CN104094122B - 用于在基板上处理生物样本的盖元件、方法和处理模块 - Google Patents

用于在基板上处理生物样本的盖元件、方法和处理模块 Download PDF

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Publication number
CN104094122B
CN104094122B CN201280067038.XA CN201280067038A CN104094122B CN 104094122 B CN104094122 B CN 104094122B CN 201280067038 A CN201280067038 A CN 201280067038A CN 104094122 B CN104094122 B CN 104094122B
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substrate
cap member
fluid
sample
chamber
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Chinese (zh)
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CN104094122A (zh
Inventor
马克·布赖恩·多克里尔
安东尼·法瓦洛罗
肯尼思·衡冲·额
马丁·利蒙
彼得·图古德
斯蒂芬·约翰·巴尼亚托
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Leica Biosystems Melbourne Pty Ltd
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Leica Biosystems Melbourne Pty Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B01L2300/1866—Microwaves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201280067038.XA 2011-11-16 2012-11-15 用于在基板上处理生物样本的盖元件、方法和处理模块 Active CN104094122B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161560543P 2011-11-16 2011-11-16
US61/560,543 2011-11-16
PCT/AU2012/001407 WO2013071352A1 (en) 2011-11-16 2012-11-15 Cover member, method and treatment module for treating a biological sample on a substrate

Publications (2)

Publication Number Publication Date
CN104094122A CN104094122A (zh) 2014-10-08
CN104094122B true CN104094122B (zh) 2017-03-22

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Country Link
US (3) US10549271B2 (https=)
EP (1) EP2780721B1 (https=)
JP (2) JP2014533823A (https=)
CN (1) CN104094122B (https=)
AU (1) AU2012339616B2 (https=)
BR (1) BR112014011935B1 (https=)
CA (1) CA2855511C (https=)
IN (1) IN2014CN04294A (https=)
WO (1) WO2013071352A1 (https=)

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AU2013337611B2 (en) 2012-11-01 2017-05-04 Leica Biosystems Melbourne Pty Ltd Slide staining assembly and cover member
CN104884932A (zh) * 2012-11-01 2015-09-02 莱卡生物系统墨尔本私人有限公司 流体输送系统
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US10137450B2 (en) * 2014-07-18 2018-11-27 Tecan Trading Ag Microfluidics cartridge with pipetting guide
WO2016190111A1 (ja) 2015-05-26 2016-12-01 オリンパス株式会社 検体染色装置および検体染色方法
US9958362B1 (en) * 2015-10-02 2018-05-01 The Florida State University Research Foundation, Inc. Microscope sample preparation device
WO2018022025A1 (en) * 2016-07-26 2018-02-01 Hewlett-Packard Development Company, L.P. Microfluidic apparatuses
EP3441143B1 (en) * 2017-08-08 2022-04-13 Roche Diagnostics GmbH Laboratory instrument base plate
CN108152109B (zh) * 2017-12-14 2021-02-09 深圳达盟生物科技有限公司 载玻片盖体及其用于组织切片清洗的方法
CN108387428A (zh) * 2018-02-26 2018-08-10 深圳安诺康生物医疗有限公司 一种病理切片的染色方法
AU2019302550B2 (en) 2018-07-10 2024-05-23 Nanocytomics, LLC Automated sample deposition and staining systems and associated methods
KR102246609B1 (ko) * 2018-08-01 2021-04-30 주식회사 미코바이오메드 복수의 열 블록을 구비한 핵산 증폭 장치
WO2020124156A1 (en) * 2018-12-20 2020-06-25 Leica Biosystems Melbourne Pty Ltd A slide output module
CN112771381B (zh) * 2018-12-20 2025-10-17 莱卡生物系统墨尔本私人有限公司 散装流体清洗模块
WO2020154248A1 (en) * 2019-01-21 2020-07-30 Forward Biotech, Inc. Liquid evaluation
CN109900542A (zh) * 2019-03-15 2019-06-18 深圳市金准生物医学工程有限公司 测试卡温育的自动封闭的腔体装置
EP3969876B1 (en) * 2019-05-14 2025-08-20 Ventana Medical Systems, Inc. System including a biological sample treatment chamber and use
EP3825004A1 (en) * 2019-11-22 2021-05-26 Koninklijke Philips N.V. New multi-functional fluidic device for clamping biopsies
CN115397558B (zh) * 2020-04-24 2025-07-08 株式会社百奥尼 能够跟踪的多孔板用精密样品注入装置
CN115773920B (zh) * 2021-09-06 2024-04-19 南京泰立瑞信息科技有限公司 一种低损耗、自动化的切片样本染色方法和系统
EP4453532A4 (en) * 2021-12-23 2025-12-17 Leica Biosystems Melbourne Pty SAMPLE PROCESSING INSTRUCTIONS FOR TREATMENT OF A SAMPLE ON A SUBSTRATE
HU231596B1 (hu) * 2022-02-04 2025-03-28 3Dhistech Kft. Tárgylemez takaró eszköz, valamint inkubációs kamra, amely ilyen tárgylemez takaró eszközt tartalmaz
US20240167921A1 (en) * 2022-11-18 2024-05-23 Zomedica Inc. Methods and systems for slide treatment processing
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CN118874564B (zh) * 2024-07-10 2025-07-15 杭州跃真生物科技有限公司 一种样本反应容置装置及方法

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Also Published As

Publication number Publication date
CA2855511A1 (en) 2013-05-23
US20200188904A1 (en) 2020-06-18
AU2012339616B2 (en) 2016-04-28
US20230077728A1 (en) 2023-03-16
EP2780721A4 (en) 2015-07-01
BR112014011935B1 (pt) 2020-11-03
IN2014CN04294A (https=) 2015-09-04
WO2013071352A1 (en) 2013-05-23
AU2012339616A1 (en) 2014-06-12
JP2014533823A (ja) 2014-12-15
EP2780721B1 (en) 2017-08-16
CN104094122A (zh) 2014-10-08
CA2855511C (en) 2021-03-09
US11420200B2 (en) 2022-08-23
JP6633586B2 (ja) 2020-01-22
US10549271B2 (en) 2020-02-04
EP2780721A1 (en) 2014-09-24
US12157118B2 (en) 2024-12-03
BR112014011935A2 (pt) 2017-05-30
US20140315256A1 (en) 2014-10-23
JP2018021932A (ja) 2018-02-08

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