CN104096208A - Product and drug for treating kidney stone - Google Patents

Product and drug for treating kidney stone Download PDF

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Publication number
CN104096208A
CN104096208A CN201410370090.3A CN201410370090A CN104096208A CN 104096208 A CN104096208 A CN 104096208A CN 201410370090 A CN201410370090 A CN 201410370090A CN 104096208 A CN104096208 A CN 104096208A
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parts
radix
goods
crude drug
semen
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周晓兰
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Abstract

The invention belongs to the field of Chinese materia medica preparation, and provides a product and drug for treating kidney stone, which is the product of submerged fermented mother hyphae of phellinus igniarius, and the submerged fermented medium is the water extracts of the following traditional Chinese medicine as bulk pharmaceutical chemicals in parts by weight: 1-3 parts of fruits of immature citron, 4-6 parts of rheum officinale, 8-12 parts of endothelium corneum gigeriae galli, 8-12 parts of indian buead, 1-3 parts of exocarpium benincasae, 1-3 parts of fresh ginger peels, 6-8 parts of herba pyrrosiae, 8-12 parts of the roots of bidentate achyranthes, 4-6 parts of the seeds of Chinese dodder, 8-12 parts of roasted malt, 8-12 parts of chingma abutilon seeds and 5-8 parts of Aster tataricus L.f. The drug is obvious in effect and quick to become effective and high in cure rate, and is suitable for patients suffering from the kidney stone of various symptoms.

Description

A kind of goods and medicine for the treatment of renal calculus
Technical field
The present invention relates to Chinese medicine preparation, particularly a kind of goods and medicine for the treatment of renal calculus.
Background technology
Calculus is to be accumulated too much by the oxalic acid in food, purine composition is piled up, in unnecessary urine, calcium, oxalates, urate composition increase, and are secondly that carbonate, cystine, sulfonamide, long-term taking are controlled stomach Western medicine, and these crystallised components deposit and form the in-house calculus of urinary system in urine.
Renal calculus is urinary system commonly encountered diseases, frequently-occurring disease, and male falls ill more than women, mostly occurs person between twenty and fifty, the sickness rate no significant difference of left and right sides.There is 40%~75% renal calculus patient to have lumbago in various degree.Calculus is larger, and degree of excursion is very little, shows as the swollen discomfort of waist acid, or in the time that body movement increases, has dull pain or dull pain., often there is the waist and belly sample that lancinates and have an intense pain in the angor causing compared with microlith, is paroxysmal suddenly.
Lithiasis is because of relevant with constitutional, other diseases and dietary habit.Known that urinary calculi has 32 kinds of compositions, modal composition is calcium oxalate.The calculus of other compositions, as ammoniomagnesium phosphate, uric acid, calcium phosphate and cystine (seed amino acid) etc., can be also the mixture of above various compositions.The patient of renal calculus does not have symptom mostly, causes ureteral urine to block unless renal calculus drops to ureter from kidney.Common symptom has lumbago, night sweat, pain to dizzy, nauseating, vomiting, dysphoria, the vexed pain of abdominal part, hematuria etc.If, also may there is the phenomenon such as fear of cold, fever in merging urinary tract infection.Acute kidney angor often makes patient's hurt like hell.Sometimes patient does not have pain completely, only has hematuria, or blood volume is atomic, and naked eyes be can't see.When physical examination, mostly comprise uroscopy, and sediment after centrifugal by microscopy urine, if see that erythrocyte number too much just indicates hematuria, the early stage sign of renal calculus just sometimes.
Little calculus can per urethra Self-discharged, can not the feasible excusing from death lithotrity of Self-discharged person compared with maximum size.Lithotripsy method has extracorporeal shock-wave lithotripsy (ESWL) and liquid surge rubble, ultrasound wave stone and lithotrite rubble.Get stone compared with maximum size and without the feasible surgical operation of rock crushing plant person, the person that has been combined bladder infection, simultaneously active treatment inflammation.
Comprehensive, the misery of bringing to patient with respect to physical method rubble, the therapeutic process comfort level of traditional Chinese medicine lithagogue is higher.
Summary of the invention
The present invention is directed to the demand in above-mentioned field, a kind of goods and medicine for the treatment of renal calculus is provided.This medicine effect instant effect, cure rate are high, are applicable to the renal calculus patient of multiple symptom type.
