CN104116924A - Traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands. The traditional Chinese medicine composition consists of the following components in parts by weight: 10-30 parts of nidus vespae, 5-27 parts of radix sophorae tonkinensis, 5-27 parts of sculellaria barbata, 5-27 parts of indian iphigenia bulb, 5-15 parts of cornu cervi degelatinatum, 5-27 parts of root of Chinese pulsatilla, 5-15 parts of radix sophorae alopecuroidis, 5-15 parts of liquorice, 5-15 parts of bupleurum, 5-12 parts of pericarpium citri reticulatae viride and 0.378-2 parts of musk. Based on the conventional syndrome treatment differentiation in traditional Chinese medicine, the formula of the traditional Chinese medicine composition disclosed by the invention combines clinical practice to carry out scientific compatibility; by virtue of repeated experiments, the best application dosage of each traditional Chinese medicine is determined; and the traditional Chinese medicine composition is especially remarkable in curative effect for treating qi-deficient stasis type and Chong-Ren ataxic type hyperplasia of mammary glands, clinically applied for over 15 years, safe and free of toxic and side effect, not only can completely radically treat hyperplasia of mammary glands, but also can achieve effect of completely regulating each organ of the body.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of Chinese medicine composition for the treatment of cyclomastopathy and its preparation method and application.
Background technology
Cyclomastopathy is the common non-inflammatory non-neoplastic disease of women, accounts for 75% of whole mastopathy, and in the women of child-bearing age, sickness rate can reach 47%, and wherein the criticality pathological changes of breast carcinoma is thought in part atypical hyperplasia.Due to the change of social work, life style, cyclomastopathy sickness rate is in recent years in rising trend.
It is how relevant with people's emotional factors that the traditional Chinese medical science thinks that women suffers from cyclomastopathy, and stagnation of QI due to depression of the liver, feelings will internal injury have material impact in the pathogenic process of cyclomastopathy.Depressed emotion usually, the stagnation of QI is not relaxed, and QI and blood week loss degree, pents up in breast venation, and newborn network meridian and vessels obstruction is obstructed and cause mastalgia; Liver-QI transversely invading the stomach, dysfunction of the spleen in transportation, the turbid interior life of expectorant, qi depression to blood stasis is held expectorant knot under the arm and is gathered for core, follows through staying poly-Ruzhong, therefore Ruzhong caking.Deficiency of the liver and kindey, Chong and Ren channel disorder is also the major reason that causes nodules of the breast.Kidney is the source of vital essence of five ZANG-organs, the raw menses of kidney qiization, and menses excites punching to appoint, and a lower uterus is appointed in punching, the upper breast that connects, the QI and blood that punching is appointed, upper behavior breast, lower behavior warp.If deficiency of kidney-QI, Chong and Ren channel disorder, QI and blood is stagnant, and the long-pending stasis of blood is gathered in breast, uterus, or mastalgia and luming, or disorderly imbalance of menses.The Chinese medicine of existing treatment cyclomastopathy has the high still low problem of cure rate of efficiency, and the prescription having is because noxious substances such as having used Cinnabaris, Realgar exists toxic and side effects.Therefore, find safe and effectively, the Chinese medicine composition that cure rate is high is extremely necessary.
Summary of the invention
In view of this, one of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cyclomastopathy, and the clinical use of said composition more than 15 years, has higher effective percentage and cure rate, safe without toxic side effect to cyclomastopathy; Another object is to provide preparation method and the application in treatment cyclomastopathy thereof of this medicine.
The present invention is achieved through the following technical solutions:
The Chinese medicine composition for the treatment of cyclomastopathy, raw material consists of the following composition by weight ratio: 10～30 parts of Nidus Vespaes, 5～27 parts of Radix Sophorae Tonkinensiss, 5～27 parts of Herba Scutellariae Barbataes, 5～27 parts of Pseudobulbus Cremastrae Seu Pleioness, 5～15 parts of Cornu Cervi Degelatinatums, 5～27 parts of the Radix Pulsatillaes, 5～15 parts of Radix Sophorae Alopecuroidiss, 5～15 parts, Radix Glycyrrhizae, 5～15 parts of Radix Bupleuri, 0.378～2 part, 5～12 parts, Pericarpium Citri Reticulatae Viride and Moschus.
