JP2021172649A - Aqueous solution having hypochlorous acid as main component - Google Patents
Aqueous solution having hypochlorous acid as main component Download PDFInfo
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- aqueous solution
- hypochlorous acid
- main component
- chlorine
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- 239000007864 aqueous solution Substances 0.000 title claims abstract description 117
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 117
- 239000000460 chlorine Substances 0.000 claims abstract description 44
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 41
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229910001413 alkali metal ion Inorganic materials 0.000 claims abstract description 9
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 claims abstract description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 229910001868 water Inorganic materials 0.000 claims description 28
- 239000000126 substance Substances 0.000 claims description 24
- 239000011780 sodium chloride Substances 0.000 claims description 23
- 230000003204 osmotic effect Effects 0.000 claims description 11
- -1 chlorine ions Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- 150000001450 anions Chemical class 0.000 claims description 6
- 230000007797 corrosion Effects 0.000 abstract description 9
- 238000005260 corrosion Methods 0.000 abstract description 9
- 238000003860 storage Methods 0.000 abstract description 8
- 229910052751 metal Inorganic materials 0.000 abstract description 7
- 239000002184 metal Substances 0.000 abstract description 7
- 239000000243 solution Substances 0.000 abstract description 7
- 150000002500 ions Chemical class 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 36
- 238000004659 sterilization and disinfection Methods 0.000 description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 230000001954 sterilising effect Effects 0.000 description 18
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 17
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 17
- 150000003839 salts Chemical class 0.000 description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 8
- 235000011121 sodium hydroxide Nutrition 0.000 description 8
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 7
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 6
- 239000005708 Sodium hypochlorite Substances 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 6
- 238000005868 electrolysis reaction Methods 0.000 description 6
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 4
- 239000001639 calcium acetate Substances 0.000 description 4
- 235000011092 calcium acetate Nutrition 0.000 description 4
- 229960005147 calcium acetate Drugs 0.000 description 4
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 4
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 235000010216 calcium carbonate Nutrition 0.000 description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 4
- 239000001354 calcium citrate Substances 0.000 description 4
- 229960004256 calcium citrate Drugs 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 150000001805 chlorine compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 4
- 239000011654 magnesium acetate Substances 0.000 description 4
- 235000011285 magnesium acetate Nutrition 0.000 description 4
- 229940069446 magnesium acetate Drugs 0.000 description 4
- 235000002538 magnesium citrate Nutrition 0.000 description 4
- 239000004337 magnesium citrate Substances 0.000 description 4
- 229960005336 magnesium citrate Drugs 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 235000011056 potassium acetate Nutrition 0.000 description 4
- 229960004109 potassium acetate Drugs 0.000 description 4
- 239000001508 potassium citrate Substances 0.000 description 4
- 229960002635 potassium citrate Drugs 0.000 description 4
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 4
- 235000011082 potassium citrates Nutrition 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000001632 sodium acetate Substances 0.000 description 4
- 235000017281 sodium acetate Nutrition 0.000 description 4
- 229960004249 sodium acetate Drugs 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000013337 tricalcium citrate Nutrition 0.000 description 4
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 235000011116 calcium hydroxide Nutrition 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000009849 deactivation Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 229940091250 magnesium supplement Drugs 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 description 3
- 239000011736 potassium bicarbonate Substances 0.000 description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 3
- 235000011118 potassium hydroxide Nutrition 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 229960001790 sodium citrate Drugs 0.000 description 3
- 235000011083 sodium citrates Nutrition 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 2
- 235000014824 magnesium bicarbonate Nutrition 0.000 description 2
- 239000002370 magnesium bicarbonate Substances 0.000 description 2
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000714198 Caliciviridae Species 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical group O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 241001263478 Norovirus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000369757 Sapovirus Species 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 229940005991 chloric acid Drugs 0.000 description 1
- 229910001919 chlorite Inorganic materials 0.000 description 1
- 229910052619 chlorite group Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002384 drinking water standard Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000531 effect on virus Effects 0.000 description 1
- 238000002674 endoscopic surgery Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
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- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
本発明は、安定性に優れた次亜塩素酸を主成分とする水溶液に関する。 The present invention relates to an aqueous solution containing hypochlorous acid as a main component, which has excellent stability.
