CN104147357A - Compound Chinese caterpillar fungus oral preparation and preparation method thereof - Google Patents
Compound Chinese caterpillar fungus oral preparation and preparation method thereof Download PDFInfo
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- CN104147357A CN104147357A CN201410409194.0A CN201410409194A CN104147357A CN 104147357 A CN104147357 A CN 104147357A CN 201410409194 A CN201410409194 A CN 201410409194A CN 104147357 A CN104147357 A CN 104147357A
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Abstract
The invention belongs to the preparation of a health care preparation, and especially relates to a compound Chinese caterpillar fungus oral preparation and a preparation method thereof. The method comprises the following steps: cleansing Cordyceps sinensis, cordyceps militaris and gen-seng, drying at low temperature to prepare submicron powder; extracting Radix Astragali and polygonatum rhizome decoction pieces through purified water heat backflow, filtering and performing vacuum concentration, and performing spray drying to obtain the extract product dried powder; mixing soybean peptide, taurine and vitamin C powder, and then mixing with submicron powder, the extract product dried powder and an auxiliary material to prepare the oral preparation. The compound Chinese caterpillar fungus oral preparation solves the problem that the current chronic fatigue syndrome can not be effectively improved, the test showsthat the compound Chinese caterpillar fungus oral preparation can effectively used for limb fatigue due to high strength motion, competitive ability can be improved and increased when the athletes takes the oral preparation during a match period, oxygen and energy supply during a violent match can be enhanced, after frequent overwrought training, cerebral cortex function and nerve-body fluid function can be adjusted, organs and system function state can be recovered, and condition that fatigue is transferred to over fatigue can be avoided.
Description
Technical field
The invention belongs to the preparation of health preparation, refer to especially a kind of compound Chinese caterpillar fungus oral formulations and preparation thereof.
Background technology
Fatigue be body under certain environment, be engaged in for a long time too heavy, nervous muscle power or mental work, and cause a kind of physiological phenomenon that working performance obviously reduces, subjective generally with tired out sense.Tired taking the form of is diversified, can be divided into Four types substantially: the one, and indivedual organs are tired, often occur in the nervous operation that only needs indivedual organs or limbs to participate in, as keystroke dish etc.The 2nd, how whole body fatigue, because of due to heavy physical labor, often have special sensation and behavior, as whole-body muscle and joint aches, tired and drowsiness etc.The 3rd, intelligence fatigue, causes because continuing nervous mental work, its feature is dizzy, weak, emotional, of flaccid muscles, drowsiness or insomnia.The 4th, technical fatigue, is more common in brain body use, and neural, spiritual high-strung operation, as driven.Fatigue can also be divided into mental fatigue and neural fatigue, muscle, metabolism, emotion, around tired and acute and chronic fatigue etc.Modern society is increasingly competitive, operating pressure and Psychological stimulation constantly increase, the athletic competition of various athleticses, the training of over loading often make human body in overtired sub-health state, and then develop into chronic fatigue syndrome.Chronic fatigue syndrome is to perplex in recent ten years a kind of modern civilization diseases of developed country, chronic fatigue syndrome can cause multiple malfunction, so that cause body major injury and disease, in the U.S., chronic fatigue syndrome is paid much attention to, classify this disease as the first kind and catch, be classified as a prevention classification with cholera, malaria, hepatitis C and tuberculosis.China also has people more than half to suffer from chronic fatigue syndrome at present, and this disease distributes especially more in city, accounts for 70% of urban population.
Gathering of immune destruction and human free radical is the tired major reason occurring, and therefore, enhancing human body immunity power, removing free radical are the important channels of resisting fatigue.In recent years rehabilitation expert and physical culture scholar finding always can antioxidation, improve immunocompetence, delay or food or the natural drug of allaying tiredness fast.Motherland's theory of medicine is thought " the kidney being the origin of congenital constitution, the spleen being the foundation of acquired constitution ", should pay attention to strengthening the body resistance, and enhancing immunity multiselect is adjusted the deficiency of yin-Yang, QI and blood, body fluid, enhancing body resistance against diseases with the square medicine with the kidney invigorating, spleen invigorating; Motherland's medical science thinks that " fatigue " belongs to the category of " labor ", " asthenia ", in < <, through Plain Questions, lift pain opinion > > speech: " overexertion leading to consumption of QI ", i.e. work or motion can cause body YANG QI deficiency and the aching and limp deficiency of vital energy syndrome such as weak, tired of the limbs that cause, form tired.
