CN104147361A

CN104147361A - Traditional Chinese medicine preparation for treating hyperlipidemia

Info

Publication number: CN104147361A
Application number: CN201410428566.4A
Authority: CN
Inventors: 孙衍鹏; 贺军
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-27
Filing date: 2014-08-27
Publication date: 2014-11-19

Abstract

The invention discloses a traditional Chinese medicine preparation for treating hyperlipidemia. Selected raw material medicines includes, by weight, 20-30g of polygonum cuspidatum, 10-20g of hawthorns, 10-20g of dandelion, 10-20g of cassia obtusifolia, 10-20g of polygonatum odoratum, 10-20g of radix polygoni multiflori preparata, 10-20g rosa laevigata michx, 10-20g of salviae miltiorrhizae, 8-12g of fructus herba leonuri, 8-15g of Semen celosiae, 8-12g of chrysanthemum morifolium, 8-12g of astragalus, 8-12g of fried semen raphani, 8-12g of wine-processed rhubarb, 8-12g of rhizoma alismatis, 8-12g of lotus leaves and 8-12g of herba artemisiae scopariae. The traditional Chinese medicine preparation is excellent in medicine compatibility and has effects of nourishing yin and tonifying blood, activating blood and resolving stasis, boosting qi and freeing channels, soothing liver and fortifying spleen, and reducing and resolving fat. The traditional Chinese medicine preparation is definite in curative effects on hyperlipidemia, is free of side effects, is high in curative ratio and is valuable for being popularized and applied clinically.

Description

A kind of Chinese medicine preparation for the treatment of hyperlipidemia

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can treat hyperlipidemia.

Background technology

Hyperlipidemia be due to lipid metabolism or running extremely make one or more lipids of blood plasma higher than being normally called hyperlipidemia, it is a kind of systemic disease, refer to blood cholesterol (TC) or triglyceride (TG) is too high or HDL-C (HDL-C) is too low, modern medicine is referred to as dyslipidemia.

Long-term hyperlipidemia can cause hyperlipidemia, blood vessel wall is slowly adhered to a lot of metabolite, and vessel wall elasticity reduces, and the logical blood ability of blood vessel weakens simultaneously, blood transportation nutrient and oxygen ability reduce, a lot of organs can not get normal nutrition and oxygen supply, and organ dysfunction is impaired gradually, and impaired is the body of gland organ that blood vessel is less at first, long-term blood fat height also can cause the interior environment of blood to degenerate, a lot of immunocytes cannot be survived, and slowly disappear, and cause immunity to reduce.The main harm of hyperlipidemia is to cause atherosclerosis, and then causes numerous relevant diseases, and wherein modal a kind of mortality disease is exactly coronary heart disease.Serious chylomicronemia can cause acute pancreatitis, is another mortality disease.

At present, treat clinically hyperlipidemia and mainly adopt cholic acid binding resin, nicotinic acid class and fibrate drug, this type of medicine instant effect, but cure the symptoms, not the disease, easily recurrence, be difficult to radical cure, and easily there is erubescence, pruritus, stomach discomfort, dyspepsia in long-term taking, blood sugar increasing, blood uric acid raises, the side effect such as peptic ulcer, prolonged application easily causes liver function injury.Therefore, give full play to characteristic and the few advantage of herbal toxic effect of differentiation of tcm, application compound traditional Chinese medicine treatment hyperlipidemia, has wide ground prospect.

Summary of the invention

The present invention has overcome the technical deficiency of existence aspect treatment hyperlipidemia at present, and a kind of instant effect, short treating period, the thorough Chinese medicine preparation of curing, being difficult for recurrence and having no side effect are provided.

The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of hyperlipidemia, it is characterized in that, and described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

Rhizoma Polygoni Cuspidati 20-30 gram, Fructus Crataegi 10-20 gram, Herba Taraxaci 10-20 gram, Semen Cassiae 10-20 gram, Rhizoma Polygonati Odorati 10-20 gram, Radix Polygoni Multiflori Preparata 10-20 gram, Fructus Rosae Laevigatae 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Fructus Leonuri 8-12 gram, Semen Celosiae 8-15 gram, Flos Chrysanthemi 8-12 gram, Radix Astragali 8-12 gram, Semen Raphani (parched) 8-12 gram, Radix et Rhizoma Rhei (stir-fried with wine) 8-12 gram, Rhizoma Alismatis 8-12 gram, Folium Nelumbinis 8-12 gram, Herba Artemisiae Scopariae 8-12 gram.

