CN104081105B - 密封式微流体导管组合件及其制作方法 - Google Patents

密封式微流体导管组合件及其制作方法 Download PDF

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Publication number
CN104081105B
CN104081105B CN201280067000.2A CN201280067000A CN104081105B CN 104081105 B CN104081105 B CN 104081105B CN 201280067000 A CN201280067000 A CN 201280067000A CN 104081105 B CN104081105 B CN 104081105B
Authority
CN
China
Prior art keywords
conduit
axle head
joint
extensible material
material layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280067000.2A
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English (en)
Chinese (zh)
Other versions
CN104081105A (zh
Inventor
史蒂文·爱德华·霍布斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
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DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CN104081105A publication Critical patent/CN104081105A/zh
Application granted granted Critical
Publication of CN104081105B publication Critical patent/CN104081105B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L13/00—Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints
    • F16L13/14—Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints made by plastically deforming the material of the pipe, e.g. by flanging, rolling
    • F16L13/141—Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints made by plastically deforming the material of the pipe, e.g. by flanging, rolling by crimping or rolling from the outside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17D—PIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00—Pipe-line systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G01N30/6039—Construction of the column joining multiple columns in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B29C65/562—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits using extra joining elements, i.e. which are not integral with the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B29C66/1142—Single butt to butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/12—Joint cross-sections combining only two joint-segments; Tongue and groove joints; Tenon and mortise joints; Stepped joint cross-sections
    • B29C66/122—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section
    • B29C66/1222—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section comprising at least a lapped joint-segment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/12—Joint cross-sections combining only two joint-segments; Tongue and groove joints; Tenon and mortise joints; Stepped joint cross-sections
    • B29C66/122—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section
    • B29C66/1224—Joint cross-sections combining only two joint-segments, i.e. one of the parts to be joined comprising only two joint-segments in the joint cross-section comprising at least a butt joint-segment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5221—Joining tubular articles for forming coaxial connections, i.e. the tubular articles to be joined forming a zero angle relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5229—Joining tubular articles involving the use of a socket
    • B29C66/52295—Joining tubular articles involving the use of a socket said socket comprising reinforcements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/52—Joining tubular articles, bars or profiled elements
    • B29C66/522—Joining tubular articles
    • B29C66/5229—Joining tubular articles involving the use of a socket
    • B29C66/52298—Joining tubular articles involving the use of a socket said socket being composed by several elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/735—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the extensive physical properties of the parts to be joined
    • B29C66/7352—Thickness, e.g. very thin
    • B29C66/73521—Thickness, e.g. very thin of different thickness, i.e. the thickness of one of the parts to be joined being different from the thickness of the other part
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8158—With indicator, register, recorder, alarm or inspection means
    • Y10T137/8326—Fluid pressure responsive indicator, recorder or alarm
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y10T156/1052—Methods of surface bonding and/or assembly therefor with cutting, punching, tearing or severing
    • Y10T156/108—Flash, trim or excess removal

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)
  • Non-Disconnectible Joints And Screw-Threaded Joints (AREA)
  • Rigid Pipes And Flexible Pipes (AREA)
CN201280067000.2A 2011-11-18 2012-11-16 密封式微流体导管组合件及其制作方法 Expired - Fee Related CN104081105B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/299,506 2011-11-18
US13/299,506 US8727231B2 (en) 2011-11-18 2011-11-18 Sealed microfluidic conduit assemblies and methods for fabricating them
PCT/IB2012/002385 WO2013072755A1 (en) 2011-11-18 2012-11-16 Sealed microfluidic conduit assemblies and methods for fabricating them

Publications (2)

Publication Number Publication Date
CN104081105A CN104081105A (zh) 2014-10-01
CN104081105B true CN104081105B (zh) 2016-08-17

Family

ID=48425643

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280067000.2A Expired - Fee Related CN104081105B (zh) 2011-11-18 2012-11-16 密封式微流体导管组合件及其制作方法

Country Status (5)

Country Link
US (1) US8727231B2 (enExample)
EP (1) EP2780622A4 (enExample)
JP (1) JP6054983B2 (enExample)
CN (1) CN104081105B (enExample)
WO (1) WO2013072755A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2747860B1 (en) 2011-08-26 2020-06-17 Waters Technologies Corporation Liquid chromatography conduit assemblies having high pressure seals
US9664598B2 (en) * 2013-10-18 2017-05-30 Agilent Technologies, Inc. Microfluidic contaminant trap for trapping contaminants in gas chromatography
WO2018067304A1 (en) * 2016-10-05 2018-04-12 Waters Technologies Corporation Fluidic fitting with integral face seal
US10386344B2 (en) 2017-06-12 2019-08-20 Waters Technologies Corporation Strain induced face seal
EP3649668A4 (en) * 2017-07-07 2021-03-31 DH Technologies Development Pte. Ltd. ELEKTROSPRAY INTERFACE DEVICE AND ASSOCIATED PROCEDURES
SG11202005234XA (en) * 2018-01-29 2020-07-29 Ion Opticks Res Pty Ltd Capillary fitting
CN112118912A (zh) * 2018-03-01 2020-12-22 Dh科技发展私人贸易有限公司 集成电喷射发射器及其制造方法
FR3093463B1 (fr) * 2019-03-08 2021-07-23 Etancheite Et Frottement J Massot Procédé et dispositif de fabrication d’un objet comprenant une partie en polymère
PL445830A1 (pl) * 2023-08-14 2025-02-17 Rapa S.Międlar W. I I.Szymańscy Spółka Jawna Połączenie kapilary miedzianej z kapilarą wykonaną z tworzywa sztucznego

