CN104114548B - (5-氟-2-甲基-3-喹啉-2-基甲基-吲哚-1-基)-乙酸酯的制备方法 - Google Patents
(5-氟-2-甲基-3-喹啉-2-基甲基-吲哚-1-基)-乙酸酯的制备方法 Download PDFInfo
- Publication number
- CN104114548B CN104114548B CN201280066207.8A CN201280066207A CN104114548B CN 104114548 B CN104114548 B CN 104114548B CN 201280066207 A CN201280066207 A CN 201280066207A CN 104114548 B CN104114548 B CN 104114548B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- iii
- reaction
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1c(Cc2nc(cccc3)c3cc2)c2cc(F)ccc2[n]1CC(O*)=O Chemical compound Cc1c(Cc2nc(cccc3)c3cc2)c2cc(F)ccc2[n]1CC(O*)=O 0.000 description 5
- VLEINPWBVBHKOR-UHFFFAOYSA-N FCCCc1nc2ccccc2cc1 Chemical compound FCCCc1nc2ccccc2cc1 VLEINPWBVBHKOR-UHFFFAOYSA-N 0.000 description 1
- WPYJKGWLDJECQD-UHFFFAOYSA-N O=Cc1nc(cccc2)c2cc1 Chemical compound O=Cc1nc(cccc2)c2cc1 WPYJKGWLDJECQD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201121557A GB201121557D0 (en) | 2011-12-15 | 2011-12-15 | Process |
| GB1121557.1 | 2011-12-15 | ||
| PCT/GB2012/000903 WO2013088108A1 (en) | 2011-12-15 | 2012-12-14 | Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104114548A CN104114548A (zh) | 2014-10-22 |
| CN104114548B true CN104114548B (zh) | 2016-01-20 |
Family
ID=45560499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280066207.8A Expired - Fee Related CN104114548B (zh) | 2011-12-15 | 2012-12-14 | (5-氟-2-甲基-3-喹啉-2-基甲基-吲哚-1-基)-乙酸酯的制备方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9102658B2 (enExample) |
| EP (1) | EP2791129B1 (enExample) |
| JP (2) | JP6300277B2 (enExample) |
| KR (1) | KR102018929B1 (enExample) |
| CN (1) | CN104114548B (enExample) |
| AU (1) | AU2012351341B2 (enExample) |
| BR (1) | BR112014014604B1 (enExample) |
| CA (1) | CA2859281C (enExample) |
| CY (1) | CY1117087T1 (enExample) |
| DK (1) | DK2791129T3 (enExample) |
| EA (1) | EA026617B1 (enExample) |
| ES (1) | ES2557762T3 (enExample) |
| GB (1) | GB201121557D0 (enExample) |
| HR (1) | HRP20151422T1 (enExample) |
| HU (1) | HUE028257T2 (enExample) |
| IL (1) | IL233132A (enExample) |
| ME (1) | ME02348B (enExample) |
| MX (1) | MX342273B (enExample) |
| PL (1) | PL2791129T3 (enExample) |
| PT (1) | PT2791129E (enExample) |
| RS (1) | RS54523B1 (enExample) |
| SG (1) | SG11201402798RA (enExample) |
| SI (1) | SI2791129T1 (enExample) |
| SM (1) | SMT201500327B (enExample) |
| UA (1) | UA111868C2 (enExample) |
| WO (1) | WO2013088108A1 (enExample) |
| ZA (1) | ZA201404246B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201103837D0 (en) | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
| GB201121557D0 (en) * | 2011-12-15 | 2012-01-25 | Oxagen Ltd | Process |
| GB201322273D0 (en) * | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| EP3902794A1 (en) | 2018-12-27 | 2021-11-03 | Chiesi Farmaceutici S.p.A. | Process for preparing spherical agglomerates of timapiprant |
| CN111978245A (zh) * | 2020-09-15 | 2020-11-24 | 上海毕得医药科技有限公司 | 一种3-氟-2-异丁基吡啶的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101133047A (zh) * | 2005-03-01 | 2008-02-27 | 奥克萨根有限公司 | 微晶（5-氟-2-甲基-3-喹啉-2-基甲基-吲哚-1-基）乙酸 |
| CN101141956A (zh) * | 2003-10-23 | 2008-03-12 | 奥克萨根有限公司 | Crth2拮抗剂化合物在治疗中的用途 |
| CN101432264A (zh) * | 2006-03-22 | 2009-05-13 | 奥克萨根有限公司 | 具有crth2拮抗剂活性的盐 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1675826A1 (en) | 2003-10-14 | 2006-07-05 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB0505048D0 (en) | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