As this kind of prioritization scheme:

Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

20 grams of Rhizoma Polygoni Cuspidati, 10 grams of Fructus Crataegis, 10 grams of Herba Taraxacis, 10 grams of Semen Cassiae, 10 grams of Rhizoma Polygonati Odorati, 10 grams of Radix Polygoni Multiflori Preparata, 10 grams of Fructus Rosae Laevigatae, 10 grams of Radix Salviae Miltiorrhizaes, 8 grams of Fructus Leonuri, 8 grams of Semen Celosiae, 8 grams of Flos Chrysanthemi, 8 grams of the Radixs Astragali, 8 grams of Semen Raphani (parched), 8 grams of Radix et Rhizoma Rhei (stir-fried with wine), 8 grams of Rhizoma Alismatis, 8 grams, Folium Nelumbinis, 8 grams of Herba Artemisiae Scopariaes.

As this kind of prioritization scheme:

25 grams of Rhizoma Polygoni Cuspidati, 15 grams of Fructus Crataegis, 15 grams of Herba Taraxacis, 15 grams of Semen Cassiae, 15 grams of Rhizoma Polygonati Odorati, 15 grams of Radix Polygoni Multiflori Preparata, 15 grams of Fructus Rosae Laevigatae, 15 grams of Radix Salviae Miltiorrhizaes, 10 grams of Fructus Leonuri, 12 grams of Semen Celosiae, 10 grams of Flos Chrysanthemi, 10 grams of the Radixs Astragali, 10 grams of Semen Raphani (parched), 10 grams of Radix et Rhizoma Rhei (stir-fried with wine), 10 grams of Rhizoma Alismatis, 10 grams, Folium Nelumbinis, 10 grams of Herba Artemisiae Scopariaes.

As this kind of prioritization scheme:

30 grams of Rhizoma Polygoni Cuspidati, 20 grams of Fructus Crataegis, 20 grams of Herba Taraxacis, 20 grams of Semen Cassiae, 20 grams of Rhizoma Polygonati Odorati, 20 grams of Radix Polygoni Multiflori Preparata, 20 grams of Fructus Rosae Laevigatae, 20 grams of Radix Salviae Miltiorrhizaes, 12 grams of Fructus Leonuri, 15 grams of Semen Celosiae, 12 grams of Flos Chrysanthemi, 12 grams of the Radixs Astragali, 12 grams of Semen Raphani (parched), 12 grams of Radix et Rhizoma Rhei (stir-fried with wine), 12 grams of Rhizoma Alismatis, 12 grams, Folium Nelumbinis, 12 grams of Herba Artemisiae Scopariaes.

The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, get its medicine juice according to the method for the fried Chinese medicine of tradition, 1 dose of every day, add clear water 400ml, soak 30 minutes, first boil with high heat rear use taking liquid 150ml at a simmer; Take again medicinal liquid 150ml.By 2 liquid medicine mixings, point morning, late 2 decoction being taken warmly.30 days be 1 course for the treatment of 1 dose of every day.

The raw material Chinese medicine of above-mentioned Chinese medicine preparation:

Rhizoma Polygoni Cuspidati, bitter in the mouth, cold in nature; Return liver, gallbladder, lung meridian.There is promoting blood circulation and stopping pain, heat-clearing and toxic substances removing, effect of preventing phlegm from forming and stopping coughing.

Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.There is promoting digestion and removing stagnation, effect of promoting blood circulation to remove blood stasis.

Herba Taraxaci, sweet in the mouth, micro-hardship, property is flat; Return liver, stomach warp.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of row water diuresis.

Semen Cassiae, bitter in the mouth, sweet, salty, cold nature; Enter liver, kidney, large intestine channel.There is loosening bowel to relieve constipation, blood fat reducing improving eyesight, effect of diuretic relieving constipation.

Rhizoma Polygonati Odorati, sweet in the mouth, property is flat; Attach to the lung and stomach meridians.There is nourishing YIN and moistening the lung, effect of the nourishing the stomach of promoting the production of body fluid.

Radix Polygoni Multiflori Preparata, bitter in the mouth, puckery, sweet, slightly warm in nature; Return liver, kidney channel.Having effect that liver and kidney tonifying, beneficial essence are enriched blood, is superior nourishing medicine.

Fructus Rosae Laevigatae, sour in the mouth, puckery, property is flat.Return kidney, bladder, large intestine channel.There is controlling nocturnal emission with astringent drugs reducing urination, effect of relieving diarrhea with astringents.

Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature; GUIXIN, pericardium, Liver Channel.There is blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, effect of nourishing blood to tranquillize the mind.

Fructus Leonuri, acrid in the mouth, hardship, cold nature; GUIXIN bag, Liver Channel.There is promoting blood flow to regulate menstruation, effect of wind and heat dispersing.

Semen Celosiae, bitter in the mouth, cold nature; Return Liver Channel.There is liver heat removing and let out fire, effect of improving acuity of vision and removing nebula.

Flos Chrysanthemi, taste is micro-pungent, sweet, bitter, cold nature; Return lung, Liver Channel.There is dispelling wind and heat pathogens, liver heat removing and eyesight improving, invigorating the spleen and regulating the stomach, adjusts the effects such as blood fat.

The Radix Astragali, sweet in the mouth, slightly warm in nature; Return spleen, lung meridian.There is benefiting QI for strengthening the superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, effect of inducing diuresis to remove edema.

Semen Raphani (parched), acrid in the mouth, sweet, property is flat; Return spleen, stomach, lung meridian.There is the de-swelling of helping digestion, effect of lowering the adverse-rising QI to resolve phlegm.

Radix et Rhizoma Rhei (stir-fried with wine), bitter in the mouth, cold in nature.Return stomach, spleen, large intestine, liver, pericardium channel.There is purging heat to relax the bowels, removing toxicity for eliminating carbuncles, effect that clots absorbing stimulates the menstrual flow.

Rhizoma Alismatis, sweet in the mouth, light, cold in nature; Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.

Folium Nelumbinis, bitter in the mouth, puckery, property is flat; GUIXIN, liver, spleen channel.There is clearing away summer-heat, sending up the lucid YANG, effect of cooling blood for hemostasis.

Herba Artemisiae Scopariae, bitter in the mouth, cold nature; Return spleen, stomach, liver, gallbladder meridian.There is clearing away heat-damp and promoting diuresis, effect of promoting the function of the gallbladder to alleviate jaundice.

Hyperlipidemia can belong to the categories such as Chinese medicine " expectorant is turbid, blood stasis ", many with eating and drinking without temperance, have a liking for eat delicious food savoury and visceral dysfunction relevant.Chinese medicine thinks, primary disease is because spleen feritin void, water-damp not being transformed, the expectorant stasis of blood enter due to blood, and therefore eliminate the phlegm dampness removing, Zishen Qinggan, promoting blood circulation to remove obstruction in the collateral of spleen invigorating is the key for the treatment of hyperlipidemia.

In Chinese medicine preparation of the present invention, Rhizoma Polygoni Cuspidati, Folium Nelumbinis can heat-clearing and toxic substances removing, suppressing the hyperactive liver and subsiding YANG, expelling phlegm for arresting cough; Fructus Crataegi, Semen Raphani (parched) can promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis; Herba Taraxaci, the feasible water diuresis of Semen Cassiae, blood fat reducing improving eyesight; Rhizoma Polygonati Odorati, the Radix Astragali can nourishing YIN and moistening the lung, spleen invigorating profit stomach; Radix Polygoni Multiflori Preparata, Fructus Rosae Laevigatae can liver and kidney tonifying, and beneficial essence is enriched blood, righting primordial QI reinforcing; Radix Salviae Miltiorrhizae, Fructus Leonuri can wind and heat dispersing, promoting blood flow to regulate menstruation; Semen Celosiae, Flos Chrysanthemi can liver heat removing be let out fire, and invigorating the spleen and regulating the stomach is adjusted blood fat; Radix et Rhizoma Rhei (stir-fried with wine), Rhizoma Alismatis, Herba Artemisiae Scopariae can promoting diuresis to eliminate damp pathogen, expel the heat-evil treating stranguria, and removing toxicity for eliminating carbuncles.All medicine compatibilities are superior, play altogether invigorating the spleen and regulating the stomach, the dampness removing that eliminates the phlegm, nourishing the liver lung heat clearing, promoting blood circulation to remove obstruction in the collateral, effect of the body resistance strengthening and constitution consolidating, after drug administration, hyperlipidemia pathogenesis can effectively hit, can obviously reduce the blood lipid level of hyperlipemia, and have no adverse reaction, curative effect is safe and reliable, clinic promotion and application.