従来、塩素系ハロゲン薬の一つとして次亜塩素酸ナトリウムが、ごく低濃度において細菌に対して即効的な殺菌力を発揮し、またＨＩＶやＨＢＶなどのウイルスに対する効果の面でも最も信頼のおける消毒薬として、生活上の消毒・除菌などの公衆衛生、食品、医療などの様々な分野において広く使用されている。特に最も身近な例として、ノロウイルスやＳＬＶ（サポウイルス）などカリシウイルス科のウイルスやロタウイルスなどのエンベロープをもたないウイルスは、アルコール消毒による除菌が期待できず、次亜塩素酸系による消毒・除菌が第一選択になっている。具体的には、次亜塩素酸ナトリウムを含む水溶液がスプレーなどの形態で、家庭や医療現場における、衣類、食器、ガラス容器、プラスチック容器等の様々な物品や環境の消毒・殺菌／除菌に使用されており、さらには粉末剤が上下水道やプールの殺菌などにも使用されている。また、次亜塩素酸ナトリウムは非常に低濃度において水溶液や水溶液をしみこませたウェットティッシュなどの形態で手指消毒用に使用することも可能であるが、次亜塩素酸ナトリウム塩を水に溶解した次亜塩素酸ナトリウム水溶液は、強アルカリ性であり、その希釈液もまたアルカリ性を示しているため、手指消毒に使用すると、手荒れの原因となる（特許文献１）。 Conventionally, sodium hypochlorite as one of the chlorine-based halogen drugs exerts an immediate bactericidal activity against bacteria at a very low concentration, and is also the most reliable in terms of its effect on viruses such as HIV and HBV. As a disinfectant, it is widely used in various fields such as public health such as disinfection and sterilization in daily life, food, and medical care. As the most familiar example, caliciviridae viruses such as norovirus and SLV (sapovirus) and non-enveloped viruses such as rotavirus cannot be expected to be eradicated by alcohol disinfection, and disinfection by hypochlorite system.・ Disinfection is the first choice. Specifically, an aqueous solution containing sodium hypochlorite is used in the form of a spray for disinfection / sterilization / sterilization of various items such as clothing, tableware, glass containers, plastic containers, and the environment at home and in the medical field. It is used, and powders are also used for sterilization of water and sewage and pools. In addition, sodium hypochlorite can be used for hand disinfection in the form of an aqueous solution or a wet tissue soaked with an aqueous solution at a very low concentration, but sodium hypochlorite salt is dissolved in water. Since the sodium hypochlorite aqueous solution is strongly alkaline and its diluted solution is also alkaline, it causes rough hands when used for hand disinfection (Patent Document 1).
一方、塩化ナトリウムなどを用いる電気分解により製造する次亜塩素酸は、次亜塩素酸ナトリウムと比較して８０倍以上に強力な殺菌・抗ウイルス効果を有するとされており、このような次亜塩素酸水は、アルカリ性の次亜塩素酸ナトリウム水溶液とは異なり酸性を示し、低いｐＨによる金属等の腐食が生じやすい。また、酸性条件では、塩素イオン量が増え、塩素ガスや塩化水素ガスが発生しやすく、次亜塩素酸が分解してしまい、短期間のうちに表示濃度を下回るという問題がある。また、塩素や塩の含有量が多いと金属の腐食が促進されてしまう。 On the other hand, hypochlorous acid produced by electrolysis using sodium chloride or the like is said to have more than 80 times stronger bactericidal and antiviral effects than sodium hypochlorite. Unlike the alkaline sodium hypochlorite aqueous solution, the chlorite water shows acidity and is liable to corrode metals and the like due to a low pH. Further, under acidic conditions, there is a problem that the amount of chlorine ions increases, chlorine gas and hydrogen chloride gas are likely to be generated, hypochlorous acid is decomposed, and the concentration falls below the indicated concentration in a short period of time. In addition, if the content of chlorine and salt is high, metal corrosion is promoted.
これに対し、特許文献２には、陽極室、陰極室、陽極室と陰極室との間に設けられ電解液を含む中間室をそれぞれ隔膜により隔てた２隔膜３室型の電解槽を用い、塩を実質的に含んでいない次亜塩素酸水を製造することが記載されている。 On the other hand, Patent Document 2 uses a two-diameter, three-chamber type electrolytic cell in which an anode chamber, a cathode chamber, and an intermediate chamber containing an electrolytic solution provided between the anode chamber and the cathode chamber are separated by a diaphragm. It is described to produce hypochlorous acid water that is substantially free of salts.
しかしながら、特許文献２の方法では、次亜塩素酸濃度を高くしようとするとｐＨが低下し、総塩素イオン量の高い水溶液となり、保存中に次亜塩素酸濃度が低下するという問題がある。 However, the method of Patent Document 2 has a problem that when an attempt is made to increase the hypochlorous acid concentration, the pH is lowered, the aqueous solution has a high total chlorine ion amount, and the hypochlorous acid concentration is lowered during storage.
したがって、本発明は、より保存安定性に優れた次亜塩素酸を主成分とする水溶液を提供することを課題とする。 Therefore, it is an object of the present invention to provide an aqueous solution containing hypochlorous acid as a main component, which is more excellent in storage stability.
