CN104069127A - Composition containing electrolyte balance salt and bromogeramine and preparation method thereof - Google Patents
Composition containing electrolyte balance salt and bromogeramine and preparation method thereof Download PDFInfo
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- CN104069127A CN104069127A CN201410284959.2A CN201410284959A CN104069127A CN 104069127 A CN104069127 A CN 104069127A CN 201410284959 A CN201410284959 A CN 201410284959A CN 104069127 A CN104069127 A CN 104069127A
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Abstract
The invention relates to a disinfectant composition containing electrolyte balance salt and bromogeramine, which is characterized in that the bromogeramine solution is added with the electrolyte containing sodium, potassium, calcium, magnesium salts or any combination thereof, and is used for local bacterial infection of human bodies. The composition can supplement electrolyte balance salt while sterilizing and preventing bacteria, prevents dehydration, and can rapidly recover normal physiological function.
Description
Technical field
The present invention relates to a kind of antiseptic composition that contains electrolytical balanced salt and bromo geramine.
Background technology
Bromo geramine claims again benzalkonium bromide, belongs to quaternaries cation surface active disinfectant, has the characteristics such as stable in properties, penetration is strong, zest is little, toxicity is low, tool is stronger fungicidal effectiveness, is widely used in the sterilization in skin, mucosa He Shu district.
Bromogeramine solution is colourless or flaxen clear liquid; Fragrance, taste is extremely bitter.Can change antibacterial endochylema membrane permeability, make thalline endochylema extravasation, hinder its metabolism and a killing action.Stronger to gram-positive bacteria effect, bromo geramine aqueous solution is for local skin and mucosa sterilization; Wound surface and vaginadouche.Low concentration has bacteriostasis, and high concentration has bactericidal action.
After skin injury there is inflammatory reaction in wound tissue, local telangiectasis, and tube wall permeability increases, and in blood plasma, the Multiple components such as leukocyte and antibody oozes out, sterile-processed in time on the one hand, prevents from causing traumatic infection.Because electrolyte balance is damaged, easily cause electrolytical loss and cell dehydration on the other hand, when serious, can cause shock, the electrolyte supplement balanced salt that meets a crying need.
Summary of the invention
The invention provides a kind of antiseptic composition that contains electrolytical balanced salt and bromo geramine, to overcome the deficiency of existing bromogeramine solution, when sterilization is antibacterial, electrolyte supplement balanced salt, prevents dehydration, fast quick-recovery normal physiological function.
Technical characterictic of the present invention is to have added in bromogeramine solution the electrolyte that contains sodium, potassium, calcium, magnesium salt or above combination in any wherein, for preventing electrolytical loss.
Bromo geramine can be selected bromo geramine or geramine or above combination in any wherein, preferably bromo geramine.Preferred concentration is 0.01-3%(W/V).
Electrolyte sodium salt is sodium chloride or sodium phosphate or sodium dihydrogen phosphate or sodium hydrogen phosphate or sodium acetate or sodium lactate or gluconic acid sodium salt or sodium citrate or above combination in any wherein.Preferably sodium chloride or sodium acetate or gluconic acid sodium salt or sodium citrate or above combination in any wherein.Preferred concentration is 0.1-5%(W/V).
Electrolyte potassium salt is potassium chloride or potassium dihydrogen phosphate or dipotassium hydrogen phosphate or above combination in any wherein.Preferably potassium chloride or potassium dihydrogen phosphate or both combination in any.Preferred concentration is 0.01-2%(W/V).
Electrolyte calcium salt is calcium chloride or calcium carbonate or both combination in any.Preferred concentration is 0.01-2%(W/V).
Electrolyte magnesium salt is magnesium chloride or magnesium sulfate or both combination in any.Preferred concentration is 0.01-2%(W/V).
Detailed description of the invention
Following examples are only further detailed the present invention, should not be construed as the present invention is further limited.
