CN104069176A - Oral adhesive powder and preparation method thereof - Google Patents
Oral adhesive powder and preparation method thereof Download PDFInfo
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- CN104069176A CN104069176A CN201410107224.2A CN201410107224A CN104069176A CN 104069176 A CN104069176 A CN 104069176A CN 201410107224 A CN201410107224 A CN 201410107224A CN 104069176 A CN104069176 A CN 104069176A
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- adhesive powder
- carbomer
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Abstract
The invention provides oral adhesive powder. The powder is prepared from lonicera japonica extract, scullcap extract, CMC-Na (sodium carboxymethylcellulose), carbomer, montmorillonite, borneol, menthol and mannitol. Compared with other powdered preparations, the oral adhesive powder has the advantages that, due to the strong adhesion, the drug acting time is longer, the administration time interval is long, the frequency of drug administration is reduced, the course of treatment can be shortened, and the curative effect can be improved; the time of fasting for solids and liquids is shortened, so that the oral adhesive powder is more suitable for infants.
Description
Technical field
The present invention relates to a kind of new pharmaceutical dosage form-oral cavity sticks loose.
Background technology
Oral ulcer is a kind of common disease of cari oris mucosa, has the course of disease long, is difficult to the features such as healing, and epiphytotics survey data shows that the sickness rate of oral ulcer is about 20%, and number of patients is huge.At present oral ulcer, can topical application antiinflammatory, infection, antiviral, sterilization, wound healing promoting and strengthen the Drug therapys such as Immunoresistance.
Aspect the treatment of oral ulcer part, present herbal treatment often adopts powder, and curative effect is often not good.Because current powder exists following shortcoming: 1. it is slow to dissolve absorption, making the medicine of ulcer surface washed away by the self-cleaning power of saliva can not timely and effective covering and affect drug effect.2. viscosity for want of, tongue is involuntary lick under, make medicine effectively cover the time shorten of ulcer surface.3. need dip with cotton swab medication inconvenience when existing part powder medication.4. part powder mobility is poor, easily stops up spout, and impact is used.5. easily cause to choke and cough.
Summary of the invention
The present invention is in order to overcome the deficiencies in the prior art, provides that a kind of adhesion is stronger, drug treating time pharmaceutical dosage form-oral cavity longer, better efficacy is sticked loose for the defect of prior art.
Technical scheme of the present invention is: a kind of oral cavity is sticked loose, and the mass distribution ratio of its each component is as follows:
Flos Lonicerae extract 22g
Radix Scutellariae extract 10g
CMC-Na:10g
Carbomer: 10g
Montmorillonitum: 10g
Borneolum Syntheticum: 4g
Mentholum: 4g
Mannitol: 30g
Loose preparation method is sticked in oral cavity of the present invention, comprises the steps:
Step 1, by Flos Lonicerae extract, Radix Scutellariae extract, CMC-Na, Montmorillonitum porphyrize respectively, cross 120 mesh sieves for subsequent use;
Step 2, Borneolum Syntheticum, Mentholum are put in mortar and are ground into liquefaction, add the Flos Lonicerae extract of porphyrize and Radix Scutellariae extract to mix and grind well, and then add Montmorillonitum respectively, CMC-Na, carbomer, mannitol mix and grind well;
The mixture that step 3 makes step 2 is inserted 50 DEG C of baking 2h of baking oven;
Step 4 is crossed 120 mesh sieves by the gains porphyrize of step 3 and is packed spray bottle into.
In the present invention, the effectiveness of each medicine is as follows:
CMC-Na has thickening, emulsifying, suspension, water conservation, enhancing toughness, the several functions such as expanded and fresh-keeping, can increase drug treating time.Can also improve mouthfeel, improve class and the quality of product, and can extend the shelf life.
Carbomer has permanent stability in the time of high viscosity, makes medicine linearity, slowly discharges, and saves cost, increases the bioavailability of medicine, and energy and cellulose and other component compatibility well.
Montmorillonitum has fixing and inhibitory action to the toxin of virus, pathogenic bacteria and generation thereof; Mucosa is had to covering power, and by mutually combining with mucous glycoprotein, repair and the defense function of raising mucosa to virulence factor.Strengthen the adhesion of medicine.
Mannitol is because dissolving time heat absorption, pleasantly sweet, and there is to comfort sense in oral cavity, increases patient's compliance.
Borneolum Syntheticum has reducing swelling and alleviating pain, and antibacterial, antiinflammatory action has medicine auxiliary dual-purpose.
That Mentholum has is antipruritic, pain relieving, anticorrosion, stimulation, anesthesia, refrigerant and antiinflammatory action, has medicine auxiliary dual-purpose.
