CN104147046B - A kind of for treating spray injuring infection and preparation method thereof outside domestic animal - Google Patents
A kind of for treating spray injuring infection and preparation method thereof outside domestic animal Download PDFInfo
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- CN104147046B CN104147046B CN201410382692.0A CN201410382692A CN104147046B CN 104147046 B CN104147046 B CN 104147046B CN 201410382692 A CN201410382692 A CN 201410382692A CN 104147046 B CN104147046 B CN 104147046B
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- China
- Prior art keywords
- spray
- phosphate buffer
- infection
- domestic animal
- injuring
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- 239000007921 spray Substances 0.000 title claims abstract description 32
- 201000009910 diseases by infectious agent Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000008363 phosphate buffer Substances 0.000 claims abstract description 20
- SQGYOTSLMSWVJD-UHFFFAOYSA-N Silver nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 18
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002721 Mafenide Acetate Drugs 0.000 claims abstract description 10
- UILOTUUZKGTYFQ-UHFFFAOYSA-N acetic acid;4-(aminomethyl)benzenesulfonamide Chemical compound CC(O)=O.NCC1=CC=C(S(N)(=O)=O)C=C1 UILOTUUZKGTYFQ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960002163 hydrogen peroxide Drugs 0.000 claims abstract description 10
- HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960001309 Procaine hydrochloride Drugs 0.000 claims abstract description 9
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 9
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 8
- 238000004090 dissolution Methods 0.000 claims description 6
- 239000006166 lysate Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- MFDFERRIHVXMIY-UHFFFAOYSA-N Procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-L phosphate Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000000844 anti-bacterial Effects 0.000 abstract description 4
- 230000003110 anti-inflammatory Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000035876 healing Effects 0.000 abstract description 3
- 229960001516 Silver Nitrate Drugs 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 description 3
- 230000001340 slower Effects 0.000 description 3
- 230000001225 therapeutic Effects 0.000 description 3
- 210000000003 Hoof Anatomy 0.000 description 2
- 229940035535 Iodophors Drugs 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000003203 everyday Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 206010007134 Candida infection Diseases 0.000 description 1
- 210000003414 Extremities Anatomy 0.000 description 1
- 206010022114 Injury Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 206010027699 Skin injury Diseases 0.000 description 1
- 241001493546 Suina Species 0.000 description 1
- 229940098465 Tincture Drugs 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 230000004678 mucosal integrity Effects 0.000 description 1
- XRRQZKOZJFDXON-UHFFFAOYSA-N nitric acid;silver Chemical compound [Ag].O[N+]([O-])=O XRRQZKOZJFDXON-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Abstract
The present invention relates to a kind of for treating spray injuring infection and preparation method thereof outside domestic animal, belong to technical field of animal remedy preparation, it is characterised in that be made up of mafenide acetate, silver nitrate, procaine hydrochloride, phosphate buffer, 30% hydrogenperoxide steam generator, propylene glycol；In the spray of 100ml, the content of each component is: mafenide acetate: 5g-15g；Silver nitrate: 0.3g-0.6g；Procaine hydrochloride: 1g-3g；Phosphate buffer: 60-75ml；30% hydrogenperoxide steam generator: 10ml-20ml；Propylene glycol: 4ml-8ml；Phosphate buffer is made up of disodium hydrogen phosphate, sodium dihydrogen phosphate and distilled water；The present invention for treating the spray injuring infection outside domestic animal; have antibacterial, antiinflammatory, restrain, the effect of the wound dirt that eases pain, removes; wound can be promoted to accelerate healing; medication is few, short treating period, cure rate are high, has that production cost is low, preparation method simple, it is safe and simple to use, be suitable for large-scale industrial and produces, good in economic efficiency feature.
Description
Technical field:
The present invention relates to a kind of for treating spray injuring infection and preparation method thereof outside domestic animal, belong to veterinary drug and prepare skill
Art field.
Background technology:
In domestic animal feeding process, due to mechanical factors, such as bump rail, mutually fight etc. and to cause domestic animal common outside
Section's disease, if skin or mucosal integrity are by destruction, soft tissue open injury, or artiodactyl domestic animal thrush etc.；As
Fruit treatment is not in time or the improper meeting of Therapeutic Method causes and infects deterioration further, prolonged do not heals；In order to prevent wound infection and
Secondary infection, maintains the production performance that domestic animal is good, needs to treat the wound of domestic animal in time.
In the treatment operating process of veterinary, owing to the clinical veterinary drug for the treatment of domestic animal wound is mainly powder (powder), molten
Liquid and tincture, need during operation to be applied in by hand on the wound of domestic animal, using method inconvenience, has a strong impact on the work of veterinary personnel
Make efficiency.