For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 2007-2011 out-patient to carry out clinical trial, formulate into group standard as follows: 1, cholesterol (TC) >=5.7nmol/L; 2, triacylglycerol (TG) >=1.7nmol/L, low density lipoprotein, LDL (LDL-C) >=3.6nmol/L, HDL-C (HDL-C)≤1.0nmol/L.Enter altogether group 86 examples, male 49 examples, female's 37 examples; Age 24-80 year, average 40 years old; Course of disease 2.5-25, average 9.1 years.All patient's random packet treatment groups and matched group, every group of 60 examples.Two groups of patients' age, sex, body weight, sick time, disease symptom isobase data Epidemiological Analysis by statistics, difference not statistically significant (P > 0.05), has comparability.

Criterion of therapeutical effect:

Clinical efficacy standard (with reference to new Chinese medicine guideline of clinical investigations):

Effective: TC declines >=20%, or TG decline >=40%, or HDL-C rising >=0.2mmol/L, or AI declines >=20%;

Effective: TC decline 10%-19%, or TG decline 20%-39%%, or HDL-C rising 0.1-0.25mmol/L, or AI decline 10%-19%;

Invalid: after treatment, lipids detection is not improved or improves effective standard that do not reach.

Therapeutic Method:

Treatment group is taken Chinese medicine preparation of the present invention, and 1 dose of every day, all taste Chinese medicine adds clear water 400ml after mixing, and soaks 30 minutes, first boils with high heat rear use taking liquid 150ml at a simmer; Take again medicinal liquid 150ml.By 2 liquid medicine mixings, point morning, late 2 decoction being taken warmly.30 days be 1 course for the treatment of 1 dose of every day.The oral simvastatin sheet of matched group.8 o'clock decoction being taken at a draught 20mg (production of Hangzhou Mo Shadong pharmaceutical Co. Ltd), all treat 8 weeks for two groups every night.The period in a medicine diet that does as usual, stops using other to the influential medicine of blood fat.

Efficacy result:

1. clinical efficacy result: after treatment, in treatment group, TC index, effective 28 examples, effective 11 examples, invalid 4 examples, effective percentage reaches 90.7%; TG index, effective 32 examples, effective 9 examples, invalid 2 examples, effective percentage reaches 95.3%.In matched group, TC index, effective 20 examples, effective 12 examples, invalid 11 examples, effective percentage 74.4%; TG index, effective 16 examples, effective 17 examples, invalid 10 examples, effective percentage reaches 76.7%.Two groups of differences have significance (P < 0.05).Detailed results is in table 1.

Table 1: clinical efficacy result synopsis after two groups of case treatments

2. blood lipids index comparison:

By the detection of TC, TG index in therapeutic process, after treatment 4 weeks and treatment after 8 weeks, treatment group curative effect of medication is obviously better than matched group, has compared significant difference (P < 0.01) for two groups.Detailed results is in table 2.

Table 2: two groups of case blood lipids index synopsis

3. answer for bad:

In treatment, there is not gastrointestinal upset and other obvious adverse reaction in treatment group, and matched group has 12 examples that gastrointestinal upsets occur, and one crosses property transaminase 9 examples that raise.

Result shows, the Chinese medicine preparation of the present invention pathogenesis that can effectively hit can strengthening spleen, tonifying kidney after taking, damp eliminating is reduced phlegm, blood circulation promoting and blood stasis dispelling, blood fat reducing and blood viscosity, improve body microcirculation, the diseases such as treatment hyperlipidemia and the dizziness causing, headache, insomnia and numb limbs and tense tendons are had to good efficacy.

Detailed description of the invention

Embodiment 1: a kind of Chinese medicine preparation for the treatment of hyperlipidemia, choose 20 grams of Rhizoma Polygoni Cuspidati, 10 grams of Fructus Crataegis, 10 grams of Herba Taraxacis, 10 grams of Semen Cassiae, 10 grams of Rhizoma Polygonati Odorati, 10 grams of Radix Polygoni Multiflori Preparata, 10 grams of Fructus Rosae Laevigatae, 10 grams of Radix Salviae Miltiorrhizaes, 8 grams of Fructus Leonuri, 8 grams of Semen Celosiae, 8 grams of Flos Chrysanthemi, 8 grams of the Radixs Astragali, 8 grams of Semen Raphani (parched), 8 grams of Radix et Rhizoma Rhei (stir-fried with wine), 8 grams of Rhizoma Alismatis, 8 grams, Folium Nelumbinis, 8 grams of Herba Artemisiae Scopariaes.

