Pr-n Pr-i H
Me Pr-n Bu-n H
Me Pr-i Me H
Me Pr-i Et H
Me Pr-i Pr-n H
Me Pr-i Pr-i H
Me Pr-i Bu-n H
Me Bu-n Me H
Me Bu-n Et H
Me Bu-n Pr-n H
Me Bu-n Pr-i H
Me Bu-n Bu-n H
Et Me Me H
Et Me Et H
Et Me Pr-n H
Et Me Pr-i H
Et Me Bu-n H
Et Et Me H
Et Et Et H
Et Et Pr-n H
Et Et Pr-i H
Et Et Bu-n H
Et Pr-n Me H
Et Pr-n Et H
Et Pr-n Pr-n H
Et Pr-n Pr-i H
Et Pr-n Bun H
Et Pr-i Me H
Et Pr-i Et H
Et Pr-i Pr-n H
Et Pr-i Pr-i H
Et Pr-i Bu-n H
Et Bu-n Me H
Et Bu-n Et H
Et Bu-n Pr-n H
Et Bu-n Pr-i H
Et Bu-n Bu-n H
R1 R2 R3 R4
Pr-n Me Me H
Pr-n Me Et H
Pr-n Me Pr-n H
Pr-n Me Pr-i H
Pr-n Me Bu-n H
Pr-n Et Me H
Pr-n Et Et H
Pr-n Et Pr-n H
Pr-n Et Pr-i H
Pr-n Et Bu-n H
Pr-n Pr-n Me H
Pr-n Pr-n Et H
Pr-n Pr-n Pr-n H
Pr-n Pr-n Pr-i H
Pr-n Pr-n Bu-n H
Pr-n Pr-i Me H
Pr-n Pr-i Et H
Pr-n Pr-i Pr-n H
Pr-n Pr-i Pr-i H
Pr-n Pr-i Bu-n H
Pr-n Bu-n Me H
Pr-n Bu-n Et H
Pr-n Bu-n Pr-n H
Pr-n Bu-n Pr-i H
Pr-n Bu-n Bu-n H
Pr-i Me Me H
Pr-i Me Et H
Pr-i Me Pr-n H
Pr-i Me Pr-i H
Pr-i Me Bu-n H
Pr-i Et Me H
Pr-i Et Et H
Pr-i Et Pr-n H
Pr-i Et Pr-i H
Pr-i Et Bu-n H
Pr-i Pr-n Me H
Pr-i Pr-n Et H
Pr-i Pr-n Pr-n H
Pr-i Pr-n Pr-i H
Pr-i Pr-n Bu-n H
R1 R2 R3 R4
Pr-i Pr-i Me H
Pr-i Pr-i Et H
Pr-i Pr-i Pr-n H
Pr-i Pr-i Pr-i H
Pr-i Pr-i Bu-n H
Pr-i Bu-n Me H
Pr-i Bu-n Et H
Pr-i Bu-n Pr-n H
Pr-i Bu-n Pr-i H
Pr-i Bu-n Bu-n H
Bu-n Me Me H
Bu-n Me Et H
Bu-n Me Pr-n H
Bu-n Me Pr-i H
Bu-n Me Bu-n H
Bu-n Et Me H
Bu-n Et Et H
Bu-n Et Pr-n H
Bu-n Et Pr-i H
Bu-n Et Bu-n H
Bu-n Pr-n Me H
Bu-n Pr-n Et H
Bu-n Pr-n Pr-n H
Bu-n Pr-n Pr-i H
Bu-n Pr-n Bu-n H
Bu-n Pr-i Me H
Bu-n Pr-i Et H
Bu-n Pr-i Pr-n H
Bu-n Pr-i Pr-i H
Bu-n Pr-i Bu-n H
Bu-n Bu-n Me H
Bu-n Bu-n Et H
Bu-n Bu-n Pr-n H
Bu-n Bu-n Pr-i H
Bu-n Bu-n Bu-n H
F H Me H
Cl H Me H
Br H Me H
I H Me H
CH＝CH2 H Me H
R1 R2 R3 R4
CH2CH＝CH2 H Me H
C≡CH H Me H
CH2C≡CH H Me H
CH2F H Me H
CHF2 H Me H
CN H Me H
NH2 H Me H
NHCOMe H Me H
CH2NH2 H Me H
CH2NHCOMe H Me H
CH2OCHF2 H Me H
CH2OCF3 H Me H
CF3 H Me H
NO2 H Me H
OMe H Me H
OEt H Me H
OPr-n H Me H
OBu-n H Me H
OPen-n H Me H
SMe H Me H
SEt H Me H
SPr-n H Me H
SBu-n H Me H
SPen-n H Me H
SO2Me H Me H
SO2Et H Me H
SO2Pr-n H Me H
COMe H Me H
COEt H Me H
COPr-n H Me H
CO2H H Me H
CO2Me H Me H
CO2Et H Me H
CO2Pr-n H Me H
CO2Bu-n H Me H
CO2Pen-n H Me H
CH2Cl H Me H
CH2Br H Me H
CH2I H Me H
CH2CF3 H Me H
R1 R2 R3 R4
CH2CN H Me H
CH2OH H Me H
CH2OMe H Me H
CH2OEt H Me H
CH2OPr-n H Me H
CH2SMe H Me H
CH2SEt H Me H
CH2SPr-n H Me H
CH2SO2Me H Me H
CH2SO2Et H Me H
CH2SO2Pr-n H Me H
CH2COMe H Me H
CH2COEt H Me H
CH2COPr-n H Me H
CH2CO2H H Me H
CH2CO2Me H Me H
CH2CO2Et H Me H
CH2CO2Pr-n H Me H
CH2OCH2CH＝CH2 H Me H
CH2OCH2C≡CH H Me H
CH＝CHCO2Me H Me H
CH＝CHCO2Et H Me H
CH＝CHCO2Pr-n H Me H
CH＝CHCN H Me H
Ph H Me H
Ph-2-F H Me H
Ph-3-F H Me H
Ph-4-F H Me H
Ph-2-Cl H Me H
Ph-3-Cl H Me H
Ph-4-Cl H Me H
Ph-2-Br H Me H
Ph-3-Br H Me H
Ph-4-Br H Me H
Ph-2-CF3 H Me H
Ph-3-CF3 H Me H
Ph-4-CF3 H Me H
Ph-2-Me H Me H
Ph-3-Me H Me H
Ph-4-Me H Me H
R1 R2 R3 R4
Ph-2-Et H Me H
Ph-2-OMe H Me H
Ph-3-OMe H Me H
Ph-4-OMe H Me H
Ph-2-OEt H Me H
Ph-2-CO2Me H Me H
Ph-2-CO2Et H Me H
Ph-3-CO2Me H Me H
Ph-4-CO2Me H Me H
CH2Ph H Me H
CH2Ph-2-F H Me H
CH2Ph-3-F H Me H
CH2Ph-4-F H Me H
CH2Ph-2-Cl H Me H
CH2Ph-3-Cl H Me H
CH2Ph-4-Cl H Me H
CH2Ph-2-Br H Me H
CH2Ph-3-Br H Me H
CH2Ph-4-Br H Me H
CH2Ph-2-CF3 H Me H
CH2Ph-3-CF3 H Me H
CH2Ph-4-CF3 H Me H
CH2Ph-2-Me H Me H
CH2Ph-3-Me H Me H
CH2Ph-4-Me H Me H
CH2Ph-2-Et H Me H
CH2Ph-2-OMe H Me H
CH2Ph-3-OMe H Me H
CH2Ph-4-OMe H Me H
CH2Ph-2-OEt H Me H
CH2Ph-2-CO2Me H Me H
CH2Ph-2-CO2Et H Me H
CH2Ph-3-CO2Me H Me H
CH2Ph-4-CO2Me H Me H
OPh H Me H
OPh-2-Cl H Me H
OPh-3-Cl H Me H
OPh-4-Cl H Me H
OPh-2-F H Me H
OPh-3-F H Me H
R1 R2 R3 R4
OPh-4-F H Me H
OPh-2-CF3 H Me H
OPh-3-CF3 H Me H
OPh-4-CF3 H Me H
OPh-2-Me H Me H
OPh-3-Me H Me H
OPh-4-Me H Me H
OPh-2-Et H Me H
OPh-2-OMe H Me H
OPh-3-OMe H Me H
OPh-4-OMe H Me H
OPh-2-OEt H Me H
OPh-2-CO2Me H Me H
OPh-3-CO2Me H Me H
OPh-4-CO2Me H Me H
OPh-2-CO2Et H Me H
SPh H Me H
SPh-2-Cl H Me H
SPh-3-Cl H Me H
SPh-4-Cl H Me H
SPh-2-F H Me H
SPh-3-F H Me H
SPh-4-F H Me H
SPh-2-CF3 H Me H
SPh-3-CF3 H Me H
SPh-4-CF3 H Me H
SPh-2-Me H Me H
SPh-3-Me H Me H
SPh-4-Me H Me H
SPh-2-Et H Me H
SPh-2-OMe H Me H
SPh-3-OMe H Me H
SPh-4-OMe H Me H
SPh-2-OEt H Me H
SPh-2-CO2Me H Me H
SPh-3CO2Me H Me H
SPh-4-CO2Me H Me H
SPh-2-CO2Et H Me H
SO2Ph H Me H
SO2Ph-2-Cl H Me H
R1 R2 R3 R4
SO2Ph-3-Cl H Me H
SO2Ph-4-Cl H Me H
SO2Ph-2-F H Me H
SO2Ph-3-F H Me H
SO2Ph-4-F H Me H
SO2Ph-2-CF3 H Me H
SO2Ph-3-CF3 H Me H
SO2Ph-4-CF3 H Me H
SO2Ph-2-Me H Me H
SO2Ph-3-Me H Me H
SO2Ph-4-Me H Me H
SO2Ph-2-Et H Me H
SO2Ph-2-OMe H Me H
SO2Ph-3-OMe H Me H
SO2Ph-4-OMe H Me H
SO2Ph-2-OEt H Me H
CH2Ph-2-CO2Me H Me H
CH2Ph-3-CO2Me H Me H
CH2Ph-4-CO2Me H Me H
CH2Ph-2-CO2Et H Me H
CONHMe H Me H
CONHEt H Me H
CONHPr-n H Me H
CONHPr-i H Me H
CONHBu-n H Me H
CONHBu-sec H Me H
CONHBu-t H Me H
CON(Me)2 H Me H
CON(Et)2 H Me H
CON(Pr-n)2 H Me H
F H Et H
Cl H Et H
Br H Et H
I H Et H
CH＝CH2 H Et H
CH2CH＝CH2 H Et H
C≡CH H Et H
CH2C≡CH H Et H
CH2F H Et H
CHF2 H Et H
R1 R2 R3 R4
CN H Et H
NH2 H Et H
NHCOMe H Et H
CH2NH2 H Et H
CH2NHCOMe H Et H
CH2OCHF2 H Et H
CH2OCF3 H Et H
CF3 H Et H
NO2 H Et H
OMe H Et H
OEt H Et H
OPr-n H Et H
OBu-n H Et H
OPen-n H Et H
SMe H Et H
SEt H Et H
SPr-n H Et H
SBu-n H Et H
SPen-n H Et H
SO2Me H Et H
SO2Et H Et H
SO2Pr-n H Et H
COMe H Et H
COEt H Et H
COPr-n H Et H
CO2H H Et H
CO2Me H Et H
CO2Et H Et H
CO2Pr-n H Et H
CO2Bu-n H Et H
CO2Pen-n H Et H
CH2Cl H Et H
CH2Br H Et H
CH2I H Et H
CH2CF3 H Et H
CH2CN H Et H
CH2OH H Et H
CH2OMe H Et H
CH2OEt H Et H
CH2OPr-n H Et H
R1 R2 R3 R4
CH2SMe H Et H
CH2SEt H Et H
CH2SPr-n H Et H
CH2SO2Me H Et H
CH2SO2Et H Et H
CH2SO2Pr-n H Et H
CH2COMe H Et H
CH2COEt H Et H
CH2COPr-n H Et H
CH2CO2H H Et H
CH2CO2Me H Et H
CH2CO2Et H Et H
CH2CO2Pr-n H Et H
CH2OCH2CH＝CH2 H Et H
CH2OCH2C≡CH H Et H
CH＝CHCO2Me H Et H
CH＝CHCO2Et H Et H
CH＝CHCO2Pr-n H Et H
CH＝CHCN H Et H
Ph H Et H
CH2Ph H Et H
OPh H Et H
SPh H Et H
SO2Ph H Et H
CONHMe H Et H
CONHEt H Et H
CONHPr-n H Et H
CONHPr-i H Et H
CONHBu-n H Et H
CONHBu-sec H Et H
CONHBu-t H Et H
CON(Me)2 H Et H
CON(Et)2 H Et H
CON(Pr-n)2 H Et H
F Me H H
Cl Me H H
Br Me H H
I Me H H
CH＝CH2 Me H H
CH2CH＝CH2 Me H H
R1 R2 R3 R4
C≡CH Me H H
CH2C≡CH Me H H
CH2F Me H H
CHF2 Me H H
CN Me H H
NH2 Me H H
NHCOMe Me H H
CH2NH2 Me H H
CH2NHCOMe Me H H
CH2OCHF2 Me H H
CH2OCF3 Me H H
CF3 Me H H
NO2 Me H H
OMe Me H H
OEt Me H H
OPr-n Me H H
OBu-n Me H H
OPen-n Me H H
SMe Me H H
SEt Me H H
SPr-n Me H H
SBu-n Me H H
SPen-n Me H H
SO2Me Me H H
SO2Et Me H H
SO2Pr-n Me H H
COMe Me H H
H Me H H
COPr-n Me H H
CO2H Me H H
CO2Me Me H H
CO2Et Me H H
CO2Pr-n Me H H
CO2Bu-n Me H H
CO2Pen-n Me H H
CH2Cl Me H H
CH2Br Me H H
CH2I Me H H
CH2CF3 Me H H
CH2CN Me H H
R1 R2 R3 R4
CH2OH Me H H
CH2OMe Me H H
CH2OEt Me H H
CH2OPr-n Me H H
CH2SMe Me H H
CH2SEt Me H H
CH2SPr-n Me H H
CH2SO2Me Me H H
CH2SO2Et Me H H
CH2SO2Pr-n Me H H
CH2COMe Me H H
CH2COEt Me H H
CH2COPr-n Me H H
CH2CO2H Me H H
CH2CO2Me Me H H
CH2CO2Et Me H H
CH2CO2Pr-n Me H H
CH2OCH2CH＝CH2 Me H H
CH2OCH2C≡CH Me H H
CH＝CHCO2Me Me H H
CH＝CHCO2Et Me H H
CH＝CHCO2Pr-n Me H H
CH＝CHCN Me H H
Ph Me H H
CH2Ph Me H H
OPh Me H H
SPh Me H H
SO2Ph Me H H
CONHMe Me H H
CONHEt Me H H
CONHPr-n Me H H
CONHPr-i Me H H
CONHBu-n Me H H
CONHBu-sec Me H H
CONHBu-t Me H H
CON(Me)2 Me H H
CON(Et)2 Me H H
CON(Pr-n)2 Me H H
F Et H H
Cl Et H H
R1 R2 R3 R4
Br Et H H
I Et H H
CH＝CH2 Et H H
CH2CH＝CH2 Et H H
C≡CH Et H H
CH2C≡CH Et H H
CH2F Et H H
CHF2 Et H H
CN Et H H
NH2 Et H H
NHCOMe Et H H
CH2NH2 Et H H
CH2NHCOMe Et H H
CH2OCHF2 Et H H
CH2OCF3 Et H H
CF3 Et H H
NO2 Et H H
OMe Et H H
OEt Et H H
OPr-n Et H H
OBu-n Et H H
OPen-n Et H H
SMe Et H H
SEt Et H H
SPr-n Et H H
SBu-n Et H H
SPen-n Et H H
SO2Me Et H H
SO2Et Et H H
SO2Pr-n Et H H
COMe Et H H
COEt Et H H
COPr-n Et H H
CO2H Et H H
CO2Me Et H H
CO2Et Et H H
CO2Pr-n Et H H
CO2Bu-n Et H H
CO2Pen-n Et H H
CH2Cl Et H H
R1 R2 R3 R4
CH2Br Et H H
CH2I Et H H
CH2CF3 Et H H
CH2CN Et H H
CH2OH Et H H
CH2OMe Et H H
CH2OEt Et H H
CH2OPr-n Et H H
CH2SMe Et H H
CH2SEt Et H H
CH2SPr-n Et H H
CH2SO2Me Et H H
CH2SO2Et Et H H
CH2SO2Pr-n Et H H
CH2COMe Et H H
CH2COEt Et H H
CH2COPr-n Et H H
CH2CO2H Et H H
CH2CO2Me Et H H
CH2CO2Et Et H H
CH2CO2Pr-n Et H H
CH2OCH2CH＝CH2 Et H H
CH2OCH2C≡CH Et H H
CH＝CHCO2Me Et H H
CH＝CHCO2Et Et H H
CH＝CHCO2Pr-n Et H H
CH＝CHCN Et H H
Ph Et H H
CH2Ph Et H H
OPh Et H H
SPh Et H H
SO2Ph Et H H
CONHMe Et H H
CONHEt Et H H
CONHPr-n Et H H
CONHPr-i Et H H
CONHBu-n Et H H
CONHBu-sec Et H H
CONHBu-t Et H H
CON(Me)2 Et H H
R1 R2 R3 R4
CON(Et)2 Et H H
CON(Pr-n)2 Et H H
F H Pr-n H
Cl H Pr-n H
Br H Pr-n H
I H Pr-n H
CH＝CH2 H Pr-n H
CH2CH＝CH2 H Pr-n H
C≡CH H Pr-n H
CH2C≡CH H Pr-n H
CH2F H Pr-n H
CHF2 H Pr-n H
CN H Pr-n H
NH2 H Pr-n H
NHCOMe H Pr-n H
CH2NH2 H Pr-n H
CH2NHCOMe H Pr-n H
CH2OCHF2 H Pr-n H
CH2OCF3 H Pr-n H
CF3 H Pr-n H
NO2 H Pr-n H
OMe H Pr-n H
OEt H Pr-n H
OPr-n H Pr-n H
OBu-n H Pr-n H
OPen-n H Pr-n H
SMe H Pr-n H
SEt H Pr-n H
SPr-n H Pr-n H
SBu-n H Pr-n H
SPen-n H Pr-n H
SO2Me H Pr-n H
SO2Et H Pr-n H
SO2Pr-n H Pr-n H
COMe H Pr-n H
COEt H Pr-n H
COPr-n H Pr-n H
CO2H H Pr-n H
CO2Me H Pr-n H
CO2Et H Pr-n H
R1 R2 R3 R4
CO2Pr-n H Pr-n H
CO2Bu-n H Pr-n H
CO2Pen-n H Pr-n H
CH2Cl H Pr-n H
CH2Br H Pr-n H
CH2I H Pr-n H
CH2CF3 H Pr-n H
CH2CN H Pr-n H
CH2OH H Pr-n H
CH2OMe H Pr-n H
CH2OEt H Pr-n H
CH2OPr-n H Pr-n H
CH2SMe H Pr-n H
CH2SEt H Pr-n H
CH2SPr-n H Pr-n H
CH2SO2Me H Pr-n H
CH2SO2Et H Pr-n H
CH2SO2Pr-n H Pr-n H
CH2COMe H Pr-n H
CH2COEt H Pr-n H
CH2COPr-n H Pr-n H
CH2CO2H H Pr-n H
CH2CO2Me H Pr-n H
CH2CO2Et H Pr-n H
CH2CO2Pr-n H Pr-n H
CH2OCH2CH＝CH2 H Pr-n H
CH2OCH2C≡OH H Pr-n H
CH＝CHCO2Me H Pr-n H
CH＝CHCO2Et H Pr-n H
CH＝CHCO2Pr-n H Pr-n H
CH＝CHCN H Pr-n H
Ph H Pr-n H
CH2Ph H Pr-n H
OPh H Pr-n H
SPh H Pr-n H
SO2Ph H Pr-n H
CONHMe H Pr-n H
CONHEt H Pr-n H
CONHPr-n H Pr-n H
CONHPr-i H Pr-n H
R1 R2 R3 R4
CONHBu-n H Pr-n H
CONHBu-sec H Pr-n H
CONHBu-t H Pr-n H
CON(Me)2 H Pr-n H
CON(EO)2 H Pr-n H
CON(Pr-n)2 H Pr-n H
F H Cl H
Cl H Cl H
Br H Cl H
I H Cl H
CH＝CH2 H Cl H
CH2CH＝CH2 H Cl H
C≡CH H Cl H
CH2C≡CH H Cl H
CH2F H Cl H
CHF2 H Cl H
CN H Cl H
NH2 H Cl H
NHCOMe H Cl H
CH2NH2 H Cl H
CH2NHCOMe H Cl H
CH2OCHF2 H Cl H
CH2OCF3 H Cl H
CF3 H Cl H
NO2 H Cl H
OMe H Cl H
OEt H Cl H
OPr-n H Cl H
OBu-n H Cl H
OPen-n H Cl H
SMe H Cl H
SEt H Cl H
SPr-n H Cl H
SBu-n H Cl H
SPen-n H Cl H
SO2Me H Cl H
SO2Et H Cl H
SO2Pr-n H Cl H
COMe H Cl H
COEt H Cl H
R1 R2 R3 R4
COPr-n H Cl H
CO2H H Cl H
CO2Me H Cl H
CO2Et H Cl H
CO2Pr-n H Cl H
CO2Bu-n H Cl H
CO2Pen-n H Cl H
CH2Cl H Cl H
CH2Br H Cl H
CH2I H Cl H
CH2CF3 H Cl H
CH2CN H Cl H
CH2OH H Cl H
CH2OMe H Cl H
CH2OEt H Cl H
CH2OPr-n H Cl H
CH2SMe H Cl H
CH2SEt H Cl H
CH2SPr-n H Cl H
CH2SO2Me H Cl H
CH2SO2Et H Cl H
CH2SO2Pr-n H Cl H
CH2COMe H Cl H
CH2COEt H Cl H
CH2COPr-n H Cl H
CH2CO2H H Cl H
CH2CO2Me H Cl H
CH2CO2Et H Cl H
CH2CO2Pr-n H Cl H
CH2OCH2CH＝CH2 H Cl H
CH2OCH2C≡CH H Cl H
CH＝CHCO2Me H Cl H
CH＝CHCO2Et H Cl H
CH＝CHCO2Pr-n H Cl H
CH＝CHCN H Cl H
Ph H Cl H
CH2Ph H Cl H
OPh H Cl H
SPh H Cl H
SO2Ph H Cl H
R1 R2 R3 R4
CONHMe H Cl H
CONHEt H Cl H
CONHPr-n H Cl H
CONHPr-i H Cl H
CONHBu-n H Cl H
CONHBu-sec H Cl H
CONHBu-t H Cl H
CON(Me)2 H Cl H
CON(Et)2 H Cl H
CON(Pr-n)2 H Cl H
F H NO2 H
Cl H NO2 H
Br H NO2 H
I H NO2 H
CH＝CH2 H NO2 H
CH2CH＝CH2 H NO2 H
C≡CH H NO2 H
CH2C≡CH H NO2 H
CH2F H NO2 H
CHF2 H NO2 H
CN H NO2 H
NH2 H NO2 H
NHCOMe H NO2 H
CH2NH2 H NO2 H
CH2NHCOMe H NO2 H
CH2OCHF2 H NO2 H
CH2OCF2 H NO2 H
CF3 H NO2 H
NO2 H NO2 H
OMe H NO2 H
OEt H NO2 H
OPr-n H NO2 H
OBu-n H NO2 H
OPen-n H NO2 H
SMe H NO2 H
SEt H NO2 H
SPr-n H NO2 H
SBu-n H NO2 H
SPen-n H NO2 H
SO2Me H NO2 H
R1 R2 R3 R4
SO2Et H NO2 H
SO2Pr-n H NO2 H
COMe H NO2 H
COEt H NO2 H
COPr-n H NO2 H
CO2H H NO2 H
CO2Me H NO2 H
CO2Et H NO2 H
CO2Pr-n H NO2 H
CO2Bu-n H NO2 H
CO2Pen-n H NO2 H
CH2Cl H NO2 H
CH2Br H NO2 H
CH2I H NO2 H
CH2CF3 H NO2 H
CH2CN H NO2 H
CH2OH H NO2 H
CH2OMe H NO2 H
CH2OEt H NO2 H
CH2OPr-n H NO2 H
CH2SMe H NO2 H
CH2SEt H NO2 H
CH2SPr-n H NO2 H
CH2SO2Me H NO2 H
CH2SO2Et H NO2 H
CH2SO2Pr-n H NO2 H
CH2COMe H NO2 H
CH2COEt H NO2 H
CH2COPr-n H NO2 H
CH2CO2H H NO2 H
CH2CO2Me H NO2 H
CH2CO2Et H NO2 H
CH2CO2Pr-n H NO2 H
CH2OCH2CH＝CH2 H NO2 H
CH2OCH2C≡CH H NO2 H
CH＝CHCO2Me H NO2 H
CH＝CHCO2Et H NO2 H
CH＝CHCO2Pr-n H NO2 H
CH＝CHCN H NO2 H
Ph H NO2 H
R1 R2 R3 R4
CH2Ph H NO2 H
OPh H NO2 H
SPh H NO2 H
SO2Ph H NO2 H
CONHMe H NO2 H
CONHEt H NO2 H
CONHPr-n H NO2 H
CONHPr-i H NO2 H
CONHBu-n H NO2 H
CONHBu-sec H NO2 H
CONHBu-t H NO2 H
CON(Me)2 H NO2 H
CON(Et)2 H NO2 H
CON(Pr-n)2 H NO2 H
F H CF3 H
Cl H CF3 H
Br H CF3 H
I H CF3 H
CH＝CH2 H CF3 H
CH2CH＝CH2 H CF3 H
C≡CH H CF3 H
CH2C≡CH H CF3 H
CH2F H CF3 H
CHF2 H CF3 H
CN H CF3 H
NH2 H CF3 H
NHCOMe H CF3 H
CH2NH2 H CF3 H
CH2NHCOMe H CF3 H
CH2OCHF2 H CF3 H
CH2OCF3 H CF3 H
CF3 H CF3 H
NO2 H CF3 H
OMe H CF3 H
OEt H CF3 H
OPr-n H CF3 H
OBu-n H CF3 H
OPen-n H CF3 H
SMe H CF3 H
SEt H CF3 H
R1 R2 R3 R4
SPr-n H CF3 H
SBu-n H CF3 H
SPen-n H CF3 H
SO2Me H CF3 H
SO2Et H CF3 H
SO2Pr-n H CF3 H
COMe H CF3 H
COEt H CF3 H
COPr-n H CF3 H
CO2H H CF3 H
CO2Me H CF3 H
CO2Et H CF3 H
CO2Pr-n H CF3 H
CO2Bu-n H CF3 H
CO2Pen-n H CF3 H
CH2Cl H CF3 H
CH2Br H CF3 H
CH2I H CF3 H
CH2CF3 H CF3 H
CH2CN H CF3 H
CH2OH H CF3 H
CH2OMe H CF3 H
CH2OEt H CF3 H
CH2OPr-n H CF3 H
CH2SMe H CF3 H
CH2SEt H CF3 H
CH2SPr-n H CF3 H
CH2SO2Me H CF3 H
CH2SO2Et H CF3 H
CH2SO2Pr-n H CF3 H
CH2COMe H CF3 H
CH2COEt H CF3 H
CH2COPr-n H CF3 H
CH2CO2H H CF3 H
CH2CO2Me H CF3 H
CH2CO2Et H CF3 H
CH2CO2Pr-n H CF3 H
CH2OCH2CH＝CH2 H CF3 H
CH2OCH2C≡CH H CF3 H
CH＝CHCO2Me H CF3 H
R1 R2 R3 R4
CH＝CHCO2Et H CF3 H
CH＝CHCO2Pr-n H CF3 H
CH＝CHCN H CF3 H
Ph H CF3 H
CH2Ph H CF3 H
OPh H CF3 H
SPh H CF3 H
SO2Ph H CF3 H
HCONHMe H CF3 H
CONHEt H CF3 H
CONHPr-n H CF3 H
CONHPr-i H CF3 H
CONHBu-n H CF3 H
CONHBu-sec H CF3 H
CONHBu-t H CF3 H
CON(Me)2 H CF3 H
CON(Et)2 H CF3 H
CON(Pr-n)2 H CF3 H
R1 R2 R3 R4
F H OMe H
Cl H OMe H
Br H OMe H
I H OMe H
CH＝CH2 H OMe H
CH2CH＝CH2 H OMe H
C≡CH H OMe H
CH2C≡CH H OMe H
CH2F H OMe H
CHF2 H OMe H
CN H OMe H
NN2 H OMe H
NHCOMe H OMe H
CH2NH2 H OMe H
CH2NHCOMe H OMe H
CH2OCHF2 H OMe H
CH2OCF3 H OMe H
CF3 H OMe H
NO2 H OMe H
OMe H OMe H
OEt H OMe H
OPr-n H OMe H
OBu-n H OMe H
OPen-n H OMe H
SMe H OMe H
SEt H OMe H
SPr-n H OMe H
SBu-n H OMe H
SPen-n H OMe H
SO2Me H OMe H
SO2Et H OMe H
SO2Pr-n H OMe H
COMe H OMe H
COEt H OMe H
COPr-n H OMe H
CO2H H OMe H
CO2Me H OMe H
CO2Et H OMe H
CO2Pr-n H OMe H
CO2Bu-n H OMe H
R1 R2 R3 R4
CO2Pen-n H OMe H
CH2Cl H OMe H
CH2Br H OMe H
CH2I H OMe H
CH2CF3 H OMe H
CH2CN H OMe H
CH2OH H OMe H
CH2OMe H OMe H
CH2OEt H OMe H
CH2OPr-n H OMe H
CH2SMe H OMe H
CH2SEt H OMe H
CH2SPr-n H OMe H
CH2SO2Me H OMe H
CH2SO2Et H OMe H
CH2SO2Pr-n H OMe H
CH2COMe H OMe H
CH2COEt H OMe H
CH2COPr-n H OMe H
CH2CO2H H OMe H
CH2CO2Me H OMe H
CH2CO2Et H OMe H
CH2CO2Pr-n H OMe H
CH2OCH2CH＝CH2 H OMe H
CH2OCH2C≡CH H OMe H
CH＝CHCO2Me H OMe H
CH＝CHCO2Et H OMe H
CH＝CHCO2Pr-n H OMe H
CH＝CHCN H OMe H
Ph H OMe H
CH2Ph H OMe H
OPh H OMe H
SPh H OMe H
SO2Ph H OMe H
CONHMe H OMe H
CONHEt H OMe H
CONHPr-n H OMe H
CONHPr-i H OMe H
CONHBu-n H OMe H
CONHBu-sec H OMe H
R1 R2 R3 R4
CONHBu-t H OMe H
CON(Me)2 H OMe H
CON(Et)2 H OMe H
CON(Pr-n)2 H OMe H
F H SMe H
Cl H SMe H
Br H SMe H
I H SMe H
CH＝CH2 H SMe H
CH2CH＝CH2 H SMe H
C≡CH H SMe H
CH2C≡CH H SMe H
CH2F H SMe H
CHF2 H SMe H
CN H SMe H
NH2 H SMe H
NHCOMe H SMe H
CH2NH2 H SMe H
CH2NHCOMe H SMe H
CH2OCHF2 H SMe H
CH2OCF3 H SMe H
CF3 H SMe H
NO2 H SMe H
OMe H SMe H
OEt H SMe H
OPr-n H SMe H
OBu-n H SMe H
OPen-n H SMe H
SMe H SMe H
SEt H SMe H
SPr-n H SMe H
SBu-n H SMe H
SPen-n H SMe H
SO2Me H SMe H
SO2Et H SMe H
SO2Pr-n H SMe H
COMe H SMe H
COEt H SMe H
COPr-n H SMe H
CO2H H SMe H
R1 R2 R3 R4
CO2Me H SMe H
CO2Et H SMe H
CO2Pr-n H SMe H
CO2Bu-n H SMe H
CO2Pen-n H SMe H
CH2Cl H SMe H
CH2Br H SMe H
CH2I H SMe H
CH2CF3 H SMe H
CH2CN H SMe H
CH2OH H SMe H
CH2OMe H SMe H
CH2OEt H SMe H
CH2OPr-n H SMe H
CH2SMe H SMe H
CH2SEt H SMe H
CH2SPr-n H SMe H
CH2SO2Me H SMe H
CH2SO2Et H SMe H
CH2SO2Pr-n H SMe H
CH2COMe H SMe H
CH2COEt H SMe H
CH2COPr-n H SMe H
CH2CO2H H SMe H
CH2CO2Me H SMe H
CH2CO2Et H SMe H
CH2CO2Pr-n H SMe H
CH2OCH2CH＝CH2 H SMe H
CH2OCH2C≡CH H SMe H
CH＝CHCO2Me H SMe H
CH＝CHCO2Et H SMe H
CH＝CHCO2Pr-n H SMe H
CH＝CHCN H SMe H
Ph H SMe H
CH2Ph H SMe H
OPh H SMe H
SPh H SMe H
SO2Ph H SMe H
CONHMe H SMe H
CONHEt H SMe H
R1 R2 R3 R4
CONHPr-n H SMe H
CONHPr-i H SMe H
CONHBu-n H SMe H
CONHBu-sec H SMe H
CONHBu-t H SMe H
CON(Me)2 H SMe H
CON(Et)2 H SMe H
CON(Pr-n)2 H SMe H
F H SO2Me H
Cl H SO2Me H
Br H SO2Me H
I H SO2Me H
CH＝CH2 H SO2Me H
CH2CH＝CH2 H SO2Me H
C≡CH H SO2Me H
CH2C≡CH H SO2Me H
CH2F H SO2Me H
CHF2 H SO2Me H
CN H SO2Me H
NH2 H SO2Me H
NHCOMe H SO2Me H
CH2NH2 H SO2Me H
CH2NHCOMe H SO2Me H
CH2OCHF2 H SO2Me H
CH2OCF3 H SO2Me H
CF3 H SO2Me H
NO2 H SO2Me H
OMe H SO2Me H
OEt H SO2Me H
OPr-n H SO2Me H
OBu-n H SO2Me H
OPen-n H SO2Me H
SMe H SO2Me H
SEt H SO2Me H
SPr-n H SO2Me H
SBu-n H SO2Me H
SPen-n H SO2Me H
SO2Me H SO2Me H
SO2Et H SO2Me H
SO2Pr-n H SO2Me H
R1 R2 R3 R4
COMe H SO2Me H
COEt H SO2Me H
COPr-n H SO2Me H
CO2H H SO2Me H
CO2Me H SO2Me H
CO2Et H SO2Me H
CO2Pr-n H SO2Me H
CO2Bu-n H SO2Me H
CO2Pen-n H SO2Me H
CH2Cl H SO2Me H
CH2Br H SO2Me H
CH2I H SO2Me H
CH2CF3 H SO2Me H
CH2CN H SO2Me H
CH2OH H SO2Me H
CH2OMe H SO2Me H
CH2OEt H SO2Me H
CH2OPr-n H SO2Me H
CH2SMe H SO2Me H
CH2SEt H SO2Me H
CH2SPr-n H SO2Me H
CH2SO2Me H SO2Me H
CH2SO2Et H SO2Me H
CH2SO2Pr-n H SO2Me H
CH2COMe H SO2Me H
CH2COEt H SO2Me H
CH2COPr-n H SO2Me H
CH2CO2H H SO2Me H
CH2CO2Me H SO2Me H
CH2CO3Et H SO2Me H
CH2CO2Pr-n H SO2Me H
CH2OCH2CH＝CH2 H SO2Me H
CH2OCH2C≡CH H SO2Me H
CH＝CHCO2Me H SO2Me H
CH＝CHCO2Et H SO2Me H
CH＝CHCO2Pr-n H SO2Me H
CH＝CHCN H SO2Me H
Ph H SO2Me H
CH2Ph H SO2Me H
OPh H SO2Me H
R1 R2 R3 R4
SPh H SO2Me H
SO2Ph H SO2Me H
CONHMe H SO2Me H
CONHEt H SO2Me H
CONHPr-n H SO2Me H
CONHPr-i H SO2Me H
CONHBu-n H SO2Me H
CONHBu-sec H SO2Me H
CONHBu-t H SO2Me H
CON(Me)2 H SO2Me H
CON(Et)2 H SO2Me H
CON(Pr-n)2 H SO2Me H
F H COMe H
Cl H COMe H
Br H COMe H
I H COMe H
CH＝CH2 H COMe H
CH2CH＝CH2 H COMe H
C≡CH H COMe H
CH2C≡CH H COMe H
CH2F H COMe H
CHF2 H COMe H
CN H COMe H
NH2 H COMe H
NHCOMe H COMe H
CH2NH2 H COMe H
CH2NHCOMe H COMe H
CH2OCHF2 H COMe H
CH2OCF3 H COMe H
CF3 H COMe H
NO2 H COMe H
OMe H COMe H
OEt H COMe H
OPr-n H COMe H
OBu-n H COMe H
OPen-n H COMe H
SMe H COMe H
SEt H COMe H
SPr-n H COMe H
SBu-n H COMe H
R1 R2 R3 R4
SPen-n H COMe H
SO2Me H COMe H
SO2Et H COMe H
SO2Pr-n H COMe H
COMe H COMe H
COEt H COMe H
COPr-n H COMe H
CO2H H COMe H
CO2Me H COMe H
CO2Et H COMe H
CO2Pr-n H COMe H
CO2Bu-n H COMe H
CO2Pen-n H COMe H
CH2Cl H COMe H
CH2Br H COMe H
CH2I H COMe H
CH2CF3 H COMe H
CH2CN H COMe H
CH2OH H COMe H
CH2OMe H COMe H
CH2OEt H COMe H
CH2OPr-n H COMe H
CH2SMe H COMe H
CH2SEt H COMe H
CH2SPr-n H COMe H
CH2SO2Me H COMe H
CH2SO2Et H COMe H
CH2SO2Pr-n H COMe H
CH2COMe H COMe H
CH2COEt H COMe H
CH2COPr-n H COMe H
CH2CO2H H COMe H
CH2CO2Me H COMe H
CH2CO2Et H COMe H
CH2CO2Pr-n H COMe H
CH2OCH2CH＝CH2 H COMe H
CH2OCH2C≡CH H COMe H
CH＝CHCO2Me H COMe H
CH＝CHCO2Et H COMe H
CH＝CHCO2Pr-n H COMe H
R1 R2 R3 R4
CH＝CHCN H COMe H
Ph H COMe H
CH2Ph H COMe H
OPh H COMe H
SPh H COMe H
SO2Ph H COMe H
CONHMe H COMe H
CONHEt H COMe H
CONHPr-n H COMe H
CONHPr-i H COMe H
CONHBu-n H COMe H
CONHBu-sec H COMe H
CONHBu-t H COMe H
CON(Me)2 H COMe H
CON(Et)2 H COMe H
CON(Pr-n)2 H COMe H
F H COMe H
Cl H CO2Me H
Br H CO2Me H
I H CO2Me H
CH＝CH2 H CO2Me H
CH2CH＝CH2 H CO2Me H
C≡CH H CO2Me H
CH2C≡CH H CO2Me H
CH2F H CO2Me H
CHF2 H CO2Me H
CN H CO2Me H
NH2 H CO2Me H
NHCOMe H CO2Me H
CH2NH2 H CO2Me H
CH2NHCOMe H CO2Me H
CH2OCHF2 H CO2Me H
CH2OCF3 H CO2Me H
CF3 H CO2Me H
NO2 H CO2Me H
OMe H CO2Me H
OEt H CO2Me H
OPr-n H CO2Me H
OBu-n H CO2Me H
OPen-n H CO2Me H
R1 R2 R3 R4
SMe H CO2Me H
SEt H CO2Me H
SPr-n H CO2Me H
SBu-n H CO2Me H
SPen-n H CO2Me H
SO2Me H CO2Me H
SO2Et H CO2Me H
SO2Pr-n H CO2Me H
COMe H CO2Me H
COEt H CO2Me H
COPr-n H CO2Me H
CO2H H CO2Me H
CO2Me H CO2Me H
CO2Et H CO2Me H
CO2Prn H CO2Me H
CO2Bu-n H CO2Me H
CO2Pen-n H CO2Me H
CH2Cl H CO2Me H
CH2Br H CO2Me H
CH2I H CO2Me H
CH2CF3 H CO2Me H
CH2CN H CO2Me H
CH2OH H CO2Me H
CH2OMe H CO2Me H
CH2OEt H CO2Me H
CH2OPr-n H CO2Me H
CH2SMe H CO2Me H
CH2SEt H CO2Me H
CH2SPr-n H CO2Me H
CH2SO2Me H CO2Me H
CH2SO2Et H CO2Me H
CH2SO2Pr-n H CO2Me H
CH2COMe H CO2Me H
CH2COEt H CO2Me H
CH2COPr-n H CO2Me H
CH2CO2H H CO2Me H
CH2CO2Me H CO2Me H
CH2CO2Et H CO2Me H
CH2CO2Pr-n H CO2Me H
CH2OCH2CH＝CH2 H CO2Me H
R1 R2 R3 R4
CH2OCH2C≡CH H CO2Me H
CH＝CHCO2Me H CO2Me H
CH＝CHCO2Et H CO2Me H
CH＝CHCO2Pr-n H CO2Me H
CH＝CHCN H CO2Me H
Ph H CO2Me H
CH2Ph H CO2Me H
OPh H CO2Me H
SPh H CO2Me H
SO2Ph H CO2Me H
CONHMe H CO2Me H
CONHEt H CO2Me H
CONHPr-n H CO2Me H
CONHPr-i H CO2Me H
CONHBu-n H CO2Me H
CONHBu-sec H CO2Me H
CONHBu-t H CO2Me H
CON(Me)2 H CO2Me H
CON(Et)2 H CO2Me H
CON(Pr-n)2 H CO2Me H
F H CO2H H
Cl H CO2H H
Br H CO2H H
I H CO2H H
CH＝CH2 H CO2H H
CH2CH＝CH2 H CO2H H
C≡CH H CO2H H
CH2C≡CH H CO2H H
CH2F H CO2H H
CHF2 H CO2H H
CN H CO2H H
NH2 H CO2H H
NHCOMe H CO2H H
CH2NH2 H CO2H H
CH2NHCOMe H CO2H H
CH2OCHF2 H CO2H H
CH2OCF3 H CO2H H
CF3 H CO2H H
NO2 H CO2H H
OMe H CO2H H
R1 R2 R3 R4
OEt H CO2H H
OPr-n H CO2H H
OBu-n H CO2H H
OPen-n H CO2H H
SMe H CO2H H
SEt H CO2H H
SPr-n H CO2H H
SBu-n H CO2H H
SPen-n H CO2H H
SO2Me H CO2H H
SO2Et H CO2H H
SO2Pr-n H CO2H H
COMe H CO2H H
COEt H CO2H H
COPr-n H CO2H H
CO2H H CO2H H
CO2Me H CO2H H
CO2Et H CO2H H
CO2Pr-n H CO2H H
CO2Bu-n H CO2H H
CO2Pen-n H CO2H H
CH2Cl H CO2H H
CH2Br H CO2H H
CH2I H CO2H H
CH2CF3 H CO2H H
CH2CN H CO2H H
CH2OH H CO2H H
CH2OMe H CO2H H
CH2OEt H CO2H H
CH2OPr-n H CO2H H
CH2SMe H CO2H H
CH2SEt H CO2H H
CH2SPr-n H CO2H H
CH2SO2Me H CO2H H
CH2SO2Et H CO2H H
CH2SO2Pr-n H CO2H H
CH2COMe H CO2H H
CH2COEt H CO2H H
CH2COPr-n H CO2H H
CH2CO2H H CO2H H
R1 R2 R3 R4
CH2CO2Me H CO2H H
CH2CO2Et H CO2H H
CH2CO2Pr-n H CO2H H
CH2OCH2CH＝CH2 H CO2H H
CH2OCH2C≡CH H CO2H H
CH＝CHCO2Me H CO2H H
CH＝CHCO2Et H CO2H H
CH＝CHCO2Pr-n H CO2H H
CH＝CHCN H CO2H H
Ph H CO2H H
CH2Ph H CO2H H
OPh H CO2H H
SPh H CO2H H
SO2Ph H CO2H H
CONHMe H CO2H H
CONHEt H CO2H H
CONHPr-n H CO2H H
CONHPr-i H CO2H H
CONHBu-n H CO2H H
CONHBu-sec H CO2H H
CONHBu-t H CO2H H
CON(Me)2 H CO2H H
CON(Et)2 H CO2H H
CON(Pr-n)2 H CO2H H
F H CH2F H
Cl H CH2F H
Br H CH2F H
I H CH2F H
CH＝CH2 H CH2F H
CH2CH＝CH2 H CH2F H
C≡CH H CH2F H
CH2C≡CH H CH2F H
CH2F H CH2F H
CHF2 H CH2F H
CN H CH2F H
NH2 H CH2F H
NHCOMe H CH2F H
CH2NH2 H CH2F H
CH2NHCOMe H CH2F H
CH2OCHF2 H CH2F H
R1 R2 R3 R4
CH2OCF3 H CH2F H
CF3 H CH2F H
NO2 H CH2F H
OMe H CH2F H
OEt H CH2F H
OPr-n H CH2F H
OBu-n H CH2F H
OPen-n H CH2F H
SMe H CH2F H
SEt H CH2F H
SPr-n H CH2F H
SBu-n H CH2F H
SPen-n H CH2F H
SO2Me H CH2F H
SO2Et H CH2F H
SO2Pr-n H CH2F H
COMe H CH2F H
COEt H CH2F H
COPr-n H CH2F H
CO2H H CH2F H
CO2Me H CH2F H
CO2Et H CH2F H
CO2Pr-n H CH2F H
CO2Bu-n H CH2F H
CO2Pen-n H CH2F H
CH2Cl H CH2F H
CH2Br H CH2F H
CH2I H CH2F H
CH2CF3 H CH2F H
CH2CN H CH2F H
CH2OH H CH2F H
CH2OMe H CH2F H
CH2OEt H CH2F H
CH2OPr-n H CH2F H
CH2SMe H CH2F H
CH2SEt H CH2F H
CH2SPr-n H CH2F H
CH2SO2Me H CH2F H
CH2SO2Et H CH2F H
CH2SO2Pr-n H CH2F H
R1 R2 R3 R4
CH2COMe H CH2F H
CH2COEt H CH2F H
CH2COPr-n H CH2F H
CH2CO2H H CH2F H
CH2CO2Me H CH2F H
CH2CO2Et H CH2F H
CH2CO2Pr-n H CH2F H
CH2OCH2CH＝CH2 H CH2F H
CH2OCH2C≡CH H CH2F H
CH＝CHCO2Me H CH2F H
CH＝CHCO2Et H CH2F H
CH＝CHCO2Pr-n H CH2F H
CH＝CHCN H CH2F H
Ph H CH2F H
CH2Ph H CH2F H
OPh H CH2F H
SPh H CH2F H
SO2Ph H CH2F H
CONHMe H CH2F H
CONHEt H CH2F H
CONHPr-n H CH2F H
CONHPr-i H CH2F H
CONHBu-n H CH2F H
CONHBu-sec H CH2F H
CONHBu-t H CH2F H
CON(Me)2 H CH2F H
CON(Et)2 H CH2F H
CON(Pr-n)2 H CH2F H
F H CH2F H
Cl H CH2F H
Br H CH2F H
I H CH2F H
CH＝CH2 H CH2F H
CH2CH＝CH2 H CH2F H
C≡CH H CH2F H
CH2C≡CH H CH2F H
CH2F H CH2F H
CHF2 H CH2F H
CN H CH2F H
NH2 H CH2F H
R1 R2 R3 R4
NHCOMe H CH2Cl H
CH2NH2 H CH2Cl H
CH2NHCOMe H CH2Cl H
CH2OCHF2 H CH2Cl H
CH2OCF3 H CH2Cl H
CF3 H CH2Cl H
NO2 H CH2Cl H
OMe H CH2Cl H
OEt H CH2Cl H
OPr-n H CH2Cl H
OBu-n H CH2Cl H
OPen-n H CH2Cl H
SMe H CH2Cl H
SEt H CH2Cl H
SPr-n H CH2Cl H
SBu-n H CH2Cl H
SPen-n H CH2Cl H
SO2Me H CH2Cl H
SO2Et H CH2Cl H
SO2Pr-n H CH2Cl H
COMe H CH2Cl H
COEt H CH2Cl H
COPr-n H CH2Cl H
CO2H H CH2Cl H
CO2Me H CH2Cl H
CO2Et H CH2Cl H
CO2Pr-n H CH2Cl H
CO2Bu-n H CH2Cl H
CO2Pen-n H CH2Cl H
CH2Cl H CH2Cl H
CH2Br H CH2Cl H
CH2I H CH2Cl H
CH2CF3 H CH2Cl H
CH2CN H CH2Cl H
CH2OH H CH2Cl H
CH2OMe H CH2Cl H
CH2OEt H CH2Cl H
CH2OPr-n H CH2Cl H
CH2SNe H CH2Cl H
CH2SEt H CH2Cl H
R1 R2 R3 R4
CH2SPr-n H CH2Cl H
CH2SO2Me H CH2Cl H
CH2SO2Et H CH2Cl H
CH2SO2Pr-n H CH2Cl H
CH2COMe H CH2Cl H
CH2COEt H CH2Cl H
CH2COPr-n H CH2Cl H
CH2CO2H H CH2Cl H
CH2CO2Me H CH2Cl H
CH2CO2Et H CH2Cl H
CH2CO2Pr-n H CH2Cl H
CH2OCH2CH＝CH2 H CH2Cl H
CH2OCH2C≡CH H CH2Cl H
CH＝CHCO2Me H CH2Cl H
CH＝CHCO2Et H CH2Cl H
CH＝CHCO2Pr-n H CH2Cl H
CH＝CHCN H CH2Cl H
Ph H CH2Cl H
CH2Ph H CH2Cl H
OPh H CH2Cl H
SPh H CH2Cl H
SO2Ph H CH2Cl H
CONHMe H CH2Cl H
CONHEt H CH2Cl H
CONHPr-n H CH2Cl H
CONHPr-i H CH2Cl H
CONHBu-n H CH2Cl H
CONHBu-sec H CH2Cl H
CONHBu-t H CH2Cl H
CON(Me)2 H CH2Cl H
CON(EO)2 H CH2Cl H
CON(Pr-n)2 H CH2Cl H
F H CH2Cl H
Cl H CH2Cl H
Br H CH2Cl H
I H CH2Cl H
CH＝CH2 H CH2Cl H
CH2CH＝CH2 H CH2Cl H
C≡CH H CH2Cl H
CH2C≡CH H CH2Cl H
R1 R2 R3 R4
CH2F H CH2OMe H
CHF2 H CH2OMe H
CN H CH2OMe H
NH2 H CH2OMe H
NHCOMe H CH2OMe H
CH2NH2 H CH2OMe H
CH2NHCOMe H CH2OMe H
CH2OCHF2 H CH2OMe H
CH2OCF3 H CH2OMe H
CF3 H CH2OMe H
NO2 H CH2OMe H
OMe H CH2OMe H
OEt H CH2OMe H
OPr-n H CH2OMe H
OBu-n H CH2OMe H
OPen-n H CH2OMe H
SMe H CH2OMe H
SEt H CH2OMe H
SPr-n H CH2OMe H
SBu-n H CH2OMe H
SPen-n H CH2OMe H
SO2Me H CH2OMe H
SO2Et H CH2OMe H
SO2Pr-n H CH2OMe H
COMe H CH2OMe H
COEt H CH2OMe H
COPr-n H CH2OMe H
CO2H H CH2OMe H
CO2Me H CH2OMe H
CO2Et H CH2OMe H
CO2Pr-n H CH2OMe H
CO2Bu-n H CH2OMe H
CO2Pen-n H CH2OMe H
CH2Cl H CH2OMe H
CH2Br H CH2OMe H
CH2I H CH2OMe H
CH2CF3 H CH2OMe H
CH2CN H CH2OMe H
CH2OH H CH2OMe H
CH2OMe H CH2OMe H
R1 R2 R3 R4
CH2OEt H CH2OMe H
CH2OPr-n H CH2OMe H
CH2SMe H CH2OMe H
CH2SEt H CH2OMe H
CH2SPr-n H CH2OMe H
CH2SO2Me H CH2OMe H
CH2SO2Et H CH2OMe H
CH2SO2Pr-n H CH2OMe H
CH2COMe H CH2OMe H
CH2COEt H CH2OMe H
CH2COPr-n H CH2OMe H
CH2CO2H H CH2OMe H
CH2CO2Me H CH2OMe H
CH2CO2Et H CH2OMe H
CH2CO2Pr-n H CH2OMe H
CH2OCH2CH＝CH2 H CH2OMe H
CH2OCH2C≡CH H CH2OMe H
CH＝CHCO2Me H CH2OMe H
CH＝CHCO2Et H CH2OMe H
CH＝CHCO2Pr-n H CH2OMe H
CH＝CHCN H CH2OMe H
Ph H CH2OMe H
CH2Ph H CH2OMe H
OPh H CH2OMe H
SPh H CH2OMe H
SO2Ph H CH2OMe H
CONHMe H CH2OMe H
CONHEt H CH2OMe H
CONHPr-n H CH2OMe H
CONHPr-i H CH2OMe H
CONHBu-n H CH2OMe H
CONHBu-sec H CH2OMe H
CONHBu-t H CH2OMe H
CON(Me)2 H CH2OMe H
CON(Et)2 H CH2OMe H
CON(Pr-n)2 H CH2OMe H
F H CH2OMe H
Cl H CH2OMe H
Br H CH2OMe H
I H CH2OMe H
R1 R2 R3 R4
CH＝CH2 H CH2SMe H
CH2CH＝CH2 H CH2SMe H
C≡CH H CH2SMe H
CH2C≡CH H CH2SMe H
CH2F H CH2SMe H
CHF2 H CH2SMe H
CN H CH2SMe H
NH2 H CH2SMe H
NHCOMe H CH2SMe H
CH2NH2 H CH2SMe H
CH2NHCOMe H CH2SMe H
CH2OCHF2 H CH2SMe H
CH2OCF3 H CH2SMe H
CF3 H CH2SMe H
NO2 H CH2SMe H
OMe H CH2SMe H
OEt H CH2SMe H
OPr-n H CH2SMe H
OBu-n H CH2SMe H
OPen-n H CH2SMe H
SMe H CH2SMe H
SEt H CH2SMe H
SPr-n H CH2SMe H
SBu-n H CH2SMe H
SPen-n H CH2SMe H
SO2Me H CH2SMe H
SO2Et H CH2SMe H
SO2Pr-n H CH2SMe H
COMe H CH2SMe H
COEt H CH2SMe H
COPr-n H CH2SMe H
CO2H H CH2SMe H
CO2Me H CH2SMe H
CO2Et H CH2SMe H
CO2Pr-n H CH2SMe H
CO2Bu-n H CH2SMe H
CO2Pen-n H CH2SMe H
CH2Cl H CH2SMe H
CH2Br H CH2SMe H
CH2I H CH2SMe H
R1 R2 R3 R4
CH2CF3 H CH2SMe H
CH2CN H CH2SMe H
CH2OH H CH2SMe H
CH2OMe H CH2SMe H
CH2OEt H CH2SMe H
CH2OPr-n H CH2SMe H
CH2SMe H CH2SMe H
CH2SEt H CH2SMe H
CH2SPr-n H CH2SMe H
CH2SO2Me H CH2SMe H
CH2SO2Et H CH2SMe H
CH2SO2Pr-n H CH2SMe H
CH2COMe H CH2SMe H
CH2COEt H CH2SMe H
CH2COPr-n H CH2SMe H
CH2CO2H H CH2SMe H
CH2CO2Me H CH2SMe H
CH2CO2Et H CH2SMe H
CH2CO2Pr-n H CH2SMe H
CH2OCH2CH＝CH2 H CH2SMe H
CH2OCH2C≡CH H CH2SMe H
CH＝CHCO2Me H CH2SMe H
CH＝CHCO2Et H CH2SMe H
CH＝CHCO2Pr-n H CH2SMe H
CH＝CHCN H CH2SMe H
Ph H CH2SMe H
CH2Ph H CH2SMe H
OPh H CH2SMe H
SPh H CH2SMe H
SO2Ph H CH2SMe H
CONHMe H CH2SMe H
CONHEt H CH2SMe H
CONHPr-n H CH2SMe H
CONHPr-i H CH2SMe H
CONHBu-n H CH2SMe H
CONHBu-sec H CH2SMe H
CONHBu-t H CH2SMe H
CON(Me)2 H CH2SMe H
CON(Et)2 H CH2SMe H
CON(Pr-n)2 H CH2SMe H
R1 R2 R3 R4
F H CH2SO2Me H
Cl H CH2SO2Me H
Br H CH2SO2Me H
I H CH2SO2Me H
CH＝CH2 H CH2SO2Me H
CH2CH＝CH2 H CH2SO2Me H
C≡CH H CH2SO2Me H
CH2C≡CH H CH2SO2Me H
CH2F H CH2SO2Me H
CHF2 H CH2SO2Me H
CN H CH2SO2Me H
NH2 H CH2SO2Me H
NHCOMe H CH2SO2Me H
CH2NH2 H CH2SO2Me H
CH2NHCOMe H CH2SO2Me H
CH2OCHF2 H CH2SO2Me H
CH2OCF3 H CH2SO2Me H
CF3 H CH2SO2Me H
NO2 H CH2SO2Me H
OMe H CH2SO2Me H
OEt H CH2SO2Me H
OPr-n H CH2SO2Me H
OBu-n H CH2SO2Me H
OPen-n H CH2SO2Me H
SMe H CH2SO2Me H
SEt H CH2SO2Me H
SPr-n H CH2SO2Me H
SBu-n H CH2SO2Me H
SPen-n H CH2SO2Me H
SO2Me H CH2SO2Me H
SO2Et H CH2SO2Me H
SO2Prn H CH2SO2Me H
COMe H CH2SO2Me H
COEt H CH2SO2Me H
COPr-n H CH2SO2Me H
CO2H H CH2SO2Me H
CO2Me H CH2SO2Me H
CO2Et H CH2SO2Me H
CO2Pr-n H CH2SO2Me H
CO2Bu-n H CH2SO2Me H
R1 R2 R3 R4
CO2Pen-n H CH2SO2Me H
CH2Cl H CH2SO2Me H
CH2Br H CH2SO2Me H
CH2I H CH2SO2Me H
CH2CF3 H CH2SO2Me H
CH2CN H CH2SO2Me H
CH2OH H CH2SO2Me H
CH2OMe H CH2SO2Me H
CH2OEt H CH2SO2Me H
CH2OPr-n H CH2SO2Me H
CH2SMe H CH2SO2Me H
CH2SEt H CH2SO2Me H
CH2SPr-n H CH2SO2Me H
CH2SO2Me H CH2SO2Me H
CH2SO2Et H CH2SO2Me H
CH2SO2Pr-n H CH2SO2Me H
CH2COMe H CH2SO2Me H
CH2COEt H CH2SO2Me H
CH2COPr-n H CH2SO2Me H
CH2CO2H H CH2SO2Me H
CH2CO2Me H CH2SO2Me H
CH2CO2Et H CH2SO2Me H
CH2CO2Pr-n H CH2SO2Me H
CH2OCH2CH＝CH2 H CH2SO2Me H
CH2OCH2C≡CH H CH2SO2Me H
CH＝CHCO2Me H CH2SO2Me H
CH＝CHCO2Et H CH2SO2Me H
CH＝CHCO2Pr-n H CH2SO2Me H
CH＝CHCN H CH2SO2Me H
Ph H CH2SO2Me H
CH2Ph H CH2SO2Me H
OPh H CH2SO2Me H
SPh H CH2SO2Me H
SO2Ph H CH2SO2Me H
CONHMe H CH2SO2Me H
CONHEt H CH2SO2Me H
CONHPr-n H CH2SO2Me H
CONHPr-i H CH2SO2Me H
CONHBu-n H CH2SO2Me H
CONHBu-sec H CH2SO2Me H
R1 R2 R3 R4
CONHBu-t H CH2SO2Me H
CON(Me)2 H CH2SO2Me H
CON(Et)2 H CH2SO2Me H
CON(Pr-n)2 H CH2SO2Me H
F H CH2SO2Me H
Cl H CH2SO2Me H
Br H CH2SO2Me H
I H CH2SO2Me H
CH＝CH2 H CH2SO2Me H
CH2CH＝CH2 H CH2SO2Me H
C≡CH H CH2SO2Me H
CH2C≡CH H CH2SO2Me H
CH2F H CH2SO2Me H
CHF2 H CH2SO2Me H
CN H CH2SO2Me H
NH2 H CH2SO2Me H
NHCOMe H CH2SO2Me H
CH2NH2 H CH2SO2Me H
CH2NHCOMe H CH2SO2Me H
CH2OCHF2 H CH2SOMe H
CH2OCF3 H CH2SO2Me H
CF3 H CH2SO2Me H
NO2 H CH2SO2Me H
OMe H CH2SO2Me H
OEt H CH2SO2Me H
OPr-n H CH2SO2Me H
OBu-n H CH2SO2Me H
OPen-n H CH2SO2Me H
SMe H CH2SO2Me H
SEt H CH2SO2Me H
SPr-n H CH2SO2Me H
SBu-n H CH2SO2Me H
SPen-n H CH2SO2Me H
SO2Me H CH2SO2Me H
SO2Et H CH2SO2Me H
SO2Pr-n H CH2SO2Me H
COMe H CH2SO2Me H
COEt H CH2SO2Me H
COPr-n H CH2SO2Me H
CO2H H CH2SO2Me H
R1 R2 R3 R4
CO2Me H CH2CO2Me H
CO2Et H CH2CO2Me H
CO2Pr-n H CH2CO2Me H
CO2Bu-n H CH2CO2Me H
CO2Pen-n H CH2CO2Me H
CH2Cl H CH2CO2Me H
CH2Br H CH2CO2Me H
CH2I H CH2CO2Me H
CH2CF3 H CH2CO2Me H
CH2CN H CH2CO2Me H
CH2OH H CH2CO2Me H
CH2OMe H CH2CO2Me H
CH2OEt H CH2CO2Me H
CH2OPr-n H CH2CO2Me H
CH2SMe H CH2CO2Me H
CH2SEt H CH2CO2Me H
CH2SPr-n H CH2CO2Me H
CH2SO2Me H CH2CO2Me H
CH2SO2Et H CH2CO2Me H
CH2SO2Pr-n H CH2CO2Me H
CH2COMe H CH2CO2Me H
CH2COEt H CH2CO2Me H
CH2COPr-n H CH2CO2Me H
CH2CO2H H CH2CO2Me H
CH2CO2Me H CH2CO2Me H
CH2CO2Et H CH2CO2Me H
CH2CO2Pr-n H CH2CO2Me H
CH2OCH2CH＝CH2 H CH2CO2Me H
CH2OCH2C≡CH H CH2CO2Me H
CH＝CHCO2Me H CH2CO2Me H
CH＝CHCO2Et H CH2CO2Me H
CH＝CHCO2Pr-n H CH2CO2Me H
CH＝CHCN H CH2CO2Me H
Ph H CH2CO2Me H
CH2Ph H CH2CO2Me H
OPh H CH2CO2Me H
SPh H CH2CO2Me H
SO2Ph H CH2CO2Me H
CONHMe H CH2CO2Me H
CONHEt H CH2CO2Me H
R1 R2 R3 R4
CONHPr-n H CH2CO2Me H
CONHPr-i H CH2CO2Me H
CONHBu-n H CH2CO2Me H
CONHBu-sec H CH2CO2Me H
CONHBu-t H CH2CO2Me H
CON(Me)2 H CH2CO2Me H
CON(Et)2 H CH2CO2Me H
CON(Pr-n)2 H CH2CO2Me H
F H Ph H
Cl H Ph H
Br H Ph H
I H Ph H
CH＝CH2 H Ph H
CH2CH＝CH2 H Ph H
C≡CH H Ph H
CH2C≡CH H Ph H
CH2F H Ph H
CHF2 H Ph H
CN H Ph H
NH2 H Ph H
NHCOMe H Ph H
CH2NH2 H Ph H
CH2NHCOMe H Ph H
CH2OCHF2 H Ph H
CH2OCF3 H Ph H
CF3 H Ph H
NO2 H Ph H
OMe H Ph H
OEt H Ph H
OPr-n H Ph H
OBu-n H Ph H
OPen-n H Ph H
SMe H Ph H
SEt H Ph H
SPr-n H Ph H
SBu-n H Ph H
SPen-n H Ph H
SO2Me H Ph H
SO2Et H Ph H
SO2Pr-n H Ph H
R1 R2 R3 R4
COMe H Ph H
COEt H Ph H
COPr-n H Ph H
CO2H H Ph H
CO2Me H Ph H
CO2Et H Ph H
CO2Pr-n H Ph H
CO2Bu-n H Ph H
CO2Pen-n H Ph H
CH2Cl H Ph H
CH2Br H Ph H
CH2I H Ph H
CH2CF3 H Ph H
CH2CN H Ph H
CH2OH H Ph H
CH2OMe H Ph H
CH2OEt H Ph H
CH2OPr-n H Ph H
CH2SMe H Ph H
CH2SEt H Ph H
CH2SPr-n H Ph H
CH2SO2Me H Ph H
CH2SO2Et H Ph H
CH2SO2Pr-n H Ph H
CH2COMe H Ph H
CH2COEt H Ph H
CH2COPr-n H Ph H
CH2CO2H H Ph H
CH2CO2Me H Ph H
CH2CO2Et H Ph H
CH2CO2Pr-n H Ph H
CH2OCH2CH＝CH2 H Ph H
CH2OCH2C≡CH H Ph H
CH＝CHCO2Me H Ph H
CH＝CHCO2Et H Ph H
CH＝CHCO2Pr-n H Ph H
CH＝CHCN H Ph H
Ph H Ph H
CH2Ph H Ph H
OPh H Ph H
R1 R2 R3 R4
SPh H Ph H
SO2Ph H Ph H
CONHMe H Ph H
CONHEt H Ph H
CONHPr-n H Ph H
CONHPr-i H Ph H
CONHBu-n H Ph H
CONHBu-sec H Ph H
CONHBu-t H Ph H
CON(Me)2 H Ph H
CON(Et)2 H Ph H
CON(Pr-n)2 H Ph H
F H CH2Ph H
Cl H CH2Ph H
Br H CH2Ph H
I H CH2Ph H
CH＝CH2 H CH2Ph H
CH2CH＝CH2 H CH2Ph H
C≡CH H CH2Ph H
CH2C≡CH H CH2Ph H
CH2F H CH2Ph H
CHF2 H CH2Ph H
CN H CH2Ph H
NH2 H CH2Ph H
NHCOMe H CH2Ph H
CH2NH2 H CH2Ph H
CH2NHCOMe H CH2Ph H
CH2OCHF2 H CH2Ph H
CH2OCF3 H CH2Ph H
CF3 H CH2Ph H
NO2 H CH2Ph H
OMe H CH2Ph H
OEt H CH2Ph H
OPr-n H CH2Ph H
OBu-n H CH2Ph H
OPen-n H CH2Ph H
SMe H CH2Ph H
SEt H CH2Ph H
SPr-n H CH2Ph H
SBu-n H CH2Ph H
R1 R2 R3 R4
SPen-n H CH2Ph H
SO2Me H CH2Ph H
SO2Et H CH2Ph H
SO2Pr-n H CH2Ph H
COMe H CH2Ph H
COEt H CH2Ph H
COPr-n H CH2Ph H
CO2H H CH2Ph H
CO2Me H CH2Ph H
CO2Et H CH2Ph H
CO2Pr-n H CH2Ph H
CO2Bu-n H CH2Ph H
CO2Pen-n H CH2Ph H
CH2Cl H CH2Ph H
CH2Br H CH2Ph H
CH2I H CH2Ph H
CH2CF3 H CH2Ph H
CH2CN H CH2Ph H
CH2OH H CH2Ph H
CH2OMe H CH2Ph H
CH2OEt H CH2Ph H
CH2OPr-n H CH2Ph H
CH2SMe H CH2Ph H
CH2SEt H CH2Ph H
CH2SPr-n H CH2Ph H
CH2SO2Me H CH2Ph H
CH2SO2Et H CH2Ph H
CH2SO2Pr-n H CH2Ph H
CH2COMe H CH2Ph H
CH2COEt H CH2Ph H
CH2COPr-n H CH2Ph H
CH2CO2H H CH2Ph H
CH2CO2Me H CH2Ph H
CH2CO2Et H CH2Ph H
CH2CO2Pr-n H CH2Ph H
CH2OCH2CH＝CH2 H CH2Ph H
CH2OCH2C≡CH H CH2Ph H
CH＝CHCO2Me H CH2Ph H
CH＝CHCO2Et H CH2Ph H
CH＝CHCO2Pr-n H CH2Ph H
R1 R2 R3 R4
CH＝CHCN H CH2Ph H
Ph H CH2Ph H
CH2Ph H CH2Ph H
OPh H CH2Ph H
SPh H CH2Ph H
SO2Ph H CH2Ph H
CONHMe H CH2Ph H
CONHEt H CH2Ph H
CONHPr-n H CH2Ph H
CONHPr-i H CH2Ph H
CONHBu-n H CH2Ph H
CONHBu-sec H CH2Ph H
CONHBu-t H CH2Ph H
CON(Me)2 H CH2Ph H
CON(Et)2 H CH2Ph H
CON(Pr-n)2 H CH2Ph H
F H OPh H
Cl H OPh H
Br H OPh H
I H OPh H
CH＝CH2 H OPh H
CH2CH＝CH2 H OPh H
C≡CH H OPh H
CH2C≡CH H OPh H
CH2F H OPh H
CHF2 H OPh H
CN H OPh H
NH2 H OPh H
NHCOMe H OPh H
CH2NH2 H OPh H
CH2NHCOMe H OPh H
CH2OCHF2 H OPh H
CH2OCF3 H OPh H
CF3 H OPh H
NO2 H OPh H
OMe H OPh H
OEt H OPh H
OPr-n H OPh H
OBu-n H OPh H
OPen-n H OPh H
R1 R2 R3 R4
SMe H OPh H
SEt H OPh H
SPr-n H OPh H
SBu-n H OPh H
SPen-n H OPh H
SO2Me H OPh H
SO2Et H OPh H
SO2Pr-n H OPh H
COMe H OPh H
COEt H OPh H
COPr-n H OPh H
CO2H H OPh H
CO2Me H OPh H
CO2Et H OPh H
CO2Pr-n H OPh H
CO2Bu-n H OPh H
CO2Pen-n H OPh H
CH2Cl H OPh H
CH2Br H OPh H
CH2I H OPh H
CH2CF3 H OPh H
CH2CN H OPh H
CH2OH H OPh H
CH2OMe H OPh H
CH2OEt H OPh H
CH2OPr-n H OPh H
CH2SMe H OPh H
CH2SEt H OPh H
CH2SPr-n H OPh H
CH2SO2Me H OPh H
CH2SO2Et H OPh H
CH2SO2Pr-n H OPh H
CH2COMe H OPh H
CH2COEt H OPh H
CH2COPr-n H OPh H
CH2CO2H H OPh H
CH2CO2Me H OPh H
CH2CO2Et H OPh H
CH2CO2Pr-n H OPh H
CH2OCH2CH＝CH2 H OPh H
R1 R2 R3 R4
CH2OCH2C≡CH H OPh H
CH＝CHCO2Me H OPh H
CH＝CHCO2Et H OPh H
CH＝CHCO2Pr-n H OPh H
CH＝CHCN H OPh H
Ph H OPh H
CH2Ph H OPh H
OPh H OPh H
SPh H OPh H
SO2Ph H OPh H
CONHMe H OPh H
CONHEt H OPh H
CONHPr-n H OPh H
CONHPr-i H OPh H
CONHBu-n H OPh H
CONHBu-sec H OPh H
CONHBu-t H OPh H
CON(Me)2 H OPh H
CON(Et)2 H OPh H
CON(Pr-n)2 H OPh H
F H SPh H
Cl H SPh H
Br H SPh H
I H SPh H
CH＝CH2 H SPh H
CH2CH＝CH2 H SPh H
C≡CH H SPh H
CH2C≡CH H SPh H
CH2F H SPh H
CHF2 H SPh H
CN H SPh H
NH2 H SPh H
NHCOMe H SPh H
CH2NH2 H SPh H
CH2NHCOMe H SPh H
CH2OCHF2 H SPh H
CH2OCF3 H SPh H
CF3 H SPh H
NO2 H SPh H
OMe H SPh H
R1 R2 R3 R4
OEt H SPh H
OPr-n H SPh H
OBu-n H SPh H
OPen-n H SPh H
SMe H SPh H
SEt H SPh H
SPr-n H SPh H
SBu-n H SPh H
SPen-n H SPh H
SO2Me H SPh H
SO2Et H SPh H
SO2Pr-n H SPh H
COMe H SPh H
COEt H SPh H
COPr-n H SPh H
CO2H H SPh H
CO2Me H SPh H
CO2Et H SPh H
CO2Pr-n H SPh H
CO2Bu-n H SPh H
CO2Pen-n H SPh H
CH2Cl H SPh H
CH2Br H SPh H
CH2I H SPh H
CH2CF3 H SPh H
CH2CN H SPh H
CH2OH H SPh H
CH2OMe H SPh H
CH2OEt H SPh H
CH2OPr-n H SPh H
CH2SMe H SPh H
CH2SEt H SPh H
CH2SPr-n H SPh H
CH2SO2Me H SPh H
CH2SO2Ht H SPh H
CH2SO2Pr-n H SPh H
CH2COMe H SPh H
CH2COEt H SPh H
CH2COPr-n H SPh H
CH2CO2H H SPh H
R1 R2 R3 R4
CH2CO2Me H SPh H
CH2CO2Et H SPh H
CH2CO2Pr-n H SPh H
CH2OCH2CH＝CH2 H SPh H
CH2OCH2C≡OH H SPh H
CH＝CHCO2Me H SPh H
CH＝CHCO2Et H SPh H
CH＝CHCO2Pr-n H SPh H
CH＝CHCN H SPh H
Ph H SPh H
CH2Ph H SPh H
OPh H SPh H
SPh H SPh H
SO2Ph H SPh H
CONHMe H SPh H
CONHEt H SPh H
CONHPr-n H SPh H
CONHPr-i H SPh H
CONHBu-n H SPh H
CONHBu-sec H SPh H
CONHBu-t H SPh H
CON(Me)2 H SPh H
CON(Et)2 H SPh H
CON(Pr-n)2 H SPh H
F H SO2Ph H
Cl H SO2Ph H
Br H SO2Ph H
I H SO2Ph H
CH＝CH2 H SO2Ph H
CH2CH＝CH2 H SO2Ph H
C≡CH H SO2Ph H
CH2C≡CH H SO2Ph H
CH2F H SO2Ph H
CHF2 H SO2Ph H
CN H SO2Ph H
NH2 H SO2Ph H
NHCOMe H SO2Ph H
CH2NH2 H SO2Ph H
CH2NHCOMe H SO2Ph H
CH2OCHF2 H SO2Ph H
R1 R2 R3 R4
CH2OCF3 H SO2Ph H
CF3 H SO2Ph H
NO2 H SO2Ph H
OMe H SO2Ph H
OEt H SO2Ph H
OPr-n H SO2Ph H
OBu-n H SO2Ph H
OPen-n H SO2Ph H
SMe H SO2Ph H
SEt H SO2Ph H
SPr-n H SO2Ph H
SBu-n H SO2Ph H
SPen-n H SO2Ph H
SO2Me H SO2Ph H
SO2Et H SO2Ph H
SO2Pr-n H SO2Ph H
COMe H SO2Ph H
COEt H SO2Ph H
COPr-n H SO2Ph H
CO2H H SO2Ph H
CO2Me H SO2Ph H
CO2Et H SO2Ph H
CO2Pr-n H SO2Ph H
CO2Bu-n H SO2Ph H
CO2Pen-n H SO2Ph H
CH2Cl H SO2Ph H
CH2Br H SO2Ph H
CH2I H SO2Ph H
CH2CF3 H SO2Ph H
CH2CN H SO2Ph H
CH2OH H SO2Ph H
CH2OMe H SO2Ph H
CH2OEt H SO2Ph H
CH2OPr-n H SO2Ph H
CH2SMe H SO2Ph H
CH2SEt H SO2Ph H
CH2SPr-n H SO2Ph H
CH2SO2Me H SO2Ph H
CH2SO2Et H SO2Ph H
CH2SO2Pr-n H SO2Ph H
R1 R2 R3 R4
CH2COMe H SO2Ph H
CH2COEt H SO2Ph H
CH2COPr-n H SO2Ph H
CH2CO2H H SO2Ph H
CH2CO2Me H SO2Ph H
CH2CO2Et H SO2Ph H
CH2CO2Pr-n H SO2Ph H
CH2OCH2CH＝CH2 H SO2Ph H
CH2OCH2C≡CH H SO2Ph H
CH＝CHCO2Me H SO2Ph H
CH＝CHCO2Et H SO2Ph H
CH＝CHCO2Pr-n H SO2Ph H
CH＝CHCN H SO2Ph H
Ph H SO2Ph H
CH2Ph H SO2Ph H
OPh H SO2Ph H
SPh H SO2Ph H
SO2Ph H SO2Ph H
CONHMe H SO2Ph H
CONHEt H SO2Ph H
CONHPr-n H SO2Ph H
CONHPr-i H SO2Ph H
CONHBu-n H SO2Ph H
CONHBu-sec H SO2Ph H
CONHBu-t H SO2Ph H
CON(Me)2 H SO2Ph H
CON(Et)2 H SO2Ph H
CON(Pr-n)2 H SO2Ph H
F H CON(Et)2 H
Cl H CON(Et)2 H
Br H CON(Et)2 H
I H CON(Et)2 H
CH＝CH2 H CON(Et)2 H
CH2CH＝CH2 H CON(Et)2 H
C≡CH H CON(Et)2 H
CH2C≡CH H CON(Et)2 H
CH2F H CON(Et)2 H
CHF2 H CON(Et)2 H
CN H CON(Et)2 H
NH2 H CON(Et)2 H
R1 R2 R3 R4
NHCOMe H CON(Et)2 H
CH2NH2 H CON(Et)2 H
CH2NHCOMe H CON(Et)2 H
CH2OCHF2 H CON(Et)2 H
CH2OCF3 H CON(Et)2 H
CF3 H CON(Et)2 H
NO2 H CON(Et)2 H
OMe H CON(Et)2 H
OEt H CON(Et)2 H
OPr-n H CON(Et)2 H
OBu-n H CON(Et)2 H
OPen-n H CON(Et)2 H
SMe H CON(Et)2 H
SEt H CON(Et)2 H
SPr-n H CON(Et)2 H
SBu-n H CON(Et)2 H
SPen-n H CON(Et)2 H
SO2Me H CON(Et)2 H
SO2Et H CON(Et)2 H
SO2Pr-n H CON(Et)2 H
COMe H CON(Et)2 H
COEt H CON(Et)2 H
COPr-n H CON(Et)2 H
CO2H H CON(Et)2 H
CO2Me H CON(Et)2 H
CO2Et H CON(Et)2 H
CO2Pr-n H CON(Et)2 H
CO2Bu-n H CON(Et)2 H
CO2Pen-n H CON(Et)2 H
CH2Cl H CON(Et)2 H
CH2Br H CON(Et)2 H
CH2I H CON(Et)2 H
CH2CF3 H CON(Et)2 H
CH2CN H CON(Et)2 H
CH2OH H CON(Et)2 H
CH2OMe H CON(Et)2 H
CH2OEt H CON(Et)2 H
CH2OPr-n H CON(Et)2 H
CH2SMe H CON(Et)2 H
CH2SEt H CON(Et)2 H
R1 R2 R3 R4
CH2SPr-n H CON(Et)2 H
CH2SO2Me H CON(Et)2 H
CH2SO2Et H CON(Et)2 H
CH2SO2Pr-n H CON(Et)2 H
CH2COMe H CON(Et)2 H
CH2COEt H CON(Et)2 H
CH2COPr-n H CON(Et)2 H
CH2CO2H H CON(Et)2 H
CH2CO2Me H CON(Et)2 H
CH2CO2Et H CON(Et)2 H
CH2CO2Pr-n H CON(Et)2 H
CH2OCH2CH＝CH2 H CON(Et)2 H
CH2OCH2C≡CH H CON(Et)2 H
CH＝CHCO2Me H CON(Et)2 H
CH＝CHCO2Et H CON(Et)2 H
CH＝CHCO2Pr-n H CON(Et)2 H
CH＝CHCN H CON(Et)2 H
Ph H CON(Et)2 H
CH2Ph H CON(Et)2 H
OPh H CON(Et)2 H
SPh H CON(Et)2 H
SO2Ph H CON(Et)2 H
CONHMe H CON(Et)2 H
CONHEt H CON(Et)2 H
CONHPr-n H CON(Et)2 H
CONHPr-i H CON(Et)2 H
CONHBu-n H CON(Et)2 H
CONHBu-sec H CON(Et)2 H
CONHBu-t H CON(Et)2 H
CON(Me)2 H CON(Et)2 H
CON(Et)2 H CON(Et)2 H
CON(Pr-n)2 H CON(Et)2 H
F H CN H
Cl H CN H
Br H CN H
I H CN H
CH＝CH2 H CN H
CH2CH＝CH2 H CN H
C≡CH H CN H
CH2C≡CH H CN H
R1 R2 R3 R4
CH2F H CN H
CHF2 H CN H
CN H CN H
NH2 H CN H
NHCOMe H CN H
CH2NH2 H CN H
CH2NHCOMe H CN H
CH2OCHF2 H CN H
CH2OCF3 H CN H
CF3 H CN H
NO2 H CN H
OMe H CN H
OEt H CN H
OPr-n H CN H
OBu-n H CN H
OPen-n H CN H
SMe H CN H
SEt H CN H
SPr-n H CN H
SBu-n H CN H
SOPen-n H CN H
SO2Me H CN H
SO2Et H CN H
SO2Pr-n H CN H
COMe H CN H
COEt H CN H
COPr-n H CN H
CO2H H CN H
CO2Me H CN H
CO2Et H CN H
CO2Pr-n H CN H
CO2Bu-n H CN H
CO2Pen-n H CN H
CH2Br H CN H
CH2I H CN H
CH2CF3 H CN H
CH2CN H CN H
CH2OH H CN H
CH2OMe H CN H
R1 R2 R3 R4
CH2OEt H CN H
CH2OPr-n H CN H
CH2SMe H CN H
CH2SEt H CN H
CH2SPr-n H CN H
CH2SO2Me H CN H
CH2SO2Et H CN H
CH2SO2Pr-n H CN H
CH2COMe H CN H
CH2COEt H CN H
CH2COPr-n H CN H
CH2CO2H H CN H
CH2CO2Me H CN H
CH2CO2Et H CN H
CH2CO2Pr-n H CN H
CH2OCH2CH＝CH2 H CN H
CH2OCH2C≡CH H CN H
CH＝CHCO2Me H CN H
CH＝CHCO2Et H CN H
CH＝CHCO2Pr-n H CN H
CH＝CHCN H CN H
PH H CN H
CH2Ph H CN H
SPh H CN H
SO2Ph H CN H
CONHMe H CN H
CONHEt H CN H
CONHPr-n H CN H
CONHPr-i H CN H
CONHBu-n H CN H
CONHBu-sec H CN H
CONHBu-t H CN H
CON(Me)2 H CN H
CON(Et)2 H CN H
CON(Pr-n)2 H CN H
R3 R2 R1 R4
F H Me H
Cl H Me H
Br H Me H
I H Me H
CH＝CH2 H Me H
CH2CH＝CH2 H Me H
C≡CH H Me H
CH2C≡CH H Me H
CH2F H Me H
CHF2 H Me H
CN H Me H
NH2 H Me H
NHCOMe H Me H
CH2NH2 H Me H
CH2NHCOMe H Me H
CH2OCHF2 H Me H
CH2OCF3 H Me H
CF3 H Me H
NO2 H Me H
OMe H Me H
OEt H Me H
OPr-n H Me H
OBu-n H Me H
OPen-n H Me H
SMe H Me H
SEt H Me H
SPr-n H Me H
SBu-n H Me H
SPen-n H Me H
SO2Me H Me H
SO2Et H Me H
SO2Pr-n H Me H
COMe H Me H
COEt H Me H
COPr-n H Me H
CO2H H Me H
CO2Me H Me H
CO2Et H Me H
CO2Pr-n H Me H
CO2Bu-n H Me H
R3 R2 R1 R4
CH2CF3 H Me H
CO2Pen-n H Me H
CH2Cl H Me H
CH2Br H Me H
CH2I H Me H
CH2CN H Me H
CH2OH H Me H
CH2OMe H Me H
CH2OEt H Me H
CH2OPr-n H Me H
CH2SMe H Me H
CH2SEt H Me H
CH2SPr-n H Me H
CH2SO2Me H Me H
CH2SO2Et H Me H
CH2SO2Pr-n H Me H
CH2COMe H Me H
CH2COEt H Me H
CH2COPr-n H Me H
CH2CO2H H Me H
CH2CO2Me H Me H
CH2CO2Et H Me H
CH2CO2Pr-n H Me H
CH2OCH2CH＝CH2 H Me H
CH2OCH2C≡CH H Me H
CH＝CHCO2Me H Me H
CH＝CHCO2Et H Me H
CH＝CHCO2Pr-n H Me H
CH＝CHCN H Me H
Ph H Me H
Ph-2-F H Me H
Ph-3-F H Me H
Ph-4-F H Me H
Ph-2-Cl H Me H
Ph-3-Cl H Me H
Ph-4-Cl H Me H
Ph-2-Br H Me H
Ph-3-Br H Me H
Ph-4-Br H Me H
Ph-2-CF3 H Me H
R3 R2 R1 R4
Ph-4-Me H Me H
Ph-3-CF3 H Me H
Ph-4-CF3 H Me H
Ph-2-Me H Me H
Ph-3-Me H Me H
Ph-2-Et H Me H
Ph-2-OMe H Me H
Ph-3-OMe H Me H
Ph-4-OMe H Me H
Ph-2-OEt H Me H
Ph-2-CO2Me H Me H
Ph-2-CO2Et H Me H
Ph-3-CO2Me H Me H
Ph-4-CO2Me H Me H
CH2Ph H Me H
CH2Ph-2-F H Me H
CH2Ph-3-F H Me H
CH2Ph-4-F H Me H
CH2Ph-2-Cl H Me H
CH2Ph-3-Cl H Me H
CH2Ph-4-Cl H Me H
CH2Ph-2-Br H Me H
CH2Ph-3-Br H Me H
CH2Ph-4-Br H Me H
CH2Ph-2-CF3 H Me H
CH2Ph-3-CF3 H Me H
CH2Ph-4-CF3 H Me H
CH2Ph-2-Me H Me H
CH2Ph-3-Me H Me H
CH2Ph-4-Me H Me H
CH2Ph-2-Et H Me H
CH2Ph-2-OMe H Me H
CH2Ph-3-OMe H Me H
CH2Ph-4-OMe H Me H
CH2Ph-2-OEt H Me H
CH2Ph-2-CO2Me H Me H
CH2Ph-2-CO2Et H Me H
CH2Ph-3-CO2Me H Me H
CH2Ph-4-CO2Me H Me H
OPh H Me H
R3 R2 R1 R4
OPh-3-F H Me H
OPh-2-Cl H Me H
OPh-3-Cl H Me H
OPh-4-Cl H Me H
OPh-2-F H Me H
OPh-4-F H Me H
OPh-2-CF3 H Me H
OPh-3-CF3 H Me H
OPh-4-CF3 H Me H
OPh-2-Me H Me H
OPh-3-Me H Me H
OPh-4-Me H Me H
OPh-2-Et H Me H
OPh-2-OMe H Me H
OPh-3-OMe H Me H
OPh-4-OMe H Me H
OPh-2-OEt H Me H
OPh-2-CO2Me H Me H
OPh-3-CO2Me H Me H
OPh-4-CO2Me H Me H
OPh-2-CO2Et H Me H
SPh H Me H
SPh-2-Cl H Me H
SPh-3-Cl H Me H
SPh-4-Cl H Me H
SPh-2-F H Me H
SPh-3-F H Me H
SPh-4-F H Me H
SPh-2-CF3 H Me H
SPh-3-CF3 H Me H
SPh-4-CF3 H Me H
SPh-2-Me H Me H
SPh-3-Me H Me H
SPh-4-Me H Me H
SPh-2-Et H Me H
SPh-2-OMe H Me H
SPh-3-OMe H Me H
SPh-4-OMe H Me H
SPh-2-OEt H Me H
SPh-2-CO2Me H Me H
R3 R2 R1 R4
SO2Ph-2-Cl H Me H
SPh-3-CO2Me H Me H
SPh-4-CO2Me H Me H
SPh-2-CO2Et H Me H
SO2Ph H Me H
SO2Ph-3-Cl H Me H
SO2Ph-4-Cl H Me H
SO2Ph-2-F H Me H
SO2Ph-3-F H Me H
SO2Ph-4-F H Me H
SO2Ph-2-CF3 H Me H
SO2Ph-3-CF3 H Me H
SO2Ph-4-CF3 H Me H
SO2Ph-2-Me H Me H
SO2Ph-3-Me H Me H
SO2Ph-4-Me H Me H
SO2Ph-2-Et H Me H
SO2Ph-2-OMe H Me H
SO2Ph-3-OMe H Me H
SO2Ph-4-OMe H Me H
SO2Ph-2-OEt H Me H
CH2Ph-2-CO2Me H Me H
CH2Ph-3-CO2Me H Me H
CH2Ph-4-CO2Me H Me H
CH2Ph-2-CO2Et H Me H
CONHMe H Me H
CONHEt H Me H
CONHPr-n H Me H
CONHPr-i H Me H
CONHBu-n H Me H
CONHBu-sec H Me H
CONHBu-t H Me H
CON(Me)2 H Me H
CON(Et)2 H Me H
CON(Pr-n)2 H Me H
R3 R2 R1 R4
F H Et H
Cl H Et H
Br H Et H
I H Et H
CH＝CH2 H Et H
CH2CH＝CH2 H Et H
C≡CH H Et H
CH2C≡CH H Et H
CH2F H Et H
CHF2 H Et H
CN H Et H
NH2 H Et H
NHCOMe H Et H
CH2NH2 H Et H
CH2NHCOMe H Et H
CH2OCHF2 H Et H
CH2OCF3 H Et H
CF3 H Et H
NO2 H Et H
OMe H Et H
OEt H Et H
OPr-n H Et H
OBu-n H Et H
OPen-n H Et H
SMe H Et H
SEt H Et H
SPr-n H Et H
SBu-n H Et H
SPen-n H Et H
SO2Me H Et H
SO2Et H Et H
SO2Pr-n H Et H
COMe H Et H
COEt H Et H
COPr-n H Et H
CO2H H Et H
CO2Me H Et H
CO2Et H Et H
CO2Pr-n H Et H
CO2Bu-n H Et H
R3 R2 R1 R4
CO2Pen-n H Et H
CH2Cl H Et H
CH2Br H Et H
CH2I H Et H
CH2CF3 H Et H
CH2CN H Et H
CH2OH H Et H
CH2OMe H Et H
CH2OEt H Et H
CH2OPr-n H Et H
CH2SMe H Et H
CH2SEt H Et H
CH2SPr-n H Et H
CH2SO2Me H Et H
CH2SO2Et H Et H
CH2SO2Pr-n H Et H
CH2COMe H Et H
CH2COEt H Et H
CH2COPr-n H Et H
CH2CO2H H Et H
CH2CO2Me H Et H
CH2CO2Et H Et H
CH2CO2Pr-n H Et H
CH2OCH2CH＝CH2 H Et H
CH2OCH2C≡CH H Et H
CH＝CHCO2Me H Et H
CH＝CHCO2Et H Et H
CH＝CHCO2Pr-n H Et H
CH＝CHCN H Et H
Ph H Et H
CH2Ph H Et H
OPh H Et H
SPh H Et H
SO2Ph H Et H
CONHMe H Et H
CONHEt H Et H
CONHPr-n H Et H
CONHPr-i H Et H
CONHBu-n H Et H
CONHBu-sec H Et H
R3 R2 R1 R4
CONHBu-t H Et H
CON(Me)2 H Et H
CON(Et)2 H Et H
CON(Pr-n)2 H Et H
F Me H H
Cl Me H H
Br Me H H
I Me H H
CH＝CH2 Me H H
CH2CH＝CH2 Me H H
C≡CH Me H H
CH2C≡CH Me H H
CH2F Me H H
CHF2 Me H H
CN Me H H
NH2 Me H H
NHCOMe Me H H
CH2NH2 Me H H
CH2NHCOMe Me H H
CH2OCHF2 Me H H
CH2OCF3 Me H H
CF3 Me H H
NO2 Me H H
OMe Me H H
OEt Me H H
OPr-n Me H H
OBu-n Me H H
OPen-n Me H H
SMe Me H H
SEt Me H H
SPr-n Me H H
SBu-n Me H H
SPen-n Me H H
SO2Me Me H H
SO2Et Me H H
SO2Pr-n Me H H
COMe Me H H
COEt Me H H
COPr-n Me H H
CO2H Me H H
R3 R2 R1 R4
CO2Me Me H H
CO2Et Me H H
CO2Pr-n Me H H
CO2Bu-n Me H H
CO2Pen-n Me H H
CH2Cl Me H H
CH2Br Me H H
CH2I Me H H
CH2CF3 Me H H
CH2CN Me H H
CH2OH Me H H
CH2OMe Me H H
CH2OEt Me H H
CH2OPr-n Me H H
CH2SMe Me H H
CH2SEt Me H H
CH2SPr-n Me H H
CH2SO2Me Me H H
CH2SO2Et Me H H
CH2SO2Pr-n Me H H
CH2COMe Me H H
CH2COEt Me H H
CH2COPr-n Me H H
CH2CO2H Me H H
CH2CO2Me Me H H
CH2CO2Et Me H H
CH2CO2Pr-n Me H H
CH2OCH2CH＝CH2 Me H H
CH2OCH2C≡CH Me H H
CH＝CHCO2Me Me H H
CH＝CHCO2Et Me H H
CH＝CHCO2Pr-n Me H H
CH＝CHCN Me H H
Ph Me H H
Ph-2-F Me H H
Ph-3-F Me H H
Ph-4-F Me H H
Ph-2-Cl Me H H
Ph-3-Cl Me H H
Ph-4-Cl Me H H
R3 R2 R1 R4
Ph-2-Br Me H H
Ph-3-Br Me H H
Ph-4-Br Me H H
Ph-2-CF3 Me H H
Ph-3-CF3 Me H H
Ph-4-CF3 Me H H
Ph-2-Me Me H H
Ph-3-Me Me H H
Ph-4-Me Me H H
Ph-2-Et Me H H
Ph-2-OMe Me H H
Ph-3-OMe Me H H
Ph-4-OMe Me H H
Ph-2-OEt Me H H
Ph-2-CO2Me Me H H
Ph-2-CO2Et Me H H
Ph-3-CO2Me Me H H
Ph-4-CO2Me Me H H
CH2Ph Me H H
CH2Ph-2-F Me H H
CH2Ph-3-F Me H H
CH2Ph-4-F Me H H
CH2Ph-2-Cl Me H H
CH2Ph-3-Cl Me H H
CH2Ph-4-Cl Me H H
CH2Ph-2-Br Me H H
CH2Ph-3-Br Me H H
CH2Ph-4-Br Me H H
CH2Ph-2-CF3 Me H H
CH2Ph-3-CF3 Me H H
CH2Ph-4-CF3 Me H H
CH2Ph-2-Me Me H H
CH2Ph-3-Me Me H H
CH2Ph-4-Me Me H H
CH2Ph-2-Et Me H H
CH2Ph-2-OMe Me H H
CH2Ph-3-OMe Me H H
CH2Ph-4-OMe Me H H
CH2Ph-2-OEt Me H H
CH2Ph-2-CO2Me Me H H
R3 R2 R1 R4
CH2Ph-2-CO2Et Me H H
CH2Ph-3-CO2Me Me H H
CH2Ph-4-CO2Me Me H H
OPh Me H H
OPh-2-Cl Me H H
OPh-3-Cl Me H H
OPh-4-Cl Me H H
OPh-2-F Me H H
OPh-3-F Me H H
OPh-4-F Me H H
OPh-2-CF3 Me H H
OPh-3-CF3 Me H H
OPh-4-CF3 Me H H
OPh-2-Me Me H H
OPh-3-Me Me H H
OPh-4-Me Me H H
OPh-2-Et Me H H
OPh-2-OMe Me H H
OPh-3-OMe Me H H
OPh-4-OMe Me H H
OPh-2-OEt Me H H
OPh-2-CO2Me Me H H
OPh-3-CO2Me Me H H
OPh-4-CO2Me Me H H
OPh-2-CO2Et Me H H
SPh Me H H
SPh-2-Cl Me H H
SPh-3-Cl Me H H
SPh-4-Cl Me H H
SPh-2-F Me H H
SPh-3-F Me H H
SPh-4-F Me H H
SPh-2-CF3 Me H H
SPh-3-CF3 Me H H
SPh-4-CF3 Me H H
SPh-2-Me Me H H
SPh-3-Me Me H H
SPh-4-Me Me H H
SPh-2-Et Me H H
SPh-2-OMe Me H H
R3 R2 R1 R4
SPh-3-OMe Me H H
SPh-4-OMe Me H H
SPh-2-OEt Me H H
SPh-2-CO2Me Me H H
SPh-3-CO2Me Me H H
SPh-4-CO2Me Me H H
SPh-2-CO2Et Me H H
SO2Ph Me H H
SO2Ph-2-Cl Me H H
SO2Ph-3-Cl Me H H
SO2Ph-4-Cl Me H H
SO2Ph-2-F Me H H
SO2Ph-3-F Me H H
SO2Ph-4-F Me H H
SO2Ph-2-CF3 Me H H
SO2Ph-3-CF3 Me H H
SO2Ph-4-CF3 Me H H
SO2Ph-2-Me Me H H
SO2Ph-3-Me Me H H
SO2Ph-4-Me Me H H
SO2Ph-2-Et Me H H