Preferably, raw material consists of the following composition by weight ratio: 30 parts of Nidus Vespaes, 27 parts of Radix Sophorae Tonkinensiss, 27 parts of Herba Scutellariae Barbataes, 27 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Cornu Cervi Degelatinatums, 27 parts of the Radix Pulsatillaes, 15 parts of Radix Sophorae Alopecuroidiss, 15 parts, Radix Glycyrrhizae, 15 parts of Radix Bupleuri, 0.378 part, 12 parts, Pericarpium Citri Reticulatae Viride and Moschus.
The Chinese medicine preparation that the present invention also provides above-mentioned Chinese medicine composition to make.
Preferably, described preparation is pill.
The present invention also provides the preparation method of described Chinese medicine preparation, comprises the following steps:
(1) by Nidus Vespae, Radix Sophorae Tonkinensis, Herba Scutellariae Barbatae, Pseudobulbus Cremastrae Seu Pleiones, Cornu Cervi Degelatinatum, the Radix Pulsatillae, Radix Sophorae Alopecuroidis, Radix Glycyrrhizae, Radix Bupleuri and Pericarpium Citri Reticulatae Viride weigh by proportioning;
(2) load weighted each component in (1) step is ground into powder sterilizing after mixing;
(3) by proportioning, take Moschus, add 75% medical alcohol to grind evenly, ethanol volume is 5～10 times of Moschus weight;
(4) the Moschus mix homogeneously that powder step (2) being made and step (3) make, making pellets by mixing medical powder with honey.
Preferably, powder described in step (2) is 100 object powder.
Preferably, heated at constant temperature sterilization sterilizing 1h under 100 ℃ of conditions for sterilizing described in step (2), or by the sterilization of pressurizeing in pressure 0.8kg/cm
2, sterilizing 30min under 115 ℃ of conditions of temperature.
Preferably, mix homogeneously described in step (4) is for to grind method mix homogeneously with equivalent cover.
Preferably, described in step (4), the temperature of refined honey must not be higher than 60 ℃.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment cyclomastopathy.
Beneficial effect of the present invention is: the present invention treats as basis with traditional differential diagnosis in tcm, in conjunction with clinical practice, carry out science compatibility, and the best using dosage of each taste Chinese medicine is determined in experiment repeatedly, cyclomastopathy curative effect to deficiency of vital energy stasis type and Chong and Ren channel disorder type is particularly remarkable, cyclomastopathy thoroughly can not only be effected a radical cure, can also play the effect of each organ of across-the-board regulation human body.Its monarch drug Nidus Vespae can reducing swelling and alleviating pain, expectorant powder junction, and joining Radix Sophorae Tonkinensis, Herba Scutellariae Barbatae, Pseudobulbus Cremastrae Seu Pleiones, the Radix Pulsatillae, hard work grass can heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Adjuvant drug Cornu Cervi Degelatinatum kidney tonifying YANG invigorating, Moschus dispersing swelling and dissipating binds; Radix Bupleuri is joined Pericarpium Citri Reticulatae Viride can depressed liver-energy dispersing and QI regulating, pain relieving; Assistant is with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, heat clearing away, removing toxic substances, detumescence, depressed liver-energy dispersing and QI regulating, pain relieving, replenishing essence benefit blood.The clinical use of the present invention is more than 15 years, safe without toxic side effect, and clinical use total effective rate can reach 95%, and cure rate can reach 40.9%.
The specific embodiment
Below the preferred embodiments of the present invention are described in detail.
Embodiment 1
The Chinese medicine composition preparation for the treatment of cyclomastopathy: take respectively Nidus Vespae 100g, Radix Sophorae Tonkinensis 50g, Herba Scutellariae Barbatae 50g, Pseudobulbus Cremastrae Seu Pleiones 50g, Cornu Cervi Degelatinatum 50g, Radix Pulsatillae 50g, Radix Sophorae Alopecuroidis 50g, Radix Glycyrrhizae 50g, Radix Bupleuri 50g, Pericarpium Citri Reticulatae Viride 50g, after mixing, be ground into 100 object fine powders, after pack sealing with heated at constant temperature sterilization in the electric heating constant temperature baking oven of 100 ℃ sterilizing 1h (referring to Zhu Shengshan " research of big honeyed pills sterilizing ", CHINA JOURNAL OF CHINESE MATERIA MEDICA, in June, 1989, the 14th the 6th phase of volume).Take Moschus 0.5g, add 2.5ml, 75% medical alcohol, grinds evenly, by the equivalent cover method of grinding, mix homogeneously with the fine powder after sterilizing, refined honey with stick together, refined honey temperature is 50 ℃, makes big honeyed pills, every 6g, obtains.
