CN104095766A - Sophorolipid-enhanced anti-dandruff composition and application thereof - Google Patents
Sophorolipid-enhanced anti-dandruff composition and application thereof Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- ZTOKUMPYMPKCFX-CZNUEWPDSA-N (E)-17-[(2R,3R,4S,5S,6R)-6-(acetyloxymethyl)-3-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxyoctadec-9-enoic acid Chemical compound OC(=O)CCCCCCC/C=C/CCCCCCC(C)O[C@@H]1O[C@H](COC(C)=O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(C)=O)O1 ZTOKUMPYMPKCFX-CZNUEWPDSA-N 0.000 title claims abstract description 37
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 37
- 210000004209 hair Anatomy 0.000 claims abstract description 23
- 239000002453 shampoo Substances 0.000 claims abstract description 21
- 229940043810 zinc pyrithione Drugs 0.000 claims abstract description 20
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 206010040844 Skin exfoliation Diseases 0.000 claims description 28
- 230000035618 desquamation Effects 0.000 claims description 28
- 150000002596 lactones Chemical class 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 239000011701 zinc Substances 0.000 abstract description 2
- 229910052725 zinc Inorganic materials 0.000 abstract description 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
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- 238000011156 evaluation Methods 0.000 description 7
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- 230000000843 anti-fungal effect Effects 0.000 description 5
- 229940121375 antifungal agent Drugs 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
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- 239000000126 substance Substances 0.000 description 4
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
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- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 2
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000555688 Malassezia furfur Species 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- 241000193622 Wickerhamiella domercqiae Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 2
- 239000003876 biosurfactant Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 229960003344 climbazole Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 229960004125 ketoconazole Drugs 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- LOEUPVXIWVJADW-UHFFFAOYSA-N 2-aminoethanol;1h-pyridin-2-one Chemical compound NCCO.O=C1C=CC=CN1 LOEUPVXIWVJADW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 241000222065 Lycoperdon Species 0.000 description 1
- 241000555676 Malassezia Species 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000768494 Polymorphum Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical class [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 description 1
- 229960001915 hexamidine Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 230000003571 opsonizing effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 125000003152 sophorose group Chemical group 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to sophorolipid-enhanced anti-dandruff composition and an application of the anti-dandruff composition in hair shampoo and hair care products. The anti-dandruff composition is water suspension comprising components in percentage by weight as follows: 2.0%-20.0% of pyrithionc zinc, 5.0%-15.0% of a sophorolipid product, 0.3%-2.0% of high-molecular polymer and 63.0%-92.7% of water or/and alcohol, wherein the sophorolipid product has a synergistic effect of inhibition and dandruff removal on zinc pyrithione. The invention further relates to an application of the anti-dandruff composition in hair shampoo and hair conditioner.
Description
Technical field
The invention belongs to cosmetics of everyday use field, relate to a kind of desquamation compositions and application thereof of sophorolipid potentiation, being specifically related to a kind of Zinc Pyrithione of wrapping is desquamation compositions and the application thereof that main anti-dandruff active component and sophorolipid are synergist.
Background technology
Dandruff problem usually perplexs people's the various aspects such as work, life and social activity.Pathologic dandruff may be periodically, recurrently occur, and can arrive and cause scalp hair follicle impaired, formation permanent alopecia when serious.Fungus amount reproduction on scalp that pathologic dandruff is generally considered to a kind of chlosma (Malassezia) causes the cuticular hyperplasia of scalp, thereby impels corneocyte extremely to come off with the form of white or Lycoperdon polymorphum Vitt squama, forms dandruff.The chlosma that this kind causes dandruff is unit cell yeast, also referred to as pityrosporum furfur.Chlosma does not have independently activeness, and it absorbs fatty acid and survives from sebaceous gland lipid, and after the satisfied fatty acid that the triglyceride in consumption sebum decomposes out, remaining unsaturated fatty acid infiltrates through scalp, causes the inflammatory reaction of human body.The scalp physiological structure abnormal phenomenas such as when inflammatory reaction occurs, scalp cells proliferative disorder accelerates, incomplete, the abnormal cutin tunicle of horn cell keratinization, finally cause cells of superficial layer large area to come off, and form dandruff.Suppressing theoretically sebum secretion and adopting antifungal is all effective anti-dandruff way; In practice, conventionally select effective Active antifungal compound, people have developed the highly active antifungal actives that minimal inhibitory concentration is 1-30ppm, comprise selenium sulfide, Zinc Pyrithione (ZPT), ketoconazole (Ketoconazole), climbazole (Climbazole) and pyridone ethanolamine (OCT), hexamidine two (ethoxy) sulfonate, endecatylene derivant etc.Wherein Zinc Pyrithione have good anti-dandruff effect, conventional amount used to human body have no side effect, moderate cost, be the first-selection of anti-dandruff product always
Hair washing product and hair products are hair caring and the basic nursing product that keep scalp health, be also control dandruff commonly use, obtain universally recognized method.The sterilizing mechanisms of ZPT is its lipotropy and chelation.Therefore exploitation can effectively be transported to active component the physical support of scalp surface, and exploitation is dissolved in sebum effectively for the chemical activation system of chlosma absorption by active component, becomes and washes the important technology innovative point that protects formula for a product.Moreover ZPT dissolubility in water extremely low (8ppm), often adopts suspension system to improve the stability of ZPT in formula.
