CN104083617A - Method for preparing child-strengthening digestion-promoting oral solution - Google Patents
Method for preparing child-strengthening digestion-promoting oral solution Download PDFInfo
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Abstract
The invention discloses a method for preparing a child-strengthening digestion-promoting oral solution. The method comprises the following steps: decocting astragalus membranaceus, fried rhizoma atractylodis macrocephalae, dried tangerine peel, radix ophiopogonis, scutellaria baicalensis, fried hawthorn and fried radish seed with water to obtain an extract solution; filtering the extract solution through an ultrafine filter membrane to obtain a clear solution; concentrating the clear solution to obtain a clear extract; adding honey, potassium sorbate and water into the clear extract, and uniformly mixing; filtering through tubular ultrafiltration membrane equipment. According to the preparation method, an optimal method and an optimal condition for preparing the child-strengthening digestion-promoting oral solution are determined, the extract solution is effectively filtered by adopting the ultrafine filter membrane, a refrigeration process in traditional production is not needed, and the prepared medicinal liquid is subjected to final filtration by means of the tubular ultrafiltration membrane filter technology, so that the clarity of the medicinal liquid and the content of baicalin in the medicinal liquid can be remarkably increased, the product quality can be promoted, the product quality stability can be guaranteed, alcohol-free production can be realized, the production cycle can be remarkably shortened, and the energy consumption and production cost can be reduced. The method is suitable for large-scale production.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine pharmacy, particularly relate to a kind of preparation method of valiant fighter's digestion promoting oral liquid.
Background technology
Valiant fighter's digestion promoting oral liquid is the liquid preparation of Chinese medicine being prepared from by the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched), the above seven flavor medicine material of Semen Raphani (parched), there is invigorating spleen and reinforcing stomach, the effect of regulating the flow of vital energy and helping digestion, for pediatric diet, do not save the swollen abdominal distention of indigestion and loss of appetite lack of appetite, gastral cavity, feverish sensation in the palms and soles, unconsciously sweat and tire, stool that impairing the spleen and stomach causes uncomfortable, so that the diseases such as anorexia, evil food, the welcome of Guang Shou consumer.But because traditional processing technology is limit, the same with other oral preparation of Chinese traditional medicinal, in producing and storing, easily produce precipitation, be long placed in more obviously, constant product quality is poor.
In preparation technology who discloses valiant fighter's digestion promoting oral liquid of 2010 editions < < Chinese Pharmacopoeia > >, comprise that step (1) gets the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched), the above seven flavor medicine material of Semen Raphani (parched), decoct with water secondary, each 2 hours, filter, merging filtrate, filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys); Step (2) clear paste cold preservation 48 hours, filters, and filtrate adds refined honey 300g, potassium sorbate 0.67g (using suitable quantity of water thermosol), stir evenly, and standing 48 hours, get supernatant liquid filtering, water is adjusted to 1000L, embedding, sterilizing, obtains.
In this technique, adopt traditional decocting technique, in leaching process, because water is a kind of strong polar solvent, hydrophilic composition in medical material, as the not too large polysaccharide of inorganic salt, saccharide, molecule, tannin, aminoacid, protein, acylate, alkaloid salt and glycoside etc. can be gone out by water-soluble, the impurity such as a large amount of invalid starch, polysaccharide, phlegmatic temperament, resin, tannin are also extracted in the lump, and the easy mould evil idea of medicinal liquid making is rotten; Some is containing the Chinese herbal medicine of pectin, phlegmatic temperament constituents, and its aqueous extract is usually difficult to filter, during boiling water extraction, starch in medical material can also be increased the difficulty of filtering by gelatinizing, makes to increase cold preservation time of repose in actual production, production cycle is long, and production cost is high; In medical material aqueous extract, contain Saponin and phlegmatic temperament constituents, when concentrating under reduced pressure, also can produce a large amount of foams, cause concentrated difficulty, the Chinese medicine oral liquid making usually exist mouthfeel poor, place a period of time and produce a large amount of precipitations.If adopt traditional aqueous extraction-alcohol precipitation technology remove impurity, because Chinese crude drug volume is large, ethanol consumption is many, and loss is large, and cost is high, and at the bottom of boiling point, is unfavorable for safety in production, and poor stability, the cycle is long, labor intensity is large, production environment is poor.