SO2Ph-2-OMe Me H H
SO2Ph-3-OMe Me H H
SO2Ph-4-OMe Me H H
SO2Ph-2-OEt Me H H
CH2Ph-2-CO2Me Me H H
CH2Ph-3-CO2Me Me H H
CH2Ph-4-CO2Me Me H H
CH2Ph-2-CO2Et Me H H
CONHMe Me H H
CONHEt Me H H
CONHPr-n Me H H
CONHPr-i Me H H
CONHBu-n Me H H
CONHBu-sec Me H H
CONHBu-t Me H H
CON(Me)2 Me H H
CON(Et)2 Me H H
CON(Pr-n)2 Me H H
F Et H H
R3 R2 R1 R4
Cl Et H H
Br Et H H
I Et H H
CH＝CH2 Et H H
CH2CH＝CH2 Et H H
C≡CH Et H H
CH2C≡CH Et H H
CH2F Et H H
CHF2 Et H H
CN Et H H
NH2 Et H H
NHCOMe Et H H
CH2NH2 Et H H
CH2NHCOMe Et H H
CH2OCHF2 Et H H
CH2OCF3 Et H H
CF3 Et H H
NO2 Et H H
OMe Et H H
OEt Et H H
OPr-n Et H H
OBu-n Et H H
OPen-n Et H H
SMe Et H H
SEt Et H H
SPr-n Et H H
SBu-n Et H H
SPen-n Et H H
SO2Me Et H H
SO2Et Et H H
SO2Pr-n Et H H
COMe Et H H
COEt Et H H
COPr-n Et H H
CO2H Et H H
CO2Me Et H H
CO2Et Et H H
CO2Pr-n Et H H
CO2Bu-n Et H H
CO2Pen-n Et H H
R3 R2 R1 R4
CH2Cl Et H H
CH2Br Et H H
CH2I Et H H
CH2CF3 Et H H
CH2CN Et H H
CH2OH Et H H
CH2OMe Et H H
CH2OEt Et H H
CH2OPr-n Et H H
CH2SMe Et H H
CH2SEt Et H H
CH2SPr-n Et H H
CH2SO2Me Et H H
CH2SO2Et Et H H
CH2SO2Pr-n Et H H
CH2COMe Et H H
CH2COEt Et H H
CH2COPr-n Et H H
CH2CO2H Et H H
CH2CO2Me Et H H
CHH2CO2Et Et H H
CH2CO2Pr-n Et H H
CH2OCH2CH＝CH2 Et H H
CH2OCH2C≡CH Et H H
CH＝CHCO2Me Et H H
CH＝CHCO2Et Et H H
CH＝CHCO2Pr-n Et H H
CH＝CHCN Et H H
Ph Et H H
CH2Ph Et H H
OPh Et H H
SPh Et H H
SO2Ph Et H H
CONHMe Et H H
CONHEt Et H H
CONHPr-n Et H H
CONHPr-i Et H H
CONHBu-n Et H H
CONHBu-sec Et H H
CONHBu-t Et H H
R3 R2 R1 R4
CON(Me)2 Et H H
CON(Et)2 Et H H
CON(Pr-n)2 Et H H
F H Pr-n H
Cl H Pr-n H
Br H Pr-n H
I H Pr-n H
CH＝CH2 H Pr-n H
CH2CH＝CH2 H Pr-n H
C≡CH H Pr-n H
CH2C≡CH H Pr-n H
CH2F H Pr-n H
CHF2 H Pr-n H
CN H Pr-n H
NH2 H Pr-n H
NHCOMe H Pr-n H
CH2NH2 H Pr-n H
CH2NHCOMe H Pr-n H
CH2OCHF2 H Pr-n H
CH2OCF3 H Pr-n H
CF3 H Pr-n H
NO2 H Pr-n H
OMe H Pr-n H
OEt H Pr-n H
OPr-n H Pr-n H
OBu-n H Pr-n H
OPen-n H Pr-n H
SMe H Pr-n H
SEt H Pr-n H
SPr-n H Pr-n H
SBu-n H Pr-n H
SPen-n H Pr-n H
SO2Me H Pr-n H
SO2Et H Pr-n H
SO2Pr-n H Pr-n H
COMe H Pr-n H
COEt H Pr-n H
COPr-n H Pr-n H
CO2H H Pr-n H
CO2Me H Pr-n H
R3 R2 R1 R4
CO2Et H Pr-n H
CO2Pr-n H Pr-n H
CO2Bu-n H Pr-n H
CO2Pen-n H Pr-n H
CH2Cl H Pr-n H
CH2Br H Pr-n H
CH2I H Pr-n H
CH2CF3 H Pr-n H
CH2CN H Pr-n H
CH2OH H Pr-n H
CH2OMe H Pr-n H
CH2OEt H Pr-n H
CH2OPr-n H Pr-n H
CH2SMe H Pr-n H
CH2SEt H Pr-n H
CH2SPr-n H Pr-n H
CH2SO2Me H Pr-n H
CH2SO2Et H Pr-n H
CH2SO2Pr-n H Pr-n H
CH2COMe H Pr-n H
CH2COEt H Pr-n H
CH2COPr-n H Pr-n H
CH2CO2H H Pr-n H
CH2CO2Me H Pr-n H
CH2CO2Et H Pr-n H
CH2CO2Pr-n H Pr-n H
CH2OCH2CH＝CH2 H Pr-n H
CH2OCH2C≡CH H Pr-n H
CH＝CHCO2Me H Pr-n H
CH＝CHCO2Et H Pr-n H
CH＝CHCO2Pr-n H Pr-n H
CH＝CHCN H Pr-n H
Ph H Pr-n H
CH2Ph H Pr-n H
OPh H Pr-n H
SPh H Pr-n H
SO2Ph H Pr-n H
CONHMe H Pr-n H
CONHEt H Pr-n H
CONHPr-n H Pr-n H
R3 R2 R1 R4
CONHPr-i H Pr-n H
CONHBu-n H Pr-n H
CONHBu-sec H Pr-n H
CONHBu-t H Pr-n H
CON(Me)2 H Pr-n H
CON(Et)2 H Pr-n H
CON(Pr-n)2 H Pr-n H
F H Cl H
Cl H Cl H
Br H Cl H
I H Cl H
CH＝CH2 H Cl H
CH2CH＝CH2 H Cl H
C≡CH H Cl H
CH2C≡CH H Cl H
CH2F H Cl H
CHF2 H Cl H
CN H Cl H
NH2 H Cl H
NHCOMe H Cl H
CH2NH2 H Cl H
CH2NHCOMe H Cl H
CH2OCHF2 H Cl H
CH2OCF3 H Cl H
CF3 H Cl H
NO2 H Cl H
OMe H Cl H
OEt H Cl H
OPr-n H Cl H
OBu-n H Cl H
OPen-n H Cl H
SMe H Cl H
SEt H Cl H
SPr-n H Cl H
SBu-n H Cl H
SPen-n H Cl H
SO2Me H Cl H
SO2Et H Cl H
SO2Pr-n H Cl H
COMe H Cl H
R3 R2 R1 R4
COEt H Cl H
COPr-n H Cl H
CO2H H Cl H
CO2Me H Cl H
CO2Et H Cl H
CO2Pr-n H Cl H
CO2Bu-n H Cl H
CO2Pen-n H Cl H
CH2Cl H Cl H
CH2Br H Cl H
CH2I H Cl H
CH2CF3 H Cl H
CH2CN H Cl H
CH2OH H Cl H
CH2OMe H Cl H
CH2OEt H Cl H
CH2OPr-n H Cl H
CH2SMe H Cl H
CH2SEt H Cl H
CH2SPr-n H Cl H
CH2SO2Me H Cl H
CH2SO2Et H Cl H
CH2SO2Pr-n H Cl H
CH2COMe H Cl H
CH2COEt H Cl H
CH2COPr-n H Cl H
CH2CO2H H Cl H
CH2CO2Me H Cl H
CH2CO2Et H Cl H
CH2CO2Pr-n H Cl H
CH2OCH2CH＝CH2 H Cl H
CH2OCH2C≡CH H Cl H
CH＝CHCO2Me H Cl H
CH＝CHCO2Et H Cl H
CH＝CHCO2Pr-n H Cl H
CH＝CHCN H Cl H
Ph H Cl H
CH2Ph H Cl H
OPh H Cl H
SPh H Cl H
R3 R2 R1 R4
SO2Ph H Cl H
CONHMe H Cl H
CONHEt H Cl H
CONHPr-n H Cl H
CONHPr-i H Cl H
CONHBu-n H Cl H
CONHBu-sec H Cl H
CONHBu-t H Cl H
CON(Me)2 H Cl H
CON(Et)2 H Cl H
CON(Pr-n)2 H Cl H
F H NO2 H
Cl H NO2 H
Br H NO2 H
I H NO2 H
CH＝CH2 H NO2 H
CH2CH＝CH2 H NO2 H
C≡CH H NO2 H
CH2C≡CH H NO2 H
CH2F H NO2 H
CHF2 H NO2 H
CN H NO2 H
NH2 H NO2 H
NHCOMe H NO2 H
CH2NH2 H NO2 H
CH2NHCOMe H NO2 H
CH2OCHF2 H NO2 H
CH2OCF3 H NO2 H
CF3 H NO2 H
NO2 H NO2 H
OMe H NO2 H
OEt H NO2 H
OPr-n H NO2 H
OBu-n H NO2 H
OPen-n H NO2 H
SMe H NO2 H
SEt H NO2 H
SPr-n H NO2 H
SBu-n H NO2 H
SPen-n H NO2 H
R3 R2 R1 R4
SO2Me H NO2 H
SO2Et H NO2 H
SO2Pr-n H NO2 H
COMe H NO2 H
COEt H NO2 H
COPr-n H NO2 H
CO2H H NO2 H
CO2Me H NO2 H
CO2Et H NO2 H
CO2Pr-n H NO2 H
CO2Bu-n H NO2 H
CO2Pen-n H NO2 H
CH2Cl H NO2 H
CH2Br H NO2 H
CH2I H NO2 H
CH2CF3 H NO2 H
CH2CN H NO2 H
CH2OH H NO2 H
CH2OMe H NO2 H
CH2OEt H NO2 H
CH2OPr-n H NO2 H
CH2SMe H NO2 H
CH2SEt H NO2 H
CH2SPr-n H NO2 H
CH2SO2Me H NO2 H
CH2SO2Et H NO2 H
CH2SO2Pr-n H NO2 H
CH2COMe H NO2 H
CH2COEt H NO2 H
CH2COPr-n H NO2 H
CH2CO2H H NO2 H
CH2CO2Me H NO2 H
CH2CO2Et H NO2 H
CH2CO2Pr-n H NO2 H
CH2OCH2CH＝CH2 H NO2 H
CH2OCH2C≡CH H NO2 H
CH＝CHCO2Me H NO2 H
CH＝CHCO2Et H NO2 H
CH＝CHCO2Pr-n H NO2 H
CH＝CHCN H NO2 H
R3 R2 R1 R4
Ph H NO2 H
CH2Ph H NO2 H
OPh H NO2 H
SPh H NO2 H
SO2Ph H NO2 H
CONHMe H NO2 H
CONHEt H NO2 H
CONHPr-n H NO2 H
CONHPr-i H NO2 H
CONHBu-n H NO2 H
CONHBu-sec H NO2 H
CONHBu-t H NO2 H
CON(Me)2 H NO2 H
CON(Et)2 H NO2 H
CON(Pr-n)2 H NO2 H
F H CF3 H
Cl H CF3 H
Br H CF3 H
I H CF3 H
CH＝CH2 H CF3 H
CH2CH＝CH2 H CF3 H
C≡CH H CF3 H
CH2C≡CH H CF3 H
CH2F H CF3 H
CHF2 H CF3 H
CN H CF3 H
NH2 H CF3 H
NHCOMe H CF3 H
CH2NH2 H CF3 H
CH2NHCOMe H CF3 H
CH2OCHF2 H CF3 H
CH2OCF3 H CF3 H
CF3 H CF3 H
NO2 H CF3 H
OMe H CF3 H
OEt H CF3 H
OPr-n H CF3 H
OBu-n H CF3 H
OPen-n H CF3 H
SMe H CF3 H
R3 R2 R1 R4
SEt H CF3 H
SPr-n H CF3 H
SBu-n H CF3 H
SPen-n H CF3 H
SO2Me H CF3 H
SO2Et H CF3 H
SO2Pr-n H CF3 H
COMe H CF3 H
COEt H CF3 H
COPr-n H CF3 H
CO2H H CF3 H
CO2Me H CF3 H
CO2Et H CF3 H
CO2Pr-n H CF3 H
CO2Bu-n H CF3 H
CO2Pen-n H CF3 H
CH2Cl H CF3 H
CH2Br H CF3 H
CH2I H CF3 H
CH2CF3 H CF3 H
CH2CN H CF3 H
CH2OH H CF3 H
CH2OMe H CF3 H
CH2OEt H CF3 H
CH2OPr-n H CF3 H
CH2SMe H CF3 H
CH2SEt H CF3 H
CH2SPr-n H CF3 H
CH2SO2Me H CF3 H
CH2SO2Et H CF2 H
CH2SO2Pr-n H CF3 H
CH2COMe H CF3 H
CH2COEt H CF3 H
CH2COPr-n H CF3 H
CH2CO2H H CF3 H
CH2CO2Me H CF3 H
CH2CO2Et H CF3 H
CH2CO2Pr-n H CF3 H
CH2OCH2CH＝CH2 H CF3 H
CH2OCH2C≡CH H CF3 H
R3 R2 R1 R4
CH＝CHCO2Me H CF3 H
CH＝CHCO2Et H CF3 H
CH＝CHCO2Pr-n H CF3 H
CH＝CHCN H CF3 H
Ph H CF3 H
CH2Ph H CF3 H
OPh H CF3 H
SPh H CF3 H
SO2Ph H CF3 H
CONHMe H CF3 H
CONHEt H CF3 H
CONHPr-n H CF3 H
CONHPr-i H CF3 H
CONHBu-n H CF3 H
CONHBu-sec H CF3 H
CONHBu-t H CF3 H
CON(Me)2 H CF3 H
CON(Et)2 H CF3 H
CON(Pr-n)2 H CF3 H
R3 R2 R1 R4
F H OMe H
Cl H OMe H
Br H OMe H
I H OMe H
CH＝CH2 H OMe H
CH2CH＝CH2 H OMe H
C≡CH H OMe H
CH2C≡CH H OMe H
CH2F H OMe H
CHF2 H OMe H
CN H OMe H
NH2 H OMe H
NHCOMe H OMe H
CH2NH2 H OMe H
CH2NHCOMe H OMe H
CH2OCHF2 H OMe H
CH2OCF3 H OMe H
CF3 H OMe H
NO2 H OMe H
OMe H OMe H
OEt H OMe H
OPr-n H OMe H
OBu-n H OMe H
OPen-n H OMe H
SMe H OMe H
SEt H OMe H
SPr-n H OMe H
SBu-n H OMe H
SPen-n H OMe H
SO2Me H OMe H
SO2Et H OMe H
SO2Pr-n H OMe H
COMe H OMe H
COEt H OMe H
COPr-n H OMe H
CO2H H OMe H
CO2Me H OMe H
CO2Et H OMe H
CO2Pr-n H OMe H
CO2Bu-n H OMe H
R3 R2 R1 R4
CO2Pen-n H OMe H
CH2Cl H OMe H
CH2Br H OMe H
CH2I H OMe H
CH2CF3 H OMe H
CH2CN H OMe H
CH2OH H OMe H
CH2OMe H OMe H
CH2OEt H OMe H
CH2OPr-n H OMe H
CH2SMe H OMe H
CH2SEt H OMe H
CH2SPr-n H OMe H
CH2SO2Me H OMe H
CH2SO2Et H OMe H
CH2SO2Pr-n H OMe H
CH2COMe H OMe H
CH2COEt H OMe H
CH2COPr-n H OMe H
CH2CO2H H OMe H
CH2CO2Me H OMe H
CH2CO2Et H OMe H
CH2CO2Pr-n H OMe H
CH2OCH2CH＝CH2 H OMe H
CH2OCH2C≡CH H OMe H
CH＝CHCO2Me H OMe H
CH＝CHCO2Pr-n H OMe H
CH＝CHCN H OMe H
Ph H OMe H
CH2Ph H OMe H
OPh H OMe H
SPh H OMe H
SO2Ph H OMe H
CONHMe H OMe H
CONHEt H OMe H
CONHPr-n H OMe H
CONHPr-i H OMe H
CONHBu-n H OMe H
CONHBu-sec H OMe H
R3 R2 R1 R4
CONHBu-t H OMe H
CON(Me)2 H OMe H
CON(Et)2 H OMe H
CON(Pr-n)2 H OMe H
F H OMe H
Cl H OMe H
Br H OMe H
I H OMe H
CH＝CH2 H OMe H
C≡CH H OMe H
CH2C≡CH H OMe H
CH2F H OMe H
CHF2 H OMe H
CN H OMe H
NH2 H OMe H
NHCOMe H OMe H
CH2NH2 H OMe H
CH2NHCOMe H OMe H
CH2OCHF2 H OMe H
CH2OCF3 H OMe H
CF3 H OMe H
NO2 H OMe H
OMe H OMe H
OEt H OMe H
OPr-n H OMe H
OBu-n H OMe H
OPen-n H OMe H
SMe H OMe H
SEt H OMe H
SPr-n H OMe H
SBu-n H OMe H
SPen-n H OMe H
SO2Me H OMe H
SO2Et H OMe H
SO2Pr-n H OMe H
COMe H OMe H
COEt H OMe H
COPr-n H OMe H
CO2H H OMe H
R3 R2 R1 R4
CO2Me H SMe H
CO2Et H SMe H
CO2Pr-n H SMe H
CO2Bu-n H SMe H
CO2Pen-n H SMe H
CH2Cl H SMe H
CH2Br H SMe H
CH2I H SMe H
CH2CF3 H SMe H
CH2CN H SMe H
CH2OH H SMe H
CH2OMe H SMe H
CH2OEt H SMe H
CH2OPr-n H SMe H
CH2SMe H SMe H
CH2SEt H SMe H
CH2SPr-n H SMe H
CH2SO2Me H SMe H
CH2SO2Et H SMe H
CH2SO2Pr-n H SMe H
CH2COMe H SMe H
CH2COEt H SMe H
CH2COPr-n H SMe H
CH2CO2H H SMe H
CH2CO2Me H SMe H
CH2CO2Et H SMe H
CH2CO2Pr-n H SMe H
CH2OCH2CH＝CH2 H SMe H
CH2OCH2C≡CH H SMe H
CH＝CHCO2Me H SMe H
CH＝CHCO2Et H SMe H
CH＝CHCO2Pr-n H SMe H
CH＝CHCN H SMe H
Ph H SMe H
CH2Ph H SMe H
OPh H SMe H
SPh H SMe H
SO2Ph H SMe H
CONHMe H SMe H
CONHEt H SMe H
R3 R2 R1 R4
CONHPr-n H SMe H
CONHPr-i H SMe H
CONHBu-n H SMe H
CONHBu-sec H SMe H
CONHBu-t H SMe H
CON(Me)2 H SMe H
CON(Et)2 H SMe H
CON(Pr-n)2 H SMe H
F H SMe H
Cl H SMe H
Br H SMe H
I H SMe H
CH＝CH2 H SMe H
CH2CH＝CH2 H SMe H
C≡CH H SMe H
CH2C≡CH H SMe H
CH2F H SMe H
CHF2 H SMe H
CN H SMe H
NH2 H SMe H
NHCOMe H SMe H
CH2NH2 H SMe H
CH2NHCOMe H SMe H
CH2OCHF2 H SMe H
CH2OCF3 H SMe H
CF3 H SMe H
NO2 H SMe H
OMe H SMe H
OEt H SMe H
OPr-n H SMe H
OBu-n H SMe H
OPen-n H SMe H
SMe H SMe H
SEt H SMe H
SBu-n H SMe H
SPen-n H SMe H
SO2Me H SMe H
SO2Et H SMe H
SO2Pr-n H SMe H
R3 R2 R1 R4
COMe H SO2Me H
COEt H SO2Me H
COPr-n H SO2Me H
CO2H H SO2Me H
CO2Me H SO2Me H
CO2Et H SO2Me H
CO2Pr-n H SO2Me H
CO2Bu-n H SO2Me H
CO2Pen-n H SO2Me H
CH2Cl H SO2Me H
CH2Br H SO2Me H
CH2I H SO2Me H
CH2CF3 H SO2Me H
CH2CN H SO2Me H
CH2OH H SO2Me H
CH2OMe H SO2Me H
CH2OEt H SO2Me H
CH2OPr-n H SO2Me H
CH2SMe H SO2Me H
CH2SEt H SO2Me H
CH2SPr-n H SO2Me H
CH2SO2Me H SO2Me H
CH2SO2Et H SO2Me H
CH2SO2Pr-n H SO2Me H
CH2COMe H SO2Me H
CH2COEt H SO2Me H
CH2COPr-n H SO2Me H
CH2CO2H H SO2Me H
CH2CO2Me H SO2Me H
CH2CO2Et H SO2Me H
CH2CO2Pr-n H SO2Me H
CH2OCH2CH＝CH2 H SO2Me H
CH2OCH2C≡CH H SO2Me H
CH＝CHCO2Me H SO2Me H
CH＝CHCO2Et H SO2Me H
CH＝CHCO2Pr-n H SO2Me H
CM＝CHCN H SO2Me H
Ph H SO2Me H
CM2Ph H SO2Me H
OPh H SO2Me H
R3 R2 R1 R4
SPh H SO2Me H
SO2Ph H SO2Me H
CONHMe H SO2Me H
CONHEt H SO2Me H
CONHPr-n H SO2Me H
CONHPr-i H SO2Me H
CONHBu-n H SO2Me H
CONHBu-sec H SO2Me H
CONHBu-t H SO2Me H
CON(Me)2 H SO2Me H
CON(Et)2 H SO2Me H
CON(Pr-n)2 H SO2Me H
F H SO2Me H
Cl H SO2Me H
Br H SO2Me H
I H SO2Me H
CH＝CH2 H SO2Me H
CH2CH＝CH2 H SO2Me H
C≡CH H SO2Me H
CH2C≡CH H SO2Me H
CH2F H SO2Me H
CHF2 H SO2Me H
CN H SO2Me H
NH2 H SO2Me H
NHCOMe H SO2Me H
CH2NH2 H SO2Me H
CH2NHCOMe H SO2Me H
CH2OCHF2 H SO2Me H
CH2OCF3 H SO2Me H
CF3 H SO2Me H
NO2 H SO2Me H
OMe H SO2Me H
OEt H SO2Me H
OPr-n H SO2Me H
OBu-n H SO2Me H
OPen-n H SO2Me H
SMe H SO2Me H
SEt H SO2Me H
SPr-n H SO2Me H
SBu-n H SO2Me H
R3 R2 R1 R4
SPen-n H COMe H
SO2Me H COMe H
SO2Et H COMe H
SO2Pr-n H COMe H
COMe H COMe H
COEt H COMe H
COPr-n H COMe H
CO2H H COMe H
CO2Me H COMe H
CO2Et H COMe H
CO2Pr-n H COMe H
CO2Bu-n H COMe H
CO2Pen-n H COMe H
CH2Cl H COMe H
CH2Br H COMe H
CH2I H COMe H
CH2CF3 H COMe H
CH2CN H COMe H
CH2OH H COMe H
CH2OMe H COMe H
CH2OEt H COMe H
CH2OPr-n H COMe H
CH2SMe H COMe H
CH2SEt H COMe H
CH2SPr-n H COMe H
CH2SO2Me H COMe H
CH2SO2Et H COMe H
CH2SO2Pr-n H COMe H
CH2COMe H COMe H
CH2COEt H COMe H
CH2COPr-n H COMe H
CH2CO2N H COMe H
CH2CO2Me H COMe H
CH2CO2Et H COMe H
CH2CO2Pr-n H COMe H
CH2OCH2CH＝CH2 H COMe H
CH2OCH2C≡CH H COMe H
CH＝CHCO2Me H COMe H
CH＝CHCO2Et H COMe H
CH＝CHCO2Pr-n H COMe H
R3 R2 R1 R4
CH＝CHCN H COMe H
Ph H COMe H
CH2Ph H COMe H
OPh H COMe H
SPh H COMe H
SO2Ph H COMe H
CONHMe H COMe H
CONHEt H COMe H
CONHPr-n H COMe H
CONHPr-i H COMe H
CONHBu-n H COMe H
CONHBu-sec H COMe H
CONHBu-t H COMe H
CON(Me)2 H COMe H
CON(Et)2 H COMe H
CON(Pr-n)2 H COMe H
F H CO2Me H
Cl H CO2Me H
Br H CO2Me H
I H CO2Me H
CH＝CH2 H CO2Me H
CH2CH＝CH2 H CO2Me H
C≡CH H CO2Me H
CH2C≡CH H CO2Me H
CH2F H CO2Me H
CHF2 H CO2Me H
CN H CO2Me H
NH2 H CO2Me H
NHCOMe H CO2He H
CH2NH2 H CO2Me H
CH2NHCOMe H CO2Me H
CH2OCHF H CO2Me H
CH2OCF3 H CO2Me H
CF3 H CO2Me H
NO2 H CO2Me H
OMe H CO2Me H
OEt H CO2Me H
OPr-n H CO2Me H
OBu-n H CO2Me H
OPen-n H CO2Me H
R3 R2 R1 R4
SMe H CO2Me H
SEt H CO2Me H
SPr-n H CO2Me H
SBu-n H CO2Me H
SPen-n H CO2Me H
SO2Me H CO2Me H
SO2Et H CO2Me H
SO2Pr-n H CO2Me H
COMe H CO2Me H
COEt H CO2Me H
COPr-n H CO2Me H
CO2H H CO2Me H
CO2Me H CO2Me H
CO2Et H CO2Me H
CO2Pr-n H CO2Me H
CO2Bu-n H CO2Me H
CO2Pen-n H CO2Me H
CH2Cl H CO2Me H
CH2Br H CO2Me H
CH2I H CO2Me H
CH2CF3 H CO2Me H
CH2CN H CO2Me H
CH2OH H CO2Me H
CH2OMe H CO2Me H
CH2OEt H CO2Me H
CH2OPr-n H CO2Me H
CH2SMe H CO2Me H
CH2SEt H CO2Me H
CH2SPr-n H CO2Me H
CH2SO2Me H CO2Me H
CH2SO2Et H CO2Me H
CH2SO2Pr-n H CO2Me H
CH2COMe H CO2Me H
CH2COEt H CO2Me H
CH2COPr-n H CO2Me H
CH2CO2H H CO2Me H
CH2CO2Me H CO2Me H
CH2CO2Et H CO2Me H
CH2CO2Pr-n H CO2Me H
CH2OCH2CH＝CH2 H CO2Me H
R3 R2 R1 R4
CH2OCH2C≡CH H CO2Me H
CH＝CHCO2Me H CO2Me H
CH＝CHCO2Et H CO2Me H
CH＝CHCO2Pr-n H CO2Me H
CH＝CHCN H CO2Me H
Ph H CO2Me H
CH2Ph H CO2Me H
OPh H CO2Me H
SPh H CO2Me H
SO2Ph H CO2Me H
CONHMe H CO2Me H
CONHEt H CO2Me H
CONHPr-n H CO2Me H
CONHPr-i H CO2Me H
CONHBu-n H CO2Me H
CONHBu-sec H CO2Me H
CONHBu-t H CO2Me H
CON(Me)2 H CO2Me H
CON(Et)2 H CO2Me H
CON(Pr-n)2 H CO2Me H
F H CO2H H
Cl H CO2H H
Br H CO2H H
I H CO2H H
CH＝CH2 H CO2H H
CH2CH＝CH2 H CO2H H
C≡CH H CO2H H
CH2C≡CH H CO2H H
CH2F H CO2H H
CHF2 H CO2H H
CN H CO2H H
NH2 H CO2H H
NHCOMe H CO2H H
CH2NH2 H CO2H H
CH2NHCOMe H CO2H H
CH2OCHF2 H CO2H H
CH2OCF3 H CO2H H
CF3 H CO2H H
NO2 H CO2H H
OMe H CO2H H
R3 R2 R1 R4
OEt H CO2H H
OPr-n H CO2H H
OBu-n H CO2H H
OPen-n H CO2H H
SMe H CO2H H
SEt H CO2H H
SPr-n H CO2H H
SBu-n H CO2H H
SPen-n H CO2H H
SO2Me H CO2H H
SO2Et H CO2H H
SO2Pr-n H CO2H H
COMe H CO2H H
COEt H CO2H H
COPr-n H CO2H H
CO2H H CO2H H
CO2Me H CO2H H
CO2Et H CO2H H
CO2Pr-n H CO2H H
CO2Bu-n H CO2H H
CO2Pen-n H CO2H H
CH2Cl H CO2H H
CH2Br H CO2H H
CH2I H CO2H H
CH2CF3 H CO2H H
CH2CN H CO2H H
CH2OH H CO2H H
CH2OMe H CO2H H
CH2OEt H CO2H H
CH2OPr-n H CO2H H
CH2SMe H CO2H H
CH2SEt H CO2H H
CH2SPr-n H CO2H H
CH2SO2Me H CO2H H
CH2SO2Et H CO2H H
CH2SO2Pr-n H CO2H H
CH2COMe H CO2H H
CH2COEt H CO2H H
CH2COPr-n H CO2H H
CH2CO2H H CO2H H
R3 R2 R1 R4
CH2CO2Me H CO2H H
CH2CO2Et H CO2H H
CH2CO2Pr-n H CO2H H
CH2OCH2CH＝CH2 H CO2H H
CH2OCH2C≡CH H CO2H H
CH＝CHCO2Me H CO2H H
CH＝CHCO2Et H CO2H H
CH＝CHCO2Pr-n H CO2H H
CH＝CHCN H CO2H H
Ph H CO2H H
CH2Ph H CO2H H
OPh H CO2H H
SPh H CO2H H
SO2Ph H CO2H H
CONHMe H CO2H H
CONHEt H CO2H H
CONHPr-n H CO2H H
CONHPr-i H CO2H H
CONHBu-n H CO2H H
CONHBu-sec H CO2H H
CONHBu-t H CO2H H
CON(Me)2 H CO2H H
CON(Et)2 H CO2H H
CON(Pr-n)2 H CO2H H
F H CH2F H
Cl H CH2F H
Br H CH2F H
I H CH2F H
C＝CH2 H CH2F H
CH2CH＝CH2 H CH2F H
C≡CH H CH2F H
CH2C≡CH H CH2F H
CH2F H CH2F H
CHF2 H CH2F H
CN H CH2F H
NH2 H CH2F H
NHCOMe H CH2F H
CH2NH2 H CH2F H
CH2NHCOMe H CH2F H
CH2OCHF2 H CH2F H
R3 R2 R1 R4
CH2OCF3 H CH2F H
CF3 H CH2F H
NO2 H CH2F H
OMe H CH2F H
OEt H CH2F H
OPr-n H CH2F H
OBu-n H CH2F H
OPen-n H CH2F H
SMe H CH2F H
SEt H CH2F H
SPr-n H CH2F H
SBu-n H CH2F H
SPen-n H CH2F H
SO2Me H CH2F H
SO2Et H CH2F H
SO2Pr-n H CH2F H
COMe H CH2F H
COEt H CH2F H
COPr-n H CH2F H
CO2H H OH2F H
CO2Me H CH2F H
CO2Et H CH2F H
CO2Pr-n H CH2F H
CO2Bu-n H CH2F H
CO2Pen-n H CH2F H
CH2Cl H CH2F H
CH2Br H CH2F H
CH2I H CH2F H
CH2CF3 H CH2F H
CH2CN H CH2F H
CH2OH H CH2F H
CH2OMe H CH2F H
CH2OEt H CH2F H
CH2OPr-n H CH2F H
CH2SMe H CH2F H
CH2SEt H CH2F H
CH2SPr-n H CH2F H
CH2SO2Me H CH2F H
CH2SO2Et H CH2F H
CH2SO2Pr-n H CH2F H
R3 R2 R1 R4
CH2COMe H CH2F H
CH2COEt H CH2F H
CH2COPr-n H CH2F H
CH2CO2H H CH2F H
CH2CO2Me H CH2F H
CH2CO2Et H CH2F H
CH2CO2Pr-n H CH2F H
CH2OCH2CH＝CH2 H CH2F H
CH2OCH2C≡CH H CH2F H
CH＝CHCO2Me H CH2F H
CH＝CHCO2Et H CH2F H
CH＝CHCO2Pr-n H CH2F H
CH＝CHCN H CH2F H
Ph H CH2F H
CH2Ph H CH2F H
OPh H CH2F H
SPh H CH2F H
SO2Ph H CH2F H
CONHMe H CH2F H
CONHEt H CH2F H
CONHPr-n H CH2F H
CONHPr-i H CH2F H
CONHBu-n H CH2F H
CONHBu-sec H CH2F H
CONHBu-t H CH2F H
CON(Me)2 H CH2F H
CON(Et)2 H CH2F H
CON(Pr-n)2 H CH2F H
F H CH2Cl H
Cl H CH2Cl H
Br H CH2Cl H
I H CH2Cl H
CH＝CH2 H CH2Cl H
CH2CH＝CH2 H CH2Cl H
C≡CH H CH2Cl H
CH2C≡CH H CH2Cl H
CH2F H CH2Cl H
CHF2 H CH2Cl H
CN H CH2Cl H
NH2 H CH2Cl H
R3 R2 R1 R4
NHCOMe H CH2Cl H
CH2NH2 H CH2Cl H
CH2NHCOMe H CH2Cl H
CH2OCHF2 H CH2Cl H
CH2OCF3 H CH2Cl H
CF3 H CH2Cl H
NO2 H CH2Cl H
OMe H CH2Cl H
OEt H CH2Cl H
OPr-n H CH2Cl H
OBu-n H CH2Cl H
OPen-n H CH2Cl H
SMe H CH2Cl H
SEt H CH2Cl H
SPr-n H CH2Cl H
SBu-n H CH2Cl H
SPen-n H CH2Cl H
SO2Me H CH2Cl H
SO2Et H CH2Cl H
SO2Pr-n H CH2Cl H
COMe H CH2Cl H
COEt H CH2Cl H
COPr-n H CH2Cl H
CO2H H CH2Cl H
CO2Me H CH2Cl H
CO2Et H CH2Cl H
CO2Pr-n H CH2Cl H
CO2Bu-n H CH2Cl H
CO2Pen-n H CH2Cl H
CH2Cl H CH2Cl H
CH2Br H CH2Cl H
CH2I H CH2Cl H
CH2CF3 H CH2Cl H
CH2CN H CH2Cl H
CH2ON H CH2Cl H
CH2OMe H CH2Cl H
CH2OEt H CH2Cl H
CH2OPr-n H CH2Cl H
CH2SMe H CH2Cl H
CH2SEt H CH2Cl H
R3 R2 R1 R4
CH2SPr-n H CH2Cl H
CH2SO2Me H CH2Cl H
CH2SO2Et H CH2Cl H
CH2SO2Pr-n H CH2Cl H
CH2COMe H CH2Cl H
CH2COEt H CH2Cl H
CH2COPr-n H CH2Cl H
CH2CO2H H CH2Cl H
CH2CO2Me H CH2Cl H
CH2CO2Et H CH2Cl H
CH2CO2Pr-n H CH2Cl H
CH2OCH2CH＝CH2 H CH2Cl H
CH2OCH2C≡CH H CH2Cl H
CH＝CHCO2Me H CH2Cl H
CH＝CHCO2Et H CH2Cl H
CH＝CHCO2Pr-n H CH2Cl H
CH＝CHCN H CH2Cl H
Ph H CH2Cl H
CH2Ph H CH2Cl H
OPh H CH2Cl H
SPh H CH2Cl H
SO2Ph H CH2Cl H
CONHMe H CH2Cl H
CONHEt H CH2Cl H
CONHPr-n H CH2Cl H
CONHPr-i H CH2Cl H
CONHBu-n H CH2Cl H
CONHBu-sec H CH2Cl H
CONHBu-t H CH2Cl H
CON(Me)2 H CH2Cl H
CON(Et)2 H CH2Cl H
CON(Pr-n) H CH2Cl H
F H CH2OMe H
Cl H CH2OMe H
Br H CH2OMe H
I H CH2OMe H
CH＝CH2 H CH2OMe H
CH2CH＝CH2 H CH2OMe H
C≡CH H CH2OMe H
CH2C≡CH H CH2OMe H
R3 R2 R1 R4
CH2F H CH2OMe H
CHF2 H CH2OMe H
CN H CH2OMe H
NH2 H CH2OMe H
NHCOMe H CH2OMe H
CH2NH2 H CH2OHe H
CH2NHCOMe H CH2OMe H
CH2OCHF2 H CH2OMe H
CH2OCF3 H CH2OMe H
CF3 H CH2OMe H
NO2 H CH2OMe H
OMe H CH2OMe H
OEt H CH2OMe H
OPr-n H CH2OMe H
OBu-n H CH2OMe H
OPen-n H CH2OMe H
SMe H CH2OMe H
SEt H CH2OMe H
SPr-n H CH2OMe H
SBu-n H CH2OMe H
SPen-n H CH2OMe H
SO2Me H CH2OMe H
SO2Et H CH2OMe H
SO2Pr-n H CH2OMe H
COMe H CH2OMe H
COEt H CH2OMe H
COPr-n H CH2OMe H
CO2H H CH2OMe H
CO2Me H CH2OMe H
CO2Et H CH2OMe H
CO2Pr-n H CH2OMe H
CO2Bu-n H CH2OMe H
CO2Pen-n H CH2OMe H
CH2Cl H CH2OMe H
CH2Br H CH2OMe H
CH2I H CH2OMe H
CH2CF3 H CH2OMe H
CH2CN H CH2OMe H
CH2OH H CH2OMe H
CH2OMe H CH2OMe H
R3 R2 R1 R4
CH2OEt H CH2OMe H
CH2OPr-n H CH2OMe H
CH2SMe H CH2OMe H
CH2SEt H CH2OMe H
CH2SPr-n H CH2OMe H
CH2SO2Me H CH2OMe H
CH2SO2Et H CH2OMe H
CH2SO2Pr-n H CH2OMe H
CH2COMe H CH2OMe H
CH2COEt H CH2OMe H
CH2COPr-n H CH2OMe H
CH2CO2H H CH2OMe H
CH2CO2Me H CH2OMe H
CH2CO2Et H CH2OMe H
CH2CO2Pr-n H CH2OMe H
CH2OCH2CH＝CH2 H CH2OMe H
CH2OCH2C≡CH H CH2OMe H
CH＝CHCO2Me H CH2OMe H
CH＝CHCO2Et H CH2OMe H
CH＝CHCO2Pr-n H CH2OMe H
CH＝CHCN H CH2OMe H
Ph H CH2OMe H
CH2Ph H CH2OMe H
OPh H CH2OMe H
SPh H CH2OMe H
SO2Ph H CH2OMe H
CONHMe H CH2OMe H
COMHEt H CH2OMe H
CONHPr-n H CH2OMe H
CONHPr-i H CH2OMe H
CONHBu-n H CH2OMe H
CONHBu-sec H CH2OMe H
CONHBu-t H CH2OMe H
CON(Me)2 H CH2OMe H
CON(Et)2 H CH2OMe H
CON(Pr-n)2 H CH2OMe H
F H CH2SMe H
Cl H CH2SMe H
Br H CH2SMe H
I H CH2SMe H
R3 R2 R1 R4
CH＝CH2 H CH2SMe H
CH2CH＝CH2 H CH2SMe H
C≡CH H CH2SMe H
CH2C≡CH H CH2SMe H
CH2F H CH2SMe H
CHF2 H CH2SMe H
CN H CH2SMe H
NH2 H CH2SMe H
NHCOMe H CH2SMe H
CH2NH2 H CH2SMe H
CH2NHCOMe H CH2SMe H
CH2OCHF2 H CH2SMe H
CH2OCF3 H CH2SMe H
CF3 H CH2SMe H
NO2 H CH2SMe H
OMe H CH2SMe H
OEt H CH2SMe H
OPr-n H CH2SMe H
OBu-n H CH2SMe H
OPen-n H CH2SMe H
SMe H CH2SMe H
SEt H CH2SMe H
SPr-n H CH2SMe H
SBu-n H CH2SMe H
SPen-n H CH2SMe H
SO2Me H CH2SMe H
SO2Et H CH2SMe H
SO2Pr-n H CH2SMe H
COMe H CH2SMe H
COEt H CH2SMe H
COPr-n H CH2SMe H
CO2H H CH2SMe H
CO2Me H CH2SMe H
CO2Et H CH2SMe H
CO2Pr-n H CH2SMe H
CO2Bu-n H CH2SMe H
CO2Pen-n H CH2SMe H
CH2Cl H CH2SMe H
CH2Br H CH2SMe H
CH2I H CH2SMe H
R3 R2 R1 R4
CH2CF3 H CH2SMe H
CH2CN H CH2SMe H
CH2OH H CH2SMe H
CH2OMe H CH2SMe H
CH2OEt H CH2SMe H
CH2OPr-n H CH2SMe H
CH2SMe H CH2SMe H
CH2SEt H CH2SMe H
CH2SPr-n H CH2SMe H
CH2SO2Me H CH2SMe H
CH2SO2Et H CH2SMe H
CH2SO2Pr-n H CH2SMe H
CH2COMe H CH2SMe H
CH2COEt H CH2SMe H
CH2COPr-n H CH2SMe H
CH2CO2H H CH2SMe H
CH2CO2Me H CH2SMe H
CH2CO2Et H CH2SMe H
CH2CO2Pr-n H CH2SMe H
CH2OCH2CH＝CH2 H CH2SMe H
CH2OCH2C≡CH H CH2SMe H
CH＝CHCO2Me H CH2SMe H
CH＝CHCO2Et H CH2SMe H
CH＝CHCO2Pr-n H CH2SMe H
CH＝CHCN H CH2SMe H
Ph H CH2SMe H
CH2Ph H CH2SMe H
OPh H CH2SMe H
SPh H CH2SMe H
SO2Ph H CH2SMe H
CONHMe H CH2SMe H
CONHEt H CH2SMe H
CONHPr-n H CH2SMe H
CONHPr-i H CH2SMe H
CONHBu-n H CH2SMe H
CONHBu-sec H CH2SMe H
CONHBu-t H CH2SMe H
CON(Me)2 H CH2SMe H
CON(Et)2 H CH2SMe H
CON(Pr-n)2 H CH2SMe H
R3 R2 R1 R4
F H CH2SO2Me H
Cl H CH2SO2Me H
Br H CH2SO2Me H
I H CH2SO2Me H
CH＝CH2 H CH2SO2Me H
CH2CH＝CH2 H CH2SO2Me H
C≡CH H CH2SO2Me H
CH2C≡CH H CH2SO2Me H
CH2F H CH2SO2Me H
CHF2 H CH2SO2Me H
CN H CH2SO2Me H
NH2 H CH2SO2Me H
NHCOMe H CH2SO2Me H
CH2NH2 H CH2SO2Me H
CH2NHCOMe H CH2SO2Me H
CH2OCHF2 H CH2SO2Me H
CH2OCF3 H CH2SO2Me H
CF3 H CH2SO2Me H
NO2 H CH2SO2Me H
OMe H CH2SO2Me H
OEt H CH2SO2Me H
OPr-n H CH2SO2Me H
OBu-n H CH2SO2Me H
OPen-n H CH2SO2Me H
SMe H CH2SO2Me H
SEt H CH2SO2Me H
SPr-n H CH2SO2Me H
SBu-n H CH2SO2Me H
SPen-n H CH2SO2Me H
SO2Me H CH2SO2Me H
SO2Et H CH2SO2Me H
SO2Pr-n H CH2SO2Me H
COMe H CH2SO2Me H
COEt H CH2SO2Me H
COPr-n H CH2SO2Me H
CO2H H CH2SO2Me H
CO2Me H CH2SO2Me H
CO2Et H CH2SO2Me H
CO2Pr-n H CH2SO2Me H
CO2Bu-n H CH2SO2Me H
R3 R2 R1 R4
CO2Pen-n H CH2SO2Me H
CH2Cl H CH2SO2Me H
CH2Br H CH2SO2Me H
CH2I H CH2SO2Me H
CH2CF3 H CH2SO2Me H
CH2CN H CH2SO2Me H
CH2OH H CH2SO2Me H
CH2OMe H CH2SO2Me H
CH2OEt H CH2SO2Me H
CH2OPr H CH2SO2Me H
CH2SMe H CH2SO2Me H
CH2SEt H CH2SO2Me H
CH2SPr-n H CH2SO2Me H
CH2SO2Me H CH2SO2Me H
CH2SO2Et H CH2SO2Me H
CH2SO2Pr-n H CH2SO2Me H
CH2COMe H CH2SO2Me H
CH2COEt H CH2SO2Me H
CH2COPr-n H CH2SO2Me H
CH2CO2H H CH2SO2Me H
CH2CO2Me H CH2SO2Me H
CH2CO2Et H CH2SO2Me H
CH2CO2Pr-n H CH2SO2Me H
CH2OCH2CH＝CH2 H CH2SO2Me H
CH2OCH2C≡CH H CH2SO2Me H
CH＝CHCO2Me H CH2SO2Me H
CH＝CHCO2Et H CH2SO2Me H
CH＝CHCO2Pr-n H CH2SO2Me H
CH＝CHCN H CH2SO2Me H
Ph H CH2SO2Me H
CH2Ph H CH2SO2Me H
OPh H CH2SO2Me H
SPh H CH2SO2Me H
SO2Ph H CH2SO2Me H
COMHMe H CH2SO2Me H
COMHEt H CH2SO2Me H
CONHPr-n H CH2SO2Me H
COMHPr-i H CH2SO2Me H
CONHBu-n H CH2SO2Me H
COMHBu-sec H CH2SO2Me H
R3 R2 R1 R4
CONHBu-t H CH2SO2Me H
CON(Me)2 H CH2SO2Me H
CON(Et)2 H CH2SO2Me H
CON(Pr-n)2 H CH2SO2Me H
F H CH2CO2Me H
Cl H CH2CO2Me H
Br H CH2CO2Me H
I H CH2CO2Me H
CH＝CH2 H CH2CO2Me H
CH2CH＝CH2 H CH2CO2Me H
C≡CH H CH2CO2Me H
CH2C≡CH H CH2CO2Me H
CH2F H CH2CO2Me H
CHF2 H CH2CO2Me H
CN H CH2CO2Me H
NH2 H CH2CO2Me H
NHCOMe H CH2CO2Me H
CH2NH2 H CH2CO2Me H
CH2NHCOMe H CH2CO2Me H
CH2OCHF2 H CH2CO2Me H
CH2OCF3 H CH2CO2Me H
CF3 H CH2CO2Me H
NO2 H CH2CO2Me H
OMe H CH2CO2Me H
OEt H CH2CO2Me H
OPr-n H CH2CO2Me H
OBu-n H CH2CO2Me H
OPen-n H CH2CO2Me H
SMe H CH2CO2Me H
SEt H CH2CO2Me H
SPr-n H CH2CO2Me H
SBu-n H CH2CO2Me H
SPen-n H CH2CO2Me H
SO2Me H CH2CO2Me H
SO2Et H CH2CO2Me H
SO2Pr-n H CH2CO2Me H
COMe H CH2CO2Me H
COEt H CH2CO2Me H
COPr-n H CH2CO2Me H
CO2H H CH2CO2Me H
R3 R2 R1 R4
CO2Me H CH2CO2Me H
CO2Et H CH2CO2Me H
CO2Pr-n H CH2CO2Me H
CO2Bu-n H CH2CO2Me H
CO2Pen-n H CH2CO2Me H
CH2Cl H CH2CO2Me H
CH2Br H CH2CO2Me H
CH2I H CH2CO2Me H
CH2CF3 H CH2CO2Me H
CH2CN H CH2CO2Me H
CH2OH H CH2CO2Me H
CH2OMe H CH2CO2Me H
CH2OEt H CH2CO2Me H
CH2OPr-n H CH2CO2Me H
CH2SMe H CH2CO2Me H
CH2SEt H CH2CO2Me H
CH2SPr-n H CH2CO2Me H
CH2SO2Me H CH2CO2Me H
CH2SO2Et H CH2CO2Me H
CH2SO2Pr-n H CH2CO2Me H
CH2COMe H CH2CO2Me H
CH2COEt H CH2CO2Me H
CH2COPr-n H CH2CO2Me H
CH2CO2n H CH2CO2Me H
CH2CO2Me H CH2CO2Me H
CH2CO2Et H CH2CO2Me H
CH2CO2Pr-n H CH2CO2Me H
CH2OCH2CH＝CH2 H CH2CO2Me H
CH2OCH2C≡CH H CH2CO2Me H
CH＝CHCO2Me H CH2CO2Me H
CH＝CHCO2Et H CH2CO2Me H
CH＝CHCO2Pr-n H CH2CO2Me H
CH＝CHCN H CH2CO2Me H
Ph H CH2CO2Me H
CH2Ph H CH2CO2Me H
OPh H CH2CO2Me H
SPh H CH2CO2Me H
SO2Ph H CH2CO2Me H
CONHMe H CH2CO2Me H
CONHEt H CH2CO2Me H
R3 R2 R1 R4
CONHPr-n H CH2CO2Me H
CONHPr-i H CH2CO2Me H
CONHBu-n H CH2CO2Me H
CONHBu-sec H CH2CO2Me H
CONHBu-t H CH2CO2Me H
CON(Me)2 H CH2CO2Me H
CON(Et)2 H CH2CO2Me H
CON(Pr-n)2 H CH2CO2Me H
F H Ph H
Cl H Ph H
Br H Ph H
I H Ph H
CH＝CH2 H Ph H
CH2CH＝CH2 H Ph H
C≡CH H Ph H
CH2C≡CH H Ph H
CH2F H Ph H
CHF2 H Ph H
CN H Ph H
NH2 H Ph H
NHCOMe H Ph H
CH2NH2 H Ph H
CH2NHCOMe H Ph H
CH2OCHF2 H Ph H
CH2OCF3 H Ph H
CF3 H Ph H
NO2 H Ph H
OMe H Ph H
OEt H Ph H
OPr-n H Ph H
OBu-n H Ph H
OPen-n H Ph H
SMe H Ph H
SEt H Ph H
SPr-n H Ph H
SBu-n H Ph H
SPen-n H Ph H
SO2Me H Ph H
SO2Et H Ph H
SO2Pr-n H Ph H
R3 R2 R1 R4
COMe H Ph H
COEt H Ph H
COPr-n H Ph H
CO2H H Ph H
CO2Me H Ph H
CO2Et H Ph H
CO2Pr-n H Ph H
CO2Bu-n H Ph H
CO2Pen-n H Ph H
CH2Cl H Ph H
CH2Br H Ph H
CH2I H Ph H
CH2CF3 H Ph H
CH2CN H Ph H
CH2OH H Ph H
CH2OMe H Ph H
CH2OEt H Ph H
CH2OPr-n H Ph H
CH2SMe H Ph H
CH2SEt H Ph H
CH2SPr-n H Ph H
CH2SO2Me H Ph H
CH2SO2Et H Ph H
CH2SO2Pr-n H Ph H
CH2COMe H Ph H
CH2COEt H Ph H
CH2COPr-n H Ph H
CH2CO2H H Ph H
CH2CO2Me H Ph H
CH2CO2Et H Ph H
CH2CO2Pr-n H Ph H
CH2OCH2CH＝CH2 H Ph H
CH2OCH2C≡CH H Ph H
CH＝CHCO2Me H Ph H
CH＝CHCO2Et H Ph H
CH＝CHCO2Pr-n H Ph H
CH＝CHCN H Ph H
Ph H Ph H
CH2Ph H Ph H
OPh H Ph HR3 R2 R1 R4SPh H Ph HSO2Ph H Ph HCONHMe H Ph HCONHEt H Ph HCONHPr-n H Ph HCONHPr-i H Ph HCONHBu-n H Ph HCONHBu-sec H Ph HCONHBu-t H Ph HCON(Me)2 H Ph HCON(Et)2 H Ph HCON(Pr-n)2 H Ph HF H CH2Ph HCl H CH2Ph HBr H CH2Ph HI H CH2Ph HCH＝CH2 H CH2Ph HCH2CH＝CH2 H CH2Ph HC≡CH H CH2Ph HCH2C≡CH H CH2Ph HCH2F H CH2Ph HCHF2 H CH2Ph HCN H CH2Ph HNH2 H CH2Ph HNHCOMe H CH2Ph HCH2NH2 H CH2Ph HCH2NHCOMe H CH2Ph HCH2OCMF2 H CH2Ph HCH2OCF3 H CH2Ph HCF3 H CH2Ph HNO2 H CH2Ph HOMe H CH2Ph HOEt H CH2Ph HOPr-n H CH2Ph HOBu-n H CH2Ph HOPen-n H CH2Ph HSMe H CH2Ph HSEt H CH2Ph HSPr-n H CH2Ph HSBu-n H CH2Ph HR3 R2 R1 R4SPen-n H CH2Ph HSO2Me H CH2Ph HSO2Et H CH2Ph HSO2Pr-n H CH2Ph HCOMe H CH2Ph HCOEt H CH2Ph HCOPr-n H CH2Ph HCO2H H CH2Ph HCO2Me H CH2Ph HCO2Et H CH2Ph HCO2Pr-n H CH2Ph HCO2Bu-n H CH2Ph HCO2Pen-n H CH2Ph HCH2Cl H CH2Ph HCH2Br H CH2Ph HCH2I H CH2Ph HCH2CF3 H CH2Ph HCH2CN H CH2Ph HCH2OH H CH2Ph HCH2OMe H CH2Ph HCH2OEt H CH2Ph HCH2OPr-n H CH2Ph HCH2SMe H CH2Ph HCH2SEt H CH2Ph HCH2SPr-n H CH2Ph HCH2SO2Me H CH2Ph HCH2SO2Et H CH2Ph HCH2SO2Pr-n H CH2Ph HCH2COMe H CH2Ph HCH2COEt H CH2Ph HCH2COPr H CH2Ph HCH2CO2H H CH2Ph HCH2CO2Me H CH2Ph HCH2CO2Et H CH2Ph HCH2CO2Pr-n H CH2Ph HCH2OCH2CH＝CH2 H CH2Ph HCH2OCH2C≡CH H CH2Ph HCH＝CHCO2Me H CH2Ph HCH＝CHCO2Et H CH2Ph HCH＝CHCO2Pr-n H CH2Ph HR3 R2 R1 R4CH＝CHCN H CH2Ph HPh H CH2Ph HCH2Ph H CH2Ph HOPh H CH2Ph HSPh H CH2Ph HSO2Ph H CH2Ph HCONHMe H CH2Ph HCONHEt H CH2Ph HCONHPr-n H CH2Ph HCONHPr-i H CH2Ph HCONHBu-n H CH2Ph HCONHBu-sec H CH2Ph HCONHBu-t H CH2Ph HCON(Me)2 H CH2Ph HCON(Et)2 H CH2Ph HCON(Pr-n)2 H CH2Ph HF H OPh HCl H OPh HBr H OPh HI H OPh HCH＝CH2 H OPh HCH2CH＝CH2 H OPh HC≡CH H OPh HCH2C≡CH H OPh HCH2F H OPh HCHF2 H OPh HCN H OPh HNH2 H OPh HNHCOMe H OPh HCH2NH2 H OPh HCH2NHCOMe H OPh HCH2OCHF2 H OPh HCH2OCF3 H OPh HCF3 H OPh HNO2 H OPh HOMe H OPh HOEt H OPh HOPr-n H OPh HOBu-n H OPh HOPen-n H OPh HR3 R2 R1 R4SMe H OPh HSEt H OPh HSPr-n H OPh HSBu-n H OPh HSPen-n H OPh HSO2Me H OPh HSO2Et H OPh HSO2Pr-n H OPh HCOMe H OPh HCOEt H OPh HCOPr-n H OPh HCO2H H OPh HCO2Me H OPh HCO2Et H OPh HCO2Pr-n H OPh HCO2Bu-n H OPh HCO2Pen-n H OPh HCH2Cl H OPh HCH2Br H OPh HCH2I H OPh HCH2CF3 H OPh HCH2CN H OPh HCH2OH H OPh HCH2OMe H OPh HCH2OEt H OPh HCH2OPr-n H OPh HCH2SMe H OPh HCH2SEt H OPh HCH2SPr-n H OPh HCH2SO2Me H OPh HCH2SO2Et H OPh HCH2SO2Pr-n H OPh HCH2COMe H OPh HCH2COEt H OPh HCH2COPr-n H OPh HCH2CO2H H OPh HCH2CO2Me H OPh HCH2CO2Et H OPh HCH2CO2Pr-n H OPh HCH2OCH2CH＝CH2 H OPh HR3 R2 R1 R4CH2OCH2C≡CH H OPh HCH＝CHCO2Me H OPh HCH＝CHCO2Et H OPh HCH＝CHCO2Pr-n H OPh HCH＝CHCN H OPh HPh H OPh HCH2Ph H OPh HOPh H OPh HSPh H OPh HSO2Ph H OPh HCONHMe H OPh HCONHEt H OPh HCONHPr-n H OPh HCONHPr-i H OPh HCONHBu-n H OPh HCONHBu-sec H OPh HCONHBu-t H OPh HCON(Me)2 H OPh HCON(Et)2 H OPh HCON(Pr-n) H OPh HF H SPh HCl H SPh HBr H SPh HI H SPh HCH＝CH2 H SPh HCH2CH＝CH2 H SPh HC≡CH H SPh HCH2C≡CH H SPh HCH2F H SPh HCHF2 H SPh HCN H SPh HNH2 H SPh HNHCOMe H SPh HCH2NH2 H SPh HCH2NHCOMe H SPh HCH2OCHF2 H SPh HCH2OCF3 H SPh HCF3 H SPh HNO2 H SPh HOMe H SPh HR3 R2 R1 R4OEt H SPh HOPr-n H SPh HOBu-n H SPh HOPen-n H SPh HSMe H SPh HSEt H SPh HSPr-n H SPh HSBu-n H SPh HSPen-n H SPh HSO2Me H SPh HSO2Et H SPh HSO2Pr-n H SPh HCOMe H SPh HCOEt H SPh HCOPr-n H SPh HCO2H H SPh HCO2Me H SPh HCO2Et H SPh HCO2Pr-n H SPh HCO2Bu-n H SPh HCO2Pen-n H SPh HCH2Cl H SPh HCH2Br H SPh HCH2I H SPh HCH2CF3 H SPh HCH2CN H SPh HCH2OH H SPh HCH2OMe H SPh HCH2OEt H SPh HCH2OPr-n H SPh HCH2SMe H SPh HCH2SEt H SPh HCH2SPr-n H SPh HCH2SO2Me H SPh HCH2SO2Et H SPh HCH2SO2Pr-n H SPh HCH2COMe H SPh HCH2COEt H SPh HCH2COPr-n H SPh HCH2CO2H H SPh HR3 R2 R1 R4CH2CO2Me H SPh HCH2CO2Et H SPh HCH2CO2Pr-n H SPh HCH2OCH2CH＝CH2 H SPh HCH2OCH2C≡CH H SPh HCH＝CHCO2Me H SPh HCH＝CHCO2Et H SPh HCH＝CHCO2Pr-n H SPh HCH＝CHCN H SPh HPh H SPh HCH2Ph H SPh HOPh H SPh HSPh H SPh HSO2Ph H SPh HCONHMe H SPh HCONHEt H SPh HCONHPr-n H SPh HCONHPr-i H SPh HCONHBu-n H SPh HCONHBu-sec H SPh HC0NHBu-t H SPh HCON(Me)2 H SPh HCON(Et)2 H SPh HCON(Pr-n)2 H SPh HF H SO2Ph HCl H SO2Ph HBr H SO2Ph HI H SO2Ph HCH＝CH2 H SO2Ph HCH2CH＝CH2 H SO2Ph HC≡CH H SO2Ph HCH2C≡CH H SO2Ph HCH2F H SO2Ph HCHF2 H SO2Ph HCN H SO2Ph HNH2 H SO2Ph HNHCOMe H SO2Ph HCH2NH2 H SO2Ph HCH2NHCOMe H SO2Ph HCH2OCHF2 H SO2Ph HR3 R2 R1 R4CH2OCF3 H SO2Ph HCF3 H SO2Ph HNO2 H SO2Ph HOMe H SO2Ph HOEt H SO2Ph HOPr-n H SO2Ph HOBu-n H SO2Ph HOPen-n H SO2Ph HSMe H SO2Ph HSEt H SO2Ph HSPr-n H SO2Ph HSBu-n H SO2Ph HSPen-n H SO2Ph HSO2Me H SO2Ph HSO2Et H SO2Ph HSO2Pr-n H SO2Ph HCOMe H SO2Ph HCOEt H SO2Ph HCOPr-n H SO2Ph HCO2H H SO2Ph HCO2Me H SO2Ph HCO2Et H SO2Ph HCO2Pr-n H SO2Ph HCO2Bu-n H SO2Ph HCO2Pen-n H SO2Ph HCH2Cl H SO2Ph HCH2Br H SO2Ph HCH2I H SO2Ph HCH2CF3 H SO2Ph HCH2CN H SO2Ph HCH2OH H SO2Ph HCH2OMe H SO2Ph HCH2OEt H SO2Ph HCH2OPr-n H SO2Ph HCH2SMe H SO2Ph HCH2SEt H SO2Ph HCH2SPr-n H SO2Ph HCH2SO2Me H SO2Ph HCH2SO2Et H SO2Ph HCH2SO2Pr-n H SO2Ph HR3 R2 R1 R4CH2COMe H SO2Ph HCH2COEt H SO2Ph HCH2COPr-n H SO2Ph HCH2CO2H H SO2Ph HCH2CO2Me H SO2Ph HCH2CO2Et H SO2Ph HCH2CO2Pr-n H SO2Ph HCH2OCH2CH＝CH2 H SO2Ph HCH2OCH2C≡CH H SO2Ph HCH＝CHCO2Me H SO2Ph HCH＝CHCO2Et H SO2Ph HCH＝CHCO2Pr-n H SO2Ph HCH＝CHCN H SO2Ph HPh H SO2Ph HCH2Ph H SO2Ph HOPh H SO2Ph HSPh H SO2Ph HSO2Ph H SO2Ph HCONHMe H SO2Ph HCONHEt H SO2Ph HCONHPr-n H SO2Ph HCONHPr-i H SO2Ph HCONHBu-n H SO2Ph HCONHBu-sec H SO2Ph HCONHBu-t H SO2Ph HCON(Me)2 H SO2Ph HCON(Et)2 H SO2Ph HCON(Pr-n)2 H SO2Ph HF H CON(Et)2 HCl H CON(Et)2 HBr H CON(Et)2 HI H CON(Et)2 HCH＝CH2 H CON(Et)2 HCH2CH＝CH2 H CON(Et)2 HC≡CH H CON(Et)2 HCH2C≡CH H CON(Et)2 HCH2F H CON(Et)2 HCHF2 H CON(Et)2 HCN H CON(Et)2 HNH2 H CON(Et)2 HR3 R2 R1 R4NHCOMe H CON(Et)2 HCH2NH2 H CON(Et)2 HCH2NHCOMe H CON(Et)2 HCH2OCHF2 H CON(Et)2 HCH2OCF3 H CON(Et)2 HCF3 H CON(Et)2 HNO2 H CON(Et)2 HOMe H CON(Et)2 HOEt H CON(Et)2 HOPr-n H CON(Et)2 HOBu-n H CON(Et)2 HOPen-n H CON(Et)2 HSMe H CON(Et)2 HSEt H CON(Et)2 HSPr-n H CON(Et)2 HSBu-n H CON(Et)2 HSPen-n H CON(Et)2 HSO2Me H CON(Et)2 HSO2Et H CON(Et)2 HSO2Pr-n H CON(Et)2 HCOMe H CON(Et)2 HCOEt H CON(Et)2 HCOPr-n H CON(Et)2 HCO2H H CON(Et)2 HCO2Me H CON(Et)2 HCO2Et H CON(Et)2 HCO2Pr-n H CON(Et)2 HCO2Bu-n H CON(Et)2 HCO2Pen-n H CON(Et)2 HCH2Cl H CON(Et)2 HCH2Br H CON(Et)2 HCH2I H CON(Et)2 HCH2CF3 H CON(Et)2 HCH2CN H CON(Et)2 HCH2OH H CON(Et)2 HCH2OMe H CON(Et)2 HCH2OEt H CON(Et)2 HCH2OPr-n H CON(Et)2 HCH2SMe H CON(Et)2 HCH2SEt H CON(Et)2 HR3 R2 R1 R4CH2SPr-n H CON(Et)2 HCH2SO2Me H CON(Et)2 HCH2SO2Et H CON(Et)2 HCH2SO2Pr-n H CON(Et)2 HCH2COMe H CON(Et)2 HCH2COEt H CON(Et)2 HCH2COPr-n H CON(Et)2 HCH2CO2H H CON(Et)2 HCH2CO2H H CON(Et)2 HCH2CO2Me H CON(Et)2 HCH2CO2Et H CON(Et)2 HCH2CO2Pr-n H CON(Et)2 HCH2OCH2CH＝CH2 H CON(Et)2 HCH2OCH2C≡CH H CON(Et)2 HCH＝CHCO2Me H CON(Et)2 HCH＝CHCO2Et H CON(Et)2 HCH＝CHCO2Pr-n H CON(Et)2 HCH＝CHCN H CON(Et)2 HPh H CON(Et)2 HCH2Ph H CON(Et)2 HOPh H CON(Et)2 HSPh H CON(Et)2 HSO2Ph H CON(Et)2 HCONHMe H CON(Et)2 HCONHEt H CON(Et)2 HCONHPr-n H CON(Et)2 HCONHPr-i H CON(Et)2 HCONHBu-n H CON(Et)2 HCONHBu-sec H CON(Et)2 HCONHBu-t H CON(Et)2 HCON(Me)2 H CON(Et)2 HCON(Et)2 H CON(Et)2 HCON(Pr-n)2 H CON(Et)2 HF H CN HCl H CN HBr H CN HI H CN HCH＝CH2 H CN HCH2CH＝CH2 H CN HC≡CH H CN HCH2C≡CH H CN HR3 R2 R1 R4CH2F H CN HCHF2 H CN HCN H CN HNH2 H CN HNHCOMe H CN HCH2NH2 H CN HCH2NHCOMe H CN HCH2OCHF2 H CN HCH2OCF3 H CN HCF3 H CN HNO2 H CN HOMe H CN HOEt H CN HOPr-n H CN HOBu-n H CN HOPen-n H CN HSMe H CN HSEt H CN HSPr-n H CN HSBu-n H CN HSPen-n H CN HSO2Me H CN HSO2Et H CN HSO2Pr-n H CN HCOMe H CN HCOEt H CN HCOPr-n H CN HCO2H H CN HCO2Me H CN HCO2Et H CN HCO2Pr-n H CN HCO2Bu-n H CN HCO2Pen-n H CN HCH2Cl H CN HCH2Br H CN HCH2I H CN HCH2CF3 H CN HCH2CN H CN HCH2OH H CN HCH2OMe H CN HCH2OEt H CN HCH2OPr-n H CN HR3 R2 R1 R4CH2SMe H CN HCH2SEt H CN HCH2SPr-n H CN HCH2SO2Me H CN HCH2SO2Et H CN HCH2SO2Pr-n H CN HCH2COMe H CN HCH2COEt H CN HCH2COPr-n H CN HCH2CO2H H CN HCH2CO2Me H CN HCH2CO2Et H CN HCH2CO2Pr-n H CN HCH2OCH2CH＝CH2 H CN HCH2OCH2C≡CH H CN HCH＝CHCO2Me H CN HCH＝CHCO2Et H CN HCH＝CHCO2Pr-n H CN HCH＝CHCN H CN HPh H CN HCH2Ph H CN HOPh H CN HSPh H CN HH Br Me HMe Br H HSO2Ph H CN HCONHMe H CN HCONHEt H CN HCONHPr-n H CN HCONHPr-i H CN HCONHBu-n H CN HCONHBu-sec H CN HCONHBu-t H CN HCON(Me)2 H CN HCON(Et)2 H CN HCON(Pr-n)2 H CN HCl Cl H HH Cl Cl HBr Br H HBr H Br HH Br Br HH Cl Me HMe Cl H H
R1 R2 R3 R4 R5H H H H HMe H H H HH Me H M HH H Me H HH H H Me HEt H H H HH Et H H HH H Et H HH H H Et HPr-n H H H HH Pr-n H H HH H Pr-n H HH H H Pr-n HPr-i H H H HH Pr-i H H HH H Pr-i H HH H H Pr-i HBu-n H H H HH Bu-n H H HH H Bu-n H HH H H Bu-n HH H H Me MeMe H H Me MeH Me H Me MeH H Me Me MeEt H H Me MeH Et H Me MeH H Et Me MePr-n H H Me MeH Pr-n H Me MeH H Pr-n Me MeR1 R2 R3 R4 R5Pr-i H H Me MeH Pr-i H Me MeH H Pr-i Me MeBu-n H H Me MeH Bu-n H Me MeH H Bu-n Me MeMe Me H Me MeMe H Me Me MeH Me Me Me MeMe Me Me Me MeEt Et H Me MeEt H Et Me MeH Et Et Me MeEt Et Et Me MeMe H Et Me MeEt Me H Me MeEt H Me Me MeMe Et H Me MeH Me Et Me MeH Et Me Me MeH H H Me EtMe H H Me EtH Me H Me EtH H Me Me EtEt H H Me EtH Et H Me EtH H Et Me EtPr-n H H Me EtH Pr-n H Me EtH H Pr-n Me EtPr-i H H Me EtH Pr-i H Me EtH H Pr-i Me EtBu-n H H Me EtH Bu-n H Me EtH H Bu-n Me EtMe Me H Me EtMe H Me Me EtH Me Me Me EtMe Me Me Me EtR1 R2 R3 R4 R5Et Et H Me EtEt H Et Me EtH Et Et Me EtEt Et Et Me EtMe H Et Me EtEt Me H Me EtEt H Me Me EtMe Et H Me EtH Me Et Me EtH Et Me Me EtH H H Me Pr-nMe H H Me Pr-nH Me H Me Pr-nH H Me Me Pr-nEt H H Me Pr-nH Et H Me Pr-nH H Et Me Pr-nPr-n H H Me Pr-nH Pr-n H Me Pr-nH H Pr-n Me Pr-nPr-i H H Me Pr-nH Pr-i H Me Pr-nH H Pr-i Me Pr-nBu-n H H Me Pr-nH Bu-n H Me Pr-nH H Bu-n Me Pr-nMe Me H Me Pr-nMe H Me Me Pr-nH Me Me Me Pr-nMe Me Me Me Pr-nEt Et H Me Pr-nEt H Et Me Pr-nH Et Et Me Pr-nEt Et Et Me Pr-nMe H Et Me Pr-nEt Me H Me Pr-nEt H Me Me Pr-nMe Et H Me Pr-nH Me Et Me Pr-nH Et Me Me Pr-nR1 R2 R3 R4 R5H H H Me Pr-iMe H H Me Pr-iH Me H Me Pr-iH H Me Me Pr-iEt H H Me Pr-iH Et H Me Pr-iH H Et Me Pr-iPr-n H H Me Pr-iH Pr-n H Me Pr-iH H Pr-n Me Pr-iPr-i H H Me Pr-iH Pr-i H Me Pr-iH H Pr-i Me Pr-iBu-n H H Me Pr-iH Bu-n H Me Pr-iH H Bu-n Me Pr-iMe Me H Me Pr-iMe H Me Me Pr-iH Me Me Me Pr-iMe Me Me Me Pr-iEt Et H Me Pr-iEt H Et Me Pr-iH Et Et Me Pr-iEt Et Et Me Pr-iMe H Et Me Pr-iEt Me H Me Pr-iEt H Me Me Pr-iMe Et H Me Pr-iH Me Et Me Pr-iH Et Me Me Pr-iH H H Et EtMe H H Et EtH Me H Et EtH H Me Et EtEt H H Et EtH Et H Et EtH H Et Et EtPr-n H H Et EtH Pr-n H Et EtH H Pr-n Et EtR1 R2 R3 R4 R5Pr-i H H Et EtH Pr-i H Et EtH H Pr-i Et EtBu-n H H Et EtH Bu-n H Et EtH H Bu-n Et EtMe Me H Et EtMe H Me Et EtH Me Me Et EtMe Me Me Et EtEt Et H Et EtEt H Et Et EtH Et Et Et EtEt Et Et Et EtMe H Et Et EtEt Me H Et EtEt H Me Et EtMe Et H Et EtH Me Et Et EtH Et Me Et EtH H H Et EtF H H Me MeCl H H Me MeBr H H Me MeI H H Me MeCH＝CH2 H H Me MeCH2CH＝CH2H H Me MeC≡CH H H Me MeCH2C≡CH H H Me MeCH2F H H Me MeCHF2 H H Me MeCN H H Me MeNH2 H H Me MeNHCOMe H H Me MeCH2NH2 H H Me MeCH2NHCOMe H H Me MeCH2OCHF2 H H Me MeCH2OCF3 H H Me MeCF3 H H Me MeNO2 H H Me MeR1 R2 R3 R4 R5OMe H H Me MeOEt H H Me MeOPr-n H H Me MeSMe H H Me MeSEt H H Me MeSPr-n H H Me MeSBu-n H H Me MeSPen-n H H Me MeSO2Me H H Me MeSO2Et H H Me MeSO2Pr-n H H Me MeCOMe H H Me MeCOEt H H Me MeCOPr-n H H Me MeCO2H H H Me MeCO2Me H H Me MeCO2Et H H Me MeCO2Pr-n H H Me MeCO2Pr-i H H Me MeCO2Bu-n H H Me MeCO2Bu-t H H Me MeCO2Bu-sec H H Me MeCO2Pen-n H H Me MeCH2Cl H H Me MeCH2Br H H Me MeCH2I H H Me MeCH2CF3 H H Me MeCH2CN H H Me MeCH2OH H H Me MeCH2OMe H H Me MeCH2OEt H H Me MeCH2OPr-n H H Me MeCH2OPr-i H H Me MeCH2SMe H H Me MeCH2SEt H H Me MeCH2SPr-n H H Me MeCH2SPr-i H H Me MeCH2SO2Me H H Me MeCH2SO2Et H H Me MeCH2SO2Pr-n H H Me MeR1 R2 R3 R4 R5CH2SO2Pr-i H H Me MeCH2COMe H H Me MeCH2COEt H H Me MeCH2COPr-n H H Me MeCH2COPr-i H H Me MeCH2CO2H H H Me MeCH2CO2Me H H Me MeCH2CO2Pr-n H H Me MeCH2CO2Pr-i H H Me MeCH2OCH2CH＝CH2 H H Me MeCH2OCH2C≡CH H H Me MeCH＝CHCO2Me H H Me MeCH＝CHCO2Et H H Me MeCH＝CHCO2Pr-n H H Me MeCH＝CHCO2Pr-i H H Me MeCH＝CHCN H H Me MePh H H Me MeCH2Ph H H Me MeOPh H H Me MeSPh H H Me MeSO2Ph H H Me MeCONHMe H H Me MeCONHEt H H Me MeCONHPr-n H H Me MeCONHPr-i H H Me MeCONHBu-n H H Me MeCONHBu-sec H H Me MeCONHBu-t H H Me MeCON(Me)2 H H Me MeCON(Et)2 H H Me MeCON(Pr-n)2 H H Me MeF H H Me EtCl H H Me EtBr H H Me EtI H H Me EtCH＝CH2 H H Me EtCH2CH＝CH2 H H Me EtC≡CH H H Me EtCH2C≡CH H H Me EtR1 R2 R3 R4 R5CH2F H H Me EtCHF2 H H Me EtCN H H Me EtNH2 H H Me EtNHCOMe H H Me EtCH2NH2 H H Me EtCH2NHCOMe H H Me EtCH2OCHF2 H H Me EtCH2OCF3 H H Me EtCF3 H H Me EtNO2 H H Me EtOMe H H Me EtOEt H H Me EtOPr-n H H Me EtSMe H H Me EtSEt H H Me EtSPr-n H H Me EtSBu-n H H Me EtSPen-n H H Me EtSO2Me H H Me EtSO2Et H H Me EtSO2Pr-n H H Me EtCOMe H H Me EtCOEt H H Me EtCOPr-n H H Me EtCO2H H H Me EtCO2Me H H Me EtCO2Et H H Me EtCO2Pr-n H H Me EtCO2Pr-i H H Me EtCO2Bu-n H H Me EtCO2Bu-t H H Me EtCO2Bu-sec H H Me EtCO2Pen-n H H Me EtCH2Cl H H Me EtCH2Br H H Me EtCH2I H H Me EtCH2CF3 H H Me EtCH2CN H H Me EtCH2OH H H Me EtR1 R2 R3 R4 R5CH2OMe H H Me EtCH2OEt H H Me EtCH2OPr-n H H Me EtCH2OPr-i H H Me EtCH2SMe H H Me EtCH2SEt H H Me EtCH2SPr-n H H Me EtCH2SPr-i H H Me EtCH2SO2Me H H Me EtCH2SO2Et H H Me EtCH2SO2Pr-n H H Me EtCH2SO2Pr-i H H Me EtCH2COMe H H Me EtCH2COEt H H Me EtCH2COPr-n H H Me EtCH2COPr-i H H Me EtCH2CO2H H H Me EtCH2CO2Me H H Me EtCH2CO2Et H H Me EtCH2CO2Pr-n H H Me EtCH2CO2Pr-i H H Me EtCH2OCH2CH＝CH2 H H Me EtCH2OCH2C≡CH H H Me EtCH＝CHCO2Me H H Me EtCH＝CHCO2Et H H Me EtCH＝CHCO2Pr-n H H Me EtCH＝CHCO2Pr-i H H Me EtCH＝CHCN H H Me EtPh H H Me EtCH2Ph H H Me EtOPh H H Me EtSPh H H Me EtSO2Ph H H Me EtCONHMe H H Me EtCONHEt H H Me EtCONHPr-n H H Me EtCONHPr-i H H Me EtCONHBu-n H H Me EtCONHBu-sec H H Me EtCONHBu-t H H Me EtR1 R2 R3 R4 R5CON(Me)2 H H Me EtCON(Et)2 H H Me EtCON(Pr-n)2 H H Me EtH F H Me MeH Cl H Me MeH Br H Me MeH I H Me MeH CH＝CH2 H Me MeH CH2CH＝CH H Me MeH C≡CH H Me MeH CH2C≡CH H Me MeH CH2F H Me MeH CHF2 H Me MeH CN H Me MeH NH2 H Me MeH NHCOMe H Me MeH CH2NH2 H Me MeH CH2NHCOMe H Me MeH CH2OCHF2 H Me MeH CH2OCF3 H Me MeH CF3 H Me MeH NO2 H Me MeH OMe H Me MeH OEt H Me MeH OPr-n H Me MeH SMe H Me MeH SEt H Me MeH SPr-n H Me MeH SBu-n H Me MeH SPen-n H Me MeH SO2Me H Me MeH SO2Et H Me MeH SO2Pr-n H Me MeH COMe H Me MeH COEt H Me MeH COPr-n H Me MeH CO2H H Me MeH CO2Me H Me MeH CO2Et H Me MeH CO2Pr-n H Me MeR1 R2 R3 R4 R5H CO2Pr-i H Me MeH CO2Bu-n H Me MeH CO2Bu-t H Me MeH CO2Bu-sec H Me MeH CO2Pen-n H Me MeH CH2Cl H Me MeH CH2Br H Me MeH CH2I H Me MeH CH2CF3 H Me MeH CH2CN H Me MeH CH2OH H Me MeH CH2OMe H Me MeH CH2OEt H Me MeH CH2OPr-n H Me MeH CH2OPr-i H Me MeH CH2SMe H Me MeH CH2SEt H Me MeH CH2SPr-n H Me MeH CH2SPr-n H Me MeH CH2SO2Me H Me MeH CH2SO2Et H Me MeH CH2SO2Pr-n H Me MeH CH2SO2Pr-i H Me MeH CH2COMe H Me MeH CH2COEt H Me MeH CH2COPr-n H Me MeH CH2COPr-i H Me MeH CH2CO2H H Me MeH CH2CO2Me H Me MeH CH2CO2Et H Me MeH CH2CO2Pr-n H Me MeH CH2CO2Pr-i H Me MeH CH2OCH2CH＝CH2 H Me MeH CH2OCH2C≡CH H Me MeH CH＝CHCO2Ee H Me MeH CH＝CHCO2Et H Me MeH CH＝CHCO2Pr-n H Me MeH CH＝CHCO2Pr-i H Me MeH CH＝CHCN H Me MeH Ph H Me MeR1 R2 R3 R4 R5H CH2Ph H Me MeH OPh H Me MeH SPh H Me MeH SO2Ph H Me MeH CONHMe H Me MeH CONHEt H Me MeH CONHPr-n H Me MeH CONHPr-i H Me MeH GONHBu-n H Me MeH CONHBu-sec H Me MeH CONHBu-t H Me MeH CON(Me)2 H Me MeH CON(Et)2 H Me MeH CON(Pr-n)2 H Me MeH H F Me MeH H Cl Me MeH H Br Me MeH H I Me MeH H CH＝CH2 Me MeH H CH2CH＝CH2 Me MeH H C≡CH Me MeH H CH2C≡CH Me MeH H CH2F Me MeH H CHF2 Me MeH H CN Me MeH H NH2 Me MeH H NHCOMe Me MeH H CH2NH2 Me MeH H CH2NHCOMe Me MeH H CH2OCHF2 Me MeH H CH2OCF3 Me MeH H CF3 Me MeH H NO2 Me MeH H OMe Me MeH H OEt Me MeH H OPr-n Me MeH H SMe Me MeH H SEt Me MeH H SPr-n Me MeH H SBu-n Me MeR1 R2 R3 R4 R5H H SPen-n Me MeH H SO2Me Me MeH H SO2Et Me MeH H SO2Pr-n Me MeH H COMe Me MeH H COEt Me MeH H COPr-n Me MeH H CO2H Me MeH H CO2Me Me MeH H CO2Et Me MeH H CO2Pr-n Me MeH H CO2Pr-i Me MeH H CO2Bu-n Me MeH H CO2Bu-t Me MeH H CO2Bu-sec Me MeH H CO2Pen-n Me MeH H CH2Cl Me MeH H CH2Br Me MeH H CH2I Me MeH H CH2CF3 Me MeH H CH2CN Me MeH H CH2OH Me MeH H CH2OMe Me MeH H CH2OEt Me MeH H CH2OPr-n Me MeH H CH2OPr-i Me MeH H CH2SMe Me MeH H CH2SEt Me MeH H CH2SPr-n Me MeH H CH2SPr-i Me MeH H CH2SO2Me Me MeH H CH2SO2Et Me MeH H CH2SO2Pr-n Me MeH H CH2SO2Pr-i Me MeH H CH2COMe Me MeH H CH2COEt Me MeH H CH2COPr-n Me MeH H CH2COPr-i Me MeH H CH2CO2H Me MeH H CH2CO2Me Me MeR1 R2 R3 R4 R5H H CH2CO2Et Me MeH H CH2CO2Pr-n Me MeH H CH2CO2Pr-i Me MeH H CH2OCH2CH＝CH2 Me MeH H CH2OCH2C≡CH Me MeH H CH＝CHCO2Me Me MeH H CH＝CHCO2Et Me MeH H CH＝CHCO2Pr-n Me MeH H CH＝CHCO2Pr-i Me MeH H CH＝CHCN Me MeH H Ph Me MeH H CH2Ph Me MeH H OPh Me MeH H SPh Me MeH H SO2Ph Me MeH H CONHMe Me MeH H CONHEt Me MeH H CONHPr-n Me MeH H CONHPr-i Me MeH H CONHBu-n Me MeH H CONHBu-sec Me MeH H CONHBu-t Me MeH H CON(Me)2 Me MeH H CON(Et)2 Me MeH H CON(Pr-n)2 Me MeH H H F HH H H Cl HH H H Br HH H H I HH H H CH＝CH2 HH H H CH2CH＝CH2 HH H H C≡CH HH H H CH2C≡CH HH H H CH2F HH H H CHF2 HH H H CN HH H H NH2 HH H H NHCOMe HH H H CH2NH2 HH H H CH2NHCOMe HR1 R2 R3 R4 R5H H H CH2OCHF2 HH H H CH2OCF3 HH H H CF3 HH H H NO2 HH H H OMe HH H H OEt HH H H OPr-n HH H H SMe HH H H SEt HH H H SPr-n HH H H SBu-n HH H H SPen-n HH H H SO2Me HH H H SO2Et HH H H SO2Pr-n HH H H COMe HH H H COEt HH H H COPr-n HH H H CO2H HH H H CO2Me HH H H CO2Et HH H H CO2Pr-n HH H H CO2Pr-i HH H H CO2Bu-n HH H H CO2Bu-t HH H H CO2Bu-sec HH H H CO2Pen-n HH H H CH2Cl HH H H CH2Br HH H H CH2I HH H H CH2CF3 HH H H CH2CN HH H H CH2OH HH H H CH2OMe HH H H CH2OEt HH H H CH2OPr-n HR1 R2 R3 R4 R5H H H CH2OPr-i HH H H CH2SMe HH H H CH2SEt HH H H CH2SPr-n HH H H CH2SPr-i HH H H CH2SO2Me HH H H CH2SO2Et HH H H CH2SO2Pr-n HH H H CH2SO2Pr-i HH H H CH2COMe HH H H CH2COEt HH H H CH2COPr-n HH H H CH2COPr-i HH H H CH2CO2H HH H H CH2CO2Me HH H H CH2CO2Et HH H H CH2CO2Pr-n HH H H CH2CO2Pr-i HH H H CH2OCH2CH＝CH2 HH H H CH2OCH2C≡CH HH H H CH＝CHCO2Me HH H H CH＝CHCO2Et HH H H CH＝CHCO2Pr-n HH H H CH＝CHCO2Pr-i HH H H CH＝CHCN HH H H Ph HH H H Ph-2-F HH H H Ph-3-F HH H H Ph-4-F HH H H Ph-2-Cl HH H H Ph-3-Cl HH H H Ph-4-Cl HH H H Ph-2-Br HH H H Ph-3-Br HH H H Ph-4-Br HH H H Ph-2-CF3 HH H H Ph-3-CF3 HH H H Ph-4-CF3 HH H H Ph-2-Me HH H H Ph-3-Me HR1 R2 R3 R4 R5H H H Ph-4-Me HH H H Ph-2-Et HH H H Ph-2-OMe HH H H Ph-3-OMe HH H H Ph-4-OMe HH H H Ph-2-OEt HH H H Ph-2-CO2Me HH H H Ph-2-CO2Et HH H H Ph-3-CO2Me HH H H Ph-4-CO2Me HH H H CH2Ph HH H H CH2Ph-2-F HH H H CH2Ph-3-F HH H H CH2Ph-4-F HH H H CH2Ph-2-Cl HH H H CH2Ph-3-Cl HH H H CH2Ph-4-Cl HH H H CH2Ph-2-Br HH H H CH2Ph-3-Br HH H H CH2Ph-4-Br HH H H CH2Ph-2-CF3 HH H H CH2Ph-3-CF3 HH H H CH2Ph-4-CF3 HH H H CH2Ph-2-Me HH H H CH2Ph-3-Me HH H H CH2Ph-4-Me HH H H CH2Ph-2-Et HH H H CH2Ph-2-OMe HH H H CH2Ph-3-OMe HH H H CH2Ph-4-OMe HH H H CH2Ph-2-OEt HH H H CH2Ph-2-CO2Me HH H H CH2Ph-2-CO2Et HH H H CH2Ph-3-CO2Me HH H H CH2Ph-4-CO2Me HH H H OPh HH H H OPh-2-Cl HH H H OPh-3-Cl HH H H OPh-4-Cl HH H H OPh-2-F HR1 R2 R3 R4 R5H H H OPh-3-F HH H H OPh-4-F HH H H OPh-2-CF3 HH H H OPh-3-CF3 HH H H OPh-4-CF3 HH H H OPh-2-Me HH H H OPh-3-Me HH H H OPh-4-Me HH H H OPh-2-Et HH H H OPh-2-OMe HH H H OPh-3-OMe HH H H OPh-4-OMe HH H H OPh-2-OEt HH H H OPh-2-CO2Me HH H H OPh-3-CO2Me HH H H OPh-4-CO2Me HH H H OPh-2-CO2Et HH H H SPh HH H H SPh-2-Cl HH H H SPh-3-Cl HH H H SPh-4-Cl HH H H SPh-2-F HH H H SPh-3-F HH H H SPh-4-F HH H H SPh-2-CF3 HH H H SPh-3-CF3 HH H H SPh-4-CF3 HH H H SPh-2-Me HH H H SPh-3-Me HH H H SPh-4-Me HH H H SPh-2-Et HH H H SPh-2-OMe HH H H SPh-3-OMe HH H H SPh-4-OMe HH H H SPh-2-OEt HH H H SPh-2-CO2Me HH H H SPh-3-CO2Me HH H H SPh-4-CO2Me HH H H SPh-4-CO2Et HH H H SO2Ph HR1 R2 R3 R4 R5H H H SO2Ph-2-Cl HH H H SO2Ph-3-Cl HH H H SO2Ph-4-Cl HH H H SO2Ph-2-F HH H H SO2Ph-3-F HH H H SO2Ph-4-F HH H H SO2Ph-2-CF3 HH H H SO2Ph-3-CF3 HH H H SO2Ph-4-CF3 HH H H SO2Ph-2-Me HH H H SO2Ph-3-Me HH H H SO2Ph-4-Me HH H H SO2Ph-2-Et HH H H SO2Ph-2-OMe HH H H SO2Ph-3-OMe HH H H SO2Ph-4-OMe HH H H SO2Ph-2-OEt HH H H SO2Ph-2-CO2Me HH H H SO2Ph-3-CO2Me HH H H SO2Ph-4-CO2Me HH H H SO2Ph-2-CO2Et HH H H CONHMe HH H H CONHEt HH H H CONHPr-n HH H H CONHPr-i HH H H CONHBu-n HH H H CONHBu-sec HH H H CONHBu-t HH H H CON(Me)2 HH H H CON(Et)2 HH H H CON(Pr-n)2 HF H H H HCl H H H HBr H H H HI H H H HCH＝CH2 H H H HCH2CH＝CH2 H H H HC≡CH H H H HCH2C≡CH H H H HCH2F H H H HR1 R2 R3 R4 R5CHF2 H H H HCN H H H HNH2 H H H HNHCOMe H H H HCH2NH2 H H H HCH2NHCOMe H H H HCH2OCHF2 H H H HCH2OCF3 H H H HCF3 H H H HNO2 H H H HOMe H H H HOEt H H H HOPr-n H H H HSMe H H H HSEt H H H HSPr-n H H H HSBu-n H H H HSPen-n H H H HSO2Me H H H HSO2Et H H H HSO2Pr-n H H H HCOMe H H H HCOEt H H H HCOPr-n H H H HCO2H H H H HCO2Me H H H HCO2Et H H H HCO2Pr-n H H H HCO2Pr-i H H H HCO2Bu-n H H H HCO2Bu-t H H H HCO2Bu-sec H H H HCO2Pen-n H H H HCH2Cl H H H HCH2Br H H H HCH2I H H H HCH2CF3 H H H HCH2CN H H H HCH2OH H H H HCH2OMe H H H HR1 R2 R3 R4 R5CH2OEt H H H HCH2OPr-n H H H HCH2OPr-i H H H HCH2SMe H H H HCH2SEt H H H HCH2SPr-n H H H HCH2SPr-i H H H HCH2SO2Me H H H HCH2SO2Et H H H HCH2SO2Pr-n H H H HCH2SO2Pr-i H H H HCH2COMe H H H HCH2COEt H H H HCH2COPr-n H H H HCH2COPr-i H H H HCH2CO2H H H H HCH2CO2Me H H H HCH2CO2Et H H H HCH2CO2Pr-n H H H HCh2CO2Pr-i H H H HCH2OCH2CH＝CH2 H H H HCH2OCH2C≡CH H H H HCH＝CHCO2Me H H H HCH＝CHCO2Et H H H HCH＝CHCO2Pr-n H H H HCH＝CHCO2Pr-i H H H HCH＝CHCN H H H HPh H H H HPh-2-F H H H HPh-3-F H H H HPh-4-F H H H HPh-2-Cl H H H HPh-3-Cl H H H HPh-4-Cl H H H HPh-2-Br H H H HPh-3-Br H H H HPh-4-Br H H H HPh-2-CF3 H H H HPh-3-CF3 H H H HPh-4-CF3 H H H HR1 R2 R3 R4 R5Ph-2-Me H H H HPh-3-Me H H H HPh-4-Me H H H HPh-2-Et H H H HPh-2-OMe H H H HPh-3-OMe H H H HPh-4-OMe H H H HPh-2-OEt H H H HPh-2-CO2Me H H H HPh-2-CO2Et H H H HPh-3-CO2Me H H H HPh-4-CO2Me H H H HCH2Ph H H H HCH2Ph-2-F H H H HCH2Ph-3-F H H H HCH2Ph-4-F H H H HCH2Ph-2-C H H H HCH2Ph-3-C H H H HCH2Ph-4-Cl H H H HCH2Ph-2-Br H H H HCH2Ph-3-Br H H H HCH2Pr-4-Br H H H HCH2Ph-2-CF3 H H H HCH2Ph-3-CF3 H H H HCH2Ph-4-CF3 H H H HCH2Ph-2-Me H H H HCH2Ph-3-Me H H H HCH2Ph-4-Me H H H HCH2Ph-2-Et H H H HCH2Ph-2-OMe H H H HCH2Ph-3-OMe H H H HCH2Ph-4-OMe H H H HCH2Ph-2-OEt H H H HCH2Ph-2-CO2Me H H H HCH2Ph-2-CO2Et H H H HCH2Ph-3-CO2Me H H H HCH2Ph-4-CO2Me H H H HOPh H H H HOPh-2-Cl H H H HOPh-3-Cl H H H HR1 R2 R3 R4 R5OPh-4-Cl H H H HOPh-2-F H H H HOPh-3-F H H H HOPh-4-F H H H HOPh-2-CF3 H H H HOPh-3-CF3 H H H HOPh-4-CF3 H H H HOPh-2-Me H H H HOPh-3-Me H H H HOPh-4-Me H H H HOPh-2-Et H H H HOPh-2-OMe H H H HOPh-3-OMe H H H HOPh-4-OMe H H H HOPh-2-OEt H H H HOPh-2-CO2Me H H H HOPh-3-CO2Me H H H HOPh-4-CO2Me H H H HOPh-2-CO2Et H H H HSPh H H H HSPh-2-Cl H H H HSPh-3-Cl H H H HSPh-4-Cl H H H HSPh-2-F H H H HSPh-3-F H H H HSPh-4-F H H H HSPh-2-CF3 H H H HSPh-3-CF3 H H H HSPh-4-CF3 H H H HSPh-2-Me H H H HSPh-3-Me H H H HSPh-4-Me H H H HSPh-2-Et H H H HSPh-2-OMe H H H HSPh-3-OMe H H H HSPh-4-OMe H H H HSPh-2-OEt H H H HSPh-2-CO2Me H H H HSPh-3-CO2Me H H H HSPh-4-CO2Me H H H HR1 R2 R3 R4 R5SPh-4-CO2Et H H H HSO2Ph H H H HSO2Ph-2-Cl H H H HSO2Ph-3-Cl H H H HSO2Ph-4-Cl H H H HSO2Ph-2-F H H H HSO2Ph-3-F H H H HSO2Ph-4-F H H H