A kind of goods for the treatment of renal calculus, the Chinese medicine that is following component and weight portion is that crude drug is made: long-pending real 1~3 part, 4~6 parts of Radix Et Rhizoma Rhei, 8~12 parts of Endothelium Corneum Gigeriae Galli, 8~12 parts, Poria, 1~3 part of Exocarpium Benincasae, 1~3 part of CORTEX ZINGIBERIS RHIZOMAE, 6~8 parts of Folium Pyrrosiae, 8~12 parts of Radix Achyranthis Bidentataes, 4~6 parts of Semen Cuscutae, 8~12 parts of Fructus Hordei Germinatus (parched)s, 8~12 parts of Semen Abutilis, 5~8 parts of Radix Asteriss.
Preferred described crude drug is: long-pending real 1 part, and 5 parts of Radix Et Rhizoma Rhei, 12 parts of Endothelium Corneum Gigeriae Galli, 10 parts, Poria, 3 parts of Exocarpium Benincasaes, 3 parts of CORTEX ZINGIBERIS RHIZOMAE, 6 parts of Folium Pyrrosiae, 10 parts of Radix Achyranthis Bidentataes, 5 parts of Semen Cuscutae, 8 parts of Fructus Hordei Germinatus (parched)s, 10 parts of Semen Abutilis, 8 parts of Radix Asteriss.
Preferred described crude drug is: long-pending real 2 parts, and 4 parts of Radix Et Rhizoma Rhei, 10 parts of Endothelium Corneum Gigeriae Galli, 8 parts, Poria, 1 part of Exocarpium Benincasae, 2 parts of CORTEX ZINGIBERIS RHIZOMAE, 7 parts of Folium Pyrrosiae, 12 parts of Radix Achyranthis Bidentataes, 4 parts of Semen Cuscutae, 10 parts of Fructus Hordei Germinatus (parched)s, 12 parts of Semen Abutilis, 7 parts of Radix Asteriss.
Preferred described crude drug is: long-pending real 3 parts, and 6 parts of Radix Et Rhizoma Rhei, 8 parts of Endothelium Corneum Gigeriae Galli, 12 parts, Poria, 2 parts of Exocarpium Benincasaes, 1 part of CORTEX ZINGIBERIS RHIZOMAE, 8 parts of Folium Pyrrosiae, 8 parts of Radix Achyranthis Bidentataes, 6 parts of Semen Cuscutae, 12 parts of Fructus Hordei Germinatus (parched)s, 8 parts of Semen Abutilis, 5 parts of Radix Asteriss.
Preferably above-mentioned arbitrary goods, are the aqueous extract of described crude drug.
Preferably above-mentioned arbitrary goods are the concentrate of the aqueous extract of described crude drug.
A medicine for the treatment of renal calculus, is characterized in that: its effective ingredient is goods claimed in claim 6.
A medicine for the treatment of renal calculus, is characterized in that: its effective ingredient comprises goods claimed in claim 6.
The present invention mostly is and has damp-heat in lower-JIAO according to renal calculus patient, the feature of the symptom such as qi depression to blood stasis or asthenia of both the spleen and kidney, impose clearing away heat-damp and promoting diuresis, promoting flow of QI and blood, training spleen reinforcing kidney, the symptomatic drugs of Tonglin Paishi, the various glandular secretion characteristics of facilitating digestion road and urinary tract, and can assist these secretions to dissolve layer by layer calculus, the lubricated pipeline of urinating, calculus is discharged, in these medicines, also contain several mineral materials, can produce chemical reaction to calculus, impel calculus to strip off, fragmentation, have with the physics rubble means in western medical treatment play the same tune on different musical instruments wonderful, these medicines make calculus lose for a long time pillar without stone composition forms, make the floating layer in surface disappear gradually to fall to diminish, contribute to down to drain through narrow mouthful.Add muchly in these medicines there is treating stranguria effect, have again the function of expansion tube wall, can the calculus diminishing be got rid of external.Outpatient service receives observes 50 routine patients, and cure rate is 85%.