The traditional Pulvis Talci drainage plate-and-frame filtration impurity removal and purification of general employing when valiant fighter's digestion promoting oral liquid preparing process herb liquid filters, because this filter type relies the molding situation in Pulvis Talci filter cake, when amount of talc is improper, operate when improper, Pulvis Talci filter cake will be not tight, have a strong impact on the effect of medical filtration, make medicinal liquid clarity not reach requirement, thereby need to again prepare Pulvis Talci filter cake repeats to filter to medicinal liquid, cause the operating time to extend, complex operation step, still can not guarantee product quality.
Based on this, need badly the preparation technology of existing valiant fighter's digestion promoting oral liquid is improved.
Summary of the invention
Based on this, the invention provides a kind of preparation method of valiant fighter's digestion promoting oral liquid.
The concrete technical scheme solving the problems of the technologies described above is as follows:
A preparation method for valiant fighter's digestion promoting oral liquid, the effective ingredient of described valiant fighter's digestion promoting oral liquid is prepared from by the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), and described preparation method comprises the steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) supermicro filtration membrane that is 20nm～200nm by the extracting solution via hole diameter of step (1) gained filters, and obtains clear liquid, and clear liquid is concentrated into clear paste;
Or the supermicro filtration membrane that is 20nm～200nm by the extracting solution via hole diameter of step (1) gained filtration, obtaining clear liquid, the tubular ultra-filtration membrane equipment that is 10000～200000 through molecular cut off by clear liquid filters, and obtains filtrate, and filtrate is concentrated into clear paste; The pressure that described tubular ultra-filtration membrane equipment filters is 0.1MPa～0.4MPa, and temperature is 0 ℃～40 ℃, and membrane flux is 50L/m
2h～300L/m
2h;
The pressure that described supermicro filtration membrane filters is 0.1MPa～0.4MPa, and temperature is 15 ℃～85 ℃;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 10000～200000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.1MPa～0.4MPa, and temperature is 0 ℃～40 ℃, and membrane flux is 50L/m
2h～300L/m
2h.
In some embodiment, the aperture of the described supermicro filtration membrane of step (2) is 100nm～200nm therein; The pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃.
In some embodiment, the molecular cut off of the described tubular ultra-filtration membrane of step (3) is 50000～100000 therein.
In some embodiment, the pressure that the described tubular ultra-filtration membrane equipment of step (3) filters is 0.25MPa～0.35MPa therein, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
In some embodiment, the described supermicro filtration membrane of step (2) is organic membrane, inorganic ceramic film or rustless steel tubular type film therein.
In some embodiment, the described supermicro filtration membrane of step (2) is inorganic ceramic film or rustless steel tubular type film therein.
In some embodiment, the molecular cut off of the described tubular ultra-filtration membrane of step (2) is 30000～50000 therein.
In some embodiment, the pressure that the described tubular ultra-filtration membrane equipment of step (2) filters is 0.3MPa～0.4MPa therein, and temperature is 30 ℃～35 ℃, and membrane flux is 250L/m
2h～280L/m
2h.
In some embodiment, a kind of preparation method of valiant fighter's digestion promoting oral liquid, comprises the steps: therein
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) the inorganic ceramic membrane filtration that is 100nm～200nm by the extracting solution via hole diameter of step (1) gained, obtains clear liquid, and clear liquid is concentrated into clear paste; The pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 50000～100000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.25MPa～0.35MPa, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
In some embodiment, a kind of preparation method of valiant fighter's digestion promoting oral liquid, comprises the steps: therein
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) the inorganic ceramic membrane filtration that is 100nm～200nm by the extracting solution via hole diameter of step (1) gained, obtains clear liquid, and the tubular ultra-filtration membrane equipment that is 30000～50000 through molecular cut off by clear liquid filters, and obtains filtrate, and filtrate is concentrated into clear paste; The pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃; The pressure that described tubular ultra-filtration membrane equipment filters is 0.3MPa～0.4MPa, and temperature is 30 ℃～35 ℃, and membrane flux is 250L/m
2h～280L/m
2h;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 50000～100000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.25MPa～0.35MPa, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
In some embodiment, the described clear paste of step (2) is under 58 ℃～62 ℃ conditions therein, and relative density is 1.01～1.05.
In some embodiment, the number of times of the described decoction of step (1) is 2～3 times, each 1.5～2.5 hours therein.