HSO2Ph-2-CF3 H H H HSO2Ph-3-CF3 H H H HSO2Ph-4-CF3 H H H HSO2Ph-2-Me H H H HSO2Ph-3-Me H H H HSO2Ph-4-Me H H H HSO2Ph-2-Et H H H HSO2Ph-2-OMe H H H HSO2Ph-3-OMe H H H HSO2Ph-4-OMe H H H HSO2Ph-2-OEt H H H HSO2Ph-2-CO2Me H H H HSO2Ph-3-CO2Me H H H HSO2Ph-4-CO2Me H H H HSO2Ph-2-CO2Et H H H HCONHMe H H H HCONHEt H H H HCONHPr-n H H H HCONHPr-i H H H HCONHBu-n H H H HCONHBu-sec H H H HCONHBu-t H H H HCON(Me)2 H H H HCON(Et)2 H H H HCON(Pr-n)2 H H H HH F H H HH Cl H H HH Br H H HH I H H HH CH＝CH2 H H HH CH2CH＝CH2 H H HH C≡CH H H HR1 R2 R3 R4 R5H CH2C≡CH H H HH CH2F H H HH CHF2 H H HH CN H H HH NH2 H H HH NHCOMe H H HH CH2NH2 H H HH CH2NHCOMe H H HH CH2OCHF2 H H HH CH2OCFn H H HH CF3 H H HH NO2 H H HH OMe H H HH OEt H H HH OPr-n H H HH SMe H H HH SEt H H HH SPr-n H H HH SBu-n H H HH SPen-n H H HH SO2Me H H HH SO2Et H H HH SO2Pr-r H H HH COMe H H HH COEt H H HH COPr-n H H HH CO2H H H HH CO2Me H H HH CO2Et H H HH CO2Pr-n H H HH CO2Pr-i H H HH CO2Bu-n H H HH CO2Bu-t H H HH CO2Bu-sec H H HH CO2Pen-n H H HH CH2Cl H H HH CH2Br H H HH CH2I H H HH CH2CF3 H H HH CH2CN H H HR1 R2 R3 R4 R5H CH2OH H H HH CH2OMe H H HH CH2OEt H H HH CH2OPr-n H H HH CH2OPr-i H H HH CH2SMe H H HH CH2SEt H H HH CH2SPr-n H H HH CH2SPr-i H H HH CH2SO2Me H H HH CH2SO2Et H H HH CH2SO2Pr-n H H HH CH2SO2Pr-i H H HH CH2COMe H H HH CH2COEt H H HH CH2COPr-n H H HH CH2COPr-i H H HH CH2CO2H H H HH CH2CO2Me H H HH CH2CO2Et H H HH CH2CO2Pr-n H H HH CH2CO2Pr-i H H HH CH2OCH2CH＝CH H H HH CH2OCH2C≡Cl H H HH CH＝CHCO2Me H H HH CH＝CHCO2Et H H HH CH＝CHCO2Pr-n H H HH CH＝CHCO2Pr-i H H HH CH＝CHCN H H HH Ph H H HH Ph-2-F H H HH Ph-3-F H H HH Ph-4-F H H HH Ph-2-Cl H H HH Ph-3-Cl H H HH Ph-4-Cl H H HH Ph-2-Br H H HH Ph-3-Br H H HH Ph-4-Br H H HH Ph-2-CF3 H H HR1 R2 R3 R4 R5H Ph-3-CF3 H H HH Ph-4-CF3 H H HH Ph-2-Me H H HH Ph-3-Me H H HH Ph-4-Me H H HH Ph-2-Et H H HH Ph-2-OMe H H HH Ph-3-OMe H H HH Ph-4-OMe H H HH Ph-2-OEt H H HH Ph-2-CO2Me H H HH Ph-2-CO2Et H H HH Ph-3-CO2Me H H HH Ph-4-CO2Me H H HH CH2Ph H H HH CH2Ph-2-F H H HH CH2Ph-3-F H H HH CH2Ph-4-F H H HH CH2Ph-2-Cl H H HH CH2Ph-3-Cl H H HH CH2Ph-4-Cl H H HH CH2Ph-2-Br H H HH CH2Ph-3-Br H H HH CH2Ph-4-Br H H HH CH2Ph-2 CF H H HH CH2Ph-3 CF H H HH CH2Ph-4-CF H H HH CH2Ph-2 Me H H HH CH2Ph-3-Me H H HH CH2Ph-4-Me H H HH CH2Ph-2-Et H H HH CH2Ph-2-OMe H H HH CH2Ph-3-OMe H H HH CH2Ph-4-OMe H H HH CH2Ph-2-OEt H H HH CH2Ph-2-CO2Me H H HH CH2Ph-2-CO2Et H H HH CH2Ph-3-CO2Me H H HH CH2Ph-4-CO2Me H H HH OPh H H HR1 R2 R3 R4 R5H OPh-2-Cl H H HH OPh-3-Cl H H HH OPh-4-Cl H H HH OPh-2-F H H HH OPh-3-F H H HH OPh-4-F H H HH OPh-2-CF3 H H HH OPh-3-CF3 H H HH OPh-4-CF3 H H HH OPh-2-Me H H HH OPh-3-Me H H HH OPh-4-Me H H HH OPh-2-Et H H HH OPh-2-OMe H H HH OPh-3-OMe H H HH OPh-4-OMe H H HH OPh-2-OEt H H HH OPh-2-CO2Me H H HH OPh-3-CO2Me H H HH OPh-4-CO2Me H H HH OPh-2-CO2Et H H HH SPh H H HH SPh-2-Cl H H HH SPh-3-Cl H H HH SPh-4-Cl H H HH SPh-2-F H H HH SPh-3-F H H HH SPh-4-F H H HH SPh-2-CF3 H H HH SPh-3-CF3 H H HH SPh-4-CF3 H H HH SPh-2-Me H H HH SPh-3-Me H H HH SPh-4-Me H H HH SPh-2-Et H H HH SPh-2-OMe H H HH SPh-3-OMe H H HH SPh-4-OMe H H HH SPh-2-OEt H H HH SPh-2-CO2Me H H HR1 R2 R3 R4 R5H SPh-3-CO2Me H H HH SPh-4-CO2Me H H HH SPh-4-CO2Et H H HH SO2Ph H H HH SO2Ph-2-Cl H H HH SO2Ph-3-Cl H H HH SO2Ph-4-Cl H H HH SO2Ph-2-F H H HH SO2Ph-3-F H H HH SO2Ph-4-F H H HH SO2Ph-2-CF3 H H HH SO2Ph-3-CF3 H H HH SO2Ph-4-CF3 H H HH SO2Ph-2-Me H H HH SO2Ph-3-Me H H HH SO2Ph-4-Me H H HH SO2Ph-2-Et H H HH SO2Ph-2-OMe H H HH SO2Ph-3-OMe H H HH SO2Ph-4-OMe H H HH SO2Ph-2-OE t H H HH SO2Ph-2-CO2Me H H HH SO2Ph-3-CO2Me H H HH SO2Ph-4-CO2Me H H HH SO2Ph-2-CO2Et H H HH CONHMe H H HH CONHEt H H HH CONHPr-n H H HH CONHPr-i H H HH CONHBu-n H H HH CONHBu-sec H H HH CONHBu-t H H HH CON(Me)2 H H HH CON(Et)2 H H HH CON(Pr-n)2 H H HH H F H HH H Cl H HH H Br H HH H I H HH H CH＝CH2 H HR1 R2 R3 R4 R5H H CH2CH＝CH2 H HH H C≡CH H HH H CH2C≡CH H HH H CH2F H HH H CHF2 H HH H CN H HH H NH2 H HH H NHCOMe H HH H CH2NH2 H HH H CH2NHCOMe H HH H CH2OCHF2 H HH H CH2OCF3 H HH H CF3 H HH H NO2 H HH H OMe H HH H OEt H HH H OPr-n H HH H SMe H HH H SEt H HH H SPr-n H HH H SBu-n H HH H SPen-n H HH H SO2Me H HH H SO2Et H HH H SO2Pr-n H HH H COMe H HH H COEt H HH H COPr-n H HH H CO2H H HH H CO2Me H HH H CO2Et H HH H CO2Pr-n H HH H CO2Pr-i H HH H CO2Bu-n H HH H CO2Bu-t H HH H CO2Bu-sec H HH H CO2Pen-n H HH H CH2Cl H HH H CH2Br H HH H CH2I H HR1 R2 R3 R4 R5H H CH2CF3 H HH H CH2CN H HH H CH2OH H HH H CH2OMe H HH H CH2OEt H HH H CH2OPr-n H HH H CH2OPr-i H HH H CH2SMe H HH H CH2SEt H HH H CH2SPr-n H HH H CH2SPr-i H HH H CH2SO2Me H HH H CH2SO2Et H HH H CH2SO2Pr-n H HH H CH2SO2Pr-i H HH H CH2COMe H HH H CH2COEt H HH H CH2COPr-n H HH H CH2COPr-i H HH H CH2CO2H H HH H CH2CO2Me H HH H CH2CO2Et H HH H CH2CO2Pr-n H HH H CH2CO2Pr-i H HH H CH2OCH2CH＝CH2 H HH H CH2OCH2C≡CH H HH H CH＝CHCO2Me H HH H CH＝CHCO2Et H HH H CH＝CHCO2Pr-n H HH H CH＝CHCO2Pr-i H HH H CH＝CHCN H HH H Ph H HH H Ph-2-F H HH H Ph-3-F H HH H Ph-4-F H HH H Ph-2-Cl H HH H Ph-3-Cl H HH H Ph-4-Cl H HH H Ph-2-Br H HH H Ph-3-Br H HR1 R2 R3 R4 R5H H Ph-4-Br H HH H Ph-2-CF3 H HH H Ph-3-CF3 H HH H Ph-4-CF3 H HH H Ph-2-Me H HH H Ph-3-Me H HH H Ph-4-Me H HH H Ph-2-Et H HH H Ph-2-OMe H HH H Ph-3-OMe H HH H Ph-4-OMe H HH H Ph-2-OEt H HH H Ph-2-CO2Me H HH H Ph-2-CO2Et H HH H Ph-3-CO2Me H HH H Ph-4-CO2Me H HH H CH2Ph H HH H CH2Ph-2-F H HH H CH2Ph-3-F H HH H CH2Ph-4-F H HH H CH2Ph-2-Cl H HH H CH2Ph-3-Cl H HH H CH2Ph-4-Cl H HH H CH2Ph-2-Br H HH H CH2Ph-3-Br H HH H CH2Ph-4-Br H HH H CH2Ph-2-CF3 H HH H CH2Ph-3-CF3 H HH H CH2Ph-4-CF3 H HH H CH2Ph-2-Me H HH H CH2Ph-3-Me H HH H CH2Ph-4-Me H HH H CH2Ph-2-Et H HH H CH2Ph-2-OMe H HH H CH2Ph-3-OMe H HH H CH2Ph-4-OMe H HH H CH2Ph-2-OEt H HH H CH2Ph-2-CO2Me H HH H CH2Ph-2-CO2Et H HH H CH2Ph-3-CO2Me H HR1 R2 R3 R4 R5H H CH2Ph-4-CO2Me H HH H OPh H HH H OPh-2-Cl H HH H OPh-3-Cl H HH H OPh-4-Cl H HH H OPh-2-F H HH H OPh-3-F H HH H OPh-4-F H HH H OPh-2-CF3 H HH H OPh-3-CF3 H HH H OPh-4-CE3 H HH H OPh-2-Me H HH H OPh-3-Me H HH H OPh-4-Me H HH H OPh-2-Et H HH H OPh-2-OMe H HH H OPh-3-OMe H HH H OPh-4-OMe H HH H OPh-2-OEt H HH H OPh-2-CO2Me H HH H OPh-3-CO2Me H HH H OPh-4-CO2Me H HH H OPh-2-CO2Et H HH H SPh H HH H SPh-2-Cl H HH H SPh-3-Cl H HH H SPh-4-Cl H HH H SPh-2-F H HH H SPh-3-F H HH H SPh-4-F H HH H SPh-2-CF3 H HH H SPh-3-CF3 H HH H SPh-4-CF3 H HH H SPh-2-Me H HH H SPh-3-Me H HH H SPh-4-Me H HH H SPh-2-Et H HH H SPh-2-OMe H HH H SPh-3-OMe H HH H SPh-4-OMe H HR1 R2 R3 R4 R5H H SPh-2-OEt H HH H SPh-2-CO2Me H HH H SPh-3-CO2Me H HH H SPh-4-CO2Me H HH H SPh-4-CO2Et H HH H SO2Ph H HH H SO2Ph-2-Cl H HH H SO2Ph-3-Cl H HH H SO2Ph-4-Cl H HH H SO2Ph-2-F H HH H SO2Ph-3-F H HH H SO2Ph-4-F H HH H SO2Ph-2-CF3 H HH H SO2Ph-3-CF3 H HH H SO2Ph-4-CF3 H HH H SO2Ph-2-Me H HH H SO2Ph-3-Me H HH H SO2Ph-4-Me H HH H SO2Ph-2-Et H HH H SO2Ph-2-OMe H HH H SO2Ph-3-OMe H HH H SO2Ph-4-OMe H HH H SO2Ph-2-OEt H HH H SO2Ph-2-CO2Me H HH H SO2Ph-3-CO2Me H HH H SO2Ph-4-CO2Me H HH H SO2Ph-2-CO2Et H HH H CONHMe H HH H CONHEt H HH H CONHPr-n H HH H CONHPr-i H HH H CONHBu-n H HH H CONHBu-sec H HH H CONHBu-t H HH H CON(Me)2 H HH H CON(Et)2 H HH H CON(Pr-n)2 H HR1 R2 R3 R4 R5Me Me H H HMe H Me H HMe H H Me HMe Et H H HMe H Et H HMe H H Et HMe Pr-n H H HMe H Pr-n H HMe H H Pr-n HMe Pr-i H H HMe H Pr-i H HMe H H Pr-i HMe Bu-n H H HMe H Bu-n H HMe H H Bu-n HEt Me H H HEt H Me H HEt H H Me HEt Et H H HEt H Et H HEt H H Et HEt Pr-n H H HEt H Pr-n H HEt H H Pr-n HEt Pr-i H H HEt H Pr-i H HEt H H Pr-i HEt Bu-n H H HEt H Bu-n H HEt H H Bu-n HPr-n Me H H HPr-n H Me H HPr-n H H Me HPr-n Et H H HPr-n H Et H HPr-n H H Et HPr-n Pr-n H H HPr-n H Pr-n H HPr-n H H Pr-n HPr-n Pr-i H H HR1 R2 R3 R4 R5Pr-n H Pr-i H HPr-n H H Pr-i HPr-n Bu-n H H HPr-n H Bu-n H HPr-n H H Bu-n HPr-i Me H H HPr-i H Me H HPr-i H H Me HPr-i Bt H H HPr-i H Et H HPr-i H H Et HPr-i Pr-n H H HPr-i H Pr-n H HPr-i H H Pr-n HPr-i Pr-i H H HPr-i H Pr-i H HPr-i H H Pr-i HPr-i Bu-n H H HPr-i H Bu-n H HPr-i H H Bu-n HBu-n Me H H HBu-n H Me H HBu-n H H Me HBu-n Et H H HBu-n H Et H HBu-n H H Et HBu-n Pr-n H H HBu-n H Pr-n H HBu-n H H Pr-n HBu-n Pr-i H H HBu-n H Pr-i H HBu-n H H Pr-i HBu-n Bu-n H H HBu-n H Bu-n H HBu-n H H Bu-n HH Me Me H HH Me H Me HH Me Et H HH Me H Et HH Me Pr-n H HR1 R2 R3 R4 R5H Me H Pr-n HH Me Pr-i H HH Me H Pr-i HH Et Me H HH Et H Me HH Et Et H HH Et H Et HH Et Pr-n H HH Et H Pr-n HH Et Pr-i H HH Et H Pr-i HH Pr-n Me H HH Pr-n H Me HH Pr-n Et H HH Pr-n H Et HH Pr-n Pr-n H HH Pr-n H Pr-n HH Pr-n Pr-i H HH Pr-n H Pr-i HH Pr-i Me H HH Pr-i H Me HH Pr-i Et H HH Pr-i H Et HH Pr-i Pr-n H HH Pr-i H Pr-n HH Pr-i Pr-i H HH Pr-i H Pr-i HH H Me Me HH H Me Et HH H Me Pr-n HH H Me Pr-i HH H Et Me HH h Et Et HH H Et Pr-n HH H Et Pr-i HH H Pr-n Me HH H Pr-n Et HH H Pr-n Pr-n HH H Pr-n Pr-i HH H Pr-i Me HR1 R2 R3 R4 R5H H Pr-i Et HH H Pr-i Pr-n HH H Pr-i Pr-i HMe Me Me H HMe Me Et H HMe Me Pr-n H HMe Me Pr-i H HMe Et Me H HMe Et Et H HMe Et Pr-n H HMe Et Pr-i H HMe Pr-n Me H HMe Pr-n Et H HMe Pr-n Pr-n H HMe Pr-n Pr-i H HMe Pr-i Me H HMe Pr-i Et H HMe Pr-i Pr-n H HMe Pr-i Pr-i H HEt Me Me H HEt Me Et H HEt Me Pr-n H HEt Me Pr-i H HEt Et Me H HEt Et Et H HEt Et Pr-n H HEt Et Pr-i H HEt Pr-n Me H HEt Pr-n Et H HEt Pr-n Pr-n H HEt Pr-n Pr-i H HEt Pr-i Me H HEt Pr-i Et H HEt Pr-i Pr-n H HEt Pr-i Pr-i H HPr-n Me Me H HPr-n Me Et H HPr-n Me Pr-n H HPr-n Me Pr-i H HPr-n Et Me H HR1 R2 R3 R4 R5Pr-n Et Et H HPr-n Et Pr-n H HPr-n Et Pr-i H HPr-n Pr-n Me H HPr-n Pr-n Et H HPr-n Pr-n Pr-n H HPr-n Pr-n Pr-i H HPr-n Pr-i Me H HPr-n Pr-i Et H HPr-n Pr-i Pr-n H HPr-n Pr-i Pr-i H HPr-i Me Me H HPr-i Me Et H HPr-i Me Pr-n H HPr-i Me Pr-i H HPr-i Et Me H HPr-i Et Et H HPr-i Et Pr-n H HPr-i Et Pr-i H HPr-i Pr-n Me H HPr-i Pr-n Et H HPr-i Pr-n Pr-n H HPr-i Pr-n Pr-i H HPr-i Pr-i Me H HPr-i Pr-i Et H HPr-i Pr-i Pr-n H HPr-i Pr-i Pr-i H HMe H Me Me HMe H Me Et HMe H Me Pr-n HMe H Me Pr-i HMe H Et Me HMe H Et Et HMe H Et Pr-n HMe H Et Pr-i HMe H Pr-n Me HMe H Pr-n Et HMe H Pr-n Pr-n HMe H Pr-n Pr-i HMe H Pr-i Me HR1 R2 R3 R4 R5Me H Pr-i Et HMe H Pr-i Pr-n HMe H Pr-i Pr-i HEt H Me Me HEt H Me Et HEt H Me Pr-n HEt H Me Pr-i HEt H Et Me HEt H Et Et HEt H Et Pr-n HEt H Et Pr-i HEt H Pr-n Me HEt H Pr-n Et HEt H Pr-n Pr-n HEt H Pr-n Pr-i HEt H Pr-i Me HEt H Pr-i Et HEt H Pr-i Pr-n HEt H Pr-i Pr-i HPr-n H Me Me HPr-n H Me Et HPr-n H Me Pr-n HPr-n H Me Pr-i HPr-n H Et Me HPr-n H Et Et HPr-n H Et Pr-n HPr-n H Et Pr-i HPr-n H Pr-n Me HPr-n H Pr-n Et HPr-n H Pr-n Pr-n HPr-n H Pr-n Pr-i HPr-n H Pr-i Me HPr-n H Pr-i Et HPr-n H Pr-i Pr-n HPr-n H Pr-i Pr-i HPr-i H Me Me HPr-i H Me Et HPr-i H Me Pr-n HPr-i H Me Pr-i HPr-i H Et Me HR1 R2 R3 R4 R5Pr-i H Et Et HPr-i H Et Pr-n HPr-i H Et Pr-i HPr-i H Pr-n Me HPr-i H Pr-n Et HPr-i H Pr-n Pr-n HPr-i H Pr-n Pr-i HPr-i H Pr-i Me HPr-i H Pr-i Et HPr-i H Pr-i Pr-n HPr-i H Pr-i Pr-i HMe Me H Me HMe Me H Et HMe Me H Pr-n HMe Me H Pr-i HMe Et H Me HMe Et H Et HMe Et H Pr-n HMe Et H Pr-i HMe Pr-n H Me HMe Pr-n H Et HMe Pr-n H Pr-n HMe Pr-n H Pr-i HMe Pr-i H Me HMe Pr-i H Et HMe Pr-i H Pr-n HMe Pr-i H Pr-i HEt Me H Me HEt Me H Et HEt Me H Pr-n HEt Me H Pr-i HEt Et H Me HEt Et H Et HEt Et H Pr-n HEt Et H Pr-i HEt Pr-n H Me HEt Pr-n H Et HEt Pr-n H Pr-n HEt Pr-n H Pr-i HEt Pr-i H Me HR1 R2 R3 R4 R5Et Pr-i H Et HEt Pr-i H Pr-n HEt Pr-i H Pr-i HPr-n Me H Me HPr-n Me H Et HPr-n Me H Pr-n HPr-n Me H Pr-i HPr-n Et H Me HPr-n Et H Et HPr-n Et H Pr-n HPr-n Et H Pr-i HPr-n Pr-n H Me HPr-n Pr-n H Et HPr-n Pr-n H Pr-n HPr-n Pr-n H Pr-i HPr-n Pr-i H Me HPr-n Pr-i H Et HPr-n Pr-i H Pr-n HPr-n Pr-i H Pr-i HPr-i Me H Me HPr-i Me H Et HPr-i Me H Pr-n HPr-i Me H Pr-i HPr-i Et H Me HPr-i Et H Et HPr-i Et H Pr-n HPr-i Et H Pr-i HPr-i Pr-n H Me HPr-i Pr-n H Et HPr-i Pr-n H Pr-n HPr-i Pr-n H Pr-i HPr-i Pr-i H Me HPr-i Pr-i H Et HPr-i Pr-i H Pr-n HPr-i Pr-i H Pr-i HH Me Me Me HH Me Me Et HH Me Me Pr-n HH Me Me Pr-i HH Me Et Me HR1 R2 R3 R4 R5H Me Et Et HH Me Et Pr-n HH Me Et Pr-i HH Me Pr-n Me HH Me Pr-n Et HH Me Pr-n Pr-n HH Me Pr-n Pr-i HH Me Pr-i Me HH Me Pr-i Et HH Me Pr-i Pr-n HH Me Pr-i Pr-i HH Et Me Me HH Et Me Et HH Et Me Pr-n HH Et Me Pr-i HH Et Et Me HH Et Et Et HH Et Et Pr-n HH Et Et Pr-i HH Et Pr-n Me HH Et Pr-n Et HH Et Pr-n Pr-n HH Et Pr-n Pr-i HH Et Pr-i Me HH Et Pr-i Et HH Et Pr-i Pr-n HH Et Pr-i Pr-i HH Pr-n Me Me HH Pr-n Me Et HH Pr-n Me Pr-n HH Pr-n Me Pr-i HH Pr-n Et Me HH Pr-n Et Et HH Pr-n Et Pr-n HH Pr-n Et Pr-i HH Pr-n Pr-n Me HH Pr-n Pr-n Et HH Pr-n Pr-n Pr-n HH Pr-n Pr-n Pr-i HH Pr-n Pr-i Me HR1 R2 R3 R4 R5H Pr-n Pr-i Et HH Pr-n Pr-i Pr-n HH Pr-n Pr-i Pr-i HH Pr-i Me Me HH Pr-i Me Et HH Pr-i Me Pr-n HH Pr-i Me Pr-i HH Pr-i Et Me HH Pr-i Et Et HH Pr-i Et Pr-n HH Pr-i Et Pr-i HH Pr-i Pr-n Me HH Pr-i Pr-n Et HH Pr-i Pr-n Pr-n HH Pr-i Pr-n Pr-i HH Pr-i Pr-i Me HH Pr-i Pr-i Et HH Pr-i Pr-i Pr-n HH Pr-i Pr-i Pr-i HF H H Me HCl H H Me HBr H H Me HI H H Me HCH＝CH2 H H Me HCH2CH＝CH2 H H Me HC≡CH H H Me HCH2C≡CH H H Me HCH2F H H Me HCHF2 H H Me HCN H H Me HNH2 H H Me HNHCOMe H H Me HCH2NH2 H H Me HCH2NHCOMe H H Me HCH2OCHF2 H H Me HCH2OCF3 H H Me HCF3 H H Me HNO2 H H Me HOMe H H Me HR1 R2 R3 R4 R5OPr-n H H Me HSMe H H Me HSEt H H Me HSPr-n H H Me HSBu-n H H Me HSPen-n H H Me HSO2Me H H Me HSO2Et H H Me HSO2Pr-n H H Me HCOMe H H Me HCOEt H H Me HCOPr-n H H Me HCO2H H H Me HCO2Me H H Me HCO2Et H H Me HCO2Pr-n H H Me HCO2Pr-i H H Me HCO2Bu-n H H Me HCO2Bu-t H H Me HCO2Bu-sec H H Me HCO2Pen-n H H Me HCH2Cl H H Me HCH2Br H H Me HCH2I H H Me HCH2CF3 H H Me HCH2CN H H Me HCH2OH H H Me HCH2OMe H H Me HCH2OEt H H Me HCH2OPr-n H H Me HCH2OPr-i H H Me HCH2SMe H H Me HCH2SEt H H Me HCH2SPr-n H H Me HCH2SPr-i H H Me HCH2SO2Me H H Me HCH2SO2Et H H Me HCH2SO2Pr-n H H Me HCH2SO2Pr-i H H Me HCH2COMe H H Me HR1 R2 R3 R4 R5CH2COEt H H Me HCH2COPr-n H H Me HCH2COPr-i H H Me HCH2CO2H H H Me HCH2CO2Me H H Me HCH2CO2Et H H Me HCH2CO2Pr-n H H Me HCH2CO2Pr-i H H Me HCH2OCH2CH＝CH2 H H Me HCH2OCH2C≡CH H H Me HCH＝CHCO2Me H H Me HCH＝CHCO2Et H H Me HCH＝CHCO2Pr-n H H Me HCH＝CHCO2Pr-i H H Me HCH＝CHCN H H Me HPh H H Me HPh-2-F H H Me HPh-3-F H H Me HPh-4-F H H Me HPh-2-Cl H H Me HPh-3-Cl H H Me HPh-4-Cl H H Me HPh-2-Br H H Me HPh-3-Br H H Me HPh-4-Br H H Me HPh-2-CF3 H H Me HPh-3-CF3 H H Me HPh-4-CF3 H H Me HPh-2-Me H H Me HPh-3-Me H H Me HPh-4-Me H H Me HPh-2-Et H H Me HPh-2-OMe H H Me HPh-3-OMe H H Me HPh-4-OMe H H Me HPh-2-OEt H H Me HPh-2-CO2Me H H Me HPh-2-CO2Et H H Me HPh-3-CO2Me H H Me HPh-4-CO2Me H H Me HR1 R2 R3 R4 R5CH2Ph H H Me HCH2Ph-2-F H H Me HCH2Ph-3-F H H Me HCH2Ph-4-F H H Me HCH2Ph-2-Cl H H Me HCH2Ph-3-Cl H H Me HCH2Ph-4-Cl H H Me HCH2Ph-2-Br H H Me HCH2Ph-3-Br H H Me HCH2Ph-4-Br H H Me HCH2Ph-2-CF3 H H Me HCH2Ph-3-CF3 H H Me HCH2Ph-4-CF3 H H Me HCH2Ph-2-Me H H Me HCH2Ph-3-Me H H Me HCH2Ph-4-Me H H Me HCH2Ph-2-Et H H Me HCH2Ph-2-OMe H H Me HCH2Ph-3-OMe H H Me HCH2Ph-4-OMe H H Me HCH2Ph-2-OEt H H Me HCH2Ph-2-CO2Me H H Me HCH2Ph-2-CO2Et H H Me HCH2Ph-3-CO2Me H H Me HCH2Ph-4-CO2Me H H Me HOPh H H Me HOPh-2-Cl H H Me HOPh-3-Cl H H Me HOPh-4-Cl H H Me HOPh-2-F H H Me HOPh-3-F H H Me HOPh-4-F H H Me HOPh-2-CF3 H H Me HOPh-3-CF3 H H Me HOPh-4-CF3 H H Me HOPh-2-Me H H Me HOPh-3-Me H H Me HOPh-4-Me H H Me HOPh-2-Et H H Me HOPh-2-OMe H H Me HR1 R2 R3 R4 R5OPh-3-OMe H H Me HOPh-4-OMe H H Me HOPh-2-OEt H H Me HOPh-2-CO2Me H H Me HOPh-3-CO2Me H H Me HOPh-4-CO2Me H H Me HOPh-2-CO2Et H H Me HSPh H H Me HSPh-2-Cl H H Me HSPh-3-Cl H H Me HSPh-4-Cl H H Me HSPh-2-F H H Me HSPh-3-F H H Me HSPh-4-F H H Me HSPh-2-CF3 H H Me HSPh-3-CF3 H H Me HSPh-4-CF3 H H Me HSPh-2-Me H H Me HSPh-3-Me H H Me HSPh-4-Me H H Me HSPh-2-Et H H Me HSPh-2-OMe H H Me HSPh-3-OMe H H Me HSPh-4-OMe H H Me HSPh-2-OEt H H Me HSPh-2-CO2Me H H Me HSPh-3-CO2Me H H Me HSPh-4-CO2Me H H Me HSPh-4-CO2Et H H Me HSO2Ph H H Me HSO2Ph-2-Cl H H Me HSO2Ph-3-Cl H H Me HSO2Ph-4-Cl H H Me HSO2Ph-2-F H H Me HSO2Ph-3-F H H Me HSO2Ph-4-F H H Me HSO2Ph-2-CF3 H H Me HSO2Ph-3-CF3 H H Me HSO2Ph-4-CF3 H H Me HSO2Ph-2-Me H H Me HR1 R2 R3 R4 R5SO2Ph-3-Me H H Me HSO2Ph-4-Me H H Me HSO2Ph-2-Et H H Me HSO2Ph-2-OMe H H Me HSO2Ph-3-OMe H H Me HSO2Ph-4-OMe H H Me HSO2Ph-2-OEt H H Me HSO2Ph-2-CO2Me H H Me HSO2Ph-3-CO2Me H H Me HSO2Ph-4-CO2Me H H Me HSO2Ph-2-CO2Et H H Me HCONHMe H H Me HCONHEt H H Me HCONHPr-n H H Me HCONHPr-i H H Me HCONHBu-n H H Me HCONHBu-sec H H Me HCONHBu-t H H Me HCON(Me)2 H H Me HCON(Et)2 H H Me HCON(Pr-n)2 H H Me HF H H Et HCl H H Et HBr H H Et HI H H Et HCH＝CH2 H H Et HCH2CH＝CH2 H H Et HC≡CH H H Et HCH2C≡CH H H Et HCH2F H H Et HCHF2 H H Et HCN H H Et HNH2 H H Et HNHCOMe H H Et HCH2NH2 H H Et HCH2NHCOMe H H Et HCH2OCHF2 H H Et HCH2OCF3 H H Et HCF3 H H Et HNO2 H H Et HR1 R2 R3 R4 R5OMe H H Et HOEt H H Et HOPr-n H H Et HSMe H H Et HSEt H H Et HSPr-n H H Et HSBu-n H H Et HSPen-n H H Et HSO2Me H H Et HSO2Et H H Et HSO2Pr-n H H Et HCOMe H H Et HCOEt H H Et HCOPr-n H H Et HCO2H H H Et HCO2Me H H Et HCO2Et H H Et HCO2Pr-n H H Et HCO2Pr-i H H Et HCO2Bu-n H H Et HCO2Bu-t H H Et HCO2Bu-sec H H Et HCO2Pen-n H H Et HCH2Cl H H Et HCH2Br H H Et HCH2I H H Et HCH2CF3 H H Et HCH2CN H H Et HCH2OH H H Et HCH2OMe H H Et HCH2OEt H H Et HCH2OPr-n H H Et HCH2OPr-i H H Et HCH2SMe H H Et HCH2SEt H H Et HCH2SPr-n H H Et HCH2SPr-i H H Et HCH2SO2Me H H Et HCH2SO2Et H H Et HCH2SO2Pr-n H H Et HR1 R2 R3 R4 R5CH2SO2Pr-i H H Et HCH2COMe H H Et HCH2COEt H H Et HCH2COPr-n H H Et HCH2COPr-i H H Et HCH2CO2H H H Et HCH2CO2Me H H Et HCH2CO2Et H H Et HCH2CO2Pr-n H H Et HCH2CO2Pr-i H H Et HCH2OCH2CH＝CH2 H H Et HCH2OCH2C≡CH H H Et HCH＝CHCO2Me H H Et HCH＝CHCO2Et H H Et HCH＝CHCO2Pr-n H H Et HCH＝CHCO2Pr-i H H Et HCH＝CHCN H H Et HPh H H Et HCH2Ph H H Et HOPh H H Et HSPh H H Et HSO2Ph H H Et HCONHMe H H Et HCONHEt H H Et HCONHPr-n H H Et HCONHPr-i H H Et HCONHBu-n H H Et HCONHBu-sec H H Et HCONHBu-t H H Et HCON(Me)2 H H Et HCON(Et)2 H H Et HCON(Pr-n)2 H H Et HF H H Cl HCl H H Cl HBr H H Cl HI H H Cl HCH＝CH2 H H Cl HCH2CH＝CH2 H H Cl HC≡CH H H Cl HCH2C≡CH H H Cl HR1 R2 R3 R4 R5CH2F H H Cl HCHF2 H H Cl HCN H H Cl HNH2 H H Cl HNHCOMe H H Cl HCH2NH2 H H Cl HCH2NHCOMe H H Cl HCH2OCHF2 H H Cl HCH2OCF3 H H Cl HCF3 H H Cl HNO2 H H Cl HOMe H H Cl HOEt H H Cl HOPr-n H H Cl HSMe H H Cl HSEt H H Cl HSPr-n H H Cl HSBu-n H H Cl HSPen-n H H Cl HSO2Me H H Cl HSO2Et H H Cl HSO2Pr-n H H Cl HCOMe H H Cl HCOEt H H Cl HCOPr-n H H Cl HCO2H H H Cl HCO2Me H H Cl HCO2Et H H Cl HCO2Pr-n H H Cl HCO2Pr-i H H Cl HCO2Bu-n H H Cl HCO2Bu-t H H Cl HCO2Bu-sec H H Cl HCO2Pen-n H H Cl HCH2Cl H H Cl HCH2Br H H Cl HCH2I H H Cl HCH2CF3 H H Cl HCH2CN H H Cl HCH2OH H H Cl HR1 R2 R3 R4 R5CH2OMe H H Cl HCH2OEt H H Cl HCH2OPr-n H H Cl HCH2OPr-i H H Cl HCH2SMe H H Cl HCH2SEt H H Cl HCH2SPr-n H H Cl HCH2SPr-i H H Cl HCH2SO2Me H H Cl HCH2SO2Et H H Cl HCH2SO2Pr-n H H Cl HCH2SO2Pr-i H H Cl HCH2COMe H H Cl HCH2COEt H H Cl HCH2COPr-n H H Cl HCH2COPr-i H H Cl HCH2CO2H H H Cl HCH2CO2Me H H Cl HCH2CO2Et H H Cl HCH2CO2Pr-n H H Cl HCH2CO2Pr-i H H Cl HCH2OCH2CH＝CH2 H H Cl HCH2OCH2C≡CH H H Cl HCH＝CHCO2Me H H Cl HCH＝CHCO2Et H H Cl HCH＝CHCO2Pr-n H H Cl HCH＝CHCO2Pr-i H H Cl HCH＝CHCN H H Cl HPh H H Cl HCH2Ph H H Cl HOPh H H Cl HSPh H H Cl HSO2Ph H H Cl HCONHMe H H Cl HCONHEt H H Cl HCONHPr-n H H Cl HCONHPr-i H H Cl HCONHBu-n H H Cl HCONHBu-sec H H Cl HCONHBu-t H H Cl HR1 R2 R3 R4 R5CON(Me)2 H H Cl HCON(Et)2 H H Cl HCON(Pr-n)2 H H Cl HF H H CO2Me HCl H H CO2Me HBr H H CO2Me HI H H CO2Me HCH＝CH2 H H CO2Me HCH2CH＝CH2 H H CO2Me HC≡CH H H CO2Me HCH2C≡CH H H CO2Me HCH2F H H CO2Me HCHF2 H H CO2Me HCN H H CO2Me HNH2 H H CO2Me HNHCOMe H H CO2Me HCH2NH2 H H CO2Me HCH2NHCOMe H H CO2Me HCH2OCHF2 H H CO2Me HCH2OCF3 H H CO2Me HCF3 H H CO2Me HNO2 H H CO2Me HOMe H H CO2Me HOEt H H CO2Me HOPr-n H H CO2Me HSMe H H CO2Me HSEt H H CO2Me HSPr-n H H CO2Me HSBu-n H H CO2Me HSPen-n H H CO2Me HSO2Me H H CO2Me HSO2Et H H CO2Me HSO2Pr-n H H CO2Me HCOMe H H CO2Me HCOEt H H CO2Me HCOPr-n H H CO2Me HCO2H H H CO2Me HCO2Me H H CO2Me HCO2Et H H CO2Me HCO2Pr-n H H CO2Me HR1 R2 R3 R4 R5CO2Pr-i H H CO2Me HCO2Bu-n H H CO2Me HCO2Bu-t H H CO2Me HCO2Bu-sec H H CO2Me HCO2Pen-n H H CO2Me HCH2Cl H H CO2Me HCH2Br H H CO2Me HCH2I H H CO2Me HCH2CF3 H H CO2Me HCH2CN H H CO2Me HCH2OH H H CO2Me HCH2OMe H H CO2Me HCH2OEt H H CO2Me HCH2OPr-n H H CO2Me HCH2OPr-i H H CO2Me HCH2SMe H H CO2Me HCH2SEt H H CO2Me HCH2SPr-n H H CO2Me HCH2SPr-i H H CO2Me HCH2SO2Me H H CO2Me HCH2SO2Et H H CO2Me HCH2SO2Pr-n H H CO2Me HCH2SO2Pr-i H H CO2Me HCH2COMe H H CO2Me HCH2COEt H H CO2Me HCH2COPr-n H H CO2Me HCH2COPr-i H H CO2Me HCH2CO2H H H CO2Me HCH2CO2Me H H CO2Me HCH2CO2Et H H CO2Me HCH2CO2Pr-n H H CO2Me HCH2CO2Pr-i H H CO2Me HCH2OCH2CH＝CH2 H H CO2Me HCH2OCH2C≡CH H H CO2Me HCH＝CHCO2Me H H CO2Me HCH＝CHCO2Et H H CO2Me HCH＝CHCO2Pr-n H H CO2Me HCH＝CHCO2Pr-i H H CO2Me HCH＝CHCN H H CO2Me HPh H H CO2Me HR1 R2 R3 R4 R5CH2Ph H H CO2Me HOPh H H CO2Me HSPh H H CO2Me HSO2Ph H H CO2Me HCONHMe H H CO2Me HCONHEt H H CO2Me HCONHPr-n H H CO2Me HCONHPr-i H H CO2Me HCONHBu-n H H CO2Me HCONHBu-sec H H CO2Me HCONHBu-t H H CO2Me HCON(Me)2 H H CO2Me HCON(Et)2 H H CO2Me HCON(Pr-n)2 H H CO2Me HF H H CH2Cl HCl H H CH2Cl HBr H H CH2Cl HI H H CH2Cl HCH＝CH2 H H CH2Cl HCH2CH＝CH2 H H CH2Cl HC≡CH H H CH2Cl HCH2C≡CH H H CH2Cl HCH2F H H CH2Cl HCHF2 H H CH2Cl HCN H H CH2Cl HNH2 H H CH2Cl HNHCOMe H H CH2Cl HCH2NH2 H H CH2Cl HCH2NHCOMe H H CH2Cl HCH2OCHF2 H H CH2Cl HCH2OCF3 H H CH2Cl HCF3 H H CH2Cl HNO2 H H CH2Cl HOMe H H CH2Cl HOEt H H CH2Cl HOPr-n H H CH2Cl HSMe H H CH2Cl HSEt H H CH2Cl HSPr-n H H CH2Cl HSBu-n H H CH2Cl HR1 R2 R3 R4 R5SPen-n H H CH2Cl HSO2Me H H CH2Cl HSO2Et H H CH2Cl HSO2Pr-n H H CH2Cl HCOMe H H CH2Cl HCOEt H H CH2Cl HCOPr-n H H CH2Cl HCO2H H H CH2Cl HCO2Me H H CH2Cl HCO2Et H H CH2Cl HCO2Pr-n H H CH2Cl HCO2Pr-i H H CH2Cl HCO2Bu-n H H CH2Cl HCO2Bu-t H H CH2Cl HCO2Bu-sec H H CH2Cl HCO2Pen-n H H CH2Cl HCH2Cl H H CH2Cl HCH2Br H H CH2Cl HCH2I H H CH2Cl HCH2CF3 H H CH2Cl HCH2CN H H CH2Cl HCH2OH H H CH2Cl HCH2OMe H H CH2Cl HCH2OEt H H CH2Cl HCH2OPr-n H H CH2Cl HCH2OPr-i H H CH2Cl HCH2SMe H H CH2Cl HCH2SEt H H CH2Cl HCH2SPr-n H H CH2Cl HCH2SPr-i H H CH2Cl HCH2SO2Me H H CH2Cl HCH2SO2Et H H CH2Cl HCH2SO2Pr-n H H CH2Cl HCH2SO2Pr-i H H CH2Cl HCH2COMe H H CH2Cl HCH2COEt H H CH2Cl HCH2COPr-n H H CH2Cl HCH2COPr-i H H CH2Cl HCH2CO2H H H CH2Cl HCH2CO2Me H H CH2Cl HR1 R2 R3 R4 R5CH2CO2Et H H CH2Cl HCH2CO2Pr-n H H CH2Cl HCH2CO2Pr-i H H CH2Cl HCH2OCH2CH＝CH2 H H CH2Cl HCH2OCH2C≡CH H H CH2Cl HCH＝CHCO2Me H H CH2Cl HCH＝CHCO2Et H H CH2Cl HCH＝CHCO2Pr-n H H CH2Cl HCH＝CHCO2Pr-i H H CH2Cl HCH＝CHCN H H CH2Cl HPh H H CH2Cl HCH2Ph H H CH2Cl HOPh H H CH2Cl HSPh H H CH2Cl HSO2Ph H H CH2Cl HCONHMe H H CH2Cl HCONHEt H H CH2Cl HCONHPr-n H H CH2Cl HCONHPr-i H H CH2Cl HCONHBu-n H H CH2Cl HCONHBu-sec H H CH2Cl HCONHBu-t H H CH2Cl HCON(Me)2 H H CH2Cl HCON(Et)2 H H CH2Cl HCON(Pr-n)2 H H CH2Cl HF H H CH2OMe HCl H H CH2OMe HBr H H CH2OMe HI H H CH2OMe HCH＝CH2 H H CH2OMe HCH2CH＝CH2 H H CH2OMe HC≡CH H H CH2OMe HCH2C≡CH H H CH2OMe HCH2F H H CH2OMe HCHF2 H H CH2OMe HCN H H CH2OMe HNH2 H H CH2OMe HNHCOMe H H CH2OMe HCH2NH2 H H CH2OMe HCH2NHCOMe H H CH2OMe HR1 R2 R3 R4 R5CH2OCHF2 H H CH2OMe HCH2OCF3 H H CH2OMe HCF3 H H CH2OMe HNO2 H H CH2OMe HOMe H H CH2OMe HOEt H H CH2OMe HOPr-n H H CH2OMe HSMe H H CH2OMe HSEt H H CH2OMe HSPr-n H H CH2OMe HSBu-n H H CH2OMe HSPen- H H CH2OMe HSO2Me H H CH2OMe HSO2Et H H CH2OMe HSO2Pr-n H H CH2OMe HCOMe H H CH2OMe HCOEt H H CH2OMe HCOPr-n H H CH2OMe HCO2H H H CH2OMe HCO2Me H H CH2OMe HCO2Et H H CH2OMe HCO2Pr-n H H CH2OMe HCO2Pr-i H H CH2OMe HCO2Bu-n H H CH2OMe HCO2Bu-t H H CH2OMe HCO2Bu-sec H H CH2OMe HCO2Pen-n H H CH2OMe HCH2Cl H H CH2OMe HCH2Br H H CH2OMe HCH2I H H CH2OMe HCH2CF3 H H CH2OMe HCH2CN H H CH2OMe HCH2OH H H CH2OMe HCH2OMe H H CH2OMe HCH2OEt H H CH2OMe HCH2OPr-n H H CH2OMe HCH2OPr-i H H CH2OMe HCH2SMe H H CH2OMe HCH2SEt H H CH2OMe HCH2SPr-n H H CH2OMe HR1 R2 R3 R4 R5CH2SPr-i H H CH2OMe HCH2SO2Me H H CH2OMe HCH2SO2Et H H CH2OMe HCH2SO2Pr-n H H CH2OMe HCH2SO2Pr-i H H CH2OMe HCH2COMe H H CH2OMe HCH2COEt H H CH2OMe HCH2COPr-n H H CH2OMe HCH2COPr-i H H CH2OMe HCH2CO2H H H CH2OMe HCH2CO2Me H H CH2OMe HCH2CO2Et H H CH2OMe HCH2CO2Pr-n H H CH2OMe HCH2CO2Pr-i H H CH2OMe HCH2OCH2CH＝CH2 H H CH2OMe HCH2OCH2C≡CH H H CH2OMe HCH＝CHCO2Me H H CH2OMe HCH＝CHCO2Et H H CH2OMe HCH＝CHCO2Pr-n H H CH2OMe HCH＝CHCO2Pr-i H H CH2OMe HCH＝CHCN H H CH2OMe HPh H H CH2OMe HCH2Ph H H CH2OMe HOPh H H CH2OMe HSPh H H CH2OMe HSO2Ph H H CH2OMe HCONHMe H H CH2OMe HCONHEt H H CH2OMe HCONHPr-n H H CH2OMe HCONHPr-i H H CH2OMe HCONHBu-n H H CH2OMe HCONHBu-sec H H CH2OMe HCONHBu-t H H CH2OMe HCON(Me)2 H H CH2OMe HCON(Et)2 H H CH2OMe HCON(Pr-n)2 H H CH2OMe HF H H CH2SMe HCl H H CH2SMe HBr H H CH2SMe HI H H CH2SMe HR1 R2 R3 R4 R5CH＝CH2 H H CH2SMe HCH2CH＝CH2 H H CH2SMe HC≡CH H H CH2SMe HCH2C≡CH H H CH2SMe HCH2F H H CH2SMe HCHF2 H H CH2SMe HCN H H CH2SMe HNH2 H H CH2SMe HNHCOMe H H CH2SMe HCH2NH2 H H CH2SMe HCH2NHCOMe H H CH2SMe HCH2OCHF2 H H CH2SMe HCH2OCF3 H H CH2SMe HCF2 H H CH2SMe HNO2 H H CH2SMe HOMe H H CH2SMe HOEt H H CH2SMe HOPr-n H H CH2SMe HSMe H H CH2SMe HSEt H H CH2SMe HSPr-n H H CH2SMe HSBu-n H H CH2SMe HSPen-n H H CH2SMe HSO2Me H H CH2SMe HSO2Et H H CH2SMe HSO2Pr-l H H CH2SMe HCOMe H H CH2SMe HCOEt H H CH2SMe HCOPr-n H H CH2SMe HCO2H H H CH2SMe HCO2Me H H CH2SMe HCO2Et H H CH2SMe HCO2Pr-n H H CH2SMe HCO2Pr-i H H CH2SMe HCO2Bu-n H H CH2SMe HCO2Bu-t H H CH2SMe HCO2Bu-sec H H CH2SMe HCO2Pen-n H H CH2SMe HCH2Cl H H CH2SMe HCH2Br H H CH2SMe HR1 R2 R3 R4 R5CH2I H H CH2SMe HCH2CF3 H H CH2SMe HCH2CN H H CH2SMe HCH2OH H H CH2SMe HCH2OMe H H CH2SMe HCH2OEt H H CH2SMe HCH2OPr-n H H CH2SMe HCH2OPr-i H H CH2SMe HCH2SMe H H CH2SMe HCH2SEt H H CH2SMe HCH2SPr-n H H CH2SMe HCH2SPr-i H H CH2SMe HCH2SO2Me H H CH2SMe HCH2SO2Et H H CH2SMe HCH2SO2Pr-n H H CH2SMe HCH2SO2Pr-i H H CH2SMe HCH2COMe H H CH2SMe HCH2COEt H H CH2SMe HCH2COPr-n H H CH2SMe HCH2COPr-i H H CH2SMe HCH2CO2H H H CH2SMe HCH2CO2Me H H CH2SMe HCH2CO2Et H H CH2SMe HCH2CO2Pr-n H H CH2SMe HCH2CO2Pr-i H H CH2SMe HCH2OCH2CH＝CH2 H H CH2SMe HCH2OCH2C≡CH H H CH2SMe HCH＝CHCO2Me H H CH2SMe HCH＝CHCO2Et H H CH2SMe HCH＝CHCO2Pr-n H H CH2SMe HCH＝CHCO2Pr-i H H CH2SMe HCH＝CHCN H H CH2SMe HPh H H CH2SMe HCH2Ph H H CH2SMe HOPh H H CH2SMe HSPh H H CH2SMe HSO2Ph H H CH2SMe HCONHMe H H CH2SMe HCONHEt H H CH2SMe HCONHPr-n H H CH2SMe HR1 R2 R3 R4 R5CONHPr-i H H CH2SMe HCONHBu-n H H CH2SMe HCONHBu-sec H H CH2SMe HCONHBu-t H H CH2SMe HCON(Me)2 H H CH2SMe HCON(Et)2 H H CH2SMe HCON(Pr-n)2 H H CH2SMe HF H H CN HCl H H CN HBr H H CN HI H H CN HCH＝CH2 H H CN HCH2CH＝CH2 H H CN HC≡CH H H CN HCH2C≡CH H H CN HCH2F H H CN HCHF2 H H CN HCN H H CN HNH2 H H CN HNHCOMe H H CN HCH2NH2 H H CN HCH2NHCOMe H H CN HCH2OCHF2 H H CN HCH2OCF3 H H CN HCF3 H H CN HNO2 H H CN HOMe H H CN HOEt H H CN HOPr-n H H CN HSMe H H CN HSEt H H CN HSPr-n H H CN HSBu-n H H CN HSPen-n H H CN HSO2Me H H CN HSO2Et H H CN HSO2Pr-n H H CN HCOMe H H CN HCOEt H H CN HCOPr-n H H CN HR1 R2 R3 R4 R5CO2H H H CN HCO2Me H H CN HCO2Et H H CN HCO2Pr-n H H CN HCO2Pr-i H H CN HCO2Bu-n H H CN HCO2Bu-t H H CN HCO2Bu-sec H H CN HCO2Pen-n H H CN HCH2Cl H H CN HCH2Br H H CN HCH2I H H CN HCH2CF3 H H CN HCH2CN H H CN HCH2OH H H CN HCH2OMe H H CN HCH2OEt H H CN HCH2OPr-n H H CN HCH2OPr-i H H CN HCH2SMe H H CN HCH2SEt H H CN HCH2SPr-n H H CN HCH2SPr-i H H CN HCH2SO2Me H H CN HCH2SO2Et H H CN HCH2SO2Pr-n H H CN HCH2SO2Pr-i H H CN HCH2COMe H H CN HCH2COEt H H CN HCH2COPr-n H H CN HCH2COPr-i H H CN HCH2CO2H H H CN HCH2CO2Me H H CN HCH2CO2Et H H CN HCH2CO2Pr-n H H CN HCH2CO2Pr-i H H CN HCH2OCH2CH＝CH2 H H CN HCH2OCH2C≡CH H H CN HCH＝CHCO2Me H H CN HCH＝CHCO2Et H H CN HR1 R2 R3 R4 R5CH＝CHCO2Pr-n H H CN HCH＝CHCO2Pr-i H H CN HCH＝CHCN H H CN HPh H H CN HCH2Ph H H CN HOPh H H CN HSPh H H CN HSO2Ph H H CN HCONHMe H H CN HCONHEt H H CN HCONHPr-n H H CN HCONHPr-i H H CN HCONHBu-n H H CN HCONHBu-sec H H CN HCONHBu-t H H CN HCON(Me)2 H H CN HCON(Et)2 H H CN HCON(Pr-n)2 H H CN HR4 R3 R2 R1 R5F H H Me HCl H H Me HBr H H Me HI H H Me HCH＝CH2 H H Me HCH2CH＝CH2 H H Me HC≡CH H H Me HCH2C≡CH H H Me HCH2F H H Me HCHF2 H H Me HCN H H Me HNH2 H H Me HNHCOMe H H Me HCH2NH2 H H Me HCH2NHCOMe H H Me HCH2OCHF2 H H Me HCH2OCF3 H H Me HCF3 H H Me HNO2 H H Me HOMe H H Me HOEt H H Me HOPr-n H H Me HSMe H H Me HSEt H H Me HSPr-n H H Me HSBu-n H H Me HSPen-n H H Me HSO2Me H H Me HSO2Et H H Me HSO2Pr-n H H Me HCOMe H H Me HCOEt H H Me HCOPr-n H H Me HCO2H H H Me HCO2Me H H Me HCO2Et H H Me HCO2Pr-n H H Me HCO2Pr-i H H Me HCO2Bu-n H H Me HCO2Bu-t H H Me HR4 R3 R2 R1 R5CO2Bu-sec H H Me HCO2Pen-n H H Me HCH2Cl H H Me HCH2Br H H Me HCH2I H H Me HCH2CF3 H H Me HCH2CN H H Me HCH2OH H H Me HCH2OMe H H Me HCH2OEt H H Me HCH2OPr-n H H Me HCH2OPr-i H H Me HCH2SMe H H Me HCH2SEt H H Me HCH2SPr-n H H Me HCH2SPr-i H H Me HCH2SO2Me H H Me HCH2SO2Et H H Me HCH2SO2Pr-n H H Me HCH2SO2Pr-i H H Me HCH2COMe H H Me HCH2COEt H H Me HCH2COPr-n H H Me HCH2COPr-i H H Me HCH2CO2H H H Me HCH2CO2Me H H Me HCH2CO2Et H H Me HCH2CO2Pr-n H H Me HCH2CO2Pr-i H H Me HCH2OCH2CH＝CH2 H H Me HCH2OCH2C≡CH H H Me HCH＝CHCO2Me H H Me HCH＝CHCO2Et H H Me HCH＝CHCO2Pr-n H H Me HCH＝CHCO2Pr-i H H Me HCH＝CHCN H H Me HPh H H Me HPh-2-F H H Me HPh-3-F H H Me HPh-4-F H H Me HR4 R3 R2 R1 R5Ph-2-Cl H H Me HPh-3-Cl H H Me HPh-4-Cl H H Me HPh-2-Br H H Me HPh-3-Br H H Me HPh-4-Br H H Me HPh-2-CF3 H H Me HPh-3-CF3 H H Me HPh-4-CF3 H H Me HPh-2-Me H H Me HPh-3-Me H H Me HPh-4-Me H H Me HPh-2-Et H H Me HPh-2-OMe H H Me HPh-3-OMe H H Me HPh-4-OMe H H Me HPh-2-OEt H H Me HPh-2-CO2Me H H Me HPh-2-CO2Et H H Me HPh-3-CO2Me H H Me HPh-4-CO2Me H H Me HCH2Ph H H Me HCH2Ph-2-F H H Me HCH2Ph-3-F H H Me HCH2Ph-4-F H H Me HCH2Ph-2-Cl H H Me HCH2Ph-3-Cl H H Me HCH2Ph-4-Cl H H Me HCH2Ph-2-Br H H Me HCH2Ph-3-Br H H Me HCH2Ph-4-Br H H Me HCH2Ph-2-CF3 H H Me HCH2Ph-3-CF3 H H Me HCH2Ph-4-CF3 H H Me HCH2Ph-2-Me H H Me HCH2Ph-3-Me H H Me HCH2Ph-4-Me H H Me HCH2Ph-2-Et H H Me HCH2Ph-2-OMe H H Me HCH2Ph-3-OMe H H Me HR4 R3 R2 R1 R5CH2Ph-4-OMe H H Me HCH2Ph-2-OEt H H Me HCH2Ph-2-CO2Me H H Me HCH2Ph-2-CO2Et H H Me HCH2Ph-3-CO2Me H H Me HCH2Ph-4-CO2Me H H Me HOPh H H Me HOPh-2-Cl H H Me HOPh-3-Cl H H Me HOPh-4-Cl H H Me HOPh-2-F H H Me HOPh-3-F H H Me HOPh-4-F H H Me HOPh-2-CF3 H H Me HOPh-3-CF3 H H Me HOPh-4-CF3 H H Me HOPh-2-Me H H Me HOPh-3-Me H H Me HOPh-4-Me H H Me HOPh-2-Et H H Me HOPh-2-OMe H H Me HOPh-3-OMe H H Me HOPh-4-OMe H H Me HOPh-2-OEt H H Me HOPh-2-CO2Me H H Me HOPh-3-CO2Me H H Me HOPh-4-CO2Me H H Me HOPh-2-CO2Et H H Me HSPh H H Me HSPh-2-CI H H Me HSPh-3-CI H H Me HSPh-4-CI H H Me HSPh-2-F H H Me HSPh-3-F H H Me HSPh-4-F H H Me HSPh-2-CF3 H H Me HSPh-3-CF3 H H Me HSPh-4-CF3 H H Me HSPh-2-Me H H Me HSPh-3-Me H H Me HR4 R3 R2 R1 R5SPh-4-Me H H Me HSPh-2-Et H H Me HSPh-2-OMe H H Me HSPh-3-OMe H H Me HSPh-4-OMe H H Me HSPh-2-OEt H H Me HSPh-2-CO2Me H H Me HSPh-3-CO2Me H H Me HSPh-4-CO2Me H H Me HSPh-4-CO2Et H H Me HSO2Ph H H Me HSO2Ph-2-Cl H H Me HSO2Ph-3-Cl H H Me HSO2Ph-4-Cl H H Me HSO2Ph-2-F H H Me HSO2Ph-3-F H H Me HSO2Ph-4-F H H Me HSO2Ph-2-CF3 H H Me HSO2Ph-3-CF3 H H Me HSO2Ph-4-CF3 H H Me HSO2Ph-2-Me H H Me HSO2Ph-3-Me H H Me HSO2Ph-4-Me H H Me HSO2Ph-2-Et H H Me HSO2Ph-2-OMe H H Me HSO2Ph-3-OMe H H Me HSO2Ph-4-OMe H H Me HSO2Ph-2-OEt H H Me HSO2Ph-2-CO2Me H H Me HSO2Ph-3-CO2Me H H Me HSO2Ph-4-CO2Me H H Me HSO2Ph-2-CO2Et H H Me HCONHMe H H Me HCONHEt H H Me HCONHPr-n H H Me HCONHPr-i H H Me HCONHBu-n H H Me HCONHBu-sec H H Me HCONHBu-t H H Me HCON(Me)2 H H Me HR4 R3 R2 R1 R5CON(Et)2 H H Me HCON(Pr-n)2 H H Me HF H H Et HCl H H Et HBr H H Et HI H H Et HCH＝CH2 H H Et HCH2CH＝CH2 H H Et HC≡CH H H Et HCH2C≡CH H H Et HCHH2F H H Et HCHF2 H H Et HCN H H Et HNH2 H H Et HNHCOMe H H Et HCH2NH2 H H Et HCH2NHCOMe H H Et HCH2OCHF2 H H Et HCH2OCF3 H H Et HCF3 H H Et HNO2 H H Et HOMe H H Et HOEt H H Et HOPr-n H H Et HSMe H H Et HSEt H H Et HSPr-n H H Et HSBu-n H H Et HSPen-n H H Et HSO2Me H H Et HSO2Et H H Et HSO2Pr-n H H Et HCOMe H H Et HCOEt H H Et HCOPr-n H H Et HCO2H H H Et HCO2Me H H Et HCO2Et H H Et HCO2Pr-n H H Et HCO2Pr-i H H Et HR4 R3 R2 R1 R5CO2Bu-n H H Et HCO2Bu-t H H Et HCO2Bu-sec H H Et HCO2Pen-n H H Et HCH2Cl H H Et HCH2Br H H Et HCH2I H H Et HCH2CF3 H H Et HCH2CN H H Et HCH2OH H H Et HCH2OMe H H Et HCH2OEt H H Et HCH2OPr-n H H Et HCH2OPr-i H H Et HCH2SMe H H Et HCH2SEt H H Et HCH2SPr-n H H Et HCH2SPr-i H H Et HCH2SO2Me H H Et HCH2SO2Et H H Et HCH2SO2Pr-n H H Et HCH2SO2Pr-i H H Et HCH2COMe H H Et HCH2COEt H H Et HCH2COPr-n H H Et HCH2COPr-i H H Et HCH2CO2H H H Et HCH2CO2Me H H Et HCH2CO2Et H H Et HCH2CO2Pr-n H H Et HCH2CO2Pr-i H H Et HCH2OCH2CH＝CH2 H H Et HCH2OCH2C≡CH H H Et HCH＝CHCO2Me H H Et HCH＝CHCO2Et H H Et HCH＝CHCO2Pr-n H H Et HCH＝CHCO2Pr-i H H Et HCH＝CHCN H H Et HPh H H Et HCH2Ph H H Et HR4 R3 R2 R1 R5OPh H H Et HSPh H H Et HSO2Ph H H Et HCONHMe H H Et HCONHEt H H Et HCONHPr-n H H Et HCONHPr-i H H Et HCONHBu-n H H Et HCONHBu-sec H H Et HCONHBu-t H H Et HCON(Me)2 H H Et HCON(Et)2 H H Et HCON(Pr-n)2 H H Et HF H H Cl HCl H H Cl HBr H H Cl HI H H Cl HCH＝CH2 H H Cl HCH2CH＝CH2 H H Cl HC≡CH H H Cl HCH2C≡CH H H Cl HCH2F H H Cl HCHF2 H H Cl HCN H H Cl HNH2 H H Cl HNHCOMe H H Cl HCH2NH2 H H Cl HCH2NHCOMe H H Cl HCH2OCHF2 H H Cl HCH2OCF3 H H Cl HCF3 H H Cl HNO2 H H Cl HOMe H H Cl HOEt H H Cl HOPr-n H H Cl HSMe H H Cl HSEt H H Cl HSPr-n H H Cl HSBu-n H H Cl HSPen-n H H Cl HR4 R3 R2 R1 R5SO2Me H H Cl HSO2Et H H Cl HSO2Pr-n H H Cl HCOMe H H Cl HCOEt H H Cl HCOPr-n H H Cl HCO2H H H Cl HCO2Me H H Cl HCO2Et H H Cl HCO2Pr-n H H Cl HCO2Pr-i H H Cl HCO2Bu-n H H Cl HCO2Bu-t H H Cl HCO2Bu-sec H H Cl HCO2Pen-n H H Cl HCH2Cl H H Cl HCH2Br H H Cl HCH2I H H Cl HCH2CF3 H H Cl HCH2CN H H Cl HCH2OH H H Cl HCH2OMe H H Cl HCH2OEt H H Cl HCH2OPr-n H H Cl HCH2OPr-i H H Cl HCH2SMe H H Cl HCH2SEt H H Cl HCH2SPr-n H H Cl HCH2SPr-i H H Cl HCH2SO2Me H H Cl HCH2SO2Et H H Cl HCH2SO2Pr-n H H Cl HCH2SO2Pr-i H H Cl HCH2COMe H H Cl HCH2COEt H H Cl HCH2COPr-n H H Cl HCH2COPr-i H H Cl HCH2CO2H H H Cl HCH2CO2Me H H Cl HCH2CO2Et H H Cl HR4 R3 R2 R1 R5CH2CO2Pr-n H H Cl HCH2CO2Pr-i H H Cl HCH2OCH2CH＝CH2 H H Cl HCH2OCH2C≡CH H H Cl HCH＝CHCO2Me H H Cl HCH＝CHCO2Et H H Cl HCH＝CHCO2Pr-n H H Cl HCH＝CHCO2Pr-i H H Cl HCH＝CHCN H H Cl HPh H H Cl HCH2Ph H H Cl HOPh H H Cl HSPh H H Cl HSO2Ph H H Cl HCONHMe H H Cl HCONHEt H H Cl HCONHPr-n H H Cl HCONHPr-i H H Cl HCONHBu-n H H Cl HCONHBu-sec H H Cl HCONHBu-t H H Cl HCON(Me)2 H H Cl HCON(Et)2 H H Cl HCON(Pr-n)2 H H Cl HF H H CO2Me HCl H H CO2Me HBr H H CO2Me HI H H CO2Me HCH＝CH2 H H CO2Me HCH2CH＝CH2 H H CO2Me HC≡CH H H CO2Me HCH2C≡CH H H CO2Me HCH2F H H CO2Me HCHF2 H H CO2Me HCN H H CO2Me HNH2 H H CO2Me HNHCOMe H H CO2Me HCH2NH2 H H CO2Me HCH2NHCOMe H H CO2Me HCH2OCHF2 H H CO2Me HR4 R3 R2 R1 R5CH2OCF3 H H CO2Me HCF3 H H CO2Me HNO2 H H CO2Me HOMe H H CO2Me HOEt H H CO2Me HOPr-n H H CO2Me HSMe H H CO2Me HSEt H H CO2Me HSPr-n H H CO2Me HSBu-n H H CO2Me HSPen-n H H CO2Me HSO2Me H H CO2Me HSO2Et H H CO2Me HSO2Pr-n H H CO2Me HCOMe H H CO2Me HCOEt H H CO2Me HCOPr-n H H CO2Me HCO2H H H CO2Me HCO2Me H H CO2Me HCO2Et H H CO2Me HCO2Pr-n H H CO2Me HCO2Pr-i H H CO2Me HCO2Bu-n H H CO2Me HCO2Bu-t H H CO2Me HCO2Bu-sec H H CO2Me HCO2Pen-n H H CO2Me HCH2Cl H H CO2Me HCH2Br H H CO2Me HCH2I H H CO2Me HCH2CF3 H H CO2Me HCH2CN H H CO2Me HCH2OH H H CO2Me HCH2OMe H H CO2Me HCH2OEt H H CO2Me HCH2OPr-n H H CO2Me HCH2OPr-i H H CO2Me HCH2SMe H H CO2Me HCH2SEt H H CO2Me HCH2SPr-n H H CO2Me HCH2SPr-i H H CO2Me HR4 R3 R2 R1 R5CH2SO2Me H H CO2Me HCH2SO2Et H H CO2Me HCH2SO2Pr-n H H CO2Me HCH2SO2Pr-i H H CO2Me HCH2COMe H H CO2Me HCH2COEt H H CO2Me HCH2COPr-n H H CO2Me HCH2COPr-i H H CO2Me HCH2CO2H H H CO2Me HCH2CO2Me H H CO2Me HCH2CO2Et H H CO2Me HCH2CO2Pr-n H H CO2Me HCH2CO2Pr-i H H CO2Me HCH2OCH2CH＝CH2 H H CO2Me HCH2OCH2C≡CH H H CO2Me HCH＝CHCO2Me H H CO2Me HCH＝CHCO2Et H H CO2Me HCH＝CHCO2Pr-n H H CO2Me HCH＝CHCO2Pr-i H H CO2Me HCH＝CHCN H H CO2Me HPh H H CO2Me HCH2Ph H H CO2Me HOPh H H CO2Me HSPh H H CO2Me HSO2Ph H H CO2Me HCONHMe H H CO2Me HCONHEt H H CO2Me HCONHPr-n H H CO2Me HCONHPr-i H H CO2Me HCONHBu-n H H CO2Me HCONHBu-sec H H CO2Me HCONHBu-t H H CO2Me HCON(Me)2 H H CO2Me HCON(Et)2 H H CO2Me HCON(Pr-n)2 H H CO2Me HF H H CH2Cl HCl H H CH2Cl HBr H H CH2Cl HI H H CH2Cl HCH＝CH2 H H CH2Cl HR4 R3 R2 R1 R5CH2CH＝CH2 H H CH2Cl HC≡CH H H CH2Cl HCH2C≡CH H H CH2Cl HCH2F H H CH2Cl HCHF2 H H CH2Cl HCN H H CH2Cl HNH2 H H CH2Cl HNHCOMe H H CH2Cl HCH2NH2 H H CH2Cl HCH2NHCOMe H H CH2Cl HCH2OCHF2 H H CH2Cl HCH2OCF3 H H CH2Cl HCF3 H H CH2Cl HNO2 H H CH2Cl HOMe H H CH2Cl HOEt H H CH2Cl HOPr-n H H CH2Cl HSMe H H CH2Cl HSEt H H CH2Cl HSPr-n H H CH2Cl HSBu-n H H CH2Cl HSPen-n H H CH2Cl HSO2Me H H CH2Cl HSO2Et H H CH2Cl HSO2Pr-n H H CH2Cl HCOMe H H CH2Cl HCOEt H H CH2Cl HCOPr-n H H CH2Cl HCO2H H H CH2Cl HCO2Me H H CH2Cl HCO2Et H H CH2Cl HCO2Pr-n H H CH2Cl HCO2Pr-i H H CH2Cl HCO2Bu-n H H CH2Cl HCO2Bu-t H H CH2Cl HCO2Bu-sec H H CH2Cl HCO2Pen-n H H CH2Cl HCH2Cl H H CH2Cl HCH2Br H H CH2Cl HCH2I H H CH2Cl HR4 R3 R2 R1 R5CH2CF3 H H CH2Cl HCH2CN H H CH2Cl HCH2OH H H CH2Cl HCH2OMe H H CH2Cl HCH2OEt H H CH2Cl HCH2OPr-n H H CH2Cl HCH2OPr-i H H CH2Cl HCH2SMe H H CH2Cl HCH2SEt H H CH2Cl HCH2SPr-n H H CH2Cl HCH2SPr-i H H CH2Cl HCH2SO2Me H H CH2Cl HCH2SO2Et H H CH2Cl HCH2SO2Pr-n H H CH2Cl HCH2SO2Pr-i H H CH2Cl HCH2COMe H H CH2Cl HCH2COEt H H CH2Cl HCH2COPr-n H H CH2Cl HCH2COPr-i H H CH2Cl HCH2CO2H H H CH2Cl HCH2CO2Me H H CH2Cl HCH2CO2Et H H CH2Cl HCH2CO2Pr-n H H CH2Cl HCH2CO2Pr-i H H CH2Cl HCH2OCH2CH＝CH2 H H CH2Cl HCH2OCH2C≡CH H H CH2Cl HCH＝CHCO2Me H H CH2Cl HCH＝CHCO2Et H H CH2Cl HCH＝CHCO2Pr-n H H CH2Cl HCH＝CHCO2Pr-i H H CH2Cl HCH＝CHCN H H CH2Cl HPh H H CH2Cl HCH2Ph H H CH2Cl HOPh H H CH2Cl HSPh H H CH2Cl HSO2Ph H H CH2Cl HCONHMe H H CH2Cl HCONHEt H H CH2Cl HCONHPr-n H H CH2Cl HCONHPr-i H H CH2Cl HR4 R3 R2 R1 R5CONHBu-n H H CH2Cl HCONHBu-sec H H CH2Cl HCONHBu-t H H CH2Cl HCON(Me)2 H H CH2Cl HCON(Et)2 H H CH2Cl HCON(Pr-n)2 H H CH2Cl HF H H CH2OMe HCl H H CH2OMe HBr H H CH2OMe HI H H CH2OMe HCH＝CH2 H H CH2OMe HCH2CH＝CH2 H H CH2OMe HC≡CH H H CH2OMe HCH2C≡CH H H CH2OMe HCH2F H H CH2OMe HCHF2 H H CH2OMe HCN H H CH2OMe HNH2 H H CH2OMe HNHCOMe H H CH2OMe HCH2NH2 H H CH2OMe HCH2NHCOMe H H CH2OMe HCH2OCHF2 H H CH2OMe HCH2OCF3 H H CH2OMe HCF3 H H CH2OMe HNO2 H H CH2OMe HOMe H H CH2OMe HOEt H H CH2OMe HOPr-n H H CH2OMe HSMe H H CH2OMe HSEt H H CH2OMe HSPr-n H H CH2OMe HSBu-n H H CH2OMe HSPen-n H H CH2OMe HSO2Me H H CH2OMe HSO2Et H H CH2OMe HSO2Pr-n H H CH2OMe HCOMe H H CH2OMe HCOEt H H CH2OMe HCOPr-n H H CH2OMe HCO2H H H CH2OMe HR4 R3 R2 R1 R5CO2Pen-n H H CH2OMe HCH2Cl H H CH2OMe HCH2Br H H CH2OMe HCH2I H H CH2OMe HCH2CF3 H H CH2OMe HCH2CN H H CH2OMe HCH2OH H H CH2OMe HCH2OMe H H CH2OMe HCH2OEt H H CH2OMe HCH2OPr-n H H CH2OMe HCH2OPr-i H H CH2OMe HCH2SMe H H CH2OMe HCH2SEt H H CH2OMe HCH2SPr-n H H CH2OMe HCH2SPr-i H H CH2OMe HCH2SO2Me H H CH2OMe HCH2SO2Et H H CH2OMe HCH2SO2Pr-n H H CH2OMe HCH2SO2Pr-i H H CH2OMe HCH2COMe H H CH2OMe HCH2COEt H H CH2OMe HCH2COPr-n H H CH2OMe HCH2COPr-i H H CH2OMe HCH2CO2H H H CH2OMe HCH2CO2Me H H CH2OMe HCH2CO2Et H H CH2OMe HCH2CO2Pr-n H H CH2OMe HCH2CO2Pr-i H H CH2OMe HCH2OCH2CH＝CH2 H H CH2OMe HCH2OCH2C≡CH H H CH2OMe HCH＝CHCO2Me H H CH2OMe HCH＝CHCO2Et H H CH2OMe HCH＝CHCO2Pr-n H H CH2OMe HR4 R3 R2 R1 R5CH＝CHCO2Pr-i H H CH2OMe HCH＝CHCN H H CH2OMe HPh H H CH2OMe HCH2Ph H H CH2OMe HOPh H H CH2OMe HSPh H H CH2OMe HSO2Ph H H CH2OMe HCONHMe H H CH2OMe HCONHEt H H CH2OMe HCONHPr-n H H CH2OMe HCONHPr-i H H CH2OMe HCONHBu-n H H CH2OMe HCONHBu-sec H H CH2OMe HCONHBu-t H H CH2OMe HCON(Me)2 H H CH2OMe HCON(Et)2 H H CH2OMe HCON(Pr-n)2 H H CH2OMe HF H H CH2SMe HCl H H CH2SMe HBr H H CH2SMe HI H H CH2SMe HCH＝CH2 H H CH2SMe HCH2CH＝CH2 H H CH2SMe HC≡CH H H CH2SMe HCH2C≡CH H H CH2SMe HCH2F H H CH2SMe HCHF2 H H CH2SMe HCN H H CH2SMe HNH2 H H CH2SMe HNHCOMe H H CH2SMe HCH2NH2 H H CH2SMe HCH2NHCOMe H H CH2SMe HCH2OCHF2 H H CH2SMe HCH2OCF3 H H CH2SMe HCF3 H H CH2SMe HNO2 H H CH2SMe HOMe H H CH2SMe HOEt H H CH2SMe HOPr-n H H CH2SMe HSMe H H CH2SMe HR4 R3 R2 R1 R5SEt H H CH2SMe HSPr-n H H CH2SMe HSBu-n H H CH2SMe HSPen-n H H CH2SMe HSO2Me H H CH2SMe HSO2Et H H CH2SMe HSO2Pr-n H H CH2SMe HCOMe H H CH2SMe HCOEt H H CH2SMe HCOPr-n H H CH2SMe HCO2H H H CH2SMe HCO2Me H H CH2SMe HCO2Et H H CH2SMe HCO2Pr-n H H CH2SMe HCO2Pr-i H H CH2SMe HCO2Bu-n H H CH2SMe HCO2Bu-t H H CH2SMe HCO2Bu-sec H H CH2SMe HCO2Pen-n H H CH2SMe HCH2Cl H H CH2SMe HCH2Br H H CH2SMe HCH2I H H CH2SMe HCH2CF3 H H CH2SMe HCH2CN H H CH2SMe HCH2OH H H CH2SMe HCH2OMe H H CH2SMe HCH2OEt H H CH2SMe HCH2OPr-n H H CH2SMe HCH2OPr-i H H CH2SMe HCH2SMe H H CH2SMe HCH2SEt H H CH2SMe HCH2SPr-n H H CH2SMe HCH2SPr-i H H CH2SMe HCH2SO2Me H H CH2SMe HCH2SO2Et H H CH2SMe HCH2SO2Pr-n H H CH2SMe HCH2SO2Pr-i H H CH2SMe HCH2COMe H H CH2SMe HCH2COEt H H CH2SMe HCH2COPr-n H H CH2SMe HR4 R3 R2 R1 R5CH2COPr-i H H CH2SMe HCH2CO2H H H CH2SMe HCH2CO2Me H H CH2SMe HCH2CO2Et H H CH2SMe HCH2CO2Pr-n H H CH2SMe HCH2CO2Pr-i H H CH2SMe HCH2OCH2CH＝CH2 H H CH2SMe HCH2OCH2C≡CH H H CH2SMe HCH＝CHCO2Me H H CH2SMe HCH＝CHCO2Et H H CH2SMe HCH＝CHCO2Pr-n H H CH2SMe HCH＝CHCO2Pr-i H H CH2SMe HCH＝CHCN H H CH2SMe HPh H H CH2SMe HCH2Ph H H CH2SMe HOPh H H CH2SMe HSPh H H CH2SMe HSO2Ph H H CH2SMe HCONHMe H H CH2SMe HCONHEt H H CH2SMe HCONHPr-n H H CH2SMe HCONHPr-i H H CH2SMe HCONHBu-n H H CH2SMe HCONHBu-sec H H CH2SMe HCONHBu-t H H CH2SMe HCON(Me)2 H H CH2SMe HCON(Et)2 H H CH2SMe HCON(Pr-n)2 H H CH2SMe HF H H CN HCl H H CN HBr H H CN HI H H CN HCH＝CH2 H H CN HCH2CH＝CH2 H H CN HC≡CH H H CN HCH2C≡CH H H CN HCH2F H H CN HCHF2 H H CN HCN H H CN HNH2 H H CN HR4 R3 R2 R1 R5NHCOMe H H CN HCH2NH2 H H CN HCH2NHCOMe H H CN HCH2OCHF2 H H CN HCH2OCF3 H H CN HCF3 H H CN HNO2 H H CN HOMe H H CN HOEt H H CN HOPr-n H H CN HSMe H H CN HSEt H H CN HSPr-n H H CN HSBu-n H H CN HSPen-n H H CN HSO2Me H H CN HSO2Et H H CN HSO2Pr-n H H CN HCOMe H H CN HCOEt H H CN HCOPr-n H H CN HCO2H H H CN HCO2Me H H CN HCO2Et H H CN HCO2Pr-n H H CN HCO2Pr-i H H CN HCO2Bu-n H H CN HCO2Bu-t H H CN HCO2Bu-sec H H CN HCO2Pen-n H H CN HCH2Cl H H CN HCH2Br H H CN HCH2I H H CN HCH2CF3 H H CN HCH2CN H H CN HCH2OH H H CN HCH2OMe H H CN HCH2OEt H H CN HCH2OPr-n H H CN HCH2OPr-i H H CN HR4 R3 R2 R1 R5CH2SMe H H CN HCH2SEt H H CN HCH2SPr-n H H CN HCH2SPr-i H H CN HCH2SO2Me H H CN HCH2SO2Et H H CN HCH2SO2Pr-n H H CN HCH2SO2Pr-i H H CN HCH2COMe H H CN HCH2COEt H H CN HCH2COPr-n H H CN HCH2COPr-i H H CN HCH2CO2H H H CN HCH2CO2Me H H CN HCH2CO2Et H H CN HCH2CO2Pr-n H H CN HCH2CO2Pr-i H H CN HCH2OCH2CH＝CH2 H H CN HCH2OCH2C≡CH H H CN HCH＝CHCO2Me H H CN HCH＝CHCO2Et H H CN HCH＝CHCO2Pr-n H H CN HCH＝CHCO2Pr-i H H CN HCH＝CHCN H H CN HPh H H CN HCH2Ph H H CN HOPh H H CN HSPh H H CN HSO2Ph H H CN HCONHMe H H CN HCONHEt H H CN HCONHPr-n H H CN HCONHPr-i H H CN HCONHBu-n H H CN HCONHBu-sec H H CN HCONHBu-t H H CN HCON(Me)2 H H CN HCON(Et)2 H H CN HCON(Pr-n)2 H H CN HH H Cl Cl HR1 R2 R3 R4 R5Cl H Cl H HCl H H Cl HH Cl Cl H HH Cl H Cl HH H Cl Cl HMe Cl H H HMe H Cl H HH Cl H Me HH H Cl Me HEt Cl H H HEt H Cl H HH Cl H Et HH H Cl Et HBr Br H H HBr H Br H HBr H H Br HH Br Br H HH Br H Br HH H Br Br HR1 R2 R3H H HMe H HH Me HEt H HH Et HPr-n H HH Pr-n HPr-i H HH Pr-i HBu-n H HH Bu-n HMe Me HMe Et HMe Pr-n HMe Pr-i HEt Me HEt Et HEt Pr-n HEt Pr-i HPr-n Me HPr-n Et HPr-n Pr-n HPr-n Pr-i HPr-i Me HPr-i Et HPr-i Pr-n HPr-i Pr-i HH Me MeH Me EtH Me Pr-nR1 R2 R3H Me Pr-iH Et EtH Et Pr-nMe Me MeEt Me MePr-n Me MePr-i Me MeH Cl HH Br HH I HH CF3 HH NO2 HH OMe HH SMe HH SO2Me HH COMe HH CO2H HH CO2Me HH CO2Et HH CH2Cl HH CH2Br HH CH2I HH CH2CF3 HH CH2CN HH CH2OH HH CH2OMe HH CH2OEt HH CH2SMe HH CH2SEt HH CH2SO2Me HH CH2SO2Et HH CH2COMe HH CH2COEt HH CH2CO2H HH CH2CO2Me HH CH2CO2Et HH CH2OCH2CH＝OH2 HH CH2OCH2C≡CH HH CH＝CHCO2Me HH CH＝CHCO2Et HR1 R2 R3H CH＝CHCN HH Ph HH Ph-2-Cl HH Ph-3-Cl HH Ph-4-Cl HH CH2Ph HH CH2Ph-2-Cl HH CH2Ph-3-Cl HH CH2Ph-4-Cl HMe Cl HMe Br HMe I HMe CF3 HMe NO2 HMe OMe HMe SMe HMe SO2Me HMe COMe HMe CO2H HMe CO2Me HMe CO2Et HMe CH2Cl HMe CH2Br HMe CH2I HMe CH2CF3 HMe CH2CN HMe CH2OH HMe CH2OMe HMe CH2OEt HMe CH2SMe HMe CH2SEt HMe CH2SO2Me HMe CH2SO2Et HMe CH2COMe HMe CH2COEt HMe CH2CO2H HMe CH2CO2Me HMe CH2CO2Et HMe CH2OCH2CH＝CH2 HMe CH2OCH2C≡CH HR1 R2 R3Me CH＝CHCO2Me HMe CH＝CHCO2Et HMe CH＝CHCN HMe Ph HMe Ph-2-Cl HMe Ph-3-Cl HMe Ph-4-Cl HMe CH2Ph HMe CH2Ph-2-Cl HMe CH2Ph-3-Cl HMe CH2Ph-4-Cl HEt Cl HEt Br HEt I HEt CF3 HEt NO2 HEt OMe HEt SMe HEt SO2Me HEt COMe HEt CO2H HEt CO2Me HEt CO2Et HEt CH2Cl HEt CH2Br HEt CH2I HEt CH2CF3 HEt CH2CN HEt CH2OH HEt CH2OMe HEt CH2OEt HEt CH2SMe HEt CH2SEt HEt CH2SO2Me HEt CH2SO2Et HEt CH2COMe HEt CH2COEt HEt CH2CO2H HEt CH2CO2Me HEt CH2CO2Et HR1 R2 R3Et CH2OCH2CH＝CH2 HEt CH2OCH2C≡CH HEt CH＝CHCO2Me HEt CH＝CHCO2Et HEt CH＝CHCN HEt Ph HEt Ph-2-Cl HEt Ph-3-Cl HEt Ph-4-Cl HEt CH2Ph HEt CH2Ph-2-Cl HEt CH2Ph-3-Cl HEt CH2Ph-4-Cl HCl Me HBr Me HI Me HCF3 Me HNO2 Me HOMe Me HSMe Me HSO2Me Me HCOMe Me HCO2H Me HCO2Me Me HCO2Et Me HCH2Cl Me HCH2Br Me HCH2I Me HCH2CF3 Me HCH2CN Me HCH2OH Me HCH2OMe Me HCH2OEt Me HCH2SMe Me HCH2SEt Me HCH2SO2Me Me HCH2SO2Et Me HCH2COMe Me HCH2COEt Me HCH2CO2H Me HR1 R2 R3CH2CO2Me Me HCH2CO2Et Me HCH2OCH2CH＝CH2 Me HCH2OCH2C≡CH Me HCH＝CHCO2Me Me HCH＝CHCO2Et Me HCH＝CHCN Me HPh Me HPh-2-Cl Me HPh-3-Cl Me HPh-4-Cl Me HCH2Ph Me HCH2Ph-2-Cl Me HCH2Ph-3-Cl Me HCH2Ph-4-Cl Me HCl Et HBr Et HI Et HCF3 Et HNO2 Et HOMe Et HSMe Et HSO2Me Et HCOMe Et HCO2H Et HCO2Me Et HCO2Et Et HCH2Cl Et HCH2Br Et HCH2I Et HCH2CF3 Et HCH2CN Et HCH2OH Et HCH2OMe Et HCH2OEt Et HCH2SMe Et HCH2SEt Et HCH2SO2Me Et HCH2SO2Et Et HCH2COMe Et HR1 R2 R3CH2COEt Et HCH2CO2H Et HCH2CO2Me Et HCH2CO2Et Et HCH2OCH2CH＝CH2 Et HCH2OCH2C≡CH Et HCH＝CHCO2Me Et HCH＝CHCO2Et Et HCH＝CHCN Et HPh Et HPh-2-Cl Et HPh-3-Cl Et HPh-4-Cl Et HCH2Ph Et HCH2Ph-2-Cl Et HCH2Ph-3-Cl Et HCH2Ph-4-Cl Et HR1 R2 R3H H HMe H HH Me HEt H HH Et HPr-n H HR1 R2 R3H Pr-n HMe Me HMe Et HMe Pr-n HMe Pr-i HEt Me HEt Et HEt Pr-n HEt Pr-i HPr-n Me HPr-n Et HPr-n Pr-n HPr-n Pr-i HPr-i Me HPr-i Et HPr-i Pr-n HPr-i Pr-i HH Me MeH Me EtH Me Pr-nH Me Pr-iH Et EtH Et Pr-nMe Me MeEt Me MePr-n Me MePr-i Me MeH Ph HH CH2Ph HMe Ph HMe CH2Ph HEt Ph HEt CH2Ph HPh Me HCH2Ph Me HPh Et HCH2Ph Et H
R1 R2 R3 X M GnH H H O H GaH H H S H G3H H H O Me GbH H H O Et GbH Me H O H GbH Me H S H G3H Et H O H GbH Et H S H G3H Pr-n H O H GbH Pr-n H S H G3H Pr-i H O H GbH Pr-i H S H G3H Bu-n H O H GbH Bu-n H S H G3Me H H O H GbMe H H S H G3Et H H O H GbEt H H S H G3Pr-n H H O H GbPr-n H H S H G3Pr-i H H O H GbPr-i H H S H G3Bu-n H H O H GbBu-n H H S H G3H Me Me O H GaH Me Me S H G3H Me Et O H GbH Me Et S H G3H Me Pr-n O H GbH Me Pr-n S H G3R1 R2 R3 X M GnH Me Pr-i O H GbH Me Pr-i S H G3H Me Bu-n O H GbH Me Bu-n S H G3H Et Et O H GbH Et Et S H G3H Et Pr-n O H GbH Et Pr-n S H G3H Et Pr-i O H GbH Et Pr-i S H G3H Pr-n Pr-n O H GbH Pr-n Pr-n S H G3Me Me H O H GbMe Me H S H G3Me Et H O H GbMe Et H S H G3Me Pr-n H O H GbMe Pr-n H S H G3Me Pr-i H O H GbMe Pr-i H S H G3Me Bu-n H O H GbMe Bu-n H S H G3Et Me H O H GbEt Me H S H G3Et Et H O H GbEt Et H S H G3Et Pr-n H O H GbEt Pr-n H S H G3Et Pr-i H O H GbEt Pr-i H S H G3Et Bu-n H O H GbEt Bu-n H S H G3Pr-n Me H O H GbPr-n Me H S H G3R1 R2 R3 X M GnPr-n Et H O H GbPr-n Et H S H G3Pr-n Pr-n H O H GbPr-n Pr-n H S H G3Pr-n Pr-i H O H GbPr-n Pr-i H S H G3Pr-n Bu-n H O H GbPr-n Bu-n H S H G3Pr-i Me H O H GbPr-i Me H S H G3Pr-i Et H O H GbPr-i Et H S H G3Pr-i Pr-n H O H GbPr-i Pr-n H S H G3Pr-i Pr-i H O H GbPr-i Pr-i H S H G3Pr-i Bu-n H O H GbPr-i Bu-n H S H G3Bu-n Me H O H GbBu-n Me H S H G3Bu-n Et H O H GbBu-n Et H S H G3Bu-n Pr-n H O H GbBu-n Pr-n H S H G3Bu-n Pr-i H O H GbBu-n Pr-i H S H G3Bu-n Bu-n H O H GbBu-n Bu-n H S H G3Me Me Me O H GbMe Me Me S H G3Me Me Et O H GbMe Me Et S H G3Me Me Pr-n O H GbMe Me Pr-n S H G3Me Me Pr-i O H GbMe Me Pr-i S H G3R1 R2 R3 X M GnMe Et Et O H GbMe Et Et S H G3Me Et Pr-n O H GbMe Et Pr-n S H G3Me Et Pr-i O H GbMe Et Pr-i S H G3Et Me Me O H GbEt Me Me S H G3Et Me Et O H GbEt Me Et S H G3Et Me Pr-n O H GbEt Me Pr-n S H G3Et Me Pr-i O H GbEt Me Pr-i S H G3Et Et Et O H GbEt Et Et S H G3Et Et Pr-n O H GbEt Et Pr-n S H G3Et Et Pr-i O H GbEt Et Pr-i S H G3Pr-n Me Me O H GbPr-n Me Me S H G3Pr-n Me Et O H GbPr-n Me Et S H G3Pr-n Me Pr-n O H GbPr-n Me Pr-n S H G3Pr-n Me Pr-i O H GbPr-n Me Pr-i S H G3Pr-n Et Et O H GbPr-n Et Et S H G3Pr-n Et Pr-n O H GbPr-n Et Pr-n S H G3Pr-n Et Pr-i O H GbPr-n Et Pr-i S H G3R1 R2 R3 X M GnPr-i Me Me O H GbPr-i Me Me S H G3Pr-i Me Et O H GbPr-i Me Et S H G3Pr-i Me Pr-n O H GbPr-i Me Pr-n S H G3Pr-i Me Pr-i O H GbPr-i Me Pr-i S H G3Pr-i Et E O H GbPr-i Et Et S H G3Pr-i Et Pr-n O H GbPr-i Et Pr-n S H G3Pr-i Et Pr-i O H GbPr-i Et Pr-i S H G3H Ph H O H GaH Ph H S H G3H Ph-2-Cl H O H GaH Ph-2-Cl H S H G3H Ph-3-Cl H O H GbH Ph-4-Cl H O H GbH CH2Ph H O H GaH CH2Ph H S H G3Ph H H O H GaPh H H S H G3Ph-2-Cl H H O H GaPh-2-Cl H H S H G3Ph-3-Cl H H O H GbPh-4-Cl H H O H GbCH2Ph H H O H GaCH2Ph H H S H G3Me Ph H O H GaMe Ph H S H G3Me Ph-2-Cl H O H GaMe Ph-2-Cl H S H G3Me Ph-3-Cl H O H GbMe Ph-4-Cl H O H GbMe CH2Ph H O H GaMe CH2Ph H S H G3R1 R2 R3 X M GnEt Ph H O H GaEt Ph H S H G3Et Ph-2-Cl H O H GaEt Ph-2-Cl H S H G3Et Ph-3-Cl H O H GbEt Ph-4-Cl H O H GbEt CH2Ph H O H GaEt CH2Ph H S H G3Pr-n Ph H O H GaPr-n Ph H S H G3Pr-n Ph-2-Cl H O H GaPr-n Ph-2-Cl H S H G3Pr-n Ph-3-Cl H O H GbPr-n Ph-4-Cl H O H GbPr-n CH2Ph H O H GaPr-n CH2Ph H S H G3Ph Me H O H GaPh Me H S H G3Ph-2-Cl Me H O H GaPh-2-Cl Me H S H G3Ph-3-Cl Me H O H GbPh-4-Cl Me H O H GbCH2Ph Me H O H GaCH2Ph Me H S H G3Ph Et H O H GaPh Et H S H G3Ph-2-Cl Et H O H GaPh-2-Cl Et H S H G3Ph-3-Cl Et H O H GbPh-4-Cl Et H O H GbCH2Ph Et H O H GaCH2Ph Et H S H G3Ph Pr-n H O H GaPh Pr-n H S H G3Ph-2-Cl Pr-n H O H GaPh-2-Cl Pr-n H S H G3Ph-3-Cl Pr-n H O H GbPh-4-Cl Pr-n H O H GbCH2Ph Pr-n H O H GaCH2Ph Pr-n H S H G3