Summary of the invention
One of object of the present invention is to provide a kind of compound Chinese caterpillar fungus oral formulations.
Two of object of the present invention is to provide a kind of preparation method of compound Chinese caterpillar fungus oral formulations.
Overall technology design of the present invention is:
A compound Chinese caterpillar fungus oral formulations, this oral formulations is made by the component of following mass fraction:
Cordyceps superfine powder 300-1000; Cordyceps militaris (L.) Link. superfine powder 500-1500; Ginseng submicron powder 500-1500; Radix Astragali 1500-2500; Rhizoma Polygonati 1500-2500; Soybean protein peptide 500-1500; Taurine 500-1500; Vitamin C 100-300.
The preparation method of compound Chinese caterpillar fungus oral formulations, comprises following processing step:
The preparation of A, Cordyceps superfine powder, Cordyceps militaris (L.) Link. superfine powder, ginseng submicron powder: select after Cordyceps, Cordyceps militaris (L.) Link., the clean system of Radix Ginseng, in 40-50 ℃ of oven drying at low temperature, dried material is pulverized and made superfine powder with super micron mill;
The preparation of B, the Radix Astragali, Rhizoma Polygonati extract xeraphium: the Radix Astragali, Rhizoma Polygonati decoction pieces are extracted 1-3 time with purified water hot reflux, each 1-3 hour, filtration merging filtrate sieves, and while being evaporated to 60 ℃, the relative density of concentrated solution is 1.05-1.08, and spraying is dried to obtain extract xeraphium;
C, soybean protein peptide, taurine and vitamin C powder are mixed in proportion after, after being mixed with the superfine powder of preparing in steps A, B and extract xeraphium and adjuvant, make oral formulations.
The supplementary product kind, consumption and the technique that because of the dosage form of processing as required, add belong to prior art, and applicant does not repeat them here.
For improving effect, reduce the consumption of valuable raw material, Cordyceps, Cordyceps militaris (L.) Link., Radix Ginseng adopt superfine powder as addition manner.
Concrete technology contents of the present invention also has:
More preferred technical scheme is that this oral formulations is made by the component of following mass fraction:
Cordyceps superfine powder 300-700; Cordyceps militaris (L.) Link. superfine powder 800-1200; Ginseng submicron powder 800-1200; Radix Astragali 1800-2200; Rhizoma Polygonati 1800-2200; Soybean protein peptide 800-1200; Taurine 800-1200; Vitamin C 150-250.
Highly preferred technical scheme is that this oral formulations is made by the component of following mass fraction:
Cordyceps superfine powder 500; Cordyceps militaris (L.) Link. superfine powder 1000; Ginseng submicron powder 1000; The Radix Astragali 2000; Rhizoma Polygonati 2000; Soybean protein peptide 1000; Taurine 1000; Vitamin C 200.
In described steps A, grinding time is 5-10 minute.
In described step B, sieving is 300 mesh sieves, and spray-dired condition is inlet temperature 150-190 ℃, leaving air temp 80-100 ℃, relatively pressure-10～-40Pa.
In the present invention, each raw material role is as follows:
It is raw material that the present invention selects Chinese crude drug without any side effects, Cordyceps has disease and the physical weakness such as tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm, dyspnea due to deficiency, chronic cough, spitting of blood, spontaneous sweating, impotence and seminal emission, soreness of waist and knee joint, prolonged deficiency is multiple after being ill, Cordyceps militaris (L.) Link. is that its amino acid content of ideal substitute of Cordyceps is low compared with natural cs content, but cordycepin, cordycepic acid, adenosine content are high compared with natural cs, can make up the defect of natural cs.Radix Ginseng is Chinese traditional rare Chinese medicine, enters spleen, lung, the heart, kidney channel, strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourishes blood, and has good immunostimulant antifatigue effect; The Radix Astragali is containing astragalus polysaccharides, flavone compound, saponin component etc., has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, cures mainly the cards such as the deficiency of vital energy is weak, sinking of QI of middle-JIAO.Rhizoma Polygonati has the merit of boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying, can be used for treating weakness of the spleen and stomach, fatigue and asthenia, and above-mentioned Chinese crude drug not only has good immune-enhancing activity, also has good antioxidant activity, can effectively remove free radical.The present invention adopts traditional traditional tonic medicine material; assistant is with soybean protein peptide, taurine and vitamin C; can effectively remove free radical, improve immunity; also can play and supplement rapidly aminoacid, the effect of allaying tiredness fast, be specially adapted to larger staff and the person in middle and old age's sub-health population of athlete, pressure of high pressure training.