Sophorolipid is that fatty acid is connected to the compounds forming on disaccharide (sophorose) residue by glycosidic bond, hydrophilic carbohydrate and hydrophobic lipid, partly consists of, and has interfacial activity or surface activity feature; Sophorolipid mostly is microbial metabolic products at present, therefore also referred to as biosurfactant.Its bacteriostasis has been found and has applied.
The win wound Gauss special CN 102548398A of rice (201080043285.7) has described sophorolipid and derivant is combined pesticide in the purposes of conduct protection and industrial circle as adjuvant/additive.
CN 101886047B (201010191707.7) describes sophorolipid and suppresses fruit fungus, as the commercial use of fruit-preservative; 6 strains that described fruit fungus relates to Penicillium, aspergillus and mucor cause rotten bacterium.
PCT/US2005/046426 (WO2006/069175) describes sophorolipid and is used as the commercial use of antifungal and the application of the emulsifying agent of the oil-in-water type that conduct has antifungal character in cosmetics, household cleaning product thereof.
The application of CN 101199539 B (200710114796.3) application protection sophorolipid in the anti-Pi Fu Ban Xian bacterium medicine of preparation, comprises sophorolipid application in the anti-pityrosporum furfur medicine of preparation as the compositions of effective ingredient.
On the basis of above research invention, the present invention is the exploitation for anti-dandruff product by sophorolipid, finds to have the conventional anti-dandruff dose of antibacterial anti-dandruff effect of Zinc Pyrithione of Synergistic, adds less Zinc Pyrithione and can reach same anti-dandruff effect.In prior art, also there is no evidence prove sophorolipid and the anti-dandruff dose of synergy that interaction is such.
Summary of the invention
Desquamation compositions is to be a main anti-dandruff active component by Zinc Pyrithione, the suspension system that the sophorolipid of take is synergist.
Described desquamation compositions suspension system comprises: Zinc Pyrithione percentage by weight is 2.0-20.0%; Sophorolipid goods synergist percentage by weight is 5.0-15.0%; High molecular polymer suspension dispersive agent percentage by weight is 0.3-2.0%; Water is or/and alcohol weight ratio 63.0-92.7%.
The particle diameter of described anti-dandruff active component Zinc Pyrithione is 1.0-5.0 micron.
In described sophorolipid synergist goods, sophorolipid percentage by weight is greater than 70%; Sophorolipid exists as the mixture of lactone (I) and acid (II) form, and the part that is preferably greater than 90% weight ratio is lactone (I) form;
Described high molecular polymer suspending agent is selected from a kind of of aluminium-magnesium silicate, acrylate copolymer or its combination in any.
Described desquamation compositions is washed the application in hair products at the anti-dandruff type shampoo of preparation, hair conditioner,
Described desquamation compositions is 0.5-2.0% interpolation by weight percentage in shampoo, at hair conditioner, is that 0.2-1.0% adds by weight percentage.
The detailed description of invention
Sophorolipid synergist of the present invention is the sophorolipid goods that Wickerhamiella domercqiae var. sophorolipid (Wickerhamiella domercqiae var.sophorolipid) fermentation produces, and wherein sophorolipid percentage by weight is for being greater than 70%; Sophorolipid exists as the mixture of lactone and sour form, and the part that is preferably greater than 90% weight ratio is lactone form, can dissolve by adjusting pH to 6-8.
Zinc Pyrithione of the present invention is heterocyclic compound, and molecular formula is C
10h
8n
2o
2s
2zn, chemical name is two (1-hydroxyl-2 (1H) pyridine-O, S) zinc, structural formula is as follows:
Zinc Pyrithione particle diameter of the present invention is 1.0-5.0 micron, can fly auspicious chemical industry and tide emblem, Shantou chemical products for be bestowed by heaven company, Guangzhou of U.S. Ao Qi company, Guangzhou.