| US7188489B2 (en) | 2005-04-12 | 2007-03-13 | Martello Russell A | Portable air conditioner |
| EP2046740B1 (en) | 2006-07-22 | 2012-05-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
| US20110124683A1 (en) | 2007-11-13 | 2011-05-26 | Oxagen Limited | Use of CRTH2 Antagonist Compounds |
| NZ587251A (en) | 2008-01-18 | 2011-12-22 | Oxagen Ltd | Indole derivatives having CRTH2 antagonist activity |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| WO2009093026A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| US20130052190A1 (en) | 2011-02-22 | 2013-02-28 | Oxagen Limited | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions |
| GB201103837D0 (en) | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
| GB201121557D0 (en) | 2011-12-15 | 2012-01-25 | Oxagen Ltd | Process |
| WO2013088109A1 (en) | 2011-12-16 | 2013-06-20 | Oxagen Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
-
2011
- 2011-12-15 GB GB201121557A patent/GB201121557D0/en not_active Ceased
-
2012
- 2012-12-14 SG SG11201402798RA patent/SG11201402798RA/en unknown
- 2012-12-14 JP JP2014546621A patent/JP6300277B2/ja not_active Expired - Fee Related
- 2012-12-14 MX MX2014007129A patent/MX342273B/es active IP Right Grant
- 2012-12-14 WO PCT/GB2012/000903 patent/WO2013088108A1/en not_active Ceased
- 2012-12-14 DK DK12805725.4T patent/DK2791129T3/en active
- 2012-12-14 EP EP12805725.4A patent/EP2791129B1/en active Active
- 2012-12-14 EA EA201490998A patent/EA026617B1/ru unknown
- 2012-12-14 CN CN201280066207.8A patent/CN104114548B/zh not_active Expired - Fee Related
- 2012-12-14 HR HRP20151422TT patent/HRP20151422T1/hr unknown
- 2012-12-14 US US14/364,509 patent/US9102658B2/en not_active Expired - Fee Related
- 2012-12-14 HU HUE12805725A patent/HUE028257T2/en unknown
- 2012-12-14 CA CA2859281A patent/CA2859281C/en active Active
- 2012-12-14 PL PL12805725T patent/PL2791129T3/pl unknown
- 2012-12-14 ES ES12805725.4T patent/ES2557762T3/es active Active
- 2012-12-14 SI SI201230408T patent/SI2791129T1/sl unknown
- 2012-12-14 UA UAA201406835A patent/UA111868C2/uk unknown
- 2012-12-14 BR BR112014014604-7A patent/BR112014014604B1/pt not_active IP Right Cessation
- 2012-12-14 RS RS20150871A patent/RS54523B1/sr unknown
- 2012-12-14 PT PT128057254T patent/PT2791129E/pt unknown
- 2012-12-14 KR KR1020147017740A patent/KR102018929B1/ko not_active Expired - Fee Related
- 2012-12-14 AU AU2012351341A patent/AU2012351341B2/en not_active Ceased
- 2012-12-14 ME MEP-2015-218A patent/ME02348B/me unknown
-
2014
- 2014-06-09 ZA ZA2014/04246A patent/ZA201404246B/en unknown
- 2014-06-15 IL IL233132A patent/IL233132A/en active IP Right Grant
-
2015
- 2015-12-23 SM SM201500327T patent/SMT201500327B/it unknown
- 2015-12-23 CY CY20151101189T patent/CY1117087T1/el unknown
-
2017
- 2017-07-28 JP JP2017146700A patent/JP2018008985A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101141956A (zh) * | 2003-10-23 | 2008-03-12 | 奥克萨根有限公司 | Crth2拮抗剂化合物在治疗中的用途 |
| CN101133047A (zh) * | 2005-03-01 | 2008-02-27 | 奥克萨根有限公司 | 微晶（5-氟-2-甲基-3-喹啉-2-基甲基-吲哚-1-基）乙酸 |
| CN101432264A (zh) * | 2006-03-22 | 2009-05-13 | 奥克萨根有限公司 | 具有crth2拮抗剂活性的盐 |
Non-Patent Citations (1)
| Title |
|---|
| A Mild and Selective C-3 Reductive Alkylation of Indoles;Julie E.Appleton et al.;《Tetrahedron Letters》;19931231;第34卷(第9期);第1529-1532页 * |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 |