本発明者らが、上記課題を検討した結果、次亜塩素酸を主成分とする水溶液において、水溶液中の塩素の総和の４０ｍｏｌ％以上が次亜塩素酸の塩素であるものとすることにより、より安定な次亜塩素酸を主成分とする水溶液を提供できることを見出し、本発明を完成した。 As a result of examining the above problems, the present inventors have determined that in an aqueous solution containing hypochlorous acid as a main component, 40 mol% or more of the total chlorine in the aqueous solution is chlorine of hypochlorous acid. We have found that a more stable aqueous solution containing hypochlorous acid as a main component can be provided, and completed the present invention.
すなわち、本発明は、
［１］水溶液中の塩素の総和の４０ｍｏｌ％以上、好ましくは５０ｍｏｌ％以上、より好ましくは６０ｍｏｌ％以上、さらに好ましくは７０ｍｏｌ％以上が、次亜塩素酸の塩素である次亜塩素酸を主成分とする水溶液、
［２］アルカリ金属イオンおよびアルカリ土類金属イオンの総和が１ｍＥｑ／Ｌ未満、好ましくは０．８ｍＥｑ／Ｌ以下、より好ましくは含有しない上記［１］記載の水溶液、
［３］水溶液が電解水である上記［１］または［２］記載の水溶液、
［４］上記［１］〜［３］のいずれかに記載の水溶液に、アルカリ性物質を加えてｐＨを５．０〜７．０、好ましくは５．８〜６．５とした水溶液、
［５］使用する前に、アルカリ性物質を加えてｐＨを５．０〜７．０、好ましくは５．８〜６．５として用いるための上記［１］〜［３］のいずれかに記載の水溶液、
［６］使用する前に、ＮａＣｌを加えて浸透圧を１５０〜４００ｍＯｓｍ／Ｌ、好ましくは１５０〜３５０ｍＯｓｍ／Ｌ、より好ましくは２２０〜３００ｍＯｓｍ／Ｌとして用いるための上記［１］〜［５］のいずれかに記載の水溶液、
［７］上記［１］〜［５］のいずれかに記載の水溶液の使用方法であって、
（ｉ）使用する前に、アルカリ性物質を添加してｐＨを５．０〜７．０、好ましくは５．８〜６．５とすること、および／または
（ii）使用する前に、ＮａＣｌを加えて浸透圧を１５０〜４００ｍＯｓｍ／Ｌ、好ましくは１５０〜３５０ｍＯｓｍ／Ｌ、より好ましく２２０〜３００ｍＯｓｍ／Ｌとすること
を含む使用方法、
［８］水溶液中の次亜塩素酸以外に含まれる陰イオン（例えば、Ｃｌ-、ＢｒＯ3 -、ＳＯ4 2-、ＮＯ3 -など）の総和が、１０ｍｇ／Ｌ未満である上記［１］〜［６］のいずれかに記載の水溶液、ならびに
［９］水溶液中に含まれる次亜塩素酸以外の塩素イオンが９ｍｇ／Ｌ未満であり、かつ塩素イオン以外の水溶液中の陰イオン（例えば、ＢｒＯ3 -、ＳＯ4 2-、ＮＯ3 -など）の総和が１ｍｇ／Ｌ以下である、ｐＨ５．０〜７．０である上記［１］〜［６］のいずれかに記載の水溶液
に関する。
That is, the present invention
[1] 40 mol% or more, preferably 50 mol% or more, more preferably 60 mol% or more, still more preferably 70 mol% or more of the total chlorine in the aqueous solution is mainly composed of hypochlorous acid, which is chlorine of hypochlorous acid. Aqueous solution,
[2] The aqueous solution according to [1] above, wherein the sum of alkali metal ions and alkaline earth metal ions is less than 1 mEq / L, preferably 0.8 mEq / L or less, and more preferably not contained.
[3] The aqueous solution according to the above [1] or [2], wherein the aqueous solution is electrolyzed water.
[4] An aqueous solution obtained by adding an alkaline substance to the aqueous solution according to any one of [1] to [3] above to adjust the pH to 5.0 to 7.0, preferably 5.8 to 6.5.
[5] The above-mentioned [1] to [3] for adding an alkaline substance and using the pH as 5.0 to 7.0, preferably 5.8 to 6.5 before use. Aqueous solution,
[6] Of the above [1] to [5] for adding NaCl and using the osmotic pressure as 150 to 400 mOsm / L, preferably 150 to 350 mOsm / L, more preferably 220 to 300 mOsm / L before use. Any aqueous solution,
[7] The method for using the aqueous solution according to any one of the above [1] to [5].
(I) Add an alkaline substance to bring the pH to 5.0-7.0, preferably 5.8-6.5 prior to use, and / or (ii) NaCl before use. In addition, a method of use comprising setting the osmotic pressure to 150 to 400 mOsm / L, preferably 150 to 350 mOsm / L, more preferably 220 to 300 mOsm / L.