The invention has the beneficial effects as follows: the loose powder comparison with other is sticked in oral cavity of the present invention: because adhesiveness is strong, drug treating time is longer, and the medication interval time is long, and medication number of times is reduced, and can Shorten the Treatment Process, raising curative effect.Shorten fasting and prohibit the water time, be more applicable to infant and use.
Detailed description of the invention
The result of with the form of list, other powder and powder of the present invention being carried out to control experiment is below as follows:
Table 1. sticks the comparison of the bioadhesion in vitro of loose and other powder
The present invention is obviously better than other powder on adhesion as can be seen from Table 1, this be mainly we added CMC-Na and carbomer with thickening, emulsifying, enhancing toughness, to improve viscosity relevant.
Table 2. sticks the comparison of the interior adhesion time of body of loose and other powder
| ? | BINGPENG SAN | KUIYANG SAN | Watermelon crystal | Stick loose |
| Time (min) | 3±0.3 | 2±0.2 | 3±0.3 | 26±0.4 |
The present invention is obviously better than other powder on the oral cavity adhesion time as can be seen from Table 2, and this is mainly that we have added CMC-Na and carbomer to improve adhesion time.
Table 3. sticks the comparison of the action effect of loose and other powder
The present invention is obviously better than other powder in medication effect as can be seen from Table 3, and this is mainly that adhesiveness is strong, and drug treating time is longer, and medication effect on the same day just clearly, is almost recovered after 3 days.
As can be seen here, the present invention has significant effect for treatment oral ulcer.
The present invention includes but be not limited in above embodiment, the principal agent that it also can select other characteristics and above-mentioned adjuvant to adapt, the proportion relation of its each component also can carry out necessary adjustment as required.
Claims (2)
1. an oral cavity is sticked loosely, and the mass distribution ratio of its each component is as follows:
Flos Lonicerae extract 22g
Radix Scutellariae extract 10g
CMC-Na:10g
Carbomer: 10g
Montmorillonitum: 10g
Borneolum Syntheticum: 4g
Mentholum: 4g
Mannitol: 30g.
2. loose preparation method is sticked in oral cavity, comprises the steps: step 1, Flos Lonicerae extract, Radix Scutellariae extract, CMC-Na, Montmorillonitum are distinguished to porphyrize, crosses 120 mesh sieves for subsequent use; Step 2, Borneolum Syntheticum, Mentholum are put in mortar and are ground into liquefaction, add the Flos Lonicerae extract of porphyrize and Radix Scutellariae extract to mix and grind well, and then add Montmorillonitum respectively, CMC-Na, carbomer, mannitol mix and grind well; The mixture that step 3 makes step 2 is inserted 50 DEG C of baking 2h of baking oven; Step 4 is crossed 120 mesh sieves by the gains porphyrize of step 3 and is packed spray bottle into.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410107224.2A CN104069176B (en) | 2014-03-21 | 2014-03-21 | Stick scattered and preparation method thereof in a kind of oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410107224.2A CN104069176B (en) | 2014-03-21 | 2014-03-21 | Stick scattered and preparation method thereof in a kind of oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104069176A true CN104069176A (en) | 2014-10-01 |
| CN104069176B CN104069176B (en) | 2017-10-13 |
Family
ID=51591042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410107224.2A Expired - Fee Related CN104069176B (en) | 2014-03-21 | 2014-03-21 | Stick scattered and preparation method thereof in a kind of oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104069176B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619426A (en) * | 2015-11-03 | 2017-05-10 | 安国市聚药堂药业有限公司 | Chinese herbal medicine toothpaste and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857426A (en) * | 2006-03-23 | 2006-11-08 | 武汉药谷科技开发有限公司 | Medicine for treating stomatocase and laryngopharyngitis |
-
2014
- 2014-03-21 CN CN201410107224.2A patent/CN104069176B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857426A (en) * | 2006-03-23 | 2006-11-08 | 武汉药谷科技开发有限公司 | Medicine for treating stomatocase and laryngopharyngitis |
Non-Patent Citations (2)
| Title |
|---|
| 李钧: "《药用辅料及其管理》", 31 August 2009, 化学工业出版社 * |
| 汪剑新: "蒙脱石散联合开喉剑治疗小儿口腔溃疡的疗效观察", 《中国现代药物应用》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619426A (en) * | 2015-11-03 | 2017-05-10 | 安国市聚药堂药业有限公司 | Chinese herbal medicine toothpaste and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN104069176B (en) | 2017-10-13 |
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Granted publication date: 20171013 Termination date: 20180321 |
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