CN104127643A

CN104127643A - Medicament for treatment of cerebral apoplexy and preparation method thereof

Info

Publication number: CN104127643A
Application number: CN201410344954.4A
Authority: CN
Inventors: 刘远杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-07-21
Filing date: 2014-07-21
Publication date: 2014-11-05

Abstract

The invention discloses a medicament for the treatment of cerebral apoplexy. The medicament includinges, by weight, 5-10 parts of Mallotus barbatus, 6-10 parts of radix sileris, 5-10 parts of Pholidota cantonensis Rolfe, 15-20 parts of prepared rhizome of rehmannia, 15-20 parts of Eucommia ulmoides, 5-10 parts of saffron, 5-8 parts of Cordyceps sinensis, 3-7 parts of pangolin, 3-7 parts of dried Agkistrodon halys, 3-8 parts of dried centipede, 3-5 parts of dries King Cobra, 2-5 parts of dried Bungarus multicinctus, 15-20 parts of Paris polyphylla, 11-15 parts of leech, 4-7 parts of wood frog oviduct, 10-15 parts of eucommia bark, 15-20 parts of rhubarb, 15-20 parts of pseudo-ginseng, 5-10 parts of sea cucumber, 3-5 parts of sea urchins, 3-5 parts of Hydrophis cyanocinctus, and 15-30 parts of hawthorn. The invention has the outstanding advantage that the medicament can achieve suppression and treatment effect in the initial stage of cerebral apoplexy, and has no side effects.

Description

A kind of medicine for the treatment of apoplexy and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicinal preparation method, relate in particular to a kind of Chinese medicinal preparation method for the treatment of apoplexy, belong to pharmaceutical formulation preparation field.

Background technology

Apoplexy is the commonly encountered diseases of middle-aged and elderly people, its sickness rate is to rise appreciably with advancing age on the whole, but in recent years, the right side of fifty crowd sickness rate also has the trend of increase, effect a radical cure this disease of apoplexy more difficult, these several years recently, a lot of about the Chinese medicine and western medicine for the treatment of apoplexy in the world, but the basic feature of this class medicine is: after apoplexy forms, just start to take the obvious like this best opportunity of missing treatment.And paralytic, if apoplexy, state of an illness aggravation and even dead in the section of the there will be time, and later stage patient, Drug therapy substantially effect is not very large.Therefore, need to when the state of an illness goes out to show an inkling, suit the remedy to the case, but seldom have in the market the medicine of applicable apoplexy previous tretament.

Summary of the invention

Technical problem to be solved by this invention is that a kind of Chinese medicine that can suppress well apoplexy disease and have no side effect at the ill initial stage of apoplexy is provided.

For achieving the above object, technical scheme of the present invention is such: a kind of medicine for the treatment of apoplexy, and its Chinese medicine according to mass fraction comprises 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, 3-5 Ophiophagus hannan (Cantor) is dry, 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi.

Treat a preparation method for the medicine of apoplexy, according to treatment umber, get Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, and 3-5 Ophiophagus hannan (Cantor) is dry, 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Described mass fraction Chinese traditional medicine leech, Squama Manis, Agkistrodon halys are dry, Chinese forest frog, Ophiophagus hannan (Cantor) is dry, Agkistrodon is dry, pulverizer is crossed 140 orders after pulverizing for Stichopus japonicus, Hemicentrotus seu Strongylocentrotus, sea snake, all the other described medical materials decoct with water three times, merge extractive liquid,, after filtering, filtrate is concentrated, exhale and be dried and pulverize with affiliated medicated powder, incapsulating.

The present invention has also offered the preparation method of the medicine of another kind for the treatment of apoplexy, gets Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae, 5-10 rock pearl according to treatment umber, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, and 3-5 Ophiophagus hannan (Cantor) is dry, 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Above-mentioned medical material is shone after dry blending, put into a vial, then in vial, pour brewing grains white spirit into not having mixing medical material, finally envelope bottle is after 1 year, and taking liquid is considered every day and drunk.

Adopt after above-mentioned fabrication techniques method, the invention has the advantages that, use this product can obviously reduce cerebrovascular resistance, its action intensity is strong and possess endurance, this product is expansion of cerebral vascular and extremity vascular obviously, improve cerebral circulation and cycle of limbs, this medicine has remarkable inhibitory action to blood stasis rat model thrombosis.And because the present invention is pure Chinese medicine, therefore without any side effects.

The specific embodiment

Below the present invention is described in more detail.

Embodiment mono-: a kind of medicine for the treatment of apoplexy, comprises 5-10 seeds of a tung oil tree root according to the Chinese medicine of mass fraction, 6-10 Radix Saposhnikoviae, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, and 3-5 Ophiophagus hannan (Cantor) is dry, 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi.