[8] the anion contained in the non-hypochlorite in aqueous solution (e.g., Cl -, BrO 3 -, SO 4 2-, NO 3 - , etc.) the sum of, the less than 10 mg / L [1] ~ [6] The aqueous solution according to any one of [6] and the aqueous solution [9] contain less than 9 mg / L of chloride ions other than hypochlorous acid, and anions (for example, anions) in the aqueous solution other than chlorine ions. BrO 3 -, SO 4 2-, NO 3 - is the sum of, etc.) the following 1 mg / L, about aqueous solution according to any one of [1] to [6] is pH 5.0-7.0.
本発明によれば、次亜塩素酸を主成分とする水溶液において、水溶液中の塩素の総和の４０ｍｏｌ％以上が次亜塩素酸の塩素であるものとすることにより、より保存安定性が優れた次亜塩素酸を主成分とする水溶液を提供することができる。 According to the present invention, in an aqueous solution containing hypochlorous acid as a main component, storage stability is further improved by assuming that 40 mol% or more of the total chlorine in the aqueous solution is chlorine of hypochlorous acid. An aqueous solution containing hypochlorous acid as a main component can be provided.
（次亜塩素酸を主成分とする水溶液）
本発明の実施の形態１によれば、次亜塩素酸を主成分とする水溶液は、水溶液中の塩素の総和の４０ｍｏｌ％以上が次亜塩素酸の塩素であることを特徴とする。これは、水溶液中の次亜塩素酸の量を、水溶液中、塩素原子を含む成分のｍｏｌ当量の総和を１００ｍｏｌ％として次亜塩素酸に由来する塩素のモル量の割合により示すものである。これにより、水溶液中にＨＣｌを含む場合であっても、ＨＣｌの量は水溶液中の塩素の総和の６０ｍｏｌ％を超えることはなく、水溶液のｐＨをなるべく中性に近づけることができ、保存安定性に優れた次亜塩素酸を主成分とする水溶液を得ることができると考えられる。また、そのような水溶液は、金属腐食や樹脂の劣化への懸念も低いものとなる。
(Aqueous solution containing hypochlorous acid as the main component)
According to the first embodiment of the present invention, the aqueous solution containing hypochlorous acid as a main component is characterized in that 40 mol% or more of the total chlorine in the aqueous solution is chlorine of hypochlorous acid. This is shown by the ratio of the molar amount of chlorine derived from hypochlorous acid, with the total amount of mol equivalents of the components containing chlorine atoms in the aqueous solution as 100 mol%. As a result, even when HCl is contained in the aqueous solution, the amount of HCl does not exceed 60 mol% of the total amount of chlorine in the aqueous solution, and the pH of the aqueous solution can be made as close to neutral as possible, and storage stability can be achieved. It is considered that an aqueous solution containing hypochlorous acid as a main component can be obtained. In addition, such an aqueous solution has less concern about metal corrosion and resin deterioration.
本明細書中において、濃度の単位として用いる「ｐｐｍ」（ｍｇ／ｋｇ）は、特に断りのない限り、ｍｇ／Ｌを置き換えたものとして使用される。 In the present specification, "ppm" (mg / kg) used as a unit of concentration is used as a replacement of mg / L unless otherwise specified.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液においては、水溶液中の塩素の総和の４０ｍｏｌ％以上が次亜塩素酸の塩素、すなわち次亜塩素酸由来の塩素であり、５０ｍｏｌ％以上が好ましく、６０ｍｏｌ％以上がより好ましく、７０ｍｏｌ％以上がさらに好ましく、８０ｍｏｌ％以上が特に好ましく、９０ｍｏｌ％以上が最も好ましい。水溶液中の塩素の総量が多いと塩素ガスが発生しやすくなる。例えば、水溶液が電解水の場合においては、次亜塩素酸由来の塩素の水溶液中の塩素の総和に対する割合が、４０ｍｏｌ％未満であると、塩化水素の割合が増加し、塩化水素による刺激や腐食などの被害が大きくなる傾向がある。金属の腐食とは、金属イオンと塩素や塩基(水酸基、硝酸基、硫酸基等)、酸素などと結合することを指し、金属中の電荷が奪われ、イオン化し脱落することで発生する。 In the aqueous solution containing hypochlorous acid as a main component according to the first embodiment, 40 mol% or more of the total chlorine in the aqueous solution is chlorine of hypochlorous acid, that is, chlorine derived from hypochlorous acid, which is 50 mol%. The above is preferable, 60 mol% or more is more preferable, 70 mol% or more is further preferable, 80 mol% or more is particularly preferable, and 90 mol% or more is most preferable. If the total amount of chlorine in the aqueous solution is large, chlorine gas is likely to be generated. For example, when the aqueous solution is electrolyzed water, if the ratio of chlorine derived from hypochlorous acid to the total amount of chlorine in the aqueous solution is less than 40 mol%, the ratio of hydrogen chloride increases, and irritation and corrosion due to hydrogen chloride There is a tendency for damage such as to increase. Corrosion of metal refers to the binding of metal ions with chlorine, bases (hydroxyl group, nitric acid group, sulfate group, etc.), oxygen, etc., and occurs when the electric charge in the metal is deprived, ionized and dropped off.