Medicine of the present invention is not only that the simple compatibility of various medicines mixes, but various medical herbs obtains through compatibility meticulously, between each composition, produces synergism.The nature and flavor of the crude drug of medicine of the present invention, cure mainly symptom and source is as follows:
Long-pending real: for Rutaceae kind of plant Citrus aurantium Linn. and variety or Fructus Citri sinensis young fruit.Hardship, is slightly cold.Return spleen, stomach, large intestine channel.Circulation of qi promoting is except distension, the numbness of reducing phlegm out, consumer product dredge stasis.This product can be regulated the flow of vital energy, and can reduce phlegm again, and phlegm-damp is held back to resistance breast sun, hypofunction of YANG QI in chest, thoracic obstruction pain, can join Fructus Trichosanthis, and the product such as Bulbus Allii Macrostemonis, Ramulus Cinnamomi are with using; With control combination of phlegm and heat, the feeling of stuffiness in chest by pain, can join Rhizoma Coptidis, Fructus Trichosanthis is equal to use; Can join Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Rhizoma Gastrodiae for abundant expectoration cough, dizziness due to wind-phlegm etc. and be equal to use.Be used for the diseases such as food stagnation stagnation, constipation stomachache and dysentery are smooth, tenesmus.
Endothelium Corneum Gigeriae Galli, the gizzard inwall of Phasianidae animal man chicken (Gallus gallus domesticus Brisson).Another name: ENDOTHELIUM CORNEUM GIGERIAE GALLI, chicken yellow skin, chicken gizzard, stomach of chicken; Property is hidden and is returned through sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, arresting seminal emission.In addition, this product still can treating stranguria fossil, available sandstone stranguria and gallbladder, the renal calculus etc. controlled, many with Herba Lysimachiae with use.
Poria, English name, Indian Buead, Tuckahoe, Latin plant animal mineral name Wolfiporia cocos (Schw.) Ryv. & Gibn, is under the jurisdiction of Aphyllophorales Aphyllophorales, Polyporaceae Polyporaceae, Poria belongs to Wolfiporia.Be commonly called as Poria, Song Ling, Poria, for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Poria, GUIXIN, lung, spleen, kidney channel.Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." " book on Chinese herbal medicine covers bamboo fish trap ": " enter bladder, kidney, lung." " Thunder God is concocted property of medicine solution ": " enter lung, spleen, small intestinal three warps." " Bencao Jingshu ": " enter brothers few cloudy, the hands sun, lunar, the Yangming Channel of foot." effect: eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.
Exocarpium Benincasae, this product is the dry outer peel of cucurbitaceous plant Fructus Benincasae Benincasa hispida (THunb.) Cogn..When edible Fructus Benincasae, clean, cut and get outer peel, dry.Sweet, cool.Return spleen, small intestine meridian.Cure mainly: inducing diuresis to remove edema, for edema distension, dysuria, summer-heat is thirsty, oliguria with reddish urine.
CORTEX ZINGIBERIS RHIZOMAE, the i.e. crust of Rhizoma Zingiberis Recens.Pungent in flavor and cool in property.The effect that has inducing diuresis to remove edema, is applicable to dysuria, and the diseases such as edema can coordinate Exocarpium Benincasae, Cortex Mori to be equal to use.
Radix Et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L. Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances; Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
Folium Pyrrosiae: be Plants of Polypodiaceae Folium Pyrrosiae, the leaf of pyrrosia sheareriChing, pyrrosia drakeanaChing, pyrrosia petiolosaChing, pyrrosiadavidii or pyrrosia gralla Ching.Diuretic, treating stranguria, lung heat clearing expels the heat-evil, and controls and drenches pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.
Radix Achyranthis Bidentatae: Radix Achyranthis is used as medicine, raw use, promoting blood circulation to restore menstrual flow; Control puerperal abdonimal pain, menoxenia, amenorrhea, epistaxis toothache caused by fire of deficiency type, beriberi edema; Ripe use, invigorating the liver and kidney, strong waist knee joint; Control soreness of waist and knee joint, caused by liver and kidney deficiency, traumatic injury stasis of blood pain.Veterinary, as controlling cattle weak foot disease, gets injured by a fall knochenbruch etc.
Semen Cuscutae: Semen Cuscutae is the mature seed of convolvulus cuscuta plant and southern Semen Cuscutae etc.; There is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the solid tire of spleen invigorating cures mainly lumbago tinnitus, and impotence and seminal emission, quenches one's thirst, sterile, enuresis incontinence, stranguria with turbid discharge leukorrhagia, the head is dim, and lack of appetite is had loose bowels, frequent fetal movement.
Semen Abutili: be the mature seed of Malvaceae annual herb plant Semen Abutili; There is effect of clearing away heat-damp and promoting diuresis, detumescence.Cure mainly urinary obstruction, urinary tract infection, urinary system calculus, lack of lactation after delivery etc.
Radix Asteris: formal name used at school: Aster tataricus L.f., another name: Qing Yuan, purple pretty, plait etc.; Compositae Aster, perennial herb, all herbal medicine.Function cures mainly: warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, cough-relieving.Control cough due to wind and cold's asthma, asthenia is coughed vomiting bloody pus, sore throat, dysuria.