The preparation principle of the preparation method of valiant fighter's digestion promoting oral liquid of the present invention is as follows:
Valiant fighter's digestion promoting oral liquid preparation technology of the present invention, in pre-treatment extraction process, medical material water extraction liquid adopts inorganic ceramic film or rustless steel tubular type membrane filtration technique.Described inorganic ceramic film refers to the anisotropic membrane being prepared from as material through special technology such as aluminium oxide, zirconium oxide, titanium oxides with ceramic material, and membrane aperture specification is generally 20,50,100,200,500,800 or 1200nm; Described rustless steel tubular type film is to adopt high-tech by firm 316L powder of stainless steel lining body and TiO
2inert coatings combines, and forms a kind of separated aperture and is respectively 20nm and the nonpolar inorganic material film of 100nm, and peculiar asymmetry membrane structure, by TiO
2stratum disjunctum, small-bore supporting layer, large aperture supporting layer form.Two kinds of supermicro filtration membranes are single tube shape and multichannel tubulose structure; The tube wall micropore that gathers, under the effect of operation pressure reduction, feed liquid is cross-flow passes in film pipe, and the part that is less than membrane aperture enters per-meate side by fenestra becomes filtrate, and the material tunicle that is greater than aperture is held back and becomes concentrated solution, thereby reach separation, remove impurity and the refining object of material.
Meanwhile, adopted tubular ultra-filtration membrane equipment, overcome the shortcoming of hollow-fibre membrane, tubular ultra-filtration membrane involved in the present invention, is multichannel tubulose structure, the wall pipe micropore that gathers.Its tubular membrane has excellent intensity, antipollution, antioxidation, acid and alkali-resistance (pH1-13) performance, and pure water flux is up to 750L/m
2h, operating pressure can reach 10bar, and operating temperature can reach 80 ℃.Under stressed effect, feed liquid flows in film pipe inner side (or outside) outside, and liquid sees through film, and impurity tunicle is held back, thereby reaches separation, remove impurity and refining object.
The advantage of tubular membrane device is as follows: (1) tubular membrane material is little to the macromolecular substances absorbability in material, and performance degradation is slow.(2) tubular membrane polyester prop carrier has good ductility and the resistance to pressure pressure of the highest 0.8mpa of bearing, and tubular membrane can be born higher pressure separating effect and is better than hollow-fibre membrane.(3) the micropore runner of tubular membrane is cavernous structure, and film outside does not have cortex, is easy to the infiltration of feed liquid, and the little cleaning of resistance is easy.(4) division of tubular membrane molecular weight is meticulous, can adapt to different separation requirement.(5) tubular membrane minimum is 5 millimeters of passages, when separation, can not have clogging.(6) tubular membrane is intrinsic pressure cross-flow circulating filtration, and runner is fixed, and without dead angle, cleaning and sterilizing is thorough.
Adopt high-tech ultrafilter membrane and tubular membrane isolation technics to process Chinese traditional medicine water extract, compare with conventional alcohol deposition method, effectively remove macromole, tannin and other non-active ingredients in medicinal liquid, make the quality of product obtain significant raising, shortened the production cycle.This technology, without increasing the standing operation of cold preservation, can not need to adopt alcohol precipitation process remove impurity, realizes without alcoholization and producing, make production operation safer, alleviate the operating pressure of rear operation, shorten the production time, thereby reduce production costs, played the effect of " double gain ".
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present invention has the following advantages and beneficial effect:
The present invention is through a large amount of research of inventor and experiment, draw the best approach and the optimal parameter condition of preparation valiant fighter digestion promoting oral liquid, this preparation method is suitably effectively being filtered extracting solution with supermicro filtration membrane under aperture and specified conditions, or under specified conditions, with tubular ultra-filtration membrane, filter again after filtration, and without cold preservation operation or alcohol precipitation process in traditional mode of production, and under specified conditions, with tubular ultra-filtration membrane filtering technique, the medicinal liquid of preparing after (adding the materials such as refined honey, potassium sorbate) is carried out to end-filtration again; The method has significantly improved the content of baicalin in the clarity of medicinal liquid and medicinal liquid, has promoted product quality, has also guaranteed the quality stability of product, also can realize without alcoholization and producing, significantly shorten the production cycle, reduced energy consumption and production cost, be suitable for large-scale production.