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液において、「次亜塩素酸を主成分とする」とは、溶媒としての水以外の代表的な成分として次亜塩素酸を含むことを意味し、次亜塩素酸が構成成分の大半を占めるというような意味や次亜塩素酸が水以外の成分中、最も多い成分であるというような意味を示すものではない。このため、その消毒・殺菌機能や本発明の効果である保存安定性に悪影響を与えない範囲であれば、主な成分として水と次亜塩素酸以外に他の成分、特に塩素を含む成分やｐＨを調節する成分などが含まれていてもよく、例えば、ＨＣｌを含むことができる。これに対し、従来の次亜塩素酸水では、未分解の塩化ナトリウムや、ｐＨの成分である塩化水素の含有量が多く、次亜塩素酸の割合は、実施の形態１に係る溶液に比べて低いものである。 In the aqueous solution containing hypochlorous acid as a main component according to the first embodiment, "having hypochlorous acid as a main component" means that hypochlorous acid is contained as a typical component other than water as a solvent. It does not mean that hypochlorous acid occupies most of the constituents or that hypochlorous acid is the most abundant component among the components other than water. Therefore, as long as it does not adversely affect the disinfection / sterilization function and the storage stability which is the effect of the present invention, other components other than water and hypochlorous acid, especially those containing chlorine, are the main components. A component for adjusting pH may be contained, and for example, HCl can be contained. On the other hand, the conventional hypochlorous acid water contains a large amount of undecomposed sodium chloride and hydrogen chloride which is a component of pH, and the ratio of hypochlorous acid is higher than that of the solution according to the first embodiment. Is low.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液を調製する際に使用する水は、予定していない成分、例えば水道水中に含まれる、金属イオン、有機物などの混入を抑えるため、純水、精製水、イオン交換水などを使用することが好ましい。 The water used for preparing the aqueous solution containing hypochlorous acid as the main component according to the first embodiment is to suppress the contamination of unplanned components such as metal ions and organic substances contained in tap water. It is preferable to use pure water, purified water, ion-exchanged water, or the like.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液においては、アルカリ金属イオンやアルカリ土類金属イオンをできるだけ含まないことが好ましく、具体的には、アルカリ金属イオンおよびアルカリ土類金属イオンの総和は、１ｍＥｑ／Ｌ未満が好ましく、０．８ｍＥｑ／Ｌ以下がより好ましく、０．５ｍＥｑ／Ｌ以下がさらに好ましい。アルカリ金属イオンやアルカリ土類金属イオンの総和を１ｍＥｑ／Ｌ未満とすることにより、塩素ガスの発生を抑制し、安定性が高くなる傾向がある。言い換えれば、塩素の対イオンとなる、アルカリ金属イオン、アルカリ土類金属イオンを極力含有させないことにより、塩化水素ガスの発生、次亜塩素酸の分解（失活）を抑制することができる。このような水溶液は、室内に散布した場合に、塩化水素および、塩分濃度が低い事から、腐食特に電子基板などへの影響を低く抑えることが可能となる。 The aqueous solution containing hypochlorous acid as a main component according to the first embodiment preferably contains as little alkali metal ions and alkaline earth metal ions as possible, and specifically, alkali metal ions and alkaline earth metal ions. The total sum is preferably less than 1 mEq / L, more preferably 0.8 mEq / L or less, still more preferably 0.5 mEq / L or less. By setting the total sum of alkali metal ions and alkaline earth metal ions to less than 1 mEq / L, the generation of chlorine gas tends to be suppressed and the stability tends to be improved. In other words, by not containing alkali metal ions and alkaline earth metal ions, which are counterions of chlorine, as much as possible, it is possible to suppress the generation of hydrogen chloride gas and the decomposition (deactivation) of hypochlorous acid. When such an aqueous solution is sprayed indoors, it has a low concentration of hydrogen chloride and salt, so that it is possible to suppress the influence on corrosion, particularly on an electronic substrate, to a low level.