Embodiment bis-: a kind of preparation method for the treatment of the medicine of apoplexy, according to treatment umber, get Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, and 3-5 Ophiophagus hannan (Cantor) is dry, 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Described mass fraction Chinese traditional medicine leech, Squama Manis, Agkistrodon halys are dry, Chinese forest frog, Ophiophagus hannan (Cantor) is dry, Agkistrodon is dry, pulverizer is crossed 140 orders after pulverizing for Stichopus japonicus, Hemicentrotus seu Strongylocentrotus, sea snake, all the other described medical materials decoct with water three times, merge extractive liquid,, after filtering, filtrate is concentrated, exhale and be dried and pulverize with affiliated medicated powder, incapsulating.

Embodiment tri-: the present invention has also offered the preparation method of the medicine of another kind for the treatment of apoplexy, get Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae according to treatment umber, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, 3-8 Scolopendra is dry, and 3-5 Ophiophagus hannan (Cantor) is dry, and 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Above-mentioned medical material is shone after dry blending, put into a vial, then in vial, pour brewing grains white spirit into not having mixing medical material, finally envelope bottle is after 1 year, and taking liquid is considered every day and drunk.

The present invention passes through capsule of the present invention, medicinal liquid of the present invention, Japan's antithrombotic pill and high molecular dextran act on respectively in white mouse, test, get 50 of white mouse, male and female half and half, fill with respectively capsule of the present invention, heavy dose of 3.6g/kg, small dose group 1.8g/kg, Japan antithrombotic pill 0.22g/kg and same volume normal saline, be administered once every day, one week of successive administration, (its herb liquid was oral, each 0.3g/mg), after last administration 40 minutes, with anesthetics, anaesthetize, by common carotid artery one external jugular vein blood vessel method, carry out thrombosis mensuration, relatively under each drug effect, the thrombosis forming on silk thread in artery blood flow kind 20 minutes.

Conclusion: wet weight of thrombus respectively: the heavy dose of group of capsule of the present invention is 11.50mg, small dose group is 11.53mg, Japan's antithrombotic pill group is 12.92mg, normal saline matched group is 14.95mg, its thrombosis suppresses to comment to be respectively 23%, 22% and 14%, shows thus, capsule of the present invention and medicinal liquid and Japanese antithrombotic pill all have the thrombotic effect of significant inhibition, but capsule of the present invention is obviously better than Japanese antithrombotic pill.

Claims

1. a medicine for the treatment of apoplexy, is characterized in that, according to the Chinese medicine of mass fraction, comprises 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, 3-5 Ophiophagus hannan (Cantor) is dry, and 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi.

2. a preparation method for the treatment of the medicine of apoplexy, is characterized in that, gets Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae according to treatment umber, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, 3-5 Ophiophagus hannan (Cantor) is dry, and 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Described mass fraction Chinese traditional medicine leech, Squama Manis, Agkistrodon halys are dry, Chinese forest frog, Ophiophagus hannan (Cantor) is dry, Agkistrodon is dry, pulverizer is crossed 140 orders after pulverizing for Stichopus japonicus, Hemicentrotus seu Strongylocentrotus, sea snake, all the other described medical materials decoct with water three times, merge extractive liquid,, after filtering, filtrate is concentrated, exhale and be dried and pulverize with affiliated medicated powder, incapsulating.

3. a preparation method for the treatment of the medicine of apoplexy, is characterized in that, gets Chinese medicine: 5-10 seeds of a tung oil tree root, 6-10 Radix Saposhnikoviae according to treatment umber, 5-10 rock pearl, 15-20 Radix Rehmanniae Preparata, the 15-20 Cortex Eucommiae, 5-10 Stigma Croci, 5-8 Cordyceps, 3-7 Squama Manis, 3-7 Agkistrodon halys is dry, and 3-8 Scolopendra is dry, 3-5 Ophiophagus hannan (Cantor) is dry, and 2-5 Agkistrodon is dry, the heavy Lou of 15-20,11-15 Hirudo, 4-7 Chinese forest frog, the 10-15 Cortex Eucommiae, 15-20 Radix Et Rhizoma Rhei, 15-20 Radix Notoginseng, 5-10 Stichopus japonicus, 3-5 Hemicentrotus seu Strongylocentrotus, 3-5 sea snake, 15-30 Fructus Crataegi; Above-mentioned medical material is shone after dry blending, put into a vial, then in vial, pour brewing grains white spirit into not having mixing medical material, finally envelope bottle is after 1 year, and taking liquid is considered every day and drunk.