For verifying effect of the present invention, applicant has carried out following test:
Test 1, the experiment of mice burden swimming endurance
Observe mice and take swimming continuance time and the hypoxia endurance time variation after the compound Chinese caterpillar fungus oral formulations in the present invention.Select 20 of healthy male mouse of kunming, body weight 18-22g, is divided into matched group and experimental group at random, 10 every group.Experimental group gives the oral formulations of the compound Chinese caterpillar fungus in the present invention by 2.0mg/g body weight gavage, and matched group gives distilled water, continuously 30d; After last administration 30min, carry out swimming with a load attached to the body breakdown test, every mice institute loading weight is its body weight 5%, ties up about 2-3 thoracic vertebra place after forelimb, and elasticity is as the criterion with not slippage, the sea water bath of putting into (30 ± 1) ℃ after tying up at one time, records its swimming lethal time.
Compare with matched group, experimental mice swimming with a load attached to the body time phenomenal growth (P<0.01), show that compound Chinese caterpillar fungus oral formulations of the present invention can improve the swimming with a load attached to the body ability of mice, significantly strengthen the motor capacity of mice, concrete outcome is in Table 1.
Table 1 mice burden swimming endurance experimental result (
n=10)
Test 2, the experiment of mice anti-hypoxia
Observe mice and take the variation of the time-to-live in airtight anoxia environment after compound Chinese caterpillar fungus oral formulations in the present invention.Select 20 of healthy male mouse of kunming, body weight 18-22g, is divided into matched group and experimental group at random, 10 every group.Experimental group gives compound Chinese caterpillar fungus oral formulations in the present invention by 2.0mg/g body weight gavage, and matched group gives distilled water, continuously 30d; After last gavage 30min, mice is dropped in the wide mouthed bottle of 500mL, airtight, record the mouse survival time.
Result of study shows, compares with matched group, and experimental mice anti-anoxia ability obviously strengthens (P<0.01), the results are shown in Table 2.
Table 2 mice anti-hypoxia experimental result (
n=10)
Test 3, acute cerebral ischemia experiment
Observe mice and take the variation of time-to-live after acute cerebral ischemia after compound Chinese caterpillar fungus oral formulations in the present invention.Select 20 of healthy male mouse of kunming, body weight 18-22g, is divided into matched group and experimental group at random, 10 every group.Experimental group gives compound Chinese caterpillar fungus oral formulations in the present invention by 2.0mg/g body weight gavage, and matched group gives distilled water, continuously 30d; After last gavage 1h, from cervical region, mice is breaked end, after immediate record mice broken end to the dwell time of breathing of dehiscing.
Result of study shows, compares with matched group, and the time-to-live after experimental mice acute cerebral ischemia obviously extends (P<0.01), the results are shown in Table 3.
The impact that table 3 is tested mouse brain ischemia (
n=10)
Test 4, the impact on Immunity of the athletes, anti-fatigue ability and motor capacity
1, physical data and method
This research has been compared middle-distance runner's pre-games stage of preparation fixed quantitative load and has been taken in the present invention that immunologic function after compound Chinese caterpillar fungus oral formulations, physiology of exercise are biochemical, the effect observation of exercise fatigue index.With Hebei Institute of Physical Education middle-distance race specialized movement person 40 object of study by name, wherein male is 30, and 10 of women all, without endocrinopathy and family's medical history, all sign tested Informed Consent Form.Adopt double blind experiment method, Male movement person, women sport person are divided into experimental group and comfort group at random, every group of 20 people, two groups of M-Fs are identical: oral this product 8g/d, take at twice, take continuously 30d.Experimental session, all experimenters all do not take any other medicine.