embodiment 1the disinfectant preparation that contains electrolyte balance salt and bromo geramine
Get purified water 1000ml, add bromo geramine 0.1g, be fully stirred to dissolve, add successively sodium chloride 5.26g, sodium acetate 3.68g, gluconic acid sodium salt 5.02g, potassium chloride 0.37g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 2the disinfectant preparation that contains electrolyte balance salt and geramine
Get purified water 1000ml, add geramine 0.1g, be fully stirred to dissolve, add successively sodium chloride 5.26g, sodium acetate 3.68g, gluconic acid sodium salt 5.02g, potassium chloride 0.37g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 3the disinfectant preparation that contains electrolyte balance salt and bromo geramine
Get purified water 1000ml, add bromo geramine 0.1g, be fully stirred to dissolve, add successively sodium chloride 6.40g, sodium acetate 3.90g, sodium citrate 1.70g, potassium chloride 0.75g, calcium chloride 0.48g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 4the disinfectant preparation that contains electrolyte balance salt and geramine
Get purified water 1000ml, add geramine 0.1g, be fully stirred to dissolve, add successively sodium chloride 6.40g, sodium acetate 3.90g, sodium citrate 1.70g, potassium chloride 0.75g, calcium chloride 0.48g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 5the disinfectant preparation that contains electrolyte balance salt and bromo geramine
Get purified water 1000ml, add bromo geramine 0.5g, be fully stirred to dissolve, add successively sodium chloride 6.40g, sodium acetate 3.90g, sodium citrate 1.70g, potassium chloride 0.75g, calcium chloride 0.48g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 6the disinfectant preparation that contains electrolyte balance salt and bromo geramine
Get purified water 1000ml, add bromo geramine 0.5g, be fully stirred to dissolve, add successively sodium chloride 5.26g, sodium acetate 3.68g, gluconic acid sodium salt 5.02g, potassium chloride 0.37g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 7the disinfectant preparation that contains electrolyte balance salt and geramine
Get purified water 1000ml, add geramine 0.5g, be fully stirred to dissolve, add successively sodium chloride 6.40g, sodium acetate 3.90g, sodium citrate 1.70g, potassium chloride 0.75g, calcium chloride 0.48g and magnesium chloride 0.30g, be fully stirred to dissolve.
embodiment 8the disinfectant preparation that contains electrolyte balance salt and geramine
Get purified water 1000ml, add geramine 0.5g, be fully stirred to dissolve, add successively sodium chloride 5.26g, sodium acetate 3.68g, gluconic acid sodium salt 5.02g, potassium chloride 0.37g and magnesium chloride 0.30g, be fully stirred to dissolve.
Claims (8)
1. a sterilizing liquid composite, said composition contains:
0.01-3%(W/V) bromo geramine or geramine and
0.01-15%(W/V) electrolyte solution.
2. compositions described in claim 1, said composition contains:
0.01-1%(W/V) bromo geramine or geramine and
0.1-5%(W/V) sodium salt,
0.01-2%(W/V) potassium salt,
0.01-2%(W/V) calcium salt,
0.01-2%(W/V) magnesium salt,
Or the combination in any of above-mentioned sodium salt, potassium salt, calcium salt, magnesium salt.
3. compositions described in claim 1 or 2, said composition contains bromo geramine or geramine or both combination in any.
4. compositions described in claim 1 or 2, said composition contains sodium chloride or sodium phosphate or sodium dihydrogen phosphate or sodium hydrogen phosphate or sodium acetate or sodium lactate or gluconic acid sodium salt or sodium citrate or above combination in any wherein.
5. compositions described in claim 1 or 2, said composition contains potassium chloride or potassium dihydrogen phosphate or dipotassium hydrogen phosphate or above combination in any wherein.
6. compositions described in claim 1 or 2, said composition contains calcium chloride or calcium carbonate or both combination in any.
7. compositions described in claim 1 or 2, said composition contains magnesium chloride or magnesium sulfate or both combination in any.
8. compositions described in claim 1 or 2, can be used for the sterilization of wound surface, skin, mucosa, tract, and when sterilization is antibacterial, electrolyte supplement balanced salt, prevents dehydration, fast quick-recovery normal physiological function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410284959.2A CN104069127A (en) | 2014-02-22 | 2014-06-24 | Composition containing electrolyte balance salt and bromogeramine and preparation method thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410062503 | 2014-02-22 | ||
| CN201410062503.1 | 2014-02-22 | ||
| CN201410284959.2A CN104069127A (en) | 2014-02-22 | 2014-06-24 | Composition containing electrolyte balance salt and bromogeramine and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104069127A true CN104069127A (en) | 2014-10-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201410284959.2A Pending CN104069127A (en) | 2014-02-22 | 2014-06-24 | Composition containing electrolyte balance salt and bromogeramine and preparation method thereof |
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| CN (1) | CN104069127A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860891A (en) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | A kind of benzalkonium bromide sodium choride irrigation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017472A1 (en) * | 1999-09-08 | 2001-03-15 | Watson Pharmaceuticals, Inc. | Using quaternary ammonium salts for transdermal drug delivery |
| CN103202826A (en) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Benzalkonium chloride and sodium bicarbonate composite disinfectant |
-
2014
- 2014-06-24 CN CN201410284959.2A patent/CN104069127A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001017472A1 (en) * | 1999-09-08 | 2001-03-15 | Watson Pharmaceuticals, Inc. | Using quaternary ammonium salts for transdermal drug delivery |
| CN103202826A (en) * | 2013-04-18 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Benzalkonium chloride and sodium bicarbonate composite disinfectant |
Non-Patent Citations (1)
| Title |
|---|
| 迟乾钲: "防止0.1%新洁尔灭溶液乳浊的探讨", 《山东医药》, no. 06, 31 December 1983 (1983-12-31) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860891A (en) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | A kind of benzalkonium bromide sodium choride irrigation and preparation method thereof |
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Application publication date: 20141001 |
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| RJ01 | Rejection of invention patent application after publication |