CN104095998A - Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof - Google Patents
Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof Download PDFInfo
- Publication number
- CN104095998A CN104095998A CN201410373972.5A CN201410373972A CN104095998A CN 104095998 A CN104095998 A CN 104095998A CN 201410373972 A CN201410373972 A CN 201410373972A CN 104095998 A CN104095998 A CN 104095998A
- Authority
- CN
- China
- Prior art keywords
- extract
- chinese medicine
- stomach
- spleen
- invigorating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as a preparation process and application thereof, and belongs to the technical field of extraction of traditional Chinese medicinal materials. The traditional Chinese medicine extract is an extract of eurya hebeclados. The traditional Chinese medicine extract related to the invention is prepared from a single Chinese herbal medicine, has the efficacies of enriching qi, nourishing blood, invigorating the spleen and harmonizing the stomach, can quicken gastrointestinal peristalsis, and is suitable for treating patients suffering from qi and blood deficiency, deficiency-cold of spleens and stomachs, tiredness and lacking of strength, and indigestion.
Description
Technical field
The invention belongs to Chinese crude drug extractive technique field, relate to a kind of Chinese medicine extract and preparation technology and application of invigorating the spleen and regulating the stomach.
Background technology
The spleen and stomach provide the material basis of the acquired, is source of generating QI and blood.People often says that " ten people's nine stomaches " meaning refers to that most people all exists gastropathy in various degree, and mostly gastropathy is that dyspepsia or congenital weakness of the spleen and stomach cause.This sick medicine for the treatment of is a lot of at present, and Western medicine has Martin's quinoline etc., and Chinese medicine has JIANWEI XIAOSHI PIAN in river, children's's relieving dyspepsia ball, these medicines are irregular to diet, and the anorexia that dyspepsia causes has certain effect, but the dyspepsia anorexia that weakness of the spleen and stomach is caused does not just have effect.
Microtriche Eurya plant is shrub, and high 2-3mm twig is cylindrical, has microtriche.Leaf alternate, keratin; Petiole has microtriche; The oval shape ellipse of blade, long 4-8cm, wide 1.5-3cm, the sharp point of tip, base portion wedge shape, there is serration at edge.Flower unisexuality, dioecism; Floral white, 2-5 axil is raw; Sepal subcircular, has microtriche below; Male flower petal obovate, stamen 15, style is about lmm, 3 drastic cracks.Spherical fruit, diameter 4-5mm.Be distributed in Anhui, Jiangxi, Hunan, Guizhou and southeastern coast various places.
At present, this medical material effect that there is dispeling the wind, subsides a swelling, detoxifies, stops blooding that is in the news, often be used to the diseases such as rheumatic arthritis, hepatitis, innominate toxic swelling, scald, traumatic injury, traumatic hemorrhage, venom, there is no effect that bibliographical information microtriche Eurya plant or its extract have invigorating the spleen and regulating the stomach or promote gastrointestinal motility.
Summary of the invention
For the card of weakness of the spleen and stomach, incoordination between the spleen and stomach, the object of the present invention is to provide a kind of Chinese medicine extract and preparation technology and application of invigorating the spleen and regulating the stomach.
In order to realize the object of instinct invention, inventor studies and persistent exploration by lot of experiments, has finally obtained following technical scheme:
A Chinese medicine extract for invigorating the spleen and regulating the stomach, described Chinese medicine extract is microtriche Eurya plant extract.It should be noted that, Chinese crude drug microtriche Eurya plant of the present invention is selected the tender leaf of plant of theaceae microtriche Eurya plant Eurya hebecladosL.K.Ling, and this tender leaf can be the fresh goods of just plucking, and can be also the dry product after drying.
A kind of preparation technology of Chinese medicine extract of above-mentioned invigorating the spleen and regulating the stomach, the alcoholic solution reflux, extract, that it is 93-95% that this technique comprises the steps: microtriche Eurya plant volumetric concentration 1-4 time, extracting solution is dissolved in water after removing ethanol, then first use petroleum ether extraction, the aqueous portion after extraction is extracted with ethyl acetate again, and gained ethyl acetate is mutually partly through reclaiming solvent, be condensed into thick paste, dry, pulverize, obtain microtriche Eurya plant extract.
The inventor, taking retention of dampness in middle-JIAO card rat as model, studies the impact of microtriche Eurya plant extract on rat model intestinal propulsion rate and level of serum gastrin.Experimental pharmacology data show retention of dampness in middle-JIAO card rat intestine advances and weakens, and gives microtriche Eurya plant extract hindgut and advances obviously reinforcement.In addition, gastrin is one of most important hormone of gastrointestinal tract, its shortterm effect is mainly to stimulate gastric acid, pepsinogen, pancreatin secretion, stimulate gastric antrum to shrink, promote gastrointestinal motility, increase Gastric Mucosa Blood Flow amount etc., its normal secretion is digestion, the absorption, emptying that ensures stomach, maintains gastric mucosa nutrition indispensable.Gastrin Levels reduces can cause gastric acid minimizing, cause that digestive function reduces, produce the symptoms such as abdominal distention, diarrhoea, and result of the test of the present invention shows that microtriche Eurya plant extract can significantly strengthen the level of retention of dampness in middle-JIAO card rat stomach secretin, this is indicating that microtriche Eurya plant extract has invigorating the spleen and regulating the stomach effect very significantly.Based on this result of study, another object of the present invention is to provide a kind of pharmaceutical applications, that is: the application of above-mentioned microtriche Eurya plant extract in the medicine of preparing invigorating the spleen and regulating the stomach.Further preferably: the application in the medicine that above-mentioned microtriche Eurya plant extract is wriggled in preparation accelerate gastrointestinal.