Goods of the present invention can directly be taken, and also can add pharmaceutically acceptable adjuvant and make the medicine of various dosage forms.
Detailed description of the invention
It is in order further to understand better the present invention that following embodiment is provided; be not limited to described preferred forms; content of the present invention and protection domain are not construed as limiting; anyone under enlightenment of the present invention or by the present invention, combines with the feature of other prior aries and any and the present invention of drawing is identical or akin product, within all dropping on protection scope of the present invention.
The preparation of 1.1~No. 3 goods of embodiment
No. 1 goods formula (weight portion): long-pending real 1 part, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Endothelium Corneum Gigeriae Galli, 10 parts, Poria, 3 parts of Exocarpium Benincasaes, 3 parts of CORTEX ZINGIBERIS RHIZOMAE, 6 parts of Folium Pyrrosiae, 10 parts of Radix Achyranthis Bidentataes, 5 parts of Semen Cuscutae, 8 parts of Fructus Hordei Germinatus (parched)s, 10 parts of Semen Abutilis, 8 parts of Radix Asteriss.
Preparation process:
(1) take altogether 30kg by crude drug recipe ingredient,
(2) add the water of 5~6 times of raw material of Chinese medicine medicine total amounts, big fire is boiled, and little fire decocts, and each 0.5 hour, filters extracting juice;
(3) repeat (2) 5 times, collect all filtrate and must amount to the about 45kg Chinese medicine of weight aqueous extract.
No. 1 goods dose is: in 24 hours, divide and take several times 0.45 kg water extracting solution altogether, be equivalent to take the goods of 0.3 kg feed material.It within 10 days, is a course for the treatment of.
No. 2 goods formulas (weight portion): long-pending real 2 parts, 4 parts of Radix Et Rhizoma Rhei, 10 parts of Endothelium Corneum Gigeriae Galli, 8 parts, Poria, 1 part of Exocarpium Benincasae, 2 parts of CORTEX ZINGIBERIS RHIZOMAE, 7 parts of Folium Pyrrosiae, 12 parts of Radix Achyranthis Bidentataes, 4 parts of Semen Cuscutae, 10 parts of Fructus Hordei Germinatus (parched)s, 12 parts of Semen Abutilis, 7 parts of Radix Asteriss.
Preparation process:
(1) take altogether 30kg by crude drug recipe ingredient,
(2) add the water of 5~6 times of raw material of Chinese medicine medicine total amounts, big fire is boiled, and little fire decocts, and each 0.5 hour, filters extracting juice;
(3) repeat (2) 5 times, collect all filtrate and must amount to the about 120kg Chinese medicine of weight aqueous extract.
(4) concentrate, dry, the powder 3kg that sieves to obtain, adds 10% Mel to make oral pills, 5 grams of powders of every ball.
No. 2 goods dose is: in 24 hours, a point several one after each meal has 6 pills altogether, is equivalent to take the goods of 0.3 kg feed material medicine.It within 10 days, is a course for the treatment of.
No. 3 goods formulas (weight portion): long-pending real 3 parts, 6 parts of Radix Et Rhizoma Rhei, 8 parts of Endothelium Corneum Gigeriae Galli, 12 parts, Poria, 2 parts of Exocarpium Benincasaes, 1 part of CORTEX ZINGIBERIS RHIZOMAE, 8 parts of Folium Pyrrosiae, 8 parts of Radix Achyranthis Bidentataes, 6 parts of Semen Cuscutae, 12 parts of Fructus Hordei Germinatus (parched)s, 8 parts of Semen Abutilis, 5 parts of Radix Asteriss.
Preparation process:
(1) take altogether 35kg by crude drug recipe ingredient,
(2) add the water of 5~6 times of raw material of Chinese medicine medicine total amounts, big fire is boiled, and little fire decocts, and each 0.5 hour, filters extracting juice;
(3) repeat (2) 5 times, collect all filtrate and must amount to the about 125kg Chinese medicine of weight aqueous extract.
(4) concentrate, dry, the powder 3.5kg that sieves to obtain, adds 10% Mel to make oral pills, and 5 grams of powders of every ball obtain goods No. 3
No. 3 goods dose is: in 24 hours, a point several one after each meal has 6 pills altogether, is equivalent to take the goods of 0.3 kg feed material medicine.It within 10 days, is a course for the treatment of.