Citations (7)

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WO1990002902A1 (en) * 1988-09-07 1990-03-22 Ab Kinds Produkter A device and a method of providing a joint between two components and the use of such a joint
US4981586A (en) * 1980-10-29 1991-01-01 Proprietary Technology, Inc. Swivelable quick connector assembly
CN1194684A (zh) * 1996-06-10 1998-09-30 和记公司 压力流体管道使用的快速连接装置
US6022054A (en) * 1998-03-20 2000-02-08 Ameron International Corporation Thin wall fiberglass pipe connectors
US6319476B1 (en) * 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6481648B1 (en) * 1999-10-01 2002-11-19 Agilent Technologies, Inc. Spray tip for a microfluidic laboratory microchip
US20100000927A1 (en) * 2005-07-19 2010-01-07 Bertram Beigel Fluid Conduits With Molded Plastic Part

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US4529230A (en) * 1982-02-26 1985-07-16 Supelco, Inc. Capillary tubing and small rod connector
JPS6383487A (ja) * 1986-09-22 1988-04-14 日本鋼管株式会社 管継手
JPS63115686U (enExample) * 1987-01-21 1988-07-26
FR2749639B1 (fr) * 1996-06-10 1998-08-21 Hutchinson Dispositif de raccord rapide pour conduit de fluide sous pression
JP4193191B2 (ja) * 1998-03-16 2008-12-10 アクトロニクス株式会社 流体移送用極細管の接続構造
US20020189947A1 (en) 2001-06-13 2002-12-19 Eksigent Technologies Llp Electroosmotic flow controller
US7050660B2 (en) 2003-04-07 2006-05-23 Eksigent Technologies Llc Microfluidic detection device having reduced dispersion and method for making same
JP5148267B2 (ja) 2004-04-02 2013-02-20 エービー サイエックス エルエルシー 微小溶液の接続
US20070138076A1 (en) * 2005-12-16 2007-06-21 Fluidigm Corporation Devices and methods for microfluidic chromatography
JP2008075809A (ja) * 2006-09-22 2008-04-03 Sanei Kogyo Kk ロードヒーティングの配管接続構造、それに用いる防蝕スリーブおよびそれによる接続方法
DE102007031678A1 (de) 2007-07-06 2009-01-08 Thermo Fisher Scientific (Bremen) Gmbh Vorrichtung mit einer Verbindung zweier Kapillaren
JP2011508890A (ja) * 2008-01-02 2011-03-17 ウオーターズ・テクノロジーズ・コーポレイシヨン 高圧シールを有する液体クロマトグラフィ導管アセンブリ
US8794676B2 (en) * 2008-05-30 2014-08-05 Waters Technologies Corporation Device and method for connecting fluid conduits

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981586A (en) * 1980-10-29 1991-01-01 Proprietary Technology, Inc. Swivelable quick connector assembly
WO1990002902A1 (en) * 1988-09-07 1990-03-22 Ab Kinds Produkter A device and a method of providing a joint between two components and the use of such a joint
CN1194684A (zh) * 1996-06-10 1998-09-30 和记公司 压力流体管道使用的快速连接装置
US6022054A (en) * 1998-03-20 2000-02-08 Ameron International Corporation Thin wall fiberglass pipe connectors
US6319476B1 (en) * 1999-03-02 2001-11-20 Perseptive Biosystems, Inc. Microfluidic connector
US6481648B1 (en) * 1999-10-01 2002-11-19 Agilent Technologies, Inc. Spray tip for a microfluidic laboratory microchip
US20100000927A1 (en) * 2005-07-19 2010-01-07 Bertram Beigel Fluid Conduits With Molded Plastic Part

Also Published As

Publication number Publication date
JP6054983B2 (ja) 2016-12-27
US8727231B2 (en) 2014-05-20
EP2780622A1 (en) 2014-09-24
CN104081105A (zh) 2014-10-01
US20130126021A1 (en) 2013-05-23
EP2780622A4 (en) 2015-12-02
WO2013072755A1 (en) 2013-05-23
JP2015505939A (ja) 2015-02-26

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Granted publication date: 20160817