Embodiment 2
The Chinese medicine composition preparation for the treatment of cyclomastopathy: weigh respectively Nidus Vespae 200g, Radix Sophorae Tonkinensis 180g, Herba Scutellariae Barbatae 180g, Pseudobulbus Cremastrae Seu Pleiones 180g, Cornu Cervi Degelatinatum 100g, Radix Pulsatillae 180g, Radix Sophorae Alopecuroidis 100g, Radix Bupleuri 100g, Pericarpium Citri Reticulatae Viride 100g, Radix Glycyrrhizae 100g, is ground into 100 object fine powders after mixing, use pressurization sterilization at pressure 0.8kg/cm
2, sterilizing 30min under 115 ℃ of conditions of temperature (referring to Zhang Hong " Chinese patent medicine finished product pressurization sterilization ", Chinese patent medicine research, the 1st phase in 1980).Take Moschus 1g, add 10ml, 75% medical alcohol, grinds evenly, by the equivalent cover method of grinding, mix homogeneously with the fine powder after sterilizing, refined honey with stick together, refined honey temperature is 60 ℃, makes big honeyed pills, every 6g, obtains.
Embodiment 3
The Chinese medicine composition preparation for the treatment of cyclomastopathy: weigh respectively Nidus Vespae 300g, Radix Sophorae Tonkinensis 270g, Herba Scutellariae Barbatae 270g, Pseudobulbus Cremastrae Seu Pleiones 270g, Cornu Cervi Degelatinatum 150g, Radix Pulsatillae 270g, Radix Sophorae Alopecuroidis 150g, Radix Bupleuri 150g, Pericarpium Citri Reticulatae Viride 120g, Radix Glycyrrhizae 150g, after mixing, be ground into 100 object fine powders, after pack sealing with heated at constant temperature sterilization in the electric heating constant temperature baking oven of 100 ℃ sterilizing 1h (referring to Zhu Shengshan " research of big honeyed pills sterilizing ", CHINA JOURNAL OF CHINESE MATERIA MEDICA, in June, 1989, the 14th the 6th phase of volume).Take Moschus 0.378g, add 2ml, 75% medical alcohol, grinds evenly, by the equivalent cover method of grinding, mix homogeneously with the fine powder after sterilizing, refined honey with stick together, refined honey temperature is 60 ℃, makes big honeyed pills, every 6g, obtains.
It should be noted that, the dosage form of Chinese medicine composition of the present invention is not limited to pill, as required, can also be any dosage form in pharmaceutics, such as capsule, oral liquid, tablet, powder etc., according to the needs of dosage form, can also add conventional adjuvant.
Composition quality standard
Character: the big honeyed pills that this product is black, taste is sweet, micro-hardship.
Differentiate: with Hesperidin-methanol saturated solution product solution in contrast, get the broken end of 9g compositions and immerse in 20mL methanol, through reflux, after 20 minutes, filter gained filtrate as need testing solution, by thin layer chromatography comparison of test results, differentiate.Concrete operations are: draw each 5～10 μ L of reference substance solution and need testing solution, put respectively in same and take on the silica gel g thin-layer plate that carboxymethyl cellulose sodium is adhesive, the lower floor's solution of chloroform-methanol-water (45:15:5) of take is developing solvent, after expansion, dry, put under ultra-violet lamp (365nm) and inspect.Test sample chromatograph is manifesting the fluorescence speckle of same color with the corresponding position of reference substance chromatograph.
Check: meet relevant every regulation under 2005 editions one of Chinese Pharmacopoeia (appendix I A) pill item:
1, outward appearance: rounding is even, color and luster is consistent, and fine and smooth moistening is neither too hard, nor too soft.
2, weight differential: press weight differential under 2005 editions one (appendix I A) pill item of < < Chinese Pharmacopoeia > > and check first method mensuration, limit test of weight variation is ± 7%.
3, moisture: press < < Chinese Pharmacopoeia > > 2005 editions (appendix IX H) and measure, contained humidity does not exceed 15%.
4, Microbe restriction test: measure asepsis growth according to 2005 editions one of < < Chinese Pharmacopoeia > > (appendix X III C) microbial limit test, detect without escherichia coli.
Clinical case efficacy analysis
Diagnostic criteria: (1) one side or bilateral breast have the single or multiple lumps that differ in size, shape is as prunus mume (sieb.) sieb.et zucc. core or nodositas, and multidigit is in outside upper quadrant, and matter is tough, and with surrounding tissue adhesion, what push away is removable, and axillary lymph knot is little; (2) pain generally shows as distending pain, twinge, alters pain, dull pain, and many and anxious state of mind and tired degree and menstrual cycle have obvious relation, and general menstruation increases the weight of before arriving, and after menstruation, alleviates; (3) other good, equal biopsy eliminating of malignant galactophore disease such as breast carcinoma, mammary gland fibroadenoma.
Diagnosis typing: (1) qi stagnation and blood stasis type: lump in breast be take twinge as main, tenderness or with dysmenorrhea, or purple coloured menses is black, amount is few, and clot is many, dark tongue quality or have petechia, tongue is few, and stringy pulse or string are puckery.(2) depressed liver and heat transmission (fire), Chong and Ren channel disorder type: breast has lump, distending pain in the chest and hypochondrium, susceptible to lose temper due to restlessness, xerostomia is dizzy, tongue fur BOHUANG, matter is red, stringy pulse or stringy and rapid pulse.
Efficacy assessment standard: (1) recovery from illness: lump, pain all disappears; (2) effective: lump disappears, pain relief, or lump dwindles more than 1/2, and pain disappears or alleviates; (3) effective: lump dwindles below 1/2, pain relief or disappearance; (4) invalid: lump and pain as usual, without significant change person.All results all confirm through ultrasound diagnosis.
Instructions of taking:
Every day 2 times, respectively once, once two balls, 30 days are 1 course for the treatment of sooner or later.
Therapeutic evaluation:
Table 1 suffers from the clinical effectiveness after Chinese medicine composition of the present invention for clothes for patients of cyclomastopathy
Model case:
Case one: Chen, 35 years old, first visit on May 27 in 2007.Patient's bilateral lump in breast companion pain more than 1 year.Often with menstrual cycle, increase the weight of, it is sick that row color ultrasound and infrared ray breast examination are diagnosed as bilateral breast hypertrophy.Once took Chinese patent medicine RUKUAIXIAO treatment 2 months, curative effect is not obvious, therefore go to a doctor.Have a medical check-up and see that the outside upper quadrant of left breast is laid one's hand on and 2cm * 3cm tuberosity, the outside upper quadrant of right breast and LOQ can touch a plurality of lesser tubercle, and quality is pliable and tough, smooth surface, and mobility is good, with skin adhesion.Diagnosis of Breast hypertrophy is sick, the stagnation of QI due to depression of the liver that belongs to the traditional Chinese medical science nodules of the breast blood stasis due to renal deficiency card of holding concurrently, the medicine of the embodiment of the present invention 3 for oral administration is after 1 course for the treatment of, pain slows down, continue to use 2 courses for the treatment of after pain sense disappear, breast checks normal thoroughly.After advise 1 menstrual cycle of after treatment again, follow up a case by regular visits to so far without recurrence.
Case two: Lee, 28 years old, examined as " mammary gland tumor " 2002 Nian Yu outer courts, and on June 14th, 2008 checks because mammary swelling pain increases the weight of to come the court, the mammary gland tumor of carrying out ahead of schedule excision, once took 1 year intermittently medicinal plan side certainly, takes altogether 90 pairs of prescriptions treatments.Have no improvement, I show right mammary gland tumor 30mm * 40mm by institute's mammary gland B ultrasonic.Menstrual cycle is still accurate, menstrual period 4～5 d, in amount, clot is few, lower abdomen is slightly swollen, distention and pain of breast before menstruation is violent, leukorrhagia increases, yellow skin.Card belongs to stagnation of QI due to depression of the liver, Chong and Ren channel disorder.Symptom belongs to therapeutic domain of the present invention, therefore take the medicine of the embodiment of the present invention 1, is clearly better 2 courses for the treatment of before medicine rear udder attachment distending pain ratio, and lump in breast obviously diminishes, invariably suitable through fore udder.During further consultation, continue to take 2 courses for the treatment of, follow up a case by regular visits to patient's chest lump so far and disappear, without significant discomfort.
Case three: Zhu, female, 34 years old, first visit on October 26 in 2008.Main suit: the conscious bilateral breast of patient portion distending pain is with lump 23d.Indagation is judged as bilateral breast portion distending pain with lump a plurality of (the maximum is 3 * 3.5cm approximately), and reckling is (1.5 * 1.5cm) approximately, and surrounding skin is slightly red, looks into Color B-Type Ultrasonic, B ultrasonic prompting bilateral breast hypertrophy.With the Drug therapy of inventive embodiments 3.December check on the 15th, bilateral breast portion is without distending pain, and lump obviously reduces.After advise and take again 1 course for the treatment of, after patient without following up a case by regular visits to record.
Case four: Wei, female, 41 years old, first visit in 2010.Left breast has just like the large tag of Semen Viciae fabae half a year, consciously progressively increase, companion's menoxenia,, medium through measuring, have clot, breast and lower abdominal distention pain when menstruation comes, lump distending pain more so, susceptible to lose temper due to restlessness, light red tongue tongue is white, stringy and rolling pulse.Control with 1 of the medicine of the embodiment of the present invention 2 rear udder attachment distending pain course for the treatment of and be clearly better than in the past.Treat after 2 menstrual cycle, lump obviously dwindles, pain relief.Consolidate and take medicine after 1 menstrual cycle, lump dissipates, and pain disappears.
Case five: Zhang, female, 32 years old, first visit on October 8 in 2009.Patient because of family's contradiction after uncomfortable in chest calming the anger, distending pain in the chest and hypochondrium, during breast and as acupuncture sample pain.Patient's readme once checked and suffered from cyclomastopathy before 1 year, takes Chinese patent medicine recover in outer court, existing outbreak repeatedly again, and disease is seen distending pain of the breast, can touch streak lump, matter is soft, mammary gland infrared scan prompting: cyclomastopathy.Card belongs to stagnation of QI due to depression of the liver.1 of the medicine medicine rear udder attachment lump course for the treatment of of taking the embodiment of the present invention 3 obviously dwindles, pain relief.Continue to take medicine after 2 months, lump dissipates, and pain disappears, and follows up a case by regular visits to without recurrence.
Case six: Zhao, female, 26 years old, December in 2007 first visit on the 8th.The nearly breast swell and pain in April of patient, the pain of touching very, initial premenstrual 10 days pain, through after naturally alleviate, closely January, through the swollen aching as needle stabbing of rear udder attachment, breast can touch lump regardless of premenstrual, matter is softer, postponed menstruation, menalgia, aversion to cold and cold limbs, complexion Guang is white.The medicine of using the embodiment of the present invention 3 for oral administration is after 2 courses for the treatment of, and pain slows down, and breast checks normal thoroughly.After 2 courses for the treatment of are used in consolidation more afterwards, pain sense disappears, sick announcement recovery from illness.
Case seven: Huang, female, 38 years old, patient suffered from cyclomastopathy more than 4 years, time heavy when light, obstinate, comes to seek medical advice out of admiration for a famous person.Patient's readme distending pain of the breast, regardless of premenstrual through after, breast can touch lump, and matter is harder, and patient comes institute not do ultrasound diagnosis, directly allow the doctor be that it opens the hospital preparation in the present invention, by taking readme symptom after 1 month the course for the treatment of, obviously alleviate, check and touch lump deliquescing, then take 1 course for the treatment of, patient's chest lump disappears, without significant discomfort.Follow up a case by regular visits to so far without recurrence.
Case eight: Lee, female, 43 years old, first visit time: on July 17th, 2010, nonlocal patient.Main suit: two breasts are distending pain 3 years repeatedly, aggravates 1 month, and mastalgia and menstrual cycle are irrelevant.History of present illness: the two breasts of patient are distending pain repeatedly, once, at many hospital therapies, takes RUHE SANJIE PIAN, and PINGXIAO JIA0NANG etc. are invalid.Nearly January distending pain of the breast more very, susceptible to lose temper due to restlessness, poor sleep, last menstrual period: April 1, fertility 1 tire, has suckling, Hypomenorrhea, colour cast is dark.Clinical examination: two laitance colors are normal, and body of gland thickens, and are dispersed in the dozens of tuberosity that differs in size, and quality is partially hard, and mobility is good, touches a tender spot obviously, and two axillary lymph knots do not touch.Auxiliary examination: mammary gland color ultrasound and breast molybdenum target x-ray are taken a picture, and are all diagnosed as cyclomastopathy.The two breasts of color ultrasound prompting are visited and 0.5-1.8cm differs in size a plurality of opaques dark area of fluid.Take 1 course for the treatment of of medicine of the embodiment of the present invention 3.Two examine: treat after 1 course for the treatment of breast deliquescing, pain relief.Menstrual blood volume increased more in the past, invariably suitable through fore udder.During further consultation, continue to take 2 courses for the treatment of.Three examine: further consultation on November 28 in 2010, mastalgia obviously alleviates, sleep improvement.Check mammary gland color ultrasound: two breasts are not visited and obvious tuberosity.Mastalgia disappears, and breast tuberosity disappears.
Case nine: Liu, female, 43 years old, on April 21st, 2007 was medical.The outer upside of the left breast of patient has one 4cm * 2cm * 1.5cm enclosed mass, and clear border is strong but pliable in texture, touch a tender spot obviously, and 9 months.Closely over the past half year, emaciated physique, vexed impatient.Card belongs to: stagnation of QI due to depression of the liver, Chong and Ren channel disorder.2 of the medicines medicine rear udder attachment lump course for the treatment of of taking the embodiment of the present invention 3 obviously diminishes, invariably suitable through fore udder.During further consultation, continue to take 2 courses for the treatment of, follow up a case by regular visits to patient's chest lump so far and disappear, without significant discomfort.
Case ten: Chen, female, unmarried, November 4 in 2008, daily inspection report claimed: cyclomastopathy.On August 21st, 2009 is to our hospital.Patient's 14 the beginning of the year tides, premenstrual distending pain of the breast, can not touch, and 1 of the medicine medicine rear udder attachment distending pain symptom course for the treatment of of taking the embodiment of the present invention 3 alleviates, and lump diminishes, invariably suitable through fore udder.Continue to take 1 course for the treatment of, follow up a case by regular visits to patient's lump so far and disappear, without significant discomfort.
Case 11: Zhao, female, 45 years old, first visit on June 7 in 2005.Mammary swelling pain, touch a tender spot and bilateral lump 5 wheat harvesting periods, once took Chinese patent medicine RUPIXIAO and 15 doses of plan sides certainly, symptom is without improvement, to our hospital, and 1 of the medicine medicine rear udder attachment distending pain course for the treatment of of taking the embodiment of the present invention 3 before alleviates, and lump in breast does not touch.
Case 12: thank certain, female, 27 years old, first visit on October 3 in 2008.Patient's distending pain of the breast premenstruum more than 2 years, preceeded menorrhea amount is few, and color is light red, abdominal pain in menstruation, breast can touch and be dispersed in a plurality of lesser tubercle, has tenderness, and the rear udder attachment distending pain of passing through fades away.Outer court's Western medicine diagnose: cyclomastopathy.Chinese medical discrimination: insufficiency of vital energy and blood, stagnation of liver-QI stasis.Once take the treatments such as Western medicine and Chinese patent medicine ease pill, failed to respond to any medical treatment medical afterwards, took the medicine rear udder attachment pain relief of the embodiment of the present invention 3, transference cure.
Case 13: Zhao, female, 38 years old, first visit on October 11 in 2009.Two breast cakings 4 years.Start less, after grow up gradually, distending pain before menstruation comes, lump hardening, through only soft.Check that two breast all have approximately 3 * 5cm size of caking, obscure boundary, pliable, still smooth without tuberosity, with surrounding tissue adhesion, what push away can be movable.Take the medicine of the embodiment of the present invention 2 after 1 course for the treatment of, distending pain alleviates, and caking deliquescing, then takes after 1 course for the treatment of, two breast cakings still, but distending pain not, after advise it to take medicine 2 courses for the treatment of, breast caking disappears, the eumenorrhea.
Case 14: Wang, female, 30 years old.October 5 calendar year 2001 is medical.Because premenstrual distending pain of the breast shows effect 2 years repeatedly, in the recent period because angry postemphasis comes to go to a doctor.Check that bilateral breast all has flat block lump, the pain of touching, clear border, the colour of skin is normal, with surrounding tissue without adhesion, lump distending pain, breast increases, and through galactophore scanning, is diagnosed as bilateral breast cyclomastopathy.Once took the medicine treatments such as infantile eczema disappears, pain slightly can be alleviated, but lump fails to disappear.Take the medicine of the embodiment of the present invention 2 after 1 course for the treatment of, bilateral distending pain of the breast obviously alleviates, lump deliquescing.Continue again to take 1 course for the treatment of, bilateral breast is especially in distending pain disappearance premenstruum, and the flat lump of the outside upper quadrant of bilateral breast disappears, and advises it to adjust smooth mood, follows up a case by regular visits to half a year, and above symptom is recurrence again.
Case 15: Zhang, female, 47 years old.Consultation time on April 24th, 2011.Main suit's premenstruum, two mammary swelling pains, can increase the weight of while feeling blue.In JIUYUE, 2008 and in January, 2011 B ultrasonic prompting: bilateral breast hypertrophy.Take the medicine of the embodiment of the present invention 3 after 1 course for the treatment of, spirit takes a turn for the better, and two mammary swellings pains are obviously alleviated, serve on 3 months after B ultrasonic prompting: bilateral breast no abnormality seen.Advise patient to keep phychology gentle, moderate exercise, low fat diet, makes regular check on, and follows up a case by regular visits to so far not recurrence.
Case 16: Liu, female, 37 years old, married, there is a female.Tell and while having a bath, touch right breast and have two little lumps of Semen Viciae fabae size, menstrual period, distending pain of the breast was obvious.Come the court medical, inspection right breast can be touched the fritter that can move that light weight softness pushes away, and points out: right side cyclomastopathy through infrared breast diagnosis instrument inspection.Once took XIAOYAO POWDER plus-minus side treatment 2 months, symptom alleviates, and lump is unchanged.The medicine of taking the embodiment of the present invention 3 is followed up a case by regular visits to patient's lump after 2 courses for the treatment of and is dwindled, distending pain transference cure.
Case 17: Liu, female, 42 years old.First visit on May 12 in 2012.Patient tells distending pain of the breast over 2 years and repeatedly shows effect, and with left breast, for very, pain and menstrual cycle are irrelevant.Once took RUPIXIAO, TAMOXIFEN PIAN, pain relief is not obvious.Previously row left breast fibroma is excised history, and menstrual cycle is normal, measures on the low side.Have a medical check-up: two breast is symmetrical, the outside upper quadrant of left breast can and an about 3cm operative scar, left breast can and streak and granular tuberosity, quality is medium, and movable good, tenderness is obvious, during the outside upper quadrant pain of left breast, lead to left hand arm, bilateral oxter is enlarged lymph node not and obviously.The medicine of taking the embodiment of the present invention 3 after 1 course for the treatment of main suit's distending pain be clearly better, left breast is even distending pain.Take after 1 course for the treatment of, two tubercula mammillares are not obvious again.
It should be noted that, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can to it, make various changes in the form and details, and not depart from the claims in the present invention book limited range.
Claims (10)
1. treat the Chinese medicine composition of cyclomastopathy, it is characterized in that, raw material consists of the following composition by weight ratio: 10～30 parts of Nidus Vespaes, 5～27 parts of Radix Sophorae Tonkinensiss, 5～27 parts of Herba Scutellariae Barbataes, 5～27 parts of Pseudobulbus Cremastrae Seu Pleioness, 5～15 parts of Cornu Cervi Degelatinatums, 5～27 parts of the Radix Pulsatillaes, 5～15 parts of Radix Sophorae Alopecuroidiss, 5～15 parts, Radix Glycyrrhizae, 5～15 parts of Radix Bupleuri, 0.378～2 part, 5～12 parts, Pericarpium Citri Reticulatae Viride and Moschus.
2. Chinese medicine composition according to claim 1, it is characterized in that, raw material consists of the following composition by weight ratio: 30 parts of Nidus Vespaes, 27 parts of Radix Sophorae Tonkinensiss, 27 parts of Herba Scutellariae Barbataes, 27 parts of Pseudobulbus Cremastrae Seu Pleioness, 15 parts of Cornu Cervi Degelatinatums, 27 parts of the Radix Pulsatillaes, 15 parts of Radix Sophorae Alopecuroidiss, 15 parts, Radix Glycyrrhizae, 15 parts of Radix Bupleuri, 0.378 part, 12 parts, Pericarpium Citri Reticulatae Viride and Moschus.
3. the Chinese medicine preparation of being made by the Chinese medicine composition described in claim 1～2 any one.
4. Chinese medicine preparation according to claim 3, is characterized in that, described preparation is pill.
5. the preparation method of Chinese medicine preparation described in claim 4, is characterized in that, comprises the following steps:
(1) by Nidus Vespae, Radix Sophorae Tonkinensis, Herba Scutellariae Barbatae, Pseudobulbus Cremastrae Seu Pleiones, Cornu Cervi Degelatinatum, the Radix Pulsatillae, Radix Sophorae Alopecuroidis, Radix Glycyrrhizae, Radix Bupleuri and Pericarpium Citri Reticulatae Viride weigh by proportioning;
(2) load weighted each component in (1) step is ground into powder sterilizing after mixing;
(3) by proportioning, take Moschus, add 75% medical alcohol to grind evenly, ethanol volume is 5～10 times of Moschus weight;
(4) the Moschus mix homogeneously that powder step (2) being made and step (3) make, making pellets by mixing medical powder with honey.
6. preparation method according to claim 5, is characterized in that, powder described in step (2) is 100 object powder.
7. preparation method according to claim 5, is characterized in that, heated at constant temperature sterilization sterilizing 1h under 100 ℃ of conditions for sterilizing described in step (2), or by the sterilization of pressurizeing in pressure 0.8kg/cm
2, sterilizing 30min under 115 ℃ of conditions of temperature.
8. preparation method according to claim 5, is characterized in that, described in step (4), mix homogeneously is for to grind method mix homogeneously with equivalent cover.
9. preparation method according to claim 5, is characterized in that, described in step (4), the temperature of refined honey must not be higher than 60 ℃.
10. the application of the Chinese medicine composition described in claim 1～2 any one in the medicine of preparation treatment cyclomastopathy.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116115702A (en) * | 2022-12-21 | 2023-05-16 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Flavored honeycomb pill composition and application thereof |
| CN116832119A (en) * | 2023-07-20 | 2023-10-03 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Application of flavored honeycomb pills in preparation of medicines for treating lymphadenitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406628A (en) * | 2008-11-21 | 2009-04-15 | 许景波 | Pills for treating breast |
| CN101549129A (en) * | 2008-04-03 | 2009-10-07 | 向朝晖 | Traditional Chinese medicine for curing breast hyperplasia and preparation process thereof |
| CN102000301A (en) * | 2010-11-17 | 2011-04-06 | 黄文珍 | Traditional Chinese medicine composite for treating mammitis and lobular hyperplasia of mammary gland and preparation method thereof |
-
2014
- 2014-08-11 CN CN201410391275.2A patent/CN104116924B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101549129A (en) * | 2008-04-03 | 2009-10-07 | 向朝晖 | Traditional Chinese medicine for curing breast hyperplasia and preparation process thereof |
| CN101406628A (en) * | 2008-11-21 | 2009-04-15 | 许景波 | Pills for treating breast |
| CN102000301A (en) * | 2010-11-17 | 2011-04-06 | 黄文珍 | Traditional Chinese medicine composite for treating mammitis and lobular hyperplasia of mammary gland and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王本余: "乳腺增生病治疗概述", 《河北中医》 * |
| 谷福根等: "蜂房丸的薄层色谱鉴别", 《中国药业》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116115702A (en) * | 2022-12-21 | 2023-05-16 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Flavored honeycomb pill composition and application thereof |
| CN116115702B (en) * | 2022-12-21 | 2024-04-26 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Flavored honeycomb pill composition and application thereof |
| CN116832119A (en) * | 2023-07-20 | 2023-10-03 | 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) | Application of flavored honeycomb pills in preparation of medicines for treating lymphadenitis |
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| CN104116924B (en) | 2018-07-06 |
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