BR112014011935B1 - elemento de cobertura, método e módulo de tratamento para tratar uma amostra biológica sobre um substrato - Google Patents

elemento de cobertura, método e módulo de tratamento para tratar uma amostra biológica sobre um substrato Download PDF

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Publication number
BR112014011935B1
BR112014011935B1 BR112014011935-0A BR112014011935A BR112014011935B1 BR 112014011935 B1 BR112014011935 B1 BR 112014011935B1 BR 112014011935 A BR112014011935 A BR 112014011935A BR 112014011935 B1 BR112014011935 B1 BR 112014011935B1
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BR
Brazil
Prior art keywords
cover element
substrate
fluid
treatment module
reagent
Prior art date
Application number
BR112014011935-0A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112014011935A2 (pt
Inventor
Mark Brian Dockrill
Anthony Favaloro
Kenneth Heng-Chong Ng
Martin Limon
Peter Toogood
Stephen John Bagnato
Original Assignee
Leica Biosystems Melbourne Pty Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Biosystems Melbourne Pty Ltd. filed Critical Leica Biosystems Melbourne Pty Ltd.
Publication of BR112014011935A2 publication Critical patent/BR112014011935A2/pt
Publication of BR112014011935B1 publication Critical patent/BR112014011935B1/pt

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor
    • G01N1/312Apparatus therefor for samples mounted on planar substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0689Sealing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0822Slides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0851Bottom walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1861Means for temperature control using radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1861Means for temperature control using radiation
    • B01L2300/1866Microwaves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BR112014011935-0A 2011-11-16 2012-11-15 elemento de cobertura, método e módulo de tratamento para tratar uma amostra biológica sobre um substrato BR112014011935B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161560543P 2011-11-16 2011-11-16
US61/560,543 2011-11-16
PCT/AU2012/001407 WO2013071352A1 (en) 2011-11-16 2012-11-15 Cover member, method and treatment module for treating a biological sample on a substrate

Publications (2)

Publication Number Publication Date
BR112014011935A2 BR112014011935A2 (pt) 2017-05-30
BR112014011935B1 true BR112014011935B1 (pt) 2020-11-03

Family

ID=48428835

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011935-0A BR112014011935B1 (pt) 2011-11-16 2012-11-15 elemento de cobertura, método e módulo de tratamento para tratar uma amostra biológica sobre um substrato

Country Status (9)

Country Link
US (3) US10549271B2 (https=)
EP (1) EP2780721B1 (https=)
JP (2) JP2014533823A (https=)
CN (1) CN104094122B (https=)
AU (1) AU2012339616B2 (https=)
BR (1) BR112014011935B1 (https=)
CA (1) CA2855511C (https=)
IN (1) IN2014CN04294A (https=)
WO (1) WO2013071352A1 (https=)

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US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
JP2016531282A (ja) 2013-06-26 2016-10-06 アレンティック マイクロサイエンス インコーポレイテッド 顕微鏡法に関するサンプル処理の改善
EP3052609B1 (en) * 2013-10-04 2021-06-09 BioGenex Laboratories, Inc. Assembly for forming microchamber for inverted substrate
US10137450B2 (en) * 2014-07-18 2018-11-27 Tecan Trading Ag Microfluidics cartridge with pipetting guide
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CN108387428A (zh) * 2018-02-26 2018-08-10 深圳安诺康生物医疗有限公司 一种病理切片的染色方法
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WO2020124156A1 (en) * 2018-12-20 2020-06-25 Leica Biosystems Melbourne Pty Ltd A slide output module
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WO2020154248A1 (en) * 2019-01-21 2020-07-30 Forward Biotech, Inc. Liquid evaluation
CN109900542A (zh) * 2019-03-15 2019-06-18 深圳市金准生物医学工程有限公司 测试卡温育的自动封闭的腔体装置
EP3969876B1 (en) * 2019-05-14 2025-08-20 Ventana Medical Systems, Inc. System including a biological sample treatment chamber and use
EP3825004A1 (en) * 2019-11-22 2021-05-26 Koninklijke Philips N.V. New multi-functional fluidic device for clamping biopsies
CN115397558B (zh) * 2020-04-24 2025-07-08 株式会社百奥尼 能够跟踪的多孔板用精密样品注入装置
CN115773920B (zh) * 2021-09-06 2024-04-19 南京泰立瑞信息科技有限公司 一种低损耗、自动化的切片样本染色方法和系统
EP4453532A4 (en) * 2021-12-23 2025-12-17 Leica Biosystems Melbourne Pty SAMPLE PROCESSING INSTRUCTIONS FOR TREATMENT OF A SAMPLE ON A SUBSTRATE
HU231596B1 (hu) * 2022-02-04 2025-03-28 3Dhistech Kft. Tárgylemez takaró eszköz, valamint inkubációs kamra, amely ilyen tárgylemez takaró eszközt tartalmaz
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Also Published As

Publication number Publication date
CA2855511A1 (en) 2013-05-23
US20200188904A1 (en) 2020-06-18
AU2012339616B2 (en) 2016-04-28
US20230077728A1 (en) 2023-03-16
EP2780721A4 (en) 2015-07-01
IN2014CN04294A (https=) 2015-09-04
WO2013071352A1 (en) 2013-05-23
AU2012339616A1 (en) 2014-06-12
JP2014533823A (ja) 2014-12-15
EP2780721B1 (en) 2017-08-16
CN104094122B (zh) 2017-03-22
CN104094122A (zh) 2014-10-08
CA2855511C (en) 2021-03-09
US11420200B2 (en) 2022-08-23
JP6633586B2 (ja) 2020-01-22
US10549271B2 (en) 2020-02-04
EP2780721A1 (en) 2014-09-24
US12157118B2 (en) 2024-12-03
BR112014011935A2 (pt) 2017-05-30
US20140315256A1 (en) 2014-10-23
JP2018021932A (ja) 2018-02-08

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2748 DE 05-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.