表7R1 R2 R3 R4 X M GnH H H H O H GaH H H H S H G3H H H H O Me GbH H H H O Et GbH H H H O CH2CH＝CH2 GbH H H H O CH2C≡CH GbMe H H H O H GaMe H H H S H G3H Me H H O H GbH Me H H S H G3H H Me H O H GaH H Me H S H G3H H Me H O Me GbH H Me H O Et GbH H Me H O CH2CH＝CH2 GbH H Me H O CH2C≡ CH GbEt H H H O H GaEt H H H S H G3H Et H H O H GaH Et H H S H G3H H Et H O H GaH H Et H S H G3H H Et H O Me GbH H Et H O Et GbH H Et H O CH2CH＝CH2 GbH H Et H O CH2C≡CH GbPr-n H H H O H GbPr-n H H H S H G3H Pr-n H H O H GbH Pr-n H H S H G3R1 R2 R3 R4 X M GnH H Pr-n H O H GbH H Pr-n H S H G3Pr-i H H H O H GbPr-i H H H S H G3H Pr-i H H O H GbH Pr-i H H S H G3H H Pr-i H O H GbH H Pr-i H S H G3Bu-n H H H O H GbH Bu-n H H O H GbH H Bu-n H O H GbH H Me Me O H GaH H Me Me S H G3H H Me Me O Me GbH H Me Me O Et GbH H Me Me O CH2CH＝CH2 GbH H Me Me O CH2C≡CH GbMe H Me Me O H GaMe H Me Me S H G3H Me Me Me O H GaH Me Me Me S H G3Et H Me Me O H GbH Et Me Me O H GbPr-n H Me Me O H GbH Pr-n Me Me O H GbPr-i H Me Me O H GbH Pr-i Me Me O H GbBu-n H Me Me O H GbH Bu-n Me Me O H GbMe Me Me Me O H GaMe Me Me Me S H G3Me Et Me Me O H GbMe Pr-n Me Me O H GbMe Bu-n Me Me O H GbEt Me Me Me O H GbEt Et Me Me O H GbEt Pr-n Me Me O H GbEt Bu-n Me Me O H GbPr-n Me Me Me O H GbPr-n Et Me Me O H GbR1 R2 R3 R4 X M GnPr-n Pr-n Me Me O H GbPr-n Bu-n Me Me O H GbBu-n Me Me Me O H GbBu-n Et Me Me O H GbBu-n Pr-n Me Me O H GbBu-n Bu-n Me Me O H GbF H Me Me O H GaCl H Me Me O H GaBr H Me Me O H GaI H Me Me O H GaCH＝CH2 H Me Me O H GaCH2CH＝CH2 H Me Me O H GaC≡CH H Me Me O H GaCH2C≡CH H Me Me O H GaCH2F H Me Me O H GaCHF2 H Me Me O H GaCN H Me Me O H GaNH2 H Me Me O H GaNHCOMe H Me Me O H GaCH2NH2 H Me Me O H GaCH2NHCOMe H Me Me O H GaCH2OCHF2 H Me Me O H GaCF2 H Me Me O H GaNO2 H Me Me O H GbOMe H Me Me O H GaOEt H Me Me O H GaOPr-n H Me Me O H GbSMe H Me Me O H GaSEt H Me Me O H GaSO2Me H Me Me O H GaSO2Et H Me Me O H GaCOMe H Me Me O H GaCOEt H Me Me O H GaCO2H H Me Me O H GbCO2Me H Me Me O H GaCO2Et H Me Me O H GaCO2Pr-n H Me Me O H GbCO2Bu-n H Me Me O H GcCH2Cl H Me Me O H GaCH2Br H Me Me O H GbR1 R2 R3 R4 X M GnCH2I H Me Me O H GbCH2CF3 H Me Me O H GaCH2CN H Me Me O H GaCH2OH H Me Me O H GbCH2OMe H Me Me O H GaCH2OEt H Me Me O H GaCH2OPr-n H Me Me O H GbCH2SMe H Me Me O H GaCH2SEt H Me Me O H GaCH2SPr-n H Me Me O H GbCH2SO2Me H Me Me O H GaCH2SO2Et H Me Me O H GaCH2COMe H Me Me O H GaCH2COEt H Me Me O H GaCH2COPr-n H Me Me O H GbCH2CO2H H Me Me O H GbCH2CO2Me H Me Me O H GaCH2CO2Et H Me Me O H GaCH2CO2Pr-n H Me Me O H GbCH2OCH2CH＝CH2 H Me Me O H GbCH2OCH2C≡CH H Me Me O H GbCH＝CHCO2Me H Me Me O H GaCH＝CHCO2Et H Me Me O H GaCH＝CHCO2Pr-n H Me Me O H GbCH＝CHCN H Me Me O H GaPh H Me Me O H GaCH2Ph H Me Me O H GaOPh H Me Me O H GaSPh H Me Me O H GaSO2Ph H Me Me O H GaCONHMe H Me Me O H GaCONHEt H Me Me O H GaCON(Me)2 H Me Me O H GaCON(Et)2 H Me Me O H GaF Me Me Me O H GaCl Me Me Me O H GaBr Me Me Me O H GaI Me Me Me O H GaCH＝CH2 Me Me Me O H GaCH2CH＝CH2 Me Me Me O H GaR1 R2 R3 R4 X M GnC≡CH Me Me Me O H GaCH2C≡CH Me Me Me O H GaCH2F Me Me Me O H GaCHF2 Me Me Me O H GaCN Me Me Me O H GaNH2 Me Me Me O H GaNHCOMe Me Me Me O H GaCH2NH2 Me Me Me O H GaCH2NHCOMe Me Me Me O H GaCH2OCHF2 Me Me Me O H GaCF3 Me Me Me O H GaNO2 Me Me Me O H GbOMe Me Me Me O H GaOEt Me Me Me O H GaOPr-n Me Me Me O H GbSMe Me Me Me O H GaSEt Me Me Me O H GaSO2Me Me Me Me O H GaSO2Et Me Me Me O H GaCOMe Me Me Me O H GaCOEt Me Me Me O H GaCO2H Me Me Me O H GbCO2Me Me Me Me O H GaCO2Et Me Me Me O H GaCO2Pr-n Me Me Me O H GbCO2Bu-n Me Me Me O H GcCH2Cl Me Me Me O H GaCH2Br Me Me Me O H GbCH2I Me Me Me O H GbCH2CF3 Me Me Me O H GaCH2CN Me Me Me O H GaCH2OH Me Me Me O H GbCH2OMe Me Me Me O H GaCH2OEt Me Me Me O H GaCH2OPr-n Me Me Me O H GbCH2SMe Me Me Me O H GaCH2SEt Me Me Me O H GaCH2SPr-n Me Me Me O H GbCH2SO2Me Me Me Me O H GaCH2SO2Et Me Me Me O H GaR1 R2 R3 R4 X M GnCH2COMe Me Me Me O H GaCH2COEt Me Me Me O H GaCH2COPr-n Me Me Me O H GbCH2CO2H Me Me Me O H GbCH2CO2Me Me Me Me O H GaCH2CO2Et Me Me Me O H GaCH2CO2Pr-n Me Me Me O H GbCH2OCH2CH＝CH2 Me Me Me O H GbCH2OCH2C≡CH Me Me Me O H GbCH＝CHCO2Me Me Me Me O H GaCH＝CHCO2Et Me Me Me O H GaCH＝CHCO2Pr-n Me Me Me O H GbCH＝CHCN Me Me Me O H GaPh Me Me Me O H GaCH2Ph Me Me Me O H GaOPh Me Me Me O H GaSPh Me Me Me O H GaSO2Ph Me Me Me O H GaCONHMe Me Me Me O H GaCONHEt Me Me Me O H GaCON(Me)2 Me Me Me O H GaCON(Et)2 Me Me Me O H GaF Cl Me Me O H GaCl Cl Me Me O H GaBr Cl Me Me O H GaI Cl Me Me O H GaCH＝CH2 Cl Me Me O H GaCH2CH＝CH2 Cl Me Me O H GaC≡CH Cl Me Me O H GaCH2C≡CM Cl Me Me O H GaCH2F Cl Me Me O H GaCHF2 Cl Me Me O H GaCN Cl Me Me O H GaNH2 Cl Me Me O H GaNHCOMe Cl Me Me O H GaCH2NH2 Cl Me Me O H GaCH2NHCOMe Cl Me Me O H GaCH2OCHF2 Cl Me Me O H GaCF3 Cl Me Me O H GaNO2 Cl Me Me O H GbR1 R2 R3 R4 X M GnOMe Cl Me Me O H GaOEt Cl Me Me O H GaOPr-n Cl Me Me O H GbSMe Cl Me Me O H GaSEt Cl Me Me O H GaSO2Me Cl Me Me O H GaSO2Et Cl Me Me O H GaCOMe Cl Me Me O H GaCOEt Cl Me Me O H GaCO2H Cl Me Me O H GbCO2Me Cl Me Me O H GaCO2Et Cl Me Me O H GaCO2Pr-n Cl Me Me O H GbCO2Bu-n Cl Me Me O H GcCH2Cl Cl Me Me O H GaCH2Br Cl Me Me O H GbCH2I Cl Me Me O H GbCH2CF3 Cl Me Me O H GaCH2CN Cl Me Me O H GaCH2OH Cl Me Me O H GbCH2OMe Cl Me Me O H GaCH2OEt Cl Me Me O H GaCH2OPr-n Cl Me Me O H GbCH2SMe Cl Me Me O H GaCH2SEt Cl Me Me O H GaCH2SPr-n Cl Me Me O H GbCH2SO2Me Cl Me Me O H GaCH2SO2Et Cl Me Me O H GaCH2COMe Cl Me Me O H GaCH2COEt Cl Me Me O H GaCH2COPr-n Cl Me Me O H GbCH2CO2H Cl Me Me O H GbCH2CO2Me Cl Me Me O H GaCH2CO2Et Cl Me Me O H GaCH2CO2Pr-n Cl Me Me O H GbCH2OCH2CH＝CH2 Cl Me Me O H GbCH2OCH2C≡CH Cl Me Me O H GbCH＝CHCO2Me Cl Me Me O H GaCH＝CHCO2Et Cl Me Me O H GaCH＝CHCO2Pr-n Cl Me Me O H GbR1 R2 R3 R4 X M GnCH＝CHCN Cl Me Me O H GaPh Cl Me Me O H GaCH2Ph Cl Me Me O H GaOPh Cl Me Me O H GaSPh Cl Me Me O H GaSO2Ph Cl Me Me O H GaCONHMe Cl Me Me O H GaCONHEt Cl Me Me O H GaCON(Me)2 Cl Me Me O H GaCON(Et)2 Cl Me Me O H GaH H Me Et O H GaF H Me Et O H GaCl H Me Et O H GaBr H Me Et O H GaI H Me Et O H GaCH＝CH2 H Me Et O H GaCH2CH＝CH2 H Me Et O H GaC≡CH H Me Et O H GaCH2C≡CH H Me Et O H GaCH2F H Me Et O H GaCHF2 H Me Et O H GaCN H Me Et O H GaNH2 H Me Et O H GaNHCOMe H Me Et O H GaCH2NH2 H Me Et O H GaCH2NHCOMe H Me Et O H GaCH2OCHF2 H Me Et O H GaCF3 H Me Et O H GaNO2 H Me Et O H GbOMe H Me Et O H GaOEt H Me Et O H GaOPr-n H Me Et O H GbSMe H Me Et O H GaSEt H Me Et O H GaSO2Me H Me Et O H GaSO2Et H Me Et O H GaCOMe H Me Et O H GaCOEt H Me Et O H GaCO2H H Me Et O H GbCO2Me H Me Et O H GaR1 R2 R3 R4 X M GnCO2Et H Me Et O H GaCO2Pr-n H Me Et O H GbCO2Bu-n H Me Et O H GcCH2Cl H Me Et O H GaCH2Br H Me Et O H GbCH2I H Me Et O H GbCH2CF3 H Me Et O H GaCH2CN H Me Et O H GaCH2OH H Me Et O H GbCH2OMe H Me Et O H GaCH2OEt H Me Et O H GaCH2OPr-n H Me Et O H GbCH2SMe H Me Et O H GaCH2SEt H Me Et O H GaCH2SPr-n H Me Et O H GbCH2SO2Me H Me Et O H GaCH2SO2Et H Me Et O H GaCH2COMe H Me Et O H GaCH2COEt H Me Et O H GaCH2COPr-n H Me Et O H GbCH2CO2H H Me Et O H GbCH2CO2Me H Me Et O H GaCH2CO2Et H Me Et O H GaCH2CO2Pr-n H Me Et O H GbCH2OCH2CH＝CH2 H Me Et O H GbCH2OCH2C≡CH H Me Et O H GbCH＝CHCO2Me H Me Et O H GaCH＝CHCO2Et H Me Et O H GaCH＝CHCO2Pr-n H Me Et O H GbCH＝CHCN H Me Et O H GaPh H Me Et O H GaCH2Ph H Me Et O H GaOPh H Me Et O H GaSPh H Me Et O H GaSO2Ph H Me Et O H GaCONHMe H Me Et O H GaCONHEt H Me Et O H GaCON(Me)2 H Me Et O H GaCON(Et)2 H Me Et O H GaH H Me Pr-n O H GaR1 R2 R3 R4 X M GnF H Me Pr-n O H GaCl H Me Pr-n O H GaBr H Me Pr-n O H GaI H Me Pr-n O H GaCH＝CH2 H Me Pr-n O H GaCH2CH＝CH2 H Me Pr-n O H GaC≡CH H Me Pr-n O H GaCH2C≡CH H Me Pr-n O H GaCH2F H Me Pr-n O H GaCHF2 H Me Pr-n O H GaCN H Me Pr-n O H GaNH2 H Me Pr-n O H GaNHCOMe H Me Pr-n O H GaCH2NH2 H Me Pr-n O H GaCH2NHCOMe H Me Pr-n O H GaCH2OCHF2 H Me Pr-n O H GaCF3 H Me Pr-n O H GaNO2 H Me Pr-n O H GbOMe H Me Pr-n O H GaOEt H Me Pr-n O H GaOPr-n H Me Pr-n O H GbSMe H Me Pr-n O H GaSEt H Me Pr-n O H GaSO2Me H Me Pr-n O H GaSO2Et H Me Pr-n O H GaCOMe H Me Pr-n O H GaCOEt H Me Pr-n O H GaCO2H H Me Pr-n O H GbCO2Me H Me Pr-n O H GaCO2Et H Me Pr-n O H GaCO2Pr-n H Me Pr-n O H GbCO2Bu-n H Me Pr-n O H GcCH2Cl H Me Pr-n O H GaCH2Br H Me Pr-n O H GbCH2I H Me Pr-n O H GbCH2CF3 H Me Pr-n O H GaCH2CN H Me Pr-n O H GaCH2OH H Me Pr-n O H GbCH2OMe H Me Pr-n O H GaCH2OEt H Me Pr-n O H GaR1 R2 R3 R4 X M GnCH2OPr-n H Me Pr-n O H GbCH2SMe H Me Pr-n O H GaCH2SEt H Me Pr-n O H GaCH2SPr-n H Me Pr-n O H GbCH2SO2Me H Me Pr-n O H GaCH2SO2Et H Me Pr-n O H GaCH2COMe H Me Pr-n O H GaCH2COEt H Me Pr-n O H GaCH2COPr-n H Me Pr-n O H GbCH2CO2H H Me Pr-n O H GbCH2CO2Me H Me Pr-n O H GaCH2CO2Et H Me Pr-n O H GaCH2CO2Pr-n H Me Pr-n O H GbCH2OCH2CH＝CH2 H Me Pr-n O H GbCH2OCH2C≡CH H Me Pr-n O H GbCH＝CHCO2Me H Me Pr-n O H GaCH＝CHCO2Et H Me Pr-n O H GaCH＝CHCO2Pr-n H Me Pr-n O H GbCH＝CHCN H Me Pr-n O H GaPh H Me Pr-n O H GaCH2Ph H Me Pr-n O H GaOPh H Me Pr-n O H GaSPh H Me Pr-n O H GaSO2Ph H Me Pr-n O H GaCONHMe H Me Pr-n O H GaCONHEt H Me Pr-n O H GaCON(Me)2 H Me Pr-n O H GaCON(Et)2 H Me Pr-n O H GaH H Me Pr-i O H GaF H Me Pr-i O H GaCl H Me Pr-i O H GaBr H Me Pr-i O H GaI H Me Pr-i O H GaCH＝CH2 H Me Pr-i O H GaCH2CH＝CH2 H Me Pr-i O H GaC≡CH H Me Pr-i O H GaCH2C≡CH H Me Pr-i O H GaCH2F H Me Pr-i O H GaCHP2 H Me Pr-i O H GaCN H Me Pr-i O H GaR1 R2 R3 R4 X M GnNH2 H Me Pr-i O H GaNHCOMe H Me Pr-i O H GaCH2NH2 H Me Pr-i O H GaCH2NHCOMe H Me Pr-i O H GaCH2OCHF2 H Me Pr-i O H GaCF3 H Me Pr-i O H GaNO2 H Me Pr-i O H GbOMe H Me Pr-i O H GaOEt H Me Pr-i O H GaOPr-n H Me Pr-i O H GbSMe H Me Pr-i O H GaSEt H Me Pr-i O H GaSO2Me H Me Pr-i O H GaSO2Et H Me Pr-i O H GaCOMe H Me Pr-i O H GaCOEt H Me Pr-i O H GaCO2H H Me Pr-i O H GbCO2Me H Me Pr-i O H GaCO2Et H Me Pr-i O H GaCO2Pr-n H Me Pr-i O H GbCO2Bu-n H Me Pr-i O H GcCH2Cl H Me Pr-i O H GaCH2Br H Me Pr-i O H GbCH2I H Me Pr-i O H GbCH2CF3 H Me Pr-i O H GaCH2CN H Me Pr-i O H GaCH2OH H Me Pr-i O H GbCH2OMe H Me Pr-i O H GaCH2OEt H Me Pr-i O H GaCH2OPr-n H Me Pr-i O H GbCH2SMe H Me Pr-i O H GaCH2SEt H Me Pr-i O H GaCH2SPr-n H Me Pr-i O H GbCH2SO2Me H Me Pr-i O H GaCH2SO2Et H Me Pr-i O H GaCH2COMe H Me Pr-i O H GaCH2COEt H Me Pr-i O H GaCH2COPr-n H Me Pr-i O H GbCH2CO2H H Me Pr-i O H GbCH2CO2Me H Me Pr-i O H GaR1 R2 R3 R4 X M GnCH2CO2Et H Me Pr-i O H GaCH2CO2Pr-n H Me Pr-i O H GbCH2OCH2CH＝CH2 H Me Pr-i O H GbCH2OCH2C≡CH H Me Pr-i O H GbCH＝CHCO2Me H Me Pr-i O H GaCH＝CHCO2Et H Me Pr-i O H GaCH＝CHCO2Pr-n H Me Pr-i O H GbCH＝CHCN H Me Pr-i O H GaPh H Me Pr-i O H GaCH2Ph H Me Pr-i O H GaOPh H Me Pr-i O H GaSPh H Me Pr-i O H GaSO2Ph H Me Pr-i O H GaCONHMe H Me Pr-i O H GaCONHEt H Me Pr-i O H GaCON(Me)2 H Me Pr-i O H GaCON(Et)2 H Me Pr-i O H GaH H Et Et O H GaF H Et Et O H GaCl H Et Et O H GaBr H Et Et O H GaI H Et Et O H GaCH＝CH2 H Et Et O H GaCH2CH＝CH2 H Et Et O H GaC≡CH H Et Et O H GaCH2C≡CH H Et Et O H GaCH2F H Et Et O H GaCHF2 H Et Et O H GaCN2 H Et Et O H GaNH2 H Et Et O H GaNHCOMe H Et Et O H GaCH2NH2 H Et Et O H GaCH2NHCOMe H Et Et O H GaCH2OCHF2 H Et Et O H GaCF3 H Et Et O H GaNO2 H Et Et O H GbOMe H Et Et O H GaOEt H Et Et O H GaOPr-n H Et Et O H GbSMe H Et Et O H GaR1 R2 R3 R4 X M GnSEt H Et Et O H GaSO2Me H Et Et O H GaSO2Et H Et Et O H GaCOMe H Et Et O H GaCOEt H Et Et O H GaCO2H H Et Et O H GbCO2Me H Et Et O H GaCO2Et H Et Et O H GaCO2Pr-n H Et Et O H GbCO2Bu-n H Et Et O H GcCH2Cl H Et Et O H GaCH2Br H Et Et O H GbCH2I H Et Et O H GbCH2CF3 H Et Et O H GaCH2CN H Et Et O H GaCH2OH H Et Et O H GbCH2OMe H Et Et O H GaCH2OEt H Et Et O H GaCH2OPr-n H Et Et O H GbCH2SMe H Et Et O H GaCH2SEt H Et Et O H GaCH2SPr-n H Et Et O H GbCH2SO2Me H Et Et O H GaCH2SO2Et H Et Et O H GaCH2COMe H Et Et O H GaCH2COEt H Et Et O H GaCH2COPr-n H Et Et O H GbCH2CO2H H Et Et O H GbCH2CO2Me H Et Et O H GaCH2CO2Et H Et Et O H GaCH2CO2Pr-n H Et Et O H GbCH2OCH2CH＝CH2 H Et Et O H GbCH2OCH2C≡CH H Et Et O H GbCH＝CHCO2Me H Et Et O H GaCH＝CHCO2Et H Et Et O H GaCH＝CHCO2Pr-n H Et Et O H GbCH＝CHCN H Et Et O H GaPh H Et Et O H GaCH2Ph H Et Et O H GaOPh H Et Et O H GaR1 R2 R3 R4 X M GnSPh H Et Et O H GaSO2Ph H Et Et O H GaCONHMe H Et Et O H GaCONHEt H Et Et O H GaCON(Me)2 H Et Et O H GaCON(Et)2 H Et Et O H GaH H F Me O H GaH H Cl Me O H GaH H Br Me O H GaH H I Me O H GaH H CH＝CH2 Me O H GaH H CH2CH＝CH2 Me O H GaH H C≡CH Me O H GaH H CH2C≡CH Me O H GaH H CH2F Me O H GaH H CHF2 Me O H GaH H CN Me O H GaH H NH2 Me O H GaH H NHCOMe Me O H GaH H CH2NH2 Me O H GaH H CH2NHCOMe Me O H GaH H CH2OCHF2 Me O H GaH H CF3 Me O H GaH H NO2 Me O H GbH H OMe Me O H GaH H OEt Me O H GaH H OPr-n Me O H GbH H SMe Me O H GaH H SEt Me O H GaH H SO2Me Me O H GaH H SO2Et Me O H GaH H COMe Me O H GaH H COEt Me O H GaH H CO2H Me O H GbH H CO2Me Me O H GaH H CO2Et Me O H GaH H CO2Pr-n Me O H GbH H CO2Bu-n Me O H GcH H CH2Cl Me O H GaH H CH2Br Me O H GbR1 R2 R3 R4 X M GnH H CH2I Me O H GbH H CH2CF3 Me O H GaH H CH2CN Me O H GaH H CH2OH Me O H GbH H CH2OMe Me O H GaH H CH2OEt Me O H GaH H CH2OPr-n Me O H GbH H CH2SMe Me O H GaH H CH2SEt Me O H GaH H CH2SPr-n Me O H GbH H CH2SO2Me Me O H GaH H CH2SO2Et Me O H GaH H CH2COMe Me O H GaH H CH2COEt Me O H GaH H CH2COPr-n Me O H GbH H OH2CO2H Me O H GbH H CH2CO2Me Me O H GaH H CH2CO2Et Me O H GaH H CH2CO2Pr-n Me O H GbH H CH2OCH2CH＝CH2 Me O H GbH H CH2OCH2C≡CH Me O H GbH H CH＝CHCO2Me Me O H GaH H CH＝CHCO2Et Me O H GaH H CH＝CHCO2Pr-n Me O H GbH H CH＝CHCN Me O H GaH H Ph Me O H GaH H CH2Ph Me O H GaH H OPh Me O H GaH H SPh Me O H GaH H SO2Ph Me O H GaH H CONHMe Me O H GaH H CONHEt Me O H GaH H CON(Me)2 Me O H GaH H CON(Et)2 Me O H GaMe H F Me O H GaMe H Cl Me O H GaMe H Br Me O H GaMe H I Me O H GaMe H CH＝CH2 Me O H GaMe H CH2CH＝CH2 Me O H GaR1 R2 R3 R4 X M GnMe H C≡CH Me O H GaMe H CH2C≡CH Me O H GaMe H CH2F Me O H GaMe H CHF2 Me O H GaMe H CN Me O H GaMe H NH2 Me O H GaMe H NHCOMe Me O H GaMe H CH2NH2 Me O H GaMe H CH2NHCOMe Me O H GaMe H CH2OCHF2 Me O H GaMe H CF3 Me O H GaMe H NO2 Me O H GbMe H OMe Me O H GaMe H OEt Me O H GaMe H OPr-n Me O H GbMe H SMe Me O H GaMe H SEt Me O H GaMe H SO2Me Me O H GaMe H SO2Et Me O H GaMe H COMe Me O H GaMe H COEt Me O H GaMe H CO2H Me O H GbMe H CO2Me Me O H GaMe H CO2Et Me O H GaMe H CO2Pr-n Me O H GbMe H CO2Bu-n Me O H GcMe H CH2Cl Me O H GaMe H CH2Br Me O H GbMe H CH2I Me O H GbMe H CH2CF3 Me O H GaMe H CH2CN Me O H GaMe H CH2OH Me O H GbMe H CH2OMe Me O H GaMe H CH2OEt Me O H GaMe H CH2OPr-n Me O H GbMe H CH2SMe Me O H GaMe H CH2SEt Me O H GaMe H CH2SPr-n Me O H GbMe H CH2SO2Me Me O H GaMe H CH2SO2Et Me O H GaR1 R2 R3 R4 X M GnMe H CH2COMe Me O H GaMe H CH2COEt Me O H GaMe H CH2COPr-n Me O H GbMe H CH2CO2H Me O H GbMe H CH2CO2Me Me O H GaMe H CH2CO2Et Me O H GaMe H CH2CO2Pr-n Me O H GbMe H CH2OCH2CH＝CH2 Me O H GbMe H CH2OCH2C≡CH Me O H GbMe H CH＝CHCO2Me Me O H GaMe H CH＝CHCO2Et Me O H GaMe H CH＝CHCO2Pr-n Me O H GbMe H CH＝CHCN Me O H GaMe H Ph Me O H GaMe H CH2Ph Me O H GaMe H OPh Me O H GaMe H SPh Me O H GaMe H SO2Ph Me O H GaMe H CONHMe Me O H GaMe H CONHEt Me O H GaMe H CON(Me)2 Me O H GaMe H CON(Et)2 Me O H GaMe F Me H O M GaMe Cl Me H O H GaMe Br Me H O H GaMe I Me H O H GaMe CH＝CH2 Me H O H GaMe CH2CH＝CH2 Me H O H GaMe C≡CH Me H O H GaMe CH2C≡CH Me H O H GaMe CH2F Me H O H GaMe CHF2 Me H O H GaMe CN Me H O H GaMe NH2 Me H O H GaMe NHCOMe Me H O H GaMe CH2NH2 Me H O H GaMe CH2NHCOMe Me H O H GaMe CH2OCHF2 Me H O H GaMe CF3 Me H O H GaMe MO2 Me H O H GbR1 R2 R3 R4 X M GnMe OMe Me H O H GaMe OEt Me H O H GaMe OPr-n Me H O H GbMe SMe Me H O H GaMe SEt Me H O H GaMe SO2Me Me H O H GaMe SO2Et Me H O H GaMe COMe Me H O H GaMe COEt Me H O H GaMe CO2H Me H O H GbMe CO2Me Me H O H GaMe CO2Et Me H O H GaMe CO2Pr-n Me H O H GbMe CO2Bu-n Me H O H GcMe CH2Cl Me H O H GaMe CH2Br Me H O H GbMe CH2I Me H O H GbMe CH2CF3 Me H O H GaMe CH2CN Me H O H GaMe CH2OH Me H O H GbMe CH2OMe Me H O H GaMe CH2OEt Me H O H GaMe CH2OPr-n Me H O H GbMe CH2SMe Me H O H GaMe CH2SEt Me H O H GaMe CH2SPr-n Me H O H GbMe CH2SO2Me Me H O H GaMe CH2SO2Et Me H O H GaMe CH2COMe Me H O H GaMe CH2COEt Me H O H GaMe CH2COPr-n Me H O H GbMe CH2CO2H Me H O H GbMe CH2CO2Me Me H O H GaMe CH2CO2Et Me H O H GaMe CH2CO2Pr-n Me H O H GbMe CH2OCH2CH＝CH2 Me H O H GbMe CH2OCH2C≡CH Me H O H GbMe CH＝CHCO2Me Me H O H GaMe CH＝CHCO2Et Me H O H GaMe CH＝CHCO2Pr-n Me H O H GbR1 R2 R3 R4 X M GnMe CH＝CHCN Me H O H GaMe Ph Me H O H GaMe CH2Ph Me H O H GaMe OPh Me H O H GaMe SPh Me H O H GaMe SO2Ph Me H O H GaMe CONHMe Me H O H GaMe CONHEt Me H O H GaMe CON(Me)2 Me H O H GaMe CON(Et)2 Me H O H GaR1 R2 R3 R4 X M GnH H F H O H GaH H F H S H G3H H Cl H O H GaH H Cl H S H G3H H Br H O H GaH H Br H S H G3H H I H O H GaH H I H S H G3H H CH＝CH2 H O H GaH H CH＝CH2 H S H G3H H CH2CH＝CH2 H O H GaH H CH2CH＝CH2 H S H G3H H C≡CH H O H GaH H C≡CH H S H G3H H CH2C≡CH H O H GaH H CH2C≡CH H S H G3H H CH2OSO2Me H O H GaH H CH2OSO2Me H S H G3H H CHF2 H O H GaH H CHF2 H S H G3H H CN H O H GaH H CN H S H G3H H NH2 H O H GaH H NH2 H S H G3H H NHCOMe H O H GaH H NHCOMe H S H G3H H CH2NH2 H O H GaH H CH2NH2 H S H G3H H CH2NHCOMe H O H GaH H CH2NHCOMe H S H G3H H CH2OCHF2 H O H GaH H CH2OCHF2 H S H G3H H CF3 H O H GaH H CF3 H S H G3H H CF3 H O Me GbH H CF3 H O Et GbH H CF3 H O CH2CH＝CH2 GbH H CF3 H O CH2C≡CH GbH H NO2 H O H GbH H NO2 H S H G3H H NO2 H O Me GbR1 R2 R3 R4 X M GnH H NO2 H O Et GbH H NO2 H O CH2CH＝CH2GbH H NO2 H O CH2C≡CH GbH H OMe H O H GaH H OMe H S H G3H H OMe H O Me GbH H OMe H O Et GbH H OMe H O CH2CH＝CH2GbH H OMe H O CH2C≡CH GbH H OEt H O H GaH H OEt H S H G3H H OEt H O Me GbH H OEt H O Et GbH H OEt H O CH2CH＝CH2GbH H OEt H O CH2C≡CH GbH H OPr-n H O H GbH H OPr-n H S H G3H H OBu-n H O H GcH H OPen-n H O H GcH H SMe H O H GaH H SMe H S H G3H H SMe H O Me GbH H SMe H O Et GbH H SMe H O CH2CH＝CH2GbH H SMe H O CH2C≡CH GbH H SEt H O H GaH H SEt H S H G3H H SEt H O Me GbH H SEt H O Et GbH H SEt H O CH2CH＝CH2GbH H SEt H O CH2C≡CH GbH H SPr-n H O H GbH H SPr-n H S H G3H H SBu-n H O H GcH H SPen-n H O H GcH H SO2Me H O H GaH H SO2Me H S H G3H H SO2Me H O Me GbH H SO2Me H O Et GbH H SO2Me H O CH2CH＝CH2GbR1 R2 R3 R4 X M GnH H SO2Me H O CH2C≡CH GbH H SO2Et H O H GaH H SO2Et H S H G3H H SO2Et H O Me GbH H SO2Et H O Et GbH H SO2Et H O CH2CH＝CH2GbH H SO2Et H O CH2C≡CH GbH H SO2Pr-n H O H GbH H SO2Pr-n H S H G3H H COMe H O H GaH H COMe H S H G3H H COMe H O Me GbH H COMe H O Et GbH H COMe H O CH2CH＝CH2GbH H COMe H O CH2C≡CH GbH H COEt H O H GaH H COEt H S H G3H H COEt H O Me GbH H COEt H O Et GbH H COEt H O CH2CH＝CH2GbH H COEt H O CH2C≡CH GbH H COPr-n H O H GbH H COPr-n H S H G3H H CO2H H O H GbH H CO2H H S H G3H H CO2Me H O H GaH H CO2Me H S H G3H H CO2Me H O Me GbH H CO2Me H O Et GbH H CO2Me H O CH2CH＝CH2GbH H CO2Me H O CH2C≡CH GbH H CO2Et H O H GaH H CO2Et H S H G3H H CO2Et H O Me GbH H CO2Et H O Et GbH H CO2Et H O CH2CH＝CH2GbH H CO2Et H O CH2C≡CH GbH H CO2Pr-n H O H GbH H CO2Pr-n H S H G3H H CO2Bu-n H O H GcR1 R2 R3 R4 X M GnH H CO2Pen-n H O H GcH H CH2F H O H GaH H CH2F H S H G3H H CH2F H O Me GbH H CH2F H O Et GbH H CH2F H O CH2CH＝CH2GbH H CH2F H O CH2C≡CH GbH H CH2Cl H O H GaH H CH2Cl H S H G3H H CH2Cl H O Me GbH H CH2Cl H O Et GbH H CH2Cl H O CH2CH＝CH2GbH H CH2Cl H O CH2C≡CH GbH H CH2Br H O H GbH H CH2Br H S H G3H H CH2I H O H GbH H CH2I H S H G3H H CH2CF3 H O H GaH H CH2CF3 H S H G3H H CH2CF3 H O Me GbH H CH2CF3 H O Et GbH H CH2CF3 H O CH2CH＝CH2GbH H CH2CF3 H O CH2C≡CH GbH H CH2CN H O H GaH H CH2CN H S H G3H H CH2CN H O Me GbH H CH2CN H O Et GbH H CH2CN H O CH2CH＝CH2GbH H CH2CN H O CH2C≡CH GbH H CH2OH H O H GbH H CH2OMe H O H GaH H CH2OMe H S H G3H H CH2OMe H O Me GbH H CH2OMe H O Et GbH H CH2OMe H O CH2CH＝CH2GbH H CH2OMe H O CH2C≡CH GbH H CH2OEt H O H GaH H CH2OEt H S H G3H H CH2OEt H O Me GbH H CH2OEt H O Et GbR1 R2 R3 R4 X M GnH H CH2OEt H O CH2CH＝CH2GbH H CH2OEt H O CH2C≡CH GbH H CH2OPr-n H O H GbH H CH2OPr-n H S H G3H H CH2SMe H O H GaH H CH2SMe H S H G3H H CH2SMe H O Me GbH H CH2SMe H O Et GbH H CH2SMe H O CH2CH＝CH2GbH H CH2SMe H O CH2C≡CH GbH H CH2SEt H O H GaH H CH2SEt H S H G3H H CH2SEt H O Me GbH H CH2SEt H O Et GbH H CH2SEt H O CH2CH＝CH2GbH H CH2SEt H O CH2C≡CH GbH H CH2SPr-n H O H GbH H CH2SPr-n H S H G3H H CH2SO2Me H O H GaH H CH2SO2Et H O H GaH H CH2SO2Me H S H G3H H CH2SO2Et H S H G3H H CH2COMe H O H GaH H CH2COMe H S H G3H H CH2COMe H O Me GbH H CH2COMe H O Et GbH H CH2COMe H O CH2CH＝CH2GbH H CH2COMe H O CH2C≡CH GbH H CH2COEt H O H GaH H CH2COEt H S H G3H H CH2COEt H O Me GbH H CH2COEt H O Et GbH H CH2COEt H O CH＝CH2 GbH H CH2COEt H O CH2C≡CH GbH H CH2COPr-n H O H GbH H CH2COPr-n H S H G3H H CH2CO2H H O H GbH H CH2CO2H H S H G3H H CH2CO2Me H O H GaH H CH2CO2Me H S H G3R1 R2 R3 R4 X M GnH H CH2CO2Me H O Me GbH H CH2CO2Me H O Et GbH H CH2CO2Me H O CH2CH＝CH2 GbH H CH2CO2Me H O CH2C≡CH GbH H CH2CO2Et H O H GaH H CH2CO2Et H S H G3H H CH2CO2Et H O Me GbH H CH2CO2Et H O Et GbH H CH2CO2Et H O CH2CH＝CH2 GbH H CH2CO2Et H O CH2C≡CH GbH H CH2CO2Pr-n H O H GbH H CH2CO2Pr-n H S H G3H H CH2OCH2CH＝CH2 H O H GbH H CH2OCH2CH＝CH2 H O Me GbH H CH2OCH2CH＝CH2 H O Et GbH H CH2OCH2OH＝CH2 H O CH2CH＝CH2 GbH H CH2OCH2CH＝CH2 H O CH2C≡CH GbH H CH2OCH2C≡CH H O H GbH H CH2OCH2C≡CH H O Me GbH H CH2OCH2C≡CH H O Et GbH H CH2OCH2C≡CH H O CH2CH＝CH2 GbH H CH2OCH2C≡CH H O CH2C≡CH GbH H CH＝CHCO2Me H O H GaH H CH＝CHCO2Me H S H G3H H CH＝CHCO2Me H O Me GbH H CH＝CHCO2Me H O Et GbH H CH＝CHCO2Me H O CH2CH＝CH2 GbH H CH＝CHCO2Me H O CH2C≡CH GbH H CH＝CHCO2Et H O H GaH H CH＝CHCO2Et H S H G3H H CH＝CHCO2Et H O Me GbH H CH＝CHCO2Et H O Et GbH H CH＝CHCO2Et H O CH2CH＝CH2 GbH H CH＝CHCO2Et H O CH2C≡CH GbH H CH＝CHCO2Pr-n H O H GbH H CH＝CHCO2Pr-n H S H G3H H CH＝CHCN H O H GaH H CH＝CHCN H S H G3H H Ph H O H GaH H Ph H S H G3R1 R2 R3 R4 X M GnH H Ph H O Me GbH H Ph H O Et GbH H Ph H O CH2CH＝CH2 GbH H Ph H O CH2C≡CH GbH H Ph-2-F H O H GaH H Ph-2-F H S H G3H H Ph-3-F H O H GbH H Ph-4-F H O H GbH H Ph-2-Cl H O H GaH H Ph-2-Cl H S H G3H H Ph-3-Cl H O H GbH H Ph-4-Cl H O H GbH H Ph-2-Br H O H GaH H Ph-2-Br H S H G3H H Ph-3-Br H O H GbH H Ph-4-Br H O H GbH H Ph-2-CF3 H O H GaH H Ph-2-CF3 H S H G3H H Ph-3-CF3 H O H GbH H Ph-4-CF3 H O H GbH H Ph-2-Me H O H GaH H Ph-2-Me H S H G3H H Ph-3-Me H O H GbH H Ph-4-Me H O H GbH H Ph-2-Et H O H GaH H Ph-2-Et H S H G3H H Ph-2-OMe H O H GaH H Ph-2-OMe H S H G3H H Ph-3-OMe H O H GbH H Ph-4-OMe H O H GbH H Ph-2-OEt H O H GaH H Ph-2-OEt H S H G3H H Ph-2-CO2Me H O H GaH H Ph-2-CO2Me H S H G3H H Ph-2-CO2Et H O H GaH H Ph-2-CO2Et H S H G3H H Ph-3-CO2Me H O H GbH H Ph-4-CO2Me H O H GbH H CH2Ph H O H GaH H CH2Ph H S H G3R1 R2 R3 R4 X M GnH H CH2Ph H O Me GbH H CH2Ph H O Et GbH H CH2Ph H O CH2CH＝CH2 GbH H CH2Ph H O CH2C≡CH GbH H CH2Ph-2-F H O H GaH H CH2Ph-2-F H S H G3H H CH2Ph-3-F H O H GbH H CH2Ph-4-F H O H GbH H CH2Ph-2-Cl H O H GaH H CH2Ph-2-Cl H S H G3H H CH2Ph-3-Cl H O H GbH H CH2Ph-4-Cl H O H GbH H CH2Ph-2-Br H O H GaH H CH2Ph-2-Br H S H G3H H CH2Ph-3-Br H O H GbH H CH2Ph-4-Br H O H GbH H CH2Ph-2-CF3 H O H GaH H CH2Ph-2-CF3 H S H G3H H CH2Ph-3-CF3 H O H GbH H CH2Ph-4-CF3 H O H GbH H CH2Ph-2-Me H O H GaH H CH2Ph-2-Me H S H G3H H CH2Ph-3-Me H O H GbH H CH2Ph-4-Me H O H GbH H CH2Ph-2-Et H O H GaH H CH2Ph-2-Et H S H G3H H CH2Ph-2-OMe H O H GaH H CH2Ph-2-OMe H S H G3H H CH2Ph-3-OMe H O H GbH H CH2Ph-4-OMe H O H GbH H CH2Ph-2-OEt H O H GaH H CH2Ph-2-OEt H S H G3H H CH2Ph-2-CO2Me H O H GaH H CH2Ph-2-CO2Me H S H G3H H CH2Ph-2-CO2Et H O H GaH H CH2Ph-2-CO2Et H S H G3H H CH2Ph-3-CO2Me H O H GbH H CH2Ph-4-CO2Me H O H GbH H OPh H O H GaH H OPh H S H G3R1 R2 R3 R4 X M GnH H OPh H O Me GbH H OPh H O Et GbH H OPh H O CH2CH＝CH2 GbH H OPh H O CH2C≡CH GbH H OPh-2-Cl H O H GaH H OPh-2-Cl H S H G3H H OPh-3-Cl H O H GbH H OPh-4-Cl H O H GbH H OPh-2-F H O H GaH H OPh-2-F H S H G3H H OPh-3-F H O H GbH H OPh-4-F H O H GbH H OPh-2-CF3 H O H GaH H OPh-2-CF3 H S H G3H H OPh-3-CF3 H O H GbH H OPh-4-CF3 H O H GbH H OPh-2-Me H O H GaH H OPh-2-Me H S H G3H H OPh-3-Me H O H GbH H OPh-4-Me H O H GbH H OPh-2-Et H O H GaH H OPh-2-Et H S H G3H H OPh-2-OMe H O H GaH H OPh-2-OMe H S H G3H H OPh-3-OMe H O H GbH H OPh-4-OMe H O H GbH H OPh-2-OEt H O H GaH H OPh-2-OEt H S H G3H H OPh-2-CO2Me H O H GaH H OPh-2-CO2Me H S H G3H H OPh-3-CO2Me H O H GbH H OPh-4-CO2Me H O H GbH H OPh-2-CO2Et H O H GaH H OPh-2-CO2Et H S H G3H H SPh H O H GaH H SPh H S H G3H H SPh H O Me GbH H SPh H O Et GbH H SPh H O CH2CH＝CH2 GbH H SPh H O CH2C≡CH GbH H CON(Et)2 H S H G3H H CON(Et)2 H O Me CbH H CON(Et)2 H O Et GbR1 R2 R3 R4 X M GnH H SPh-2-Cl H O H GaH H SPh-2-Cl H S H G3H H SPh-3-Cl H O H GbH H SPh-4-Cl H O H GbH H SPh-2-F H O H GaH H SPh-2-F H S H G3H H SPh-3-F H O H GbH H SPh-4-F H O H GbH H SPh-2-CF3 H O H GaH H SPh-2-CF3 H S H G3H H SPh-3-CF3 H O H GbH H SPh-4-CF3 H O H GbH H SPh-2-Me H O H GaH H SPh-2-Me H S H G3H H SPh-3-Me H O H GbH H SPh-4-Me H O H GbH H SPh-2-Et H O H GaH H SPh-2-Et H S H G3H H SPh-2-OMe H O H GaH H SPh-2-OMe H S H G3H H SPh-3-OMe H O H GbH H SPh-4-OMe H O H GbH H SPh-2-OEt H O H GaH H SPh-2-OEt H S H G3H H SPh-2-CO2Me H O H GaH H SPh-2-CO2Me H S H G3H H SPh-3-CO2Me H O H GbH H SPh-4-CO2Me H O H GbH H SPh-2-CO2Et H O H GaH H SPh-2-CO2Et H S H G3H H SO2Ph H O H GaH H SO2Ph H S H G3H H SO2Ph H O Me GbH H SO2Ph H O Et GbH H SO2Ph H O CH2CH＝CH2 GbH H SO2Ph H O CH2C≡CH GbH H SO2Ph-2-Cl H O H GaH H SO2Ph-2-Cl H S H G3H H SO2Ph-3-Cl H O H GbH H CON(Et)2 H O CH2CH＝CH2 GbH H CON(Et)2 H O CH2C≡CH GbH H SO2Ph-4-Cl H O H GbR1 R2 R3 R4 X M GnH H SO2Ph-2-F H O H GaH H SO2Ph-2-F H S H G3H H SO2Ph-3-F H O H GbH H SO2Ph-4-F H O H GbH H SO2Ph-2-CF3 H O H GaH H SO2Ph-2-CF3 H S H G3H H SO2Ph-3-CF3 H O H GbH H SO2Ph-4-CF3 H O H GbH H SO2Ph-2-Me H O H GaH H SO2Ph-2-Me H S H G3H H SO2Ph-3-Me H O H GbH H SO2Ph-4-Me H O H GbH H SO2Ph-2-Et H O H GaH H SO2Ph-2-Et H S H G3H H SO2Ph-2-OMe H O H GaH H SO2Ph-2-OMe H S H G3H H SO2Ph-3-OMe H O H GbH H SO2Ph-4-OMe H O H GbH H SO2Ph-2-OEt H O H GaH H SO2Ph-2-OEt H S H G3H H SO2Ph-2-CO2Me H O H GaH H SO2Ph-2-CO2Me H S H G3H H SO2Ph-3-CO2Me H O H GbH H SO2Ph-4-CO2Me H O H GbH H SO2Ph-2-CO2Et H O H GaH H SO2Ph-2-CO2Et H S H G3H H CONHMe H O H GaH H CONHMe H S H G3H H CONHEt H O H GaH H CONHEt H S H G3H H CONHPr-n H O H GbH H CONHPr-n H S H G3H H CONHPr-i H O H GbH H CONHPr-i H S H G3H H CONHBu-n H O H GbH H CONHBu-sec H O H GbH H CONHBu-t H O H GbH H CON(Me)2 H O H GaH H CON(Me)2 H S H G3H H CON(Pr-n)2 H O H GbH H CON(Pr-n)2 H S H G3H H CON(Et)2 H O H GaR3 R2 R1 R4 X M GnH H F H O H GaH H F H S H G3H H Cl H O H GaH H Cl H S H G3H H Br H O H GaH H Br H S H G3H H I H O H GaH H I H S H G3H H CH＝CH2 H O H GaH H CH＝CH2 H S H G3H H CH2CH＝CH2 H O H GaH H CH2CH＝CH2 H S H G3H H C≡CH H O H GaH H C≡CH H S H G3H H CH2C≡CH H O H GaH H CH2C≡CH H S H G3H H CH2OSO2Me H O H GaH H CH2OSO2Me H S H G3H H CHF2 H O H GaH H CHF2 H S H G3H H CN H O H GaH H CN H S H G3H H NH2 H O H GaH H NH2 H S H G3H H NHCOMe H O H GaH H NHCOMe H S H G3H H CH2NH2 H O H GaH H CH2NH2 H S H G3H H CH2NHCOMe H O H GaH H CH2NHCOMe H S H G3H H CH2OCHF2 H O H GaH H CH2OCHF2 H S H G3H H CF3 H O H GaH H CF3 H S H G3H H CF3 H O Me GbH H CF3 H O Et GbH H CF3 H O CH2CH＝CH2 GbH H CF3 H O CH2C≡CH GbH H NO2 H O H GbH H NO2 H S H G3H H NO2 H O Me GbR3 R2 R1 R4 X M GnH H NO2 H O Et GbH H NO2 H O CH2CH＝CH2GbH H NO2 H O CH2C≡CH GbH H OMe H O H GaH H OMe H S H G3H H OMe H O Me GbH H OMe H O Et GbH H OMe H O CH2CH＝CH2GbH H OMe H O CH2C≡CH GbH H OEt H O H GaH H OEt H S H G3H H OEt H O Me GbH H OEt H O Et GbH H OEt H O CH2CH＝CH2GbH H OEt H O CH2C≡CH GbH H OPr-n H O H GbH H OPr-n H S H G3H H OBu-n H O H GcH H OPen-n H O H GcH H SMe H O H GaH H SMe H S H G3H H SMe H O Me GbH H SMe H O Et GbH H SMe H O CH2CH＝CH2GbH H SMe H O CH2C≡CH GbH H SEt H O H GaH H SEt H S H G3H H SEt H O Me GbH H SEt H O Et GbH H SEt H O CH2CH＝CH2GbH H SEt H O CH2C≡CH GbH H SPr-n H O H GbH H SPr-n H S H G3H H SBu-n H O H GcH H SPen-n H O H GcH H SO2Me H O H GaH H SO2Me H S H G3H H SO2Me H O Me GbH H SO2Me H O Et GbH H SO2Me H O CH2CH＝CH2GbR3 R2 R1 R4 X M GnH H SO2Me H O CH2C≡CH GbH H SO2Et H O H GaH H SO2Et H S H G3H H SO2Et H O Me GbH H SO2Et H O Et GbH H SO2Et H O CH2CH＝CH2GbH H SO2Et H O CH2C≡CH GbH H SO2Pr-n H O H GbH H SO2Pr-n H S H G3H H COMe H O H GaH H COMe H S H G3H H COMe H O Me GbH H COMe H O Et GbH H COMe H O CH2CH＝CH2GbH H COMe H O CH2C≡CH GbH H COEt H O H GaH H COEt H S H G3H H COEt H O Me GbH H COEt H O Et GbH H COEt H O CH2CH＝CH2GbH H COEt H O CH2C≡CH GbH H COPr-n H O H GbH H COPr-n H S H G3H H CO2H H O H GbH H CO2H H S H G3H H CO2Me H O H GaH H CO2Me H S H G3H H CO2Me H O Me GbH H CO2Me H O Et GbH H CO2Me H O CH2CH＝CH2GbH H CO2Me H O CH2C≡CH GbH H CO2Et H O H GaH H CO2Et H S H G3H H CO2Et H O Me GbH H CO2Et H O Et GbH H CO2Et H O CH2CH＝CH2GbH H CO2Ft H O CH2C≡CH GbH H CO2Pr-n H O H GbH H CO2Pr-n H S H G3H H CO2Bu-n H O H GcR3 R2 R1 R4 X M GnH H CO2Pen-n H O H GcH H CH2F H O H GaH H CH2F H S H G3H H CH2F H O Me GbH H CH2F H O Et GbH H CH2F H O CH2CH＝CH2GbH H CH2F H O CH2C≡CH GbH H CH2Cl H O H GaH H CH2Cl H S H G3H H CH2Cl H O Me GbH H CH2Cl H O Et GbH H CH2Cl H O CH2CH＝CH2GbH H CH2Cl H O CH2C≡CH GbH H CH2Br H O H GbH H CH2Br H S H G3H H CH2I H O H GbH H CH2I H S H G3H H CH2CF3 H O H GaH H CH2CF3 H S H G3H H CH2CF3 H O Me GbH H CH2CF3 H O Et GbH H CH2CF3 H O CH2CH＝CH2GbH H CH2CF3 H O CH2C≡CH GbH H CH2CN H O H GaH H CH2CN H S H G3H H CH2CN H O Me GbH H CH2CN H O Et GbH H CH2CN H O CH2OH＝CH2GbH H CH2CN H O CH2C≡CH GbH H CH2OH H O H GbH H CH2OMe H O H GaH H CH2OMe H S H G3H H CH2OMe H O Me GbH H CH2OMe H O Et GbH H CH2OMe H O CH2CH＝CH2GbH H CH2OMe H O CH2C≡CH GbH H CH2OEt H O H GaH H CH2OEt H S H G3H H CH2OEt H O Me GbH H CH2OEt H O Et GbR3 R2 R1 R4 X M GnH H CH2OEt H O CH2CH＝CH2GbH H CH2OEt H O CH2C≡CH GbH H CH2OPr-n H O H GbH H CH2OPr-n H S H G3H H CH2SMe H O H GaH H CH2SMe H S H G3H H CH2SMe H O Me GbH H CH2SMe H O Et GbH H CH2SMe H O CH2CH＝CH2GbH H CH2SMe H O CH2C≡CH GbH H CH2SEt H O H GaH H CH2SEt H S H G3H H CH2SEt H O Me GbH H CH2SEt H O Et GbH H CH2SEt H O CH2CH＝CH2GbH H CH2SEt H O CH2C≡CH GbH H CH2SPr-n H O H GbH H CH2SPr-n H S H G3H H CH2SO2Me H O H GaH H CH2SO2Et H O H GaH H CH2SO2Me H S H G3H H CH2SO2Et H S H G3H H CH2COMe H O H GaH H CH2COMe H S H G3H H CH2COMe H O Me GbH H CH2COMe H O Et GbH H CH2COMe H O CH2CH＝CH2GbH H CH2COMe H O CH2C≡CH GbH H CH2COEt H O H GaH H CH2COEt H S H G3H H CH2COEt H O Me GbH H CH2COEt H O Et GbH H CH2COEt H O CH2CH＝CH2GbH H CH2COEt H O CH2C≡CH GbH H CH2COPr-n H O H GbH H CH2COPr-n H S H G3H H CH2CO2H H O H GbH H CH2CO2H H S H G3H H CH2CO2Me H O H GaH H CH2CO2Me H S H G3R3 R2 R1 R4 X M GnH H CH2CO2Me H O Me GbH H CH2CO2Me H O Et GbH H CH2CO2Me H O CH2CH＝CH2 GbH H CH2CO2Me H O CH2C≡CH GbH H CH2CO2Et H O H GaH H CH2CO2Et H S H G3H H CH2CO2Et H O Me GbH H CH2CO2Et H O Et GbH H CH2CO2Et H O CH2CH＝CH2GbH H CH2CO2Et H O CH2C≡CH GbH H CH2CO2Pr-n H O H GbH H CH2CO2Pr-n H S H G3H H CH2OCH2CH＝CH2 H O H GbH H CH2OCH2CH＝CH2 H O Me GbH H CH2OCH2CH＝CH2 H O Et GbH H CH2OCH2CH＝CH2 H O CH2CH＝CH2GbH H CH2OCH2CH＝CH2 H O CH2C≡CH GbH H CH2OCH2C≡CH H O H GbH H CH2OCH2C≡CH H O Me GbH H CH2OCH2C≡CH H O Et GbH H CH2OCH2C≡CH H O CH2CH＝CH2 GbH H CH2OCH2C≡CH H O CH2C≡CH GbH H CH＝CHCO2Me H O H GaH H CH＝CHCO2Me H S H G3H H CH＝CHCO2Me H O Me GbH H CH＝CHCO2Me H O Et GbH H CH＝CHCO2Me H O CH2CH＝CH2 GbH H CH＝CHCO2Me H O CH2C≡CH GbH H CH＝CHCO2Et H O H GaH H CH＝CHCO2Et H S H G3H H CH＝CHCO2Et H O Me GbH H CH＝CHCO2Et H O Et GbH H CH＝CHCO2Et H O CH2CH＝CH2 GbH H CH＝CHCO2Et H O CH2C≡CH GbH H GH＝CHCO2Pr-n H O H GbH H CH＝CHCO2Pr-n H S H G3H H CH＝CHCN H O H GaH H CH＝CHCN H S H G3H H Ph H O H GaH H Ph H S H G3R3 R2 R1 R4 X M GnH H Ph H O Me GbH H Ph H O Me GbH H Ph H O CH2CH＝CH2GbH H Ph H O CH2C≡CH GbH H Ph-2-F H O H GaH H Ph-2-F H S H G3H H Ph-3-F H O H GbH H Ph-4-F H O H GbH H Ph-2-Cl H O H GaH H Ph-2-Cl H S H G3H H Ph-3-Cl H O H GbH H Ph-4-Cl H O H GbH H Ph-2-Br H O H GaH H Ph-2-Br H S H G3H H Ph-3-Br H O H GbH H Ph-4-Br H O H GbH H Ph-2-CF3 H O H GaH H Ph-2-CF3 H S H G3H H Ph-3-CF3 H O H GbH H Ph-4-CF3 H O H GbH H Ph-2-Me H O H GaH H Ph-2-Me H S H G3H H Ph-3-Me H O H GbH H Ph-4-Me H O H GbH H Ph-2-Et H O H GaH H Ph-2-Et H S H G3H H Ph-2-OMe H O H GaH H Ph-2-OMe H S H G3H H Ph-3-OMe H O H GbH H Ph-4-OMe H O H GbH H Ph-2-OEt H O H GaH H Ph-2-OEt H S H G3H H Ph-2-CO2Me H O H GaH H Ph-2-CO2Me H S H G3H H Ph-2-CO2Et H O H GaH H Ph-2-CO2Et H S H G3H H Ph-3-CO2Me H O H GbH H Ph-4-CO2Me H O H GbH H CH2Ph H O H GaH H CH2Ph H S H G3R3 R2 R1 R4 X M GnH H CH2Ph H O Me GbH H CH2Ph H O Et GbH H CH2Ph H O CH2CH＝CH2GbH H CH2Ph H O CH2C≡CH GbH H CH2Ph-2-F H O H GaH H CH2Ph-2-F H S H G3H H CH2Ph-3-F H O H GbH H CH2Ph-4-F H O H GbH H CH2Ph-2-Cl H O H GaH H CH2Ph-2-Cl H S H G3H H CH2Ph-3-Cl H O H GbH H CH2Ph-4-Cl H O H GbH H CH2Ph-2-Br H O H GaH H CH2Ph-2-Br H S H G3H H CH2Ph-3-Br H O H GbH H CH2Ph-4-Br H O H GbH H CH2Ph-2-CF3 H O H GaH H CH2Ph-2-CF3 H S H G3H H CH2Ph-3-CF3 H O H GbH H CH2Ph-4-CF3 H O H GbH H CH2Ph-2-Me H O H GaH H CH2Ph-2-Me H S H G3H H CH2Ph-3-Me H O H GbH H CH2Ph-4-Me H O H GbH H CH2Ph-2-Et H O H GaH H CH2Ph-8-Et H S H G3H H CH2Ph-2-OMe H O H GaH H CH2Ph-2-OMe H S H G3H H CH2Ph-3-OMe H O H GbH H CH2Ph-4-OMe H O H GbH H CH2Ph-2-OEt H O H GaH H CH2Ph-2-OEt H S H G3H H CH2Ph-2-CO2Me H O H GaH H CH2Ph-2-CO2Me H S H G3H H CH2Ph-2-CO2Et H O H GaH H CH2Ph-2-CO2Et H S H G3H H CH2Ph-3-CO2Me H O H GbH H CH2Ph-4-CO2Me H O H GbH H OPh H O H GaH H OPh H S H G3R3 R2 R1 R4 X M GnH H OPh H O Me GbH H OPh H O Et GbH H OPh H O CH2CH＝CH2 GbH H OPh H O CH2C≡CH GbH H OPh-2-Cl H O H GaH H OPh-2-Cl H S H G3H H OPh-3-Cl H O H GbH H OPh-4-Cl H O H GbH H OPh-2-F H O H GaH H OPh-2-F H S H G3H H OPh-3-F H O H GbH H OPh-4-F H O H GbH H OPh-2-CF3 H O H GaH H OPh-2-CF3 H S H G3H H OPh-3-CF3 H O H GbH H OPh-4-CF3 H O H GbH H OPh-2-Me H O H GaH H OPh-2-Me H S H G3H H OPh-3-Me H O H GbH H OPh-4-Me H O H GbH H OPh-2-Et H O H GaH H OPh-2-Et H S H G3H H OPh-2-OMe H O H GaH H OPh-2-OMe H S H G3H H OPh-3-OMe H O H GbH H OPh-4-OMe H O H GbH H OPh-2-OEe H O H GaH H OPh-2-OEt H S H G3H H OPh-2-CO2Me H O H GaH H OPh-2-CO2Me H S H G3H H OPh-3-CO2Me H O H GbH H OPh-4-CO2Me H O H GbH H OPh-2-CO2Et H O H GaH H OPh-2-CO2Et H S H G3H H SPh H O H GaH H SPh H S H G3H H SPh H O Me GbH H SPh H O Et GbH H SPh H O CH2CH＝CH2 GbH H SPh H O CH2C≡CH GbH H CON(Et)2 H S H G3H H CON(Et)2 H O Me GbH H CON(Et)2 H O Et GbR3 R2 R1 R4 X M GnH H SPh-2-Cl H O H GaH H SPh-2-Cl H S H G3H H SPh-3-Cl H O H GbH H SPh-4-Cl H O H GbH H SPh-2-F H O H GaH H SPh-2-F H S H G3H H SPh-3-F H O H GbH H SPh-4-F H O H GbH H SPh-2-CF3 H O H GaH H SPh-2-CF3 H S H G3H H SPh-3-CF3 H O H GbH H SPh-4-CF3 H O H GbH H SPh-2-Me H O H GaH H SPh-2-Me H S H G3H H SPh-3-Me H O H GbH H SPh-4-Me H O H GbH H SPh-2-Et H O H GaH H SPh-2-Et H S H G3H H SPh-2-OMe H O H GaH H SPh-2-OMe H S H G3H H SPh-3-OMe H O H GbH H SPh-4-OMe H O H GbH H SPh-2-OEt H O H GaH H SPh-2-OEt H S H G3H H SPh-2-CO2Me H O H GaH H SPh-2-CO2Me H S H G3H H SPh-3-CO2Me H O H GbH H SPh-4-CO2Me H O H GbH H SPh-2-CO2Et H O H GaH H SPh-2-CO2Et H S H G3H H SO2Ph H O H GaH H SO2Ph H S H G3H H SO2Ph H O Me GbH H SO2Ph H O Et GbH H SO2Ph H O CH2CH＝CH2GbH H SO2Ph H O CH2C≡CH GbH H SO2Ph-2-Cl H O H GaH H SO2Ph-2-Cl H S H G3H H SO2Ph-3-Cl H O H GbH H CON(Et)2 H O CH2CH＝CH2GbH H CON(Et)2 H O CH2C≡CH GbH H SO2Ph-4-Cl H O H GbR3 R2 R1 R4 X M GnH H SO2Ph-2-F H O H GaH H SO2Ph-2-F H S H G3H H SO2Ph-3-F H O H GbH H SO2Ph-4-F H O H GbH H SO2Ph-2-CF3 H O H GaH H SO2Ph-2-CF3 H S H G3H H SO2Ph-3-CF3 H O H GbH H SO2Ph-4-CF3 H O H GbH H SO2Ph-2-Me H O H GaH H SO2Ph-2-Me H S H G3H H SO2Ph-3-Me H O H GbH H SO2Ph-4-Me H O H GbH H SO2Ph-2-Et H O H GaH H SO2Ph-2-Et H S H G3H H SO2Ph-2-OMe H O H GaH H SO2Ph-2-OMe H S H G3H H SO2Ph-3-OMe H O H GbH H SO2Ph-4-OMe H O H GbH H SO2Ph-2-OEt H O H GaH H SO2Ph-2-OEt H S H G3H H SO2Ph-2-CO2Me H O H GaH H SO2Ph-2-CO2Me H S H G3H H SO2Ph-3-CO2Me H O H GbH H SO2Ph-4-CO2Me H O H GbH H SO2Ph-2-CO2Et H O H GaH H SO2Ph-2-CO2Et H S H G3H H CONHMe H O H GaH H CONHMe H S H G3H H CONHEt H O H GaH H CONHEt H S H G3H H CONHPr-n H O H GbH H CONHPr-n H S H G3H H CONHPr-i H O H GbH H CONHPr-i H S H G3H H CONHBu-n H O H GbH H CONHBu-sec H O H GbH H CONHBu-t H O H GbH H CON(Me)2 H O H GaH H CON(Me)2 H S H G3H H CON(Pr-n)2 H O H GbH H CON(Pr-n)2 H S H G3H H CON(Et)2 H O H GaR4 R3 R2 R1 X M GnH H F H O H GaH H F H S H G3H H Cl H O H GaH H Cl H S H G3H H Br H O H GaH H Br H S H G3H H I H O H GaH H I H S H G3H H CH＝CH2 H O H GaH H CH＝CH2 H S H G3H H CH2CH＝CH2 H O H GaH H CH2CH＝CH2 H S H G3H H C≡CH H O H GaH H C≡CH H S H G3H H CH2C≡CH H O H GaH H CH2C≡CH H S H G3H H CH2OSO2Me H O H GaH H CH2OSO2Me H S H G3H H CHF2 H O H GaH H CHF2 H S H G3H H CN H O H GaH H CN H S H G3H H NH2 H O H GaH H NH2 H S H G3H H NHCOMe H O H GaH H NHCOMe H S H G3H H CH2NH2 H O H GaH H CH2NH2 H S H G3H H CH2NHCOMe H O H GaH H CH2NHCOMe H S H G3H H CH2OCHF2 H O H GaH H CH2OCHF2 H S H G3H H CF3 H O H CaH H CF3 H S H G3H H CF3 H O Me GbH H CF3 H O Et GbH H CF3 H O CH2CH＝CH2 GbH H CF3 H O CH2C≡CH GbH H NO2 H O H GbH H NO2 H S H G3H H NO2 H O Me GbR4 R3 R2 R1 X M GnH H NO2 H O Et GbH H NO2 H O CH2CH＝CH2GbH H NO2 H O CH2C≡CH GbH H OMe H O H GaH H OMe H S H G3H H OMe H O Me GbH H OMe H O Et GbH H OMe H O CH2CH＝CH2GbH H OMe H O CH2C≡CH GbH H OEt H O H GaH H OEt H S H G3H H OEt H O Me GbH H OEt H O Et GbH H OEt H O CH2CH＝CH2GbH H OEt H O CH2C≡CH GbH H OPr-n H O H GbH H OPr-n H S H G3H H OBu-n H O H GcH H OPen-n H O H GcH H SMe H O H GaH H SMe H S H G3H H SMe H O Me GbH H SMe H O Et GbH H SMe H O CH2CH＝CH2GbH H SMe H O CH2C≡CH GbH H SEt H O H GaH H SEt H S H G3H H SEt H O Me GbH H SEt H O Et GbH H SEt H O CH2CH＝CH2GbH H SEt H O CH2C≡CH GbH H SPr-n H O H GbH H SPr-n H S H G3H H SBu-n H O H GcH H SPen-n H O H GcH H SO2Me H O H GaH H SO2Me H S H G3H H SO2Me H O Me GbH H SO2Me H O Et GbH H SO2Me H O CH2CH＝CH2GbR4 R3 R2 R1 X M GnH H SO2Me H O CH2C≡CH GbH H SO2Et H O H GaH H SO2Et H S H G3H H SO2Et H O Me GbH H SO2Et H O Et GbH H SO2Et H O CH2CH＝CH2GbH H SO2Et H O CH2C≡CH GbH H SO2Pr-n H O H GbH H SO2Pr-n H S H G3H H COMe H O H GaH H COMe H S H G3H H COMe H O Me GbH H COMe H O Et GbH H COMe H O CH2CH＝CH2GbH H COMe H O CH2C≡CH GbH H COEt H O H GaH H COEt H S H G3H H COEt H O Me GbH H COEt H O Et GbH H COEt H O CH2CH＝CH2GbH H COEt H O CH2C≡CH GbH H COPr-n H O H GbH H COPr-n H S H G3H H CO2H H O H GbH H CO2H H S H G3H H CO2Me H O H GaH H CO2Me H S H G3H H CO2Me H O Me GbH H CO2Me H O Et GbH H CO2Me H O CH2CH＝CH2GbH H CO2Me H O CH2C≡CH GbH H CO2Et H O H GaH H CO2Et H S H G3H H CO2Et H O Me GbH H CO2Et H O Et GbH H CO2Et H O CH2CH＝CH2GbH H CO2Et H O CH2C≡CH GbH H CO2Pr-n H O H GbH H CO2Pr-n H S H G3H H CO2Bu-n H O H GcR4 R3 R2 R1 X M GnH H CO2Pen-n H O H GcH H CH2F H O H GaH H CH2F H S H G3H H CH2F H O Me GbH H CH2F H O Et GbH H CH2F H O CH2CH＝CH2GbH H CH2F H O CH2C≡CH GbH H CH2Cl H O H GaH H CH2Cl H S H G3H H CH2Cl H O Me GbH H CH2Cl H O Et GbH H CH2Cl H O CH2CH＝CH2GbH H CH2Cl H O CH2C≡CH GbH H CH2Br H O H GbH H CH2Br H S H G3H H CH2I H O H GbH H CH2I H S H G3H H CH2CF3 H O H GaH H CH2CF3 H S H G3H H CH2CF3 H O Me GbH H CH2CF3 H O Et GbH H CH2CF3 H O CH2CH＝CH2GbH H CH2CF3 H O CH2C≡CH GbH H CH2CN H O H GaH H CH2CN H S H G3H H CH2CN H O Me GbH H CH2CN H O Et GbH H CH2CN H O CH2CH＝CH2GbH H CH2CN H O CH2C≡CH GbH H CH2OH H O H GbH H CH2OMe H O H GaH H CH2OMe H S H G3H H CH2OMe H O Me GbH H CH2OMe H O Et GbH H CH2OMe H O CH2CH＝CH2GbH H CH2OMe H O CH2C≡CH GbH H CH2OEt H O H GaH H CH2OEt H S H G3H H CH2OEt H O Me GbH H CH2OEt H O Et GbR4 R3 R2 R1 X M GnH H CH2OEt H O CH2CH＝CH2GbH H CH2OEt H O CH2C≡CH GbH H CH2OPr-n H O H GbH H CH2OPr-n H S H G3H H CH2SMe H O H GaH H CH2SMe H S H G3H H CH2SMe H O Me GbH H CH2SMe H O Et GbH H CH2SMe H O CH2CH＝CH2Gbh H CH2SMe H O CH2C≡CH GbH H CH2SEt H O H GaH H CH2SEt H S H G3H H CH2SEt H O Me GbH H CH2SEt H O Et GbH H CH2SEt H O CH2CH＝CH2GbH H CH2SEt H O CH2C≡CH GbH H CH2SPr-n H O H GbH H CH2SPr-n H S H G3H H CH2SO2Me H O H GaH H CH2SO2Et H O H GaH H CH2SO2Me H S H G3H H CH2SO2Et H S H G3H H CH2COMe H O H GaH H CH2COMe H S H G3H H CH2COMe H O Me GbH H CH2COMe H O Et GbH H CH2COMe H O CH2CH＝CH2GbH H CH2COMe H O CH2C≡CH GbH H CH2COEt H O H GaH H CH2COEt H S H G3H H CH2COEt H O Me GbH H CH2COEt H O Et GbH H CH2COEt H O CH2CH＝CH2GbH H CH2COEt H O CH2C≡CH GbH H CH2COPr-n H O H GbH H CH2COPr-n H S H G3H H CH2CO2H H O H GbH H CH2CO2H H S H G3H H CH2CO2Me H O H GaH H CH2CO2Me H S H G3R4 R3 R2 R1 X M GnH H CH2CO2Me H O Me GbH H CH2CO2Me H O Et GbH H CH2CO2Me H O CH2CH＝CH2GbH H CH2CO2Me H O CH2C≡CH GbH H CH2CO2Et H O H GaH H CH2CO2Et H S H G3H H CH2CO2Et H O Me GbH H CH2CO2Et H O Et GbH H CH2CO2Et H O CH2CH＝CH2GbH H CH2CO2Et H O CH2C≡CH GbH H CH2CO2Pr-n H O H GbH H CH2CO2Pr-n H S H G3H H CH2OCH2CH＝CH2 H O H GbH H CH2OCH2CH＝CH2 H O Me GbH H CH2OCH2CH＝CH2 H O Et GbH H CH2OCH2GH＝CH2 H O CH2CH＝CH2GbH H CH2OCH2CH＝CH2 H O CH2C≡CH GbH H CH2OCH2C≡CH H O H GbH H CH2OCH2C≡CH H O Me GbH H CH2OCH2C≡CH H O Et GbH H CH2OCH2C≡CH H O CH2CH＝CH2GbH H CH2OCH2C≡CH H O CH2C≡CH GbH H CH＝CHCO2Me H O H GaH H CH＝CHCO2Me H S H G3H H CH＝CHCO2Me H O Me GbH H CH＝CHCO2Me H O Et GbH H CH＝CHCO2Me H O CH2CH＝CH2GbH H CH＝CHCO2Me H O CH2C≡CH GbH H CH＝CHCO2Et H O H GaH H CH＝CHCO2Et H S H G3H H CH＝CHCO2Et H O Me GbH H CH＝CHCO2Et H O Et GbH H CH＝CHCO2Et H O CH2CH＝CH2GbH H CH＝CHCO2Et H O CH2C≡CH GbH H CH＝CHCO2Pr-n H O H GbH H CH＝CHCO2Pr-n H S H G3H H CH＝CHCN H O H GaH H CH＝CHCN H S H G3H H Ph H O H GaH H Ph H S H G3R4 R3 R2 R1 X M GnH H Ph H O Me GbH H Ph H O Et GbH H Ph H O CH2CH＝CH2GbH H Ph H O CH2C≡CH GbH H Ph-2-F H O H GaH H Ph-2-F H S H G3H H Ph-3-F H O H GbH H Ph-4-F H O H GbH H Ph-2-Cl H O H GaH H Ph-2-Cl H S H G3H H Ph-3-Cl H O H GbH H Ph-4-Cl H O H GbH H Ph-2-Br H O H GaH H Ph-2-Br H S H G3H H Ph-3-Br H O H GbH H Ph-4-Br H O H GbH H Ph-2-CF3 H O H GaH H Ph-2-CF3 H S H G3H H Ph-3-CF3 H O H GbH H Ph-4-CF3 H O H GbH H Ph-2-Me H O H GaH H Ph-2-Me H S H G3H H Ph-3-Me H O H GbH H Ph-4-Me H O H GbH H Ph-2-Et H O H GaH H Ph-2-Et H S H G3H H Ph-2-OMe H O H GaH H Ph-2-OMe H S H G3H H Ph-3-OMe H O H GbH H Ph-4-OMe H O H GbH H Ph-2-OEt H O H GaH H Ph-2-OEt H S H G3H H Ph-2-CO2Me H O H GaH H Ph-2-CO2Me H S H G3H H Ph-2-CO2Et H O H GaH H Ph-2-CO2Et H S H G3H H Ph-3-CO2Me H O H GbH H Ph-4-CO2Me H O H GbH H CH2Ph H O H GaH H CH2Ph H S H G3R4 R3 R2 R1 X M GnH H CH2Ph H O Me GbH H CH2Ph H O Et GbH H CH2Ph H O CH2CH＝CH2GbH H CH2Ph H O GH2C≡CH GbH H CH2Ph-2-F H O H GaH H CH2Ph-2-F H S H G3H H CH2Ph-3-F H O H GbH H CH2Ph-4-F H O H GbH H CH2Ph-2-Cl H O H GaH H CH2Ph-2-Cl H S H G3H H CH2Ph-3-Cl H O H GbH H CH2Ph-4-Cl H O H GbH H CH2Ph-2-Br H O H GaH H CH2Ph-2-Br H S H G3H H CH2Ph-3-Br H O H GbH H CH2Ph-4-Br H O H GbH H CH2Ph-2-CF3 H O H GaH H CH2Ph-2-CF3 H S H G3H H CH2Ph-3-CF3 H O H GbH H CH2Ph-4-CF3 H O H GbH H CH2Ph-2-Me H O H GaH H CH2Ph-2-Me H S H G3H H CH2Ph-3-Me H O H GbH H CH2Ph-4-Me H O H GbH H CH2Ph-2-Et H O H GaH H CH2Ph-2-Et H S H G3H H CH2Ph-2-OMe H O H GaH H CH2Ph-2-OMe H S H G3H H CH2Ph-3-OMe H O H GbH H CH2Ph-4-OMe H O H GbH H CH2Ph-2-OEt H O H GaH H CH2Ph-2-OEt H S H G3H H CH2Ph-2-CO2Me H O H GaH H CH2Ph-2-CO2Me H S H G3H H CH2Ph-2-CO2Et H O H GaH H CH2Ph-2-CO2Et H S H G3H H CH2Ph-3-CO2Me H O H GbH H CH2Ph-4-CO2Me H O H GbH H OPh H O H GaH H OPh H S H G3R4 R3 R2 R1 X M GnH H OPh H O Me GbH H OPh H O Et GbH H OPh H O CH2CH＝CH2 GbH H OPh H O CH2C≡CH GbH H OPh-2-Cl H O H GaH H OPh-2-Cl H S H G3H H OPh-3-Cl H O H GbH H OPh-4-Cl H O H GbH H OPh-2-F H O H GaH H OPh-2-F H S H G3H H OPh-3-F H O H GbH H OPh-4-F H O H GbH H OPh-2-CF3 H O H GaH H OPh-2-CF3 H S H G3H H OPh-3-CF3 H O H GbH H OPh-4-CF3 H O H GbH H OPh-2-Me H O H GaH H OPh-2-Me H S H G3H H OPh-3-Me H O H GbH H OPh-4-Me H O H GbH H OPh-2-Et H O H GaH H OPh-2-Et H S H G3H H OPh-2-OMe H O H GaH H OPh-2-OMe H S H G3H H OPh-3-OMe H O H GbH H OPh-4-OMe H O H GbH H OPh-2-OEt H O H GaH H OPh-2-OEt H S H G3H H OPh-2-CO2Me H O H GaH H OPh-2-CO2Me H S H G3H H OPh-3-CO2Me H O H GbH H OPh-4-CO2Me H O H GbH H OPh-2-CO2Et H O H GaH H OPh-2-CO2Et H S H G3H H SPh H O H GaH H SPh H S H G3H H SPh H O Me GbH H SPb H O Et GbH H SPh H O CH2CH＝CH2 GbH H SPh H O CH2C≡CH GbH H CON(Et)2 H S H G3H H CON(Et)2 H O Me GbH H CON(Et)2 H O Et GbR4 R3 R2 R1 X M GnH H SPh-2-Cl H O H GaH H SPh-2-Cl H S H G3H H SPh-3-Cl H O H GbH H SPh-4-Cl H O H GbH H SPh-2-F H O H GaH H SPh-2-F H S H G3H H SPh-3-F H O H GbH H SPh-4-F H O H GbH H SPh-2-CF3 H O H GaH H SPh-2-CF3 H S H G3H H SPh-3-CF3 H O H GbH H SPh-4-CF3 H O H GbH H SPh-2-Me H O H GaH H SPh-2-Me H S H G3H H SPh-3-Me H O H GbH H SPh-4-Me H O H GbH H SPh-2-Et H O H GaH H SPh-2-Et H S H G3H H SPh-2-OMe H O H GaH H SPh-2-OMe H S H G3H H SPh-3-OMe H O H GbH H SPh-4-OMe H O H GbH H SPh-2-OEt H O H GaH H SPh-2-OEt H S H G3H H SPh-2-CO2Me H O H GaH H SPh-2-CO2Me H S H G3H H SPh-3-CO2Me H O H GbH H SPh-4-CO2Me H O H GbH H SPh-2-CO2Et H O H GaH H SPh-2-CO2Et H S H G3H H SO2Ph H O H GaH H SO2Ph H S H G3H H SO2Ph H O Me GbH H SO2Ph H O Et GbH H SO2Ph H O CH2CH＝CH2 GbH H SO2Ph H O CH2C≡CH GbH H SO2Ph-2-Cl H O H GaH H SO2Ph-2-Cl H S H G3H H SO2Ph-3-Cl H O H GbH H CON(Et)2 H O CH2CH＝CH2 GbH H CON(Et)2 H O CH2C≡CH GbH H SO2Ph-4-Cl H O H GbR4 R3 R2 R1 X M GnH H SO2Ph-2-F H O H GaH H SO2Ph-2-F H S H G3H H SO2Ph-3-F H O H GbH H SO2Ph-4-F H O H GbH H SO2Ph-2-CF3 H O H GaH H SO2Ph-2-CF3 H S H G3H H SO2Ph-3-CF3 H O H GbH H SO2Ph-4-CF3 H O H GbH H SO2Ph-2-Me H O H GaH H SO2Ph-2-Me H S H G3H H SO2Ph-3-Me H O H GbH H SO2Ph-4-Me H O H GbH H SO2Ph-2-Et H O H GaH H SO2Ph-2-Et H S H G3H H SO2Ph-2-OMe H O H GaH H SO2Ph-2-OMe H S H G3H H SO2Ph-3-OMe H O H GbH H SO2Ph-4-OMe H O H GbH H SO2Ph-2-OEt H O H GaH H SO2Ph-2-OEt H S H G3H H SO2Ph-2-CO2Me H O H GaH H SO2Ph-2-CO2Me H S H G3H H SO2Ph-3-CO2Me H O H GbH H SO2Ph-4-CO2Me H O H GbH H SO2Ph-2-CO2Et H O H GaH H SO2Ph-2-CO2Et H S H G3H H CONHMe H O H GaH H CONHMe H S H G3H H CONHEt H O H GaH H CONHEt H S H G3H H CONHPr-n H O H GbH H CONHPr-n H S H G3H H CONHPr-i H O H GbH H CONHPr-i H S H G3H H CONHBu-n H O H GbH H CONHBu-sec H O H GbH H CONHBu-t H O H GbH H CON(Me)2 H O H GaH H CON(Me)2 H S H G3H H CON(Pr-n)2 H O H GbH H CON(Pr-n)2 H S H G3H H CON(Et)2 H O H GaR1 R2 R3 R4 X M GnMe Me H H O H GaMe Me H H S H G3Me H Me H O H GaMe H Me H S H G3Me Et H H O H GaMe Et H H S H G3Me H Et H O H GaMe H Et H S H G3Me Pr-n H H O H GaMe Pr-n H H S H G3Me H Pr-n H O H GaMe H Pr-n H S H G3Me Pr-i H H O H GaMe Pr-i H H S H G3Me H Pr-i H O H GaMe H Pr-i H S H G3Me Bu-n H H O H GaMe Bu-n H H S H G3Me H Bu-n H O H GaMe H Bu-n H S H G3Et Me H H O H GaEt Me H H S H G3Et H Me H O H GaEt H Me H S H G3Et Et H H O H GaEt Et H H S H G3Et H Et H O H GaEt H Et H S H G3Et Pr-n H H O H GaEt Pr-n H H S H G3Et H Pr-n H O H GaEt H Pr-n H S H G3Et Pr-i H H O H GaEt Pr-i H H S H G3Et H Pr-i H O H GaEt H Pr-i H S H G3Et Bu-n H H O H GaEt Bu-n H H S H G3Et H Bu-n H O H GaEt H Bu-n H S H G3R1 R2 R3 R4 X M GnPr-n Me H H O H GaPr-n Me H H S H G3Pr-n H Me H O H GaPr-n H Me H S H G3Pr-n Et H H O H GaPr-n Et H H S H G3Pr-n H Et H O H GaPr-n H Et H S H G3Pr-n Pr-n H H O H GaPr-n Pr-n H H S H G3Pr-n H Pr-n H O H GaPr-n H Pr-n H S H G3Pr-n Pr-i H H O H GaPr-n Pr-i H H S H G3Pr-n H Pr-i H O H GaPr-n H Pr-i H S H G3Pr-n Bu-n H H O H GaPr-n Bu-n H H S H G3Pr-n H Bu-n H O H GaPr-n H Bu-n H S H G3Pr-i Me H H O H GaPr-i Me H H S H G3Pr-i H Me H O H GaPr-i H Me H S H G3Pr-i E H H O H GaPr-i Et H H S H G3Pr-i H Et H O H GaPr-i H Et H S H G3Pr-i Pr-n H H O H GaPr-i Pr-n H H S H G3Pr-i H Pr-n H O H GaPr-i H Pr-n H S H G3Pr-i Pr-i H H O H GaPr-i Pr-i H H S H G3Pr-i H Pr-i H O H GaPr-i H Pr-i H S H G3Pr-i Bu-n H H O H GaPr-i Bu-n H H S H G3Pr-i H Bu-n H O H GaPr-i H Bu-n H S H G3R1 R2 R3 R4 X M GnBu-n Me H H O H GaBu-n Me H H S H G3Bu-n H Me H O H GaBu-n H Me H S H G3Bu-n Et H H O H GaBu-n Et H H S H G3Bu-n H Et H O H GaBu-n H Et H S H G3Bu-n Pr-n H H O H GaBu-n Pr-n H H S H G3Bu-n H Pr-n H O H GaBu-n H Pr-n H S H G3Bu-n Pr-i H H O H GaBu-n Pr-i H H S H G3Bu-n H Pr-i H O H