Experimental example. clinical statistics
Case 42 examples that Western medicine diagnose is renal calculus are observed in outpatient service, divide three groups, every group of 14 people.
Take respectively 1~No. 3 goods that embodiment 1 prepares, take after 10 days, all 42 patients reflect that symptom takes a turn for the better.After two courses for the treatment of, there is 28 people's clinical symptoms all to disappear (and discharging more than 50, calculus), and in three months, have no recurrence, in all patients, have no uncomfortable.

Claims (8)

1. treat the goods of renal calculus for one kind, the Chinese medicine that is following component and weight portion is that crude drug is made: long-pending real 1~3 part, 4~6 parts of Radix Et Rhizoma Rhei, 8~12 parts of Endothelium Corneum Gigeriae Galli, 8~12 parts, Poria, 1~3 part of Exocarpium Benincasae, 1~3 part of CORTEX ZINGIBERIS RHIZOMAE, 6~8 parts of Folium Pyrrosiae, 8~12 parts of Radix Achyranthis Bidentataes, 4~6 parts of Semen Cuscutae, 8~12 parts of Fructus Hordei Germinatus (parched)s, 8~12 parts of Semen Abutilis, 5~8 parts of Radix Asteriss.
2. goods according to claim 1, described crude drug is: long-pending real 1 part, 5 parts of Radix Et Rhizoma Rhei, 12 parts of Endothelium Corneum Gigeriae Galli, 10 parts, Poria, 3 parts of Exocarpium Benincasaes, 3 parts of CORTEX ZINGIBERIS RHIZOMAE, 6 parts of Folium Pyrrosiae, 10 parts of Radix Achyranthis Bidentataes, 5 parts of Semen Cuscutae, 8 parts of Fructus Hordei Germinatus (parched)s, 10 parts of Semen Abutilis, 8 parts of Radix Asteriss.
3. goods according to claim 1, described crude drug is: long-pending real 2 parts, 4 parts of Radix Et Rhizoma Rhei, 10 parts of Endothelium Corneum Gigeriae Galli, 8 parts, Poria, 1 part of Exocarpium Benincasae, 2 parts of CORTEX ZINGIBERIS RHIZOMAE, 7 parts of Folium Pyrrosiae, 12 parts of Radix Achyranthis Bidentataes, 4 parts of Semen Cuscutae, 10 parts of Fructus Hordei Germinatus (parched)s, 12 parts of Semen Abutilis, 7 parts of Radix Asteriss.
4. goods according to claim 1, described crude drug is: long-pending real 3 parts, 6 parts of Radix Et Rhizoma Rhei, 8 parts of Endothelium Corneum Gigeriae Galli, 12 parts, Poria, 2 parts of Exocarpium Benincasaes, 1 part of CORTEX ZINGIBERIS RHIZOMAE, 8 parts of Folium Pyrrosiae, 8 parts of Radix Achyranthis Bidentataes, 6 parts of Semen Cuscutae, 12 parts of Fructus Hordei Germinatus (parched)s, 8 parts of Semen Abutilis, 5 parts of Radix Asteriss.
5. according to the arbitrary described goods of claim 1~4, be the aqueous extract of described crude drug.
6. according to the arbitrary described goods of claim 1~4, be the concentrate of the aqueous extract of described crude drug.
7. a medicine for the treatment of renal calculus, is characterized in that: its effective ingredient is goods claimed in claim 6.
8. a medicine for the treatment of renal calculus, is characterized in that: its effective ingredient comprises goods claimed in claim 6.
CN201410370090.3A 2014-07-30 2014-07-30 Product and drug for treating kidney stone Pending CN104096208A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT95108A (en) * 1995-10-12 1996-08-26 Pranas Karvelis The herbal formulation for treating kidney stone disease
CN102309709A (en) * 2011-09-25 2012-01-11 董连军 Medicine for treating vesical calculus
CN103356797A (en) * 2013-06-21 2013-10-23 潍坊诺达药业有限公司 Chinese medicine composition for treating kidney stone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT95108A (en) * 1995-10-12 1996-08-26 Pranas Karvelis The herbal formulation for treating kidney stone disease
CN102309709A (en) * 2011-09-25 2012-01-11 董连军 Medicine for treating vesical calculus
CN103356797A (en) * 2013-06-21 2013-10-23 潍坊诺达药业有限公司 Chinese medicine composition for treating kidney stone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王清波等: "排石饮治疗泌尿系结石52例临床观察", 《工企医刊》 *

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Application publication date: 20141015