High molecular polymer of the present invention is to be selected from a kind of of aluminium-magnesium silicate, acrylate copolymer or its combination in any; Preferred acrylate copolymer can be U20, the U21,980 of Lubrizol Corp., 981 and emulsion acrylic polymer SF-1.
Dandruff control shampoo containing of the present invention is shampoo conventional formulation, except the described desquamation compositions containing percentage by weight 0.5-2.0%, also comprise following component of adding according to percentage by weight: anion surfactant 10-25%, amphoteric surfactant/non-ionic surface active agent 2-10%, cation opsonizing agent 1.0-5.0%, emulsified silicone oil 0-3.0%, pearling agent 0-2.0%, thickening agent 0.3-5.0%, antiseptic, essence are appropriate; Pay special attention to not add the metal ion chelation agents such as EDTA in formula.
Anti-dandruff hair conditioner of the present invention is conventional formulation, except the described desquamation compositions containing percentage by weight 0.2-1.0%, also comprise following component of adding according to percentage by weight: C16/C18/C22 alkyl trimethyl ammonium chloride/couple h-tallow fat base alkyl dimethyl ammonium chloride/stearyl benzyl dimethyl ammonium chloride 0.8-1.5%, C16/C18 alcohol 2.0-15%, emulsified silicone oil 0-3.0%, glyceryl monostearate 0-0.6%, C16 alkyl (EO) 20 ether 0-0.5%; Thickening agent 0-2.0%, antiseptic, essence are appropriate; Pay special attention to not add the metal ion chelation agents such as EDTA in formula.
The beneficial effect of the invention
Desquamation compositions sophorolipid goods of the present invention are as the synergist of anti-dandruff dose of Zinc Pyrithione, one is that sophorolipid itself has the bacteriostasis of antidandruff fungus (pityrosporum furfur), its two be with the hydrophilic and oleophilic ratio (HLB) of sophorolipid less, there is the Zinc Pyrithione of assistance and be dissolved in the effect of sebum, thereby strengthen its bactericidal action; Its three sophorolipid is gentle biosurfactant, and itself is less on washing the foaming properties impact of hair products, and can alleviate the defat phenomenon that dandruff control shampoo containing causes.Therefore, the present invention may be interpreted as Zinc Pyrithione and sophorolipid has synergism, and synergism is interpreted as in this article and represents that anti-dandruff dose is greater than the Expected Results of two kinds of independent components with the combined effect of sophorolipid.
The non-limiting example of composition of detergent of the present invention below.The providing of these embodiment is only used to the object of explanation, can not be interpreted as limitation of the invention, because without departing from the spirit and scope of the present invention, can carry out many changes to the present invention.In these embodiments, unless stated otherwise, all concentration is all percentage by weight.
The specific embodiment
1. embodiment I-VII desquamation compositions
Table 1 desquamation compositions embodiment constituent
Desquamation compositions Detection of Stability
Desquamation compositions stability test condition is respectively: 48 ℃ of heat-resistant stabilities, 5 weeks;-18 ℃ of cold-resistant experiments, 24h, returns to room temperature and observes, totally 5 circulations.I-VII colloid is all stable without layering, without separating out.
2. the application of desquamation compositions I-VII in shampoo
2.1 application of desquamation compositions I-VII in shampoo: desquamation compositions embodiment I-VII is added according to 0.5% and 2.0% percentage by weight respectively, shampoo matrix components is identical, by following compositions in weight percentage, formed: polyoxyethylene lauryl ether ammonium sulfate-70,10%; Ammonium lauryl sulfate salt-70,5%; Cocoyl CAB-35,4%; Coconut palm oleoyl monoethanolamine, 1.5% cation guar gum, 0.4%, citric acid, 0.1%; Emulsified silicone oil 3.0%; The water of appropriate antiseptic and essence and surplus.The effect detection of 2.2 application of desquamation compositions I-VII in shampoo:
2.2.1 fungistatic effect detects: adopt the antibacterial around-France fungistatic effect detection of carrying out: bacterial strain uses therefor is Malassezia furfur reference culture (Malassezia furfur ATCC44344); Used medium is Leeming & Notman agar culture medium.The larger anti-dandruff antibacterial effect of bacteriostatic diameter may be higher.