IgA, IgG, IgM and CD3+, CD4+, CD8+ and the CD4+/CD8+ value of the person of seesawing taken in record, observes the immune-enhancing activity of product; Mensuration is taken rear athletic anaerobic power, maximal oxygen uptake, the impact of analytic product on Athletes ability; Mensuration is taken rear serum testosterone cellulose content, serum cortisol content, blood urea nitrogen, creatine kinase and psychological fatigue questionnaire (ABQ) scoring, the resisting fatigue effect of analytic product;
Date processing adopts SPSS16.0, relatively adopts variance analysis and t check between group, and P<0.05 represents that difference has statistical significance, and P<0.01 represents that difference has extremely significantly meaning.
2, result of study
2.1, the impact on athlete's immune indexes
Athletic body immunity result of study is shown, in the present invention, compound Chinese caterpillar fungus oral formulations can improve the level of Immunoglobulin IgA, IgG, IgM in body, can significantly improve CD3+, CD4+ and CD4+/CD8+, show that compound Chinese caterpillar fungus oral formulations product in the present invention can effectively improve the immunologic function of body, the results are shown in Table 4-5.
The impact of table 4 on athlete's immune indexes
The impact of table 5 on athlete's immune indexes
2.2 impacts on motor capacity and psychological fatigue degree
Result of study shows can increase athletic anaerobic power and maximal oxygen uptake, alleviates athletic psychological fatigue degree, compares with placebo group, the athletic anaerobic power of experimental group significantly increases, psychological fatigue degree alleviates, and between group, relatively significance has statistical significance, the results are shown in Table 6.
The impact of table 6 on athlete's anaerobic power, maximal oxygen uptake and psychological fatigue degree
* represent P<0.05, after taking medicine, experimental group has been compared significant difference with comfort group
2.3, the impact on the level of blood urea nitrogen, creatine kinase and serum cortisol
Blood urea nitrogen, creatine kinase and serum cortisol have reflected athletic exercise load and fatigue state, these index levels are higher, organism fatigue degree is higher, in result of study discovery the present invention, compound Chinese caterpillar fungus oral formulations can obviously reduce the level of these indexs, between group, relatively significance has statistical significance, shows that in the present invention, compound Chinese caterpillar fungus oral formulations can effectively reduce relieving sports fatigue.Concrete outcome is in Table 7.
The impact of table 7 on the level of athlete's blood urea nitrogen, creatine kinase and serum cortisol
The substantive distinguishing features that the present invention is obtained and significant technological progress are:
Compound Chinese caterpillar fungus oral formulations in the present invention can fill blood, regulate yin-yang, regains one's strength rapidly.Can effectively resist the limbs fatigue that high-intensity exercise causes.Test shows, athlete takes in the present invention after compound Chinese caterpillar fungus oral formulations between match period, can improve competitive ability, makes the metabolic capacity of each system vigorous, the supply of oxygen and energy while promoting violent match, the maximum potential of performance body.And athletes, after the training of hypertonicity frequently, can regulate cerebral cortex function and regulate nerve-body fluid function, and the functional status of each organ, system is restored, avoid being proceeded to by fatigue overtired, cause occurring pathological change.
The specific embodiment
Below in conjunction with embodiment, the present invention is described further; but not as a limitation of the invention; the content that protection scope of the present invention is recorded with claim is as the criterion, and any equivalence techniques means of making according to description are replaced, and all do not depart from protection scope of the present invention.
Embodiment 1
The overall technical architecture of the present embodiment is:
Cordyceps superfine powder 1000; Cordyceps militaris (L.) Link. superfine powder 1500; Ginseng submicron powder 1500; The Radix Astragali 2500; Rhizoma Polygonati 2500; Soybean protein peptide 1500; Taurine 1500; Vitamin C 300.
The preparation method of compound Chinese caterpillar fungus oral formulations, comprises following processing step:
The preparation of A, Cordyceps superfine powder, Cordyceps militaris (L.) Link. superfine powder, ginseng submicron powder: select after Cordyceps, Cordyceps militaris (L.) Link., the clean system of Radix Ginseng, in 40-50 ℃ of oven drying at low temperature, dried material is pulverized and made superfine powder with super micron mill;
The preparation of B, the Radix Astragali, Rhizoma Polygonati extract xeraphium: the Radix Astragali, Rhizoma Polygonati decoction pieces are extracted 1-3 time with purified water hot reflux, each 1-3 hour, filtration merging filtrate sieves, and while being evaporated to 60 ℃, the relative density of concentrated solution is 1.05-1.08, and spraying is dried to obtain extract xeraphium;
C, soybean protein peptide, taurine and vitamin C powder are mixed in proportion after, after being mixed with the superfine powder of preparing in steps A, B and extract xeraphium and adjuvant, make oral formulations.