The present invention for treating the spray injuring infection outside domestic animal, directly the effective ingredient of medicine is sprayed on domestic animal
Wound surface, there is antibacterial, antiinflammatory, restrain, ease pain, sterilize, remove the effects such as wound dirt, using method is easy, it is possible to
Promote wound more quickly-healing.
Summary of the invention:
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide one and injure infection outside domestic animal for treating
Spray and preparation method thereof, have antibacterial, antiinflammatory, restrain, the effect of the wound dirt that eases pain, removes, it is possible to promote wound
Accelerating healing, medication is few, short treating period, cure rate are high, has that production cost is low, preparation method simple, it is safe and simple to use, is suitable for
Large-scale industrial produces, good in economic efficiency feature.
The present invention is to realize above-mentioned purpose by following technical solution.
Provided by the present invention a kind of for treating the spray injuring infection outside domestic animal, by mafenide acetate, nitric acid
Silver, procaine hydrochloride, phosphate buffer, 30% hydrogenperoxide steam generator, propylene glycol form；
In the spray of 100ml, the content of each component is:
Mafenide acetate: 5g-15g；
Silver nitrate: 0.3g-0.6g；
Procaine hydrochloride: 1g-3g；
Phosphate buffer: 60ml-75ml；
30% hydrogenperoxide steam generator: 10ml-20ml；
Propylene glycol: 4ml-8ml；
Described phosphate buffer is made up of disodium hydrogen phosphate, sodium dihydrogen phosphate and distilled water, and compound method is:
100ml distilled water adds disodium hydrogen phosphate 0.894g-2.386g, sodium dihydrogen phosphate 0.384g-1.644g prepared；
Under room temperature, the pH value of phosphate buffer is: 6.5-7.5, and concentration is: 0.2M.
A kind of preparation method for treating the spray injuring infection outside domestic animal provided by the present invention, including walking as follows
Rapid:
(1) weigh mafenide acetate 5g-15g, silver nitrate 0.3g-0.6g, procaine hydrochloride 1 g-3g, add
In the phosphate buffer of 60ml-75ml, it is completely dissolved, obtains mixed once lysate；
(2) measure 30% hydrogenperoxide steam generator 10ml-20ml, propylene glycol 4ml-8ml, join mixed once lysate
In mix completely, obtain secondary mixed dissolution liquid；
(3) in secondary mixed dissolution liquid, add phosphate buffer, be settled to 100ml, i.e. prepare for treating house
The outer spray injuring infection of poultry.
The present invention has the advantages that compared with prior art
Of the present invention for treating the spray injuring infection outside domestic animal, have antibacterial, antiinflammatory, restrain, ease pain, clear
Effect except wound dirt, it is possible to promoting wound to accelerate healing, medication is few, short treating period, cure rate are high, have production cost low,
Preparation method is simple, it is safe and simple to use, be suitable for large-scale industrial produces, good in economic efficiency feature.
Detailed description of the invention:
Below in conjunction with specific embodiment, the invention will be further described:
Embodiment 1
A kind of for treating the spray injuring infection outside domestic animal, in the spray preparing 100ml, the content of each component
For:
Mafenide acetate: 10g；
Silver nitrate: 0.4g；
Procaine hydrochloride: 2g；
Phosphate buffer: 70.6ml；
30% hydrogenperoxide steam generator: 12ml；
Propylene glycol: 5ml.
Preparation method comprises the following steps:
(1) weigh disodium hydrogen phosphate 1.732g, sodium dihydrogen phosphate 0.936 g, be dissolved in 100ml distilled water, i.e. prepare
Become phosphate buffer；Under room temperature, the pH value of phosphate buffer is 7.0, and concentration is: 0.2M.
(2) by the mafenide acetate weighed, silver nitrate, procaine hydrochloride, the phosphate-buffered of 60ml is joined
In liquid, it is completely dissolved, obtains mixed once lysate；
(3) by 30% hydrogenperoxide steam generator measured, propylene glycol, join in mixed once lysate and mix completely,
Secondary mixed dissolution liquid；
(4) in secondary mixed dissolution liquid, add phosphate buffer, be settled to 100ml, i.e. prepare for treating house
The outer spray injuring infection of poultry.
Embodiment 2
Application examples:
(1) choose a Large-scale pig farm, injure cases of infection 47, wherein because piglet docking, one-tenth pig scratch etc. are outer
Matched group 20, test group 27.
Matched group employing is smeared iodophors method and is treated；Test group uses the spray of the present invention to treat, test
During group treatment, at distance 5-8cm, spray is injured at infection outside；Degree according to injuring outward infection can be fitted
Needed for adjusting, spray number of times, moistening newly create；Infect wound to increase and spray number of times, until making wound surface clean.