Table 2 shampoo composite fungistatic effect is evaluated
2.2.2 anti-dandruff effect sensory evaluation
Described sensory evaluation method is: by 14 embodiment, issue respectively 120 testers and contrast use.When tester uses shampoo sample, according to identical method hair washing, every kind of shampoo is used 4 weeks.Anti-dandruff effect is according to how many next and tested personnel's sensory effects scorings with size of dandruff.Standards of grading adopt ten point system, and completely to no effect, 3-4 divides DeGrain to 1-2, and 5-6 divides and produces effect, and 7-8 divides effect remarkable, and 9-10 divides effect highly significant.Various shampoo composite result of use evaluation results are listed in table 3.
The anti-dandruff effect sensory evaluation of table 3 shampoo composite
3. the application of desquamation compositions I-VII in hair conditioner
3.1 application of desquamation compositions I-VII in hair conditioner: desquamation compositions embodiment I-VII is added according to 0.2%, 1.0% percentage by weight respectively, hair conditioner matrix components is identical, by following compositions in weight percentage, formed: octadecyl trimethyl ammonium chloride 1.0%, C16/C18 mixed alcohol 2.0%, emulsified silicone oil 3.0%, glyceryl monostearate 0.3%.
The application sensory effects of 3.2 desquamation compositions I-VII in hair conditioner evaluated
Sensory evaluation method is evaluated with 2.3 dandruff control shampoo containing sense organ effects, and various hair conditioner composition result of use evaluation results are listed in table 4.
The anti-dandruff effect sensory evaluation of table 4 hair conditioner composition
It is better that described anti-dandruff hair conditioner and dandruff control shampoo containing are used in conjunction with effect, can obtain the fungistatic effect of highly significant after 2 weeks, and after 2 weeks, there is no rebound phenomena with common shampoo.
Claims (6)
1. a desquamation compositions, its feature at component and the content of compositions is: Zinc Pyrithione percentage by weight is 2.0-20.0%; Sophorolipid goods synergist percentage by weight is 5.0-15.0%; High molecular polymer suspension dispersive agent percentage by weight is 0.3-2.0%; Water is or/and alcohol weight ratio 63.0-92.7%.
2. desquamation compositions according to claim 2, the particle diameter of described anti-dandruff active component Zinc Pyrithione is 1.0-5.0 micron.
3. desquamation compositions according to claim 2, in described sophorolipid goods, sophorolipid percentage by weight is greater than 70%; Sophorolipid exists as the mixture of lactone (I) and acid (II) form, and the part that is preferably greater than 90% weight ratio is lactone (I) form.
4. desquamation compositions according to claim 2, described high molecular polymer suspending agent is elected acrylate copolymer as.
5. described in claim 5, desquamation compositions is washed the application in hair products at the anti-dandruff type shampoo of preparation, hair conditioner.
6. application according to claim 6, is characterized in that the 0.5-2.0% interpolation by weight percentage in shampoo of described desquamation compositions, at hair conditioner, is that 0.2-1.0% adds by weight percentage.
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| CN112691044A (en) * | 2019-10-22 | 2021-04-23 | 上海家化联合股份有限公司 | Positive charge modified solid lipid nanoparticle and preparation method thereof |
| CN112691044B (en) * | 2019-10-22 | 2023-10-17 | 上海家化联合股份有限公司 | Positive charge modified solid lipid nanoparticle and preparation method thereof |
| CN115362006A (en) * | 2020-03-18 | 2022-11-18 | 巴斯夫欧洲公司 | Personal care compositions, methods of using the same and improvements in deposition |
| US11906507B2 (en) | 2020-03-24 | 2024-02-20 | The Procter & Gamble Company | Methods for testing skin samples |
| CN112006954A (en) * | 2020-08-19 | 2020-12-01 | 广东柏俐臣生物科技有限公司 | Shampoo and preparation method thereof |
| CN112006954B (en) * | 2020-08-19 | 2023-03-21 | 广东柏俐臣生物科技有限公司 | Shampoo and preparation method thereof |
| EP4029871A1 (en) | 2021-01-16 | 2022-07-20 | Godrej Industries Limited | Novel antimicrobial antifungal composition |
| US11771634B2 (en) | 2021-01-16 | 2023-10-03 | Godrej Industries Limited | Antimicrobial antifungal composition |
| WO2024002825A1 (en) * | 2022-06-28 | 2024-01-04 | Basf Se | Personal care composition, method for using such compositions and its improvement of dispersibility, stability and deposition effects |
| CN115414301A (en) * | 2022-10-21 | 2022-12-02 | 广州德谷个人护理用品有限公司 | Plant anti-dandruff composition and preparation method and application thereof |
| CN115414301B (en) * | 2022-10-21 | 2024-02-27 | 广州德谷个人护理用品有限公司 | Plant anti-dandruff composition and preparation method and application thereof |
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