CN104114168A - 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂) - Google Patents

治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂) Download PDF

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Publication number
CN104114168A
CN104114168A CN201380009083.4A CN201380009083A CN104114168A CN 104114168 A CN104114168 A CN 104114168A CN 201380009083 A CN201380009083 A CN 201380009083A CN 104114168 A CN104114168 A CN 104114168A
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day
acceptable salt
days
compound
materia medica
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CN201380009083.4A
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English (en)
Chinese (zh)
Inventor
B.希金斯
K.科林斯基
G.尼科尔斯
K.E.帕克曼
F.苏
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CN201810155251.5A priority Critical patent/CN108295063A/zh
Publication of CN104114168A publication Critical patent/CN104114168A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380009083.4A 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂) Pending CN104114168A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810155251.5A CN108295063A (zh) 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612441P 2012-03-19 2012-03-19
US61/612,441 2012-03-19
PCT/EP2013/055522 WO2013139724A1 (en) 2012-03-19 2013-03-18 Combination therapy (vemrufenib and a mdm2 inhibitor) for the treatment proliferative disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810155251.5A Division CN108295063A (zh) 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂)

Publications (1)

Publication Number Publication Date
CN104114168A true CN104114168A (zh) 2014-10-22

Family

ID=47884369

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380009083.4A Pending CN104114168A (zh) 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂)
CN201810155251.5A Pending CN108295063A (zh) 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂)

Family Applications After (1)

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CN201810155251.5A Pending CN108295063A (zh) 2012-03-19 2013-03-18 治疗增殖性疾病的联合疗法(威罗菲尼和mdm2抑制剂)

Country Status (16)

Country Link
US (2) US9216170B2 (https=)
EP (1) EP2827859B1 (https=)
JP (1) JP6141958B2 (https=)
KR (1) KR101673731B1 (https=)
CN (2) CN104114168A (https=)
AR (1) AR090349A1 (https=)
AU (1) AU2013203637B2 (https=)
BR (1) BR112014018910A8 (https=)
CA (1) CA2861056A1 (https=)
HK (1) HK1201198A1 (https=)
MX (1) MX2014010590A (https=)
NZ (1) NZ626985A (https=)
RU (1) RU2014141362A (https=)
SG (1) SG11201404418QA (https=)
WO (1) WO2013139724A1 (https=)
ZA (1) ZA201405411B (https=)

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US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
US20130245089A1 (en) 2012-03-19 2013-09-19 Hoffmann-La Roche Inc. Method for administration
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US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
KR20190057421A (ko) 2012-08-17 2019-05-28 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
BR112016010564A2 (pt) * 2013-11-11 2017-10-10 Amgen Inc terapia de combinação incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos para tratamento de cânceres
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
KR101862955B1 (ko) * 2013-12-05 2018-05-31 에프. 호프만-라 로슈 아게 급성 골수성 백혈병(aml)을 위한 신규한 병용 치료
EP3131878A1 (en) * 2014-04-15 2017-02-22 F. Hoffmann-La Roche AG Solid forms of a pharmaceutically active compound
TW201613576A (en) * 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CA2972076A1 (en) * 2014-12-23 2016-06-30 Millennium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
CA2976752C (en) 2015-02-20 2019-12-17 Daiichi Sankyo Company, Limited Method for treating cancer by combined use
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
US9890163B2 (en) 2015-10-15 2018-02-13 Princeton Drug Discovery Inc Inhibitors of protein kinases
JP2019507996A (ja) 2015-12-14 2019-03-22 レッド．コム，エルエルシー モジュール式デジタルカメラおよび携帯電話
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN110585433A (zh) * 2019-09-27 2019-12-20 青岛大学 Braf-v600e的抑制剂的应用及用于治疗甲状腺癌的药物

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Also Published As

Publication number Publication date
KR101673731B1 (ko) 2016-11-07
SG11201404418QA (en) 2014-10-30
CA2861056A1 (en) 2013-09-26
RU2014141362A (ru) 2016-05-10
NZ626985A (en) 2016-07-29
US9486445B2 (en) 2016-11-08
MX2014010590A (es) 2014-09-18
EP2827859B1 (en) 2018-10-17
KR20140130179A (ko) 2014-11-07
JP6141958B2 (ja) 2017-06-07
BR112014018910A8 (pt) 2017-07-11
BR112014018910A2 (https=) 2017-06-20
AU2013203637A1 (en) 2013-10-03
JP2015510908A (ja) 2015-04-13
HK1201198A1 (en) 2015-08-28
US9216170B2 (en) 2015-12-22
EP2827859A1 (en) 2015-01-28
CN108295063A (zh) 2018-07-20
US20160051525A1 (en) 2016-02-25
AU2013203637B2 (en) 2016-07-07
WO2013139724A1 (en) 2013-09-26
US20130245039A1 (en) 2013-09-19
ZA201405411B (en) 2019-09-25
AR090349A1 (es) 2014-11-05

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