The supplementary product kind, consumption and the technique that because of the dosage form of processing as required, add belong to prior art, and applicant does not repeat them here.
In described steps A, grinding time is 5-10 minute.
In described step B, sieving is 300 mesh sieves, and spray-dired condition is inlet temperature 150-190 ℃, leaving air temp 80-100 ℃, relatively pressure-10～-40Pa.
Embodiment 2
The difference of the present embodiment and embodiment 1 is:
Cordyceps superfine powder 300; Cordyceps militaris (L.) Link. superfine powder 500; Ginseng submicron powder 500; The Radix Astragali 1500; Rhizoma Polygonati 1500; Soybean protein peptide 500; Taurine 500; Vitamin C 100.
All the other contents are with embodiment 1.
Embodiment 3
The difference of the present embodiment and embodiment 1 is:
Cordyceps superfine powder 800; Cordyceps militaris (L.) Link. superfine powder 1000; Ginseng submicron powder 1000; The Radix Astragali 2000; Rhizoma Polygonati 2000; Soybean protein peptide 1000; Taurine 1000; Vitamin C 200.
All the other contents are with embodiment 1.
Embodiment 4
Cordyceps superfine powder 800; Cordyceps militaris (L.) Link. superfine powder 1200; Ginseng submicron powder 900; The Radix Astragali 1800; Rhizoma Polygonati 1800; Soybean protein peptide 600; Taurine 1200; Vitamin C 250.
Embodiment 5
Cordyceps superfine powder 500; Cordyceps militaris (L.) Link. superfine powder 1000; Ginseng submicron powder 1000; The Radix Astragali 2000; Rhizoma Polygonati 2000; Soybean protein peptide 1000; Taurine 1000; Vitamin C 200.
Claims (6)
1. a compound Chinese caterpillar fungus oral formulations, is characterized in that this oral formulations made by the component of following mass fraction:
Cordyceps superfine powder 300-1000; Cordyceps militaris (L.) Link. superfine powder 500-1500; Ginseng submicron powder 500-1500; Radix Astragali 1500-2500; Rhizoma Polygonati 1500-2500; Soybean protein peptide 500-1500; Taurine 500-1500; Vitamin C 100-300.
2. compound Chinese caterpillar fungus oral formulations according to claim 1, is characterized in that this oral formulations made by the component of following mass fraction:
Cordyceps superfine powder 300-700; Cordyceps militaris (L.) Link. superfine powder 800-1200; Ginseng submicron powder 800-1200; Radix Astragali 1800-2200; Rhizoma Polygonati 1800-2200; Soybean protein peptide 800-1200; Taurine 800-1200; Vitamin C 150-250.
3. compound Chinese caterpillar fungus oral formulations according to claim 1, is characterized in that this oral formulations made by the component of following mass fraction:
Cordyceps superfine powder 500; Cordyceps militaris (L.) Link. superfine powder 1000; Ginseng submicron powder 1000; The Radix Astragali 2000; Rhizoma Polygonati 2000; Soybean protein peptide 1000; Taurine 1000; Vitamin C 200.
4. according to the preparation method of compound Chinese caterpillar fungus oral formulations described described in any one in claim 1-3, it is characterized in that comprising following processing step:
The preparation of A, Cordyceps superfine powder, Cordyceps militaris (L.) Link. superfine powder, ginseng submicron powder: select after Cordyceps, Cordyceps militaris (L.) Link., the clean system of Radix Ginseng, in 40-50 ℃ of oven drying at low temperature, dried material is pulverized and made superfine powder with super micron mill;
The preparation of B, the Radix Astragali, Rhizoma Polygonati extract xeraphium: the Radix Astragali, Rhizoma Polygonati decoction pieces are extracted 1-3 time with purified water hot reflux, each 1-3 hour, filtration merging filtrate sieves, and while being evaporated to 60 ℃, the relative density of concentrated solution is 1.05-1.08, and spraying is dried to obtain extract xeraphium;
C, soybean protein peptide, taurine and vitamin C powder are mixed in proportion after, after being mixed with the superfine powder of preparing in steps A, B and extract xeraphium and adjuvant, make oral formulations.