GaBu-n H Pr-i H S H G3Bu-n Bu-n H H O H GaBu-n Bu-n H H S H G3Bu-n H Bu-n H O H GaBu-n H Bu-n H S H G3H Me Me H O H GaH Me Me H S H G3H Me Et H O H GaH Me Et H S H G3H Me Pr-n H O H GaH Me Pr-n H S H G3H Me Pr-i H O H GaH Me Pr-i H S H G3H Me Bu-n H O H GaH Me Bu-n H S H G3H Et Me H O H GaH Et Me H S H G3H Et Et H O H GaH Et Et H S H G3H Et Pr-n H O H GaH Et Pr-n H S H G3H Et Pr-i H O H GaH Et Pr-i H S H G3H Et Bu-n H O H GaH Et Bu-n H S H G3R1 R2 R3 R4 X M GnH Pr-n Me H O H GaH Pr-n Me H S H G3H Pr-n Et H O H GaH Pr-n Et H S H G3H Pr-n Pr-n H O H GaH Pr-n Pr-n H S H G3H Pr-n Pr-i H O H GaH Pr-n Pr-i H S H G3H Pr-n Bu-n H O H GaH Pr-n Bu-n H S H G3H Pr-i Me H O H GaH Pr-i Me H S H G3H Pr-i Et H O H GaH Pr-i Et H S H G3H Pr-i Pr-n H O H GaH Pr-i Pr-n H S H G3H Pr-i Pr-i H O H GaH Pr-i Pr-i H S H G3H Pr-i Bu-n H O H GaH Pr-i Bu-n H S H G3H Bu-n Me H O H GaH Bu-n Me H S H G3H Bu-n Et H O H GaH Bu-n Et H S H G3H Bu-n Pr-n H O H GaH Bu-n Pr-n H S H G3H Bu-n Pr-i H O H GaH Bu-n Pr-i H S H G3H Bu-n Bu-n H O H GaH Bu-n Bu-n H S H G3Me Me Me H O H GaMe Me Me H S H G3Me Me Et H O H GaMe Me Et H S H G3Me Me Pr-n H O H GaMe Me Pr-n H S H G3Me Me Pr-i H O H GaMe Me Pr-i H O H G3Me Me Bu-n H O H GaMe Me Bu-n H S H G3R1 R2 R3 R4 X M GnMe Et Me H O H GaMe Et Me H S H G3Me Et Et H O H GaMe Et Et H S H G3Me Et Pr-n H O H GaMe Et Pr-n H S H G3Me Et Pr-i H O H GaMe Et Pr-i H S H G3Me Et Bu-n H O H GaMe Et Bu-n H S H G3Me Pr-n Me H O H GaMe Pr-n Me H S H G3Me Pr-n Et H O H GaMe Pr-n Et H S H G3Me Pr-n Pr-n H O H GaMe Pr-n Pr-n H S H G3Me Pr-n Pr-i H O H GaMe Pr-n Pr-i H S H G3Me Pr-n Bu-n H O H GaMe Pr-n Bu-n H S H G3Me Pr-i Me H O H GaMe Pr-i Me H S H G3Me Pr-i Et H O H GaMe Pr-i Et H S H G3Me Pr-i Pr-n H O H GaMe Pr-i Pr-n H S H G3Me Pr-i Pr-i H O H GaMe Pr-i Pr-i H S H G3Me Pr-i Bu-n H O H GaMe Pr-i Bu-n H S H G3Me Bu-n Me H O H GaMe Bu-n Me H S H G3Me Bu-n Et H O H GaMe Bu-n Et H S H G3Me Bu-n Pr-n H O H GaMe Bu-n Pr-n H S H G3Me Bu-n Pr-i H O H GaMe Bu-n Pr-i H S H G3Me Bu-n Bu-n H O H GaMe Bu-n Bu-n H S H G3R1 R2 R3 R4 X M GnEt Me Me H O H GaEt Me Me H S H G3Et Me Et H O H GaEt Me Et H S H G3Et Me Pr-n H O H GaEt Me Pr-n H S H G3Et Me Pr-i H O H GaEt Me Pr-i H S H G3Et Me Bu-n H O H GaEt Me Bu-n H S H G3Et Et Me H O H GaEt Et Me H S H G3Et Et Et H O H GaEt Et Et H S H G3Et Et Pr-n H O H GaEt Et Pr-n H S H G3Et Et Pr-i H O H GaEt Et Pr-i H S H G3Et Et Bu-n H O H GaEt Et Bu-n H S H G3Et Pr-n Me H O H GaEt Pr-n Me H S H G3Et Pr-n Et H O H GaEt Pr-n Et H S H G3Et Pr-n Pr-n H O H GaEt Pr-n Pr-n H S H G3Et Pr-n Pr-i H O H GaEt Pr-n Pr-i H S H G3Et Pr-n Bu-n H O H GaEt Pr-n Bu-n H S H G3Et Pr-i Me H O H GaEt Pr-i Me H S H G3Et Pr-i Et H O H GaEt Pr-i Et H S H G3Et Pr-i Pr-n H O H GaEt Pr-i Pr-n H S H G3Et Pr-i Pr-i H O H GaEt Pr-i Pr-i H S H G3Et Pr-i Bu-n H O H GaEt Pr-i Bu-n H S H G3R1 R2 R3 R4 X M GnEt Bu-n me H O H GaEt Bu-n Me H S H G3Et Bu-n Et H O H GaEt Bu-n Et H S H G3Et Bu-n Pr-n H O H GaEt Bu-n Pr-n H S H G3Et Bu-n Pr-i H O H GaEt Bu-n Pr-i H S H G3Et Bu-n Bu-n H O H GaEt Bu-n Bu-n H S H G3Pr-n Me Me H O H GaPr-n Me Me h S H G3Pr-n Me Et H O H GaPr-n Me Et H S H G3Pr-n Me Pr-n H O H GaPr-n Me Pr-n H S H G3Pr-n Me Pr-i H O H GaPr-n Me Pr-i H S H G3Pr-n Me Bu-n H O H GaPr-n Me Bu-n H S H G3Pr-n Et Me H O H GaPr-n Et Me H S H G3Pr-n Et Et H O H GaPr-n Et Et H S H G3Pr-n Et Pr-n H O H GaPr-n Et Pr-n H S H G3Pr-n Et Pr-i H O H GaPr-n Et Pr-i H S H G3Pr-n Et Bu-n H O H GaPr-n Et Bu-n H S H G3Pr-n Pr-n Me H O H GaPr-n Pr-n Me H S H G3Pr-n Pr-n Et H O H GaPr-n Pr-n Et H S H G3Pr-n Pr-n Pr-n H O H GaPr-n Pr-n Pr-n H S H G3Pr-n Pr-n Pr-i H O H GaPr-n Pr-n Pr-i H S H G3Pr-n Pr-n Bu-n H O H GaPr-n Pr-n Bu-n H S H G3R1 R2 R3 R4 X M GnPr-n Pr-i Me H O H GaPr-n Pr-i Me H S H G3Pr-n Pr-i Et H O H GaPr-n Pr-i Et H S H G3Pr-n Pr-i Pr-n H O H GaPr-n Pr-i Pr-n H S H G3Pr-n Pr-i Pr-i H O H GaPr-n Pr-i Pr-i H S H G3Pr-n Pr-i Bu-n H O H GaPr-n Pr-i Bu-n H S H G3Pr-n Bu-n Me H O H GaPr-n Bu-n Me H S H G3Pr-n Bu-n Et H O H GaPr-n Bu-n Et H S H G3Pr-n Bu-n Pr-n H O H GaPr-n Bu-n Pr-n H S H G3Pr-n Bu-n Pr-i H O H GaPr-n Bu-n Pr-i H S H G3Pr-n Bu-n Bu-n H O H GaPr-n Bu-n Bu-n H S H G3Pr-i Me Me H O H GaPr-i Me Me H S H G3Pr-i Me Et H O H GaPr-i Me Et H S H G3Pr-i Me Pr-n H O H G3Pr-i Me Pr-n H S H G3Pr-i Me Pr-i H O H GaPr-i Me Pr-i H S H G3Pr-i Me Bu-n H O H GaPr-i Me Bu-n H S H G3Pr-i Et Me H O H GaPr-i Et Me H S H G3Pr-i Et Et H O H GaPr-i Et Et H S H G3Pr-i Et Pr-n H O H GaPr-i Et Pr-n H S H G3Pr-i Et Pr-i H O H GaPr-i Et Pr-i H S H G3Pr-i Et Bu-n H O H GaPr-i Et Bu-n H S H G3R1 R2 R3 R4 X M GnPr-i Pr-n Me H O H GaPr-i Pr-n Me H S H G3Pr-i Pr-n Et H O H GaPr-i Pr-n Et H S H G3Pr-i Pr-n Pr-n H O H GaPr-i Pr-n Pr-n H S H G3Pr-i Pr-n Pr-i H O H GaPr-i Pr-n Pr-i H S H G3Pr-i Pr-n Bu-n H O H GaPr-i Pr-n Bu-n H S H G3Pr-i Pr-i Me H O H GaPr-i Pr-i Me H S H G3Pr-i Pr-i Et H O H GaPr-i Pr-i Et H S H G3Pr-i Pr-i Pr-n H O H GaPr-i Pr-i Pr-n H S H G3Pr-i Pr-i Pr-i H O H GaPr-i Pr-i Pr-i H S H G3Pr-i Pr-i Bu-n H O H GaPr-i Pr-i Bu-n H S H G3Pr-i Bu-n Me H O H GaPr-i Bu-n Me H S H G3Pr-i Bu-n Et H O H GaPr-i Bu-n Et H S H G3Pr-i Bu-n Pr-n H O H GaPr-i Bu-n Pr-n H S H G3Pr-i Bu-n Pr-i H O H GaPr-i Bu-n Pr-i H S H G3Pr-i Bu-n Bu-n H O H GaPr-i Bu-n Bu-n H S H G3Bu-n Me Me H O H GaBu-n Me Me H S H G3Bu-n Me Et H O H GaBu-n Me Et H S H G3Bu-n Me Pr-n H O H GaBu-n Me Pr-n H S H G3Bu-n Me Pr-i H O H GaBu-n Me Pr-i H S H G3Bu-n Me Bu-n H O H GaBu-n Me Bu-n H S H G3R1 R2 R3 R4 X M GnBu-n Et Me H O H GaBu-n Et Me H S H G3Bu-n Et Et H O H GaBu-n Et Et H S H G3Bu-n Et Pr-n H O H GaBu-n Et Pr-n H S H G3Bu-n Et Pr-i H O H GaBu-n Et Pr-i H S H G3Bu-n Et Bu-n H O H GaBu-n Et Bu-n H S H G3Bu-n Pr-n Me H O H GaBu-n Pr-n Me H S H G3Bu-n Pr-n Et H O H GaBu-n Pr-n Et H S H G3Bu-n Pr-n Pr-n H O H GaBu-n Pr-n Pr-n H S H G3Bu-n Pr-n Pr-i H O H GaBu-n Pr-n Pr-i H S H G3Bu-n Pr-n Bu-n H O H GaBu-n Pr-n Bu-n H S H G3Bu-n Pr-i Me H O H GaBu-n Pr-i Me H S H G3Bu-n Pr-i Et H O H GaBu-n Pr-i Et H S H G3Bu-n Pr-i Pr-n H O H GaBu-n Pr-i Pr-n H S H G3Bu-n Pr-i Pr-i H O H GaBu-n Pr-i Pr-i H S H G3Bu-n Pr-i Bu-n H O H GaBu-n Pr-i Bu-n H S H G3Bu-n Bu-n Me H O H GaBu-n Bu-n Me H S H G3Bu-n Bu-n Et H O H GaBu-n Bu-n Et H S H G3Bu-n Bu-n Pr-n H O H GaBu-n Bu-n Pr-n H S H G3Bu-n Bu-n Pr-i H O H GaBu-n Bu-n Pr-i H S H G3Bu-n Bu-n Bu-n H O H GaBu-n Bu-n Bu-n H S H G3R1 R2 R3 R4 X M GnF H Me H O H GaCl H Me H O H GaBr H Me H O H GaI H Me H O H GaCH＝CH2 H Me H O H GaCH2CH＝CH2 H Me H O H GaC≡CH H Me H O H GaCH2C≡CH H Me H O H GaCH2F H Me H O H GaCHF2 H Me H O H GaCN H Me H O H GaNH2 H Me H O H GaNHCOMe H Me H O H GaCH2NH2 H Me H O H GaCH2NHCOMe H Me H O H GaCH2OCHF2 H Me H O H GaCF3 H Me H O H GaNO2 H Me H O H GbOMe H Me H O H GaOEt H Me H O H GaOPr-n H Me H O H GbSMe H Me H O H GaSEt H Me H O H GaSO2Me H Me H O H GaSO2Et H Me H O H GaCOMe H Me H O H GaCOEt H Me H O H GaCO2H H Me H O H GbCO2Me H Me H O H GaCO2Et H Me H O H GaCO2Pr-n H Me H O H GbCO2Bu-n H Me H O H GcCH2Cl H Me H O H GaCH2Br H Me H O H GbCH2I H Me H O H GbCH2CF3 H Me H O H GaCH2CN H Me H O H GaCH2OH H Me H O H GbCH2OMe H Me H O H GaCH2OEt H Me H O H GaR1 R2 R3 R4 X M GnCH2OPr-n H Me H O H GbCH2SMe H Me H O H GaCH2SEt H me H O H GaCH2SPr-n H Me H O H GbCH2SO2Me H Me H O H GaCH2SO2Et H Me H O H GaCH2COMe H Me H O H GaCH2COEt H Me H O H GaCH2COPr-n H Me H O H GbCH2CO2H H Me H O H GbCH2CO2Me H Me H O H GaCH2CO2Et H Me H O H GaCH2CO2Pr-n H Me H O H GbCH2OCH2CH＝CH2 H Me H O H GbCH2OCH2C≡CH H Me H O H GbCH＝CHCO2Me H Me H O H GaCH＝CHCO2Et H Me H O H GaCH＝CHCO2Pr-n H Me H O H GbCH＝CHCN H Me H O H GaPh H Me H O H GaCH2Ph H Me H O H GaOPh H Me H O H GaSPh H Me H O H GaSO2Ph H Me H O H GaCONHMe H Me H O H GaCONHEt H Me H O H GaCON(Me)2 H Me H O H GaCON(Et)2 H Me H O H GaF Me H H O H GaCl Me H H O H GaBr Me H H O H GaI Me H H O H GaCH＝CH2 Me H H O H GaCH2CH＝CH2 Me H H O H GaC≡CH Me H H O H GaCH2C≡CH Me H H O H GaCH2F Me H H O H GaCHF2 Me H H O H GaCN Me H H O H GaNH2 Me H H O H GaR1 R2 R3 R4 X M GnNHCOMe Me H H O H GaCH2NH2 Me H H O H GaCH2NHCOMe Me H H O H GaCH2OCHF2 Me H H O H GaCF3 Me H H O H GaNO2 Me H H O H GbOMe Me H H O H GaOEt Me H H O H GaOPr-n Me H H O H GbSMe Me H H O H GaSEt Me H H O H GaSO2Me Me H H O H GaSO2Et Me H H O H GaCOMe Me H H O H GaCOEt Me H H O H GaCO2H Me H H O H GbCO2Me Me H H O H GaCO2Et Me H H O H GaCO2Pr-n Me H H O H GbCO2Bu-n Me H H O H GcCH2Cl Me H H O H GaCH2Br Me H H O H GbCH2I Me H H O H GbCH2CF3 Me H H O H GaCH2CN Me H H O H GaCH2OH Me H H O H GbCH2OMe Me H H O H GaCH2OEt Me H H O H GaCH2OPr-n Me H H O H GbCH2SMe Me H H O H GaCH2SEt Me H H O H GaCH2SPr-n Me H H O H GbCH2SO2Me Me H H O H GaCH2SO2Et Me H H O H GaCH2COMe Me H H O H GaCH2COEt Me H H O H GaCH2COPr-n Me H H O H GbCH2CO2H Me H H O H GbCH2CO2Me Me H H O H GaCH2CO2Et Me H H O H GaR1 R2 R3 R4 X M GnCH2CO2Pr-n Me H H O H GbCH2OCH2CH＝CH2 Me H H O H GbCH2OCH2C≡CH Me H H O H GbCH＝CHCO2Me Me H H O H GaCH＝CHCO2Et Me H H O H GaCH＝CHCO2Pr-n Me H H O H GbCH＝CHCN Me H H O H GaPh Me H H O H GaCH2Ph Me H H O H GaOPh Me H H O H GaSPh Me H H O H GaSO2Ph Me H H O H GaCONHMe Me H H O H GaCONHEt Me H H O H GaCON(Me)2 Me H H O H GaCON(Et)2 Me H H O H GaF Et H H O H GaCl Et H H O H GaBr Et H H O H GaI Et H H O H GaCH＝CH2 Et H H O H GaCH2CH＝CH2 Et H H O H GaC≡CH Et H H O H GaCH2C≡CH Et H H O H GaCH2F Et H H O H GaCHF2 Et H H O H GaCN Et H H O H GaNH2 Et H H O H GaNHCOMe Et H H O H GaCH2NH2 Et H H O H GaCH2NHCOMe Et H H O H GaCH2OCHF2 Et H H O H GaCF3 Et H H O H GaNO2 Et H H O H GbOMe Et H H O H GaOEt Et H H O H GaOPr-n Et H H O H GbSMe Et H H O H GaSEt Et H H O H GaSO2Me Et H H O H GaR1 R2 R3 R4 X M GnSO2Et Et H H O H GaCOMe Et H H O H GaCOEt Et H H O H GaCO2H Et H H O H GbCO2Me Et H H O H GaCO2Et Et H H O H GaCO2Pr-n Et H H O H GbCO2Bu-n Et H H O H GcCH2Cl Et H H O H GaCH2Br Et H H O H GbCH2I Et H H O H GbCH2CF3 Et H H O H GaCH2CN Et H H O H GaCH2OH Et H H O H GbCH2OMe Et H H O H GaCH2OEt Et H H O H GaCH2OPr-n Et H H O H GbCH2SMe Et H H O H GaCH2SEt Et H H O H GaCH2SPr-n Et H H O H GbCH2SO2Me Et H H O H GaCH2SO2Et Et H H O H GaCH2COMe Et H H O H GaCH2COEt Et H H O H GaCH2COPr-n Et H H O H GbCH2CO2H Et H H O H GbCH2CO2Me Et H H O H GaCH2CO2Et Et H H O H GaCH2CO2Pr-n Et H H O H GbCH2OCH2CH＝CH2 Et H H O H GbCH2OCH2C≡CH Et H H O H GbCH＝CHCO2Me Et H H O H GaCH＝CHCO2Et Et H H O H GaCH＝CHCO2Pr-n Et H H O H GbCH＝CHCN Et H H O H GaPh Et H H O H GaCH2Ph Et H H O H GaOPh Et H H O H GaSPh Et H H O H GaSO2Ph Et H H O H GaR1 R2 R3 R4 X M GnCONHMe Et H H O H GaCONHEt Et H H O H GaCON(Me)2 Et H H O H GaCON(Et)2 Et H H O H GaF H Pr-n H O H GaCl H Pr-n H O H GaBr H Pr-n H O H GaI H Pr-n H O H GaCH＝CH2 H Pr-n H O H GaCH2CH＝CH2 H Pr-n H O H GaC≡CH H Pr-n H O H GaCH2C≡CH H Pr-n H O H GaCH2F H Pr-n H O H GaCHF2 H Pr-n H O H GaCN H Pr-n H O H GaNH2 H Pr-n H O H GaNHCOMe H Pr-n H O H GaCH2NH2 H Pr-n H O H GaCH2NHCOMe H Pr-n H O H GaCH2OCHF2 H Pr-n H O H GaCF3 H Pr-n H O H GaNO2 H Pr-n H O H GbOMe H Pr-n H O H GaOEt H Pr-n H O H GaOPr-n H Pr-n H O H GbSMe H Pr-n H O H GaSEt H Pr-n H O H GaSO2Me H Pr-n H O H GaSO2Et H Pr-n H O H GaCOMe H Pr-n H O H GaCOEt H Pr-n H O H GaCO2H H Pr-n H O H GbCO2Me H Pr-n H O H GaCO2Et H Pr-n H O H GaCO2Pr-n H Pr-n H O H GbCO2Bu-n H Pr-n H O H GcCH2Cl H Pr-n H O H GaCH2Br H Pr-n H O H GbCH2I H Pr-n H O H GbCH2CF3 H Pr-n H O H GaR1 R2 R3 R4 X M GnCH2CN H Pr-n H O H GaCH2OH H Pr-n H O H GbCH2OMe H Pr-n H O H GaCH2OEt H Pr-n H O H GaCH2OPr-n H Pr-n H O H GbCH2SMe H Pr-n H O H GaCH2SEt H Pr-n H O H GaCH2SPr-n H Pr-n H O H GbCH2SO2Me H Pr-n H O H GaCH2SO2Et H Pr-n H O H GaCH2COMe H Pr-n H O H GaCH2COEt H Pr-n H O H GaCH2COPr-n H Pr-n H O H GbCH2CO2H H Pr-n H O H GbCH2CO2Me H Pr-n H O H GaCH2CO2Et H Pr-n H O H GaCH2CO2Pr-n H Pr-n H O H GbCH2OCH2CH＝CH2 H Pr-n H O H GbCH2OCH2C≡CH H Pr-n H O H GbCH＝CHCO2Me H Pr-n H O H GaCH＝CHCO2Et H Pr-n H O H GaCH＝CHCO2Pr-n H Pr-n H O H GbCH＝CHCN H Pr-n H O H GaPh H Pr-n H O H GaCH2Ph H Pr-n H O H GaOPh H Pr-n H O H GaSPh H Pr-n H O H GaSO2Ph H Pr-n H O H GaCONHMe H Pr-n H O H GaCONHEt H Pr-n H O H GaCON(Me)2 H Pr-n H O H GaCON(Et)2 H Pr-n H O H GaF H Cl H O H GaCl H Cl H O H GaBr H Cl H O H GaI H Cl H O H GaCH＝CH2 H Cl H O H GaCH2CH＝CH2 H Cl H O H GaC≡CH H Cl H O H GaCH2C≡CH H Cl H O H GaR1 R2 R3 R4 X M GnCHl2F H Cl H O H GaCHF2 H Cl H O H GaCN H Cl H O H GaNH2 H Cl H O H GaNHCOMe H Cl H O H GaCH2NH2 H Cl H O H GaCH2NHCOMe H Cl H O H GaCH2OCHF2 H Cl H O H GaCF3 H Cl H O H GaNO2 H Cl H O H GbOMe H Cl H O H GaOEt H Cl H O H GaOPr-n H Cl H O H GbSMe H Cl H O H GaSEt H Cl H O H GaSO2Me H Cl H O H GaSO2Et H Cl H O H GaCOMe H Cl H O H GaCOEt H Cl H O H GaCO2H H Cl H O H GbCO2Me H Cl H O H GaCO2Et H Cl H O H GaCO2Pr-n H Cl H O H GbCO2Bu-n H Cl H O H GcCH2Cl H Cl H O H GaCH2Br H Cl H O H GbCH2I H Cl H O H GbCH2CF3 H Cl H O H GaCH2CN H Cl H O H GaCH2OH H Cl H O H GbCH2OMe H Cl H O H GaCH2OEt H Cl H O H GaCH2OPr-n H Cl H O H GbCH2SMe H Cl H O H GaCH2SEt H Cl H O H GaCH2SPr-n H Cl H O H GbCH2SO2Me H Cl H O H GaCH2SO2Et H Cl H O H GaCH2COMe H Cl H O H GaCH2COEt H Cl H O H GaR1 R2 R3 R4 X M GnCH2COPr-n H Cl H O H GbCH2CO2H H Cl H O H GbCH2CO2Me H Cl H O H GaCH2CO2Et H Cl H O H GaCH2CO2Pr-n H Cl H O H GbCH2OCH2CH＝CH2 H Cl H O H GbCH2OCH2C≡CH H Cl H O H GbCH＝CHCO2Me H Cl H O H GaCH＝CHCO2Et H Cl H O H GaCH＝CHCO2Pr-n H Cl H O H GbCH＝CHCN H Cl H O H GaPh H Cl H O H GaCH2Ph H Cl H O H GaOPh H Cl H O H GaSPh H Cl H O H GaSO2Ph H Cl H O H GaCONHMe H Cl H O H GaCONHEt H Cl H O H GaCON(Me)2 H Cl H O H GaCON(Et)2 H Cl H O H GaF H NO2 H O H GaCl H NO2 H O H GaBr H NO2 H O H GaI H NO2 H O H GaCH＝CH2 H NO2 H O H GaCH2CH＝CH2 H NO2 H O H GaC≡CH H NO2 H O H GaCH2C≡CH H NO2 H O H GaCH2F H NO2 H O H GaCHF2 H NO2 H O H GaCN H NO2 H O H GaNH2 H NO2 H O H GaNHCOMe H NO2 H O H GaCH2NH2 H NO2 H O H GaCH2NHCOMe H NO2 H O H GaCH2OCHF2 H NO2 H O H GaCF3 H NO2 H O H GaNO2 H NO2 H O H GbOMe H NO2 H O H GaOEt H NO2 H O H GaR1 R2 R3 R4 X M GnOPr-n H NO2 H O H GbSMe H NO2 H O H GaSEt H NO2 H O H GaSO2Me H NO2 H O H GaSO2Et H NO2 H O H GaCOMe H NO2 H O H GaCOEt H NO2 H O H GaCO2H H NO2 H O H GbCO2Me H NO2 H O H GaCO2Et H NO2 H O H GaCO2Pr-n H NO2 H O H GbCO2Bu-n H NO2 H O H GcCH2Cl H NO2 H O H GaCH2Br H NO2 H O H GbCH2I H NO2 H O H GbCH2CF3 H NO2 H O H GaCH2CN H NO2 H O H GaCH2OH H NO2 H O H GbCH2OMe H NO2 H O H GaCH2OEt H NO2 H O H GaCH2OPr-n H NO2 H O H GbCH2SMe H NO2 H O H GaCH2SEt H NO2 H O H GaCH2SPr-n H NO2 H O H GbCH2SO2Me H NO2 H O H GaCH2SO2Et H NO2 H O H GaCH2COMe H NO2 H O H GaCH2COEt H NO2 H O H GaCH2COPr-n H NO2 H O H GbCH2CO2H H NO2 H O H GbCH2CO2Me H NO2 H O H GaCH2CO2Et H NO2 H O H GaCH2CO2Pr-n H NO2 H O H GbCH2OCH2CH＝CH2 H NO2 H O H GbCH2OCH2C≡CH H NO2 H O H GbCH＝CHCO2Me H NO2 H O H GaCH＝CHCO2Et H NO2 H O H GaCH＝CHCO2Pr-n H NO2 H O H GbCH＝CHCN H NO2 H O H GaPh H NO2 H O H GaR1 R2 R3 R4 X M GnCH2Ph H NO2 H O H GaOPh H NO2 H O H GaSPh H NO2 H O H GaSO2Ph H NO2 H O H GaCONHMe H NO2 H O H GaCONHEt H NO2 H O H GaCON(Me)2 H NO2 H O H GaCON(Et)2 H NO2 H O H GaF H CF3 H O H GaCl H CF3 H O H GaBr H CF3 H O H GaI H CF3 H O H GaCH＝CH2 H CF3 H O H GaCH2CH＝CH2 H CF3 H O H GaC≡CH H CF3 H O H GaCH2C≡CH H CF3 H O H GaCH2F H CF3 H O H GaCHF2 H CF3 H O H GaCN H CF3 H O H GaNH2 H CF3 H O H GaNHCOMe H CF3 H O H GaCH2NH2 H CF3 H O H GaCH2NHCOMe H CF3 H O H GaCH2OCHF2 H CF3 H O H GaCF3 H CF3 H O H GaNO2 H CF3 H O H GbOMe H CF3 H O H GaOEt H CF3 H O H GaOPr-n H CF3 H O H GbSMe H CF3 H O H GaSEt H CF3 H O H GaSO2Me H CF3 H O H GaSO2Et H CF3 H O H GaCOMe H CF3 H O H GaCOEt H CF3 H O H GaCO2H H CF3 H O H GbCO2Me H CF3 H O H GaCO2Et H CF3 H O H GaCO2Pr-n H CF3 H O H GbCO2Bu-n H CF3 H O H GcR1 R2 R3 R4 X M GnCH2Cl H CF3 H O H GaCH2Br H CF3 H O H GbCH2I H CF3 H O H GbCH2CF3 H CF3 H O H GaCH2CN H CF3 H O H GaCH2OH H CF3 H O H GbCH2OMe H CF3 H O H GaCH2OEt H CF3 H O H GaCH2OPr-n H CF3 H O H GbCH2SMe H CF3 H O H GaCH2SEt H CF3 H O H GaCH2SPr-n H CF3 H O H GbCH2SO2Me H CF3 H O H GaCH2SO2Et H CF3 H O H GaCH2COMe H CF3 H O H GaCH2COEt H CF3 H O H GaCH2COPr-n H CF3 H O H GbCH2CO2H H CF3 H O H GbCH2CO2Me H CF3 H O H GaCH2CO2Et H CF3 H O H GaCH2CO2Pr-n H CF3 H O H GbCH2OCH2CH＝CH2 H CF3 H O H GbCH2OCH2C≡CH H CF3 H O H GbCH＝CHCO2Me H CF3 H O H GaCH＝CHCO2Et H CF3 H O H GaCH＝CHCO2Pr-n H CF3 H O H GbCH＝CHCN H CF3 H O H GaPh H CF3 H O H GaCH2Ph H CF3 H O H GaOPh H CF3 H O H GaSPh H CF3 H O H GaSO2Ph H CF3 H O H GaCONHMe H CF3 H O H GaCONHEt H CF3 H O H GaCON(Me)2 H CF3 H O H GaCON(Et)2 H CF3 H O H GaF H OMe H O H GaCl H OMe H O H GaBr H OMe H O H GaI H OMe H O H GaR1 R2 R3 R4 X M GnCH＝CH2 H OMe H O H GaCH2CH＝CH2 H OMe H O H GaC≡CH H OMe H O H GaCH2C≡CH H OMe H O H GaCH2F H OMe H O H GaCHF2 H OMe H O H GaCN H OMe H O H GaNH2 H OMe H O H GaNHCOMe H OMe H O H GaCH2NH2 H OMe H O H GaCH2NHCOMe H OMe H O H GaCH2OCHF2 H OMe H O H GaCF3 H OMe H O H GaNO2 H OMe H O H GbOMe H OMe H O H GaOEt H OMe H O H GaOPr-n H OMe H O H GbSMe H OMe H O H GaSEt H OMe H O H GaSO2Me H OMe H O H GaSO2Et H OMe H O H GaCOMe H OMe H O H GaCOEt H OMe H O H GaCO2H H OMe H O H GbCO2Me H OMe H O H GaCO2Et H OMe H O H GaCO2Pr-n H OMe H O H GbCO2Bu-n H OMe H O H GcCH2Cl H OMe H O H GaCH2Br H OMe H O H GbCH2I H OMe H O H GbCH2CF3 H OMe H O H GaCH2CN H OMe H O H GaCH2OH H OMe H O H GbCH2OMe H OMe H O H GaCH2OEt H OMe H O H GaCH2OPr-n H OMe H O H GbCH2SMe H OMe H O H GaCH2SEt H OMe H O H GaCH2SPr-n H OMe H O H GbR1 R2 R3 R4 X M GnCH2SO2Me H OMe H O H GaCH2SO2Et H OMe H O H GaCH2COMe H OMe H O H GaCH2COEt H OMe H O H GaCH2COPr-n H OMe H O H GbCH2CO2H H OMe H O H GbCH2CO2Me H OMe H O H GaCH2CO2Et H OMe H O H GaCH2CO2Pr-n H OMe H O H GbCH2OCH2CH＝CH2H OMe H O H GbCH2OCH2C≡CH H OMe H O H GbCH＝CHCO2Me H OMe H O H GaCH＝CHCO2Et H OMe H O H GaCH＝CHCO2Pr-n H OMe H O H GbCH＝CHCN H OMe H O H GaPh H OMe H O H GaCH2Ph H OMe H O H GaOPh H OMe H O H GaSPh H OMe H O H GaSO2Ph H OMe H O H GaCONHMe H OMe H O H GaCONHEt H OMe H O H GaCON(Me)2 H OMe H O H GaCON(Et)2 H OMe H O H GaF H SMe H O H GaCl H SMe H O H GaBr H SMe H O H GaI H SMe H O H GaCH＝CH2 H SMe H O H GaCH2CH＝CH2 H SMe H O H GaC≡CH H SMe H O H GaCH2C≡CH H SMe H O H GaCH2P H SMe H O H GaCHF2 H SMe H O H GaCN H SMe H O H GaNH2 H SMe H O H GaNHCOMe H SMe H O H GaCH2NH2 H SMe H O H GaCH2NHCOHe H SMe H O H GaCH2OCHF2 H SMe H O H GaR1 R2 R3 R4 X M GnCF3 H SMe H O H GaNO2 H SMe H O H GbOMe H SMe H O H GaOEt H SMe H O H GaOPr-n H SMe H O H GbSMe H SMe H O H GaSEt H SMe H O H GaSO2Me H SMe H O H GaSO2Et H SMe H O H GaCOMe H SMe H O H GaCOEt H SMe H O H GaCO2H H SMe H O H GbCO2Me H SMe H O H GaCO2Et H SMe H O H GaCO2Pr-n H SMe H O H GbCO2Bu-n H SMe H O H GcCH2Cl H SMe H O H GaCH2Br H SMe H O H GbCH2I H SMe H O H GbCH2CF3 H SMe H O H GaCH2CN H SMe H O H GaCH2OH H SMe H O H GbCH2OMe H SMe H O H GaCH2OEt H SMe H O H GaCH2OPr-n H SMe H O H GbCH2SMe H SMe H O H GaCH2SEt H SMe H O H GaCH2SPr-n H SMe H O H GbCH2SO2Me H SMe H O H GaCH2SO2Et H SMe H O H GaCH2COMe H SMe H O H GaCH2COEt H SMe H O H GaCH2COPr-n H SMe H O H GbCH2CO2H H SMe H O H GbCH2CO2Me H SMe H O H GaCH2CO2Et H SMe H O H GaCH2CO2Pr-n H SMe H O H GbCH2OCH2CH＝CH2H SMe H O H GbCH2OCH2C≡CH H SMe H O H GbCH＝CHCO2Me H SMe H O H GaR1 R2 R3 R4 X M GnCH＝CHCO2Et H SMe H O H GaCH＝CHCO2Pr-n H SMe H O H GbCH＝CHCN H SMe H O H GaPh H SMe H O H GaCH2Ph H SMe H O H GaOPh H SMe H O H GaSPh H SMe H O H GaSO2Ph H SMe H O H GaCONHMe H SMe H O H GaCONHEt H SMe H O H GaCON(Me)2 H SMe H O H GaCON(Et)2 H SMe H O H GaF H SO2Me H O H GaCl H SO2Me H O H GaBr H SO2Me H O H GaI H SO2Me H O H GaCH＝CH2 H SO2Me H O H GaCH2CH＝CH2 H SO2Me H O H GaC≡CH H SO2Me H O H GaCH2C≡CH H SO2Me H O H GaCH2F H SO2Me H O H GaCHF2 H SO2Me H O H GaCN H SO2Me H O H GaNH2 H SO2Me H O H GaNHCOMe H SO2Me H O H GaCH2NH2 H SO2Me H O H GaCH2NHOMe H SO2Me H O H GaCH2OCHF2 H SO2Me H O H GaCF3 H SO2Me H O H GaNO2 H SO2Me H O H GbOMe H SO2Me H O H GaOEt H SO2Me H O H GaOPr-n H SO2Me H O H GbSMe H SO2Me H O H GaSEt H SO2Me H O H GaSO2Me H SO2Me H O H GaSO2Et H SO2Me H O H GaCOMe H SO2Me H O H GaCOEt H SO2Me H O H GaCO2H H SO2Me H O H GbR1 R2 R3 R4 X M GnCO2Me H SO2Me H O H GaCO2Et H SO2Me H O H GaCO2Pr-n H SO2Me H O H GbCO2Bu-n H SO2Me H O H GcCH2Cl H SO2Me H O H GaCH2Br H SO2Me H O H GbCH2I H SO2Me H O H GbCH2CF3 H SO2Me H O H GaCH2CNH H SO2Me H O H GaCH2OH H SO2Me H O H GbCH2OMe H SO2Me H O H GaCH2OEt H SO2Me H O H GaCH2OPr-n H SO2Me H O H GbCH2SMe H SO2Me H O H GaCH2SEt H SO2Me H O H GaCH2SPr-n H SO2Me H O H GbCH2SO2Me H SO2Me H O H GaCH2SO2Et H SO2Me H O H GaCH2COMe H SO2Me H O H GaCH2COEt H SO2Me H O H GaCH2COPr-n H SO2Me H O H GbCH2CO2H H SO2Me H O H GbCH2CO2Me H SO2Me H O H GaCH2COHEt H SO2Me H O H GaCH2CO2PH-n H SO2Me H O H GbCH2OCH2EH＝CH2 H SO2Me H O H GbCH2OCH2E≡CH H SO2Me H O H GbCH＝CHCO2Me H SO2Me H O H GaCH＝CHCO2Et H SO2Me H O H GaCH＝CHCO2Pr-n H SO2Me H O H GbCH＝CHCN H SO2Me H O H GaPh H SO2Me H O H GaCH2Ph H SO2Me H O H GaOPh H SO2Me H O H GaSPh H SO2Me H O H GaSO2Ph H SO2Me H O H GaCONHMe H SO2Me H O H GaCONHEt H SO2Me H O H GaCON(Me)2 H SO2Me H O H GaCON(Et)2 H SO2Me H O H GaR1 R2 R3 R4 X M GnF H COMe H O H GaCl H COMe H O H GaBr H COMe H O H GaI H COMe H O H GaCH＝CH2 H COMe H O H GaCH2CH＝CH2H COMe H O H GaC≡CH H COMe H O H GaCH2C＝CH H COMe H O H GaCM2F H COMe H O H GaCHF2 H COMe H O H GaCN H COMe H O H GaNH2 H COMe H O H GaNHCOMe H COMe H O H GaCH2NH2 H COMe H O H GaCH2NHCOMe H COMe H O H GaCH2OCHF2 H COMe H O H GaCF3 H COMe H O H GaNO2 H COMe H O H GbOMe H COMe H O H GaOEt H OOMe H O H GaOPr-n H COMe H O H GbSMe H COMe H O H GaSEt H COMe H O H GaSO2Me H COMe H O H GaSO2Et H COMe H O H GaCOMe H COMe H O H GaCOEt H COMe H O H GaCO2H H COMe H O H GbCO2Me H COMe H O H GaCO2Et H COMe H O H GaCO2Pr-n H COMe H O H GbCO2Bu-n H COMe H O H GcCH2Cl H COMe H O H GaCH2Bn H COMe H O H GbCH2I H COMe H O H GbCH2CF3 H COMe H O H GaCH2CN H COMe H O H GaCH2ON H COMe H O H GbCH2OMe H COMe H O H GaCH2OEt H COMe H O H GaR1 R2 R3 R4 X M GnCH2OPr-n H COMe H O H GbCH2SMe H COMe H O H GaCH2SEt H COMe H O H GaCH2SPr-n H COMe H O H GbCH2SO2Me H COMe H O H GaCH2SO2Et H COMe H O H GaCH2COMe H COMe H O H GaCH2COEt H COMe H O H GaCH2COPr-n H COMe H O H GbCH2CO2H H COMe H O H GbCH2CO2Me H COMe H O H GaCH2CO2Et H COMe H O H GaCH2CO2Pr-n H COMe H O H GbCH2OCH2CH＝CH2H COMe H O H GbCH2OCH2C≡CH H COMe H O H GbCH＝CHCO2Me H COMe H O H GaCH＝CHCO2Et H COMe H O H GaCH＝CHCO2Pr H COMe H O H GbCH＝CHCN H COMe H O H GaPh H COMe H O H GaCH2Ph H COMe H O H GaOPh H COMe H O H GaSPh H COMe H O H GaSO2Pe H COMe H O H GaCONHMe H COMe H O H GaCONHPt H COMe H O H GaCON(Me)2 H COMe H O H GaCON(Et)2 H COMe H O H GaF H CO2Me H O H GaCl H CO2Me H O H GaBr H CO2Me H O H GaI H CO2Me H O H GaCH＝CH2 H CO2Me H O H GaCH2CH＝CH2 H CO2Me H O H GaC≡CH H CO2Me H O H GaCH2C＝CH H CO2Me H O H GaCH2F H CO2Me H O H GaCHF2 H CO2Me H O H GaCN H CO2Me H O H GaNH2 H CO2Me H O H GaR1 R2 R3 R4 X M GnNHCOMe H CO2Me H O H GaCH2NH2 H CO2Me H O H GaCH2NHCOMe H CO2Me H O H GaCH2OCHF2 H CO2Me H O H GaCF3 H CO2Me H O H GaNO2 H CO2Me H O H GbOMe H CO2Me H O H GaOEt H CO2Me H O H GaOPr-n H CO2Me H O H GbSMe H CO2Me H O H GaSEt H CO2Me H O H GaSO2Me H CO2Me H O H GaSO2Et H CO2Me H O H GaCOMe H CO2Me H O H GaCOEt H CO2Me H O H GaCO2H H CO2Me H O H GbCO2Me H CO2Me H O H GaCO2Et H CO2Me H O H GaCO2Pr-n H CO2Me H O H GbCO2Bu-n H CO2Me H O H GcCH2Cl H CO2Me H O H GaCH2Br H CO2Me H O H GbCH2I H CO2Me H O H GbCH2CF3 H CO2Me H O H GaCH2CN H CO2Me H O H GaCH2OH H CO2Me H O H GbCH2OMe H CO2Me H O H GaCH2OEt H CO2Me H O H GaCH2OPr-n H CO2Me H O H GbCH2SMe H CO2Me H O H GaCH2SEt H CO2Me H O H GaCH2SPr-n H CO2Me H O H GbCH2SO2Me H CO2Me H O H GaCH2SO2Et H CO2Me H O H GaCH2COMe H CO2Me H O H GaCH2COEt H CO2Me H O H GaCH2COPr-n H CO2Me H O H GbCH2CO2H H CO2Me H O H GbCH2CO2Me H CO2Me H O H GaCH2CO2Et H CO2Me H O H GaR1 R2 R3 R4 X M GnCH2CO2Pr-n H CO2Me H O H GbCH2OCH2CH＝CH2H CO2Me H O H GbCH2OCH2C≡CH H CO2Me H O H GbCH＝CHCO2Me H CO2Me H O H GaCH＝CHCO2Et H CO2Me H O H GaCH＝CHCO2Pr-n H CO2Me H O H GbCH＝CHCN H CO2Me H O H GaPh H CO2Me H O H GaCH2Ph H CO2Me H O H GaOPh H CO2Me H O H GaSPh H CO2Me H O H GaSO2Ph H CO2Me H O H GaCONHMe H CO2Me H O H GaCONHEt H CO2Me H O H GaCON(Me)2 H CO2Me H O H GaCON(Et)2 H CO2Me H O H GaF H CO2H H O H GaCl H CO2H H O H GaBr H CO2H H O H GaI H CO2H H O H GaCH＝CH2 H CO2H H O H GaCH2CH＝CH2 H CO2H H O H GaC≡CH H CO2H H O H GaCH2C≡CH H CO2H H O H GaCH2F H CO2H H O H GaCHF2 H CO2H H O H GaCN H CO2H H O H GaNH2 H CO2H H O H GaNHCOMe H CO2H H O H GaCH2NH2 H CO2H H O H GaCH2NHCOMe H CO2H H O H GaCH2OCHF2 H CO2H H O H GaCF3 H CO2H H O H GaNO2 H CO2H H O H GbOMe H CO2H H O H GaOEt H CO2H H O H GaOPr-n H CO2H H O H GbSMe H CO2H H O H GaSEt H CO2H H O H GaSO2Me H CO2H H O H GaR1 R2 R3 R4 X M GnSO2Et H CO2H H O H GaCOMe H CO2H H O H GaCOEt H CO2H H O H GaCO2H H CO2H H O H GbCO2Me H CO2H H O H GaCO2Et H CO2H H O H GaCO2Pr-n H CO2H H O H GbCO2Bu-n H CO2H H O H GcCH2Cl H CO2H H O H GaCH2Br H CO2H H O H GbCH2I H CO2H H O H GbCH2CF3 H CO2H H O H GaCH2CN H CO2H H O H GaCH2OH H CO2H H O H GbCH2OMe H CO2H H O H GaCH2OEt H CO2H H O H GaCH2OPr-n H CO2H H O H GbCH2SMe H CO2H H O H GaCH2SEt H CO2H H O H GaCH2SPr-n H CO2H H O H GbCH2SO2Me H CO2H H O H GaCH2SO2Et H CO2H H O H GaCH2COMe H CO2H H O H GaCH2COEt H CO2H H O H GaCH2COPr-n H CO2H H O H GbCH2CO2H H CO2H H O H GbCH2CO2Me H CO2H H O H GaCH2CO2Et H CO2H H O H GaCH2CO2Pr-n H CO2H H O H GbCH2OCH2CH＝CH2H CO2H H O H GbCH2OCH2C≡CH H CO2H H O H GbCH＝CHCO2Me H CO2H H O H GaCH＝CHCO2Et H CO2H H O H GaCH＝CHCO2Pr-n H CO2H H O H GbCH＝CHCN H CO2H H O H GaPh H CO2H H O H GaCH2Ph H CO2H H O H GaOPh H CO2H H O H GaSPh H CO2H H O H GaSO2Ph H CO2H H O H GaR1 R2 R3 R4 X M GnCONHMe H CO2H H O H GaCONHEt H CO2H H O H GaCON(Me)2 H CO2H H O H GaCON(Et)2 H CO2H H O H GaF H CH2F H O H GaCl H CH2F H O H GaBr H CH2F H O H GaI H CH2F H O H GaCH＝CH2 H CH2F H O H GaCH2CH＝CH2H CH2F H O H GaC≡CH H CH2F H O H GaCH2C≡CH H CH2F H O H GaCH2F H CH2F H O H GaCHF2 H CH2F H O H GaCN H CH2F H O H GaNH2 H CH2F H O H GaNHCOMe H CH2F H O H GaCH2NH2 H CH2F H O H GaCH2NHCOMe H CH2F H O H GaCH2OCHF2 H CH2F H O H GaCF3 H CH2F H O H GaNO2 H CH2F H O H GbOMe H CH2F H O H GaOEt H CH2F H O H GaOPr-n H CH2F H O H GbSMe H CH2F H O H GaSEt H CH2F H O H GaSO2Me H CH2F H O H GaSO2Et H CH2F H O H GaCOMe H CH2F H O H GaCOEt H CH2F H O H GaCO2H H CH2F H O H GbCO2Me H CH2F H O H GaCO2Et H CH2F H O H GaCO2Pr-n H CH2F H O H GbCO2Bu-n H CH2F H O H GcCH2Cl H CH2F H O H GaCH2Br H CH2F H O H GbCH2I H CH2F H O H GbCH2CF3 H CH2F H O H GaR1 R2 R3 R4 X M GnCH2CN H CH2F H O H GaCH2OH H CH2F H O H GbCH2OMe H CH2F H O H GaCH2OEt H CH2F H O H GaCH2OPr-n H CH2F H O H GbCH2SMe H CH2F H O H GaCH2SEt H CH2F H O H GaCH2SPr-n H CH2F H O H GbCH2SO2Me H CH2F H O H GaCH2SO2Et H CH2F H O H GaCH2COMe H CH2F H O H GaCH2COEt H CH2F H O H GaCH2COPr-n H CH2F H O H GbCH2CO2H H CH2F H O H GbCH2CO2Me H CH2F H O H GaCH2CO2Et H CH2F H O H GaCH2CO2Pr-n H CH2F H O H GbCH2OCH2CH＝CH2 H CH2F H O H GbCH2OCH2C≡CH H CH2F H O H GbCH＝CHCO2Me H CH2F H O H GaCH＝CHCO2Et H CH2F H O H GaCH＝CHCO2Pr-n H CH2F H O H GbCH＝CHCN H CH2F H O H GaPhH H CH2F H O H GaCH2Ph H CH2F H O H GaOPh H CH2F H O H GaSPhH H CH2F H O H GaSO2Ph H CH2F H O H GaCONHMe H CH2F H O H GaCONHEt H CH2F H O H GaCON(Me)2 H CH2F H O H GaCON(Et)2 H CH2F H O H GaF H CH2Cl H O H GaCl H CH2Cl H O H GaBr H CH2Cl H O H GaI H CH2Cl H O H GaCH＝CH2 H CH2Cl H O H GaCH2OH＝CH2 H CH2Cl H O H GaC≡CH H CH2Cl H O H GaCH2C≡CH H CH2Cl H O H Ga
R1 R2 R3 R4 X M Gn
CH2F H CH2Cl H O H Ga
CHF2 H CH2Cl H O H Ga
CN H CH2Cl H O H Ga
NH2 H CH2Cl H O H Ga
NHCOMe H CH2Cl H O H Ga
CH2NH2 H CH2Cl H O H Ga
CH2NHCOMe H CH2Cl H O H Ga
CH2OCHF2 H CH2Cl H O H Ga
CF3 H CH2Cl H O H Ga
NO2 H CH2Cl H O H Gb
OMe H CH2Cl H O H Ga
OEt H CH2Cl H O H Ga
OPr-n H CH2Cl H O H Gb
SMe H CH2Cl H O H Ga
SEt H CH2Cl H O H Ga
SO2Me H CH2Cl H O H Ga
SO2Et H CH2Cl H O H Ga
COMe H CH2Cl H O H Ga
COEt H CH2Cl H O H Ga
CO2H H CH2Cl H O H Gb
CO2Me H CH2Cl H O H Ga
CO2Et H CH2Cl H O H Ga
CO2Pr-n H CH2Cl H O H Gb
CO2Bu-n H CH2Cl H O H Gc
CH2Cl H CH2Cl H O H Ga
CH2Br H CH2Cl H O H Gb
CH2I H CH2Cl H O H Gb
CH2CF3 H CH2Cl H O H Ga
CH2CN H CH2Cl H O H Ga
CH2OH H CH2Cl H O H Gb
CH2OMe H CH2Cl H O H Ga
CH2OEt H CH2Cl H O H Ga
CH2OPr-n H CH2Cl H O H Gb
CH2SMe H CH2Cl H O H Ga
CH2SEt H CH2Cl H O H Ga
CH2SPr-n H CH2Cl H O H Gb
CH2SO2Me H CH2Cl H O H Ga
CH2SO2Et H CH2Cl H O H Ga
CH2COMe H CH2Cl H O H Ga
CH2COEt H CH2Cl H O H Ga
R1 R2 R3 R4 X M Gn
CH2COPr-n H CH2Cl H O H Gb
CH2CO2H H CH2Cl H O H Gb
CH2CO2Me H CH2Cl H O H Ga
CH2CO2Et H CH2Cl H O H Ga
CH2CO2Pr-n H CH2Cl H O H Gb
CH2OCH2CH＝CH2 H CH2Cl H O H Gb
CH2OCH2C≡CH H CH2Cl H O H Gb
CH＝CHCO2Me H CH2Cl H O H Ga
CH＝CHCO2Et H CH2Cl H O H Ga
CH＝CHCO2Pr-n H CH2Cl H O H Gb
CH＝CHCN H CH2Cl H O H Ga
Ph H CH2Cl H O H Ga
CH2Ph H CH2Cl H O H Ga
OPh H CH2Cl H O H Ga
SPh H CH2Cl H O H Ga
SO2Ph H CH2Cl H O H Ga
CONHMe H CH2Cl H O H Ga
CONHEt H CH2Cl H O H Ga
CON(Me)2 H CH2Cl H O H Ga
CON(Et)2 H CH2Cl H O H Ga
F H CH2OMe H O H Ga
Cl H CH2OMe H O H Ga
Br H CH2OMe H O H Ga
I H CH2OMe H O H Ga
CH＝CH2 H CH2OMe H O H Ga
CH2CH＝CH2 H CH2OMe H O H Ga
C≡CH H CH2OMe H O H Ga
CH2C≡CH H CH2OMe H O H Ga
CH2F H CH2OMe H O H Ga
CHF2 H CH2OMe H O H Ga
CN H CH2OMe H O H Ga
NH2 H CH2OMe H O H Ga
NHCOMe H CH2OMe H O H Ga
CH2NH2 H CH2OMe H O H Ga
CH2NHCOMe H CH2OMe H O H Ga
CH2OCHF2 H CH2OMe H O H Ga
CF3 H CH2OMe H O H Ga
NO2 H CH2OMe H O H Gb
OMe H CH2OMe H O H Ga
OEt H CH2OMe H O H Ga
R1 R2 R3 R4 X M Gn
OPr-n H CH2OMe H O H Gb
SMe H CH2OMe H O H Ga
SEt H CH2OMe H O H Ga
SO2Me H CH2OMe H O H Ga
SO2Et H CH2OMe H O H Ga
COMe H CH2OMe H O H Ga
COEt H CH2OMe H O H Ga
CO2H H CH2OMe H O H Gb
CO2Me H CH2OMe H O H Ga
CO2Et H CH2OMe H O H Ga
CO2Pr-n H CH2OMe H O H Gb
CO2Bu-n H CH2OMe H O H Gc
CH2Cl H CH2OMe H O H Ga
CH2Br H CH2OMe H O H Gb
CH2I H CH2OMe H O H Gb
CH2CF3 H CH2OMe H O H Ga
CH2CN H CH2OMe H O H Ga
CH2OH H CH2OMe H O H Gb
CH2OMe H CH2OMe H O H Ga
CH2OEt H CH2OMe H O H Ga
CH2OPr-h H CH2OMe H O H Gb
CH2SMe H CH2OMe H O H Ga
CH2SEt H CH2OMe H O H Ga
CH2SPr-n H CH2OMe H O H Gb
CH2SO2Me H CH2OMe H O H Ga
CH2SO2Et H CH2OMe H O H Ga
CH2COMe H CH2OMe H O H Ga
CH2COEt H CH2OMe H O H Ga
CH2COPr-n H CH2OMe H O H Gb
CH2CO2H H CH2OMe H O H Gb
CH2CO2Me H CH2OMe H O H Ga
CH2CO2Et H CH2OMe H O H Ga
CH2CO2Pr-n H CH2OMe H O H Gb
CH2OCh2CH＝CH2 H CH2OMe H O H Gb
CH2OCH2C≡CH H CH2OMe H O H Gb
CH＝CHCO2Me H CH2OMe H O H Ga
CH＝CHCO2Et H CH2OMe H O H Ga
CH＝CHCO2Pr-n H CH2OMe H O H Gb
CH＝CHCN H CH2OMe H O H Ga
Ph H CH2OMe H O H Ga
R1 R2 R3 R4 X M Gn
CH2Ph H CH2OMe H O H Ga
OPh H CH2OMe H O H Ga
SPh H CH2OMe H O H Ga
SO2Ph H CH2OMe H O H Ga
CONHMe H CH2OMe H O H Ga
CONHEt H CH2OMe H O H Ga
CON(Me)2 H CH2OMe H O H Ga
CON(Et)2 H CH2OMe H O H Ga
F H CH2SMe H O H Ga
Cl H CH2SMe H O H Ga
Br H CH2SMe H O H Ga
I H CH2SMe H O H Ga
CH＝CH2 H CH2SMe H O H Ga
CH2CH＝CH2 H CH2SMe H O H Ga
C≡OH H CH2SMe H O H Ga
CH2C≡CH H CH2SMe H O H Ga
CH2F H CH2SMe H O H Ga
CHF2 H CH2SMe H O H Ga
CN H CH2SMe H O H Ga
NH2 H GH2SMe H O H Ga
NHCOMe H CH2SMe H O H Ga
CH2NH2 H CH2SMe H O H Ga
CH2NHCOMe H CH2SMe H O H Ga
CH2OCHF2 H CH2SMe H O H Ga
CF3 H CH2SMe H O H Ga
NO2 H CH2SMe H O H Gb
OMe H CH2SMe H O H Ga
OEt H CH2SMe H O H Ga
OPr-n H CH2SMe H O H Gb
SMe H CH2SMe H O H Ga
SEt H CH2SMe H O H Ga
SO2Me H CH2SMe H O H Ga
SO2Et H CH2SMe H O H Ga
COMe H CH2SMe H O H Ga
COEt H CH2SMe H O H Ga
CO2H H CH2SMe H O H Gb
CO2Me H CH2SMe H O H Ga
CO2Et H CH2SMe H O H Ga
CO2Pr-n H CH2SMe H O H Gb
CO2Bu-n H CH2SMe H O H Gc
R1 R2 R3 R4 X M Gn
CH2Cl H CH2SMe H O H Ga
CH2Br H CH2SMe H O H Gb
CH2I H CH2SMe H O H Gb
CH2CF3 H CH2SMe H O H Ga
CH2CN H CH2SMe H O H Ga
CH2OH H CH2SMe H O H Gb
CH2OMe H CH2SMe H O H Ga
CH2OEt H CH2SMe H O H Ga
CH2OPr-n H CH2SMe H O H Gb
CH2SMe H CH2SMe H O H Ga
CH2SEt H CH2SMe H O H Ga
CH2SPr-n H CH2SMe H O H Gb
CH2SO2Me H CH2SMe H O H Ga
CH2SO2Et H CH2SMe H O H Ga
CH2COMe H CH2SMe H O H Ga
CH2COEt H CH2SMe H O H Ga
CH2COPr-n H CH2SMe H O H Gb
CH2CO2H H CH2SMe H O H Gb
CH2CO2Me H CH2SMe H O H Ga
CH2CO2Et H CH2SMe H O H Ga
CH2CO2Pr-n H CH2SMe H O H Gb
CH2OCH2CH＝CH2H CH2SMe H O H Gb
CH2OCH2C≡CH H CH2SMe H O H Gb
CH＝CHCO2Me H CH2SMe H O H Ga
CH＝CHCO2Et H CH2SMe H O H Ga
CH＝CHCO2Pr-n H CH2SMe H O H Gb
CH＝CHCN H CH2SMe H O H Ga
Ph H CH2SMe H O H Ga
CH2Ph H CH2SMe H O H Ga
OPh H CH2SMe H O H Ga
SPh H CH2SMe H O H Ga
SO2Ph H CH2SMe H O H Ga
CONHMe H CH2SMe H O H Ga
CONHEt H CH2SMe H O H Ga
CON(Me)2 H CH2SMe H O H Ga
CON(Et)2 H CH2SMe H O H Ga
F H CH2SO2Me H O H Ga
Cl H CH2SO2Me H O H Ga
Br H CH2SO2Me H O H Ga
I H CH2SO2Me H O H Ga
R1 R2 R3 R4 X M Gn
CH＝CH2 H CH2SO2Me H O H Ga
CH2CH＝CH2 H CH2SO2Me H O H Ga
C≡CH H CH2SO2Me H O H Ga
CH2C≡CH H CH2SO2Me H O H Ga
CH2F H CH2SO2Me H O H Ga
CHF2 H CH2SO2Me H O H Ga
CN H CH2SO2Me H O H Ga
NH2 H CH2SO2Me H O H Ga
NHCOMe H CH2SO2Me H O H Ga
GH2NH2 H CH2SO2He H O H Ga
CH2NHCOMe H CH2SO2Me H O H Ga
CH2OCHF2 H CH2SO2Me H O H Ga
CF3 H CH2SO2Me H O H Ga
NO2 H CH2SO2Me H O H Gb
OMe H CH2SO2Me H O H Ga
OEt H CH2SO2Me H O H Ga
OPr-n H CH2SO2Me H O H Gb
SMe H CH2SO2Me H O H Ga
SEt H CH2SO2Me H O H Ga
SO2Me H CH2SO2Me H O H Ga
SO2Et H CH2SO2Me H O H Ga
COMe H CH2SO2Me H O H Ga
COEt H CH2SO2Me H O H Ga
CO2H H CH2SO2Me H O H Gb
CO2Me H CH2SO2Me H O H Ga
CO2Et H CH2SO2Me H O H Ga
CO2Pr-n H CH2SO2Me H O H Gb
CO2Bu-n H CH2SO2Me H O H Gc
CH2Cl H CH2SO2Me H O H Ga
CH2Br H CH2SO2Me H O H Gb
CH2I H CH2SO2Me H O H Gb
CH2CF3 H CH2SO2Me H O H Ga
CH2CN H CH2SO2Me H O H Ga
CH2OH H CH2SO2Me H O H Gb
CH2OMe H CH2SO2Me H O H Ga
CH2OEt H CH2SO2Me H O H Ga
CH2OPr-n H CH2SO2Me H O H Gb
CH2SMe H CH2SO2Me H O H Ga
CH2SEt H CH2SO2Me H O H Ga
CH2SPr-n H CH2SO2Me H O H Gb
R1 R2 R3 R4 X M Gn
CH2SO2Me H CH2SO2Me H O H Ga
CH2SO2Et H CH2SO2Me H O H Ga
CH2COMe H CH2SO2Me H O H Ga
CH2COEt H CH2SO2Me H O H Ga
CH2COPr-n H CH2SO2Me H O H Gb
CH2CO2H H CH2SO2Me H O H Gb
CH2CO2Me H CH2SO2Me H O H Ga
CH2CO2Et H CH2SO2Me H O H Ga
CH2CO2Pr-n H CH2SO2Me H O H Gb
CH2OCH2CH2CH2 H CH2SO2Me H O H Gb
CH2OCH2C≡CH H CH2SO2Me H O H Gb
CH＝CHCO2Me H CH2SO2Me H O H Ga
CH＝CHCO2Et H CH2SO2Me H O H Ga
CH＝CHCO2Pr-n H CH2SO2Me H O H Gb
CH＝CHCN H CH2SO2Me H O H Ga
Ph H CH2SO2Me H O H Ga
CH2Ph H CH2SO2Me H O H Ga
OPh H CH2SO2Me H O H Ga
SPh H CH2SO2Me H O H Ga
SO2Ph H CH2SO2Me H O H Ga
CONHMe H CH2SO2Me H O H Ga
CONHEt H CH2SO2Me H O H Ga
CON(Me) H CH2SO2Me H O H Ga
CON(Et) H CH2SO2Me H O H Ga
F H Ph H O H Ga
Cl H Ph H O H Ga
Br H Ph H O H Ga
I H Ph H O H Ga
CH＝CH2 H Ph H O H Ga
CH2CH＝CH2 H Ph H O H Ga
C≡CH H Ph H O H Ga
CH2C≡CH H Ph H O H Ga
CH2F H Ph H O H Ga
CHF2 H Ph H O H Ga
CN H Ph H O H Ga
NH2 H Ph H O H Ga
NHCOMe H Ph H O H Ga
CH2NH2 H Ph H O H Ga
CH2NHCOMe H Ph H O H Ga
CH2OCHF2 H Ph H O H Ga
R1 R2 R3 R4 X M Gn
CF3 H Ph H O H Ga
NO2 H Ph H O H Gb
OMe H Ph H O H Ga
OEt H Ph H O H Ga
OPr-n H Ph H O H Gb
SMe H Ph H O H Ga
SEt H Ph H O H Ga
SO2Me H Ph H O H Ga
SO2Et H Ph H O H Ga
COMe H Ph H O H Ga
COEt H Ph H O H Ga
CO2H H Ph H O H Gb
CO2Me H Ph H O H Ga
CO2Et H Ph H O H Ga
CO2Pr-n H Ph H O H Gb
CO2Bu-n H Ph H O H Gc
CH2Cl H Ph H O H Ga
CH2Br H Ph H O H Gb
CH2I H Ph H O H Gb
CH2CF3 H Ph H O H Ga
CH2CN H Ph H O H Ga
CH2OH H Ph H O H Gb
CH2OMe H Ph H O H Ga
CH2OEt H Ph H O H Ga
CH2OPr-n H Ph H O H Gb
CH2SMe H Ph H O H Ga
CH2SEt H Ph H O H Ga
CH2SPr-n H Ph H O H Gb
CH2SO2Me H Ph H O H Ga
CH2SO2Et H Ph H O H Ga
CH2COMe H Ph H O H Ga
CH2COEt H Ph H O H Ga
CH2COPr-n H Ph H O H Cb
CH2CO2H H Ph H O H Cb
CH2CO2Me H Ph H O H Ga
CH2CO2Et H Ph H O H Ga
CH2CO2Pr-n H Ph H O H Gb
CH2OCH2CH＝CH2 H Ph H O H Gb
CH2OCH2C≡CH H Ph H O H Gb
CH＝CHCO2Me H Ph H O H Ga
R1 R2 R3 R4 X M Gn
CH＝CHCO2Et H Ph H O H Ga
CH＝CHCO2Pr-n H Ph H O H Gb
CH＝CHCN H Ph H O H Ga
Ph H Ph H O H Ga
CH2Ph H Ph H O H Ga
OPh H Ph H O H Ga
SPh H Ph H O H Ga
SO2Ph H Ph H O H Ga
CONHMe H Ph H O H Ga
CONHEt H Ph H O H Ga
CON(Me)2 H Ph H O H Ga
CON(Et)2 H Ph H O H Ga
F H CH2Ph H O H Ga
Cl H CH2Ph H O H Ga
Br H CH2Ph H O H Ga
I H CH2Ph H O H Ga
CH＝CH2 H CH2Ph H O H Ga
CH2CH＝CH2 H CH2Ph H O H Ga
C≡CH H CH2Ph H O H Ga
CH2C≡CH H CH2Ph H O H Ga
CH2F H CH2Ph H O H Ga
CHF H CH2Ph H O H Ga
CN H CH2Ph H O H Ga
NH2 H CH2Ph H O H Ga
NHCO H CH2Ph H O H Ga
CH2NH2 H CH2Ph H O H Ga
CH2NHCOMe H CH2Ph H O H Ga
CH2OCHF2 H CH2Ph H O H Ga
CF3 H CH2Ph H O H Ga
NO2 H CH2Ph H O H Ga
OHe H CH2Ph H O H Gb
OEt H CH2Ph H O H Ga
OPr-n H CH2Ph H O H Ga
SMe H CH2Ph H O H Gb
SEt H CH2Ph H O H Ga
SO2Me H CH2Ph H O H Ga
SO2Et H CH2Ph H O H Ga
COMe H CH2Ph H O H Ga
COEt H CH2Ph H O H Ga
CO2H H CH2Ph H O H Gb
R1 R2 R3 R4 X M Gn
CO2Me H CH2Ph H O H Ga
CO2Et H CH2Ph H O H Ga
CO2Pr-n H CH2Ph H O H Gb
CO2Bu-n H CH2Ph H O H Gc
CH2Cl H CH2Ph H O H Ga
CH2Br H CH2Ph H O H Gb
CH2I H CH2Ph H O H Gb
CH2CF3 H CH2Ph H O H Ga
CH2CN H CH2Ph H O H Ga
CH2OH H CH2Ph H O H Gb
CH2OMe H CH2Ph H O H Ga
CH2OEt H CH2Ph H O H Ga
CH2OPr-n H CH2Ph H O H Gb
CH2SMe H CH2Ph H O H Ga
CH2SEt H CH2Ph H O H Ga
CH2SPr-n H CH2Ph H O H Gb
CH2SO2Me H CH2Ph H O H Ga
CH2SO2Et H CH2Ph H O H Ga
CH2SOMe H CH2Ph H O H Ga
CH2COEt H CH2Ph H O H Ga
CH2COPr-n H CH2Ph H O H Gb
CH2CO2H H CH2Ph H O H Gb
CH2CO2Me H CH2Ph H O H Ga
CH2CO2Et H CH2Ph H O H Ga
CH2CO2Pr-n H Ch2Ph H O H Ga
CH2OCH2CH＝CH H CH2Ph H O H Gb
CH2OCH2C≡CH H CH2Ph H O H Gb
CH＝CHCO2Me H CH2Ph H O H Gb
CH＝CHCO2Et H CH2Ph H O H Ga
CH＝CHCO2Pr-n H CH2Ph H O H Gb
CH＝CHCN H CH2Ph H O H Ga
Ph H CH2Ph H O H Ga
CH2Ph H CH2Ph H O H Ga
OPh H CH2Ph H O H Ga
SPh H CH2Ph H O H Ga
SO2Ph H CH2Ph H O H Ga
CONHMe H CH2Ph H O H Ga
CONHEt H CH2Ph H O H Ga
CON(Me)2 H CH2Ph H O H Ga
CON(Et)2 H CH2Ph H O H Ga
R1 R2 R3 R4 X M Gn
F H OPh H O H Ga
Cl H OPh H O H Ga
Br H OPh H O H Ga
I H OPh H O H Ga
CH＝CH2 H OPh H O H Ga
CH2CH＝CH2 H OPh H O H Ga
C≡CH H OPh H O H Ga
CH2C≡CH H OPh H O H Ga
CH2F H OPh H O H Ga
CHF2 H OPh H O H Ga
CN H OPh H O H Ga
NH2 H OPh H O H Ga
NHCOMe H OPh H O H Ga
CH2NH2 H OPh H O H Ga
CH2NHCOMe H OPh H O H Ga
CH2OCHF2 H OPh H O H Ga
CF3 H OPh H O H Ga
NO2 H OPh H O H Gb
OMe H OPh H O H Ga
OEt H OPh H O H Ga
OPr-n H OPh H O H Gb
SMe H OPh H O H Ga
SEt H OPh H O H Ga
SO2Me H OPh H O H Ga
SO2Et H OPh H O H Ga
COMe H OPh H O H Ga
COEt H OPh H O H Ga
CO2H H OPh H O H Gb
CO2Me H OPh H O H Ga
CO2Et H OPh H O H Ga
CO2Pr-n H OPh H O H Gb
CO2Bu-n H OPh H O H Gc
CH2Cl H OPh H O H Ga
CH2Br H OPh H O H Gb
CH2I H OPh H O H Gb
CH2CF3 H OPh H O H Ga
CH2CN H OPh H O H Ga
CH2OH H OPh H O H Gb
CH2OMe H OPh H O H Ga
CH2OEt H OPh H O H Ga
R1 R2 R3 R4 X M Gn
CH2OPr-n H OPh H O H Gb
CH2SMe H OPh H O H Ga
CH2SEt H OPh H O H Ga
CH2SPr-n H OPh H O H Gb
CH2SO2Me H OPh H O H Ga
CH2SO2Et H OPh H O H Ga
CH2COMe H OPh H O H Ga
CH2COEt H OPh H O H Ga
CH2COPr-n H OPh H O H Gb
CH2CO2H H OPh H O H Gb
CH2CO2Me H OPh H O H Ga
CH2CO2Et H OPh H O H Ga
CH2CO2Pr-n H OPh H O H Gb
CH2OCH2CH＝CH2H OPh H O H Gb
CH2OCH2C≡CH H OPh H O H Gb
CH＝CHCO2Me H OPh H O H Ga
CH＝CHCO2Et H OPh H O H Ga
CH＝CHCO2Pr-n H OPh H O H Gb
CH＝CHCN H OPh H O H Ga
Ph H OPh H O H Ga
CH2Ph H OPh H O H Ga
OPh H OPh H O H Ga
SPh H OPh H O H Ga
SO2Ph H OPh H O H Ga
CONHMe H OPh H O H Ga
CONHEt H OPh H O H Ga
CON(Me)2 H OPh H O H Ga
CON(Et)2 H OPh H O H Ga
F H SPh H O H Ga
Cl H SPh H O H Ga
Br H SPh H O H Ga
I H SPh H O H Ga
CH＝CH2 H SPh H O H Ga
CH2CH＝CH2 H SPh H O H Ga
C≡CH H SPh H O H Ga
CH2C≡CH H SPh H O H Ga
CH2F H SPh H O H Ga
CHF2 H SPh H O H Ga
CN H SPh H O H Ga
NH2 H SPh H O H Ga
R1 R2 R3 R4 X M Gn
NHCOMe H SPh H O H Ga
CH2NH2 H SPh H O H Ga
CH2NHCOMe H SPh H O H Ga
CH2OCHF2 H SPh H O H Ga
CF3 H SPh H O H Ga
NO2 H SPh H O H Gb
OMe H SPh H O H Ga
OEt H SPh H O H Ga
OPr-n H SPh H O H Gb
SMe H SPh H O H Ga
SEt H SPh H O H Ga
SO2Me H SPh H O H Ga
SO2Et H SPh H O H Ga
COMe H SPh H O H Ga
COEt H SPh H O H Ga
CO2H H SPh H O H Gb
CO2Me H SPh H O H Ga
CO2Et H SPh H O H Ga
CO2Pr-n H SPh H O H Gb
CO2Bu-n H SPh H O H Gc
CH2Cl H SPh H O H Ga
CH2Br H SPh H O H Gb
CH2I H SPh H O H Gb
CH2CF3 H SPh H O H Ga
CH2CN H SPh H O H Ga
CH2OH H SPh H O H Gb
CH2OMe H SPh H O H Ga
CH2OEt H SPh H O H Ga
CH2OPr-n H SPh H O H Gb
CH2SMe H SPh H O H Ga
CH2SEt H SPh H O H Ga
CH2SPr-n H SPh H O H Gb
CH2SO2Me H SPh H O H Ga
CH2SO2Et H SPh H O H Ga
CH2COMe H SPh H O H Ga
CH2COEt H SPh H O H Ga
CH2COPr-n H SPh H O H Gb
CH2CO2H H SPh H O H Gb
CH2CO2Me H SPh H O H Ga
CH2CO2Et H SPh H O H Ga
R1 R2 R3 R4 X M Gn
CH2CO2Pr-n H SPh H O H Gb
CH2OCH2CH＝CH2 H SPh H O H Gb
CH2OCH2C≡CH H SPh H O H Gb
CH＝CHCO2Me H SPh H O H Ga
CH＝CHCO2Et H SPh H O H Ga
CH＝CHCO2Pr-n H SPh H O H Gb
CH＝CHCN H SPh H O H Ga
Ph H SPh H O H Ga
CH2Ph H SPh H O H Ga
OPh H SPh H O H Ga
SPh H SPh H O H Ga
SO2Ph H SPh H O H Ga
CONHMe H SPh H O H Ga
CONHEt H SPh H O H Ga
CON(Me)2 H SPh H O H Ga
CON(Et)2 H SPh H O H Ga
F H SO2Ph H O H Ga
Cl H SO2Ph H O H Ga
Br H SO2Ph H O H Ga
I H SO2Ph H O H Ga
CH＝CH2 H SO2Ph H O H Ga
CH2CH＝CH2 H SO2Ph H O H Ga
C≡CH H SO2Ph H O H Ga
CH2C≡CH H SO2Ph H O H Ga
CH2F H SO2Ph H O H Ga
CHF2 H SO2Ph H O H Ga
CN H SO2Ph H O H Ga
NH2 H SO2Ph H O H Ga
NHCOMe H SO2Ph H O H Ga
CH2NH2 H SO2Ph H O H Ga
CH2NHCOMe H SO2Ph H O H Ga
CH2OCHF2 H SO2Ph H O H Ga
CF3 H SO2Ph H O H Ga
NO2 H SO2Ph H O H Gb
OMe H SO2Ph H O H Ga
OEt H SO2Ph H O H Ga
OPr-n H SO2Ph H O H Gb
SMe H SO2Ph H O H Ga
SEt H SO2Ph H O H Ga
SO2Me H SO2Ph H O H Ga
R1 R2 R3 R4 X M Gn
SO2Et H SO2Ph H O H Ga
COMe H SO2Ph H O H Ga
COEt H SO2Ph H O H Ga
CO2H H SO2Ph H O H Gb
CO2Me H SO2Ph H O H Ga
CO2Et H SO2Ph H O H Ga
CO2Pr-n H SO2Ph H O H Gb
CO2Bu-n H SO2Ph H O H Gc
CH2Cl H SO2Ph H O H Ga
CH2Br H SO2Ph H O H Gb
CH2I H SO2Ph H O H Gb
CH2CF3 H SO2Ph H O H Ga
CH2CN H SO2Ph H O H Ga
CH2OH H SO2Ph H O H Gb
CH2OMe H SO2Ph H O H Ga
CH2OEt H SO2Ph H O H Ga
CH2OPr-n H SO2Ph H O H Gb
CH2SMe H SO2Ph H O H Ga
CH2SEt H SO2Ph H O H Ga
CH2SPr-n H SO2Ph H O H Gb
CH2SO2Me H SO2Ph H O H Ga
CH2SO2Et H SO2Ph H O H Ga
CH2COMe H SO2Ph H O H Ga
CH2COEt H SO2Ph H O H Ga
CH2COPr-n H SO2Ph H O H Gb
CH2CO2H H SO2Ph H O H Gb
CH2CO2Me H SO2Ph H O H Ga
CH2CO2Et H SO2Ph H O H Ga
CH2CO2Pr-n H SO2Ph H O H Gb
CH2OCH2CH＝CH2H SO2Ph H O H Gb
CH2OCH2C≡CH H SO2Ph H O H Gb
CH＝CHCO2Me H SO2Ph H O H Ga
CH＝CHCO2Et H SO2Ph H O H Ga
CH＝CHCO2Pr-n H SO2Ph H O H Gb
CH＝CHCN H SO2Ph H O H Ga
Ph H SO2Ph H O H Ga
CH2Ph H SO2Ph H O H Ga
OPh H SO2Ph H O H Ga
SPh H SO2Ph H O H Ga
SO2Ph H SO2Ph H O H Ga
R1 R2 R3 R4 X M Gn
CONHMe H SO2Ph H O H Ga
CONHEt H SO2Ph H O H Ga
CON(Me)2 H SO2Ph H O H Ga
CON(Et)2 H SO2Ph H O H Ga
F H CON(Et)2 H O H Ga
Cl H CON(Et)2 H O H Ga
Br H CON(Et)2 H O H Ga
I H CON(Et)2 H O H Ga
CH＝CH2 H CON(Et)2 H O H Ga
CH2CH＝CH2 H CON(Et)2 H O H Ga
C≡CH H CON(Et)2 H O H Ga
CH2C≡CH H CON(Et)2 H O H Ga
CH2F H CON(Et)2 H O H Ga
CHF2 H CON(Et)2 H O H Ga
CN H CON(Et)2 H O H Ga
NH2 H CON(Et)2 H O H Ga
NHCOMe H CON(Et)2 H O H Ga
CH2NH2 H CON(Et)2 H O H Ga
CH2NHCOMe H CON(Et)2 H O H Ga
CH2OCHF2 H CON(Et)2 H O H Ga
CF3 H CON(Et)2 H O H Ga
NO2 H CON(Et)2 H O H Gb
OMe H CON(Et)2 H O H Ga
OEt H CON(Et)2 H O H Ga
OPr-n H CON(Et)2 H O H Gb
SMe H CON(Et)2 H O H Ga
SEt H CON(Et)2 H O H Ga
SO2Me H CON(Et)2 H O H Ga
SO2Et H CON(Et)2 H O H Ga
COMe H CON(Et)2 H O H Ga
COEt H CON(Et)2 H O H Ga
CO2H H CON(Et)2 H O H Gb
CO2Me H CON(Et)2 H O H Ga
CO2Et H CON(Et)2 H O H Ga
CO2Pr-n H CON(Et)2 H O H Ga
CO2Bu-n H CON(Et)2 H O H Gc
CH2Cl H CON(Et)2 H O H Ga
CH2Br H CON(Et)2 H O H Gb
CH2I H CON(Et)2 H O H Gb
CH2CF3 H CON(Et)2 H O H Ga
R1 R2 R3 R4 X M Gn
CH2CN H CON(Et)2 H O H Ga
CH2OH H CON(Et)2 H O H Gb
CH2OMe H CON(Et)2 H O H Ga
CH2OEt H CON(Et)2 H O H Ga
CH2OPr-n H CON(Et)2 H O H Gb
CH2SMe H CON(Et)2 H O H Ga
CH2SEt H CON(Et)2 H O H Ga
CH2SPr-n H CON(Et)2 H O H Gb
CH2SO2Me H CON(Et)2 H O H Ga
CH2SO2Et H CON(Et)2 H O H Ga
CH2COMe H CON(Et)2 H O H Ga
CH2COEt H CON(Et)2 H O H Ga
CH2COPr-n H CON(Et)2 H O H Gb
CH2CO2H H CON(Et)2 H O H Gb
CH2CO2Me H CON(Et)2 H O H Ga
CH2CO2Et H CON(Et)2 H O H Ga
CH2CO2Pr-n H CON(Et)2 H O H Gb
CH2OCH2CH＝CH2 H CON(Et)2 H O H Gb
CH2OCH2C≡CH H CON(Et)2 H O H Gb
CH＝CHCO2Me H CON(Et)2 H O H Ga
CH＝CHCO2Et H CON(Et)2 H O H Ga
CH＝CHCO2Pr-n H CON(Et)2 H O H Gb
CH＝CHCN H CON(Et)2 H O H Ga
Ph H CON(Et)2 H O H Ga
CH2Ph H CON(Et)2 H O H Ga
OPh H CON(Et)2 H O H Ga
SPh H CON(Et)2 H O H Ga
SO2Ph H CON(Et)2 H O H Ga
CONHMe H CON(Et)2 H O H Ga
CONHEt H CON(Et)2 H O H Ga
CON(Me)2 H CON(Et)2 H O H Ga
CON(Et)2 H CON(Et)2 H O H Ga
F H CN H O H Ga
Cl H CN H O H Ga
Br H CN H O H Ga
I H CN H O H Ga
CH＝CH2 H CN H O H Ga
CH2CH＝CH2 H CN H O H Ga
C≡CH H CN H O H Ga
CH2C≡CH H CN H O H Ga
R1 R2 R3 R4 X M Gn
CH2F H CN H O H Ga
CHF2 H CN H O H Ga
CN H CN H O H Ga
NH2 H CN H O H Ga
NHCOMe H CN H O H Ga
CH2NH2 H CN H O H Ga
CH2NHCOMe H CN H O H Ga
CH2OCHF2 H CN H O H Ga
CF3 H CN H O H Ga
NO2 H CN H O H Gb
OMe H CN H O H Ga
OEt H CN H O H Ga
OPr-n H CN H O H Gb
SMe H CN H O H Ga
SEt H CN H O H Ga
SO2Me H CN H O H Ga
SO2Et H CN H O H Ga
COMe H CN H O H Ga
COEt H CN H O H Ga
CO2H H CN H O H Gb
CO2Me H CN H O H Ga
CO2Et H CN H O H Ga
CO2Pr-n H CN H O H Gb
CO2Bu-n H CN H O H Gc
CH2Cl H CN H O H Ga
CH2Br H CN H O H Gb
CH2I H CN H O H Gb
CH2CF3 H CN H O H Ga
CH2CN H CN H O H Ga
CH2OH H CN H O H Gb
CH2OMe H CN H O H Ga
CH2OEt H CN H O H Ga
CH2OPr-n H CN H O H Gb
CH2SMe H CN H O H Ga
CH2SEt H CN H O H Ga
CH2SPr-n H CN H O H Gb
CH2SO2Me H CN H O H Ga
CH2SO2Et H CN H O H Ga
CH2COMe H CN H O H Ga
CH2COEt H CN H O H Ga
R1 R2 R3 R4 X M Gn
CH2COPr-n H CN H O H Gb
CH2CO2H H CN H O H Gb
CH2CO2Me H CN H O H Ga
CH2CO2Et H CN H O H Ga
CH2CO2Pr-n H CN H O H Gb
CH2OCH2CH＝CH2H CN H O H Gb
CH2OCH2C≡CH H CN H O H Gb
CH＝CHCO2Me H CN H O H Ga
CH＝CHCO2Et H CN H O H Ga
CH＝CHCO2Pr-n H CN H O H Gb
CH＝CHCN H CN H O H Ga
Ph H CN H O H Ga
CH2Ph H CN H O H Ga
OPh H CN H O H Ga
SPh H CN H O H Ga
SO2Ph H CN H O H Ga
CONHMe H CN H O H Ga
CONHEt H CN H O H Ga
CON(Me)2 H CN H O H Ga
CON(Et)2 H CN H O H Ga
F H Et H O H Ga
Cl H Et H O H Ga
Br H Et H O H Ga
I H Et H O H Ga
CH＝CH2 H Et H O H Ga
CH2CH＝CH2 H Et H O H Ga
C≡CH H Et H O H Ga
CH2C≡CH H Et H O H Ga
CH2F H Et H O H Ga
CHF2 H Et H O H Ga
CN H Et H O H Ga
NH2 H Et H O H Ga
NHCOMe H Et H O H Ga
CH2NH2 H Et H O H Ga
CH2NHCOMe H Et H O H Ga
CH2OCHF2 H Et H O H Ga
CF3 H Et H O H Ga
NO2 H Et H O H Gb
OMe H Et H O H Ga
OEt H Et H O H Ga
R1 R2 R3 R4 X M Gn
OPr-n H Et H O H Gb
SMe H Et H O H Ga
SEt H Et H O H Ga
SO2Me H Et H O H Ga
SO2Et H Et H O H Ga
COMe H Et H O H Ga
COEt H Et H O H Ga
CO2H H Et H O H Gb
CO2Me H Et H O H Ga
CO2Et H Et H O H Ga
CO2Pr-n H Et H O H Gb
CO2Bu-n H Et H O H Gc
CH2Cl H Et H O H Ga
CH2Br H Et H O H Gb
CH2I H Et H O H Gb
CH2CF3 H Et H O H Ga
CH2CN H Et H O H Ga
CH2OH H Et H O H Gb
CH2OMe H Et H O H Ga
CH2OEt H Et H O H Ga
CH2OPr-n H Et H O H Gb
CH2SMe H Et H O H Ga
CH2SEt H Et H O H Ga
CH2SPr-n H Et H O H Gb
CH2SO2Me H Et H O H Ga
CH2SO2Et H Et H O H Ga
CH2COMe H Et H O H Ga
CH2COEt H Et H O H Ga
CH2COPr-n H Et H O H Gb
CH2CO2H H Et H O H Gb
CH2CO2Me H Et H O H Ga
CH2CO2Et H Et H O H Ga
CH2CO2Pr-n H Et H O H Gb
CH2OCH2CH＝CH2 H Et H O H Gb
CH2OCH2C≡CH H Et H O H Gb
CH＝CHCO2Me H Et H O H Ga
CH＝CHCO2Et H Et H O H Ga
CH＝CHCO2Pr-n H Et H O H Gb
CH＝CHCN H Et H O H Ga
Ph H Et H O H Ga
R1 R2 R3 R4 X M Gn
CH2Ph H Et H O H Ga
OPh H Et H O H Ga
SPh H Et H O H Ga
SO2Ph H Et H O H Ga
CONHMe H Et H O H Ga
CONHEt H Et H O H Ga
CON(Me)2 H Et H O H Ga
CON(Et)2 H Et H O H Ga
Cl Cl H H O H Ga
Cl Cl H H S H G3
H Cl Cl H O H Ga
H Cl Cl H S H G3
Br Br H H O H Ga
Br Br H H S H G3
Br H Br H O H Ga
Br H Br H S H G3
H Br Br H O H Ga
H Br Br H S H G3
H Cl Me H O H Ga
H Cl Me H S H G3
Me Cl H H O H Ga
Me Cl H H S H G3
H Br Me H O H Ga
H Br Me H S H G3
Me Br H H O H Ga
Me Br H H S H G3
R3 R2 R1 R4 X M Gn
F H Me H O H Ga
Cl H Me H O H Ga
Br H Me H O H Ga
I H Me H O H Ga
CH＝CH2 H Me H O H Ga
CH2CH＝CH2 H Me H O H Ga
C≡CH H Me H O H Ga
CH2C≡CH H Me H O H Ga
CH2F H Me H O H Ga
CHF2 H Me H O H Ga
CN H Me H O H Ga
NH2 H Me H O H Ga
NHCOMe H Me H O H Ga
CH2NH2 H Me H O H Ga
CH2NHCOMe H Me H O H Ga
CH2OCHF2 H Me H O H Ga
CF3 H Me H O H Ga
NO2 H Me H O H Gb
OMe H Me H O H Ga
OEt H Me H O H Ga
OPr-n H Me H O H Gb
SMe H Me H O H Ga
SEt H Me H O H Ga
SO2Me H Me H O H Ga
SO2Et H Me H O H Ga
COMe H Me H O H Ga
COEt H Me H O H Ga
CO2H H Me H O H Gb
CO2Me H Me H O H Ga
CO2Et H Me H O H Ga
CO2Pr-n H Me H O H Gb
CO2Bu-n H Me H O H Gc
CH2Cl H Me H O H Ga
CH2Br H Me H O H Gb
CH2I H Me H O H Gb
CH2CF3 H Me H O H Ga
CH2CN H Me H O H Ga
CH2OH H Me H O H Gb
CH2OMe H Me H O H Ga
CH2OEt H Me H O H Ga
R3 R2 R1 R4 X M Gn
CH2OPr-n H Me H O H Gb
CH2SMe H Me H O H Ga
CH2SEt H Me H O H Ga
CH2SPr-n H Me H O H Gb
CH2SO2Me H Me H O H Ga
CH2SO2Et H Me H O H Ga
CH2COMe H Me H O H Ga
CH2COEt H Me H O H Ga
CH2COPr-n H Me H O H Gb
CH2CO2H H Me H O H Gb
CH2CO2Me H Me H O H Ga
CH2CO2Et H Me H O H Ga
CH2CO2Pr-n H Me H O H Gb
CH2OCH2CH＝CH2H Me H O H Gb
CH2OCH2C≡CH H Me H O H Gb
CH＝CHCO2Me H Me H O H Ga
CH＝CHCO2Et H Me H O H Ga
CH＝CHCO2Pr-n H Me H O H Gb
CH＝CHCN H Me H O H Ga
Ph H Me H O H Ga
CH2Ph H Me H O H Ga
OPh H Me H O H Ga
SPh H Me H O H Ga
SO2Ph H Me H O H Ga
CONHMe H Me H O H Ga
CONHEt H Me H O H Ga
CON(Me)2 H Me H O H Ga
CON(Et)2 H Me H O H Ga
F Me H H O H Ga
Cl Me H H O H Ga
Br Me H H O H Ga
I Me H H O H Ga
CH＝CH2 Me H H O H Ga
CH2CH＝CH2 Me H H O H Ga
C≡CH Me H H O H Ga
CH2C≡CH Me H H O H Ga
CH2F Me H H O H Ga
CHF2 Me H H O H Ga
CN Me H H O H Ga
NH2 Me H H O H Ga
R3 R2 R1 R4 X M Gn
NHCOMe Me H H O H Ga
CH2NH2 Me H H O H Ga
CH2NHCOMe Me H H O H Ga
CH2OCHF2 Me H H O H Ga
CF3 Me H H O H Ga
NO2 Me H H O H Gb
OMe Me H H O H Ga
OEt Me H H O H Ga
OPr-n Me H H O H Gb
SMe Me H H O H Ga
SEt Me H H O H Ga
SO2Me Me H H O H Ga
SO2Et Me H H O H Ga
COMe Me H H O H Ga
COEt Me H H O H Ga
CO2H Me H H O H Gb
CO2Me Me H H O H Ga
CO2Et Me H H O H Ga
CO2Pr-n Me H H O H Gb
CO2Bu-n Me H H O H Gc
CH2Cl Me H H O H Ga
CH2Br Me H H O H Gb
CH2I Me H H O H Gb
CH2CF3 Me H H O H Ga
CH2CN Me H H O H Ga
CH2OH Me H H O H Gb
CH2OMe Me H H O H Ga
CH2OEt Me H H O H Ga
CH2OPr-n Me H H O H Gb
CH2SMe Me H H O H Ga
CH2SEt Me H H O H Ga
CH2SPr-n Me H H O H Gb
CH2SO2Me Me H H O H Ga
CH2SO2Et Me H H O H Ga
CH2COMe Me H H O H Ga
CH2COEt Me H H O H Ga
CH2COPr-n Me H H O H Gb
CH2CO2H Me H H O H Gb
CH2CO2Me Me H H O H Ga
CH2CO2Et Me H H O H Ga
R3 R2 R1 R4 X M Gn
CH2CO2Pr-n Me H H O H Gb
CH2OCH2CH＝CH2 Me H H O H Gb
CH2OCH2C≡CH Me H H O H Gb
CH＝CHCO2Me Me H H O H Ga
CH＝CHCO2Et Me H H O H Ga
CH＝CHCO2Pr-n Me H H O H Gb
CH＝CHCN Me H H O H Ga
Ph Me H H O H Ga
CH2Ph Me H H O H Ga
OPh Me H H O H Ga
SPh Me H H O H Ga
SO2Ph Me H H O H Ga
CONHMe Me H H O H Ga
CONHEt Me H H O H Ga
CON(Me)2 Me H H O H Ga
CON(Et)2 Me H H O H Ga
F Et H H O H Ga
Cl Et H H O H Ga
Br Et H H O H Ga
I Et H H O H Ga
CH＝CH2 Et H H O H Ga
CH2CH＝CH2 Et H H O H Ga
C≡CH Et H H O H Ga
CH2C≡CH Et H H O H Ga
CH2F Et H H O H Ga
CHF2 Et H H O H Ga
CN Et H H O H Ga
NH2 Et H H O H Ga
NHCOMe Et H H O H Ga
CH2NH2 Et H H O H Ga
CH2NHCOMe Et H H O H Ga
CH2OCHF2 Et H H O H Ga
CF3 Et H H O H Ga
NO2 Et H H O H Gb
OMe Et H H O H Ga
OEt Et H H O H Ga
OPr-n Et H H O H Gb
SMe Et H H O H Ga
SEt Et H H O H Ga
SO2Me Et H H O H Ga
R3 R2 R1 R4 X M Gn
SO2Et Et H H O H Ga
COMe Et H H O H Ga
COEt Et H H O H Ga
CO2H Et H H O H Gb
CO2Me Et H H O H Ga
CO2Et Et H H O H Ga
CO2Pr-n Et H H O H Gb
CO2Bu-n Et H H O H Gc
CH2Cl Et H H O H Ga
CN2Br Et H H O H Gb
CH2I Et H H O H Gb
CH2CF3 Et H H O H Ga
CH2CN Et H H O H Ga
CH2OH Et H H O H Gb
CH2OMe Et H H O H Ga
CH2OEt Et H H O H Ga
CH2OPr-n Et H H O H Gb
CH2SMe Et H H O H Ga
CH2SEt Et H H O H Ga
CH2SPr-n Et H H O H Gb
CH2SO2Me Et H H O H Ga
CH2SO2Et Et H H O H Ga
CH2COMe Et H H O H Ga
CH2COEt Et H H O H Ga
CH2COPr-n Et H H O H Gb
CH2CO2H Et H H O H Gb
CH2CO2Me Et H H O H Ga
CH2CO2Et Et H H O H Ga
CH2CO2Pr-n Et H H O H Gb
CH2OCH2CH＝CH2Et H H O H Gb
CH2OCH2C≡CH Et H H O H Gb
CH＝CHCO2Me Et H H O H Ga
CH＝CHCO2Et Et H H O H Ga
CH＝CHCO2Pr-n Et H H O H Gb
CH＝CHCN Et H H O H Ga
Ph Et H H O H Ga
CH2Ph Et H H O H Ga
OPh Et H H O H Ga
SPh Et H H O H Ga
SO2Ph Et H H O H Ga
R3 R2 R1 R4 X M Gn
CONHMe Et H H O H Ga
CONHEt Et H H O H Ga
CON(Me)2 Et H H O H Ga
CON(Et)2 Et H H O H Ga
F H Pr-n H O H Ga
Cl H Pr-n H O H Ga
Br H Pr-n H O H Ga
I H Pr-n H O H Ga
CH＝CH2 H Pr-n H O H Ga
CH2CH＝CH2 H Pr-n H O H Ga
C≡CH H Pr-n H O H Ga
CH2C≡CH H Pr-n H O H Ga
CH2F H Pr-n H O H Ga
CHF2 H Pr-n H O H Ga
CN H Pr-n H O H Ga
NH2 H Pr-n H O H Ga
NHCOMe H Pr-n H O H Ga
CH2NH2 H Pr-n H O H Ga
CH2NHCOMe H Pr-n H O H Ga
CH2OCHF2 H Pr-n H O H Ga
CF3 H Pr-n H O H Ga
NO2 H Pr-n H O H Gb
OMe H Pr-n H O H Ga
OEt H Pr-n H O H Ga
OPr-n H Pr-n H O H Gb
SMe H Pr-n H O H Ga
SEt H Pr-n H O H Ga
SO2Me H Pr-n H O H Ga
SO2Et H Pr-n H O H Ga
COMe H Pr-n H O H Ga
COEt H Pr-n H O H Ga
CO2H H Pr-n H O H Gb
CO2Me H Pr-n H O H Ga
CO2Et H Pr-n H O H Ga
CO2Pr-n H Pr-n H O H Gb
CO2Bu-n H Pr-n H O H Gc
CH2Cl H Pr-n H O H Ga
CH2Br H Pr-n H O H Gb
CH2I H Pr-n H O H Gb
CH2CF3 H Pr-n H O H Ga
R3 R2 R1 R4 X M Gn
CH2CN H Pr-n H O H Ga
CH2OH H Pr-n H O H Gb
CH2OMe H Pr-n H O H Ga
CH2OEt H Pr-n H O H Ga
CH2OPr-n H Pr-n H O H Gb
CH2SMe H Pr-n H O H Ga
CH2SEt H Pr-n H O H Ga
CH2SPr-n H Pr-n H O H Gb
CH2SO2Me H Pr-n H O H Ga
CH2SO2Et H Pr-n H O H Ga
CH2COMe H Pr-n H O H Ga
CH2COHt H Pr-n H O H Ga
CH2COPr-n H Pr-n H O H Gb
CH2CO2H H Pr-n H O H Gb
CH2CO2Me H Pr-n H O H Ga
CH2CO2Et H Pr-n H O H Ga
CH2CO2Pr-n H Pr-n H O H Gb
CH2OCH2CH＝CH2H Pr-n H O H Gb
CH2OCH2C≡CH H Pr-n H O H Gb
CH＝CHCO2Me H Pr-n H O H Ga
CH＝CHCO2Et H Pr-n H O H Ga
CH＝CHCO2Pr-n H Pr-n H O H Gb
CH＝CHCN H Pr-n H O H Ga
Ph H Pr-n H O H Ga
CH2Ph H Pr-n H O H Ga
OPh H Pr-n H O H Ga
SPh H Pr-n H O H Ga
SO2Ph H Pr-n H O H Ga
CONHMe H Pr-n H O H Ga
CONHEt H Pr-n H O H Ga
CON(Me)2 H Pr-n H O H Ga
CON(Et)2 H Pr-n H O H Ga
F H Cl H O H Ga
Cl H Cl H O H Ga
Br H Cl H O H Ga
I H Cl H O H Ga
CH＝CH2 H Cl H O H Ga
CH2CH＝CH2 H Cl H O H Ga
C≡CH H Cl H O H Ga
CH2C≡CH H Cl H O H Ga
R3 R2 R1 R4 X M Gn
CH2F H Cl H O H Ga
CHF2 H Cl H O H Ga
CN H Cl H O H Ga
NH2 H Cl H O H Ga
NHCOMe H Cl H O H Ga
CH2NH2 H Gl H O H Ga
CH2NHCOMe H Cl H O H Ga
CH2OCHF2 H Cl H O H Ga
CF3 H Cl H O H Ga
NO2 H Cl H O H Gb
OMe H Cl H O H Ga
OEt H Cl H O H Ga
OPr-n H Cl H O H Gb
SMe H Cl H O H Ga
SEt H Cl H O H Ga
SO2Me H Cl H O H Ga
SO2Et H Cl H O H Ga
COMe H Cl H O H Ga
COEt H Cl H O H Ga
CO2H H Cl H O H Gb
CO2Me H Cl H O H Ga
CO2Et H Cl H O H Ga
CO2Pr-n H Cl H O H Gb
CO2Bu-n H Cl H O H Gc
CH2Cl H Cl H O H Ga
CH2Br H Cl H O H Gb
CH2I H Cl H O H Gb
CH2CF3 H Cl H O H Ga
CH2CN H Cl H O H Ga
CH2OH H Cl H O H Gb
CH2OMe H Cl H O H Ga
CH2OEt H Cl H O H Ga
CH2OPr-n H Cl H O H Gb
CH2SMe H Cl H O H Ga
CH2SEt H Cl H O H Ga
CH2SPr-n H Cl H O H Gb
CH2SO2Me H Cl H O H Ga
CH2SO2Et H Cl H O H Ga
CH2COMe H Cl H O H Ga
CH2COEt H Cl H O H Ga
R3 R2 R1 R4 X M Gn
CH2COPr-n H Cl H O H Gb
CH2CO2H H Cl H O H Gb
CH2CO2Me H Cl H O H Ga
CH2CO2Et H Cl H O H Ga
CH2CO2Pr-n H Cl H O H Gb
CH2OCH2CH＝CH2H Cl H O H Gb
CH2OCH2C≡CH H Cl H O H Gb
CH＝CHCO2Me H Cl H O H Ga
CH＝CHCO2Et H Cl H O H Ga
CH＝CHCO2Pr-n H Cl H O H Gb
CH＝CHCN H Cl H O H Ga
Ph H Cl H O H Ga
CH2Ph H Cl H O H Ga
OPh H Cl H O H Ga
SPh H Cl H O H Ga
SO2Ph H Cl H O H Ga
CONHNe H Cl H O H Ga
CONHEt H Cl H O H Ga
CON(He)2 H Cl H O H Ga
CON(Et)2 H Cl H O H Ga
F H NO2 H O H Ga
Cl H NO2 H O H Ga
Br H NO2 H O H Ga
I H NO2 H O H Ga
CH＝CH2 H NO2 H O H Ga
CH2CH＝CH2 H NO2 H O H Ga
C≡CH H NO2 H O H Ga
CH2C≡CH H NO2 H O H Ga
CH2F H NO2 H O H Ga
CHF2 H NO2 H O H Ga
CN H NO2 H O H Ga
NH2 H NO2 H O H Ga
NHCOMe H NO2 H O H Ga
CH2NH2 H NO2 H O H Ga
CH2NHCOMe H NO2 H O H Ga
CH2OCHF2 H NO2 H O H Ga
CF3 H NO2 H O H Ga
NO2 H NO2 H O H Gb
OMe H NO2 H O H Ga
OEt H NO2 H O H Ga
R3 R2 R1 R4 X M Gn
OPr-n H NO2 H O H Gb
SMe H NO2 H O H Ga
SEt H NO2 H O H Ga
SO2Me H NO2 H O H Ga
SO2Et H NO2 H O H Ga
COMe H NO2 H O H Ga
COEt H NO2 H O H Ga
CO2H H NO2 H O H Gb
CO2Me H NO2 H O H Ga
CO2Et H NO2 H O H Ga
CO2Pr-n H NO2 H O H Gb
CO2Bu-n H NO2 H O H Gc
CH2Cl H NO2 H O H Ga
CH2Br H NO2 H O H Gb
CH2I H NO2 H O H Gb
CH2CF3 H NO2 H O H Ga
CH2CN H NO2 H O H Ga
CH2OH H NO2 H O H Gb
CH2OMe H NO2 H O H Ga
CH2OEt H NO2 H O H Ga
CH2OPr-n H NO2 H O H Gb
CH2SMe H NO2 H O H Ga
CH2SEt H NO2 H O H Ga
CH2SPr-n H NO2 H O H Gb
CH2SO2Me H NO2 H O H Ga
CH2SO2Et H NO2 H O H Ga
CH2COMe H NO2 H O H Ga
CH2COEt H NO2 H O H Ga
CH2COPr-n H NO2 H O H Gb
CH2CO2H H NO2 H O H Gb
CH2CO2Me H NO2 H O H Ga
CH2CO2Et H NO2 H O H Ga
CH2CO2Pr-n H NO2 H O H Gb
CH2OCH2CH＝CH2H NO2 H O H Gb
CH2OCH2C≡CH H NO2 H O H Gb
CH＝CHCO2Me H NO2 H O H Ga
CH＝CHCO2Et H NO2 H O H Ga
CH＝CHCO2Pr-n H NO2 H O H Gb
CH＝CHCN H NO2 H O H Ga
Ph H NO2 H O H Ga
R3 R2 R1 R4 X M Gn
CH2Ph H NO2 H O H Ga
OPh H NO2 H O H Ga
SPh H NO2 H O H Ga
SO2Ph H NO2 H O H Ga
CONHMe H NO2 H O H Ga
CONHEt H NO2 H O H Ga
CON(Me)2 H NO2 H O H Ga
CON(Et)2 H NO2 H O H Ga
F H CF3 H O H Ga
Cl H CF3 H O H Ga
Br H CF3 H O H Ga
I H CF3 H O H Ga
CH＝CH2 H CF3 H O H Ga
CH2CH＝CH2 H CF3 H O H Ga
C≡CH H CF3 H O H Ga
CH2C≡CH H CF3 H O H Ga
CH2F H CF3 H O H Ga
CHF2 H CF3 H O H Ga
CN H CF3 H O H Ga
NH2 H CF3 H O H Ga
NHCOMe H CF3 H O H Ga
CH2NH2 H CF3 H O H Ga
CH2NHCOMe H CF3 H O H Ga
CH2OCHF2 H CF3 H O H Ga
CF3 H CF3 H O H Ga
NO2 H CF3 H O H Gb
OMe H CF3 H O H Ga
OEt H CF3 H O H Ga
OPr-n H CF3 H O H Gb
SMe H CF3 H O H Ga
SEt H CF3 H O H Ga
SO2Me H CF3 H O H Ga
SO2Et H CF3 H O H Ga
COMe H CF3 H O H Ga
COEt H CF3 H O H Ga
CO2H H CF3 H O H Gb
CO2Me H CF3 H O H Ga
CO2Et H CF3 H O H Ga
CO2Pr-n H CF3 H O H Gb
CO2Bu-n H CF3 H O H Gc
R3 R2 R1 R4 X M Gn
CH2Cl H CF3 H O H Ga
CH2Br H CF3 H O H Gb
CH2I H CF3 H O H Gb
CH2CF3 H CF3 H O H Ga
CH2CN H CF3 H O H Ga
CH2OH H CF3 H O H Gb
CH2OMe H CF3 H O H Ga
CH2OEt H CF3 H O H Ga
CH2OPr-n H CF3 H O H Gb
CH2SMe H CF3 H O H Ga
CH2SEt H CF3 H O H Ga
CH2SPr-n H CF3 H O H Gb
CH2SO2Me H CF3 H O H Ga
CH2SO2Et H CF3 H O H Ga
CH2COMe H CF3 H O H Ga
CH2COEt H CF3 H O H Ga
CH2COPr-n H CF3 H O H Gb
CH2CO2H H CF3 H O H Gb
CH2CO2Me H CF3 H O H Ga
CH2CO2Et H CF3 H O H Ga
CH2CO2Pr-n H CF3 H O H Gb
CH2OCH2CH＝CH2H CF3 H O H Gb
CH2OCH2C≡CH H CF3 H O H Gb
CH＝CHCO2Me H CF3 H O H Ga
CH＝CHCO2Et H CF3 H O H Ga
CH＝CHCO2Pr-n H CF3 H O H Gb
CH＝CHCN H CF3 H O H Ga
Ph H CF3 H O H Ga
CH2Ph H CF3 H O H Ga
OPh H CF3 H O H Ga
SPh H CF3 H O H Ga
SO2Ph H CF3 H O H Ga
CONHMe H CF3 H O H Ga
CONHEt H CF3 H O H Ga
CON(Me)2 H CF3 H O H Ga
CON(Et)2 H CF3 H O H Ga
F H OMe H O H Ga
Cl H OMe H O H Ga
Br H OMe H O H Ga
I H OMe H O H Ga
R3 R2 R1 R4 X M Gn
CH＝CH2 H OMe H O H Ga
CH2CH＝CH2 H OMe H O H Ga
C≡CH H OMe H O H Ga
CH2C≡CH H OMe H O H Ga
CH2F H OMe H O H Ga
CHF2 H OMe H O H Ga
CN H OMe H O H Ga
NH2 H OMe H O H Ga
NHCOMe H OMe H O H Ga
CH2NH2 H OMe H O H Ga
CH2NHCOMe H OMe H O H Ga
CH2OCHF2 H OMe H O H Ga
CF3 H OMe H O H Ga
NO2 H OMe H O H Gb
OMe H OMe H O H Ga
OEt H OMe H O H Ga
OPr-n H OMe H O H Gb
SMe H OMe H O H Ga
SEt H OMe H O H Ga
SO2Me H OMe H O H Ga
SO2Et H OMe H O H Ga
COMe H OMe H O H Ga
COEt H OMe H O H Ga
CO2H H OMe H O H Gb
CO2Me H OMe H O H Ga
CO2Et H OMe H O H Ga
CO2Pr-n H OMe H O H Gb
CO2Bu-n H OMe H O H Gc
CH2Cl H OMe H O H Ga
CH2Br H OMe H O H Gb
CH2I H OMe H O H Gb
CH2CF3 H OMe H O H Ga
CH2CN H OMe H O H Ga
CH2OH H OMe H O H Gb
CH2OMe H OMe H O H Ga
CH2OEt H OMe H O H Ga
CH2OPr-n H OMe H O H Gb
CH2SMe H OMe H O H Ga
CH2SEt H OMe H O H Ga
CH2SPr-n H OMe H O H Gb
R3 R2 R1 R4 X M Gn
CH2SO2Me H OMe H O H Ga
CH2SO2Et H OMe H O H Ga
CH2COMe H OMe H O H Ga
CH2COEt H OMe H O H Ga
CH2COPr-n H OMe H O H Gb
CH2CO2H H OMe H O H Gb
CH2CO2Me H OMe H O H Ga
CH2CO2Et H OMe H O H Ga
CH2CO2Pr-n H OMe H O H Gb
CH2OCH2CH＝CH2H OMe H O H Gb
CH2OCH2C≡CH H OMe H O H Gb
CH＝CHCO2Me H OMe H O H Ga
CH＝CHCO2Et H OMe H O H Ga
CH＝CHCO2Pr-n H OMe H O H Gb
CH＝CHCN H OMe H O H Ga
Ph H OMe H O H Ga
CH2Ph H OMe H O H Ga
OPh H OMe H O H Ga
SPh H OMe H O H Ga
SO2Ph H OMe H O H Ga
CONHMe H OMe H O H Ga
CONHEt H OMe H O H Ga
CON(Me)2 H OMe H O H Ga
CON(Et)2 H OMe H O H Ga
F H SMe H O H Ga
Cl H SMe H O H Ga
Br H SMe H O H Ga
I H SMe H O H Ga
CH＝CH2 H SMe H O H Ga
CH2CH＝CH2 H SMe H O H Ga
C≡CH H SMe H O H Ga
CH2C≡CH H SMe H O H Ga
CH2F H SMe H O H Ga
CHF2 H SMe H O H Ga
CN H SMe H O H Ga
NH2 H SMe H O H Ga
NHCOMe H SMe H O H Ga
CH2NH2 H SMe H O H Ga
CH2NHCOMe H SMe H O H Ga
CH2OCHF2 H SMe H O H Ga
R3 R2 R1 R4 X M Gn
CF3 H SMe H O H Ga
NO2 H SMe H O H Gb
OMe H SMe H O H Ga
OEt H SMe H O H Ga
OPr-n H SMe H O H Gb
SMe H SMe H O H Ga
SEt H SMe H O H Ga
SO2Me H SMe H O H Ga
SO2Et H SMe H O H Ga
COMe H SMe H O H Ga
COEt H SMe H O H Ga
CO2H H SMe H O H Gb
CO2Me H SMe H O H Ga
CO2Et H SMe H O H Ga
CO2Pr-n H SMe H O H Gb
CO2Bu-n H SMe H O H Gc
CH2Cl H SMe H O H Ga
CH2Br H SMe H O H Gb
CH2I H SMe H O H Gb
CH2CF3 H SMe H O H Ga
CH2CN H SMe H O H Ga
CH2OH H SMe H O H Gb
CH2OMe H SMe H O H Ga
CH2OEt H SMe H O H Ga
CH2OPr-n H SMe H O H Gb
CH2SMe H SMe H O H Ga
CH2SEt H SMe H O H Ga
CH2SPr-n H SMe H O H Gb
CH2SO2Me H SMe H O H Ga
CH2SO2Et H SMe H O H Ga
CH2COMe H SMe H O H Ga
CH2COEt H SMe H O H Ga
CH2COPr-n H SMe H O H Gb
CH2CO2H H SMe H O H Gb
CH2CO2Me H SMe H O H Ga
CH2CO2Et H SMe H O H Ga
CH2CO2Pr-n H SMe H O H Gb
CH2OCH2CH＝CH2 H SMe H O H Gb
CH2OCH2C≡CH H SMe H O H Gb
CH＝CHCO2Me H SMe H O H Ga
R3 R2 R1 R4 X M Gn
CH＝CHCO2Et H SMe H O H Ga
CH＝CHCO2Pr-n H SMe H O H Gb
CH＝CHCN H SMe H O H Ga
Ph H SMe H O H Ga
CH2Ph H SMe H O H Ga
OPh H SMe H O H Ga
SPh H SMe H O H Ga
SO2Ph H SMe H O H Ga
CONHMe H SMe H O H Ga
CONHEt H SMe H O H Ga
CON(Me)2 H SMe H O H Ga
CON(Et)2 H SMe H O H Ga
F H SO2Me H O H Ga
Cl H SO2Me H O H Ga
Br H SO2Me H O H Ga
I H SO2Me H O H Ga
CH＝CH2 H SO2Me H O H Ga
CH2CH＝CH2 H SO2Me H O H Ga
C≡CH H SO2Me H O H Ga
CH2C≡CH H SO2Me H O H Ga
CH2F H SO2Me H O H Ga
CHF2 H SO2Me H O H Ga
CN H SO2Me H O H Ga
NH2 H SO2Me H O H Ga
NHCOMe H SO2Me H O H Ga
CH2NH2 H SO2Me H O H Ga
CH2NHCOMe H SO2Me H O H Ga
CH2OCHF2 H SO2Me H O H Ga
CF3 H SO2Me H O H Ga
NO2 H SO2Me H O H Gb
OMe H SO2Me H O H Ga
OEt H SO2Me H O H Ga
OPr-n H SO2Me H O H Gb
SMe H SO2Me H O H Ga
SEt H SO2Me H O H Ga
SO2Me H SO2Me H O H Ga
SO2Et H SO2Me H O H Ga
COMe H SO2Me H O H Ga
COEt H SO2Me H O H Ga
CO2H H SO2Me H O H Gb
R3 R2 R1 R4 X M Gn
CO2Me H SO2Me H O H Ga
CO2Et H SO2Me H O H Ga
CO2Pr-n H SO2Me H O H Gb
CO2Bu-n H SO2Me H O H Gc
CH2Cl H SO2Me H O H Ga
CH2Br H SO2Me H O H Gb
CH2I H SO2Me H O H Gb
CH2CF3 H SO2Me H O H Ga
CH2CN H SO2Me H O H Ga
CH2OH H SO2Me H O H Gb
CH2OMe H SO2Me H O H Ga
CH2OEt H SO2Me H O H Ga
CH2OPr-n H SO2Me H O H Gb
CH2SMe H SO2Me H O H Ga
CH2SEt H SO2Me H O H Ga
CH2SPr-n H SO2Me H O H Gb
CH2SO2Me H SO2Me H O H Ga
CH2SO2Et H SO2Me H O H Ga
CH2COMe H SO2Me H O H Ga
CH2COEt H SO2Me H O H Ga
CH2COPr-n H SO2Me H O H Gb
CH2CO2H H SO2Me H O H Gb
CH2CO2Me H SO2Me H O H Ga
CH2CO2Et H SO2Me H O H Ga
CH2CO2Pr-n H SO2Me H O H Gb
CH2OCH2CH＝CH2 H SO2Me H O H Gb
GH2OCH2C≡CH H SO2Me H O H Gb
CH＝CHO2Me H SO2Me H O H Ga
CH＝CHCO2Et H SO2Me H O H Ga
CH＝CHCO2Pr-n H SO2Me H O H Gb
CH＝CHCN H SO2Me H O H Ga
Ph H SO2Me H O H Ga
CH2Ph H SO2Me H O H Ga
OPh H SO2Me H O H Ga
SPh H SO2Me H O H Ga
SO2Ph H SO2Me H O H Ga
CONHMe H SO2Me H O H Ga
CONHEt H SO2Me H O H Ga
CON(Me)2 H SO2Me H O H Ga
CON(Et)2 H SO2Me H O H Ga
R3 R2 R1 R4 X M Gn
F H COMe H O H Ga
Cl H COMe H O H Ga
Br H COMe H O H Ga
I H COMe H O H Ga
CH＝CH2 H COMe H O H Ga
CH2CH＝CH2 H COMe H O H Ga
C≡CH H COMe H O H Ga
CH2C≡CH H COMe H O H Ga
CH2F H COMe H O H Ga
CHF2 H COMe H O H Ga
CN H COMe H O H Ga
NH2 H COMe H O H Ga
NHCOMe H COMe H O H Ga
CH2NH2 H COMe H O H Ga
CH2NHCOMe H COMe H O H Ga
CH2OCHF2 H COMe H O H Ga
CF3 H COMe H O H Ga
NO2 H COMe H O H Gb
OMe H COMe H O H Ga
OEt H COMe H O H Ga
OPr-n H COMe H O H Gb
SMe H COMe H O H Ga
SEt H COMe H O H Ga
SO2Me H COMe H O H Ga
SO2Et H COMe H O H Ga
COMe H COMe H O H Ga
COEt H COMe H O H Ga
CO2H H COMe H O H Gb
CO2Me H COMe H O H Ga
CO2Et H COMe H O H Ga
CO2Pr-n H COMe H O H Gb
CO2Bu-n H COMe H O H Gc
CH2Cl H COMe H O H Ga
CH2Br H COMe H O H Gb
CH2I H COMe H O H Gb
CH2CF3 H COMe H O H Ga
CH2CN H COMe H O H Ga
CH2OH H COMe H O H Gb
CH2OMe H COMe H O H Ga
CH2OEt H COMe H O H Ga
R3 R2 R1 R4 X M Gn
CH2OPr-n H COMe H O H Gb
CH2SMe H COMe H O H Ga
CH2SEt H COMe H O H Ga
CH2SPr-n H COMe H O H Gb
CH2SO2Me H COMe H O H Ga
CH2SO2Et H COMe H O H Ga
CH2COMe H COMe H O H Ga
CH2COEt H COMe H O H Ga
CH2COPr-n H COMe H O H Gb
CH2CO2H H COMe H O H Gb
CH2CO2Me H COMe H O H Ga
CH2CO2Et H COMe H O H Ga
CH2CO2Pr-n H COMe H O H Gb
CH2OCH2CH＝CH2 H COMe H O H Gb
CH2OCH2C≡CH H COMe H O H Gb
CH＝CHCO2Me H COMe H O H Ga
CH＝CHCO2Et H COMe H O H Ga
CH＝CHCO2Pr-n H COMe H O H Gb
CH＝CHCN H COMe H O H Ga
Ph H COMe H O H Ga
CH2Ph H COMe H O H Ga
OPh H COMe H O H Ga
SPh H COMe H O H Ga
SO2Ph H COMe H O H Ga
CONHMe H COMe H O H Ga
CONHEt H COMe H O H Ga
CON(Me)2 H COMe H O H Ga
CON(Et)2 H COMe H O H Ga
F H CO2Me H O H Ga
Cl H CO2Me H O H Ga
Br H CO2Me H O H Ga
I H CO2Me H O H Ga
CH＝CH2 H CO2Me H O H Ga
CH2CH＝CH2 H CO2Me H O H Ga
C≡CH H CO2Me H O H Ga
CH2C≡CH H CO2Me H O H Ga
CH2F H CO2Me H O H Ga
CHF2 H CO2Me H O H Ga
CN H CO2Me H O H Ga
NH2 H CO2Me H O H Ga
R3 R2 R1 R4 X M Gn
NHCOMe H CO2Me H O H Ga
CH2NH2 H CO2Me H O H Ga
CH2NHCOMe H CO2Me H O H Ga
CH2OCHF2 H CO2Me H O H Ga
CF3 H CO2Me H O H Ga
NO2 H CO2Me H O H Gb
OMe H CO2Me H O H Ga
OEt H CO2Me H O H Ga
OPr-n H CO2Me H O H Gb
SMe H CO2Me H O H Ga
SEt H CO2Me H O H Ga
SO2Me H CO2Me H O H Ga
SO2Et H CO2Me H O H Ga
COMe H CO2Me H O H Ga
COEt H CO2Me H O H Ga
CO2H H CO2Me H O H Gb
CO2Me H CO2Me H O H Ga
CO2Et H CO2Me H O H Ga
CO2Pr-n H CO2Me H O H Gb
CO2Bu-n H CO2Me H O H Gc
CH2Cl H CO2Me H O H Ga
CH2Br H CO2Me H O H Gb
CH2I H CO2Me H O H Gb
CH2CF3 H CO2Me H O H Ga
CH2CN H CO2Me H O H Ga
CH2OH H CO2Me H O H Gb
CH2OMe H CO2Me H O H Ga
CH2OEt H CO2Me H O H Ga
CH2OPr-n H CO2Me H O H Gb
CH2SMe H CO2Me H O H Ga
CH2SEt H CO2Me H O H Ga
CH2SPr-n H CO2Me H O H Gb
CH2SO2Me H CO2Me H O H Ga
CH2SO2Et H CO2Me H O H Ga
CH2COMe H CO2Me H O H Ga
CH2COEt H CO2Me H O H Ga
CH2COPr-n H CO2Me H O H Gb
CH2CO2H H CO2Me H O H Gb
CH2CO2Me H CO2Me H O H Ga
CH2CO2Et H CO2Me H O H Ga
R3 R2 R1 R4 X M Gn
CH2CO2Pr-n H CO2Me H O H Gb
CH2OCH2CH＝CH2 H CO2Me H O H Gb
CH2OCH2C≡CH H CO2Me H O H Gb
CH＝CHCO2Me H CO2Me H O H Ga
CH＝CHCO2Et H CO2Me H O H Ga
CH＝CHCO2Pr-n H CO2Me H O H Gb
CH＝CHCN H CO2Me H O H Ga
Ph H CO2Me H O H Ga
CH2Ph H CO2Me H O H Ga
OPh H CO2Me H O H Ga
SPh H CO2Me H O H Ga
SO2Ph H CO2Me H O H Ga
CONHMe H CO2Me H O H Ga
CONHEt H CO2Me H O H Ga
CON(Me)2 H CO2Me H O H Ga
CON(Et)2 H CO2Me H O H Ga
F H CO2H H O H Ga
Cl H CO2H H O H Ga
Br H CO2H H O H Ga
I H CO2H H O H Ga
CH＝CH2 H CO2H H O H Ga
CH2CH＝CH2 H CO2H H O H Ga
C≡CH H CO2H H O H Ga
CH2C≡CH H CO2H H O H Ga
CH2F H CO2H H O H Ga
CHF2 H CO2H H O H Ga
CN H CO2H H O H Ga
NH2 H CO2H H O H Ga
NHCOMe H CO2H H O H Ga
CH2NH2 H CO2H H O H Ga
CH2NHCOMe H CO2H H O H Ga
CH2OCHF2 H CO2H H O H Ga
CF3 H CO2H H O H Ga
NO2 H CO2H H O H Gb
OMe H CO2H H O H Ga
OEt H CO2H H O H Ga
OPr-n H CO2H H O H Gb
SMe H CO2H H O H Ca
SEt H CO2H H O H Ga
SO2Me H CO2H H O H Ga
R3 R2 R1 R4 X M Gn
SO2Et H CO2H H O H Ga
COMe H CO2H H O H Ga
COEt H CO2H H O H Ga
CO2H H CO2H H O H Gb
CO2Me H CO2H H O H Ga
CO2Et H CO2H H O H Ga
CO2Pr-n H CO2H H O H Gb
CO2Bu-n H CO2H H O H Gc
CH2Cl H CO2H H O H Ga
CH2Br H CO2H H O H Gb
CH2I H CO2H H O H Gb
CH2CF3 H CO2H H O H Ga
CH2CN H CO2H H O H Ga
CH2OH H CO2H H O H Gb
CH2OMe H CO2H H O H Ga
CH2OEt H CO2H H O H Ga
CH2OPr-n H CO2H H O H Gb
CH2SMe H CO2H H O H Ga
CH2SEt H CO2H H O H Ga
CH2SPr-n H CO2H H O H Gb
CH2SO2Me H CO2H H O H Ga
CH2SO2Et H CO2H H O H Ga
CH2COMe H CO2H H O H Ga
CH2COEt H CO2H H O H Ga
CH2COPr-n H CO2H H O H Gb
CH2CO2H H CO2H H O H Gb
CH2CO2Me H CO2H H O H Ga
CH2CO2Et H CO2H H O H Ga
CH2CO2Pr-n H CO2H H O H Gb
CH2OCH2CH＝CH2 H CO2H H O H Gb
CH2OCH2C≡CH H CO2H H O H Gb
CH＝CHCO2Me H CO2H H O H Ga
CH＝CHCO2Et H CO2H H O H Ga
CH＝CHCO2Pr-n H CO2H H O H Gb
CH＝CHCN H CO2H H O H Ga
Ph H CO2H H O H Ga
CH2Ph H CO2H H O H Ga
OPh H CO2H H O H Ga
SPh H CO2H H O H Ga
SO2Ph H CO2H H O H Ga
R3 R2 R1 R4 X M Gn
CONHMe H CO2H H O H Ga
CONHEt H CO2H H O H Ga
CON(Me)2 H CO2H H O H Ga
CON(Et)2 H CO2H H O H Ga
F H CH2F H O H Ga
Cl H CH2F H O H Ga
Br H CH2F H O H Ga
I H CH2F H O H Ga
CH＝CH2 H CH2F H O H Ga
CH2CH＝CH2 H CH2F H O H Ga
C≡CH H CH2F H O H Ga
CH2C≡CH H CH2F H O H Ga
CH2F H CH2F H O H Ga
CHF2 H CH2F H O H Ga
CN H CH2F H O H Ga
NH2 H CH2F H O H Ga
NHCOMe H CH2F H O H Ga
CH2NH2 H CH2F H O H Ga
CH2NHCOMe H CH2F H O H Ga
CH2OCHF2 H CH2F H O H Ga
CF3 H CH2F H O H Ga
NO2 H CH2F H O H Gb
OMe H CH2F H O H Ga
OEt H CH2F H O H Ga
OPr-n H CH2F H O H Gb
SMe H CH2F H O H Ga
SEt H CH2F H O H Ga
SO2Me H CH2F H O H Ga
SO2Et H CH2F H O H Ga
COMe H CH2F H O H Ga
COEt H CH2F H O H Ga
CO2H H CH2F H O H Gb
CO2Me H CH2F H O H Ga
CO2Et H CH2F H O H Ga
CO2Pr-n H CH2F H O H Gb
CO2Bu-n H CH2F H O H Gc
CH2Cl H CH2F H O H Ga
CH2Br H CH2F H O H Gb
CH2I H CH2F H O H Gb
CH2CF3 H CH2F H O H Ga
R3 R2 R1 R4 X M Gn
CH2CN H CH2F H O H Ga
CH2OH H CH2F H O H Gb
CH2OMe H CH2F H O H Ga
CH2OEt H CH2F H O H Ga
CH2OPr-n H CH2F H O H Gb
CH2SMe H CH2F H O H Ga
CH2SEt H CH2F H O H Ga
CH2SPr-n H CH2F H O H Gb
CH2SO2Me H CH2F H O H Ga
CH2SO2Et H CH2F H O H Ga
CH2COMe H CH2F H O H Ga
CH2COEt H CH2F H O H Ga
CH2COPr-n H CH2F H O H Gb
CH2CO2H H CH2F H O H Gb
CH2CO2Me H CH2F H O H Ga
CH2CO2Et H CH2F H O H Ga
CH2CO2Pr-n H CH2F H O H Gb
CH2OCH2CH＝CH2H CH2F H O H Gb
CH2OCH2C≡CH H CH2F H O H Gb
CH＝CHCO2Me H CH2F H O H Ga
CH＝CHCO2Et H CH2F H O H Ga
CH＝CHCO2Pr-n H CH2F H O H Gb
CH＝CHCN H CH2F H O H Ga
Ph H CH2F H O H Ga
CH2Ph H CH2F H O H Ga
OPh H CH2F H O H Ga
SPh H CH2F H O H Ga
SO2Ph H CH2F H O H Ga
CONHMe H CH2F H O H Ga
CONHEt H CH2F H O H Ga
CON(Me)2 H CH2F H O H Ga
CON(Et)2 H CH2F H O H Ga
F H CH2Cl H O H Ga
Cl H CH2Cl H O H Ga
Br H CH2Cl H O H Ga
I H CH2Cl H O H Ga
CH＝CH2 H CH2Cl H O H Ga
CH2CH＝CH2 H CH2Cl H O H Ga
C≡CH H CH2Cl H O H Ga
CH2C≡CH H CH2Cl H O H Ga
R3 R2 R1 R4 X M Gn
CH2F H CH2Cl H O H Ga
CHF2 H CH2Cl H O H Ga
CN H CH2Cl H O H Ga
NH2 H CH2Cl H O H Ga
NHCOMe H CH2Cl H O H Ga
CH2NH2 H CH2Cl H O H Ga
CH2NHCOMe H CH2Cl H O H Ga
CH2OCHF2 H CH2Cl H O H Ga
CF3 H CH2Cl H O H Ga
NO2 H CH2Cl H O H Gb
OMe H CH2Cl H O H Ga
OEt H CH2Cl H O H Ga
OPr-n H CH2Cl H O H Gb
SMe H CH2Cl H O H Ga
SEt H CH2Cl H O H Ga
SO2Me H CH2Cl H O H Ga
SO2Et H CH2Cl H O H Ga
COMe H CH2Cl H O H Ga
COEt H CH2Cl H O H Ga
CO2H H CH2Cl H O H Gb
CO2Me H CH2Cl H O H Ga
CO2Et H CH2Cl H O H Ga
CO2Pr-n H CH2Cl H O H Gb
CO2Bu-n H CH2Cl H O H Gc
CH2Cl H CH2Cl H O H Ga
CH2Br H CH2Cl H O H Gb
CH2I H CH2Cl H O H Gb
CH2CF3 H CH2Cl H O H Ga
CH2CN H CH2Cl H O H Ga
CH2OH H CH2Cl H O H Gb
CH2OMe H CH2Cl H O H Ga
CH2OEt H CH2Cl H O H Ga
CH2OPr-n H CH2Cl H O H Gb
CH2SMe H CH2Cl H O H Ga
CH2SEt H CH2Cl H O H Ga
CH2SPr-n H CH2Cl H O H Gb
CH2SO2Me H CH2Cl H O H Ga
CH2SO2Et H CH2Cl H O H Ga
CH2COMe H CH2Cl H O H Ga
CH2COEt H CH2Cl H O H Ga
R3 R2 R1 R4 X M Gn
CH2COPr-n H CH2Cl H O H Gb
CH2CO2H H CH2Cl H O H Gb
CH2CO2Me H CH2Cl H O H Ga
CH2CO2Et H CH2Cl H O H Ga
CH2CO2Pr-n H CH2Cl H O H Gb
CH2OCH2CH＝CH2H CH2Cl H O H Gb
CH2OCH2C≡CH H CH2Cl H O H Gb
CH＝CHCO2Me H CH2Cl H O H Ga
CH＝CHCO2Et H CH2Cl H O H Ga
CH＝CHCO2Pr-n H CH2Cl H O H Gb
CH＝CHCN H CH2Cl H O H Ga
Ph H CH2Cl H O H Ga
CH2Ph H CH2Cl H O H Ga
OPh H CH2Cl H O H Ga
SPh H CH2Cl H O H Ga
SO2Ph H CH2Cl H O H Ga
CONHMe H CH2Cl H O H Ga
CONHEt H CH2Cl H O H Ga
CON(Me)2 H CH2Cl H O H Ga
CON(Et)2 H CH2Cl H O H Ga
F H CH2OHe H O H Ga
Cl H CH2OMe H O H Ga
Br H CH2OMe H O H Ga
I H CH2OMe H O H Ga
CH＝CH2 H CH2OMe H O H Ga
CH2CH＝CH2 H CH2OMe H O H Ga
C≡CH H CH2OMe H O H Ga
CH2C≡CH H CH2OMe H O H Ga
CH2F H CH2OMe H O H Ga
CHF2 H CH2OMe H O H Ga
CN H CH2OHe H O H Ga
NH2 H CH2OMe H O H Ga
NHCOMe H CH2OMe H O H Ga
CH2NH2 H CH2OMe H O H Ga
CH2NHCOMe H CH2OMe H O H Ga
CH2OCHF2 H CH2OMe H O H Ga
CF3 H CH2OMe H O H Ga
NO2 H CH2OMe H O H Gb
OMe H CH2OMe H O H Ga
OEt H CH2OMe H O H Ga
R3 R2 R1 R4 X M Gn
OPr-n H CH2OMe H O H Gb
SMe H CH2OMe H O H Ga
SEt H CH2OMe H O H Ga
SO2Me H CH2OMe H O H Ga
SO2Et H CH2OMe H O H Ga
COMe H CH2OMe H O H Ga
COEt H CH2OMe H O H Ga
CO2H H CH2OMe H O H Gb
CO2Me H CH2OMe H O H Ga
CO2Et H CH2OMe H O H Ga
CO2Pr-n H CH2OMe H O H Gb
CO2Bu-n H CH2OMe H O H Gc
CH2Cl H CH2OMe H O H Ga
CH2Br H CH2OMe H O H Gb
CH2I H CH2OMe H O H Gb
CH2CF3 H CH2OMe H O H Ga
CH2CN H CH2OMe H O H Ga
CH2OH H CH2OMe H O H Gb
CH2OMe H CH2OMe H O H Ga
CH2OEt H CH2OMe H O H Ga
CH2OPr-n H CH2OMe H O H Gb
CH2SMe H CH2OMe H O H Ga
CH2SEt H CH2OMe H O H Ga
CH2SPr-n H CH2OMe H O H Gb
CH2SO2Me H CH2OMe H O H Ga
CH2SO2Et H CH2OMe H O H Ga
CH2COMe H CH2OMe H O H Ga
CH2COEt H CH2OMe H O H Ga
CH2COPr-n H CH2OMe H O H Gb
CH2CO2H H CH2OMe H O H Gb
CH2CO2Me H CH2OMe H O H Ga
CH2CO2Et H CH2OMe H O H Ga
CH2CO2Pr-n H CH2OMe H O H Gb
CH2OCH2CH＝CH2 H CH2OMe H O H Gb
CH2OCH2C≡CH H CH2OMe H O H Gb
CH＝CHCO2Me H CH2OMe H O H Ga
CH＝CHCO2Et H CH2OMe H O H Ga
CH＝CHCO2Pr-n H CH2OMe H O H Gb
CH＝CHCN H CH2OMe H O H Ga
Ph H CH2OMe H O H Ga
R3 R2 R1 R4 X M Gn
CH2Ph H CH2OMe H O H Ga
OPh H CH2OMe H O H Ga
SPh H CH2OMe H O H Ga
SO2Ph H CH2OMe H O H Ga
CONHMe H CH2OMe H O H Ga
CONHEt H CH2OMe H O H Ga
CON(Me)2 H CH2OMe H O H Ga
CON(Et)2 H CH2OMe H O H Ga
F H CH2SMe H O H Ga
Cl H CH2SMe H O H Ga
Br H CH2SMe H O H Ga
I H CH2SMe H O H Ga
CH＝CH2 H CH2SMe H O H Ga
CH2CH＝CH2 H CH2SMe H O H Ga
C≡CH H CH2SMe H O H Ga
CH2C≡CH H CH2SMe H O H Ga
CH2F H CH2SMe H O H Ga
CHF2 H CH2SMe H O H Ga
CN H CH2SMe H O H Ga
NH2 H CH2SMe H O H Ga
NHCOMe H CH2SMe H O H Ga
CH2NH2 H CH2SMe H O H Ga
CH2NHCOMe H CH2SMe H O H Ga
CH2OCHF2 H CH2SMe H O H Ga
CF3 H CH2SMe H O H Ga
NO2 H CH2SMe H O H Gb
OMe H CH2SMe H O H Ga
OEt H CH2SMe H O H Ga
OPr-n H CH2SMe H O H Gb
SMe H CH2SMe H O H Ga
SEt H CH2SMe H O H Ga
SO2Me H CH2SMe H O H Ga
SO2Et H CH2SMe H O H Ga
COMe H CH2SMe H O H Ga
COEt H CH2SMe H O H Ga
CO2H H CH2SMe H O H Gb
CO2Me H CH2SMe H O H Ga
CO2Et H CH2SMe H O H Ga
CO2Pr-n H CH2SMe H O H Gb
CO2Bu-n H CH2SMe H O H Gc
R3 R2 R1 R4 X M Gn
CH2Cl H CH2SMe H O H Ga
CH2Br H CH2SMe H O H Gb
CH2I H CH2SMe H O H Gb
CH2CF3 H CH2SMe H O H Ga
CH2CN H CH2SMe H O H Ga
CH2OH H CH2SMe H O H Gb
CH2OMe H CH2SMe H O H Ga
CH2OEt H CH2SMe H O H Ga
CH2OPr-n H CH2SMe H O H Gb
CH2SMe H CH2SMe H O H Ga
CH2SEt H CH2SMe H O H Ga
CH2SPr-n H CH2SMe H O H Gb
CH2SO2Me H CH2SMe H O H Ga
CH2SO2Et H CH2SMe H O H Ga
CH2COMe H CH2SMe H O H Ga
CH2COEt H CH2SMe H O H Ga
CH2COPr-n H CH2SMe H O H Gb
CH2CO2H H CH2SMe H O H Gb
CH2CO2Me H CH2SMe H O H Ga
CH2CO2Et H CH2SMe H O H Ga
CH2CO2Pr-n H CH2SMe H O H Gb
CH2OCH2CH＝CH2H CH2SMe H O H Gb
CH2OCH2C≡CH H CH2SMe H O H Cb
CH＝CHCO2Me H CH2SMe H O H Ga
CH＝CHCO2Et H CH2SMe H O H Ga
CH＝CHCO2Pr-n H CH2SMe H O H Gb
CH＝CHCN H CH2SMe H O H Ga
Ph H CH2SMe H O H Ga
CH2Ph H CH2SMe H O H Ga
OPh H CH2SMe H O H Ga
SPh H CH2SMe H O H Ga
SO2Ph H CH2SMe H O H Ga
CONHMe H CH2SMe H O H Ga
CONHEt H CH2SMe H O H Ga
CON(Me)2 H CH2SMe H O H Ga
CON(Et)2 H CH2SMe H O H Ga
F H CH2SO2Me H O H Ga
Cl H CH2SO2Me H O H Ga
Br H CH2SO2Me H O H Ga
I H CH2SO2Me H O H Ga
R3 R2 R1 R4 X M Gn
CH＝CH2 H CH2SO2Me H O H Ga
CH2CH＝CH2 H CH2SO2Me H O H Ga
C≡CH H CH2SO2Me H O H Ga
CH2C≡CH H CH2SO2Me H O H Ga
CH2F H CH2SO2Me H O H Ga
CHF2 H CH2SO2Me H O H Ga
CN H CH2SO2Me H O H Ga
NH2 H GH2SO2Me H O H Ga
NHCOMe H CH2SO2Me H O H Ga
CH2NH2 H CH2SO2Me H O H Ga
CH2NHCOMe H CH2SO2Me H O H Ga
CH2OCHF2 H CH2SO2Me H O H Ga
CF3 H CH2SO2Me H O H Ga
NO2 H CH2SO2Me H O H Gb
OMe H CH2SO2Me H O H Ga
OEt H CH2SO2Me H O H Ga
OPr-n H CH2SO2Me H O H Gb
SMe H CH2SO2Me H O H Ga
SEt H CH2SO2Me H O H Ga
SO2Me H CH2SO2Me H O H Ga
SO2Et H CH2SO2Me H O H Ga
COMe H CH2SO2Me H O H Ga
COEt H CH2SO2Me H O H Ga
CO2H H CH2SO2Me H O H Gb
CO2Me H CH2SO2Me H O H Ga
CO2Et H CH2SO2Me H O H Ga
CO2Pr-n H CH2SO2Me H O H Gb
CO2Bu-n H CH2SO2Me H O H Gc
CH2Cl H CH2SO2Me H O H Ga
CH2Br H CH2SO2Me H O H Gb
CH2I H CH2SO2Me H O H Gb
CH2CF3 H CH2SO2Me H O H Ga
CH2CN H CH2SO2Me H O H Ga
CH2OH H CH2SO2Me H O H Gb
CH2OMe H CH2SO2Me H O H Ga
CH2OEt H CH2SO2Me H O H Ga
CH2OPr-n H CH2SO2Me H O H Gb
CH2SMe H CH2SO2Me H O H Ga
CH2SEt H CH2SO2Me H O H Ga
CH2SPr-n H CH2SO2Me H O H Gb
R3 R2 R1 R4 X M Gn
CH2SO2Me H CH2SO2Me H O H Ga
CH2SO2Et H CH2SO2Me H O H Ga
CH2COMe H CH2SO2Me H O H Ga
CH2COEt H CH2SO2Me H O H Ga
CH2COPr-n H CH2SO2Me H O H Gb
CH2CO2H H CH2SO2Me H O H Gb
CH2CO2Me H CH2SO2Me H O H Ga
CH2CO2Et H CH2SO2Me H O H Ga
CH2CO2Pr-n H CH2SO2Me H O H Gb
CH2OCH2CH＝CH2 H CH2SO2Me H O H Gb
CH2OCH2C≡CH H CH2SO2Me H O H Gb
CH＝CHCO2Me H CH2SO2Me H O H Ga
CH＝CHCO2Et H CH2SO2Me H O H Ga
CH＝CHCO2Pr-n H CH2SO2Me H O H Gb
CH＝CHCN H CH2SO2Me H O H Ga
Ph H CH2SO2Me H O H Ga
CH2Ph H CH2SO2Me H O H Ga
OPh H CH2SO2Me H O H Ga
SPh H CH2SO2Me H O H Ga
SO2Ph H CH2SO2Me H O H Ga
CONHMe H CH2SO2Me H O H Ga
CONHEt H CH2SO2Me H O H Ga
CON(Me)2 H CH2SO2Me H O H Ga
CON(Et)2 H CH2SO2Me H O H Ga
F H Ph H O H Ga
Cl H Ph H O H Ga
Br H Ph H O H Ga
I H Ph H O H Ga
CH＝CH2 H Ph H O H Ga
CH2CH＝CH2 H Ph H O H Ga
C≡CH H Ph H O H Ga
CH2C≡CH H Ph H O H Ga
CH2F H Ph H O H Ga
CHF2 H Ph H O H Ga
CN H Ph H O H Ga
NH2 H Ph H O H Ga
NHCOMe H Ph H O H Ga
CH2NH2 H Ph H O H Ga
CH2NHCOMe H Ph H O H Ga
CH2OCHF2 H Ph H O H Ga
R3 R2 R1 R4 X M Gn
CF3 H Ph H O H Ga
NO2 H Ph H O H Gb
OMe H Ph H O H Ga
OEt H Ph H O H Ga
OPr-n H Ph H O H Gb
SMe H Ph H O H Ga
SEt H Ph H O H Ga
SO2Me H Ph H O H Ga
SO2Et H Ph H O H Ga
COMe H Ph H O H Ga
COEt H Ph H O H Ga
CO2H H Ph H O H Gb
CO2Me H Ph H O H Ga
CO2Et H Ph H O H Ga
CO2Pr-n H Ph H O H Gb
CO2Bu-n H Ph H O H Gc
CH2Cl H Ph H O H Ga
CH2Br H Ph H O H Gb
CH2I H Ph H O H Gb
CH2CF3 H Ph H O H Ga
CH2CN H Ph H O H Ga
CH2OH H Ph H O H Gb
CH2OMe H Ph H O H Ga
CH2OEt H Ph H O H Ga
CH2OPr-n H Ph H O H Gb
CH2SMe H Ph H O H Ga
CH2SEt H Ph H O H Ga
CH2SPr-n H Ph H O H Gb
CH2SO2Me H Ph H O H Ga
CH2SO2Et H Ph H O H Ga
CH2COMe H Ph H O H Ga
CH2COEt H Ph H O H Ga
CH2COPr-n H Ph H O H Gb
CH2CO2H H Ph H O H Gb
CH2CO2Me H Ph H O H Ga
CH2CO2Et H Ph H O H Ga
CH2CO2Pr-n H Ph H O H Gb
CH2OCH2CH＝CH2 H Ph H O H Gb
CH2OCH2C≡CH H Ph H O H Gb
CH＝CHCO2Me H Ph H O H Ga
R3 R2 R1 R4 X M Gn
CH＝CHCO2Et H Ph H O H Ga
CH＝CHCO2Pr-n H Ph H O H Gb
CH＝CHCN H Ph H O H Ga
Ph H Ph H O H Ga
CH2Ph H Ph H O H Ga
OPh H Ph H O H Ga
SPh H Ph H O H Ga
SO2Ph H Ph H O H Ga
CONHMe H Ph H O H Ga
CONHEt H Ph H O H Ga
CON(Me)2 H Ph H O H Ga
CON(Et)2 H Ph H O H Ga
F H CH2Ph H O H Ga
Cl H CH2Ph H O H Ga
Br H CH2Ph H O H Ga
I H CH2Ph H O H Ga
CH＝CH2 H CH2Ph H O H Ga
CH2CH＝CH2 H CH2Ph H O H Ga
C≡CH H CH2Ph H O H Ga
CH2C≡CH H CH2Ph H O H Ga
CH2F H CH2Ph H O H Ga
CHF2 H CH2Ph H O H Ga
CN H CH2Ph H O H Ga
NH2 H CH2Ph H O H Ga
NHCOMe H CH2Ph H O H Ga
CH2NH2 H CH2Ph H O H Ga
CH2NHCOMe H CH2Ph H O H Ga
CH2OCHF2 H CH2Ph H O H Ga
CF3 H CH2Ph H O H Ga
NO2 H CH2Ph H O H Gb
OMe H CH2Ph H O H Ga
OEt H CH2Ph H O H Ga
OPr-n H CH2Ph H O H Gb
SMe H CH2Ph H O H Ga
SEt H CH2Ph H O H Ga
SO2Me H CH2Ph H O H Ga
SO2Et H CH2Ph H O H Ga
COMe H CH2Ph H O H Ga
COEt H CH2Ph H O H Ga
CO2H H CH2Ph H O H Gb
R3 R2 R1 R4 X M Gn
CO2Me H CH2Ph H O H Ga
CO2Et H CH2Ph H O H Ga
CO2Pr-n H CH2Ph H O H Gb
CO2Bu-n H CH2Ph H O H Gc
CH2Cl H CH2Ph H O H Ga
CH2Br H CH2Ph H O H Gb
CH2I H CH2Ph H O H Gb
CH2CF3 H CH2Ph H O H Ga
CH2CN H CH2Ph H O H Ga
CH2OH H CH2Ph H O H Gb
CH2OMe H CH2Ph H O H Ga
CH2OEt H CH2Ph H O H Ga
CH2OPr-n H CH2Ph H O H Gb
CH2SMe H CH2Ph H O H Ga
CH2SEt H CH2Ph H O H Ga
CH2SPr-n H CH2Ph H O H Gb
CH2SO2Me H CH2Ph H O H Ga
CH2SO2Et H CH2Ph H O H Ga
CH2COMe H CH2Ph H O H Ga
CH2COEt H CH2Ph H O H Ga
CH2COPr-n H CH2Ph H O H Gb
CH2CO2H H CH2Ph H O H Gb
CH2CO2Me H CH2Ph H O H Ga
CH2CO2Et H CH2Ph H O H Ga
CH2CO2Pr-n H CH2Ph H O H Gb
CH2OCH2CH＝CH2H CH2Ph H O H Gb
CH2OCH2C≡CH H CH2Ph H O H Gb
CH＝CHCO2Me H CH2Ph H O H Ga
CH＝CHCO2Et H CH2Ph H O H Ga
CH＝CHCO2Pr-n H CH2Ph H O H Gb
CH＝CHCN H CH2Ph H O H Ga
Ph H CH2Ph H O H Ga
CH2Ph H CH2Ph H O H Ga
OPh H CH2Ph H O H Ga
SPh H CH2Ph H O H Ga
SO2Ph H CH2Ph H O H Ga
CONHMe H CH2Ph H O H Ga
CONHEt H CH2Ph H O H Ga
CON(Me)2 H CH2Ph H O H Ga
CON(Et)2 H CH2Ph H O H Ga
R3 R2 R1 R4 X M Gn
F H OPh H O H Ga
Cl H OPh H O H Ga
Br H OPh H O H Ga
I H OPh H O H Ga
CH＝CH2 H OPh H O H Ga
CH2CH＝CH2 H OPh H O H Ga
C≡CH H OPh H O H Ga
CH2C≡CH H OPh H O H Ga
CH2F H OPh H O H Ga
CHF2 H OPh H O H Ga
CN H OPh H O H Ga
NH2 H OPh H O H Ga
NHCOMe H OPh H O H Ga
CH2NH2 H OPh H O H Ga
CH2NHCOMe H OPh H O H Ga
CH2OCHF2 H OPh H O H Ga
CF3 H OPh H O H Ga
NO2 H OPh H O H Gb
OMe H OPh H O H Ga
OEt H OPh H O H Ga
OPr-n H OPh H O H Gb
SMe H OPh H O H Ga
SEt H OPh H O H Ga
SO2Me H OPh H O H Ga
SO2Et H OPh H O H Ga
COMe H OPh H O H Ga
COEt H OPh H O H Ga
CO2H H OPh H O H Gb
CO2Me H OPh H O H Ga
CO2Et H OPh H O H Ga
CO2Pr-n H OPh H O H Gb
CO2Bu-n H OPh H O H Gc
CH2Cl H OPh H O H Ga
CH2Br H OPh H O H Gb
CH2I H OPh H O H Gb
CH2CF3 H OPh H O H Ga
CH2CN H OPh H O H Ga
CH2OH H OPh H O H Gb
CH2OMe H OPh H O H Ga
CH2OEt H OPh H O H Ga
R3 R2 R1 R4 X M Gn
CH2OPr-n H OPh H O H Gb
CH2SMe H OPh H O H Ga
CH2SEt H OPh H O H Ga
CH2SPr-n H OPh H O H Gb
CH2SO2Me H OPh H O H Ga
CH2SO2Et H OPh H O H Ga
CH2COMe H OPh H O H Ga
CH2COEt H OPh H O H Ga
CH2COPr-n H OPh H O H Gb
CH2CO2H H OPh H O H Gb
CH2CO2Me H OPh H O H Ga
CH2CO2Et H OPh H O H Ga
CH2CO2Pr-n H OPh H O H Gh
CH2OCH2CH＝CH2H OPh H O H Gb
CH2OCH2C≡CH H OPh H O H Gb
CH＝CHCO2Me H OPh H O H Ga
CH＝CHCO2Et H OPh H O H Ga
CH＝CHCO2Pr-n H OPh H O H Gb
CH＝CHCN H OPh H O H Ga
Ph H OPh H O H Ga
CH2Ph H OPh H O H Ga
OPh H OPh H O H Ga
SPh H OPh H O H Ga
SO2Ph H OPh H O H Ga
CONHMe H OPh H O H Ga
CONHEt H OPh H O H Ga
CON(Me)2 H OPh H O H Ga
CON(Et)2 H OPh H O H Ga
F H SPh H O H Ga
Cl H SPh H O H Ga
Br H SPh H O H Ga
I H SPh H O H Ga
CH＝CH2 H SPh H O H Ga
CH2CH＝CH2 H SPh H O H Ga
C≡CH H SPh H O H Ga
CH2C≡CH H SPh H O H Ga
CH2F H SPh H O H Ga
CHF2 H SPh H O H Ga
CN H SPh H O H Ga
NH2 H SPh H O H Ga
R3 R2 R1 R4 X M Gn
NHCOMe H SPh H O H Ga
CH2NH2 H SPh H O H Ga
CH2NHCOMe H SPh H O H Ga
CH2OCHF2 H SPh H O H Ga
CF3 H SPh H O H Ga
NO2 H SPh H O H Gb
OMe H SPh H O H Ga
OEt H SPh H O H Ga
OPr-n H SPh H O H Gb
SMe H SPh H O H Ga
SEt H SPh H O H Ga
SO2Me H SPh H O H Ga
SO2Et H SPh H O H Ga
COMe H SPh H O H Ga
COEt H SPh H O H Ga
CO2H H SPh H O H Gb
CO2Me H SPh H O H Ga
CO2Et H SPh H O H Ga
CO2Pr-n H SPh H O H Gb
CO2Bu-n H SPh H O H Gc
CH2Cl H SPh H O H Ga
CH2Br H SPh H O H Gb
CH2I H SPh H O H Gb
CH2CF3 H SPh H O H Ga
CH2CN H SPh H O H Ga
CH2OH H SPh H O H Gb
CH2OMe H SPh H O H Ga
CH2OEt H SPh H O H Ga
CH2OPr-n H SPh H O H Gb
CH2SMe H SPh H O H Ga
CH2SEt H SPh H O H Ga
CH2SPr-n H SPh H O H Gb
CH2SO2Me H SPh H O H Ga
CH2SO2Et H SPh H O H Ga
CH2COMe H SPh H O H Ga
CH2COEt H SPh H O H Ga
CH2COPr-n H SPh H O H Gb
CH2CO2H H SPh H O H Gb
CH2CO2Me H SPh H O H Ga
CH2CO2Et H SPh H O H Ga
R3 R2 R1 R4 X M Gn
CH2CO2Pr-n H SPh H O H Gb
CH2OCH2CH＝CH2H SPh H O H Gb
CH2OCH2C≡CH H SPh H O H Gb
CH＝CHCO2Me H SPh H O H Ga
CH＝CHCO2Et H SPh H O H Ga
CH＝CHCO2Pr-n H SPh H O H Gb
CH＝CHCN H SPh H O H Ga
Ph H SPh H O H Ga
CH2Ph H SPh H O H Ga
OPh H SPh H O H Ga
SPh H SPh H O H Ga
SO2Ph H SPh H O H Ga
CONHMe H SPh H O H Ga
CONHEt H SPh H O H Ga
CON(Me)2 H SPh H O H Ga
CON(Et)2 H SPh H O H Ga
F H SO2Ph H O H Ga
Cl H SO2Ph H O H Ga
Br H SO2Ph H O H Ga
I H SO2Ph H O H Ga
CH＝CH2 H SO2Ph H O H Ga
CH2CH＝CH2 H SO2Ph H O H Ga
C≡CH H SO2Ph H O H Ga
CH2C≡CH H SO2Ph H O H Ga
CH2F H SO2Ph H O H Ga
CHF2 H SO2Ph H O H Ga
CN H SO2Ph H O H Ga
NH2 H SO2Ph H O H Ga
NHCOMe H SO2Ph H O H Ga
CH2NH2 H SO2Ph H O H Ga
CH2NHCOMe H SO2Ph H O H Ga
CH2OCHF2 H SO2Ph H O H Ga
CF3 H SO2Ph H O H Ga
NO2 H SO2Ph H O H Gb
OMe H SO2Ph H O H Ga
OEt H SO2Ph H O H Ga
OPr-n H SO2Ph H O H Gb
SMe H SO2Ph H O H Ga
SEt H SO2Ph H O H Ga
SO2Me H SO2Ph H O H Ga
R3 R2 R1 R4 X M Gn
SO2Et H SO2Ph H O H Ga
COMe H SO2Ph H O H Ga
COEt H SO2Ph H O H Ga
CO2H H SO2Ph H O H Gb
CO2Me H SO2Ph H O H Ga
CO2Et H SO2Ph H O H Ga
CO2Pr-n H SO2Ph H O H Gb
CO2Bu-n H SO2Ph H O H Gc
CH2Cl H SO2Ph H O H Ga
CH2Br H SO2Ph H O H Gb
CH2I H SO2Ph H O H Gb
CH2CF3 H SO2Ph H O H Ga
CH2CN H SO2Ph H O H Ga
CH2OH H SO2Ph H O H Gb
CH2OMe H SO2Ph H O H Ga
CH2OEt H SO2Ph H O H Ga
CH2OPr-n H SO2Ph H O H Gb
CH2SMe H SO2Ph H O H Ga
CH2SEt H SO2Ph H O H Ga
CH2SPr-n H SO2Ph H O H Gb
CH2SO2Me H SO2Ph H O H Ga
CH2SO2Et H SO2Ph H O H Ga
CH2COMe H SO2Ph H O H Ga
CH2COEt H SO2Ph H O H Ga
CH2COPr-n H SO2Ph H O H Gb
CH2CO2H H SO2Ph H O H Gb
CH2CO2Me H SO2Ph H O H Ga
CH2CO2Et H SO2Ph H O H Ga
CH2CO2Pr-n H SO2Ph H O H Gb
CH2OCH2CH＝CH2 H SO2Ph H O H Gb
CH2OCH2C≡CH H SO2Ph H O H Gb
CH＝CHCO2Me H SO2Ph H O H Ga
CH＝CHCO2Et H SO2Ph H O H Ga
CH＝CHCO2Pr-n H SO2Ph H O H Gb
CH＝CHCN H SO2Ph H O H Ga
Ph H SO2Ph H O H Ga
CH2Ph H SO2Ph H O H Ga
OPh H SO2Ph H O H Ga
SPh H SO2Ph H O H Ga
SO2Ph H SO2Ph H O H Ga
R3 R2 R1 R4 X M Gn
CONHMe H SO2Ph H O H Ga
CONHEt H SO2Ph H O H Ga
CON(Me)2 H SO2Ph H O H Ga
CON(Et)2 H SO2Ph H O H Ga
F H CON(Et)2 H O H Ga
Cl H CON(Et)2 H O H Ga
Br H CON(Et)2 H O H Ga
I H CON(Et)2 H O H Ga
CH＝CH2 H CON(Et)2 H O H Ga
CH2CH＝CH2 H CON(Et)2 H O H Ga
C≡CH H CON(Et)2 H O H Ga
CH2C≡CH H CON(Et)2 H O H Ga
CH2F H CON(Et)2 H O H Ga
CHF2 H CON(Et)2 H O H Ga
CN H CON(Et)2 H O H Ga
NH2 H CON(Et)2 H O H Ga
NHCOMe H CON(Et)2 H O H Ga
CH2NH2 H CON(Et)2 H O H Ga
CH2NHCOMe H CON(Et)2 H O H Ga
CH2OCHF2 H CON(Et)2 H O H Ga
CF3 H CON(Et)2 H O H Ga
NO2 H CON(Et)2 H O H Gb
OMe H CON(Et)2 H O H Ga
OEt H CON(Et)2 H O H Ga
OPr-n H CON(Et)2 H O H Gb
SMe H CON(Et)2 H O H Ga
SEt H CON(Et)2 H O H Ga
SO2Me H CON(Et)2 H O H Ga
SO2Et H CON(Et)2 H O H Ga
COMe H CON(Et)2 H O H Ga
COEt H CON(Et)2 H O H Ga
CO2H H CON(Et)2 H O H Gb
CO2Me H CON(Et)2 H O H Ga
CO2Et H CON(Et)2 H O H Ga
CO2Pr-n H CON(Et)2 H O H Gb
CO2Bu-n H CON(Et)2 H O H Gc
CH2Cl H CON(Et)2 H O H Ga
CH2Br H CON(Et)2 H O H Gb
CH2I H CON(Et)2 H O H Gb
CH2CF3 H CON(Et)2 H O H Ga
R3 R2 R1 R4 X M Gn
CH2CN H CON(Et)2 H O H Ga
CH2OH H CON(Et)2 H O H Gb
CH2OMe H CON(Et)2 H O H Ga
CH2OEt H CON(Et)2 H O H Ga
CH2OPr-n H CON(Et)2 H O H Gb
CH2SMe H CON(Et)2 H O H Ga
CH2SEt H CON(Et)2 H O H Ga
CH2SPr-n H CON(Et)2 H O H Gb
CH2SO2Me H CON(Et)2 H O H Ga
CH2SO2Et H CON(Et)2 H O H Ga
CH2COMe H CON(Et)2 H O H Ga
CH2COEt H CON(Et)2 H O H Ga
CH2COPr-n H CON(Et)2 H O H Gb
CH2CO2H H CON(Et)2 H O H Gb
CH2CO2Me H CON(Et)2 H O H Ga
CH2CO2Et H CON(Et)2 H O H Ga
CH2CO2Pr-n H CON(Et)2 H O H Gb
CH2OCH2CH＝CH2H CON(Et)2 H O H Gb
CH2OCH2C≡CH H CON(Et)2 H O H Gb
CH＝CHCO2Me H CON(Et)2 H O H Ga
CH＝CHCO2Et H CON(Et)2 H O H Ga
CH＝CHCO2Pr-n H CON(Et)2 H O H Gb
CH＝CHCN H CON(Et)2 H O H Ga
Ph H CON(Et)2 H O H Ga
CH2Ph H CON(Et)2 H O H Ga
OPh H CON(Et)2 H O H Ga
SPh H CON(Et)2 H O H Ga
SO2Ph H CON(Et)2 H O H Ga
CONHMe H CON(Et)2 H O H Ga
CONHEt H CON(Et)2 H O H Ga
CON(Me)2 H CON(Et)2 H O H Ga
CON(Et)2 H CON(Et)2 H O H Ga
F H CN H O H Ga
Cl H CN H O H Ga
Br H CN H O H Ga
I H CN H O H Ga
CH＝CH2 H CN H O H Ga
CH2CH＝CH2 H CN H O H Ga
C≡CH H CN H O H Ga
CH2C≡CH H CN H O H Ga
R3 R2 R1 R4 X M Gn
CH2F H CN H O H Ga
CHF2 H CN H O H Ga
CN H CN H O H Ga
NH2 H CN H O H Ga
NHCOMe H CN H O H Ga
CH2NH2 H CN H O H Ga
CH2NHCOMe H CN H O H Ga
CH2OCHF2 H CN H O H Ga
CF3 H CN H O H Ga
NO2 H CN H O H Gb
OMe H CN H O H Ga
OEt H CN H O H Ga
OPr-n H CN H O H Gb
SMe H CN H O H Ga
SEt H CN H O H Ga
SO2Me H CN H O H Ga
SO2Et H CN H O H Ga
COMe H CN H O H Ga
COEt H CN H O H Ga
CO2H H CN H O H Gb
CO2Me H CN H O H Ga
CO2Et H CN H O H Ga
CO2Pr-n H CN H O H Gb
CO2Bu-n H CN H O H Gc
CH2Cl H CN H O H Ga
CH2Br H CN H O H Gb
CH2I H CN H O H Gb
CH2CF3 H CN H O H Ga
CH2CN H CN H O H Ga
CH2OH H CN H O H Gb
CH2OMe H CN H O H Ga
CH2OEt H CN H O H Ga
CH2OPr-n H CN H O H Gb
CH2SMe H CN H O H Ga
CH2SEt H CN H O H Ga
CH2SPr-n H CN H O H Gb
CH2SO2Me H CN H O H Ga
CH2SO2Et H CN H O H Ga
CH2COMe H CN H O H Ga
CH2COEt H CN H O H Ga
R3 R2 R1 R4 X M Gn
CH2COPr-n H CN H O H Gb
CH2CO2H H CN H O H Gb
CH2CO2Me H CN H O H Ga
CH2CO2Et H CN H O H Ga
CH2CO2Pr-n H CN H O H Gb
CH2OCH2CH＝CH2 H CN H O H Gb
CH2OCH2C≡CH H CN H O H Gb
CH＝CHCO2Me H CN H O H Ga
CH＝CHCO2Et H CN H O H Ga
CH＝CHCO2Pr-n H CN H O H Gb
CH＝CHCN H CN H O H Ga
Ph H CN H O H Ga
CH2Ph H CN H O H Ga
OPh H CN H O H Ga
SPh H CN H O H Ga
SO2Ph H CN H O H Ga
CONHMe H CN H O H Ga
CONHEt H CN H O H Ga
CON(Me)2 H CN H O H Ga
CON(Et)2 H CN H O H Ga
F H Et H O H Ga
Cl H Et H O H Ga
Br H Et H O H Ga
I H Et H O H Ga
CH＝CH2 H Et H O H Ga
CH2CH＝CH2 H Et H O H Ga
C≡CH H Et H O H Ga
CH2C≡CH H Et H O H Ga
CH2F H Et H O H Ga
CHF2 H Et H O H Ga
CN H Et H O H Ga
NH2 H Et H O H Ga
NHCOMe H Et H O H Ga
CH2NH2 H Et H O H Ga
CH2NHCOMe H Et H O H Ga
CH2OCHF2 H Et H O H Ga
CF3 H Et H O H Ga
NO2 H Et H O H Gb
OMe H Et H O H Ga
OEt H Et H O H Ga
R3 R2 R1 R4 X M Gn
OPr-n H Et H O H Gb
SMe H Et H O H Ga
SEt H Et H O H Ga
SO2Me H Et H O H Ga
SO2Et H Et H O H Ga
COMe H Et H O H Ga
COEt H Et H O H Ga
CO2H H Et H O H Gb
CO2Me H Et H O H Ga
CO2Et H Et H O H Ga
CO2Pr-n H Et H O H Gb
CO2Bu-n H Et H O H Gc
CH2Cl H Et H O H Ga
CH2Br H Et H O H Gb
CH2I H Et H O H Gb
CH2CF3 H Et H O H Ga
CH2CN H Et H O H Ga
CH2OH H Et H O H Gb
CH2OMe H Et H O H Ga
CH2OEt H Et H O H Ga
CH2OPr-n H Et H O H Gb
CH2SMe H Et H O H Ga
CH2SEt H Et H O H Ga
CH2SPr-n H Et H O H Gb
CH2SO2Me H Et H O H Ga
CH2SO2Et H Et H O H Ga
CH2COMe H Et H O H Ga
CH2COEt H Et H O H Ga
CH2COPr-n H Et H O H Gb
CH2CO2H H Et H O H Gb
CH2CO2Me H Et H O H Ga
CH2CO2Et H Et H O H Ga
CH2CO2Pr-n H Et H O H Gb
CH2OCH2CH＝CH2H Et H O H Gb
CH2OCH2C≡CH H Et H O H Gb
CH＝CHCO2Me H Et H O H Ga
CH＝CHCO2Et H Et H O H Ga
CH＝CHCO2Pr-n H Et H O H Gb
CH＝CHCN H Et H O H Ga
Ph H Et H O H Ga
R3 R2 R1 R4 X M Gn
CH2Ph H Et H O H Ga
OPh H Et H O H Ga
SPh H Et H O H Ga
SO2Ph H Et H O H Ga
CONHMe H Et H O H Ga
CONHEt H Et H O H Ga
CON(Me)2 H Et H O H Ga
CON(Et)2 H Et H O H Ga表8
R1 R2 R3 R4 R5 X M Gn
H H H H H O H Ga
H H H H H S H G3
Me H H H H O H Ga
Me H H H H S H G3
H Me H H H O H Ga
H Me H H H S H G3
H H Me H H O H Ga
H H Me H H S H G3
H H H Me H O H Ga
H H H Me H S H G3
H H H Me H O Me Gb
H H H Me H O Et Gb
H H H Me H O CH2CH＝CH2 Gb
H H H Me H O CH2C≡CH Gb
Et H H H H O H Gb
Et H H H H S H G3
H Et H H H O H Gb
H Et H H H S H G3
H H Et H H O H Gb
H H Et H H S H G3
H H H Et H O H Ga
H H H Et H S H G3
Pr-n H H H H O H Gb
H Pr-n H H H O H Gb
H H Pr-n H H O H Gb
H H H Pr-n H O H Gb
Pr-i H H H H O H Gb
H Pr-i H H H O H Gb
H H Pr-i H H O H Gb
H H H Pr-i H O H Gb
R1 R2 R3 R4 R5 X M Gn
Bu-n H H H H O H Gc
H Bu-n H H H O H Gc
H H Bu-n H H O H Gc
H H H Bu-n H O H Gc
H H H Me Me O H Ga
H H H Me Me S H G3
H H H Me Me O Me Gb
H H H Me Me O Et Gb
H H H Me Me O CH2CH＝CH2Gb
H H H Me Me O CH2C≡CH Gb
Me H H Me Me O H Ga
H Me H Me Me O H Ga
H H Me Me Me O H Ga
Et H H Me Me O H Gb
H Et H Me Me O H Gb
H H Et Me Me O H Gb
Pr-n H H Me Me O H Gb
H Pr-n H Me Me O H Gb
H H Pr-n Me Me O H Gb
Pr-i H H Me Me O H Gb
H Pr-i H Me Me O H Gb
H H Pr-i Me Me O H Gb
Bu-n H H Me Me O H Gc
H Bu-n H Me Me O H Gc
H H Bu-n Me Me O H Gc
Me Me H Me Me O H Gb
Me H Me Me Me O H Gb
H Me Me Me Me O H Gb
Me Me Me Me Me O H Gb
Et Et H Me Me O H Gc
Et H Et Me Me O H Gc
H Et Et Me Me O H Gc
Et Et Et Me Me O H Gc
Me Et H Me Me O H Gc
Me H Et Me Me O H Gc
H Et Me Me Me O H Gc
H Me Et Me Me O H Gc
Et H Me Me Me O H Gc
Et Me H Me Me O H Gc
H H H Me Et O H Ga
R1 R2 R3 R4 R5 X M Gn
H H H Me Et S H G3
Me H H Me Et O H Ga
H Me H Me Et O H Ga
H H Me Me Et O H Ga
Et H H Me Et O H Gb
H Et H Me Et O H Gb
H H Et Me Et O H Gb
Pr-n H H Me Et O H Gb
H Pr-n H Me Et O H Gb
H H Pr-n Me Et O H Gb
Pr-i H H Me Et O H Gb
H Pr-i H Me Et O H Gb
H H Pr-i Me Et O H Gb
Bu-n H H Me Et O H Gc
H Bu-n H Me Et O H Gc
H H Bu-n Me Et O H Gc
Me Me H Me Et O H Gb
Me H Me Me Et O H Gb
H Me Me Me Et O H Gb
Me Me Me Me Et O H Gb
Et Et H Me Et O H Gc
Et H Et Me Et O H Gc
H Et Et Me Et O H Gc
Et Et Et Me Et O H Gc
Me Et H Me Et O H Gc
Me H Et Me Et O H Gc
H H Et Me Et O H Gc
Et H Me Me Et O H Gc
Et Me H Me Et O H Gc
H H H Me Pr-n S H G3
H H H Me Pr-n O H Ga
Me H H Me Pr-n O H Ga
H Me H Me Pr-n O H Ga
H H Me Me Pr-n O H Ga
Et H H Me Pr-n O H Gb
H Et H Me Pr-n O H Gb
H H Et Me Pr-n O H Gb
Pr-n H H Me Pr-n O H Gb
R1 R2 R3 R4 R5 X M Gn
H Pr-n H Me Pr-n O H Gb
H H Pr-n Me Pr-n O H Gb
Pr-i H H Me Pr-n O H Gb
H Pr-i H Me Pr-n O H Gb
H H Pr-i Me Pr-n O H Gb
Bu-n H H Me Pr-n O H Gc
H Bu-n H Me Pr-n O H Gc
H H Bu-n Me Pr-n O H Gc
Me Me H Me Pr-n O H Gb
Me H Me Me Pr-n O H Gb
H Me Me Me Pr-n O H Gb
Me Me Me Me Pr-n O H Gb
Et Et H Me Pr-n O H Gc
Et H Et Me Pr-n O H Gc
H Et Et Me Pr-n O H Gc
Et Et Et Me Pr-n O H Gc
Me Et H Me Pr-n O H Gc
Me H Et Me Pr-n O H Gc
H Et Me Me Pr-n O H Gc
H Me Et Me Pr-n O H Gc
Et H Me Me Pr-n O H Gc
Et Me H Me Pr-n O H Gc
H H H Me Pr-i O H Gb
H H H Me Pr-i S H G3
Me H H Me Pr-i O H Ga
H Me H Me Pr-i O H Ga
H H Me Me Pr-i O H Ga
Et H H Me Pr-i O H Gb
H Et H Me Pr-i O H Gb
H H Et Me Pr-i O H Gb
Pr-n H H Me Pr-i O H Gb
H Pr-n H Me Pr-i O H Gb
H H Pr-n Me Pr-i O H Gb
Pr-i H H Me Pr-i O H Gb
H Pr-i H Me Pr-i O H Gb
H H Pr-i Me Pr-i O H Gb
Bu-n H H Me Pr-i O H Gc
R1 R2 R3 R4 R5 X M Gn
H H Bu-n Me Pr-i O H Gc
Me Me H Me Pr-i O H Gb
Me H Me Me Pr-i O H Gb
H Me Me Me Pr-i O H Gb
Me Me Me Me Pr-i O H Gb
Et Et H Me Pr-i O H Gc
Et H Et Me Pr-i O H Gc
H Et Et Me Pr-i O H Gc
Et Et Et Me Pr-i O H Gc
Me Et H Me Pr-i O H Gc
Me H Et Me Pr-i O H Gc
H Et Me Me Pr-i O H Gc
H Me Et Me Pr-i O H Gc
Et H Me Me Pr-i O H Gc
Et Me H Me Pr-i O H Gc
H H H Et Et O H Gb
H H H Et Et S H G3
Me H H Et Et O H Ga
H Me H Et Et O H Ga
H H Me Et Et O H Ga
Et H H Et Et O H Gb
H Et H Et Et O H Gb
H H Et Et Et O H Gb
Pr-n H H Et Et O H Gb
H Pr-n H Et Et O H Gb
H H Pr-n Et Et O H Gb
Pr-i H H Et Et O H Gb
H Pr-i H Et Et O H Gb
H H Pr-i Et Et O H Gb
Bu-n H H Et Et O H Gc
H Bu-n H Et Et O H Gc
H H Bu-n Et Et O H Gc
Me Me H Et Et O H Gb
Me H Me Et Et O H Gb
H Me Me Et Et O H Gb
Me Me Me Et Et O H Gb
Et Et H Et Et O H Gc
Et H Et Et Et O H Gc
R1 R2 R3 R4 R5 X M Gn
H Et Et Et Et O H Gc
Et Et Et Et Et O H Gc
Me Et H Et Et O H Gc
Me H Et Et Et O H Gc
H Et Me Et Et O H Gc
H Me Et Et Et O H Gc
Et H Me Et Et O H Gc
Et Me H Et Et O H Gc
F H H Me Me O H Gb
Cl H H Me Me O H Gb
Br H H Me Me O H Gb
I H H Me Me O H Gc
CH＝CH2 H H Me Me O H Gb
CH2CH＝CH2 H H Me Me O H Gb
C≡CH H H Me Me O H Gb
CH2C≡CH H H Me Me O H Gb
CH2F H H Me Me O H Gb
CHF2 H H Me Me O H Gb
CN H H Me Me O H Gb
NH2 H H Me Me O H Gb
NHCOMe H H Me Me O H Gb
CH2NH2 H H Me Me O H Gb
CH2NHCOMe H H Me Me O H Gb
CH2OCHF2 H H Me Me O H Gb
CF3 H H Me Me O H Gb
NO2 H H Me Me O H Gb
OMe H H Me Me O H Ga
OEt H H Me Me O H Ga
OPr-n H H Me Me O H Gb
SMe H H Me Me O H Ga
SEt H H Me Me O H Ga
SO2Me H H Me Me O H Ga
COMe H H Me Me O H Ga
COEt H H Me Me O H Ga
CO2H H H Me Me O H Ga
CO2Me H H Me Me O H Ga
CO2Et H H Me Me O H Ga
CO2Pr-n H H Me Me O H Gb
R1 R2 R3 R4 R5 X M Gn
CO2Bu-n H H Me Me O H Gc
CH2Cl H H Me Me O H Ga
CH2Br H H Me Me O H Gb
CH2I H H Me Me O H Gb
CH2CF3 H H Me Me O H Gb
CH2CN H H Me Me O H Ga
CH2OH H H Me Me O H Gb
CH2OMe H H Me Me O H Ga
CH2OEt H H Me Me O H Ga
CH2OPr-n H H Me Me O H Gb
CH2SMe H H Me Me O H Ga
CH2SEt H H Me Me O H Ga
CH2SO2Me H H Me Me O H Ga
CH2SO2Et H H Me Me O H Ga
CH2SPr-n H H Me Me O H Gb
CH2SPr-i H H Me Me O H Gb
CH2COMe H H Me Me O H Ga
CH2COEt H H Me Me O H Ga
CH2COPr-n H H Me Me O H Gb
CH2CO2H H H Me Me O H Ga
CH2CO2Me H H Me Me O H Ga
CH2CO2Et H H Me Me O H Ga
CH2CO2Pr-n H H Me Me O H Gb
CH2OCH2CH＝CH2 H H Me Me O H Gb
CH2OCH2C≡CH H H Me Me O H Gb
CH＝CHCO2Me H H Me Me O H Ga
CH＝CHCO2Et H H Me Me O H Ga
CH＝CHCO2Pr-n H H Me Me O H Gb
CH＝CHCN H H Me Me O H Ga
Ph H H Me Me O H Ga
CH2Ph H H Me Me O H Ga
OPh H H Me Me O H Ga
SPh H H Me Me O H Ga
SO2Ph H H Me Me O H Ga
CONHMe H H Me Me O H Ga
CONHEt H H Me Me O H Ga
CON(Me)2 H H Me Me O H Ga
CON(Et)2 H H Me Me O H Ga
CON(Pr-n)2 H H Me Me O H Gb
H F H Me Me O H Gb
R1 R2 R3 R4 R5 X M Gn
H Cl H Me Me O H Gb
H Br H Me Me O H Gb
H I H Me Me O H Gc
H CH＝CH2 H Me Me O H Gb
H CH2CH＝CH2 H Me Me O H Gb
H C≡CH H Me Me O H Gb
H CH2C≡CH H Me Me O H Gb
H CH2F H Me Me O H Gb
H CHF2 H Me Me O H Gb
H CN H Me Me O H Gb
H NH2 H Me Me O H Gb
H NHCOMe H Me Me O H Gb
H CH2NH2 H Me Me O H Gb
H CH2NHCOMe H Me Me O H Gb
H CH2OCHF2 H Me Me O H Gb
H CF3 H Me Me O H Gb
H NO2 H Me Me O H Gb
H OMe H Me Me O H Ga
H OEt H Me Me O H Ga
H OPr-n H Me Me O H Gb
H SMe H Me Me O H Ga
H SEt H Me Me O H Ga
H SO2Me H Me Me O H Ga
H COMe H Me Me O H Ga
H COEt H Me Me O H Ga
H CO2H H Me Me O H Ga
H CO2Me H Me Me O H Ga
H CO2Et H Me Me O H Ga
H CO2Pr-n H Me Me O H Gb
H CO2Bu-n H Me Me O H Gc
H CH2Cl H Me Me O H Ga
H CH2Br H Me Me O H Gb
H CH2I H Me Me O H Gb
H CH2CF3 H Me Me O H Gb
H CH2CN H Me Me O H Ga
H CH2OH H Me Me O H Gb
H CH2OMe H Me Me O H Ga
H CH2OEt H Me Me O H Ga
H CH2OPr-n H Me Me O H Gb
H CH2SMe H Me Me O H Ga
R1 R2 R3 R4 R5 X M Gn
H CH2SEt H Me Me O H Ga
H CH2SO2Me H Me Me O H Ga
H CH2SO2Et H Me Me O H Ga
H CH2SPr-n H Me Me O H Gb
H CH2SPr-i H Me Me O H Gb
H CH2COMe H Me Me O H Ga
H CH2COEt H Me Me O H Ga
H CH2COPr-n H Me Me O H Gb
H CH2CO2H H Me Me O H Ga
H CH2CO2Me H Me Me O H Ga
H CH2CO2Et H Me Me O H Ga
H CH2CO2Pr-n H Me Me O H Gb
H CH2OCH2CH＝CH2 H Me Me O H Gb
H CH2OCH2C≡CH H Me Me O H Gb
H CH＝CHCO2Me H Me Me O H Ga
H CH＝CHCO2Et H Me Me O H Ga
H CH＝CHCO2Pr-n H Me Me O H Gb
H CH＝CHCN H Me Me O H Ga
H Ph H Me Me O H Ga
H CH2Ph H Me Me O H Ga
H OPh H Me Me O H Ga
H SPh H Me Me O H Ga
H SO2Ph H Me Me O H Ga
H CONHMe H Me Me O H Ga
H CONHEt H Me Me O H Ga
H CON(Me)2 H Me Me O H Ga
H CON(Et)2 H Me Me O H Ga
H CON(Pr-n)2 H Me Me O H Gb
H H F Me Me O H Gb
H H Cl Me Me O H Gb
H H Br Me Me O H Gb
H H I Me Me O H Gc
H H CH＝CH2 Me Me O H Gb
H H CH2CH＝CH2Me Me O H Gb
H H C≡CH Me Me O H Gb
H H CH2C≡CH Me Me O H Gb
H H CH2F Me Me O H Gb
H H CHF2 Me Me O H Gb
H H CN Me Me O H Gb
H H NH2 Me Me O H Gb
R1 R2 R3 R4 R5 X M Gn
H H NHCOMe Me Me O H Gb
H H CH2NH2 Me Me O H Gb
H H CH2NHCOMe Me Me O H Gb
H H CH2OCHF2 Me Me O H Gb
H H CF3 Me Me O H Gb
H H NO2 Me Me O H Gb
H H OMe Me Me O H Ga
H H OEt Me Me O H Ga
H H OPr-n Me Me O H Gb
H H SMe Me Me O H Ga
H H SEt Me Me O H Ga
H H SO2Me Me Me O H Ga
H H COMe Me Me O H Ga
H H COEt Me Me O H Ga
H H CO2H Me Me O H Ga
H H CO2Me Me Me O H Ga
H H CO2Et Me Me O H Ga
H H CO2Pr-n Me Me O H Gb
H H CO2Bu-n Me Me O H Gc
H H CH2Cl Me Me O H Ga
H H CH2Br Me Me O H Gb
H H CH2I Me Me O H Gb
H H CH2CF3 Me Me O H Gb
H H CH2CN Me Me O H Ga
H H CH2OH Me Me O H Gb
H H CH2OMe Me Me O H Ga
H H CH2OEt Me Me O H Ga
H H CH2OPr-n Me Me O H Gb
H H CH2SMe Me Me O H Ga
H H CH2SEt Me Me O H Ga
H H CH2SO2Me Me Me O H Ga
H H CH2SO2Et Me Me O H Ga