The specific embodiment
Valiant fighter's digestion promoting oral liquid of the present invention, by 1000L, be that the raw material by following weight is prepared from, the Radix Astragali 66～67kg, Rhizoma Atractylodis Macrocephalae (parched) 33～34kg, Pericarpium Citri Reticulatae 33～34kg, Radix Ophiopogonis 66～67kg, Radix Scutellariae 33～34kg, Fructus Crataegi (parched) 33～34kg, Semen Raphani (parched) 33～34kg, refined honey 295～305kg, potassium sorbate 0.66～0.68kg and purified water (volume being adjusted to 1000L by purified water).
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) extracting solution is used to inorganic ceramic membrane filtration, the membrane aperture of described inorganic ceramic film is 200nm, and filter pressure is controlled at 0.15-0.3MPa, and temperature is controlled at 45 ℃～50 ℃, obtain filtrate, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and with tubular ultra-filtration membrane, filters, membrane aperture is molecular cut off 100000, filter pressure: 0.25～0.35MPa, filtration temperature: 20 ℃～35 ℃, membrane flux: 200～230L/m
2h, water is adjusted to 1000L, embedding, sterilizing, obtains.
Embodiment 2
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the above seven flavor medicine material of the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) extracting solution is filtered with inorganic ceramic film, membrane aperture 20nm, filter pressure is controlled at 0.1～0.2MPa, and temperature is controlled at 15 ℃～40 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stir evenly, standing 48 hours, getting supernatant filters with tubular ultra-filtration membrane, membrane aperture is molecular cut off 100000, filter pressure: 0.1～0.2MPa, filtration temperature: 5 ℃～25 ℃, membrane flux: 100～150L/m
2h, water is adjusted to 1000L, embedding, sterilizing, obtains.
Embodiment 3
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) by rustless steel tubular type membrane filtration mistake for extracting solution, the membrane aperture of described rustless steel tubular type film is 20nm, filter pressure is controlled at 0.2～0.3MPa, and temperature is controlled at 43 ℃～48 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and with tubular ultra-filtration membrane, filters, membrane aperture is molecular cut off 100000, filter pressure: 0.18～0.37MPa, filtration temperature: 20 ℃～30 ℃, membrane flux: 250～300L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Embodiment 4
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) by rustless steel tubular type membrane filtration mistake for extracting solution, membrane aperture 100nm, filter pressure is controlled at 0.1～0.2MPa, and temperature is controlled at 40 ℃～50 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and tubular ultra-filtration membrane filters, membrane aperture is molecular cut off 10000, filter pressure: 0.2～0.3MPa, filtration temperature: 30 ℃～40 ℃, membrane flux: 200～250L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Embodiment 5
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) by rustless steel tubular type membrane filtration mistake for extracting solution, the membrane aperture 100nm of described inorganic ceramic film, filter pressure is controlled at 0.2～0.4MPa, and temperature is controlled at 45 ℃～55 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and tubular ultra-filtration membrane filters, membrane aperture is molecular cut off 10000, filter pressure: 0.1～0.2MPa, filtration temperature: 10 ℃～25 ℃, membrane flux: 100～150L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Embodiment 6
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) by rustless steel tubular type membrane filtration mistake for extracting solution, membrane aperture 100nm, filter pressure is controlled at 0.1～0.2MPa, and temperature is controlled at 55 ℃～65 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys).
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water 400L, stirs evenly, and tubular ultra-filtration membrane filters, membrane aperture is molecular cut off 50000, filter pressure: 0.2～0.25MPa, filtration temperature: 30 ℃～35 ℃, membrane flux: 250～280L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Embodiment 7
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) by rustless steel tubular type membrane filtration mistake for extracting solution, membrane aperture 100nm, filter pressure is controlled at 0.2～0.3MPa, and temperature is controlled at 65 ℃～85 ℃, and filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and tubular ultra-filtration membrane filters, membrane aperture is molecular cut off 200000, filter pressure: 0.3～0.4MPa, filtration temperature: 30 ℃～40 ℃, membrane flux: 150～200L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Embodiment 8
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and stir-fry Semen Raphani seven flavor medicine material altogether, decoct with water 2 times, each 2 hours, obtain extracting solution;
(2) extracting solution is filtered with inorganic ceramic film, membrane aperture 200nm, filter pressure is controlled at 0.15～0.3MPa, and temperature is controlled at 45 ℃～50 ℃, obtains clear liquid; Clear liquid is filtered with tubular ultra-filtration membrane equipment, and membrane aperture molecular cut off is 50000, filter pressure: 0.3～0.4MPa, and filtration temperature: 30 ℃～35 ℃, membrane flux: 250～280L/m
2h, filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(3) clear paste adds refined honey, potassium sorbate (using suitable quantity of water thermosol) and purified water, stirs evenly, and with tubular ultra-filtration membrane, filters, membrane aperture molecular cut off is 100000, filter pressure: 0.25～0.35MPa, filtration temperature: 20 ℃～35 ℃, membrane flux: 200～230L/m
2h water is adjusted to 1000L, embedding, and sterilizing, obtains.
