CN104147113A - Preparation method of salvia miltiorrhiza - Google Patents
Preparation method of salvia miltiorrhiza Download PDFInfo
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- CN104147113A CN104147113A CN201410418567.0A CN201410418567A CN104147113A CN 104147113 A CN104147113 A CN 104147113A CN 201410418567 A CN201410418567 A CN 201410418567A CN 104147113 A CN104147113 A CN 104147113A
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- radix salviae
- salviae miltiorrhizae
- dry
- preparation
- freezing
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Abstract
The invention relates to a preparation method of salvia miltiorrhiza. The method includes following steps: freezing, covering in stacks and drying. Prepared salvia miltiorrhiza is high in contents of salvianolic acid B and tanshinone II A.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of preparation method of Radix Salviae Miltiorrhizae, belongs to medical technical field.
Background technology
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae, has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and the effects such as relieving restlessness that clear away heart-fire, are usually used in obstruction of qi in the chest and cardialgia, dysphoria and insomnia, menoxenia, the skin infection disease such as swell and ache.The active component of Radix Salviae Miltiorrhizae mainly comprises take salvianolic acid B as main liposoluble ingredient, as protocatechuic acid, protocatechualdehyde, danshensu, caffeic acid, alkannic acid, rosmarinic acid, salvianolic acid A, salvianolic acid B and salvianolic acid C etc., with take tanshinone IIA as main tanshinone component, as cryptotanshinone, dihydrotanshinone Ⅰ, tanshinone Ⅰ, Tanshinone II etc.
Summary of the invention
The preparation method that the object of this invention is to provide a kind of Radix Salviae Miltiorrhizae.Radix Salviae Miltiorrhizae main active salvianolic acid B, the tanshinone IIA content of preparation are high.And then the vexed rear lyophilizing Radix Salviae Miltiorrhizae good effect of known heap.
The object of the present invention is achieved like this:
A preparation method for Radix Salviae Miltiorrhizae, prepares by following steps: freezing → to pile vexed → dry.
The preparation method of a kind of Radix Salviae Miltiorrhizae of the present invention, freezing is to be refrigerated to-5 ℃ with down to freezing.
The preparation method of a kind of Radix Salviae Miltiorrhizae of the present invention, piling vexed is the vexed 2-6 days of heap.
So far completed the present invention.
The present invention prepares Radix Salviae Miltiorrhizae main active salvianolic acid B, tanshinone IIA content is high, and then known, is used for the treatment of obstruction of qi in the chest and cardialgia, dysphoria and insomnia, and menoxenia, the skin infection symptom clinical efficacy such as swell and ache is good.
Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.
One, different dry drying method salvianolic acid B of Radix Salviae Miltiorrhizae, Tanshinone II
acontent comparative test
1, processing method:
The fresh salvia miltiorrhiza root of being gathered in same plot simultaneously, process by the following method respectively:
1) fresh Radix Salviae Miltiorrhizae: fresh salvia miltiorrhiza root soil buries, plastic bag sealing moisturizing;
2) dry Radix Salviae Miltiorrhizae: fresh red sage root is put to shady and cool ventilation place and dry;
3) dry Radix Salviae Miltiorrhizae: fresh red sage root is directly put under daylight and dried;
4) dry Radix Salviae Miltiorrhizae: fresh red sage root is put at 60 ℃ of temperature and dried;
5) the vexed Radix Salviae Miltiorrhizae that dries of freezing heap: by fresh red sage root heap, be refrigerated to-5 ℃ to freezing, pile vexed 3 days, dry;
6) lyophilizing Radix Salviae Miltiorrhizae: get the fresh Radix Salviae Miltiorrhizae newly digging out, in value freeze dryer, solidification point is controlled at-30 ℃, reaches and controls after temperature, is evacuated to below drying chamber pressure 50Pa, and then heating promotes distillation; The temperature of distillation is controlled at below 40 ℃; Resolution temperature is controlled at below 45 ℃, to dry;
2, salvianolic acid B, Tanshinone II
aassay: measure according to method under 2010 editions (one) Radix Salviae Miltiorrhizae items of Chinese Pharmacopoeia.Result: in dry product, Tanshinone II
ameasurement result is in Table 1, and salvianolic acid B measurement result is in Table 2.