H H CH2SPr-n Me Me O H Gb
H H CH2SPr-i Me Me O H Gb
H H CH2COMe Me Me O H Ga
H H CH2COEt Me Me O H Ga
H H CH2COPr-n Me Me O H Gb
H H CH2CO2H Me Me O H Ga
H H CH2CO2Me Me Me O H Ga
H H CH2CO2Et Me Me O H Ga
R1 R2 R3 R4 R5 X M Gn
H H CH2CO2Pr-n Me Me O H Gb
H H CH2OCH2CH＝CH2 Me Me O H Gb
H H CH2OCH2C≡CH Me Me O H Gb
H H CH＝CHCO2Me Me Me O H Ga
H H CH＝CHCO2Et Me Me O H Ga
H H CH＝CHCO2Pr-n Me Me O H Gb
H H CH＝CHCN Me Me O H Ga
H H Ph Me Me O H Ga
H H CH2Ph Me Me O H Ga
H H OPh Me Me O H Ga
H H SPh Me Me O H Ga
H H SO2Ph Me Me O H Ga
H H CONHMe Me Me O H Ga
H H CONHEt Me Me O H Ga
H H CON(Me)2 Me Me O H Ga
H H CON(Et)2 Me Me O H Ga
H H CON(Pr-n)2 Me Me O H Gb
F H H Me Et O H Gb
Cl H H Me Et O H Gb
Br H H Me Et O H Gb
I H H Me Et O H Gc
CH＝CH2 H H Me Et O H Gb
CH2CH＝CH2H H Me Et O H Gb
C≡CH H H Me Et O H Gb
CH2C≡CH H H Me Et O H Gb
CH2F H H Me Et O H Gb
CHF2 H H Me Et O H Gb
CN H H Me Et O H Gb
NH2 H H Me Et O H Gb
NHCOMe H H Me Et O H Gb
CH2NH2 H H Me Et O H Gb
CH2NHCOMe H H Me Et O H Gb
CH2OCHF2 H H Me Et O H Gb
CF3 H H Me Et O H Gb
NO2 H H Me Et O H Gb
OMe H H Me Et O H Ga
OEt H H Me Et O H Ga
OPr-n H H Me Et O H Gb
SMe H H Me Et O H Ga
SEt H H Me Et O H Ga
R1 R2 R3 R4 R5 X M Gn
SO2Me H H Me Et O H Ga
COMe H H Me Et O H Ga
COEt H H Me Et O H Ga
CO2H H H Me Et O H Ga
CO2Me H H Me Et O H Ga
CO2Et H H Me Et O H Ga
CO2Pr-n H H Me Et O H Gb
CO2Bu-n H H Me Et O H Gc
CH2Cl H H Me Et O H Ga
CH2Br H H Me Et O H Gb
CH2I H H Me Et O H Gb
CH2CF3 H H Me Et O H Gb
CH2CN H H Me Et O H Ga
CH2OH H H Me Et O H Gb
CH2OMe H H Me Et O H Ga
CH2OEt H H Me Et O H Ga
CH2OPr-n H H Me Et O H Gb
CH2SMe H H Me Et O H Ga
CH2SEt H H Me Et O H Ga
CH2SO2Me H H Me Et O H Ga
CH2SO2Et H H Me Et O H Ga
CH2SPr-n H H Me Et O H Gb
CH2SPr-i H H Me Et O H Gb
CH2COMe H H Me Et O H Ga
CH2COEt H H Me Et O H Ga
CH2COPr-n H H Me Et O H Gb
CH2CO2H H H Me Et O H Ga
CH2CO2Me H H Me Et O H Ga
CH2CO2Et H H Me Et O H Ga
CH2CO2Pr-n H H Me Et O H Gb
CH2OCH2CH＝CH2H H Me Et O H Gb
CH2OCH2C≡CH H H Me Et O H Gb
CH＝CHCO2Me H H Me Et O H Ga
CH＝CHCO2Et H H Me Et O H Ga
CH＝CHCO2Pr-n H H Me Et O H Gb
CH＝CHCN H H Me Et O H Ga
Ph H H Me Et O H Ga
CH2Ph H H Me Et O H Ga
OPh H H Me Et O H Ga
SPh H H Me Et O H Ga
R1 R2 R3 R4 R5 X M Gn
SO2Ph H H Me Et O H Ga
CONHMe H H Me Et O H Ga
CONHEt H H Me Et O H Ga
CON(Me)2 H H Me Et O H Ga
CON(Et)2 H H Me Et O H Ga
CON(Pr-n)2 H H Me Et O H Gb
H H H F H O H Gb
H H H F H S H G3
H H H Cl H O H Gb
H H H Cl H S H G3
H H H Br H O H Gb
H H H Br H S H G3
H H H I H O H Gc
H H H CH＝CH2 H O H Gb
H H H CH＝CH2 H S H G3
H H H CH2CH＝CH2H O H Gb
H H H C≡CH H O H Gb
H H H CH2C≡CH H O H Gb
H H H CH2F H O H Gb
H H H CH2F H S H G3
H H H CHF2 H O H Gb
H H H CHF2 H S H G3
H H H CN H O H Gb
H H H CN H S H G3
H H H NH2 H O H Gb
H H H NHCOMe H O H Gb
H H H CH2NH2 H O H Gb
H H H CH2NHCOMe H O H Gb
H H H CH2OCHF2 H O H Gb
H H H CH2OCHF2 H S H G3
H H H CF3 H O H Gb
H H H CF3 H S H G3
H H H CF3 H O Me Gb
H H H CF3 H O Et Gb
H H H CF3 H O CH2CH＝CH2Gb
H H H CF3 H O CH2C≡CH Gb
H H H NO2 H O H Gb
H H H NO2 H S H G3
H H H OMe H O H Ga
H H H OMe H S H G3
R1 R2 R3 R4 R5 X M Gn
H H H OMe H O Me Gb
H H H OMe H O Et Gb
H H H OMe H O CH2CH＝CH2Gb
H H H OMe H O CH2C≡CH Gb
H H H OEt H O H Ga
H H H OEt H S H G3
H H H OPr-n H O H Gb
H H H OPr-n H S H G3
H H H SMe H O H Ga
H H H SMe H S H G3
H H H SEt H O H Ga
H H H SEt H S H G3
H H H SPr-n H O H Gb
H H H SPr-n H S H G3
H H H SBu-n H O H Gc
H H H SPen-n H O H Gc
H H H SO2Me H O H Ga
H H H SO2Me H S H G3
H H H SO2Et H O H Ga
H H H SO2Et H S H G3
H H H SO2Pr-n H O H Gb
H H H SO2Pr-n H S H G3
H H H COMe H O H Ga
H H H COMe H S H G3
H H H COEt H O H Ga
H H H COEt H S H G3
H H H COPr-n H O H Gb
H H H COPr-n H S H G3
H H H CO2H H O H Ga
H H H CO2H H S H G3
H H H CO2Me H O H Ga
H H H CO2Me H S H G3
H H H CO2Me H O Me Gb
H H H CO2Me H O Et Gb
H H H CO2Me H O CH2CH＝CH2Gb
H H H CO2Me H O CH2C≡CH Gb
H H H CO2Et H O H Ga
H H H CO2Et H S H G3
H H H CO2Pr-n H O H Gb
H H H CO2Pr-n H S H G3
R1 R2 R3 R4 R5 X M Gn
H H H CO2Pr-i H O H Gb
H H H CO2Pr-i H S H G3
H H H CO2Bu-n H O H Gc
H H H CO2Bu-t H O H Gc
H H H CO2Bu-sec H O H Gc
H H H CO2Pen-n H O H Gc
H H H CH2Cl H O H Ga
H H H CH2Cl H S H G3
H H H CH2Br H O H Gb
H H H CH2Br H S H G3
H H H CH2I H O H Gb
H H H CH2I H S H G3
H H H CH2CF3 H O H Gb
H H H GH2GF3 H S H G3
H H H CH2CN H O H Ga
H H H CH2CN H S H G3
H H H CH2OH H O H Gb
H H H CH2OH H S H G3
H H H CH2OMe H O H Ga
H H H CH2OMe H S H G3
H H H CH2OMe H O Me Gb
H H H CH2OMe H O Et Gb
H H H CH2OMe H O CH2CH＝CH2Gb
H H H CH2OMe H O CH2G≡CH Gb
H H H CH2OEt H O H Ga
H H H CH2OEt H S H G3
H H H CH2OPr-n H O H Gb
H H H CH2OPr-n H S H G3
H H H CH2OPr-i H O H Gb
H H H CH2OPr-i H S H G3
H H H CH2SMe H O H Ga
H H H CH2SMe H S H G3
H H H CH2SEt H O H Ga
H H H CH2SEt H S H G3
H H H CH2SO2Me H O H Ga
H H H CH2SO2Et H O H Ga
H H H CH2SO2Me H S H G3
H H H CH2SO2Et H S H G3
H H H CH2SPr-n H O H Gb
H H H CH2SPr-n H S H G3
R1 R2 R3 R4 R5 X M Gn
H H H CH2SPr-i H O H Gb
H H H CH2SPr-i H S H G3
H H H CH2COMe H O H Ga
H H H CH2COMe H S H G3
H H H CH2COEt H O H Ga
H H H CH2COEt H S H G3
H H H CH2COPr-n H O H Gb
H H H CH2COPr-n H S H G3
H H H CH2COPr-i H O H Gb
H H H CH2COPr-i H S H G3
H H H CH2CO2H H O H Ga
H H H CH2CO2H H S H G3
H H H CH2CO2Me H O H Ga
H H H CH2CO2Me H S H G3
H H H CH2CO2Et H O H Ga
H H H CH2CO2Et H S H G3
H H H CH2CO2Pr-n H O H Gb
H H H CH2CO2Pr-n H S H G3
H H H CH2CO2Pr-i H O H Gb
H H H CH2CO2Pr-i H S H G3
H H H CH2OCH2CH＝CH2H O H Gb
H H H CH2OCH2CH＝CH2H S H G3
H H H CH2OCH2C≡CH H O H Gb
H H H CH2OCH2C≡CH H S H G3
H H H CH＝CHCO2Me H O H Ga
H H H CH＝CHCO2Me H S H G3
H H H CH＝CHCO2Et H O H Ga
H H H CH＝CHCO2Et H S H G3
H H H CH＝CHCO2Pr-n H O H Gb
H H H CH＝CHCO2Pr-n H S H G3
H H H CH＝CHCO2Pr-i H O H Gb
H H H CH＝CHCO2Pr-i H S H G3
H H H CH＝CHCN H O H Ga
H H H CH＝CHCN H S H G3
H H H Ph H O H Ga
H H H Ph H S H G3
H H H Ph H O Me Gb
H H H Ph H O Et Gb
H H H Ph H O CH2CH＝CH2Gb
H H H Ph H O CH2C≡CH Gb
R1 R2 R3 R4 R5 X M Gn
H H H Ph-2-F H O H Ga
H H H Ph-2-F H S H G3
H H H Ph-3-F H O H Gb
H H H Ph-4-F H O H Gb
H H H Ph-2-Cl H O H Ga
H H H Ph-2-Cl H S H G3
H H H Ph-3-Cl H O H Gb
H H H Ph-4-Cl H O H Gb
H H H Ph-2-Br H O H Ga
H H H Ph-2-Br H S H G3
H H H Ph-3-Br H O H Gb
H H H Ph-4-Br H O H Gb
H H H Ph-2-CF3 H O H Ga
H H H Ph-2-CF3 H S H G3
H H H Ph-3-CF3 H O H Gb
H H H Ph-4-CF3 H O H Gb
H H H Ph-2-Me H O H Ga
H H H Ph-2-Me H S H G3
H H H Ph-3-Me H O H Gb
H H H Ph-4-Me H O H Gb
H H H Ph-2-Et H O H Ga
H H H Ph-2-Et H S H G3
H H H Ph-2-OMe H O H Ga
H H H Ph-2-OMe H S H G3
H H H Ph-3-OMe H O H Gb
H H H Ph-4-OMe H O H Gb
H H H Ph-2-OEt H O H Ga
H H H Ph-2-OEt H S H G3
H H H Ph-2-CO2Me H O H Ga
H H H Ph-2-CO2Me H S H G3
H H H Ph-2-CO2Et H O H Ga
H H H Ph-2-CO2Et H S H G3
H H H Ph-3-CO2Me H O H Gb
H H H Ph-4-CO2Me H O H Gb
H H H CH2Ph H O H Ga
H H H CH2Ph H S H G3
H H H CH2Ph H O Me Gb
H H H CH2Ph H O Et Gb
H H H CH2Ph H O CH2CH＝CH2Gb
H H H CH2Ph H O CH2C≡CH Gb
R1 R2 R3 R4 R5 X M Gn
H H H SPh-2-CF3 H O H Ga
H H H SPh-2-CF3 H S H G3
H H H SPh-3-CF3 H O H Gb
H H H SPh-4-CF3 H O H Gb
H H H SPh-2-Me H O H Ga
H H H SPh-2-Me H S H G3
H H H SPh-3-Me H O H Gb
H H H SPh-4-Me H O H Gb
H H H SPh-2-Et H O H Ga
H H H SPh-2-Et H S H G3
H H H SPh-2-OMe H O H Ga
H H H SPh-2-OMe H S H G3
H H H SPh-3-OMe H O H Gb
H H H SPh-4-OMe H O H Gb
H H H SPh-2-OEt H O H Ga
H H H SPh-2-OEt H S H G3
H H H SPh-2-CO2Me H O H G3
H H H SPh-2-CO2Me H S H G3
H H H SPh-3-CO2Me H O H Gb
H H H SPh-4-CO2Me H O H Gb
H H H SPh-2-CO2Et H O H Ga
H H H SPh-2-CO2Et H S H G3
H H H SO2Ph H O H Ga
H H H SO2Ph H S H G3
H H H SO2Ph-2-Cl H O H Ga
H H H SO2Ph-2-Cl H S H G3
H H H SO2Ph-3-Cl H O H Gb
H H H SO2Ph-4-Cl H O H Gb
H H H SO2Ph-2-F H O H Ga
H H H SO2Ph-2-F H S H G3
H H H SO2Ph-3-F H O H Gb
H H H SO2Ph-4-F H O H Gb
H H H SO2Ph-2-CF3 H O H Ga
H H H SO2Ph-2-CF3 H S H G3
H H H SO2Ph-3-CF3 H O H Gb
H H H SO2Ph-4-CF3 H O H Gb
H H H SO2Ph-2-Me H O H Ga
H H H SO2Ph-2-Me H S H G3
H H H SO2Ph-3-Me H O H Gb
H H H SO2Ph-4-Me H O H Gb
R1 R2 R3 R4 R5 X M Gn
H H H SO2Ph-2-Et H O H Ga
H H H SO2Ph-2-Et H S H G3
H H H SO2Ph-2-OMe H O H Ga
H H H SO2Ph-2-OMe H S H G3
H H H SO2Ph-3-OMe H O H Gb
H H H SO2Ph-4-OMe H O H Gb
H H H SO2Ph-2-OEt H O H Ga
H H H SO2Ph-2-OEt H S H G3
H H H SO2Ph-2-CO2Me H O H Ga
H H H SO2Ph-2-CO2Me H S H G3
H H H SO2Ph-3-CO2Me H O H Gb
H H H SO2Ph-4-CO2Me H O H Gb
H H H SO2Ph-2-CO2Et H O H Ga
H H H SO2Ph-2-CO2Et H S H G3
H H H CONHMe H O H Ga
H H H CONHMe H S H G3
H H H CONHEt H O H Ga
H H H CONHEt H S H G3
H H H CONHPr-n H O H Gb
H H H CONHPr-n H S H G3
H H H CONHPr-i H O H Gb
H H H CONHPr-i H S H G3
H H H CONHBu-n H O H Gb
H H H CONHBu-sec H O H Gb
H H H CONHBu-t H O H Gb
H H H CON(Me)2 H O H Ga
H H H CON(Me)2 H S H G3
H H H CON(Et)2 H O H Ga
H H H CON(Et)2 H S H G3
H H H CON(Pr-n)2 H O H Gb
H H H CON(Pr-n)2 H S H G3
F H H H H O H Gb
F H H H H S H G3
Cl H H H H O H Gb
Cl H H H H S H G3
Br H H H H O H Gb
Br H H H H S H G3
I H H H H O H Gc
CH＝CH2 H H H H O H Gb
CH＝CH2 H H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H H H CH2Ph-2-F H O H Ga
H H H CH2Ph-2-F H S H G3
H H H CH2Ph-3-F H O H Gb
H H H CH2Ph-4-F H O H Gb
H H H CH2Ph-2-Cl H O H Ga
H H H CH2Ph-2-Cl H S H G3
H H H CH2Ph-3-Cl H O H Gb
H H H CH2Ph-4-Cl H O H Gb
H H H CH2Ph-2-Br H O H Ga
H H H CH2Ph-2-Br H S H G3
H H H CH2Ph-3-Br H O H Gb
H H H CH2Ph-4-Br H O H Gb
H H H CH2Ph-2-CF3 H O H Ga
H H H CH2Ph-2-CF3 H S H G3
H H H CH2Ph-3-CF3 H O H Gb
H H H CH2Ph-4-CF3 H O H Gb
H H H CH2Ph-2-Me H O H Ga
H H H CH2Ph-2-Me H S H G3
H H H CH2Ph-3-Me H O H Gb
H H H CH2Ph-4-Me H O H Gb
H H H CH2Ph-2-Et H O H Ga
H H H CH2Ph-2-Et H S H G3
H H H CH2Ph-2-OMe H O H Ga
H H H CH2Ph-2-OMe H S H G3
H H H CH2Ph-3-OMe H O H Gb
H H H CH2Ph-4-OMe H O H Gb
H H H CH2Ph-2-OEt H O H Ga
H H H CH2Ph-2-OEt H S H G3
H H H CH2Ph-2-CO2Me H O H Ga
H H H CH2Ph-2-CO2Me H S H G3
H H H CH2Ph-2-CO2Et H O H Ga
H H H CH2Ph-2-CO2Et H S H G3
H H H CH2Ph-3-CO2Me H O H Gb
H H H CH2Ph-4-CO2Me H O H Gb
H H H OPh H O H Ga
H H H OPh H S H G3
H H H OPh H O Me Gb
H H H OPh H O Et Gb
H H H OPh H O CH2CH＝CH2Gb
H H H OPh H O CH2C≡CH Gb
R1 R2 R3 R4 R5 X M Gn
H H H OPh-2-Cl H O H Ga
H H H OPh-2-Cl H S H G3
H H H OPh-3-Cl H O H Gb
H H H OPh-4-Cl H O H Gb
H H H OPh-2-F H O H Ga
H H H OPh-2-F H S H G3
H H H OPh-3-F H O H Gb
H H H OPh-4-F H O H Gb
H H H OPh-2-CF3 H O H Ga
H H H OPh-2-CF3 H S H G3
H H H OPh-3-CF3 H O H Gb
H H H OPh-4-CF3 H O H Gb
H H H OPh-2-Me H O H Ga
H H H OPh-2-Me H S H G3
H H H OPh-3-Me H O H Gb
H H H OPh-4-Me H O H Gb
H H H OPh-2-Et H O H Ga
H H H OPh-2-Et H S H G3
H H H OPh-2-OMe H O H Ga
H H H OPh-2-OMe H S H G3
H H H OPh-3-OMe H O H Gb
H H H OPh-4-OMe H O H Gb
H H H OPh-2-OEt H O H Ga
H H H OPh-2-OEt H S H G3
H H H OPh-2-CO2Me H O H Ga
H H H OPh-2-CO2Me H S H G3
H H H OPh-3-CO2Me H O H Gb
H H H OPh-4-CO2Me H O H Gb
H H H OPh-2-CO2Et H O H Ga
H H H OPh-2-CO2Et H S H G3
H H H SPh H O H Ga
H H H SPh H S H G3
H H H SPh-2-Cl H O H Ga
H H H SPh-2-Cl H S H G3
H H H SPh-3-Cl H O H Gb
H H H SPh-4-Cl H O H Gb
H H H SPh-2-F H O H Ga
H H H SPh-2-F H S H G3
H H H SPh-3-F H O H Gb
H H H SPh-4-F H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH2CH＝CH2 H H H H O H Gb
C≡CH H H H H O H Gb
CH2C≡CH H H H H O H Gb
CH2F H H H H O H Gb
CH2F H H H H S H G3
CHF2 H H H H O H Gb
CHF2 H H H H S H G3
CN H H H H O H Gb
CN H H H H S H G3
NH2 H H H H O H Gb
NHCOMe H H H H O H Gb
CH2NH2 H H H H O H Gb
CH2NHCOMe H H H H O H Gb
CH2OCHF2 H H H H O H Gb
CH2OCHF2 H H H H S H G3
CF3 H H H H O H Gb
CF3 H H H H S H G3
CF3 H H H H O Me Gb
CF3 H H H H O Et Gb
CF3 H H H H O CH2CH＝CH2Gb
CF3 H H H H O CH2C≡GH Gb
NO2 H H H H O H Gb
NO2 H H H H S H G3
OMe H H H H O H Ga
OMe H H H H S H G3
OMe H H H H O Me Gb
OMe H H H H O Et Gb
OMe H H H H O CH2CH＝CH2Gb
OMe H H H H O CH2C≡CH Gb
OEt H H H H O H Ga
OEt H H H H S H G3
OPr-n H H H H O H Gb
OPr-n H H H H S H G3
SMe H H H H O H Ga
SMe H H H H S H G3
SEt H H H H O H Ga
SEt H H H H S H G3
SPr-n H H H H O H Gb
SPr-n H H H H S H G3
SRu-n H H H H O H Gc
R1 R2 R3 R4 R5 X M Gn
SPen-n H H H H O H Gc
SO2Me H H H H O H Ga
SO2Me H H H H S H G3
SO2Et H H H H O H Ga
SO2Et H H H H S H G3
SO2Pr-n H H H H O H Gb
SO2Pr-n H H H H S H G3
COMe H H H H O H Ga
COMe H H H H S H G3
COEt H H H H O H Ga
COEt H H H H S H G3
COPr-n H H H H O H Gb
COPr-n H H H H S H G3
CO2H H H H H O H Ga
CO2H H H H H S H G3
CO2Me H H H H O H Ga
CO2Me H H H H S H G3
CO2Me H H H H O Me Gb
CO2Me H H H H O Et Gb
CO2Me H H H H O CH2CH＝CH2Gb
CO2Me H H H H O CH2C≡CH Gb
CO2Et H H H H O H Ga
CO2Et H H H H S H G3
CO2Pr-n H H H H O H Gb
CO2Pr-n H H H H S H G3
CO2Pr-i H H H H O H Gb
CO2Pr-i H H H H S H G3
CO2Bu-n H H H H O H Gc
CO2Bu-t H H H H O H Gc
CO2Bu-sec H H H H O H Gc
CO2Pen-n H H H H O H Gc
CH2Cl H H H H O H Ga
CH2Cl H H H H S H G3
CH2Br H H H H O H Gb
CH2Br H H H H S H G3
CH2I H H H H O H Gb
CH2I H H H H S H G3
CH2CF3 H H H H O H Gb
CH2CF3 H H H H S H G3
CH2CN H H H H O H Ga
R1 R2 R3 R4 R5 X M Gn
CH2CN H H H H S H G3
CH2OH H H H H O H Gb
CH2OH H H H H S H G3
CH2OMe H H H H O H Ga
CH2OMe H H H H S H G3
CH2OMe H H H H O Me Gb
CH2OMe H H H H O Et Gb
CH2OMe H H H H O CH2CH＝CH2Gb
CH2OMe H H H H O CH2C≡CH Gb
CH2OEt H H H H O H Ga
CH2OEt H H H H S H G3
CH2OPr-n H H H H O H Gb
CH2OPr-n H H H H S H G3
CH2OPr-i H H H H O H Gb
CH2OPr-i H H H H S H G3
CH2SMe H H H H O H Ga
CH2SMe H H H H S H G3
CH2SEt H H H H O H Ga
CH2SEt H H H H S H G3
CH2SO2Me H H H H O H Ga
CH2SO2Et H H H H O H Ga
CH2SO2Me H H H H S H G3
CH2SO2Et H H H H S H G3
CH2SPr-n H H H H O H Gb
CH2SPr-n H H H H S H G3
CH2SPr-i H H H H O H Gb
CH2SPr-i H H H H S H G3
CH2COMe H H H H O H Ga
CH2COMe H H H H S H G3
CH2COEt H H H H O H Ga
CH2COEt H H H H S H G3
CH2COPr-n H H H H O H Gb
CH2COPr-n H H H H S H G3
CH2COPr-i H H H H O H Gb
CH2COPr-i H H H H S H G3
CH2CO2H H H H H O H Ga
CH2CO2H H H H H S H G3
CH2CO2Me H H H H O H Ga
CH2CO2Me H H H H S H G3
CH2CO2Et H H H H O H Ga
R1 R2 R3 R4 R5 X M Gn
CH2CO2Et H H H H S H G3
CH2CO2Pr-n H H H H O H Gb
CH2CO2Pr-n H H H H S H G3
CH2CO2Pr-i H H H H O H Gb
CH2CO2Pr-i H H H H S H G3
CH2OCH2CH＝CH2 H H H H O H Gb
CH2OCH2CH＝CH2 H H H H S H G3
CH2OCH2C≡CH H H H H O H Gb
CH2OCH2C≡CH H H H H S H G3
CH＝CHCO2Me H H H H O H Ga
CH＝CHCO2Me H H H H S H G3
CH＝CHCO2Et H H H H O H Ga
CH＝CHCO2Et H H H H S H G3
CH＝CHCO2Pr-n H H H H O H Gb
CH＝CHCO2Pr-n H H H H S H G3
CH＝CHCO2Pr-i H H H H O H Gb
CH＝CHCO2Pr-i H H H H S H G3
CH＝CHCN H H H H O H Ga
CH＝CHCN H H H H S H G3
Ph H H H H O H Ga
Ph H H H H S H G3
Ph H H H H O Me Gb
Ph H H H H O Et Gb
Ph H H H H O CH2CH＝CH2Gb
Ph H H H H O CH2C≡CH Gb
Ph-2-F H H H H O H Ga
Ph-2-F H H H H S H G3
Ph-3-F H H H H O H Gb
Ph-4-F H H H H O H Gb
Ph-2-Cl H H H H O H Ga
Ph-2-Cl H H H H S H G3
Ph-3-Cl H H H H O H Gb
Ph-4-Cl H H H H O H Gb
Ph-2-Br H H H H O H Ga
Ph-2-Br H H H H S H G3
Ph-3-Br H H H H O H Gb
Ph-4-Br H H H H O H Gb
Ph-2-CF3 H H H H O H Ga
Ph-2-CF3 H H H H S H G3
Ph-3-CF3 H H H H O H Gb
R1 R2 R3 R4 R5 X M Gn
Ph-4-CF3 H H H H O H Gb
Ph-2-Me H H H H O H Ga
Ph-2-Me H H H H S H G3
Ph-3-Me H H H H O H Gb
Ph-4-Me H H H H O H Gb
Ph-2-Et H H H H O H Ga
Ph-2-Et H H H H S H G3
Ph-2-OMe H H H H O H Ga
Ph-2-OMe H H H H S H G3
Ph-3-OMe H H H H O H Gb
Ph-4-OMe H H H H O H Gb
Ph-2-OEt H H H H O H Ga
Ph-2-OEt H H H H S H G3
Ph-2-CO2Me H H H H O H Ga
Ph-2-CO2Me H H H H S H G3
Ph-2-CO2Et H H H H O H Ga
Ph-2-CO2Et H H H H S H G3
Ph-3-CO2Me H H H H O H Gb
Ph-4-CO2Me H H H H O H Gb
CH2Ph H H H H O H Ga
CH2Ph H H H H S H G3
CH2Ph H H H H O Me Gb
CH2Ph H H H H O Et Gb
CH2Ph H H H H O CH2CH＝CH2Gb
CH2Ph H H H H O CH2C≡CH Gb
CH2Ph-2-F H H H H O H Ga
CH2Ph-2-F H H H H S H G3
CH2Ph-3-F H H H H O H Gb
CH2Ph-4-F H H H H O H Gb
CH2Ph-2-Cl H H H H O H Ga
CH2Ph-2-Cl H H H H S H G3
CH2Ph-3-Cl H H H H O H Gb
CH2Ph-4-Cl H H H H O H Gb
CH2Ph-2-Br H H H H O H Ga
CH2Ph-2-Br H H H H S H G3
CH2Ph-3-Br H H H H O H Gb
CH2Ph-4-Br H H H H O H Gb
CH2Ph-2-CF3 H H H H O H Ga
CH2Ph-2-CF3 H H H H S H G3
CH2Ph-3-CF3 H H H H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH2Ph-4-CF3 H H H H O H Gb
CH2Ph-2-Me H H H H O H Ga
CH2Ph-2-Me H H H H S H G3
CH2Ph-3-Me H H H H O H Gb
CH2Ph-4-Me H H H H O H Gb
CH2Ph-2-Et H H H H O H Ga
CH2Ph-2-Et H H H H S H G3
CH2Ph-2-OMe H H H H O H Ga
CH2Ph-2-OMe H H H H S H G3
CH2Ph-3-OMe H H H H O H Gb
CH2Ph-4-OMe H H H H O H Gb
CH2Ph-2-OEt H H H H O H Ga
CH2Ph-2-OEt H H H H S H G3
CH2Ph-2-CO2Me H H H H O H Ga
CH2Ph-2-CO2Me H H H H S H G3
CH2Ph-2-CO2Et H H H H O H Ga
CH2Ph-2-CO2Et H H H H S H G3
CH2Ph-3-CO2Me H H H H O H Gb
CH2Ph-4-CO2Me H H H H O H Gb
OPh H H H H O H Ga
OPh H H H H S H G3
OPh H H H H O Me Gb
OPh H H H H O Et Gb
OPh H H H H O CH2CH＝CH2Gb
OPh H H H H O CH2C≡CH Gb
OPh-2-Cl H H H H O H Ga
OPh-2-Cl H H H H S H G3
OPh-3-Cl H H H H O H Gb
OPh-4-Cl H H H H O H Gb
OPh-2-F H H H H O H Ga
OPh-2-F H H H H S H G3
OPh-3-F H H H H O H Gb
OPh-4-F H H H H O H Gb
OPh-2-CF3 H H H H O H Ga
OPh-2-CF3 H H H H S H G3
OPh-3-CF3 H H H H O H Gb
OPh-4-CF3 H H H H O H Gb
OPh-2-Me H H H H O H Ga
OPh-2-Me H H H H S H G3
OPh-3-Me H H H H O H Gb
R1 R2 R3 R4 R5 X M Gn
OPh-4-Me H H H H O H Gb
OPh-2-Et H H H H O H Ga
OPh-2-Et H H H H S H G3
OPh-2-OMe H H H H O H Ga
OPh-2-OMe H H H H S H G3
OPh-3-OMe H H H H O H Gb
OPh-4-OMe H H H H O H Gb
OPh-2-OEt H H H H O H Ga
OPh-2-OEt H H H H S H G3
OPh-2-CO2Me H H H H O H Ga
OPh-2-CO2Me H H H H S H G3
OPh-3-GO2Me H H H H O H Gb
OPh-4-CO2Me H H H H O H Gb
OPh-2-CO2Et H H H H O H Ga
OPh-2-CO2Et H H H H S H G3
SPh H H H H O H Ga
SPh H H H H S H G3
SPh-2-Cl H H H H O H Ga
SPh-2-Cl H H H H S H G3
SPh-3-Cl H H H H O H Gb
SPh-4-Cl H H H H O H Gb
SPh-2-F H H H H O H Ga
SPh-2-F H H H H S H G3
SPh-3-F H H H H O H Gb
SPh-4-F H H H H O H Gb
SPh-2-CF3 H H H H O H Ga
SPh-2-CF3 H H H H S H G3
SPh-3-CF3 H H H H O H Gb
SPh-4-CF3 H H H H O H Gb
SPh-2-Me H H H H O H Ga
SPh-2-Me H H H H S H G3
SPh-3-Me H H H H O H Gb
SPh-4-Me H H H H O H Gb
SPh-2-Et H H H H O H Ga
SPh-2-Et H H H H S H G3
SPh-2-OMe H H H H O H Ga
SPh-2-OMe H H H H S H G3
SPh-3-OMe H H H H O H Gb
SPh-4-OMe H H H H O H Gb
SPh-2-OEt H H H H O H Ga
R1 R2 R3 R4 R5 X M Gn
SPh-2-OEt H H H H S H G3
SPh-2-CO2Me H H H H O H G3
SPh-2-CO2Me H H H H S H G3
SPh-3-CO2Me H H H H O H Gb
SPh-4-CO2Me H H H H O H Gb
SPh-2-CO2Et H H H H O H Ga
SPh-2-CO2Et H H H H S H G3
SO2Ph H H H H O H Ga
SO2Ph H H H H S H G3
SO2Ph-2-Cl H H H H O H Ga
SO2Ph-2-Cl H H H H S H G3
SO2Ph-3-Cl H H H H O H Gb
SO2Ph-4-Cl H H H H O H Gb
SO2Ph-2-F H H H H O H Ga
SO2Ph-2-F H H H H S H G3
SO2Ph-3-F H H H H O H Gb
SO2Ph-4-F H H H H O H Gb
SO2Ph-2-CF3 H H H H O H Ga
SO2Ph-2-CF3 H H H H S H G3
SO2Ph-3-CF3 H H H H O H Gb
SO2Ph-4-CF3 H H H H O H Gb
SO2Ph-2-Me H H H H O H Ga
SO2Ph-2-Me H H H H S H G3
SO2Ph-3-Me H H H H O H Gb
SO2Ph-4-Me H H H H O H Gb
SO2Ph-2-Et H H H H O H Ga
SO2Ph-2-Et H H H H S H G3
SO2Ph-2-OMe H H H H O H Ga
SO2Ph-2-OMe H H H H S H G3
SO2Ph-3-OMe H H H H O H Gb
SO2Ph-4-OMe H H H H O H Gb
SO2Ph-2-OEt H H H H O H Ga
SO2Ph-2-OEt H H H H S H G3
SO2Ph-2-CO2Me H H H H O H Ga
SO2Ph-2-CO2Me H H H H S H G3
SO2Ph-3-CO2Me H H H H O H Gb
SO2Ph-4-CO2Me H H H H O H Gb
SO2Ph-2-CO2Et H H H H O H Ga
SO2Ph-2-CO2Et H H H H S H G3
CONHMe H H H H O H Ga
R1 R2 R3 R4 R5 X M Gn
CONHMe H H H H S H G3
CONHEt H H H H O H Ga
CONHEt H H H H S H G3
CONHPr-n H H H H O H Gb
CONHPr-n H H H H S H G3
CONHPr-i H H H H O H Gb
CONHPr-i H H H H S H G3
CONHBu-n H H H H O H Gb
CONHBu-sec H H H H O H Gb
CONHBu-t H H H H O H Gb
CON(Me)2 H H H H O H Ga
CON(Me)2 H H H H S H G3
CON(Et)2 H H H H O H Ga
CON(Et)2 H H H H S H G3
CON(Pr-n)2 H H H H O H Gb
CON(Pr-n)2 H H H H S H G3
H F H H H O H Gb
H F H H H S H G3
H Cl H H H O H Gb
H Cl H H H S H G3
H Br H H H O H Gb
H Br H H H S H G3
H I H H H O H Gc
H CH＝CH2 H H H O H Gb
H CH＝CH2 H H H S H G3
H CH2CH＝CH2 H H H O H Gb
H C≡CH H H H O H Gb
H CH2C≡CH H H H O H Gb
H CH2F H H H O H Gb
H CH2F H H H S H G3
H CHF2 H H H O H Gb
H CHF2 H H H S H G3
H CN H H H O H Gb
H CN H H H S H G3
H NH2 H H H O H Gb
H NHCOMe H H H O H Gb
H CH2NH2 H H H O H Gb
H CH2NHCOMe H H H O H Gb
H CH2OCHF2 H H H O H Gb
H CH2OCHF2 H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H CF3 H H H O H Gb
H CF3 H H H S H G3
H CF3 H H H O Me Gb
H CF3 H H H O Et Gb
H CF3 H H H O CH2CH＝CH2Gb
H CF3 H H H O CH2C≡CH Gb
H NO2 H H H O H Gb
H NO2 H H H S H G3
H OMe H H H O H Ga
H OMe H H H S H G3
H OMe H H H O Me Gb
H OMe H H H O Et Gb
H OMe H H H O CH2CH＝CH2Gb
H OMe H H H O CH2C≡CH Gb
H OEt H H H O H Ga
H OEt H H H S H G3
H OPr-n H H H O H Gb
H OPr-n H H H S H G3
H SMe H H H O H Ga
H SMe H H H S H G3
H SEt H H H O H Ga
H SEt H H H S H G3
H SPr-n H H H O H Gb
H SPr-n H H H S H G3
H SBu-n H H H O H Gc
H SPen-n H H H O H Gc
H SO2Me H H H O H Ga
H SO2Me H H H S H G3
H SO2Et H H H O H Ga
H SO2Et H H H S H G3
H SO2Pr-n H H H O H Gb
H SO2Pr-n H H H S H G3
H COMe H H H O H Ga
H COMe H H H S H G3
H COEt H H H O H Ga
H COEt H H H S H G3
H COPr-n H H H O H Gb
H COPr-n H H H S H G3
H CO2H H H H O H Ga
H CO2H H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H CO2Me H H H O H Ga
H CO2Me H H H S H G3
H CO2Me H H H O Me Gb
H CO2Me H H H O Et Gb
H CO2Me H H H O CH2CH＝CH2Gb
H CO2Me H H H O CH2C≡CH Gb
H CO2Et H H H O H Ga
H CO2Et H H H S H G3
H CO2Pr-n H H H O H Gb
H CO2Pr-n H H H S H G3
H CO2Pr-i H H H O H Gb
H CO2Pr-i H H H S H G3
H CO2Bu-n H H H O H Gc
H CO2Bu-t H H H O H Gc
H CO2Bu-sec H H H O H Gc
H CO2Pen-n H H H O H Gc
H CH2Cl H H H O H Ga
H CH2Cl H H H S H G3
H CH2Br H H H O H Gb
H CH2Br H H H S H G3
H CH2I H H H O H Gb
H CH2I H H H S H G3
H CH2CF3 H H H O H Gb
H CH2CF3 H H H S H G3
H CH2CN H H H O H Ga
H CH2CN H H H S H G3
H CH2OH H H H O H Gb
H CH2OH H H H S H G3
H CH2OMe H H H O H Ga
H CH2OMe H H H S H G3
H CH2OMe H H H O Me Gb
H CH2OMe H H H O Et Gb
H CH2OMe H H H O CH2CH＝CH2Gb
H CH2OMe H H H O CH2C≡CH Gb
H CH2OEt H H H O H Ga
H CH2OEt H H H S H G3
H CH2OPr-n H H H O H Gb
H CH2OPr-n H H H S H G3
H CH2OPr-i H H H O H Gb
H CH2OPr-i H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H CH2SMe H H H O H Ga
H CH2SMe H H H S H G3
H CH2SEt H H H O H Ga
H CH2SEt H H H S H G3
H CH2SO2Me H H H O H Ga
H CH2SO2Et H H H O H Ga
H CH2SO2Me H H H S H G3
H CH2SO2Et H H H S H G3
H CH2SPr-n H H H O H Gb
H CH2SPr-n H H H S H G3
H CH2SPr-i H H H O H Gb
H CH2SPr-i H H H S H G3
H CH2COMe H H H O H Ga
H CH2COMe H H H S H G3
H CH2COEt H H H O H Ga
H CH2COEt H H H S H G3
H CH2COPr-n H H H O H Gb
H CH2COPr-n H H H S H G3
H CH2COPr-i H H H O H Gb
H CH2COPr-i H H H S H G3
H CH2CO2H H H H O H Ga
H CH2CO2H H H H S H G3
H CH2CO2Me H H H O H Ga
H CH2CO2Me H H H S H G3
H CH2CO2Et H H H O H Ga
H CH2CO2Et H H H S H G3
H CH2CO2Pr-n H H H O H Gb
H CH2CO2Pr-n H H H S H G3
H GH2CO2Pr-i H H H O H Gb
H CH2CO2Pr-i H H H S H G3
H CH2OCH2CH＝CH2 H H H O H Gb
H CH2OCH2CH＝CH2 H H H S H G3
H CH2OCH2C≡CH H H H O H Gb
H CH2OCH2C≡CH H H H S H G3
H CH＝CHCO2Me H H H O H Ga
H CH＝CHCO2Me H H H S H G3
H CH＝CHCO2Et H H H O H Ga
H CH＝CHCO2Et H H H S H G3
H CH＝CHCO2Pr-n H H H O H Gb
H CH＝CHCO2Pr-n H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H CH＝CHCO2Pr-i H H H O H Gb
H CH＝CHCO2Pr-i H H H S H G3
H CH＝CHCN H H H O H Ga
H CH＝CHCN H H H S H G3
H Ph H H H O H Ga
H Ph H H H S H G3
H Ph H H H O Me Gb
H Ph H H H O Et Gb
H Ph H H H O CH2CH＝CH2Gb
H Ph H H H O CH2C≡CH Gb
H Ph-2-F H H H O H Ga
H Ph-2-F H H H S H G3
H Ph-3-F H H H O H Gb
H Ph-4-F H H H O H Gb
H Ph-2-Cl H H H O H Ga
H Ph-2-Cl H H H S H G3
H Ph-3-Cl H H H O H Gb
H Ph-4-Cl H H H O H Gb
H Ph-2-Br H H H O H Ga
H Ph-2-Br H H H S H G3
H Ph-3-Br H H H O H Gb
H Ph-4-Br H H H O H Gb
H Ph-2-CF3 H H H O H Ga
H Ph-2-CF3 H H H S H G3
H Ph-3-CF3 H H H O H Gb
H Ph-4-GF3 H H H O H Gb
H Ph-2-Me H H H O H Ga
H Ph-2-Me H H H S H G3
H Ph-3-Me H H H O H Gb
H Ph-4-Me H H H O H Gb
H Ph-2-Et H H H O H Ga
H Ph-2-Et H H H S H G3
H Ph-2-OMe H H H O H Ga
H Ph-2-OMe H H H S H G3
H Ph-3-OMe H H H O H Gb
H Ph-4-OMe H H H O H Gb
H Ph-2-OEt H H H O H Ga
H Ph-2-OEt H H H S H G3
H Ph-2-CO2Me H H H O H Ga
H Ph-2-CO2Me H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H Ph-2-CO2Et H H H O H Ga
H Ph-2-CO2Et H H H S H G3
H Ph-3-CO2Me H H H O H Gb
H Ph-4-CO2Me H H H O H Gb
H CH2Ph H H H O H Ga
H CH2Ph H H H S H G3
H CH2Ph H H H O Me Gb
H CH2Ph H H H O Et Gb
H CH2Ph H H H O CH2CH＝CH2Gb
H CH2Ph H H H O CH2C≡CH Gb
H CH2Ph-2-F H H H O H Ga
H CH2Ph-2-F H H H S H G3
H CH2Ph-3-F H H H O H Gb
H CH2Ph-4-F H H H O H Gb
H CH2Ph-2-Cl H H H O H Ga
H CH2Ph-2-Cl H H H S H G3
H CH2Ph-3-Gl H H H O H Gb
H CH2Ph-4-Cl H H H O H Gb
H CH2Ph-2-Br H H H O H Ga
H CH2Ph-2-Br H H H S H G3
H CH2Ph-3-Br H H H O H Gb
H CH2Ph-4-Br H H H O H Gb
H CH2Ph-2-CF3 H H H O H Ga
H CH2Ph-2-CF3 H H H S H G3
H CH2Ph-3-CF3 H H H O H Gb
H CH2Ph-4-CF3 H H H O H Gb
H CH2Ph-2-Me H H H O H Ga
H CH2Ph-2-Me H H H S H G3
H CH2Ph-3-Me H H H O H Gb
H CH2Ph-4-Me H H H O H Gb
H CH2Ph-2-Et H H H O H Ga
H CH2Ph-2-Et H H H S H G3
H CH2Ph-2-OMe H H H O H Ga
H CH2Ph-2-OMe H H H S H G3
H CH2Ph-3-OMe H H H O H Gb
H CH2Ph-4-OMe H H H O H Gb
H CH2Ph-2-OEt H H H O H Ga
H CH2Ph-2-OEt H H H S H G3
H CH2Ph-2-CO2Me H H H O H Ga
H CH2Ph-2-CO2Me H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H CH2Ph-2-CO2Et H H H O H Ga
H CH2Ph-2-CO2Et H H H S H G3
H CH2Ph-3-CO2Me H H H O H Gb
H CH2Ph-4-CO2Me H H H O H Gb
H OPh H H H O H Ga
H OPh H H H S H G3
H OPh H H H O Me Gb
H OPh H H H O Et Gb
H OPh H H H O CH2CH＝CH2Gb
H OPh H H H O CH2C≡CH Gb
H OPh-2-Cl H H H O H Ga
H OPh-2-Cl H H H S H G3
H OPh-3-Cl H H H O H Gb
H OPh-4-Cl H H H O H Gb
H OPh-2-F H H H O H Ga
H OPh-2-F H H H S H G3
H OPh-3-F H H H O H Gb
H OPh-4-F H H H O H Gb
H OPh-2-CF3 H H H O H Ga
H OPh-2-CF3 H H H S H G3
H OPh-3-CF3 H H H O H Gb
H OPh-4-CF3 H H H O H Gb
H OPh-2-Me H H H O H Ga
H OPh-2-Me H H H S H G3
H OPh-3-Me H H H O H Gb
H OPh-4-Me H H H O H Gb
H OPh-2-Et H H H O H Ga
H OPh-2-Et H H H S H G3
H OPh-2-OMe H H H O H Ga
H OPh-2-OMe H H H S H G3
H OPh-3-OMe H H H O H Gb
H OPh-4-OMe H H H O H Gb
H OPh-2-OEt H H H O H Ga
H OPh-2-OEt H H H S H G3
H OPh-2-CO2Me H H H O H Ga
H OPh-2-CO2Me H H H S H G3
H OPh-3-CO2Me H H H O H Gb
H OPh-4-CO2Me H H H O H Gb
H OPh-2-CO2Et H H H O H Ga
H OPh-2-CO2Et H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H SPh H H H O H Ga
H SPh H H H S H G3
H SPh-2-Cl H H H O H Ga
H SPh-2-Cl H H H S H G3
H SPh-3-Cl H H H O H Gb
H SPh-4-Cl H H H O H Gb
H SPh-2-F H H H O H Ga
H SPh-2-F H H H S H G3
H SPh-3-F H H H O H Gb
H SPh-4-F H H H O H Gb
H SPh-2-CF3 H H H O H Ga
H SPh-2-CF3 H H H S H G3
H SPh-3-CF3 H H H O H Gb
H SPh-4-CF3 H H H O H Gb
H SPh-2-Me H H H O H Ga
H SPh-2-Me H H H S H G3
H SPh-3-Me H H H O H Gb
H SPh-4-Me H H H O H Gb
H SPh-2-Et H H H O H Ga
H SPh-2-Et H H H S H G3
H SPh-2-OMe H H H O H Ga
H SPh-2-OMe H H H S H G3
H SPh-3-OMe H H H O H Gb
H SPh-4-OMe H H H O H Gb
H SPh-2-OEt H H H O H Ga
H SPh-2-OEt H H H S H G3
H SPh-2-CO2Me H H H O H G3
H SPh-2-CO2Me H H H S H G3
H SPh-3-CO2Me H H H O H Gb
H SPh-4-CO2Me H H H O H Gb
H SPh-2-CO2Et H H H O H Ga
H SPh-2-CO2Et H H H S H G3
H SO2Ph H H H O H Ga
H SO2Ph H H H S H G3
H SO2Ph-2-Cl H H H O H Ga
H SO2Ph-2-Cl H H H S H G3
H SO2Ph-3-Cl H H H O H Gb
H SO2Ph-4-Cl H H H O H Gb
H SO2Ph-2-F H H H O H Ga
H SO2Ph-2-F H H H S H G3
R1 R2 R3 R4 R5 X M Gn
H SO2Ph-3-F H H H O H Gb
H SO2Ph-4-F H H H O H Gb
H SO2Ph-2-CF3 H H H O H Ga
H SO2Ph-2-CF3 H H H S H G3
H SO2Ph-3-CF3 H H H O H Gb
H SO2Ph-4-CF3 H H H O H Gb
H SO2Ph-2-Me H H H O H Ga
H SO2Ph-2-Me H H H S H G3
H SO2Ph-3-Me H H H O H Gb
H SO2Ph-4-Me H H H O H Gb
H SO2Ph-2-Et H H H O H Ga
H SO2Ph-2-Et H H H S H G3
H SO2Ph-2-OMe H H H O H Ga
H SO2Ph-2-OMe H H H S H G3
H SO2Ph-3-OMe H H H O H Gb
H SO2Ph-4-OMe H H H O H Gb
H SO2Ph-2-OEt H H H O H Ga
H SO2Ph-2-OEt H H H S H G3
H SO2Ph-2-CO2Me H H H O H Ga
H SO2Ph-2-CO2Me H H H S H G3
H SO2Ph-3-CO2Me H H H O H Gb
H SO2Ph-4-CO2Me H H H O H Gb
H SO2Ph-2-CO2Et H H H O H Ga
H SO2Ph-2-CO2Et H H H S H G3
H CONHMe H H H O H Ga
H CONHMe H H H S H G3
H CONHEt H H H O H Ga
H CONHEt H H H S H G3
H CONHPr-n H H H O H Gb
H CONHPr-n H H H S H G3
H CONHPr-i H H H O H Gb
H CONHPr-i H H H S H G3
H CONHBu-n H H H O H Gb
H CONHBu-sec H H H O H Gb
H CONHBu-t H H H O H Gb
H CON(Me)2 H H H O H Ga
H CON(Me)2 H H H S H G3
H CON(Et)2 H H H O H Ga
H CON(Et)2 H H H S H G3
H CON(Pr-n)2 H H H O H Gb
R1 R2 R3 R4 R5 X M Gn
H CON(Pr-n)2 H H H S H G3
H H F H H O H Gb
H H F H H S H G3
H H Cl H H O H Gb
H H Cl H H S H G3
H H Br H H O H Gb
H H Br H H S H G3
H H I H H O H Gc
H H CH＝CH2 H H O H Gb
H H CH＝CH2 H H S H G3
H H CH2CH＝CH2 H H O H Gb
H H C≡CH H H O H Gb
H H CH2C≡CH H H O H Gb
H H CH2F H H O H Gb
H H CH2F H H S H G3
H H CHF2 H H O H Gb
H H CHF2 H H S H G3
H H CN H H O H Gb
H H CN H H S H G3
H H NH2 H H O H Gb
H H NHCOMe H H O H Gb
H H CH2NH2 H H O H Gb
H H CH2NHCOMe H H O H Gb
H H CH2OCHF2 H H O H Gb
H H CH2OCHF2 H H S H G3
H H CF3 H H O H Gb
H H CF3 H H S H G3
H H CF3 H H O Me Gb
H H CF3 H H O Et Gb
H H CF3 H H O CH2CH＝CH2Gb
H H CF3 H H O CH2C≡CH Gb
H H NO2 H H O H Gb
H H NO2 H H S H G3
H H OMe H H O H Ga
H H OMe H H S H G3
H H OMe H H O Me Gb
H H OMe H H O Et Gb
H H OMe H H O CH2CH＝CH2Gb
H H OMe H H O CH2C≡CH Gb
H H OEt H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H OEt H H S H G3
H H OPr-n H H O H Gb
H H OPr-n H H S H G3
H H SMe H H O H Ga
H H SMe H H S H G3
H H SEt H H O H Ga
H H SEt H H S H G3
H H SPr-n H H O H Gb
H H SPr-n H H S H G3
H H SBu-n H H O H Gc
H H SPen-n H H O H Gc
H H SO2Me H H O H Ga
H H SO2Me H H S H G3
H H SO2Et H H O H Ga
H H SO2Et H H S H G3
H H SO2Pr-n H H O H Gb
H H SO2Pr-n H H S H G3
H H COMe H H O H Ga
H H COMe H H S H G3
H H COEt H H O H Ga
H H COEt H H S H G3
H H COPr-n H H O H Gb
H H COPr-n H H S H G3
H H CO2H H H O H Ga
H H CO2H H H S H G3
H H CO2Me H H O H Ga
H H CO2Me H H S H G3
H H CO2Me H H O Me Gb
H H CO2Me H H O Et Gb
H H CO2M H H O CH2CH＝CH2Gb
H H CO2Me H H O CH2C≡CH Gb
H H CO2Et H H O H Ga
H H CO2Et H H S H G3
H H CO2Pr-n H H O H Gb
H H CO2Pr-n H H S H G3
H H CO2Pr-i H H O H Gb
H H CO2Pr-i H H S H G3
H H CO2Bu-n H H O H Gc
H H CO2Bu-t H H O H Gc
H H CO2Bu-sec H H O H Gc
R1 R2 R3 R4 R5 X M Gn
H H CO2Pen-n H H O H Gc
H H CH2Cl H H O H Ga
H H CH2Cl H H S H G3
H H CH2Br H H O H Gb
H H CH2Br H H S H G3
H H CH2I H H O H Gb
H H CH2I H H S H G3
H H CH2CF3 H H O H Gb
H H CH2CF3 H H S H G3
H H CH2CN H H O H Ga
H H CH2CN H H S H G3
H H CH2OH H H O H Gb
H H CH2OH H H S H G3
H H CH2OMe H H O H Ga
H H CH2OMe H H S H G3
H H CH2OMe H H O Me Gb
H H CH2OMe H H O Et Gb
H H CH2OMe H H O CH2CH＝CH2Gb
H H CH2OMe H H O CH2C≡CH Gb
H H CH2OEt H H O H Ga
H H CH2OEt H H S H G3
H H CH2OPr-n H H O H Gb
H H CH2OPr-n H H S H G3
H H CH2OPr-i H H O H Gb
H H CH2OPr-i H H S H G3
H H CH2SMe H H O H Ga
H H CH2SMe H H S H G3
H H CH2SEt H H O H Ga
H H CH2SEt H H S H G3
H H CH2SO2Me H H O H Ga
H H CH2SO2Et H H O H Ga
H H CH2SO2Me H H S H G3
H H CH2SO2Et H H S H G3
H H CH2SPr-n H H O H Gb
H H CH2SPr-n H H S H G3
H H CH2SPr-i H H O H Gb
H H CH2SPr-i H H S H G3
H H CH2COMe H H O H Ga
H H CH2COMe H H S H G3
H H CH2COEt H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H CH2COEt H H S H G3
H H CH2COPr-n H H O H Gb
H H CH2COPr-n H H S H G3
H H CH2COPr-i H H O H Gb
H H CH2COPr-i H H S H G3
H H CH2CO2H H H O H Ga
H H CH2CO2H H H S H G3
H H CH2CO2Me H H O H Ga
H H CH2CO2Me H H S H G3
H H CH2CO2Et H H O H Ga
H H CH2CO2Et H H S H G3
H H CH2CO2Pr-n H H O H Gb
H H CH2CO2Pr-n H H S H G3
H H CH2CO2Pr-i H H O H Gb
H H CH2CO2Pr-i H H S H G3
H H CH2OCH2CH＝CH2 H H O H Gb
H H CH2OCH2CH＝CH2 H H S H G3
H H CH2OCH2C≡CH H H O H Gb
H H CH2OCH2C≡CH H H S H G3
H H CH＝CHCO2Me H H O H Ga
H H CH＝CHCO2Me H H S H G3
H H CH＝CHCO2Et H H O H Ga
H H CH＝CHCO2Et H H S H G3
H H CH＝CHCO2Pr-n H H O H Gb
H H CH＝CHCO2Pr-n H H S H G3
H H CH＝CHCO2Pr-i H H O H Gb
H H CH＝CHCO2Pr-i H H S H G3
H H CH＝CHCN H H O H Ga
H H CH＝CHCN H H S H G3
H H Ph H H O H Ga
H H Ph H H S H G3
H H Ph H H O Me Gb
H H Ph H H O Et Gb
H H Ph H H O CH2CH＝CH2Gb
H H Ph H H O CH2C≡CH Gb
H H Ph-2-F H H O H Ga
H H Ph-2-F H H S H G3
H H Ph-3-F H H O H Gb
H H Ph-4-F H H O H Gb
H H Ph-2-Cl H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H Ph-2-Cl H H S H G3
H H Ph-3-Cl H H O H Gb
H H Ph-4-Cl H H O H Gb
H H Ph-2-Br H H O H Ga
H H Ph-2-Br H H S H G3
H H Ph-3-Br H H O H Gb
H H Ph-4-Br H H O H Gb
H H Ph-2-CF2 H H O H Ga
H H Ph-2-CF3 H H S H G3
H H Ph-3-CF3 H H O H Gb
H H Ph-4-CF3 H H O H Gb
H H Ph-2-Me H H O H Ga
H H Ph-2-Me H H S H G3
H H Ph-3-Me H H O H Gb
H H Ph-4-Me H H O H Gb
H H Ph-2-Et H H O H Ga
H H Ph-2-Et H H S H G3
H H Ph-2-OMe H H O H Ga
H H Ph-2-OMe H H S H G3
H H Ph-3-OMe H H O H Gb
H H Ph-4-OMe H H O H Gb
H H Ph-2-OEt H H O H Ga
H H Ph-2-OEt H H S H G3
H H Ph-2-CO2Me H H O H Ga
H H Ph-2-CO2Me H H S H G3
H H Ph-2-CO2Et H H O H Ga
H H Ph-2-CO2Et H H S H G3
H H Ph-3-CO2Me H H O H Gb
H H Ph-4-CO2Me H H O H Gb
H H CH2Ph H H O H Ga
H H CH2Ph H H S H G3
H H CH2Ph H H O Me Gb
H H CH2Ph H H O Et Gb
H H CH2Ph H H O CH2CH＝CH2Gb
H H CH2Ph H H O CH2C≡CH Gb
H H CH2Ph-2-F H H O H Ga
H H CH2Ph-2-F H H S H G3
H H CH2Ph-3-F H H O H Gb
H H CH2Ph-4-F H H O H Gb
H H CH2Ph-2-Cl H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H CH2Ph-2-Cl H H S H G3
H H CH2Ph-3-Cl H H O H Gb
H H CH2Ph-4-Cl H H O H Gb
H H CH2Ph-2-Br H H O H Ga
H H CH2Ph-2-Br H H S H G3
H H CH2Ph-3-Br H H O H Gb
H H CH2Ph-4-Br H H O H Gb
H H CH2Ph-2-CF3 H H O H Ga
H H CH2Ph-2-CF3 H H S H G3
H H CH2Ph-3-CF3 H H O H Gb
H H CH2Ph-4-CF3 H H O H Gb
H H CH2Ph-2-Me H H O H Ga
H H CH2Ph-2-Me H H S H G3
H H CH2Ph-3-Me H H O H Gb
H H CH2Ph-4-Me H H O H Gb
H H CH2Ph-2-Et H H O H Ga
H H CH2Ph-2-Et H H S H G3
H H CH2Ph-2-OMe H H O H Ga
H H CH2Ph-2-OMe H H S H G3
H H CH2Ph-3-OMe H H O H Gb
H H CH2Ph-4-OMe H H O H Gb
H H CH2Ph-2-OEt H H O H Ga
H H CH2Ph-2-OEt H H S H G3
H H CH2Ph-2-CO2Me H H O H Ga
H H CH2Ph-2-CO2Me H H S H G3
H H CH2Ph-2-CO2Et H H O H Ga
H H CH2Ph-2-CO2Et H H S H G3
H H CH2Ph-3-CO2Me H H O H Gb
H H CH2Ph-4-CO2Me H H O H Gb
H H OPh H H O H Ga
H H OPh H H S H G3
H H OPh H H O Me Gb
H H OPh H H O Et Gb
H H OPh H H O CH2CH＝CH2Gb
H H OPh H H O CH2C≡CH Gb
H H OPh-2-Cl H H O H Ga
H H OPh-2-Cl H H S H G3
H H OPh-3-Cl H H O H Gb
H H OPh-4-Cl H H O H Gb
H H OPh-2-F H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H OPh-2-F H H S H G3
H H OPh-3-F H H O H Gb
H H OPh-4-F H H O H Gb
H H OPh-2-CF3 H H O H Ga
H H OPh-2-CF3 H H S H G3
H H OPh-3-CF3 H H O H Gb
H H OPh-4-CF3 H H O H Gb
H H OPh-2-Me H H O H Ga
H H OPh-2-Me H H S H G3
H H OPh-3-Me H H O H Gb
H H OPh-4-Me H H O H Gb
H H OPh-2-Et H H O H Ga
H H OPh-2-Et H H S H G3
H H OPh-2-OMe H H O H Ga
H H OPh-2-OMe H H S H G3
H H OPh-3-OMe H H O H Gb
H H OPh-4-OMe H H O H Gb
H H OPh-2-OEt H H O H Ga
H H OPh-2-OEt H H S H G3
H H OPh-2-CO2Me H H O H Ga
H H OPh-2-CO2Me H H S H G3
H H OPh-3-CO2Me H H O H Gb
H H OPh-4-CO2Me H H O H Gb
H H OPh-2-CO2Et H H O H Ga
H H OPh-2-CO2Et H H S H G3
H H SPh H H O H Ga
H H SPh H H S H G3
H H SPh-2-Cl H H O H Ga
H H SPh-2-Cl H H S H G3
H H SPh-3-Cl H H O H Gb
H H SPh-4-Cl H H O H Gb
H H SPh-2-F H H O H Ga
H H SPh-2-F H H S H G3
H H SPh-3-F H H O H Gb
H H SPh-4-F H H O H Gb
H H SPh-2-CF3 H H O H Ga
H H SPh-2-CF3 H H S H G3
H H SPh-3-CF3 H H O H Gb
H H SPh-4-CF3 H H O H Gb
H H SPh-2-Me H H O H Ga
R1 R2 R3 R4 R5 X M Gn
H H SPh-2-Me H H S H G3
H H SPh-3-Me H H O H Gb
H H SPh-4-Me H H O H Gb
H H SPh-2-Et H H O H Ga
H H SPh-2-Et H H S H G3
H H SPh-2-OMe H H O H Ga
H H SPh-2-OMe H H S H G3
H H SPh-3-OMe H H O H Gb
H H SPh-4-OMe H H O H Gb
H H SPh-2-OEt H H O H Ga
H H SPh-2-OEt H H S H G3
H H SPh-2-CO2Me H H O H G3
H H SPh-2-CO2Me H H S H G3
H H SPh-3-CO2Me H H O H Gb
H H SPh-4-CO2Me H H O H Gb
H H SPh-2-CO2Et H H O H Ga
H H SPh-2-CO2Et H H S H G3
H H SO2Ph H H O H Ga
H H SO2Ph H H S H G3
H H SO2Ph-2-Cl H H O H Ga
H H SO2Ph-2-Cl H H S H G3
H H SO2Ph-3-Cl H H O H Gb
H H SO2Ph-4-Cl H H O H Gb
H H SO2Ph-2-F H H O H Ga
H H SO2Ph-2-F H H S H G3
H H SO2Ph-3-F H H O H Gb
H H SO2Ph-4-F H H O H Gb
H H SO2Ph-2-CF3 H H O H Ga
H H SO2PH-2-CF3 H H S H G3
H H SO2Ph-3-CF3 H H O H Gb
H H SO2Ph-4-CF3 H H O H Gb
H H SO2Ph-2-Me H H O H Ga
H H SO2Ph-2-Me H H S H G3
H H SO2Ph-3-Me H H O H Gb
H H SO2Ph-4-Me H H O H Gb
H H SO2Ph-2-Et H H O H Ga
H H SO2Ph-2-Et H H S H G3
H H SO2Ph-2-OMe H H O H Ga
H H SO2Ph-2-OMe H H S H G3
H H SO2Ph-3-OMe H H O H Gb
R1 R2 R3 R4 R5 X M Gn
H H SO2Ph-4-OMe H H O H Gb
H H SO2Ph-2-OEt H H O H Ga
H H SO2Ph-2-OEt H H S H G3
H H SO2Ph-2-CO2Me H H O H Ga
H H SO2Ph-2-CO2Me H H S H G3
H H SO2Ph-3-CO2Me H H O H Gb
H H SO2Ph-4-CO2Me H H O H Gb
H H SO2Ph-2-CO2Et H H O H Ga
H H SO2Ph-2-CO2Et H H S H G3
H H CONHMe H H O H Ga
H H CONHMe H H S H G3
H H CONHEt H H O H Ga
H H CONHEt H H S H G3
H H CONHPr-n H H O H Gb
H H CONHPr-n H H S H G3
H H CONHPr-i H H O H Gb
H H CONHPr-i H H S H G3
H H CONHBu-n H H O H Gb
H H CONHBu-sec H H O H Gb
H H CONHBu-t H H O H Gb
H H CON(Me)2 H H O H Ga
H H CON(Me)2 H H S H G3
H H CON(Et)2 H H O H Ga
H H CON(Et)2 H H S H G3
H H CON(Pr-n)2 H H O H Gb
H H CON(Pr-n)2 H H S H G3
R1 R2 R3 R4 R5 X M Gn
Me Me H H H O H Ga
Me Me H H H S H G3
Me H Me H H O H Ga
Me H Me H H S H G3
Me H H Me H O H Ga
Me H H Me H S H G3
Me Et H H H O H Gb
Me H Et H H O H Gb
Me H H Et H O H Gb
He Pr-n H H H O H Gb
Me H Pr-n H H O H Gb
Me H H Pr-n H O H Gb
Me Pr-i H H H O H Gb
Me H Pr-i H H O H Gb
Me H H Pr-i H O H Gb
Et Me H H H O H Ga
Et Me H H H S H G3
Et H Me H H O H Ga
Et H Me H H S H G3
Et H H Me H O H Ga
Et H H Me H S H G3
Et Et H H H O H Gb
Et H Et H H O H Gb
Et H H Et H O H Gb
Et Pr-n H H H O H Gb
Et H Pr-n H H O H Gb
Et H H Pr-n H O H Gb
Et Pr-i H H H O H Gb
Et H Pr-i H H O H Gb
Et H H Pr-i H O H Gb
Pr-n Me H H H O H Ga
Pr-n Me H H H S H G3
Pr-n H Me H H O H Ga
Pr-n H Me H H S H G3
Pr-n H H Me H O H Ga
Pr-n H H Me H S H G3
Pr-n Et H H H O H Gb
Pr-n H Et H H O H Gb
Pr-n H H Et H O H Gb
Pr-n Pr-n H H H O H Gb
R1 R2 R3 R4 R5 X M Gn
Pr-n H Pr-n H H O H Gb
Pr-n H H Pr-n H O H Gb
Pr-n Pr-i H H H O H Gb
Pr-n H Pr-i H H O H Gb
Pr-n H H Pr-i H O H Gb
Pr-i Me H H H O H Ga
Pr-i Me H H H S H G3
Pr-i H Me H H O H Ga
Pr-i H Me H H S H G3
Pr-i H H Me H O H Ga
Pr-i H H Me H S H G3
Pr-i Et H H H O H Gb
Pr-i H Et H H O H Gb
Pr-i H H Et H O H Gb
Pr-i Pr-n H H H O H Gb
Pr-i H Pr-n H H O H Gb
Pr-i H H Pr-n H O H Gb
Pr-i Pr-i H H H O H Gb
Pr-i H Pr-i H H O H Gb
Pr-i H H Pr-i H O H Gb
H Me Me H H O H Ga
H Me Me H H S H G3
H Me H Me H O H Ga
H Me H Me H S H G3
H Me Et H H O H Gb
H Me Et H H S H G3
H Me H Et H O H Gb
H Me H Et H S H G3
H Me Pr-n H H O H Gb
H Me Pr-i H H O H Gb
H Me H Pr-n H O H Gb
H Me H Pr-i H O H Gb
H Et Me H H O H Ga
H Et Me H H S H G3
H Et H Me H O H Ga
H Et H Me H S H G3
H Et Et H H O H Gb
H Et Et H H S H G3
H Et H Et H O H Gb
H Et H Et H S H G3
R1 R2 R3 R4 R5 X M Gn
H Et Pr-n H H O H Gb
H Et Pr-i H H O H Gb
H Et H Pr-n H O H Gb
H Et H Pr-i H O H Gb
H Pr-n Me H H O H Ga
H Pr-n Me H H S H G3
H Pr-n H Me H O H Ga
H Pr-n H Me H S H G3
H Pr-n Et H H O H Gb
H Pr-n Et H H S H G3
H Pr-n H Et H O H Gb
H Pr-n H Et H S H G3
H Pr-n Pr-n H H O H Gb
H Pr-n Pr-i H H O H Gb
H Pr-n H Pr-n H O H Gb
H Pr-n H Pr-i H O H Gb
H Pr-i Me H H O H Ga
H Pr-i Me H H S H G3
H Pr-i H Me H O H Ga
H Pr-i H Me H S H G3
H Pr-i Et H H O H Gb
H Pr-i Et H H S H G3
H Pr-i H Et H O H Gb
H Pr-i H Et H S H G3
H Pr-i Pr-n H H O H Gb
H Pr-i Pr-i H H O H Gb
H Pr-i H Pr-n H O H Gb
H Pr-i H Pr-i H O H Gb
H H Me Me H O H Ga
H H Me Me H S H G3
H H Me Et H O H Gb
H H Me Pr-n H O H Gb
H H Me Pr-i H O H Gb
H H Et Me H O H Ga
H H Et Me H S H G3
H H Et Et H O H Gb
H H Et Pr-n H O H Gb
H H Et Pr-i H O H Gb
H H Pr-n Me H O H Ga
H H Pr-n Me H S H G3
R1 R2 R3 R4 R5 X M Gn
H H Pr-n Et H O H Gb
H H Pr-n Pr-n H O H Gb
H H Pr-n Pr-i H O H Gb
H H Pr-i Me H O H Ga
H H Pr-i Me H S H G3
H H Pr-i Et H O H Gb
H H Pr-i Pr-n H O H Gb
H H Pr-i Pr-i H O H Gb
Me Me Me H H O H Gb
Me Me Et H H O H Gb
Me Me Pr-n H H O H Gc
Me Me Pr-i H H O H Gc
Me Et Me H H O H Gb
Me Et Et H H O H Gb
Me Et Pr-n H H O H Gc
Me Et Pr-i H H O H Gc
Me Pr-n Me H H O H Gb
Me Pr-n Et H H O H Gb
Me Pr-n Pr-n H H O H Gc
Me Pr-n Pr-i H H O H Gc
Me Pr-i Me H H O H Gb
Me Pr-i Et H H O H Gb
Me Pr-i Pr-n H H O H Gc
Me Pr-i Pr-i H H O H Gc
Et Me Me H H O H Gb
Et Me Et H H O H Gb
Et Me Pr-n H H O H Gc
Et Me Pr-i H H O H Gc
Et Et Me H H O H Gb
Et Et Et H H O H Gb
Et Et Pr-n H H O H Gc
Et Et Pr-i H H O H Gc
Et Pr-n Me H H O H Gb
Et Pr-n Et H H O H Gb
Et Pr-n Pr-n H H O H Gc
Et Pr-n Pr-i H H O H Gc
Et Pr-i Me H H O H Gb
Et Pr-i Et H H O H Gb
Et Pr-i Pr-n H H O H Gc
Et Pr-i Pr-i H H O H Gc
R1 R2 R3 R4 R5 X M Gn
Pr-n Me Me H H O H Gb
Pr-n Me Et H H O H Gb
Pr-n Me Pr-n H H O H Gc
Pr-n Me Pr-i H H O H Gc
Pr-n Et Me H H O H Gb
Pr-n Et Et H H O H Gb
Pr-n Et Pr-n H H O H Gc
Pr-n Et Pr-i H H O H Gc
Pr-n Pr-n Me H H O H Gb
Pr-n Pr-n Et H H O H Gb
Pr-n Pr-n Pr-n H H O H Gc
Pr-n Pr-n Pr-i H H O H Gc
Pr-n Pr-i Me H H O H Gb
Pr-n Pr-i Et H H O H Gb
Pr-n Pr-i Pr-n H H O H Gc
Pr-n Pr-i Pr-i H H O H Gc
Pr-i Me Me H H O H Gb
Pr-i Me Et H H O H Gb
Pr-i Me Pr-n H H O H Gc
Pr-i Me Pr-i H H O H Gc
Pr-i Et Me H H O H Gb
Pr-i Et Et H H O H Gb
Pr-i Et Pr-n H H O H Gc
Pr-i Et Pr-i H H O H Gc
Pr-i Pr-n Me H H O H Gb
Pr-i Pr-n Et H H O H Gb
Pr-i Pr-n Pr-n H H O H Gc
Pr-i Pr-n Pr-i H H O H Gc
Pr-i Pr-i Me H H O H Gb
Pr-i Pr-i Et H H O H Gb
Pr-i Pr-i Pr-n H H O H Gc
Pr-i Pr-i Pr-i H H O H Gc
Me H Me Me H O H Gb
Me H Me Et H O H Gb
Me H Me Pr-n H O H Gc
Me H Me Pr-i H O H Gc
Me H Et Me H O H Gb
Me H Et Et H O H Gb
Me H Et Pr-n H O H Gc
Me H Et Pr-i H O H Gc
R1 R2 R3 R4 R5 X M Gn
Me H Pr-n Me H O H Gb
Me H Pr-n Et H O H Gb
Me H Pr-n Pr-n H O H Gc
Me H Pr-n Pr-i H O H Gc
Me H Pr-i Me H O H Gb
Me H Pr-i Et H O H Gb
Me H Pr-i Pr-n H O H Gc
Me H Pr-i Pr-i H O H Gc
Et H Me Me H O H Gb
Et H Me Et H O H Gb
Et H Me Pr-n H O H Gc
Et H Me Pr-i H O H Gc
Et H Et Me H O H Gb
Et H Et Et H O H Gb
Et H Et Pr-n H O H Gc
Et H Et Pr-i H O H Gc
Et H Pr-n Me H O H Gb
Et H Pr-n Et H O H Gb
Et H Pr-n Pr-n H O H Gc
Et H Pr-n Pr-i H O H Gc
Et H Pr-i Me H O H Gb
Et H Pr-i Et H O H Gb
Et H Pr-i Pr-n H O H Gc
Et H Pr-i Pr-i H O H Gc
Pr-n H Me Me H O H Gb
Pr-n H Me Et H O H Gb
Pr-n H Me Pr-n H O H Gc
Pr-n H Me Pr-i H O H Gc
Pr-n H Et Me H O H Gb
Pr-n H Et Et H O H Gb
Pr-n H Et Pr-n H O H Gc
Pr-n H Et Pr-i H O H Gc
Pr-n H Pr-n Me H O H Gb
Pr-n H Pr-n Et H O H Gb
Pr-n H Pr-n Pr-n H O H Gc
Pr-n H Pr-n Pr-i H O H Gc
Pr-n H Pr-i Me H O H Gb
Pr-n H Pr-i Et H O H Gb
Pr-n H Pr-i Pr-n H O H Gc
Pr-n H Pr-i Pr-i H O H Gc
R1 R2 R3 R4 R5 X M Gn
Pr-i H Me Me H O H Gb
Pr-i H Me Et H O H Gb
Pr-i H Me Pr-n H O H Gc
Pr-i H Me Pr-i H O H Gc
Pr-i H Et Me H O H Gb
Pr-i H Et Et H O H Gb
Pr-i H Et Pr-n H O H Gc
Pr-i H Et Pr-i H O H Gc
Pr-i H Pr-n Me H O H Gb
Pr-i H Pr-n Et H O H Gb
Pr-i H Pr-n Pr-n H O H Gc
Pr-i H Pr-n Pr-i H O H Gc
Pr-i H Pr-i Me H O H Gb
Pr-i H Pr-i Et H O H Gb
Pr-i H Pr-i Pr-n H O H Gc
Pr-i H Pr-i Pr-i H O H Gc
Me Me H Me H O H Gb
Me Me H Et H O H Gb
Me Me H Pr-n H O H Gc
Me Me H Pr-i H O H Gc
Me Et H Me H O H Gb
Me Et H Et H O H Gb
Me Et H Pr-n H O H Gc
Me Et H Pr-i H O H Gc
Me Pr-n H Me H O H Gb
Me Pr-n H Et H O H Gb
Me Pr-n H Pr-n H O H Gc
Me Pr-n H Pr-i H O H Gc
Me Pr-i H Me H O H Gb
Me Pr-i H Et H O H Gb
Me Pr-i H Pr-n H O H Gc
Me Pr-i H Pr-i H O H Gc
Et Me H Me H O H Gb
Et Me H Et H O H Gb
Et Me H Pr-n H O H Gc
Et Me H Pr-i H O H Gc
Et Et H Me H O H Gb
Et Et H Et H O H Gb
Et Et H Pr-n H O H Gc
Et Et H Pr-i H O H Gc
R1 R2 R3 R4 R5 X M Gn
Et Pr-n H Me H O H Gb
Et Pr-n H Et H O H Gb
Et Pr-n H Pr-n H O H Gc
Et Pr-n H Pr-i H O H Gc
Et Pr-i H Me H O H Gb
Et Pr-i H Et H O H Gb
Et Pr-i H Pr-n H O H Gc
Et Pr-i H Pr-i H O H Gc
Pr-n Me H Me H O H Gb
Pr-n Me H Et H O H Gb
Pr-n Me H Pr-n H O H Gc
Pr-n Me H Pr-i H O H Gc
Pr-n Et H Me H O H Gb
Pr-n Et H Et H O H Gb
Pr-n Et H Pr-n H O H Gc
Pr-n Et H Pr-i H O H Gc
Pr-n Pr-n H Me H O H Gb
Pr-n Pr-n H Et H O H Gb
Pr-n Pr-n H Pr-n H O H Gc
Pr-n Pr-n H Pr-i H O H Gc
Pr-n Pr-i H Me H O H Gb
Pr-n Pr-i H Et H O H Gb
Pr-n Pr-i H Pr-n H O H Gc
Pr-n Pr-i H Pr-i H O H Gc
Pr-i Me H Me H O H Gb
Pr-i Me H Et H O H Gb
Pr-i Me H Pr-n H O H Gc
Pr-i Me H Pr-i H O H Gc
Pr-i Et H Me H O H Gb
Pr-i Et H Et H O H Gb
Pr-i Et H Pr-n H O H Gc
Pr-i Et H Pr-i H O H Gc
Pr-i Pr-n H Me H O H Gb
Pr-i Pr-n H Et H O H Gb
Pr-i Pr-n H Pr-n H O H Gc
Pr-i Pr-n H Pr-i H O H Gc
Pr-i Pr-i H Me H O H Gb
Pr-i Pr-i H Et H O H Gb
Pr-i Pr-i H Pr-n H O H Gc
Pr-i Pr-i H Pr-i H O H Gc
R1 R2 R3 R4 R5 X M Gn
H Me Me Me H O H Gb
H Me Me Et H O H Gb
H Me Me Pr-n H O H Gc
H Me Me Pr-i H O H Gc
H Me Et Me H O H Gb
H Me Et Et H O H Gb
H Me Et Pr-n H O H Gc
H Me Et Pr-i H O H Gc
H Me Pr-n Me H O H Gb
H Me Pr-n Et H O H Gb
H Me Pr-n Pr-n H O H Gc
H Me Pr-n Pr-i H O H Gc
H Me Pr-i Me H O H Gb
H Me Pr-i Et H O H Gb
H Me Pr-i Pr-n H O H Gc
H Me Pr-i Pr-i H O H Gc
H Et Me Me H O H Gb
H Et Me Et H O H Gb
H Et Me Pr-n H O H Gc
H Et Me Pr-i H O H Gc
H Et Et Me H O H Gb
H Et Et Et H O H Gb
H Et Et Pr-n H O H Gc
H Et Et Pr-i H O H Gc
H Et Pr-n Me H O H Gb
H Et Pr-n Et H O H Gb
H Et Pr-n Pr-n H O H Gc
H Et Pr-n Pr-i H O H Gc
H Et Pr-i Me H O H Gb
H Et Pr-i Et H O H Gb
H Et Pr-i Pr-n H O H Gc
H Et Pr-i Pr-i H O H Gc
H Pr-n Me Me H O H Gb
H Pr-n Me Et H O H Gb
H Pr-n Me Pr-n H O H Gc
H Pr-n Me Pr-i H O H Gc
H Pr-n Et Me H O H Gb
H Pr-n Et Et H O H Gb
H Pr-n Et Pr-n H O H Gc
H Pr-n Et Pr-i H O H Gc
R1 R2 R3 R4 R5 X M Gn
H Pr-n Pr-n Me H O H Gb
H Pr-n Pr-n Et H O H Gb
H Pr-n Pr-n Pr-n H O H Gc
H Pr-n Pr-n Pr-i H O H Gc
H Pr-n Pr-i Me H O H Gb
H Pr-n Pr-i Et H O H Gb
H Pr-n Pr-i Pr-n H O H Gc
H Pr-n Pr-i Pr-i H O H Gc
H Pr-i Me Me H O H Gb
H Pr-i Me Et H O H Gb
H Pr-i Me Pr-n H O H Gc
H Pr-i Me Pr-i H O H Gc
H Pr-i Et Me H O H Gb
H Pr-i Et Et H O H Gb
H Pr-i Et Pr-n H O H Gc
H Pr-i Et Pr-i H O H Gc
H Pr-i Pr-n Me H O H Gb
H Pr-i Pr-n Et H O H Gb
H Pr-i Pr-n Pr-n H O H Gc
H Pr-i Pr-n Pr-i H O H Gc
H Pr-i Pr-i Me H O H Gb
H Pr-i Pr-i Et H O H Gb
H Pr-i Pr-i Pr-n H O H Gc
H Pr-i Pr-i Pr-i H O H Gc
Me Me Me Me H O H Gb
F H H Me H O H Gb
Cl H H Me H O H Gb
Br H H Me H O H Gb
I H H Me H O H Gc
CH＝CH2 H H Me H O H Gb
CH2CH＝CH2 H H Me H O H Gb
C≡CH H H Me H O H Gb
CH2C≡CH H H Me H O H Gb
CH2F H H Me H O H Gb
CHF2 H H Me H O H Gb
CN H H Me H O H Gb
NH2 H H Me H O H Gb
NHCOMe H H Me H O H Gb
CH2NH2 H H Me H O H Gb
CH2NHCOMe H H Me H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH2OCHF2 H H Me H O H Gb
CF3 H H Me H O H Gb
NO2 H H Me H O H Gb
OMe H H Me H O H Ga
OEt H H Me H O H Ga
OPr-n H H Me H O H Gb
SMe H H Me H O H Ga
SEt H H Me H O H Ga
SO2Me H H Me H O H Ga
COMe H H Me H O H Ga
COEt H H Me H O H Ga
CO2H H H Me H O H Ga
CO2Me H H Me H O H Ga
CO2Et H H Me H O H Ga
CO2Pr-n H H Me H O H Gb
CO2Bu-n H H Me H O H Gc
CH2Cl H H Me H O H Ga
CH2Br H H Me H O H Gb
CH2I H H Me H O H Gb
CH2CF3 H H Me H O H Gb
CH2CN H H Me H O H Ga
CH2OH H H Me H O H Gb
CH2OMe H H Me H O H Ga
CH2OEt H H Me H O H Ga
CH2OPr-n H H Me H O H Gb
CH2SMe H H Me H O H Ga
CH2SEt H H Me H O H Ga
CH2SO2Me H H Me H O H Ga
CH2SO2Et H H Me H O H Ga
CH2SPr-n H H Me H O H Gb
CH2SPr-i H H Me H O H Gb
CH2COMe H H Me H O H Ga
CH2COEt H H Me H O H Ga
CH2COPr-n H H Me H O H Gb
CH2CO2H H H Me H O H Ga
CH2CO2Me H H Me H O H Ga
CH2CO2Et H H Me H O H Ga
CH2CO2Pr-n H H Me H O H Gb
CH2OCH2CH＝CH2H H Me H O H Gb
CH2OCH2C≡CH H H Me H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH＝CHCO2Me H H Me H O H Ga
CH＝CHCO2Et H H Me H O H Ga
CH＝CHCO2Pr-n H H Me H O H Gb
CH＝CHCN H H Me H O H Ga
Ph H H Me H O H Ga
CH2Ph H H Me H O H Ga
OPh H H Me H O H Ga
SPh H H Me H O H Ga
SO2Ph H H Me H O H Ga
CONHMe H H Me H O H Ga
CONHEt H H Me H O H Ga
CON(Me)2 H H Me H O H Ga
CON(Et)2 H H Me H O H Ga
CON(Pr-n)2 H H Me H O H Gb
F H H Et H O H Gb
Cl H H Et H O H Gb
Br H H Et H O H Gb
I H H Et H O H Gc
CH＝CH2 H H Et H O H Gb
CH2CH＝CH2 H H Et H O H Gb
C≡CH H H Et H O H Gb
CH2C≡CH H H Et H O H Gb
CH2F H H Et H O H Gb
CHF2 H H Et H O H Gb
CN H H Et H O H Gb
NH2 H H Et H O H Gb
NHCOMe H H Et H O H Gb
CH2NH2 H H Et H O H Gb
CH2NHCOMe H H Et H O H Gb
CH2OCHF2 H H Et H O H Gb
CF3 H H Et H O H Gb
NO2 H H Et H O H Gb
OMe H H Et H O H Ga
OEt H H Et H O H Ga
OPr-n H H Et H O H Gb
SMe H H Et H O H Ga
SEt H H Et H O H Ga
SO2Me H H Et H O H Ga
COMe H H Et H O H Ga
COEt H H Et H O H Ga
R1 R2 R3 R4 R5 X M Gn
CO2H H H Et H O H Ga
CO2Me H H Et H O H Ga
CO2Et H H Et H O H Ga
CO2Pr-n H H Et H O H Gb
CO2Bu-n H H Et H O H Gc
CH2Cl H H Et H O H Ga
CH2Br H H Et H O H Gb
CH2I H H Et H O H Gb
CH2CF3 H H Et H O H Gb
CH2CN H H Et H O H Ga
CH2OH H H Et H O H Gb
CH2OMe H H Et H O H Ga
CH2OEt H H Et H O H Ga
CH2OPr-n H H Et H O H Gb
CH2SMe H H Et H O H Ga
CH2SEt H H Et H O H Ga
CH2SO2Me H H Et H O H Ga
CH2SO2Et H H Et H O H Ga
CH2SPr-n H H Et H O H Gb
CH2SPr-i H H Et H O H Gb
CH2COMe H H Et H O H Ga
CH2COEt H H Et H O H Ga
CH2COPr-n H H Et H O H Gb
CH2CO2H H H Et H O H Ga
CH2CO2Me H H Et H O H Ga
CH2CO2Et H H Et H O H Ga
CH2CO2Pr-n H H Et H O H Gb
CH2OCH2CH＝CH2H H Et H O H Gb
CH2OCH2C≡CH H H Et H O H Gb
CH＝CHCO2Me H H Et H O H Ga
CH＝CHCO2Et H H Et H O H Ga
CH＝CHCO2Pr-n H H Et H O H Gb
CH＝CHCN H H Et H O H Ga