Comparative example 1 traditional handicraft
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the above seven flavor medicine material of the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water 2 times, each 2 hours, filter, merging filtrate, filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(2) clear paste cold preservation is 48 hours, filters, and filtrate adds refined honey, potassium sorbate (using suitable quantity of water thermosol), stir evenly, and standing 48 hours, get supernatant liquid filtering, by purified water, be adjusted to 1000L, embedding, sterilizing, obtains.
Comparative example 2 aqueous extraction-alcohol precipitation technologies
The preparation method of a kind of valiant fighter's digestion promoting oral liquid of the present embodiment, comprises the following steps:
(1) get the above seven flavor medicine material of the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water secondary, each 2 hours, filter, filtrate is concentrated into relative density 1.25 (80 ℃), add ethanol 7000ml, stir evenly, standing over night, get supernatant, filter, merging filtrate, filtrate is concentrated into the clear paste that relative density is 1.01～1.05 (60 ℃ of surveys);
(2) clear paste cold preservation is 48 hours, filters, and filtrate adds refined honey, potassium sorbate (using suitable quantity of water thermosol), stir evenly, and standing 48 hours, get supernatant liquid filtering, water is adjusted to 1000L, embedding, sterilizing, obtains.
Test example 1
One, experiment purpose
The quality of the valiant fighter's digestion promoting oral liquid making by preparation method described in relative analysis Evaluation operation example 1, embodiment 2, embodiment 3, embodiment 5 and embodiment 8.
Two, experimental technique
Get 3 batch samples that make according to preparation method described in embodiment 1, embodiment 2, embodiment 3, embodiment 5 and embodiment 8 and 3 batch samples that make according to comparative example 1 traditional handicraft and comparative example 2 water extract-alcohol precipitation methods and carry out quality contrast (detecting according to 2010 editions Chinese Pharmacopoeia valiant fighter digestion promoting oral liquid quality standards).
Three, experimental result
Result is referring to table 1, as known from Table 1: the clarity of oral liquid that embodiment 1, embodiment 2, embodiment 3, embodiment 5 and embodiment 8 make is high, and quality stability is also higher, and in medicinal liquid, the content of baicalin is significantly improved, with short production cycle.
The quality comparative result table of table 1 embodiment and the prepared oral liquid of comparative example
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a preparation method for valiant fighter's digestion promoting oral liquid, the effective ingredient of described valiant fighter's digestion promoting oral liquid is prepared from by the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), it is characterized in that, and described preparation method comprises the steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) supermicro filtration membrane that is 20nm～200nm by the extracting solution via hole diameter of step (1) gained filters, and obtains clear liquid, and clear liquid is concentrated into clear paste;
Or the supermicro filtration membrane that is 20nm～200nm by the extracting solution via hole diameter of step (1) gained filtration, obtaining clear liquid, the tubular ultra-filtration membrane equipment that is 10000～200000 through molecular cut off by clear liquid filters, and obtains filtrate, and filtrate is concentrated into clear paste; The pressure that described tubular ultra-filtration membrane equipment filters is 0.1MPa～0.4MPa, and temperature is 0 ℃～40 ℃, and membrane flux is 50L/m
2h～300L/m
2h;
The pressure that described supermicro filtration membrane filters is 0.1MPa～0.4MPa, and temperature is 15 ℃～85 ℃;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 10000～200000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.1MPa～0.4MPa, and temperature is 0 ℃～40 ℃, and membrane flux is 50L/m
2h～300L/m
2h.
2. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1, it is characterized in that, described in step (2), the aperture of supermicro filtration membrane is 100nm～200nm, and the pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃.
3. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1 and 2, is characterized in that, the molecular cut off of the described tubular ultra-filtration membrane of step (3) is 50000～100000.
4. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1 and 2, is characterized in that, the pressure that the described tubular ultra-filtration membrane equipment of step (3) filters is 0.25MPa～0.35MPa, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
5. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1 and 2, is characterized in that, the described supermicro filtration membrane of step (2) is inorganic ceramic film or rustless steel tubular type film.
6. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1 and 2, is characterized in that, the molecular cut off of the described tubular ultra-filtration membrane of step (2) is 30000～50000.
7. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1 and 2, is characterized in that, the pressure that the described tubular ultra-filtration membrane equipment of step (2) filters is 0.3MPa～0.4MPa, and temperature is 30 ℃～35 ℃, and membrane flux is 250L/m
2h～280L/m
2h.
8. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1, is characterized in that, comprises the steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) the inorganic ceramic membrane filtration that is 100nm～200nm by the extracting solution via hole diameter of step (1) gained, obtains clear liquid, and clear liquid is concentrated into clear paste; The pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 50000～100000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.25MPa～0.35MPa, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
9. the preparation method of valiant fighter's digestion promoting oral liquid according to claim 1, is characterized in that, comprises the steps:
(1) get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Pericarpium Citri Reticulatae, Radix Ophiopogonis, Radix Scutellariae, Fructus Crataegi (parched) and Semen Raphani (parched), decoct with water, obtain extracting solution;
(2) the inorganic ceramic membrane filtration that is 100nm～200nm by the extracting solution via hole diameter of step (1) gained, obtains clear liquid, and the tubular ultra-filtration membrane equipment that is 30000～50000 through molecular cut off by clear liquid filters, and obtains filtrate, and filtrate is concentrated into clear paste; The pressure that described supermicro filtration membrane filters is 0.15MPa～0.3MPa, and temperature is 45 ℃～50 ℃; The pressure that described tubular ultra-filtration membrane equipment filters is 0.3MPa～0.4MPa, and temperature is 30 ℃～35 ℃, and membrane flux is 250L/m
2h～280L/m
2h;
(3) in the clear paste of step (2) gained, add refined honey, potassium sorbate and purified water, mix, the tubular ultra-filtration membrane equipment that is 50000～100000 through molecular cut off filters; The pressure that described tubular ultra-filtration membrane equipment filters is 0.25MPa～0.35MPa, and temperature is 20 ℃～35 ℃, and membrane flux is 200L/m
2h～230L/m
2h.
10. according to the preparation method of the valiant fighter's digestion promoting oral liquid described in claim 1,2,8 or 9, it is characterized in that, the described clear paste of step (2) is under 58 ℃～62 ℃ conditions, and relative density is 1.01～1.05.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887943A (en) * | 2015-06-15 | 2015-09-09 | 吉林万通药业集团梅河药业股份有限公司 | Children strengthening and digestion promoting oral solution and preparation method thereof |
| CN108607017A (en) * | 2018-06-08 | 2018-10-02 | 辽宁仙草堂药业有限公司 | A kind of preparation method of ZAOREN ANSHEN YE |
| CN111035715A (en) * | 2020-01-06 | 2020-04-21 | 广东利泰制药股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal function and regulating intestinal flora |
| CN113398204A (en) * | 2020-12-25 | 2021-09-17 | 江中药业股份有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
| CN115475210A (en) * | 2022-09-16 | 2022-12-16 | 北京亚东生物制药有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
| CN115869373A (en) * | 2022-12-30 | 2023-03-31 | 江中药业股份有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
-
2014
- 2014-07-30 CN CN201410369722.4A patent/CN104083617A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887943A (en) * | 2015-06-15 | 2015-09-09 | 吉林万通药业集团梅河药业股份有限公司 | Children strengthening and digestion promoting oral solution and preparation method thereof |
| CN108607017A (en) * | 2018-06-08 | 2018-10-02 | 辽宁仙草堂药业有限公司 | A kind of preparation method of ZAOREN ANSHEN YE |
| CN111035715A (en) * | 2020-01-06 | 2020-04-21 | 广东利泰制药股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal function and regulating intestinal flora |
| CN113398204A (en) * | 2020-12-25 | 2021-09-17 | 江中药业股份有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
| CN115475210A (en) * | 2022-09-16 | 2022-12-16 | 北京亚东生物制药有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
| CN115869373A (en) * | 2022-12-30 | 2023-03-31 | 江中药业股份有限公司 | Children-strengthening digestion-promoting oral liquid and preparation method thereof |
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Application publication date: 20141008 |