Embodiment 2: a kind of Chinese medicine preparation for the treatment of hyperlipidemia, choose 25 grams of Rhizoma Polygoni Cuspidati, 15 grams of Fructus Crataegis, 15 grams of Herba Taraxacis, 15 grams of Semen Cassiae, 15 grams of Rhizoma Polygonati Odorati, 15 grams of Radix Polygoni Multiflori Preparata, 15 grams of Fructus Rosae Laevigatae, 15 grams of Radix Salviae Miltiorrhizaes, 10 grams of Fructus Leonuri, 12 grams of Semen Celosiae, 10 grams of Flos Chrysanthemi, 10 grams of the Radixs Astragali, 10 grams of Semen Raphani (parched), 10 grams of Radix et Rhizoma Rhei (stir-fried with wine), 10 grams of Rhizoma Alismatis, 10 grams, Folium Nelumbinis, 10 grams of Herba Artemisiae Scopariaes.

Embodiment 3: a kind of Chinese medicine preparation for the treatment of hyperlipidemia, choose 30 grams of Rhizoma Polygoni Cuspidati, 20 grams of Fructus Crataegis, 20 grams of Herba Taraxacis, 20 grams of Semen Cassiae, 20 grams of Rhizoma Polygonati Odorati, 20 grams of Radix Polygoni Multiflori Preparata, 20 grams of Fructus Rosae Laevigatae, 20 grams of Radix Salviae Miltiorrhizaes, 12 grams of Fructus Leonuri, 15 grams of Semen Celosiae, 12 grams of Flos Chrysanthemi, 12 grams of the Radixs Astragali, 12 grams of Semen Raphani (parched), 12 grams of Radix et Rhizoma Rhei (stir-fried with wine), 12 grams of Rhizoma Alismatis, 12 grams, Folium Nelumbinis, 12 grams of Herba Artemisiae Scopariaes.

Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:

Case 1

Find pleasure in certain, female, 46 years old.Patient is when before 1 year, unit organization is had a medical check-up, show T-CHOL 6.53, apolipoprotein B 1.12, HDL-C 2.00, low-density lipoprotein cholesterol 3.74, serum lipoprotein (a) 458.7, patient, with symptoms such as headache, insomnia, numb limbs and tense tendons, is diagnosed as hyperlipidemia.Upon somebody's introduction, take medicine of the present invention and treat, after 1 course for the treatment of, patient sign obviously improves, and checks that cholesterol, high and low density lipoprotein cholesterol and serum lipoprotein tool have clear improvement; After 2 courses for the treatment of, all diseases of patient disappear, health check-up demonstration, and T-CHOL drops to 4.53, HDL-C 1.63, it is normal that patient body recovers.Follow up a case by regular visits to half a year without recurrence.

Case 2

Chen, man, 33 years old.It is hyperlipidemia that patient haves a medical check-up recent years always, there is no any malaise symptoms, low density lipoprotein, LDL 4.4, T-CHOL 6.23, triglyceride 1.92, sundry item is normal, it is triglyceride height higher (2.1) that the first two years is had a medical check-up, and once uses fenofibrate to treat, and is all to eat up medicine just to have fallen at every turn, drug withdrawal is high again, and disease is shown effect repeatedly.Upon somebody's introduction, taking medicine of the present invention treats, after 2 courses for the treatment of, patient sign obviously improves, check that cholesterol, high and low density lipoprotein cholesterol and serum lipoprotein tool have clear improvement, check and show that T-CHOL drops to 4.48, low density lipoprotein, LDL 3.65, triglyceride 1.42, it is normal that patient body recovers.Follow up a case by regular visits to half a year without recurrence.

Case 3:

Zhao, man, 55 years old.Patient suffers from hyperlipidemia more than 2 years, and patient often has a dizzy spell, and sleeps less.Red tongue, yellow and thin fur, pulse condition stringy and rapid pulse, checks blood fat serum cholesterol 300mg% on an empty stomach, B-lipoprotein 501mg%,, cardiopulmonary are normal, liver spleen does not touch.Once adopted the mode such as massage, take medicine to treat repeatedly, DeGrain.Upon somebody's introduction, start to take medicine of the present invention and treat, after 1 course for the treatment of, patient sign improves obviously; Continue to take 1 check course for the treatment of and show, Diagnostic Value of Fasting Serum cholesterol is down to 150mg%, and B-lipoprotein is down to 265%, all right.Continue to take 1 course for the treatment of and consolidated, patient's recovery from illness.Follow up a case by regular visits to half a year without recurrence.

Claims

1. a Chinese medicine preparation for the treatment of hyperlipidemia, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:

4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion: