CN104114693A - 与褐色脂肪样细胞相关的方法和组合物 - Google Patents

与褐色脂肪样细胞相关的方法和组合物 Download PDF

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Publication number
CN104114693A
CN104114693A CN201380009655.9A CN201380009655A CN104114693A CN 104114693 A CN104114693 A CN 104114693A CN 201380009655 A CN201380009655 A CN 201380009655A CN 104114693 A CN104114693 A CN 104114693A
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China
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cells
brown
protein
derived
adipocyte
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CN201380009655.9A
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English (en)
Chinese (zh)
Inventor
A.塞达
D.C.科特
C.S.布恩苏塞索
C.C.卡扎内基
S.德哈纳拉
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DePuy Products Inc
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DePuy Products Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380009655.9A 2012-02-15 2013-02-14 与褐色脂肪样细胞相关的方法和组合物 Pending CN104114693A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261599080P 2012-02-15 2012-02-15
US61/599080 2012-02-15
PCT/US2013/026170 WO2013123214A1 (en) 2012-02-15 2013-02-14 Methods and composition related to brown adipose-like cells

Publications (1)

Publication Number Publication Date
CN104114693A true CN104114693A (zh) 2014-10-22

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CN201380009655.9A Pending CN104114693A (zh) 2012-02-15 2013-02-14 与褐色脂肪样细胞相关的方法和组合物

Country Status (16)

Country Link
US (1) US20130209418A1 (https=)
EP (1) EP2814949A1 (https=)
JP (1) JP2015508654A (https=)
KR (1) KR20140133574A (https=)
CN (1) CN104114693A (https=)
AU (1) AU2013221474A1 (https=)
BR (1) BR112014020229A8 (https=)
CA (1) CA2864103A1 (https=)
HK (1) HK1205185A1 (https=)
IN (1) IN2014DN06603A (https=)
MX (1) MX2014009837A (https=)
PH (1) PH12014501796A1 (https=)
RU (1) RU2014137102A (https=)
SG (1) SG11201404763XA (https=)
WO (1) WO2013123214A1 (https=)
ZA (1) ZA201406726B (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107278161A (zh) * 2014-12-29 2017-10-20 伊西康有限责任公司 用于在激活褐色脂肪组织时抑制神经的方法和装置
CN108350423A (zh) * 2015-07-10 2018-07-31 法国血液机构 用于获得人类褐色/米色脂肪细胞的方法
CN110484566A (zh) * 2019-08-29 2019-11-22 中国人民解放军第四军医大学 一种类棕色脂肪外泌体及其工程化生产方法和应用
CN113493764A (zh) * 2021-07-27 2021-10-12 新乡医学院 一种体外诱导小鼠耳朵间充质干细胞分化为脂肪细胞的方法
CN114729312A (zh) * 2019-11-25 2022-07-08 株式会社片冈制作所 培养基用组合物
CN115433707A (zh) * 2015-12-07 2022-12-06 再生疗法有限公司 用于重新衍生不同的多能干细胞衍生的褐色脂肪细胞的方法
WO2025153091A1 (en) * 2024-01-19 2025-07-24 China Medical University Genetically engineered mesenchymal stem cells and uses thereof
US12421513B2 (en) 2013-06-05 2025-09-23 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10335437B2 (en) 2012-08-10 2019-07-02 The Trustees Of Columbia University In The City Of New York Injectable brown adipose microtissues for treatment and prevention of obesity and diabetes
AU2014253920B2 (en) * 2013-04-19 2019-07-04 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
US20210077536A1 (en) 2019-04-29 2021-03-18 Biorestorative Therapies, Inc. Non-naturally occuring three-dimensional (3d) brown adipose-derived stem cell aggregates, and methods of generating and using the same
CN114225006B (zh) * 2021-12-22 2023-10-13 南京市妇幼保健院 一种棕色脂肪细胞分泌肽在低体温疾病防治中的应用

Citations (2)

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US20110076769A1 (en) * 2009-09-30 2011-03-31 Advanced Technologies And Regenerative Medicine, Llc Mammary artery derived cells and methods of use in tissue repair and regeneration
CN102105789A (zh) * 2008-05-27 2011-06-22 奥列弗·D·博斯 人骨骼肌中的褐色脂肪细胞祖细胞

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US20100150885A1 (en) * 2005-06-01 2010-06-17 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
CN102083969A (zh) * 2008-05-06 2011-06-01 乔斯林糖尿病中心股份有限公司 诱导褐色脂肪形成的方法和组合物

Patent Citations (2)

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CN102105789A (zh) * 2008-05-27 2011-06-22 奥列弗·D·博斯 人骨骼肌中的褐色脂肪细胞祖细胞
US20110076769A1 (en) * 2009-09-30 2011-03-31 Advanced Technologies And Regenerative Medicine, Llc Mammary artery derived cells and methods of use in tissue repair and regeneration

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHANNES KLEIN 等: "Novel adipocyte lines from brown fat:a model system for the study of differentiation，energy metabolism，and insulin action", 《BIOESSAYS》, vol. 24, 31 December 2002 (2002-12-31) *
KHANH-VAN TRAN 等: "The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells", 《CELL METABOLISM》, vol. 15, no. 2, 8 February 2012 (2012-02-08) *
杨华 等: "脂肪来源细胞在缺血性心脏病中的应用", 《基础医学与临床》, vol. 30, no. 1, 31 December 2010 (2010-12-31), pages 1226 - 1229 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12421513B2 (en) 2013-06-05 2025-09-23 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species
US12492400B2 (en) 2013-06-05 2025-12-09 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species
CN107278161A (zh) * 2014-12-29 2017-10-20 伊西康有限责任公司 用于在激活褐色脂肪组织时抑制神经的方法和装置
CN108350423A (zh) * 2015-07-10 2018-07-31 法国血液机构 用于获得人类褐色/米色脂肪细胞的方法
CN115433707A (zh) * 2015-12-07 2022-12-06 再生疗法有限公司 用于重新衍生不同的多能干细胞衍生的褐色脂肪细胞的方法
US12404493B2 (en) 2015-12-07 2025-09-02 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
CN110484566A (zh) * 2019-08-29 2019-11-22 中国人民解放军第四军医大学 一种类棕色脂肪外泌体及其工程化生产方法和应用
CN114729312A (zh) * 2019-11-25 2022-07-08 株式会社片冈制作所 培养基用组合物
CN113493764A (zh) * 2021-07-27 2021-10-12 新乡医学院 一种体外诱导小鼠耳朵间充质干细胞分化为脂肪细胞的方法
CN113493764B (zh) * 2021-07-27 2023-01-24 新乡医学院 一种体外诱导小鼠耳朵间充质干细胞分化为脂肪细胞的方法
WO2025153091A1 (en) * 2024-01-19 2025-07-24 China Medical University Genetically engineered mesenchymal stem cells and uses thereof

Also Published As

Publication number Publication date
BR112014020229A8 (pt) 2017-07-11
AU2013221474A1 (en) 2014-09-25
HK1205185A1 (en) 2015-12-11
PH12014501796A1 (en) 2014-11-24
MX2014009837A (es) 2014-09-16
EP2814949A1 (en) 2014-12-24
SG11201404763XA (en) 2014-10-30
IN2014DN06603A (https=) 2015-05-22
BR112014020229A2 (https=) 2017-06-20
ZA201406726B (en) 2016-05-25
US20130209418A1 (en) 2013-08-15
WO2013123214A1 (en) 2013-08-22
JP2015508654A (ja) 2015-03-23
RU2014137102A (ru) 2016-04-10
CA2864103A1 (en) 2013-08-22
KR20140133574A (ko) 2014-11-19

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