Ph H H Et H O H Ga
CH2Ph H H Et H O H Ga
OPh H H Et H O H Ga
SPh H H Et H O H Ga
SO2Ph H H Et H O H Ga
CONHMe H H Et H O H Ga
CONHEt H H Et H O H Ga
R1 R2 R3 R4 R5 X M Gn
CON(Me)2 H H Et H O H Ga
CON(Et)2 H H Et H O H Ga
CON(Pr-n)2 H H Et H O H Gb
F H H Cl H O H Gb
Cl H H Cl H O H Gb
Br H H Cl H O H Gb
I H H Cl H O H Gc
CH＝CH2 H H Cl H O H Gb
CH2CH＝CH2 H H Cl H O H Gb
C≡CH H H Cl H O H Gb
CH2C≡CH H H Cl H O H Gb
CH2F H H Cl H O H Gb
CHF2 H H Cl H O H Gb
CN H H Cl H O H Gb
NH2 H H Cl H O H Gb
NHCOMe H H Cl H O H Gb
CH2NH2 H H Cl H O H Gb
CH2NHCOMe H H Cl H O H Gb
CH2OCHF2 H H Cl H O H Gb
CF3 H H Cl H O H Gb
NO2 H H Cl H O H Gb
OMe H H Cl H O H Ga
OEt H H Cl H O H Ga
OPr-n H H Cl H O H Gb
SMe H H Cl H O H Ga
SEt H H Gl H O H Ga
SO2Me H H Cl H O H Ga
COMe H H Cl H O H Ga
COEt H H Cl H O H Ga
CO2H H H Cl H O H Ga
CO2Me H H Cl H O H Ga
CO2Et H H Cl H O H Ga
CO2Pr-n H H Cl H O H Gb
CO2Bu-n H H Cl H O H Gc
CH2Cl H H Cl H O H Ga
CH2Br H H Cl H O H Gb
CH2I H H Cl H O H Gb
CH2CF3 H H Cl H O H Gb
CH2CN H H Cl H O H Ga
CH2OH H H Cl H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH2OMe H H Cl H O H Ga
CH2OEt H H Cl H O H Ga
CH2OPr-n H H Cl H O H Gb
CH2SMe H H Cl H O H Ga
CH2SEt H H Cl H O H Ga
CH2SO2Me H H Cl H O H Ga
CH2SO2Et H H Cl H O H Ga
CH2SPr-n H H Cl H O H Gb
CH2SPr-i H H Cl H O H Gb
CH2COMe H H Cl H O H Ga
CH2COEt H H Cl H O H Ga
CH2COPr-n H H Cl H O H Gb
CH2CO2H H H Cl H O H Ga
CH2CO2Me H H Cl H O H Ga
CH2CO2Et H H Cl H O H Ga
CH2CO2Pr-n H H Cl H O H Gb
CH2OCH2CH＝CH2H H Cl H O H Gb
CH2OCH2C≡CH H H Cl H O H Gb
CH＝CHCO2Me H H Cl H O H Ga
CH＝CHCO2Et H H Cl H O H Ga
CH＝CHCO2Pr-n H H Cl H O H Gb
CH＝CHCN H H Cl H O H Ga
Ph H H Cl H O H Ga
CH2Ph H H Cl H O H Ga
OPh H H Cl H O H Ga
SPh H H Cl H O H Ga
SO2Ph H H Cl H O H Ga
CONHMe H H Cl H O H Ga
CONHEt H H Cl H O H Ga
CON(Me)2 H H Cl H O H Ga
CON(Et)2 H H Cl H O H Ga
CON(Pr-n)2 H H Cl H O H Gb
F H H CO2Me H O H Gb
Cl H H CO2Me H O H Gb
Br H H CO2Me H O H Gb
I H H CO2Me H O H Gc
CH＝CH2 H H CO2Me H O H Gb
CH2CH＝CH2 H H CO2Me H O H Gb
C≡CH H H CO2Me H O H Gb
CH2C≡CH H H CO2Me H O H Gb
R1 R2 R3 R4 R5 X M Gn
CH2F H H CO2Me H O H Gb
CHF2 H H CO2Me H O H Gb
CN H H CO2Me H O H Gb
NH2 H H CO2Me H O H Gb
NHCOMe H H CO2Me H O H Gb
CH2NH2 H H CO2Me H O H Gb
CH2NHCOMe H H CO2Me H O H Gb
CH2OCHF2 H H CO2Me H O H Gb
CF3 H H CO2Me H O H Gb
NO2 H H CO2Me H O H Gb
OMe H H CO2Me H O H Ga
OEt H H CO2Me H O H Ga
OPr-n H H CO2Me H O H Gb
SMe H H CO2Me H O H Ga
SEt H H CO2Me H O H Ga
SO2Me H H CO2Me H O H Ga
COMe H H CO2Me H O H Ga
COEt H H CO2Me H O H Ga
CO2H H H CO2Me H O H Ga
CO2Me H H CO2Me H O H Ga
CO2Et H H CO2Me H O H Ga
CO2Pr-n H H CO2Me H O H Gb
CO2Bu-n H H CO2Me H O H Gc
CH2Cl H H CO2Me H O H Ga
CH2Br H H CO2Me H O H Gb
CH2I H H CO2Me H O H Gb
CH2CF3 H H CO2Me H O H Gb
CH2CN H H CO2Me H O H Ga
CH2OH H H CO2Me H O H Gb
CH2OMe H H CO2Me H O H Ga
CH2OEt H H CO2Me H O H Ga
CH2OPr-n H H CO2Me H O H Gb
CH2SMe H H CO2Me H O H Ga
CH2SEt H H CO2Me H O H Ga
CH2SO2Me H H CO2Me H O H Ga
CH2SO2Et H H CO2Me H O H Ga
CH2SPr-n H H CO2Me H O H Gb
CH2SPr-i H H CO2Me H O H Gb
CH2COMe H H CO2Me H O H Ga
CH2COEt H H CO2Me H O H Ga
R1 R2 R3 R4 R5 X M Gn
CH2COPr-n H H CO2Me H O H Gb
CH2CO2H H H CO2Me H O H Ga
CH2CO2Me H H CO2Me H O H Ga
CH2CO2Et H H CO2Me H O H Ga
CH2CO2Pr-n H H CO2Me H O H Gb
CH2OCH2CH＝CH2 H H CO2Me H O H Gb
CH2OCH2C≡CH H H CO2Me H O H Gb
CH＝CHCO2Me H H CO2Me H O H Ga
CH＝CHCO2Et H H CO2Me H O H Ga
CH＝CHCO2Pr-n H H CO2Me H O H Gb
CH＝CHCN H H CO2Me H O H Ga
Ph H H CO2Me H O H Ga
CH2Ph H H CO2Me H O H Ga
OPh H H CO2Me H O H Ga
SPh H H CO2Me H O H Ga
SO2Ph H H CO2Me H O H Ga
CONHMe H H CO2Me H O H Ga
CONHEt H H CO2Me H O H Ga
CON(Me)2 H H CO2Me H O H Ga
CON(Et)2 H H CO2Me H O H Ga
CON(Pr-n)2 H H CO2Me H O H Gb
F H H CH2Cl H O H Gb
Cl H H CH2Cl H O H Gb
Br H H CH2Cl H O H Gb
I H H CH2Cl H O H Gc
CH＝CH2 H H CH2Cl H O H Gb
CH2CH＝CH2 H H CH2Cl H O H Gb
C≡CH H H CH2Cl H O H Gb
CH2C≡CH H H CH2Cl H O H Gb
CH2F H H CH2Cl H O H Gb
CHF2 H H CH2Cl H O H Gb
CN H H CH2Cl H O H Gb
NH2 H H CH2Cl H O H Gb
NHCOMe H H CH2Cl H O H Gb
CH2NH2 H H CH2Cl H O H Gb
CH2NHCOMe H H CH2Cl H O H Gb
CH2OCHF2 H H CH2Cl H O H Gb
CF3 H H CH2Cl H O H Gb
NO2 H H CH2Cl H O H Gb
OMe H H CH2Cl H O H Ga
R1 R2 R3 R4 R5 X M Gn
OEt H H CH2Cl H O H Ga
OPr-n H H CH2Cl H O H Gb
SMe H H CH2Cl H O H Ga
SEt H H CH2Cl H O H Ga
SO2Me H H CH2Cl H O H Ga
COMe H H CH2Cl H O H Ga
COEt H H CH2Cl H O H Ga
CO2H H H CH2Cl H O H Ga
CO2Me H H CH2Cl H O H Ga
CO2Et H H CH2Cl H O H Ga
CO2Pr-n H H CH2Cl H O H Gb
CO2Bu-n H H CH2Gl H O H Gc
CH2Cl H H CH2Cl H O H Ga
CH2Br H H CH2Cl H O H Gb
CH2I H H CH2Cl H O H Gb
CH2CF3 H H CH2Cl H O H Gb
CH2CN H H CH2Cl H O H Ga
CH2OH H H CH2Cl H O H Gb
CH2OMe H H CH2Cl H O H Ga
CH2OEt H H CH2Cl H O H Ga
CH2OPr-n H H CH2Cl H O H Gb
CH2SMe H H CH2Cl H O H Ga
CH2SEt H H CH2Cl H O H Ga
CH2SO2Me H H CH2Cl H O H Ga
CH2SO2Et H H CH2Cl H O H Ga
CH2SPr-n H H CH2Cl H O H Gb
CH2SPr-i H H CH2Cl H O H Gb
CH2COMe H H CH2Cl H O H Ga
CH2COEt H H CH2Cl H O H Ga
CH2COPr-n H H CH2Cl H O H Gb
CH2CO2H H H CH2Cl H O H Ga
CH2CO2Me H H CH2Cl H O H Ga
CH2CO2Et H H CH2Cl H O H Ga
CH2CO2Pr-n H H CH2Cl H O H Gb
CH2OCH2CH＝CH2 H H CH2Cl H O H Gb
CH2OCH2C≡CH H H CH2Cl H O H Gb
CH＝CHCO2Me H H CH2Cl H O H Ga
CH＝CHCO2Et H H CH2Cl H O H Ga
CH＝CHCO2Pr-n H H CH2Cl H O H Gb
CH＝CHCN H H CH2Cl H O H Ga
R1 R2 R3 R4 R5 X M Gn
Ph H H CH2Cl H O H Ga
CH2Ph H H CH2Cl H O H Ga
OPh H H CH2Cl H O H Ga
SPh H H CH2Cl H O H Ga
SO2Ph H H CH2Cl H O H Ga
CONHMe H H CH2Cl H O H Ga
CONHEt H H CH2Cl H O H Ga
CON(Me)2 H H CH2Cl H O H Ga
CON(Et)2 H H CH2Cl H O H Ga
CON(Pr-n)2 H H CH2Cl H O H Gb
F H H CH2OMe H O H Gb
Cl H H CH2OMe H O H Gb
Br H H CH2OMe H O H Gb
I H H CH2OMe H O H Gc
CH＝CH2 H H CH2OMe H O H Gb
CH2CH＝CH2 H H CH2OMe H O H Gb
C≡CH H H CH2OMe H O H Gb
CH2C≡CH H H CH2OMe H O H Gb
CH2F H H CH2OMe H O H Gb
CHF2 H H CH2OMe H O H Gb
CN H H CH2OMe H O H Gb
NH2 H H CH2OMe H O H Gb
NHCOMe H H CH2OMe H O H Gb
CH2NH2 H H CH2OMe H O H Gb
CH2NHCOMe H H CH2OMe H O H Gb
CH2OCHF2 H H CH2OMe H O H Gb
CF3 H H CH2OMe H O H Gb
NO2 H H CH2OMe H O H Gb
OMe H H CH2OMe H O H Ga
OEt H H CH2OMe H O H Ga
OPr-n H H CH2OMe H O H Gb
SMe H H CH2OMe H O H Ga
SEt H H CH2OMe H O H Ga
SO2Me H H CH2OMe H O H Ga
COMe H H CH2OMe H O H Ga
COEt H H CH2OMe H O H Ga
CO2H H H CH2OMe H O H Ga
CO2Me H H CH2OMe H O H Ga
CO2Et H H CH2OMe H O H Ga
CO2Pr-n H H CH2OMe H O H Gb
R1 R2 R3 R4 R5 X M Gn
CO2Bu-n H H CH2OMe H O H Gc
CH2Cl H H CH2OMe H O H Ga
CH2Br H H CH2OMe H O H Gb
CH2I H H CH2OMe H O H Gb
CH2CF3 H H CH2OMe H O H Gb
CH2CN H H CH2OMe H O H Ga
CH2OH H H CH2OMe H O H Gb
CH2OMe H H CH2OMe H O H Ga
CH2OEt H H CH2OMe H O H Ga
CH2OPr-n H H CH2OMe H O H Gb
CH2SMe H H CH2OMe H O H Ga
CH2SEt H H CH2OMe H O H Ga
CH2SO2Me H H CH2OMe H O H Ga
CH2SO2Et H H CH2OMe H O H Ga
CH2SPr-n H H CH2OMe H O H Gb
CH2SPr-i H H CH2OMe H O H Gb
CH2COMe H H CH2OMe H O H Ga
CH2COEt H H CH2OMe H O H Ga
CH2COPr-n H H CH2OMe H O H Gb
CH2CO2H H H CH2OMe H O H Ga
CH2CO2Me H H CH2OMe H O H Ga
CH2CO2Et H H CH2OMe H O H Ga
CH2CO2Pr-n H H CH2OMe H O H Gb
CH2OCH2CH＝CH2H H CH2OMe H O H Gb
CH2OCH2C≡CH H H CH2OMe H O H Gb
CH＝CHCO2Me H H CH2OMe H O H Ga
CH＝CHCO2Et H H CH2OMe H O H Ga
CH＝CHCO2Pr-n H H CH2OMe H O H Gb
CH＝CHCN H H CH2OMe H O H Ga
Ph H H CH2OMe H O H Ga
CH2Ph H H CH2OMe H O H Ga
OPh H H CH2OMe H O H Ga
SPh H H CH2OMe H O H Ga
SO2Ph H H CH2OMe H O H Ga
CONHMe H H CH2OMe H O H Ga
CONHEt H H CH2OMe H O H Ga
CON(Me)2 H H CH2OMe H O H Ga
CON(Et)2 H H CH2OMe H O H Ga
CON(Pr-n)2 H H CH2OMe H O H Gb
F H H CH2SMe H O H Gb
R1 R2 R3 R4 R5 X M Gn
Cl H H CH2SMe H O H Gb
Br H H CH2SMe H O H Gb
I H H CH2SMe H O H Gc
CH＝CH2 H H CH2SMe H O H Gb
CH2CH＝CH2 H H CH2SMe H O H Gb
C≡CH H H CH2SMe H O H Gb
CH2C≡CH H H CH2SMe H O H Gb
CH2F H H CH2SMe H O H Gb
CHF2 H H CH2SMe H O H Gb
CN H H CH2SMe H O H Gb
NH2 H H CH2SMe H O H Gb
NHCOMe H H CH2SMe H O H Gb
CH2NH2 H H CH2SMe H O H Gb
CH2NHCOMe H H CH2SMe H O H Gb
CH2OCHF2 H H CH2SMe H O H Gb
CF3 H H CH2SMe H O H Gb
NO2 H H CH2SMe H O H Gb
OMe H H CH2SMe H O H Ga
OEt H H CH2SMe H O H Ga
OPr-n H H CH2SMe H O H Gb
SMe H H CH2SMe H O H Ga
SEt H H CH2SMe H O H Ga
SO2Me H H CH2SMe H O H Ga
COMe H H CH2SMe H O H Ga
COEt H H CH2SMe H O H Ga
CO2H H H CH2SMe H O H Ga
CO2Me H H CH2SMe H O H Ga
CO2Et H H CH2SMe H O H Ga
CO2Pr-n H H CH2SMe H O H Gb
CO2Bu-n H H CH2SMe H O H Gc
CH2Cl H H CH2SMe H O H Ga
CH2Br H H CH2SMe H O H Gb
CH2I H H CH2SMe H O H Gb
CH2CF3 H H CH2SMe H O H Gb
CH2CN H H CH2SMe H O H Ga
CH2OH H H CH2SMe H O H Gb
CH2OMe H H CH2SMe H O H Ga
CH2OEt H H CH2SMe H O H Ga
CH2OPr-n H H CH2SMe H O H Gb
CH2SMe H H CH2SMe H O H Ga
R1 R2 R3 R4 R5 X M Gn
CH2SEt H H CH2SMe H O H Ga
CH2SO2Me H H CH2SMe H O H Ga
CH2SO2Et H H CH2SMe H O H Ga
CH2SPr-n H H CH2SMe H O H Gb
CH2SPr-i H H CH2SMe H O H Gb
CH2COMe H H CH2SMe H O H Ga
CH2COEt H H CH2SMe H O H Ga
CH2COPr-n H H CH2SMe H O H Gb
CH2CO2H H H CH2SMe H O H Ga
CH2CO2Me H H CH2SMe H O H Ga
CH2CO2Et H H CH2SMe H O H Ga
CH2CO2Pr-n H H CH2SMe H O H Gb
CH2OCH2CH＝CH2 H H CH2SMe H O H Gb
CH2OCH2C≡CH H H CH2SMe H O H Gb
CH＝CHCO2Me H H CH2SMe H O H Ga
CH＝CHCO2Et H H CH2SMe H O H Ga
CH＝CHCO2Pr-n H H CH2SMe H O H Gb
CH＝CHCN H H CH2SMe H O H Ga
Ph H H CH2SMe H O H Ga
CH2Ph H H CH2SMe H O H Ga
OPh H H CH2SMe H O H Ga
SPh H H CH2SMe H O H Ga
SO2Ph H H CH2SMe H O H Ga
CONHMe H H CH2SMe H O H Ga
CONHEt H H CH2SMe H O H Ga
CON(Me)2 H H CH2SMe H O H Ga
CON(Et)2 H H CH2SMe H O H Ga
CON(Pr-n)2 H H CH2SMe H O H Gb
F H H CN H O H Gb
Cl H H CN H O H Gb
Br H H CN H O H Gb
I H H CN H O H Gc
CH＝CH2 H H CN H O H Gb
CH2CH＝CH2 H H CN H O H Gb
C≡CH H H CN H O H Gb
CH2C≡CH H H CN H O H Gb
CH2F H H CN H O H Gb
CHF2 H H CN H O H Gb
CN H H CN H O H Gb
NH2 H H CN H O H Gb
R1 R2 R3 R4 R5 X M Gn
NHCOMe H H CN H O H Gb
CH2NH2 H H CN H O H Gb
CH2NHCOMe H H CN H O H Gb
CH2OCHF2 H H CN H O H Gb
CF3 H H CN H O H Gb
NO2 H H CN H O H Gb
OMe H H CN H O H Ga
OEt H H CN H O H Ga
OPr-n H H CN H O H Gb
SMe H H CN H O H Ga
SEt H H CN H O H Ga
SO2He H H CN H O H Ga
SO2He H H CN H O H Ga
COMe H H CN H O H Ga
COEt H H CN H O H Ga
CO2H H H CN H O H Ga
CO2Me H H CN H O H Ga
CO2Et H H CN H O H Ga
CO2Pr-n H H CN H O H Gb
CO2Bu-n H H CN H O H Gc
CH2Cl H H CN H O H Ga
CH2Br H H CN H O H Gb
CH2I H H CN H O H Gb
CH2CF3 H H CN H O H Gb
CH2CN H H CN H O H Ga
CH2OH H H CN H O H Gb
CH2OMe H H CN H O H Ga
CH2SEt H H CN H O H Ga
CH2COPr-n H H CN H O H Ga
CH2SMe H H CN H O H Ga
CH2SEt H H CN H O H Ga
CH2SO2Me H H CN H O H Ga
CH2SO2Et H H CN H O H Ga
CH2SPr-n H H CN H O H Gb
CH2SPr-i H H CN H O H Gb
CH2COMe H H CN H O H Ga
CH2COEt H H CN H O H Ga
CH2COPr-n H H CN H O H Gb
CH2CO2H H H CN H O H Ga
CH2CO2Me H H CN H O H Ga
CH2CO2Et H H CN H O H Ga
R1 R2 R3 R4 R5 X M Gn
CH2CO2Pr-n H H CN H O H Gb
CH2OCH2CH＝CH2H H CN H O H Gb
CH2OCH2C≡CH H H CN H O H Gb
CH＝CHCO2Me H H CN H O H Ga
CH＝CHCO2Et H H CN H O H Ga
CH＝CHCO2Pr-n H H CN H O H Gb
CH＝CHCN H H CN H O H Ga
Ph H H CN H O H Ga
CH2Ph H H CN H O H Ga
OPh H H CN H O H Ga
SPh H H CN H O H Ga
SO2Ph H H CN H O H Ga
CONHMe H H CN H O H Ga
CONHEt H H CN H O H Ga
CON(Me)2 H H CN H O H Ga
CON(Et)2 H H CN H O H Ga
CON(Pr-n)2 H H CN H O H Gb
R4 R3 R2 R1 R5 X M Gn
F H H Me H O H Gb
Cl H H Me H O H Gb
Br H H Me H O H Gb
I H H Me H O H Gc
CH＝CH2 H H Me H O H Gb
CH2CH＝CH2 H H Me H O H Gb
C≡CH H H Me H O H Gb
CH2C≡CH H H Me H O H Gb
CH2F H H Me H O H Gb
CHF2 H H Me H O H Gb
CN H H Me H O H Gb
NH2 H H Me H O H Gb
NHCOMe H H Me H O H Gb
CH2NH2 H H Me H O H Gb
R4 R3 R2 R1 R5 X M Gn
CH2NHCOMe H H Me H O H Gb
CH2OCHF2 H H Me H O H Gb
CF3 H H Me H O H Gb
NO2 H H Me H O H Gb
OMe H H Me H O H Ga
OEt H H Me H O H Ga
OPr-n H H Me H O H Gb
SMe H H Me H O H Ga
SEt H H Me H O H Ga
SO2Me H H Me H O H Ga
COMe H H Me H O H Ga
COEt H H Me H O H Ga
CO2H H H Me H O H Ga
CO2Me H H Me H O H Ga
CO2Et H H Me H O H Ga
CO2Pr-n H H Me H O H Gb
CO2Bu-n H H Me H O H Gc
CH2Cl H H Me H O H Ga
CH2Br H H Me H O H Gb
CH2 H H Me H O H Gb
CH2CF3 H H Me H O H Gb
CH2CN H H Me H O H Ga
CH2OH H H Me H O H Gb
CH2OMe H H Me H O H Ga
CH2OEt H H Me H O H Ga
CH2OPr-n H H Me H O H Gb
CH2SMe H H Me H O H Ga
CH2SEt H H Me H O H Ga
CH2SO2Me H H Me H O H Ga
CH2SO2Et H H Me H O H Ga
CH2SPr-n H H Me H O H Gb
CH2SPr-i H H Me H O H Gb
CH2COMe H H Me H O H Ga
CH2COEt H H Me H O H Ga
CH2COPr-n H H Me H O H Gb
CH2CO2H H H Me H O H Ga
CH2CO2Me H H Me H O H Ga
CH2CO2Et H H Me H O H Ga
CH2CO2Pr-n H H Me H O H Gb
CH2OCH2CH＝CH2H H Me H O H Gb
R4 R3 R2 R1 R5 X M Gn
CH2OCH2C≡CH H H Me H O H Gb
CH＝CHCO2Me H H Me H O H Ga
CH＝CHCO2Et H H Me H O H Ga
CH＝CHCO2Pr-n H H Me H O H Gb
CH＝CHCN H H Me H O H Ga
Ph H H Me H O H Ga
CH2Ph H H Me H O H Ga
OPh H H Me H O H Ga
SPh H H Me H O H Ga
SO2Ph H H Me H O H Ga
CONHMe H H Me H O H Ga
CONHEt H H Me H O H Ga
CON(Me)2 H H Me H O H Ga
CON(Et)2 H H Me H O H Ga
CON(Pr-n)2 H H Me H O H Gb
F H H Et H O H Gb
Cl H H Et H O H Gb
Br H H Et H O H Gb
I H H Et H O H Gc
CH＝CH2 H H Et H O H Gb
CH2CH＝CH2 H H Et H O H Gb
C≡CH H H Et H O H Gb
CH2C≡CH H H Et H O H Gb
CH2F H H Et H O H Gb
CHF2 H H Et H O H Gb
CN H H Et H O H Gb
NH2 H H Et H O H Gb
NHCOMe H H Et H O H Gb
CH2NH2 H H Et H O H Gb
CH2NHCOMe H H Et H O H Gb
CH2OCHF2 H H Et H O H Gb
CF3 H H Et H O H Gb
NO2 H H Et H O H Gb
OMe H H Et H O H Ga
OEt H H Et H O H Ga
OPr-n H H Et H O H Gb
SMe H H Et H O H Ga
SEt H H Et H O H Ga
SO2Me H H Et H O H Ga
COMe H H Et H O H Ga
R4 R3 R2 R1 R5 X M Gn
COEt H H Et H O H Ga
CO2H H H Et H O H Ga
CO2Me H H Et H O H Ga
CO2Et H H Et H O H Ga
CO2Pr-n H H Et H O H Gb
CO2Bu-n H H Et H O H Gc
CH2Cl H H Et H O H Ga
CH2Br H H Et H O H Gb
CH2I H H Et H O H Gb
CH2CF3 H H Et H O H Gb
CH2CN H H Et H O H Ga
CH2OH H H Et H O H Gb
CH2OMe H H Et H O H Ga
CH2OEt H H Et H O H Ga
CH2OPr-n H H Et H O H Gb
CH2SMe H H Et H O H Ga
CH2SEt H H Et H O H Ga
CH2SO2Me H H Et H O H Ga
CH2SO2Et H H Et H O H Ga
CH2SPr-n H H Et H O H Gb
CH2SPr-i H H Et H O H Gb
CH2COMe H H Et H O H Ga
CH2COEt H H Et H O H Ga
CH2COPr-n H H Et H O H Gb
CH2CO2H H H Et H O H Ga
CH2CO2Me H H Et H O H Ga
CH2CO2Et H H Et H O H Ga
CH2CO2Pr-n H H Et H O H Gb
CH2OCH2CH＝CH2H H Et H O H Gb
CH2OCH2C≡CH H H Et H O H Gb
CH＝CHCO2Me H H Et H O H Ga
CH＝CHCO2Et H H Et H O H Ga
CH＝CHCO2Pr-n H H Et H O H Gb
CH＝CHCN H H Et H O H Ga
Ph H H Et H O H Ga
CH2Ph H H Et H O H Ga
OPh H H Et H O H Ga
SPh H H Et H O H Ga
SO2Ph H H Et H O H Ga
CONHMe H H Et H O H Ga
R4 R3 R2 R1 R5 X M Gn
CONHEt H H Et H O H Ga
CON(Me)2 H H Et H O H Ga
CON(Et)2 H H Et H O H Ga
CON(Pr-n)2 H H Et H O H Gb
F H H Cl H O H Gb
Cl H H Cl H O H Gb
Br H H Gl H O H Gb
I H H Cl H O H Gc
CH＝CH2 H H Cl H O H Gb
CH2CH＝CH2 H H Cl H O H Gb
C≡CH H H Cl H O H Gb
CH2C≡CH H H Cl H O H Gb
CH2F H H Cl H O H Gb
CHF2 H H Cl H O H Gb
CN H H Cl H O H Gb
NH2 H H Cl H O H Gb
NHCOMe H H Cl H O H Gb
CH2NH2 H H Cl H O H Gb
CH2NHCOMe H H Cl H O H Gb
CH2OCHF2 H H Cl H O H Gb
CF3 H H Gl H O H Gb
NO2 H H Cl H O H Gb
OMe H H Cl H O H Ga
OEt H H Cl H O H Ga
OPr-n H H Cl H O H Gb
SMe H H Cl H O H Ga
SEt H H Cl H O H Ga
SO2Me H H Cl H O H Ga
COMe H H Cl H O H Ga
COEt H H Cl H O H Ga
CO2H H H Cl H O H Ga
CO2Me H H Cl H O H Ga
CO2Et H H Cl H O H Ga
CO2Pr-n H H Cl H O H Gb
CO2Bu-n H H Cl H O H Gc
CH2Cl H H Cl H O H Ga
CH2Br H H Cl H O H Gb
CH2I H H Cl H O H Gb
CH2CF3 H H Cl H O H Gb
CH2CN H H Cl H O H Ga
R4 R3 R2 R1 R5 X M Gn
CH2OH H H Cl H O H Gb
CH2OMe H H Cl H O H Ga
CH2OEt H H Cl H O H Ga
CH2OPr-n H H Cl H O H Gb
CH2SMe H H Cl H O H Ga
CH2SEt H H Cl H O H Ga
CH2SO2Me H H Cl H O H Ga
CH2SO2Et H H Cl H O H Ga
CH2SPr-n H H Cl H O H Gb
CH2SPr-i H H Cl H O H Gb
CH2COMe H H Cl H O H Ga
CH2COEt H H Cl H O H Ga
CH2COPr-n H H Cl H O H Gb
CH2CO2H H H Cl H O H Ga
CH2CO2Me H H Cl H O H Ga
CH2CO2Et H H Cl H O H Ga
CH2CO2Pr-n H H Cl H O H Gb
CH2OCH2CH＝CH2 H H Cl H O H Gb
CH2OCH2C≡CH H H Cl H O H Gb
CH＝CHCO2Me H H Cl H O H Ga
CH＝CHCO2Et H H Cl H O H Ga
CH＝CHCO2Pr-n H H Cl H O H Gb
CH＝CHCN H H Cl H O H Ga
Ph H H Cl H O H Ga
CH2Ph H H Cl H O H Ga
OPh H H Cl H O H Ga
SPh H H Cl H O H Ga
SO2Ph H H Cl H O H Ga
CONHMe H H Cl H O H Ga
CONHEt H H Cl H O H Ga
CON(Me)2 H H Cl H O H Ga
CON(Et)2 H H Cl H O H Ga
CON(Pr-n)2 H H Cl H O H Gb
F H H CO2Me H O H Gb
Cl H H CO2Me H O H Gb
Br H H CO2Me H O H Gb
I H H CO2Me H O H Gc
CH＝CH2 H H CO2Me H O H Gb
CH2CH＝CH2 H H CO2Me H O H Gb
C≡CH H H CO2Me H O H Gb
R4 R3 R2 R1 R5 X M Gn
CH2C≡CH H H CO2Me H O H Gb
CH2F H H CO2Me H O H Gb
CHF2 H H CO2Me H O H Gb
CN H H CO2Me H O H Gb
NH2 H H CO2Me H O H Gb
NHCOMe H H CO2Me H O H Gb
CH2NH2 H H CO2Me H O H Gb
CH2NHCOMe H H CO2Me H O H Gb
CH2OCHF2 H H CO2Me H O H Gb
CF3 H H CO2Me H O H Gb
NO2 H H CO2Me H O H Gb
OMe H H CO2Me H O H Ga
OEt H H CO2Me H O H Ga
OPr-n H H CO2Me H O H Gb
SMe H H CO2Me H O H Ga
SEt H H CO2Me H O H Ga
SO2Me H H CO2Me H O H Ga
COMe H H CO2Me H O H Ga
COEt H H CO2Me H O H Ga
CO2H H H CO2Me H O H Ga
CO2Me H H CO2Me H O H Ga
CO2Et H H CO2Me H O H Ga
CO2Pr-n H H CO2Me H O H Gb
CO2Bu-n H H CO2Me H O H Gc
CH2Cl H H CO2Me H O H Ga
CH2Br H H CO2Me H O H Gb
CH2I H H CO2Me H O H Gb
CH2CF3 H H CO2Me H O H Gb
CH2CN H H CO2Me H O H Ga
CH2OH H H CO2Me H O H Gb
CH2OMe H H CO2Me H O H Ga
CH2OEt H H CO2Me H O H Ga
CH2OPr-n H H CO2Me H O H Gb
CH2SMe H H CO2Me H O H Ga
CH2SEt H H CO2Me H O H Ga
CH2SO2Me H H CO2Me H O H Ga
CH2SO2Et H H CO2Me H O H Ga
CH2SPr-n H H CO2Me H O H Gb
CH2SPr-i H H CO2Me H O H Gb
CH2COMe H H CO2Me H O H Ga
R4 R3 R2 R1 R5 X M Gn
CH2COEt H H CO2Me H O H Ga
CH2COPr-n H H CO2Me H O H Gb
CH2CO2H H H CO2Me H O H Ga
CH2CO2Me H H CO2Me H O H Ga
CH2CO2Et H H CO2Me H O H Ga
CH2CO2Pr-n H H CO2Me H O H Gb
CH2OCH2CH＝CH2 H H CO2Me H O H Gb
CH2OCH2C≡CH H H CO2Me H O H Gb
CH＝CHCO2Me H H CO2Me H O H Ga
CH＝CHCO2Et H H CO2Me H O H Ga
CH＝CHCO2Pr-n H H CO2Me H O H Gb
CH＝CHCN H H CO2Me H O H Ga
Ph H H CO2Me H O H Ga
CH2Ph H H CO2Me H O H Ga
OPh H H CO2Me H O H Ga
SPh H H CO2Me H O H Ga
SO2Ph H H CO2Me H O H Ga
CONHMe H H CO2Me H O H Ga
CONHEt H H CO2Me H O H Ga
CON(Me)2 H H CO2Me H O H Ga
CON(Et)2 H H CO2Me H O H Ga
CON(Pr-n)2 H H CO2Me H O H Gb
F H H CH2Cl H O H Gb
Cl H H CH2Cl H O H Gb
Br H H CH2Cl H O H Gb
I H H CH2Cl H O H Gc
CH＝CH2 H H CH2Cl H O H Gb
CH2CH＝CH2 H H CH2Cl H O H Gb
C≡CH H H CH2Cl H O H Gb
CH2C≡CH H H CH2Cl H O H Gb
CH2F H H CH2Cl H O H Gb
CHF2 H H CH2Cl H O H Gb
CN H H CH2Cl H O H Gb
NH2 H H CH2Cl H O H Gb
NHCOMe H H CH2Cl H O H Gb
CH2NH2 H H CH2Cl H O H Gb
CH2NHCOMe H H CH2Cl H O H Gb
CH2OCHF2 H H CH2Cl H O H Gb
CF3 H H CH2Cl H O H Gb
NO2 H H CH2Cl H O H Gb
R4 R3 R2 R1 R5 X M Gn
OMe H H CH2Cl H O H Ga
OEt H H CH2Cl H O H Ga
OPr-n H H CH2Cl H O H Gb
SMe H H CH2Cl H O H Ga
SEt H H CH2Cl H O H Ga
SO2Me H H CH2Cl H O H Ga
COMe H H CH2Cl H O H Ga
COEt H H CH2Cl H O H Ga
CO2H H H CH2Cl H O H Ga
CO2Me H H CH2Cl H O H Ga
CO2Et H H CH2Cl H O H Ga
CO2Pr-n H H CH2Cl H O H Gb
CO2Bu-n H H CH2Cl H O H Gc
CH2Cl H H CH2Cl H O H Ga
CH2Br H H CH2Cl H O H Gb
CH2I H H CH2Cl H O H Gb
CH2CF3 H H CH2Cl H O H Gb
CH2CN H H CH2Cl H O H Ga
CH2OH H H CH2Cl H O H Gb
CH2OMe H H CH2Cl H O H Ga
CH2OEt H H CH2Cl H O H Ga
CH2OPr-n H H CH2Cl H O H Gb
CH2SMe H H CH2Cl H O H Ga
CH2SEt H H CH2Cl H O H Ga
CH2SO2Me H H CH2Cl H O H Ga
CH2SO2Et H H CH2Cl H O H Ga
CH2SPr-n H H CH2Cl H O H Gb
CH2SPr-i H H CH2Cl H O H Gb
CH2COMe H H CH2Cl H O H Ga
CH2COEt H H CH2Cl H O H Ga
CH2COPr-n H H CH2Cl H O H Gb
CH2CO2H H H CH2Cl H O H Ga
CH2CO2Me H H CH2Cl H O H Ga
CH2CO2Et H H CH2Cl H O H Ga
CH2CO2Pr-n H H CH2Cl H O H Gb
CH2OCH2CH＝CH2 H H CH2Cl H O H Gb
CH2OCH2C≡CH H H CH2Cl H O H Gb
CH＝CHCO2Me H H CH2Cl H O H Ga
CH＝CHCO2Et H H CH2Cl H O H Ga
CH＝CHCO2Pr-n H H CH2Cl H O H Gb
R4 R3 R2 R1 R5 X M Gn
CH＝CHCN H H CH2Cl H O H Ga
Ph H H CH2Cl H O H Ga
CH2Ph H H CH2Cl H O H Ga
OPh H H CH2Cl H O H Ga
SPh H H CH2Cl H O H Ga
SO2Ph H H CH2Cl H O H Ga
CONHMe H H CH2Cl H O H Ga
CONHEt H H CH2Cl H O H Ga
CON(Me)2 H H CH2Cl H O H Ga
CON(Et)2 H H CH2Cl H O H Ga
CON(Pr-n)2 H H CH2Cl H O H Gb
F H H CH2OMe H O H Gb
Cl H H CH2OMe H O H Gb
Br H H CH2OMe H O H Gb
I H H CH2OMe H O H Gc
CH＝CH2 H H CH2OMe H O H Gb
CH2CH＝CH2 H H CH2OMe H O H Gb
C≡CH H H CH2OMe H O H Gb
CH2C≡CH H H CH2OMe H O H Gb
CH2F H H CH2OMe H O H Gb
CHF2 H H CH2OMe H O H Gb
CN H H CH2OMe H O H Gb
NH2 H H CH2OMe H O H Gb
NHCOMe H H CH2OMe H O H Gb
CH2NH2 H H CH2OMe H O H Gb
CH2NHCOMe H H CH2OMe H O H Gb
CH2OCHF2 H H CH2OMe H O H Gb
CF3 H H CH2OMe H O H Gb
NO2 H H CH2OMe H O H Gb
OMe H H CH2OMe H O H Ga
OEt H H CH2OMe H O H Ga
OPr-n H H CH2OMe H O H Gb
SMe H H CH2OMe H O H Ga
SEt H H CH2OMe H O H Ga
SO2Me H H CH2OMe H O H Ga
COMe H H CH2OMe H O H Ga
COEt H H CH2OMe H O H Ga
CO2H H H CH2OMe H O H Ga
CO2Me H H CH2OMe H O H Ga
CO2Et H H CH2OMe H O H Ga
R4 R3 R2 R1 R5 X M Gn
CO2Pr-n H H CH2OMe H O H Gb
CO2Bu-n H H CH2OMe H O H Gc
CH2Cl H H CH2OMe H O H Ga
CH2Br H H CH2OMe H O H Gb
CH2I H H CH2OMe H O H Gb
CH2CF3 H H CH2OMe H O H Gb
CH2CN H H CH2OMe H O H Ga
CH2OH H H CH2OMe H O H Gb
CH2OMe H H CH2OMe H O H Ga
CH2OEt H H CH2OMe H O H Ga
CH2OPr-n H H CH2OMe H O H Gb
CH2SMe H H CH2OMe H O H Ga
CH2SEt H H CH2OMe H O H Ga
CH2SO2Me H H CH2OMe H O H Ga
CH2SO2Et H H CH2OMe H O H Ga
CH2SPr-n H H CH2OMe H O H Gb
CH2SPr-i H H CH2OMe H O H Gb
CH2COMe H H CH2OMe H O H Ga
CH2COEt H H CH2OMe H O H Ga
CH2COPr-n H H CH2OMe H O H Gb
CH2CO2H H H CH2OMe H O H Ga
CH2CO2Me H H CH2OMe H O H Ga
CH2CO2Et H H CH2OMe H O H Ga
CH2CO2Pr-n H H CH2OMe H O H Gb
CH2OCH2CH＝CH2H H CH2OMe H O H Gb
CH2OCH2C≡CH H H CH2OMe H O H Gb
CH＝CHCO2Me H H CH2OMe H O H Ga
CH＝CHCO2Et H H CH2OMe H O H Ga
CH＝CHCO2Pr-n H H CH2OMe H O H Gb
CH＝CHCN H H CH2OMe H O H Ga
Ph H H CH2OMe H O H Ga
CH2Ph H H CH2OMe H O H Ga
OPh H H CH2OMe H O H Ga
SPh H H CH2OMe H O H Ga
SO2Ph H H CH2OMe H O H Ga
CONHMe H H CH2OMe H O H Ga
CONHEt H H CH2OMe H O H Ga
CON(Me)2 H H CH2OMe H O H Ga
CON(Et)2 H H CH2OMe H O H Ga
CON(Pr-n)2 H H CH2OMe H O H Gb
R4 R3 R2 R1 R5 X M Gn
F H H CH2SMe H O H Gb
Cl H H CH2SMe H O H Gb
Br H H CH2SMe H O H Gb
I H H CH2SMe H O H Gc
CH＝CH2 H H CH2SMe H O H Gb
CH2CH＝CH2 H H CH2SMe H O H Gb
C≡CH H H CH2SMe H O H Gb
CH2C≡CH H H CH2SMe H O H Gb
CH2F H H CH2SMe H O H Gb
CHF2 H H CH2SMe H O H Gb
CN H H CH2SMe H O H Gb
NH2 H H CH2SMe H O H Gb
NHCOMe H H CH2SMe H O H Gb
CH2NH2 H H CH2SMe H O H Gb
CH2NHCOMe H H CH2SMe H O H Gb
CH2OCHF2 H H CH2SMe H O H Gb
CF3 H H CH2SMe H O H Gb
NO2 H H CH2SMe H O H Gb
OMe H H CH2SMe H O H Ga
OEt H H CH2SMe H O H Ga
OPr-n H H CH2SMe H O H Gb
SMe H H CH2SMe H O H Ga
SEt H H CH2SMe H O H Ga
SO2Me H H CH2SMe H O H Ga
COMe H H CH2SMe H O H Ga
COEt H H CH2SMe H O H Ga
CO2H H H CH2SMe H O H Ga
CO2Me H H CH2SMe H O H Ga
CO2Et H H CH2SMe H O H Ga
CO2Pr-n H H CH2SMe H O H Gb
CO2Bu-n H H CH2SMe H O H Gc
CH2Cl H H CH2SMe H O H Ga
CH2Br H H CH2SMe H O H Gb
CH2I H H CH2SMe H O H Gb
CH2CF3 H H CH2SMe H O H Gb
CH2CN H H CH2SMe H O H Ga
CH2OH H H CH2SMe H O H Gb
CH2OMe H H CH2SMe H O H Ga
CH2OEt H H CH2SMe H O H Ga
CH2OPr-n H H CH2SMe H O H Gb
R4 R3 R2 R1 R5 X M Gn
CH2SMe H H CH2SMe H O H Ga
CH2SEt H H CH2SMe H O H Ga
CH2SO2Me H H CH2SMe H O H Ga
CH2SO2Et H H CH2SMe H O H Ga
CH2SPr-n H H CH2SMe H O H Gb
CH2SPr-i H H CH2SMe H O H Gb
CH2COMe H H CH2SMe H O H Ga
CH2COEt H H CH2SMe H O H Ga
CH2COPr-n H H CH2SMe H O H Gb
CH2CO2H H H CH2SMe H O H Ga
CH2CO2Me H H CH2SMe H O H Ga
CH2CO2Et H H CH2SMe H O H Ga
CH2CO2Pr-n H H CH2SMe H O H Gb
CH2OCH2CH＝CH2 H H CH2SMe H O H Gb
CH2OCH2C≡CH H H CH2SMe H O H Gb
CH＝CHCO2Me H H CH2SMe H O H Ga
CH＝CHCO2Et H H CH2SMe H O H Ga
CH＝CHCO2Pr-n H H CH2SMe H O H Gb
CH＝CHCN H H CH2SMe H O H Ga
Ph H H CH2SMe H O H Ga
CH2Ph H H CH2SMe H O H Ga
OPh H H CH2SMe H O H Ga
SPh H H CH2SMe H O H Ga
SO2Ph H H CH2SMe H O H Ga
CONHMe H H CH2SMe H O H Ga
CONHEt H H CH2SMe H O H Ga
CON(Me)2 H H CH2SMe H O H Ga
CON(Et)2 H H CH2SMe H O H Ga
CON(Pr-n)2 H H CH2SMe H O H Gb
F H H CN H O H Gb
Cl H H CN H O H Gb
Br H H CN H O H Gb
I H H CN H O H Gc
CH＝CH2 H H CN H O H Gb
CH2CH＝CH2 H H CN H O H Gb
C≡CH H H CN H O H Gb
CH2C≡CH H H CN H O H Gb
CH2F H H CN H O H Gb
CHF2 H H CN H O H Gb
CN H H CN H O H Gb
R4 R3 R2 R1 R5 X M Gn
NH2 H H CN H O H Gb
NHCOMe H H CN H O H Gb
CH2NH2 H H CN H O H Gb
CH2NHCOMe H H CN H O H Gb
CH2OCHF2 H H CN H O H Gb
CF3 H H CN H O H Gb
NO2 H H CN H O H Gb
OMe H H CN H O H Ga
OEt H H CN H O H Ga
OPr-n H H CN H O H Gb
SMe H H CN H O H Ga
SEt H H CN H O H Ga
SO2Me H H CN H O H Ga
COMe H H CN H O H Ga
COEt H H CN H O H Ga
CO2H H H CN H O H Ga
CO2Me H H CN H O H Ga
CO2Et H H CN H O H Ga
CO2Pr-n H H CN H O H Gb
CO2Bu-n H H CN H O H Gc
CH2Cl H H CN H O H Ga
CH2Br H H CN H O H Gb
CH2I H H CN H O H Gb
CH2CF3 H H CN H O H Gb
CH2CN H H CN H O H Ga
CH2OH H H CN H O H Gb
CH2OMe H H CN H O H Ga
CH2OEt H H CN H O H Ga
CH2OPr-n H H CN H O H Gb
CH2SMe H H CN H O H Ga
CH2SEt H H CN H O H Ga
CH2SO2Me H H CN H O H Ga
CH2SO2Et H H CN H O H Ga
CH2SPr-n H H CN H O H Gb
CH2SPr-i H H CN H O H Gb
CH2COMe H H CN H O H Ga
CH2COEt H H CN H O H Ga
CH2COPr-n H H CN H O H Gb
CH2CO2H H H CN H O H Ga
CH2CO2Me H H CN H O H Ga
R4 R3 R2 R1 R5 X M Gn
CH2CO2Et H H CN H O H Ga
CH2CO2Pr-n H H CN H O H Gb
CH2OCH2CH＝CH2 H H CN H O H Gb
CH2OCH2C≡CH H H CN H O H Gb
CH＝CHCO2Me H H CN H O H Ga
CH＝CHCO2Et H H CN H O H Ga
CH＝CHCO2Pr-n H H CN H O H Gb
CH＝CHCN H H CN H O H Ga
Ph H H CN H O H Ga
CH2Ph H H CN H O H Ga
OPh H H CN H O H Ga
SPh H H CN H O H Ga
SO2Ph H H CN H O H Ga
CONHMe H H CN H O H Ga
CONHEt H H CN H O H Ga
CON(Me)2 H H CN H O H Ga
CON(Et)2 H H CN H O H Ga
CON(Pr-n)2 H H CN H O H Gb
H H Cl Cl H O H Gb
H Cl H Cl H O H Gb
Cl H H Cl H O H Gb
H Cl Cl H H O H Gb
Cl H Cl H H O H Gb
Cl Cl H H H O H Gb
H H Cl Me H O H Gc
H Cl H Me H O H Gc
Me H Cl H H O H Gc
Me Cl H H H O H Gc
H H Cl Et H O H Gc
H Cl H Et H O H Gc
Et H Cl H H O H Gc
Et Cl H H H O H Gc
H H Br Br H O H Gb
H Br H Br H O H Gb
Br H H Br H O H Gb
H Br Br H H O H Gb
Br H Br H H O H Gb
Br Br H H H O H Gb表9
R1 R2 R3 X M Gn
H H H O H Ga
H H H S H G3
H H H O Me Gb
H H H O Et Gb
H H H O CH2CH＝CH2Gb
H H H O CH2C≡CH Gb
Me H H O H Ga
Me H H S H G3
H Me H O H Ga
H Me H S H G3
Et H H O H Ga
Et H H S H G3
H Et H O H Ga
H Et H S H G3
Pr-n H H O H Ga
Pr-n H H S H G3
H Pr-n H O H Gb
H Pr-n H S H G3
Pr-i H H O H Gb
H Pr-i H O H Gb
Bu-n H H O H Gb
H Bu-n H O H Gb
Me Me H O H Ga
Me Me H S H G3
Me Et H O H Ga
Me Et H S H G3
Me Pr-n H O H Gb
Me Pr-i H O H Gb
Et Me H O H Gb
R1 R2 R3 X M Gn
Et Me H S H G3
Et Et H O H Gb
Et Et H S H G3
Et Pr-n H O H Gb
Et Pr-i H O H Gb
Pr-n Me H O H Gb
Pr-n Et H O H Gb
Pr-n Pr-n H O H Gb
Pr-n Pr-i H O H Gb
Pr-i Me H O H Gb
Pr-i Et H O H Gb
Pr-i Pr-n H O H Gb
Pr-i Pr-i H O H Gb
H Me Me O H Ga
H Me Me S H G3
H Me Et O H Ga
H Me Et S H G3
H Me Pr-n O H Gb
H Me Pr-i O H Gb
H Et Et O H Gb
H Et Et S H G3
H Et Pr-n O H Gb
Me Me Me O H Ga
Me Me Me S H G3
Et Me Me O H Ga
Et Me Me S H G3
Pr-n Me Me O H Gb
Pr-i Me Me O H Gb
H Cl H O H Ga
H Cl H S H G3
H Br H O H Gb
H Br H S H G3
H I H O H Gb
H I H S H G3
H CF3 H O H Ga
H CF3 H S H G3
H NO2 H O H Ga
H NO2 H S H G3
H OMe H O H Ga
H OMe H S H G3
R1 R2 R3 X M Gn
H SMe H O H Ga
H SMe H S H G3
H SO2Me H O H Ga
H SO2Me H S H G3
H COMe H O H Ga
H COMe H S H G3
H CO2H H O H Ga
H CO2H H S H G3
H CO2Me H O H Ga
H CO2Me H S H G3
H CO2Et H O H Ga
H CO2Et H S H G3
H CH2Cl H O H Ga
H CH2Cl H S H G3
H CH2Br H O H Gb
H CH2Br H S H G3
H CH2I H O H Gb
H CH2I H S H G3
H CH2CF3 H O H Ga
H CH2CF3 H S H G3
H CH2CN H O H Ga
H CH2CN H S H G3
H CH2OH H O H Gb
H CH2OMe H O H Ga
H CH2OMe H S H G3
H CH2OEt H O H Ga
H CH2OEt H S H G3
H CH2SMe H O H Ga
H CH2SMe H S H G3
H CH2SEt H O H Ga
H CH2SEt H S H G3
H CH2COMe H O H Ga
H CH2COMe H S H G3
H CH2COEt H O H Ga
H CH2COEt H S H G3
H CH2CO2H H O H Ga
H CH2CO2H H S H G3
H CH2CO2Me H O H Ga
H CH2CO2Me H S H G3
H CH2CO2Et H O H Ga
R1 R2 R3 X M Gn
H CH2CO2Et H S H G3
H CH2OCH2CH＝CH2H O H Gb
H CH2OCH2CH＝CH2H S H G3
H CH2OCH2C≡CH H O H Gb
H CH2OCH2C≡CH H S H G3
H CH＝CHCO2Me H O H Ga
H CH＝CHCO2Me H S H G3
H CH＝CHCO2Et H O H Ga
H CH＝CHCO2Et H S H G3
H CH＝CHCN H O H Ga
H CH＝CHCN H S H G3
H Ph H O H Ga
H Ph H S H G3
H Ph-2-Cl H O H Ga
H Ph-2-Cl H S H G3
H Ph-3-Cl H O H Gb
H Ph-4-Cl H O H Gb
H CH2Ph H O H Ga
H CH2Ph H S H G3
H CH2Ph-2-Cl H O H Ga
H CH2Ph-2-Cl H S H G3
H CH2Ph-3-Cl H O H Gb
H CH2Ph-4-Cl H O H Gb
Me Cl H O H Ga
Me Cl H S H G3
Me Br H O H Gb
Me Br H S H G3
Me I H O H Gb
Me I H S H G3
Me CF3 H O H Ga
Me CF3 H S H G3
Me NO2 H O H Ga
Me NO2 H S H G3
Me OMe H O H Ga
Me OMe H S H G3
Me SMe H O H Ga
Me SMe H S H G3
Me SO2Me H O H Ga
Me SO2Me H S H G3
Me COMe H O H Ga
R1 R2 R3 X M Gn
Me COMe H S H G3
Me CO2H H O H Ga
Me CO2H H S H G3
Me CO2Me H O H Ga
Me CO2Me H S H G3
Me CO2Et H O H Ga
Me CO2Et H S H G3
Me CH2Cl H O H Ga
Me CH2Cl H S H G3
Me CH2Br H O H Gb
Me CH2Br H S H G3
Me CH2I H O H Gb
Me CH2I H S H G3
Me CH2CF3 H O H Ga
Me CH2CF3 H S H G3
Me CH2CN H O H Ga
Me CH2CN H S H G3
Me CH2OH H O H Gb
Me CH2OMe H O H Ga
Me CH2OMe H S H G3
Me CH2OEt H O H Ga
Me CH2OEt H S H G3
Me CH2SMe H O H Ga
Me CH2SMe H S H G3
Me CH2SEt H O H Ga
Me CH2SEt H S H G3
Me CH2COMe H O H Ga
Me CH2COMe H S H G3
Me CH2COEt H O H Ga
Me CH2COEt H S H G3
Me CH2CO2H H O H Ga
Me CH2CO2H H S H G3
Me CH2CO2Me H O H Ga
Me CH2CO2Me H S H G3
Me CH2CO2Et H O H Ga
Me CH2CO2Et H S H G3
Me CH2OCH2CH＝CH2 H O H Gb
Me CH2OCH2CH＝CH2 H S H G3
Me CH2OCH2C≡CH H O H Gb
Me CH2OCH2C≡CH H S H G3
R1 R2 R3 X M Gn
Me CH＝CHCO2Me H O H Ga
Me CH＝CHCO2Me H S H G3
Me CH＝CHCO2Et H O H Ga
Me CH＝CHCO2Et H S H G3
Me CH＝CHCN H O H Ga
Me CH＝CHCN H S H G3
Me Ph H O H Ga
Me Ph H S H G3
Me Ph-2-Cl H O H Ga
Me Ph-2-Cl H S H G3
Me Ph-3-Cl H O H Gb
Me Ph-4-Cl H O H Gb
Me CH2Ph H O H Ga
Me CH2Ph H S H G3
Me CH2Ph-2-Cl H O H Ga
Me CH2Ph-2-Cl H S H G3
Me CH2Ph-3-Cl H O H Gb
Me CH2Ph-4-Cl H O H Gb
Et Cl H O H Ga
Et Cl H S H G3
Et Br H O H Gb
Et Br H S H G3
Et I H O H Gb
Et I H S H G3
Et CF3 H O H Ga
Et CF3 H S H G3
Et NO2 H O H Ga
Et NO2 H S H G3
Et OMe H O H Ga
Et OMe H S H G3
Et SMe H O H Ga
Et SMe H S H G3
Et SO2Me H O H Ga
Et SO2Me H S H G3
Et COMe H O H Ga
Et COMe H S H G3
Et CO2H H O H Ga
Et CO2H H S H G3
Et CO2Me H O H Ga
Et CO2Me H S H G3
R1 R2 R3 X M Gn
Et CO2Et H O H Ga
Et CO2Et H S H G3
Et CH2Cl H O H Ga
Et CH2Cl H S H G3
Et CH2Br H O H Gb
Et CH2Br H S H G3
Et CH2I H O H Gb
Et CH2I H S H G3
Et CH2CF3 H O H Ga
Et CH2CF3 H S H G3
Et CH2CN H O H Ga
Et CH2CN H S H G3
Et CH2OH H O H Gb
Et CH2OMe H O H Ga
Et CH2OMe H S H G3
Et CH2OEt H O H Ga
Et CH2OEt H S H G3
Et CH2SMe H O H Ga
Et CH2SMe H S H G3
Et CH2SEt H O H Ga
Et CH2SEt H S H G3
Et CH2COMe H O H Ga
Et CH2COMe H S H G3
Et CH2COEt H O H Ga
Et CH2COEt H S H G3
Et CH2CO2H H O H Ga
Et CH2CO2H H S H G3
Et CH2CO2Me H O H Ga
Et CH2CO2Me H S H G3
Et CH2CO2Et H O H Ga
Et CH2CO2Et H S H G3
Et CH2OCH2CH＝CH2 H O H Gb
Et CH2OCH2CH＝CH2 H S H G3
Et CH2OCH2C≡CH H O H Gb
Et CH2OCH2C≡CH H S H G3
Et CH＝CHCO2Me H O H Ga
Et CH＝CHCO2Me H S H G3
Et CH＝CHCO2Et H O H Ga
Et CH＝CHCO2Et H S H G3
Et CH＝CHCN H O H Ga
R1 R2 R3 X M Gn
Et CH＝CHCN H S H G3
Et Ph H O H Ga
Et Ph H S H G3
Et Ph-2-Cl H O H Ga
Et Ph-2-Cl H S H G3
Et Ph-3-Cl H O H Gb
Et Ph-4-Cl H O H Gb
Et CH2Ph H O H Ga
Et CH2Ph H S H G3
Et CH2Ph-2-Cl H O H Ga
Et CH2Ph-2-Cl H S H G3
Et CH2Ph-3-Cl H O H Gb
Et CH2Ph-4-Cl H O H Gb
Cl Me H O H Ga
Cl Me H S H G3
Br Me H O H Gb
Br Me H S H G3
I Me H O H Gb
I Me H S H G3
CF3 Me H O H Ga
CF3 Me H S H G3
NO2 Me H O H Ga
NO2 Me H S H G3
OMe Me H O H Ga
OMe Me H S H G3
SMe Me H O H Ga
SMe Me H S H G3
SO2Me Me H O H Ga
SO2Me Me H S H G3
COMe Me H O H Ga
COMe Me H S H G3
CO2H Me H O H Ga
CO2H Me H S H G3
CO2Me Me H O H Ga
CO2Me Me H S H G3
CO2Et Me H O H Ga
CO2Et Me H S H G3
CH2Cl Me H O H Ga
CH2Cl Me H S H G3
CH2Br Me H O H Gb
R1 R2 R3 X M Gn
CH2Br Me H S H G3
CH2I Me H O H Gb
CH2I Me H S H G3
CH2CF3 Me H O H Ga
CH2CF3 Me H S H G3
CH2CN Me H O H Ga
CH2CN Me H S H G3
CH2OH Me H O H Gb
CH2OMe Me H O H Ga
CH2OMe Me H S H G3
CH2OEt Me H O H Ga
CH2OEt Me H S H G3
CH2SMe Me H O H Ga
CH2SMe Me H S H G3
CH2SEt Me H O H Ga
CH2SEt Me H S H G3
CH2COMe Me H O H Ga
CH2COMe Me H S H G3
CH2COEt Me H O H Ga
CH2COEt Me H S H G3
CH2CO2H Me H O H Ga
CH2CO2H Me H S H G3
CH2CO2Me Me H O H Ga
CH2CO2Me Me H S H G3
CH2CO2Et Me H O H Ga
CH2CO2Et Me H S H G3
CH2OCH2CH＝CH2 Me H O H Gb
CH2OCH2CH＝CH2 Me H S H G3
CH2OCH2C≡CH Me H O H Gb
CH2OCH2C≡CH Me H S H G3
CH＝CHCO2Me Me H O H Ga
CH＝CHCO2Me Me H S H G3
CH＝CHCO2Et Me H O H Ga
CH＝CHCO2Et Me H S H G3
CH＝CHCN Me H O H Ga
CH＝CHCN Me H S H G3
Ph Me H O H Ga
Ph Me H S H G3
Ph-2-Cl Me H O H Ga
Ph-2-Cl Me H S H G3
R1 R2 R3 X M Gn
Ph-3-Cl Me H O H Gb
Ph-4-Cl Me H O H Gb
CH2Ph Me H O H Ga
CH2Ph Me H S H G3
CH2Ph-2-Cl Me H O H Ga
CH2Ph-2-Cl Me H S H G3
CH2Ph-3-Cl Me H O H Gb
CH2Ph-4-Cl Me H O H Gb
Cl Et H O H Ga
Cl Et H S H G3
Br Et H O H Gb
Br Et H S H G3
I Et H O H Gb
I Et H S H G3
CF3 Et H O H Ga
CF3 Et H S H G3
NO2 Et H O H Ga
NO2 Et H S H G3
OMe Et H O H Ga
OMe Et H S H G3
SMe Et H O H Ga
SMe Et H S H G3
SO2Me Et H O H Ga
SO2Me Et H S H G3
COMe Et H O H Ga
COMe Et H S H G3
CO2H Et H O H Ga
CO2H Et H S H G3
CO2Me Et H O H Ga
CO2Me Et H S H G3
CO2Et Et H O H Ga
CO2Et Et H S H G3
CH2Cl Et H O H Ga
CH2Cl Et H S H G3
CH2Br Et H O H Gb
CH2Br Et H S H G3
CH2I Et H O H Gb
CH2I Et H S H G3
CH2CF3 Et H O H Ga
CH2CF3 Et H S H G3
R1 R2 R3 X M Gn
CH2CN Et H O H Ga
CH2CN Et H S H G3
CH2OH Et H O H Gb
CH2OMe Et H O H Ga
CH2OMe Et H S H G3
CH2OEt Et H O H Ga
CH2OEt Et H S H G3
CH2SMe Et H O H Ga
CH2SMe Et H S H G3
CH2SEt Et H O H Ga
CH2SEt Et H S H G3
CH2COMe Et H O H Ga
CH2COMe Et H S H G3
CH2COEt Et H O H Ga
CH2COEt Et H S H G3
CH2CO2H Et H O H Ga
CH2CO2H Et H S H G3
CH2CO2Me Et H O H Ga
CH2CO2Me Et H S H G3
CH2CO2Et Et H O H Ga
CH2CO2Et Et H S H G3
CH2OCH2CH＝CH2 Et H O H Gb
CH2OCH2CH＝CH2 Et H S H G3
CH2OCH2C≡CH Et H O H Gb
CH2OCH2C≡CH Et H S H G3
CH＝CHCO2Me Et H O H Ga
CH＝CHCO2Me Et H S H G3
CH＝CHCO2Et Et H O H Ga
CH＝CHCO2Et Et H S H G3
CH＝CHCN Et H O H Ga
CH＝CHCN Et H S H G3
Ph Et H O H Ga
Ph Et H S H G3
Ph-2-Cl Et H O H Ga
Ph-2-Cl Et H S H G3
Ph-3-Cl Et H O H Gb
Ph-4-Cl Et H O H Gb
CH2Ph Et H O H Ga
CH2Ph Et H S H G3
CH2Ph-2-Cl Et H O H Ga
R1 R2 R3 X M Gn
CH2Ph-2-Cl Et H S H G3
CH2Ph-3-Cl Et H O H Gb
CH2Ph-4-Cl Et H O H Gb表10
R1 R2 R3 X M Gn
H H H O H Ga
H H H S H G3
H H H O Me Gb
H H H O Et Gb
H H H O CH2CH＝CH2Gb
H H H O CH2C≡CH Gb
Me H H O H Ga
Me H H S H G3
H Me H O H Ga
H Me H S H G3
Et H H O H Gb
Et H H S H G3
H Et H O H Ga
H Et H S H G3
Pr-n H H O H Gb
H Pr-n H O H Gb
H Pr-n H S H G3
Me Me H O H Ga
Me Me H S H G3
Me Et H O H Gb
R1 R2 R3 X M Gn
Me Pr-n H O H Gb
Me Pr-i H O H Gb
Et Me H O H Gb
Et Et H O H Gb
Et Pr-n H O H Gb
Et Pr-i H O H Gb
Pr-n Me H O H Gb
Pr-n Et H O H Gb
Pr-n Pr-n H O H Gb
Pr-n Pr-i H O H Gb
Pr-i Me H O H Gb
Pr-i Et H O H Gb
Pr-i Pr-n H O H Gb
Pr-i Pr-i H O H Gb
H Me Me O H Ga
H Me Me S H G3
H Me Et O H Ga
H Me Et S H G3
H Me Pr-n O H Gb
H Me Pr-i O H Gb
H Me Pr-i S H G3
H Et Et O H Gb
H Et Pr-n O H Gb
Me Me Me O H Ga
Me Me Me S H G3
Et Me Me O H Gb
Pr-n Me Me O H Gb
Pr-i Me Me O H Gb
H Ph H O H Ga
H Ph H S H G3
H CH2Ph H O H Ga
H CH2Ph H S H G3
Me Ph H O H Ga
Me Ph H S H G3
Me CH2Ph H O H Ga
Me CH2Ph H S H G3
Et Ph H O H Ga
R1 R2 R3 X M Gn
Et Ph H S H G3
Et CH2Ph H O H Ga
Et CH2Ph H S H G3
Ph Me H O H Ga
Ph Me H S H G3
CH2Ph Me H O H Ga
CH2Ph Me H S H G3
Ph Et H O H Ga
Ph Et H S H G3
CH2Ph Et H O H Ga
CH2Ph Et H S H G3
当本发明的化合物用作除草剂时，通常与合适的载体混合在一起，例如(1)固态载体，如粘土、滑石、膨润土或硅藻土，或(2)液态载体，如水、醇(如甲醇或乙醇)、芳族烃(如苯、甲苯或二甲苯)、卤化烃、醚、酮、酯(如乙酸乙酯)或酰胺(如二甲基甲酰胺)。根据需要，可以加入乳化剂、分散剂、悬浮剂、渗透剂、铺展剂或稳定剂，以制备任选的配方，如液剂、可乳化的浓缩液、可湿性粉末、粉剂、粒剂或可流动剂。
以下将给出以本发明之化合物作为活性组分的除草剂的配方例。然而，应当明白，本发明决非限于这些具体的例子(在以下配方例中，“份数”系指“以重量计的份数”)。配方例1：可湿性粉末本发明之1号化合物 20份Zeeklite A(系高岭土型粘土的商品名称，Zeeklite工业有限公司出品) 76份Sorpol 5039(系非离子型表面活性剂和阴离子型表面活性剂的混合物的商品名称，Toho化学有限公司出品) 2份Carplex(由表面活性剂和细硅石粉的混合物所组成的防凝聚剂的商晶名称，Shiohogi医药有限公司出品) 2份
上述组分经均匀磨细和混和后，形成可湿性粉末。配方例2可湿性粉末(Wettable Ppwer)本发明之14号化合物 40份Zeeklite A(系高岭土型粘土的商品名称，Zeeklite工业有限公司出品) 54份Sorpol 5039(非离子型表面活性剂和阴离子型表面活性剂的混合物之商品名称，Toho化学有限公司出品) 2份Carplex(由表面活性剂和细硅石粉的混合物所组成的防凝聚剂的商品名称，Shionogi医药有限公司出品) 4份
将上述组分均匀地磨细和混合，以形成可湿性粉末。配方例3可乳化的浓缩液本发明之2号化合物 5份二甲苯 75份N，N-二甲基甲酰胺 15份Sorpol 2680(非离子型表面活剂和阴离子型表面活性剂所组成的混合物的商品名称，Toho化学有限公司出品) 5份
将上述组份均匀地混合，以得到可乳化的浓缩液。使用时，将上述可乳化的浓缩液稀释至10至10,000倍，每公顷田活性组分的施用剂量为0.005至10公斤。配方例4可流动剂(flowable)。本发明之7号化合物 25份Agrizole S-710(非离子型表而活性剂的商品名称，Kao公司出品) 10份Runox 1000 C(阴离子型表面活性剂的商品名称，Toho化学有限公司出品) 0.5份1％ Rodopol水(增稠剂的商品名称，Rhone-Poulenc出品) 20份水 44.5份
将上述组分均匀地混合，以形成可流动剂。配方例5可流动剂本发明之6号化合物 40份Agrizole S-710(非离子型表面活性剂的商品名称，Kao公司出品) 10份Runox 1000 C(阴离子型表面活性剂的商品名称，Toho化学有限公司出品) 0.5份1％ Rodopol水(增稠剂的商品名称，Rhone-Poulenc出品) 20份水 29.5份
将上述组分均匀地混合，以形成可流动剂。配方例6粒剂本发明之22号化合物 1份膨润土 55份滑石 44份
将上述组分均匀地磨细和混合，然后添加少量水，将混合物捏和和搅拌，经成粒机制成颗粒后，进行干燥，由此得到粒剂。
另外，根据需要，在进行配方或施用除草剂时，可结合各种杀虫剂、杀菌剂、植物生长调节剂或增效剂一起使用。
若将其他除草剂与本发明的除草剂结合使用时，此处可提一下的是诸如在“Farm Chemical Handbook第73版(1987)”中所揭示的化合物。
本发明的化合物不仅适用于农田和园艺田，如旱地、水稻田和果园，而且也适用于对非农田，如运动场、空间地和铁路边的各种杂草的控制。它们的施用剂量随着施用地点、施用季节、杂草种类、作物种类等而改变。然而，每公顷的剂量一般在0.005至10公斤的范围内。
以下将结合具体的试验例对本发明化合物的除草活性性进行描述。。用于下述试验例中的化合物编号与上述化合物的编号相一致。试验例1 对土壤处理的除草效能的试验
在一只长15厘米，宽22厘米，深6厘米的塑料盒中充填灭菌的洪积土，然后播种稗( )，犬马唐()一年生莎草( )，茄属()，毛状牛膝菊属( )，印度蔊菜( )稻谷( )，玉米( )，小麦( )，大豆( )和棉花( )的种于。在上面再覆盖一层厚约1.5厘米的土层，并将除草剂溶液均匀地施加到土壤表面，以使活性组分从预定的浓度分布。用水稀释上述配方例中所述的可湿性粉末以制备除草剂溶液，并用一只小型喷雾器将其施加到全部土壤表面。除草剂溶液施用后四周，根据下述标准等级来确定对各种杂草的除草效果。所得结果示于表11(化合物的编号与上述实施例中的一致)。、
本发明一些化合物对某些作物具有选择性。
标准等级
5：生长控制率大于90％(几乎完全枯萎)；
4：生长控制率为70％至90％；
3：生长控制率为40％至70％：
2：生长控制率为20％至40％；
1：生长控制率为5％至20％；
0：长度控制率小于5％(几乎无效果)。
上述生长控制率由下式计算：
在一只长15厘米，宽22厘米，深6厘米的塑料盒中充填灭菌的洪积土，并点播( )稗、大马唐、一年生莎草、茄属、毛状牛膝菊属、印度 草、稻谷、玉米、小麦、大豆、棉花和甜菜( )的种子。然后在其上面覆盖一层厚约1.5厘米的土层。当各种杂草作物生长至2至3片叶子阶段时，在叶子上均匀地喷洒除草剂溶液，以使活性组分以预定的浓度施加。
用水稀释上述配方例所述的可湿性粉末，以制备除草剂溶液，并用一只小型喷雾器将其施加到杂草和作物的叶了的全部表面上。施用除草剂溶液后四周，根据试验例1中所述的标准等级来确定对每一种杂草的除草效能，结果示于表12(表中化合物的编号与前面实施例中的一致)。
在表11和12中使用下述缩略词：
剂量：活性组分的剂量(克/亩)：
EC：Echinochloa crus-galli(稗)
Dl：Digitaria adscendens (大马唐)
CY：Cyperus microiria (一年生莎草)
SO：Solanum nigrum (茄属)
GA：Galinsoga ciliate (毛状牛膝菊属)
RO：Rorippa indca (印度蔊菜)
OY：Oryza sativa (稻)
ZE：Zea mays (玉米)
TR：Triticum vulgare (小麦)
GY：Glycine max (大豆)
CO：Gossypium spp. (棉花)
BE：Beta vulgaris (甜菜)表11化合物编号剂量 EC DI CY SO GA RO OY ZE TR GY GO
1.6 5 5 5 5 5 5 5 5 0 5 0
1 3.2 5 5 5 5 5 5 5 5 1 5 1
6.3 5 5 5 5 5 5 5 5 2 5 2
1.6 3 5 5 4 5 5 5 5 2 5 0
3 3.2 4 5 5 5 5 5 5 5 3 5 1
6.3 5 5 5 5 5 5 5 5 4 5 2
1.6 4 5 5 5 5 5 5 5 0 5 0
4 3.2 5 5 5 5 5 5 5 5 1 5 1
6.3 5 5 5 5 5 5 5 5 2 5 2
1.6 4 5 5 5 5 5 5 4 0 4 0
5 3.2 5 5 5 5 5 5 5 5 1 5 0
6.3 5 5 5 5 5 5 5 5 2 5 0
6 6.3 3 5 4 4 4 5 5 5 0 4 0
7 6.3 5 5 5 5 5 5 5 5 3 5 5表11(续)化合物编号剂量 EC DI CY SO GA RO OY ZE TR GY GO
8 6.3 3 4 5 3 5 5 5 5 1 5 1
9 6.3 5 4 5 5 5 5 5 5 2 5 5
10 6.3 4 4 5 5 5 5 5 5 3 5 0
12 6.3 3 4 5 3 5 5 5 4 3 4 0
1.6 5 5 5 4 5 5 5 5 5 5 0
14 3.2 5 5 5 5 5 5 5 5 5 5 1
6.3 5 5 5 5 5 5 5 5 5 5 2
1.6 4 4 5 3 5 5 5 5 5 4 0
15 3.2 5 5 5 4 5 5 5 5 5 5 0
6.3 5 5 5 5 5 5 5 5 5 5 1
1.6 5 5 5 5 5 5 5 5 5 5 0
16 3.2 5 5 5 5 5 5 5 5 5 5 0
6.3 5 5 5 5 5 5 5 5 5 5 1
1.6 3 4 5 4 5 5 5 1 2 5 1
17 3.2 4 5 5 5 5 5 5 2 3 5 2
6.3 5 5 5 5 5 5 5 3 4 5 3表11(续)化合物编号剂量 EC DI CY SO GA RO OY ZE TR GY GO
20 6.3 5 5 5 5 5 5 5 1 1 1 0
1.6 5 5 5 3 5 5 5 5 5 5 5
21 3.2 5 5 5 4 5 5 5 5 5 5 5
6.3 5 5 5 5 5 5 5 5 5 5 5
1.6 5 5 5 2 5 5 5 4 2 0 0
22 3.2 5 5 5 3 5 5 5 5 3 1 0
6.3 5 5 5 4 5 5 5 5 4 3 1
23 6.3 4 3 5 4 5 5 5 2 1 3 2
24 6.3 4 4 5 2 5 5 5 2 4 2 2
27 6.3 3 2 5 3 5 5 3 4 0 4 3
30 6.3 3 2 4 4 5 5 5 5 2 4 3
35 6.3 5 5 5 4 4 5 5 2 0 4 0
37 6.3 2 3 4 3 4 4 5 3 0 4 2
0.4 5 5 5 5 5 5 5 5 1 5 1
38 0.8 5 5 5 5 5 5 5 5 2 5 2
1.6 5 5 5 5 5 5 5 5 3 5 3表11(续)
EC DI CY SO GA RO OY ZE TR GY GO化合物编号剂量
0.4 2 3 5 2 5 5 5 2 0 3 0
39 0.8 4 4 5 3 5 5 5 3 0 4 1
1.6 5 5 5 4 5 5 5 4 1 5 2
40 1.6 3 5 5 5 5 5 5 2 0 3 0
41 1.6 3 3 4 5 5 5 5 2 0 0 0
42 6.3 1 1 4 3 5 5 4 0 0 0 0
0.4 5 5 5 5 5 5 5 5 5 5 5
43 0.8 5 5 5 5 5 5 5 5 5 5 5
1.6 5 5 5 5 5 5 5 5 5 5 5
0.4 2 5 5 3 5 5 5 3 4 3 0
44 0.8 3 5 5 4 5 5 5 4 5 4 1
1.6 4 5 5 5 5 5 5 5 5 5 3
0.4 2 5 5 4 5 5 5 4 5 4 3
45 0.8 4 5 5 5 5 5 5 5 5 5 4
1.6 5 5 5 5 5 5 5 5 5 5 5表11(续)
EC DI CY SO GA RO OY ZE TR GY GO化合物编号剂量
0.4 3 5 4 4 5 5 5 3 1 2 3
46 0.8 4 5 5 5 5 5 5 4 2 3 4
1.6 5 5 5 5 5 5 5 5 3 4 5
1.6 2 2 5 3 5 5 5 2 1 2 0
47 3.2 3 3 5 4 5 5 5 3 2 3 1
6.3 5 5 5 5 5 5 5 4 4 4 2
1.6 4 5 5 3 5 5 5 1 0 2 1
49 3.2 5 5 5 4 5 5 5 2 1 3 2
6.3 5 5 5 5 5 5 5 3 2 4 3
50 6.3 3 5 5 4 5 5 5 3 0 3 2
51 6.3 2 4 5 3 5 5 4 2 0 2 1
1.6 2 1 5 2 5 5 4 1 2 3 1
52 3.2 2 2 5 4 5 5 5 2 3 4 2
6.3 3 3 5 5 5 5 5 3 4 5 3表11(续)
EC DI CY SO GA RO OY ZE TR GY GO化合物编号剂量
53 1.6 3 4 4 4 5 5 5 2 3 4 3
54 6.3 4 3 3 3 4 5 5 4 4 2 1
0.4 5 5 5 2 5 5 5 3 0 4 0
56 0.8 5 5 5 3 5 5 5 4 1 5 0
1.6 5 5 5 4 5 5 5 5 3 5 1
1.6 3 4 4 2 5 5 4 3 0 3 0
57 3.2 4 5 5 3 5 5 5 4 1 4 1
6.3 5 5 5 4 5 5 5 5 3 5 2
59 6.3 3 2 5 5 5 5 5 3 0 0 2
61 6.3 3 2 5 5 5 5 5 3 0 0 2
62 6.3 5 5 5 5 5 5 5 4 2 5 5
64 6.3 2 5 5 5 5 5 0 0 0 2 0
1.6 3 4 4 2 3 3 4 3 0 0 0
65 3.2 4 5 5 3 4 4 5 4 1 0 0
6.3 5 5 5 4 5 5 5 4 2 1 1表11(续)
EC DI CY SO GA RO OY ZE TR GY GO化合物编号剂量
1.6 3 4 3 2 5 5 5 0 1 1 0
67 3.2 4 5 4 3 5 5 5 1 2 2 0
6.3 5 5 5 4 5 5 5 2 3 3 0
1.6 5 5 5 3 4 5 5 2 0 1 1
72 3.2 5 5 5 4 5 5 5 4 1 2 2
6.3 5 5 5 5 5 5 5 5 2 4 3
1.6 4 5 5 4 5 5 5 4 4 2 2
73 3.2 5 5 5 5 5 5 5 5 5 3 3
6.3 5 5 5 5 5 5 5 5 5 4 4
0.8 2 4 4 2 5 5 5 3 4 3 0
74 1.6 4 5 5 4 5 5 5 4 5 4 1
3.2 5 5 5 5 5 5 5 5 5 5 2
1.6 2 4 4 2 5 5 1 0 0 1 2
75 3.2 3 5 5 3 5 5 2 1 0 2 3
6.3 4 5 5 4 5 5 3 2 2 3 4表11(续)
EC DI CY SO GA RO OY ZE TR GY GO化合物编号剂量
0.4 5 5 5 5 5 5 5 5 5 4 3
77 0.8 5 5 5 5 5 5 5 5 5 5 4
1.6 5 5 5 5 5 5 5 5 5 5 5
0.4 4 5 5 3 5 5 5 4 5 3 2
78 0.8 5 5 5 4 5 5 5 5 5 4 3
1.6 5 5 5 5 5 5 5 5 5 5 4
0.4 3 5 5 5 5 5 5 1 2 1 1
79 0.8 4 5 5 5 5 5 5 2 4 2 1
1.6 5 5 5 5 5 5 5 4 5 4 2表12
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
1.6 5 5 5 5 5 5 5 5 0 5 5 5
1 3.2 5 5 5 5 5 5 5 5 1 5 5 5
6.3 5 5 5 5 5 5 5 5 2 5 5 5
2 6.3 3 2 5 5 5 5 2 1 0 4 2 5
1.6 5 4 5 5 5 5 5 5 1 5 3 5
3 3.2 5 5 5 5 5 5 5 5 2 5 4 5
6.3 5 5 5 5 5 5 5 5 3 5 5 5
1.6 5 4 5 5 5 5 5 4 0 5 5 5
4 3.2 5 5 5 5 5 5 5 5 0 5 5 5
6.3 5 5 5 5 5 5 5 5 1 5 5 5
1.6 5 4 4 5 5 5 5 3 0 4 2 5
5 3.2 5 5 5 5 5 5 5 4 0 5 3 5
6.3 5 5 5 5 5 5 5 5 1 5 4 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
6 6.3 5 4 5 5 5 5 5 4 0 4 1 5
7 6.3 5 4 5 5 5 5 5 5 2 5 5 5
8 6.3 4 3 5 4 5 5 5 5 1 5 4 5
9 6.3 5 4 5 5 5 5 5 5 1 5 5 5
10 6.3 5 4 5 5 5 5 5 5 2 5 2 5
12 6.3 5 3 3 5 5 5 5 3 3 4 1 5
13 6.3 3 2 3 5 5 5 4 3 3 3 1 5
1.6 5 3 5 5 5 5 5 5 5 5 1 5
14 3.2 5 4 5 5 5 5 5 5 5 5 2 5
6.3 5 5 5 5 5 5 5 5 5 5 3 5
1.6 5 2 4 3 5 5 2 3 2 5 0 5
15 3.2 5 3 5 4 5 5 3 4 3 5 1 5
6.3 5 4 5 5 5 5 4 5 4 5 2 5
1.6 5 3 3 5 5 5 4 3 2 5 1 5
16 3.2 5 4 4 5 5 5 5 4 3 5 2 5
6.3 5 5 5 5 5 5 5 5 4 5 3 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
1.6 5 2 2 3 4 4 5 1 2 5 1 4
17 3.2 5 3 3 4 5 5 5 2 3 5 2 5
6.3 5 4 4 5 5 5 5 3 4 5 3 5
20 6.3 5 2 3 5 5 5 2 3 1 5 1 4
1.6 5 2 3 3 5 5 5 4 5 5 1 5
21 3.2 5 3 4 4 5 5 5 5 5 5 2 5
6.3 5 4 5 5 5 5 5 5 5 5 3 5
1.6 5 1 3 3 3 5 2 4 2 4 0 5
22 3.2 5 2 4 4 4 5 3 5 3 5 0 5
6.3 5 3 5 5 5 5 4 5 4 5 1 5
23 6.3 4 3 3 4 5 5 3 4 1 4 1 5
24 6.3 4 3 3 3 4 5 3 3 1 4 2 5
27 6.3 4 2 4 5 5 5 5 3 0 5 2 5
28 6.3 3 2 4 4 5 5 2 1 0 5 2 5
30 6.3 5 3 5 5 5 5 5 5 3 5 5 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
31 6.3 4 3 5 4 5 5 5 3 2 5 5 5
35 6.3 4 3 3 4 5 5 5 5 2 5 2 5
37 6.3 4 3 3 5 5 5 5 5 0 5 5 5
0.4 5 5 5 5 5 5 5 4 0 5 5 5
38 0.8 5 5 5 5 5 5 5 5 1 5 5 5
1.6 5 5 5 5 5 5 5 5 2 5 5 5
0.4 4 3 5 5 5 5 4 4 0 5 4 5
39 0.8 5 4 5 5 5 5 5 5 1 5 5 5
1.6 5 5 5 5 5 5 5 5 2 5 5 5
40 1.6 5 5 5 5 5 5 4 3 1 4 3 5
41 1.6 4 3 3 5 5 5 4 2 0 3 3 5
42 6.3 1 1 3 5 5 5 3 0 0 4 2 5
0.4 5 4 5 5 5 5 5 5 5 5 5 4
43 0.8 5 5 5 5 5 5 5 5 5 5 5 5
1.6 5 5 5 5 5 5 5 5 5 5 5 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
0.4 3 2 2 5 5 5 5 3 4 5 4 3
44 0.8 4 2 4 5 5 5 5 4 5 5 5 4
1.6 5 3 5 5 5 5 5 5 5 5 5 5
0.4 3 4 4 5 5 5 4 4 4 4 4 3
45 0.8 4 5 5 5 5 5 5 5 5 5 5 4
1.6 5 5 5 5 5 5 5 5 5 5 5 5
0.4 4 3 4 5 5 5 3 4 2 3 4 3
46 0.8 5 4 5 5 5 5 4 5 3 4 5 4
1.6 5 5 5 5 5 5 5 5 4 5 5 5
1.6 2 0 5 3 5 5 4 3 0 3 3 5
47 3.2 3 1 5 4 5 5 5 4 0 4 4 5
6.3 4 2 5 5 5 5 5 5 1 5 5 5
1.6 4 2 5 5 5 5 4 4 0 5 3 5
49 3.2 5 3 5 5 5 5 5 5 1 5 4 5
6.3 5 4 5 5 5 5 5 5 2 5 5 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
50 6.3 3 2 5 5 5 5 5 3 2 5 4 5
51 6.3 3 2 5 4 4 5 4 4 0 5 3 5
1.6 1 1 5 4 5 5 3 3 0 4 4 5
52 3.2 2 2 5 5 5 5 4 4 1 5 5 5
6.3 3 3 5 5 5 5 5 5 2 5 5 5
53 1.6 3 2 5 5 5 5 4 4 2 5 4 5
54 6.3 4 3 4 5 5 5 5 4 4 5 4 5
0.4 4 3 5 3 5 5 4 4 0 5 4 5
56 0.8 5 4 5 4 5 5 5 5 0 5 5 5
1.6 5 5 5 5 5 5 5 5 1 5 5 5
1.6 4 3 4 5 5 5 3 3 1 5 4 5
57 3.2 5 4 5 5 5 5 4 4 2 5 5 5
6.3 5 5 5 5 5 5 5 5 3 5 5 5
59 6.3 3 2 5 5 5 5 4 3 0 1 4 5
61 6.3 3 2 5 5 5 5 4 3 0 1 4 2表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
62 6.3 5 4 5 5 5 5 5 4 2 5 5 5
64 6.3 3 3 4 5 5 5 0 1 1 3 4 4
1.6 2 2 5 3 5 3 4 2 2 0 3 3
65 3.2 3 3 5 4 5 4 5 3 3 1 4 4
6.3 4 4 5 5 5 5 5 4 4 2 5 4
1.6 2 2 5 2 4 4 3 3 0 0 3 2
67 3.2 3 3 5 3 5 5 4 4 1 1 4 3
6.3 4 4 5 4 5 5 4 4 2 2 4 4
1.6 1 1 5 5 5 5 5 0 0 2 2 3
68 3.2 2 2 5 5 5 5 5 1 0 3 3 4
6.3 3 3 5 5 5 5 5 2 0 4 4 5
71 6.3 5 3 5 5 5 5 5 4 4 5 2 4
1.6 3 1 3 5 5 4 5 2 0 5 3 5
72 3.2 4 2 4 5 5 5 5 3 1 5 4 5
6.3 5 3 5 5 5 5 5 4 2 5 5 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
1.6 5 2 5 5 5 5 5 4 3 4 5 5
73 3.2 5 3 5 5 5 5 5 5 4 5 5 5
6.3 5 4 5 5 5 5 5 5 5 5 5 5
0.8 3 2 3 3 5 5 4 4 4 5 2 3
74 1.6 4 3 4 4 5 5 5 5 5 5 3 4
3.2 5 4 5 5 5 5 5 5 5 5 4 5
1.6 3 2 4 4 5 3 5 4 4 5 2 4
75 3.2 4 3 5 5 5 4 5 5 5 5 2 5
6.3 5 4 5 5 5 5 5 5 5 5 3 5
0.4 4 3 4 5 5 5 5 5 5 5 5 5
77 0.8 5 4 5 5 5 5 5 5 5 5 5 5
1.6 5 5 5 5 5 5 5 5 5 5 5 5表12(续)
EC DI CY SO GA RO OY ZE TR GY GO BE化合物编号剂量
0.4 3 3 4 4 5 5 5 5 4 5 3 4
78 0.8 4 4 5 5 5 5 5 5 5 5 4 5
1.6 5 5 5 5 5 5 5 5 5 5 5 5
0.4 2 2 3 5 4 3 3 3 3 4 3 4
79 0.8 3 3 4 5 5 5 4 4 4 5 4 5
1.6 4 4 5 5 5 5 5 5 5 5 5 5
Claims (4)
1.一种具有分子式(I)
的磺内酰胺磺胺衍生物或其农业上有用的盐类，上式中Q为
或
其中R1，R2，R3，R4和R5各自为氢、C1-C6的烷基、C2-C6的烯基、C2-C6的炔基、卤素、三氟甲基、硝基、氰基、氨基、C1-C6的烷氧基、苯氧基(倘若该苯氧基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷硫基、苯硫基、(倘若该苯硫基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷基磺酰基、苯磺酰基(倘若该苯磺酰基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷基羰基、羧酸、C1-C6的烷氧基羰基、C1-C6的单烷基氨基羰基、C1-C6的二烷基氨基羰基、C1-C6的酰氨基、C1-C6的卤代烷基、被氰基取代的C1-C6的烷基、被羟基取代的C1-C6的烷基、被氨基取代的C1-C6的烷基、被C1-C6的烷氧基取代的C1-C6的烷基、被C1-C6的卤代烷氧基取代的C1-C6的烷基、被C1-C6的烷硫基取代的C1-C6的烷基、被C1-C6的烷基磺酰基取代的C1-C6的烷基、被C1-C6烷基羰基取代的C1-C6的烷基、被羧酸取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C1-C6的烷基、被C2-C6的烯氧基取代的C1-C6的烷基、被C2-C6的炔氧基取代的C1-C6的烷基、被C2-C6的酰氨基取代的C1-C6的烷基、被C1-C6的烷基磺酰氧基取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C2-C6的烯基、被氰基取代的C2-C6炔基、苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、或被苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基所取代)取代的C1-C6的烷基；X是氧或硫；M是氢、C1-C6的烷基、C2-C6的烯基或C2-C6的炔基；而G是式中A是
或氮，而B和C各自为C1-C4的烷基、C1-C4的烷氧基、C1-C4的卤代烷基、C1-C4的卤代烷氧基、卤素或C1-C4的单烷基氨基。
2.一种具有分子式(II)
3.一种具有分子式(III)
的化合物，式中Q为
或
其中R1、R2、R3、R4和R5各自为氢、C1-C6的烷基、C1-C6的烯基、C2-C6的炔基、卤素、三氟甲基、硝基、氰基、氨基、C1-C6的烷氧基、苯氧基(倘若该苯氧基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷硫基、苯硫基(倘若该苯硫基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷基磺酰基、苯磺酰基(倘若该苯磺酰基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)、C1-C6的烷基羰基、羧酸、C1-C6的烷氧基羰基、C1-C6的单烷基氨基羰基、C1-C6的二烷基氨基羰基、C2-C6的酰氨基、C1-C6的卤代烷基、被氰基取代的C1-C6的烷基、被羟基取代的C1-C6的烷基、被氨基取代的C1-C6的烷基、被C1-C6的烷氧基取代的C1-C6的烷基、被C1-C6的卤代烷氧基取代的C1-C6的烷基、被C1-C6的烷硫基取代的C1-C6的烷基、被C1-C6的烷基磺酰基取代的C1-C6的烷基、被C1-C6的烷基羰基取代的C1-C6的烷基、被羧酸取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C1-C6的烷基、被C2-C6的烯氧基取代的C1-C6的烷基、被C2-C6的炔氧基取代的C1-C6的烷基、被C2-C6的酰氨基取代的C1-C6的烷基、被C1-C6的烷基磺酰氧基取代的C1-C6的烷基、被C1-C6的烷氧基羰基取代的C2-C6的烯基、被氰基取代的C2-C6的炔基、苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)或被苯基(倘若该苯基可被卤素、三氟甲基、C1-C6的烷基、C1-C6的烷氧基或C1-C6的烷氧基羰基取代)取代的C1-C4的烷基；X是氧或硫；而Y是C1-C6的烷基或苯基。
4.一种选择性的除草剂，它包括除草有效量的，由权利要求1所限定的分子式I之化合物或其盐，以及农用载体或稀释剂。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11302988 | 1988-05-10 | ||
| JP113029/88 | 1988-05-10 | ||
| JP250400/88 | 1988-10-04 | ||
| JP32719988 | 1988-12-24 | ||
| JP327199/88 | 1988-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1041592A true CN1041592A (zh) | 1990-04-25 |
Family
ID=26452053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89103148 Pending CN1041592A (zh) | 1988-05-10 | 1989-05-09 | 磺内酰胺磺胺衍生物及除草剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1041592A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102464628A (zh) * | 2010-11-10 | 2012-05-23 | 上海药明康德新药开发有限公司 | 一种环状α,β-不饱和磺酰胺衍生物的制备方法 |
| CN102464627A (zh) * | 2010-11-10 | 2012-05-23 | 上海药明康德新药开发有限公司 | 丙烯基-1,3-磺内酰胺的制备方法 |
| CN104082327A (zh) * | 2014-06-26 | 2014-10-08 | 广东中迅农科股份有限公司 | 一种用于玉米田苗后除草的农药组合物 |
-
1989
- 1989-05-09 CN CN 89103148 patent/CN1041592A/zh active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102464628A (zh) * | 2010-11-10 | 2012-05-23 | 上海药明康德新药开发有限公司 | 一种环状α,β-不饱和磺酰胺衍生物的制备方法 |
| CN102464627A (zh) * | 2010-11-10 | 2012-05-23 | 上海药明康德新药开发有限公司 | 丙烯基-1,3-磺内酰胺的制备方法 |
| CN102464628B (zh) * | 2010-11-10 | 2015-07-01 | 天津药明康德新药开发有限公司 | 一种环状α,β-不饱和磺酰胺衍生物的制备方法 |
| CN104082327A (zh) * | 2014-06-26 | 2014-10-08 | 广东中迅农科股份有限公司 | 一种用于玉米田苗后除草的农药组合物 |
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