必要な場合にｐＨの調整のために含有させるアルカリ金属イオンやアルカリ土類金属イオンは、特に限定されるものではなく、それぞれ塩の形態で加えることができる。そのようなアルカリ金属イオンの塩としては、ナトリウム（Ｎａ）またはカリウム（Ｋ）の塩が挙げられ、アルカリ土類金属イオンの塩としては、マグネシウム（Ｍｇ）またはカルシウム（Ｃａ）の塩が挙げられる。一方、ルビジウム（Ｒｂ）やオスミウム（Ｏｓ）の塩は、発がん性が指摘されているため、用いないことが好ましい。 The alkali metal ions and alkaline earth metal ions contained for adjusting the pH when necessary are not particularly limited, and can be added in the form of salts, respectively. Examples of such alkali metal ion salts include sodium (Na) or potassium (K) salts, and examples of alkaline earth metal ion salts include magnesium (Mg) or calcium (Ca) salts. .. On the other hand, salts of rubidium (Rb) and osmium (Os) have been pointed out to be carcinogenic, so it is preferable not to use them.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液において、水溶液中の陰イオンは、次亜塩素酸以外の塩化物濃度が１ｍｍｏｌ／Ｌ未満であることが好ましく、０．９ｍｍｏｌ／Ｌ以下がより好ましく、０．４ｍｍｏｌ／Ｌ以下がさらに好ましい。 In the aqueous solution containing hypochlorous acid as a main component according to the first embodiment, the anion in the aqueous solution preferably has a chloride concentration other than hypochlorous acid of less than 1 mmol / L, preferably 0.9 mmol / L. The following is more preferable, and 0.4 mmol / L or less is further preferable.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液は電解水であることが好ましく、具体的には塩酸または塩化ナトリウムを原料とした電気分解をおこなうことにより得られる次亜塩素酸を主成分とする電解水であることが好ましい。 The aqueous solution containing hypochlorous acid as a main component according to the first embodiment is preferably electrolyzed water, and specifically, hypochlorous acid obtained by performing electrolysis using hydrochloric acid or sodium chloride as a raw material. It is preferably electrolyzed water as the main component.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液のｐＨは２．７以上が好ましく、３．２以上がより好ましく、３．５以上がさらに好ましく、５．８以上が特に好ましい。次亜塩素酸を主成分とする水溶液のｐＨを２．７以上とすることにより、腐食性が低減し、様々な用途に使用することができる傾向がある。特に、加湿器や空気清浄機などに次亜塩素酸を主成分とする水溶液を使用する場合には、装置に使用する部品の腐食や劣化が懸念されるため、ｐＨは３．２以上が好ましい。ｐＨを３．２以上とすることにより、塩素ガス（塩化水素ガス）の発生をより抑制することができる。また、次亜塩素酸を主成分とする水溶液のｐＨを５．８以上かつ６．５以下とすることが好ましく、これにより粘膜等への刺激が少なくなると同時に飲用水基準に適合するものとなる。 The pH of the aqueous solution containing hypochlorous acid as a main component according to the first embodiment is preferably 2.7 or more, more preferably 3.2 or more, further preferably 3.5 or more, and particularly preferably 5.8 or more. By setting the pH of the aqueous solution containing hypochlorous acid as the main component to 2.7 or higher, the corrosiveness is reduced and there is a tendency that the aqueous solution can be used for various purposes. In particular, when an aqueous solution containing hypochlorous acid as a main component is used in a humidifier or an air purifier, the pH is preferably 3.2 or higher because there is a concern about corrosion and deterioration of parts used in the device. .. By setting the pH to 3.2 or higher, the generation of chlorine gas (hydrogen chloride gas) can be further suppressed. Further, the pH of the aqueous solution containing hypochlorous acid as a main component is preferably 5.8 or more and 6.5 or less, which reduces irritation to mucous membranes and the like and at the same time conforms to the drinking water standard. ..
実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、その低すぎないｐＨと、強力な殺菌・抗ウイルス力という特性により、様々な用途に使用することができ、例えば、生活上の消毒・除菌などの公衆衛生、食品、医療などの様々な分野において広く使用することができる。家庭や医療現場における、衣類、食器、ガラス容器、プラスチック容器等の様々な物品や環境の消毒・殺菌／除菌に好適に用いることができ、特に、手指洗浄（手洗い除菌）などの皮膚の洗浄・除菌、空間の除菌に好適に用いられる。特に、塩を含まず、ｐＨが低すぎない態様においては、腐食に対する懸念が少なく、水道水では、貯水タンク内でカビなどの菌類が発生し、発生した菌をまき散らすことがあり、また、殺菌効果の高い次亜塩素酸を含有するため、装置のみならず、空間の衛生度の維持も可能であるため、加湿器や空気清浄機などに水道水の代わりに用いることが好ましい。 The aqueous solution containing hypochlorous acid as a main component according to the first embodiment can be used for various purposes due to its not too low pH and strong bactericidal and antiviral properties, for example, in daily life. It can be widely used in various fields such as public health such as disinfection and sterilization of viruses, food, and medical care. It can be suitably used for disinfection / sterilization / sterilization of various items such as clothing, tableware, glass containers, plastic containers, etc. at home and medical sites, and in particular, for skin such as hand washing (hand washing sterilization). It is suitably used for cleaning / sterilization and sterilization of space. In particular, in a mode that does not contain salt and the pH is not too low, there is little concern about corrosion, and in tap water, fungi such as mold may be generated in the water storage tank, and the generated bacteria may be scattered and sterilized. Since it contains highly effective hypochlorous acid, it is possible to maintain the hygiene of not only the equipment but also the space, so it is preferable to use it in a humidifier, an air purifier, etc. instead of tap water.