Compared with prior art, the Chinese medicine extract the present invention relates to is prepared from by single Chinese herbal medicine, and it has benefiting qi and nourishing blood, and effect of invigorating the spleen and regulating the stomach can accelerate gastrointestinal be wriggled, and is applicable to deficiency of both QI and blood, Deficiency and coldness of spleen and stomach, fatigue and weakness, dyspepsia patient's treatment.
Detailed description of the invention
Be below Preparation Example and the effect test example of microtriche Eurya plant extract dry powder of the present invention, the present invention will be further described.But protection scope of the present invention is not limited to following examples, every technology realizing based on foregoing of the present invention all belongs to scope of the present invention.
The preparation of embodiment 1 microtriche Eurya plant extract dry powder
Microtriche Eurya plant dry product 0.82kg, pulverizes, and crosses 40 mesh sieves, be 10,8,6 times of amount 95%(v/v with volume mass ratio respectively) alcoholic solution reflux, extract, 3 times, merge 3 times extracting solution, rotary evaporation is concentrated into without alcohol taste, adding distil water 1L dissolves, and first uses isopyknic petroleum ether extraction 2 times, and aqueous portion merges with isopyknic ethyl acetate extraction 3 times, ethyl acetate mutually part reclaims solvent through rotary evaporation, be condensed into thick paste, lyophilization, is ground into fine powder, cross 100 mesh sieves, obtain microtriche Eurya plant extract dry powder.
The affect experimental study of embodiment 2 microtriche Eurya plant extracts on retention of dampness in middle-JIAO rat blood serum gastrin and intestinal propelling
48 of SD rats, body weight (150 ± 20) g, male and female half and half, are divided into that Normal group, model control group, microtriche Eurya plant extract are low, high dose group at random, 12 every group.Except normal group, other each group rat modeling 7d as follows: the bucket went swimming 15min of 25 DEG C of depth of water 25cm, water temperature is put in timing every day, after swimming, press immediately 25mL/kg in the 1st, 3,5, within 7 days, gavage gives lard oil, the 2nd, it is 30% Mel that 4,6 days gavages give concentration, rat is placed in and bedding and padding 200g is housed and the large mouse cage that waters with 1000mL water is raised, cover with plastic sheeting.The rat of normal group is fed in home.
Second day after modeling, taking weight as benchmark, each group is respectively according to the tested material gastric infusion of following dosage 7 days, every day each 1 time sooner or later:
Normal group: normal saline 15ml/kg;
Model control group: normal saline 15ml/kg;
Microtriche Eurya plant extract low dose group: microtriche Eurya plant extract dry powder prepared by embodiment 1 40mg/kg/ time;
Microtriche Eurya plant extract high dose group: microtriche Eurya plant extract dry powder prepared by embodiment 1 120mg/kg/ time.
Before the administration of each group rat last, water is can't help in 12h fasting, after last administration 1h, rat is pressed the freshly prepared carbon granule suspension of 10mL/kg gavage (active carbon and Radix Acaciae senegalis are respectively containing 10%), after 15min, put to death rat with spinal cord dislocation method immediately, broken end is got blood, 4-5 DEG C of centrifugalize goes out serum, detects Gastrin Levels in serum; Get and take out immediately small intestinal after blood and pave, survey small intestinal total length and powdered carbon suspension and push to from sphincter of pylorus the distance of distal small intestine, calculating intestinal propulsion rate.Intestinal propulsion rate=charcoal end advances length/small intestinal length × 100%.Result of the test is in table 1.
Result of the test by table 1 can find out, compared with Normal group, the Gastrin Levels of model group rat and intestinal propulsion rate significantly reduce (
p< 0.01 or
p< 0.05), the success of retention of dampness in middle-JIAO model copy is described.In addition, with model control group comparison, in the each dosage group of extract serum, Gastrin Levels and intestinal propulsion rate obviously raise, and high dose group Gastrin Levels and intestinal propulsion rate are higher than low dose group, this is indicating that microtriche Eurya plant extract of the present invention can strengthen invigorating the spleen and regulating the stomach effect, and has dose dependent.
Table 1 each group rat Gastrin Levels and the comparison of intestinal propulsion rate
Model control group and the comparison of blank group,
● p< 0.05,
● ● p< 0.01;
Treatment group and model control group comparison,
★ p< 0.05,
★ ★ p< 0.01.