Test group and matched group are all treated twice every day, observe therapeutic effect after 5 days, and result is as follows:
Matched group cures 9, and symptom slows down 8, and the cure rate treated 5 days is 45%, and effective percentage is 85%；
Test group cures 25, and effective 2, the cure rate treated 5 days is 92.6%, and effective percentage is 100%；Relative to right
According to group, using the spray cure rate of the present invention to improve 47.6%, effective percentage improves 15%.
(2) choose a large-scale cattle farm, because of fence scratch, mutually fight skin injury and milch cow limb hoof festers (hoof
Sick) etc. outer injure cases of infection 34 cow head, wherein matched group 15, test group 19.
Matched group employing is smeared iodophors method and is treated；Test group uses the spray of the present invention to treat, test
During group treatment, at distance 5-8cm, spray is injured at infection outside；Degree according to injuring outward infection can be fitted
Needed for adjusting, spray number of times, moistening newly create；Infect wound to increase and spray number of times, until making wound surface clean.
Test group and matched group are all treated twice every day, observe therapeutic effect after 5 days, and result is as follows:
Matched group cures 8, and symptom slows down 6, and the cure rate treated 5 days is 53.3%, and effective percentage is 93.3%；
Test group cures 13, and symptom slows down 6, and the cure rate treated 5 days is 68.4%, and effective percentage is 100%, relatively
In matched group, using the spray cure rate of the present invention to improve 15.1%, effective percentage improves 6.7%.
Above-described embodiment result shows, the spray of the present invention is obvious for the therapeutic effect injuring infection outside domestic animal, has
Efficiency reaches 100%, and cure rate is greatly improved.
Claims (3)
1. one kind is used for treating the spray injuring infection outside domestic animal, it is characterised in that by mafenide acetate, silver nitrate, hydrochloric acid
Procaine, phosphate buffer, 30% hydrogenperoxide steam generator, propylene glycol form；
In the spray of 100m1, the content of each component is:
Mafenide acetate: 5g-15g；
Silver nitrate: 0.3g-0.6g；
Procaine hydrochloride: 1g-3g；
Phosphate buffer: 60m1-75m1；
30% hydrogenperoxide steam generator: l0ml-20m1；
Propylene glycol: 4m1-8m1；
Described phosphate buffer is made up of disodium hydrogen phosphate, sodium dihydrogen phosphate and distilled water.
A kind of preparation method for treating the spray injuring infection outside domestic animal, its feature exists
In comprising the steps:
(1) weigh mafenide acetate 5g-15g, silver nitrate 0.3g-0.6g, procaine hydrochloride 1g-3g, join 60m1-
In the phosphate buffer of 75m1, it is completely dissolved, obtains mixed once lysate；
(2) measure 30% hydrogenperoxide steam generator l0ml-20m1, propylene glycol 4m1-8m1, join in mixed once lysate complete
Mixing, obtains secondary mixed dissolution liquid；
(3) in secondary mixed dissolution liquid, add phosphate buffer, be settled to 100m1, i.e. prepare for treating outside domestic animal
Injure the spray of infection.
The most according to claim 1 a kind of for treating the spray injuring infection outside domestic animal, it is characterised in that described
The compound method of phosphate buffer is: add disodium hydrogen phosphate 0.894g-2.386g, biphosphate in 100m1 distilled water
Sodium 0.384g-1.644g has prepared；Under room temperature, the pH value of phosphate buffer is: 6.5-7.5, and concentration is: 0.2M.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410382692.0A CN104147046B (en) | 2014-08-06 | A kind of for treating spray injuring infection and preparation method thereof outside domestic animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410382692.0A CN104147046B (en) | 2014-08-06 | A kind of for treating spray injuring infection and preparation method thereof outside domestic animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104147046A CN104147046A (en) | 2014-11-19 |
| CN104147046B true CN104147046B (en) | 2017-01-04 |
Family
ID=
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0423695A2 (en) * | 1989-10-19 | 1991-04-24 | Sterling Drug Inc. | Aerosol composition for topical medicament |
| CN1301490A (en) * | 1999-12-24 | 2001-07-04 | 董志建 | Sterilizing and disinfecting agent and its preparing method |
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0423695A2 (en) * | 1989-10-19 | 1991-04-24 | Sterling Drug Inc. | Aerosol composition for topical medicament |
| CN1301490A (en) * | 1999-12-24 | 2001-07-04 | 董志建 | Sterilizing and disinfecting agent and its preparing method |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170104 Termination date: 20180806 |