Table 1 fresh salvia miltiorrhiza and different dry drying method Tanshinone II
acontent (%)
| Medical material | Fresh | Dry | Dry | Dry | Freezing heap is vexed to be dried | Lyophilizing |
| Content | 0.08 | 0.25 | 0.19 | 0.11 | 0.37 | 0.08 |
The red phenol decoction pieces acid of table 2 fresh salvia miltiorrhiza and different dry drying method Radix Salviae Miltiorrhizae B content (%)
| Medical material | Fresh | Dry in the shade | Dry | Dry | Freezing heap is vexed to be dried | Lyophilizing |
| Content | 0.73 | 4.21 | 3.95 | 2.98 | 6.42 | 1.06 |
Salvianolic acid B, Tanshinone II
ait is the main active of Radix Salviae Miltiorrhizae.Comparative result is known, vexed salvianolic acid B of Radix Salviae Miltiorrhizae, the Tanshinone II that dries Radix Salviae Miltiorrhizae of freezing heap
acontent is the highest.
The specific embodiment
embodiment 1
Get the fresh Radix Salviae Miltiorrhizae newly digging out, be refrigerated to-10 ℃ to freezing, pile vexed 2 days, dry.
embodiment 2
Get the fresh Radix Salviae Miltiorrhizae newly digging out, be refrigerated to-15 ℃ to freezing, pile vexed 4 days, dry.
embodiment 3
Get the fresh Radix Salviae Miltiorrhizae newly digging out, be refrigerated to-20 ℃ to freezing, pile lyophilizing vexed 6 days.
embodiment 4
Get the fresh Radix Salviae Miltiorrhizae newly digging out, be refrigerated to-30 ℃ to freezing, pile 60 ℃ of oven dry vexed 3 days.
embodiment 5
Get the fresh Radix Salviae Miltiorrhizae newly digging out, be refrigerated to-25 ℃ to freezing, pile microwave drying vexed 5 days.
Claims (3)
1. a preparation method for Radix Salviae Miltiorrhizae, prepares by following steps: freezing → to pile vexed → dry.
2. according to the preparation method of a kind of Radix Salviae Miltiorrhizae of claim 1, freezing is to be refrigerated to-5 ℃ with down to freezing.
3. according to the preparation method of a kind of Radix Salviae Miltiorrhizae of claim 1, piling vexed is the vexed 2-6 days of heap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418567.0A CN104147113A (en) | 2014-08-25 | 2014-08-25 | Preparation method of salvia miltiorrhiza |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418567.0A CN104147113A (en) | 2014-08-25 | 2014-08-25 | Preparation method of salvia miltiorrhiza |
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| Publication Number | Publication Date |
|---|---|
| CN104147113A true CN104147113A (en) | 2014-11-19 |
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|---|---|---|---|
| CN201410418567.0A Pending CN104147113A (en) | 2014-08-25 | 2014-08-25 | Preparation method of salvia miltiorrhiza |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2685684A1 (en) * | 2007-04-29 | 2008-11-13 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd. | Use of a botanical composition in preparing pharmaceutical preparation for treatment of cirrhotic portal hypertension |
| CN103610745A (en) * | 2013-09-14 | 2014-03-05 | 四川天然生中药饮片有限公司 | Sweating processing method for traditional Chinese medicine salvia miltiorrhiza high-quality decoction pieces |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
-
2014
- 2014-08-25 CN CN201410418567.0A patent/CN104147113A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2685684A1 (en) * | 2007-04-29 | 2008-11-13 | Shanghai Sundise Chinese Medicine Technology Development Co., Ltd. | Use of a botanical composition in preparing pharmaceutical preparation for treatment of cirrhotic portal hypertension |
| CN103610745A (en) * | 2013-09-14 | 2014-03-05 | 四川天然生中药饮片有限公司 | Sweating processing method for traditional Chinese medicine salvia miltiorrhiza high-quality decoction pieces |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
Non-Patent Citations (2)
| Title |
|---|
| 唐晓清等: "丹参采收后不同干燥法对丹参酮ⅡA和丹参素的影响", 《中草药》 * |
| 龙全江: "《中药材加工学》", 31 January 2006, 中国中医药出版社 * |
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Application publication date: 20141119 |