Claims (4)
1. a Chinese medicine extract for invigorating the spleen and regulating the stomach, is characterized in that: described Chinese medicine extract is microtriche Eurya plant extract.
2. the preparation technology of the Chinese medicine extract of invigorating the spleen and regulating the stomach according to claim 1, it is characterized in that this technique alcoholic solution reflux, extract, that to comprise the steps: microtriche Eurya plant volumetric concentration be 93-95% 1-4 time, extracting solution is dissolved in water after removing ethanol, then first use petroleum ether extraction, the aqueous portion after extraction is extracted with ethyl acetate again, and gained ethyl acetate is mutually partly through reclaiming solvent, be condensed into thick paste, dry, pulverize, obtain microtriche Eurya plant extract.
3. the application of microtriche Eurya plant extract claimed in claim 1 in the medicine of preparing invigorating the spleen and regulating the stomach.
4. the application in the medicine that microtriche Eurya plant extract claimed in claim 1 is wriggled in preparation accelerate gastrointestinal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410373972.5A CN104095998A (en) | 2014-08-01 | 2014-08-01 | Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410373972.5A CN104095998A (en) | 2014-08-01 | 2014-08-01 | Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104095998A true CN104095998A (en) | 2014-10-15 |
Family
ID=51664790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410373972.5A Withdrawn CN104095998A (en) | 2014-08-01 | 2014-08-01 | Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104095998A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634455A (en) * | 2004-11-25 | 2005-07-06 | 张平 | Spleen invigorating appetizing effervescence tablet for children and preparation method thereof |
| CN1772085A (en) * | 2005-11-08 | 2006-05-17 | 周卓和 | Extract for treating functional indigestion and its medicine composition |
-
2014
- 2014-08-01 CN CN201410373972.5A patent/CN104095998A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634455A (en) * | 2004-11-25 | 2005-07-06 | 张平 | Spleen invigorating appetizing effervescence tablet for children and preparation method thereof |
| CN1772085A (en) * | 2005-11-08 | 2006-05-17 | 周卓和 | Extract for treating functional indigestion and its medicine composition |
Non-Patent Citations (2)
| Title |
|---|
| 戴光强: "《医院药学 医院中药学分册》", 30 April 2001, 安徽科学技术出版社 * |
| 石祥刚，等: "应用HPLC色谱技术进行柃属植物化学分类学研究", 《中山大学学报（自然科学版）》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109674054A (en) | A kind of preparation method of the oligomeric saccharide complex of water solubility curcumin and its solid beverage | |
| CN104222638A (en) | Functional feed for preventing and treating carp branchiomycosis and preparation method of functional feed | |
| CN103054993A (en) | Traditional Chinese veterinary drug preparation for treating porcine diarrhea, and preparation method thereof | |
| CN106902187A (en) | A kind of tea bag for preventing and treating gout | |
| CN108210477A (en) | Delay flexible glue cyst fluid, soft capsule and the forefront capsule and its preparation method of rubber aging | |
| CN106822579A (en) | Composition with treatment osteoporosis effect and its preparation method and application | |
| CN101104056B (en) | Medicine for treating lung carbuncle and its preparation method | |
| CN105617021A (en) | Medicine or health product taking dendrobium officinale and beautiful millettia root as raw materials | |
| CN104095998A (en) | Traditional Chinese medicine extract with functions of invigorating spleen and harmonizing stomach as well as preparation process and application thereof | |
| CN104257809B (en) | A kind of preparation method who treats constipation Tibetan medicine | |
| CN103933100A (en) | Preparation method of total alkaloid of Chinese mahonia stem and applications of total alkaloid of Chinese mahonia stem in preparation of drugs for preventing and treating gastric ulcer | |
| CN103191243B (en) | Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition | |
| CN101474315B (en) | Effective component group of stem-bark or root-bark of Daphne giraldii as well as preparation method and use thereof | |
| CN104784621A (en) | Traditional Chinese medicine composition for treating diarrhea, and preparation method and application thereof | |
| CN104491338B (en) | A kind of medicine-food dual-purpose composition to relax bowel and preparation method thereof | |
| CN104784651B (en) | A kind of method for preparing the pharmaceutical preparation for treating gastric ulcer | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN103127462B (en) | Medicine used for treating swollen sore throat | |
| CN106620474A (en) | Stomach-nourishing health medicine and preparation method thereof | |
| CN108096346B (en) | Qianluoye cherry pit composition, preparation method thereof and application thereof in preparation of gastrointestinal motility promoting medicine | |
| CN101757460A (en) | Traditional Chinese medicine preparation for treating gout | |
| CN107126463A (en) | A kind of anti-diarrhea Chinese medical extract and its application | |
| CN106511394A (en) | Novel application of fatty oil extract of aspongopus | |
| CN100358575C (en) | Medicine for treating gastric cavity pains, process for preparing the same and application thereof | |
| CN101244041A (en) | Medicament for preventing and treating acute liver damnification and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xu Guangxia Inventor before: Liu Xuejian |
|
| CB03 | Change of inventor or designer information | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20141015 |
|
| WW01 | Invention patent application withdrawn after publication |