実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、種々の方法により調製することができる。例えば、まず、上述した２隔膜３室型の電解槽において、電解液として塩化ナトリウム水溶液を用いて電気分解を行い、陽極室で得られた酸性の次亜塩素酸水を得る。この際、塩化ナトリウムと水による電気分解では、通常、陽極に塩素、陰極にナトリウムが泳動し、泳動した塩素が、水と反応して塩化水素（ＨＣｌ）と次亜塩素酸（ＨＣｌＯ）を生成し、酸素ガスが発生する。陰極では、ナトリウムが水と反応し、水酸化ナトリウムを生成し、水素ガスが発生する。塩化ナトリウムと水との反応は、次式のように、化学量論的に次亜塩素酸と塩化水素の生成割合は１：１以上にはならないため、次亜塩素酸の生成割合が塩化水素を上回ることはない。
２ＮａＣｌ＋Ｈ2Ｏ → ２ＮａＯＨ＋ＨＣｌ＋ＨＣｌＯ
次に、得られた酸性の次亜塩素酸水を再度電気分解し、塩化水素を次亜塩素酸へと変換し、塩酸に対する次亜塩素酸の割合を増加させることができる。この塩酸に対する次亜塩素酸の割合を増加させる処理を行うことにより、同時にｐＨを中性側へと傾けることができる。所望の塩酸に対する次亜塩素酸の割合や、所望のｐＨを得るために、この処理（次亜塩素酸水の電気分解）を、必要な回数、繰り返し行うことができる。
The aqueous solution containing hypochlorous acid as a main component according to the first embodiment can be prepared by various methods. For example, first, in the above-mentioned two-diaphragm three-chamber type electrolytic cell, electrolysis is performed using an aqueous sodium chloride solution as an electrolytic solution to obtain an acidic hypochlorous acid water obtained in the anode chamber. At this time, in electrolysis with sodium chloride and water, chlorine is usually migrated to the anode and sodium is migrated to the cathode, and the migrated chlorine reacts with water to generate hydrogen chloride (HCl) and hypochlorous acid (HClO). Then, oxygen gas is generated. At the cathode, sodium reacts with water to produce sodium hydroxide, producing hydrogen gas. In the reaction between sodium chloride and water, the production ratio of hypochlorous acid and hydrogen chloride does not become more than 1: 1 in terms of chemical quantity as shown in the following equation, so the production ratio of hypochlorous acid is hydrogen chloride. Will not exceed.
2NaCl + H 2 O → 2 NaOH + HCl + HClO
Next, the obtained acidic hypochlorous acid water can be electrolyzed again to convert hydrogen chloride into hypochlorous acid, and the ratio of hypochlorous acid to hydrochloric acid can be increased. By performing this treatment to increase the ratio of hypochlorous acid to hydrochloric acid, the pH can be tilted toward the neutral side at the same time. This treatment (electrolysis of hypochlorous acid water) can be repeated as many times as necessary in order to obtain the ratio of hypochlorous acid to the desired hydrochloric acid and the desired pH.
本発明の実施の形態２によれば、本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液に、アルカリ性物質を加えてｐＨを５．０〜７．０としたものである。次亜塩素酸の解離定数は７．５であるため、ｐＨを７．０以下とすることで、水溶液中の非解離型の次亜塩素酸の割合が５０％を超え（ｐＨを６．５以下とすることにより、水溶液中の非解離型の次亜塩素酸の割合が９０％以上となる）、より高い殺菌性能を示すことができる。また、ｐＨを５．８以上とすることで、飲用水の基準に適合するものとなる。実施の形態２においては、ｐＨを５．８〜６．５とすることがより好ましい。ここで、アルカリ性物質としては、種々のｐＨ調節剤を使用することができ、具体的には、水酸化ナトリウム、水酸化カリウム、水酸化カルシウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素カルシウム、炭酸水素マグネシウム、酢酸ナトリウム、酢酸カリウム、酢酸カルシウム、酢酸マグネシウム、クエン酸ナトリウム、クエン酸カリウム、クエン酸カルシウムまたはクエン酸マグネシウムやそれらの水溶液などがあげられ、なかでも水酸化ナトリウムやその水溶液が特に好ましく使用される。 According to the second embodiment of the present invention, an alkaline substance is added to the aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention to adjust the pH to 5.0 to 7.0. be. Since the dissociation constant of hypochlorous acid is 7.5, by setting the pH to 7.0 or less, the proportion of non-dissociated hypochlorous acid in the aqueous solution exceeds 50% (pH is 6.5). By setting the following, the proportion of non-dissociated hypochlorous acid in the aqueous solution becomes 90% or more), and higher bactericidal performance can be exhibited. Further, by setting the pH to 5.8 or higher, the pH conforms to the standard for drinking water. In the second embodiment, the pH is more preferably 5.8 to 6.5. Here, as the alkaline substance, various pH adjusting agents can be used, and specifically, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium hydrogencarbonate, potassium hydrogencarbonate, calcium hydrogencarbonate, carbonic acid. Examples thereof include magnesium hydrogen hydrogen, sodium acetate, potassium acetate, calcium acetate, magnesium acetate, sodium citrate, potassium citrate, calcium citrate or magnesium citrate and their aqueous solutions, and sodium hydroxide and its aqueous solution are particularly preferable. used.