5. the preparation method of compound Chinese caterpillar fungus oral formulations according to claim 4, is characterized in that in described steps A, grinding time is 5-10 minute.
6. the preparation method of compound Chinese caterpillar fungus oral formulations according to claim 4, it is characterized in that sieving in described step B is 300 mesh sieves, spray-dired condition is inlet temperature 150-190 ℃, leaving air temp 80-100 ℃, relatively pressure-10～-40Pa.
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| CN104585733A (en) * | 2014-12-31 | 2015-05-06 | 台州康晶生物科技有限公司 | Cordyceps sinensis oral tablet and preparation method thereof |
| CN104605334A (en) * | 2014-12-31 | 2015-05-13 | 浙江理工大学 | Cordyceps sinensis oral tablet and preparation method thereof |
| CN105288578A (en) * | 2015-10-20 | 2016-02-03 | 宁波君瑞生物科技有限公司 | Preparation with fatigue relieving function |
| CN105685960A (en) * | 2016-02-16 | 2016-06-22 | 江苏隆力奇生物科技股份有限公司 | Composition with refreshing and anti-fatigue effects, method for preparing composition and application thereof |
| CN105998731A (en) * | 2016-06-01 | 2016-10-12 | 谢晓亮 | Cordyceps sinensis superfine powder capsule for assisting over recovery of middle-distance race runners and application thereof |
| CN106083990A (en) * | 2016-06-02 | 2016-11-09 | 安徽新泰药业有限公司 | A kind of sealwort peptide extracting method and sealwort complex peptides powder |
| CN107432911A (en) * | 2017-08-11 | 2017-12-05 | 程炽坤 | A kind of ginseng lozenge of health kidney tonifying and preparation method thereof |
| CN112617196A (en) * | 2020-11-27 | 2021-04-09 | 成都藏源高能生物科技有限公司 | Food, health-care product or pharmaceutical composition for resisting anoxia and fatigue and preparation method and application thereof |
| CN114343173A (en) * | 2021-12-01 | 2022-04-15 | 诺倍康(东莞)科技有限公司 | Composition and preparation method and application thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585733A (en) * | 2014-12-31 | 2015-05-06 | 台州康晶生物科技有限公司 | Cordyceps sinensis oral tablet and preparation method thereof |
| CN104605334A (en) * | 2014-12-31 | 2015-05-13 | 浙江理工大学 | Cordyceps sinensis oral tablet and preparation method thereof |
| CN104585733B (en) * | 2014-12-31 | 2016-08-24 | 台州康晶生物科技有限公司 | Cordyceps oral tablet and preparation method thereof |
| CN105288578A (en) * | 2015-10-20 | 2016-02-03 | 宁波君瑞生物科技有限公司 | Preparation with fatigue relieving function |
| CN105685960A (en) * | 2016-02-16 | 2016-06-22 | 江苏隆力奇生物科技股份有限公司 | Composition with refreshing and anti-fatigue effects, method for preparing composition and application thereof |
| CN105998731A (en) * | 2016-06-01 | 2016-10-12 | 谢晓亮 | Cordyceps sinensis superfine powder capsule for assisting over recovery of middle-distance race runners and application thereof |
| CN105998731B (en) * | 2016-06-01 | 2019-11-15 | 河北省农林科学院经济作物研究所 | A kind of auxiliary realizes the cordyceps sinensis ultra micro powder capsule of middle-distance runner's overrecovery |
| CN106083990A (en) * | 2016-06-02 | 2016-11-09 | 安徽新泰药业有限公司 | A kind of sealwort peptide extracting method and sealwort complex peptides powder |
| CN107432911A (en) * | 2017-08-11 | 2017-12-05 | 程炽坤 | A kind of ginseng lozenge of health kidney tonifying and preparation method thereof |
| CN107432911B (en) * | 2017-08-11 | 2020-06-02 | 广州贵仕生物科技有限公司 | Ginseng buccal tablet for preserving health and tonifying kidney and preparation method thereof |
| CN112617196A (en) * | 2020-11-27 | 2021-04-09 | 成都藏源高能生物科技有限公司 | Food, health-care product or pharmaceutical composition for resisting anoxia and fatigue and preparation method and application thereof |
| CN114343173A (en) * | 2021-12-01 | 2022-04-15 | 诺倍康(东莞)科技有限公司 | Composition and preparation method and application thereof |
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Application publication date: 20141119 |
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