実施の形態２にかかる水溶液は、そのｐＨが中性〜弱酸性の５〜７であることから、皮膚のｐＨに近いものとなり、酸による刺激やアルカリによるかゆみが発生することが激減する。また、アルカリ側に傾けないことにより、トリハロメタン族の生成も抑制することができる。室内に散布した場合に、塩化水素および、塩分濃度が低い事から、腐食特に電子基板などへの影響を低く抑える事が可能となる。実施の形態１に係る水溶液の用途に加え、より様々な用途に使用することができ、例えば、特に、手指洗浄（手洗い除菌）などの皮膚の洗浄・除菌、空間の除菌、器具等の除菌、褥瘡の除菌などに好適に用いられる。 Since the pH of the aqueous solution according to the second embodiment is 5 to 7 which is neutral to weakly acidic, the pH is close to that of the skin, and irritation due to acid and itching due to alkali are drastically reduced. In addition, the formation of trihalomethanes can be suppressed by not tilting to the alkaline side. When sprayed indoors, the concentration of hydrogen chloride and salt is low, so it is possible to suppress the effects of corrosion, especially on electronic substrates, to a low level. In addition to the use of the aqueous solution according to the first embodiment, it can be used for various purposes, for example, skin washing / sterilization such as hand washing (hand washing sterilization), space sterilization, equipment, etc. It is preferably used for sterilization of pressure ulcers and pressure ulcers.
本発明の実施の形態３によれば、本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、使用する前に、アルカリ性物質を加えてｐＨを５．０〜７．０として用いるものであることを特徴とする。次亜塩素酸の解離定数は７．５であるため、ｐＨを７．０以下とすることで、水溶液中の非解離型の次亜塩素酸の割合が５０％を超え（ｐＨを６．５以下とすることにより、水溶液中の非解離型の次亜塩素酸の割合が９０％以上となる）、より高い殺菌性能を示すことができる。また、ｐＨを５．０以上とすることで、飲用水の基準に適合するものとなる。実施の形態３においては、ｐＨは、５．８〜６．５として用いるものであることがより好ましい。ここで、アルカリ性物質としては、種々のｐＨ調節剤を使用することができ、具体的には、水酸化ナトリウム、水酸化カリウム、水酸化カルシウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素カルシウム、炭酸水素マグネシウム、酢酸ナトリウム、酢酸カリウム、酢酸カルシウム、酢酸マグネシウム、クエン酸ナトリウム、クエン酸カリウム、クエン酸カルシウムまたはクエン酸マグネシウムやそれらの水溶液などがあげられ、なかでも水酸化ナトリウムやその水溶液が中和反応後に塩化ナトリウムになるので、生体への影響の点から特に好ましく使用される。 According to the third embodiment of the present invention, the aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention is added with an alkaline substance to adjust the pH to 5.0 to 7. It is characterized in that it is used as 0. Since the dissociation constant of hypochlorous acid is 7.5, by setting the pH to 7.0 or less, the proportion of non-dissociated hypochlorous acid in the aqueous solution exceeds 50% (pH is 6.5). By setting the following, the proportion of non-dissociated hypochlorous acid in the aqueous solution becomes 90% or more), and higher bactericidal performance can be exhibited. Further, by setting the pH to 5.0 or higher, it conforms to the standard for drinking water. In the third embodiment, it is more preferable that the pH is set to 5.8 to 6.5. Here, as the alkaline substance, various pH adjusting agents can be used, and specifically, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium hydrogencarbonate, potassium hydrogencarbonate, calcium hydrogencarbonate, carbonic acid. Examples include magnesium hydrogen hydrogen, sodium acetate, potassium acetate, calcium acetate, magnesium acetate, sodium citrate, potassium citrate, calcium citrate or magnesium citrate and their aqueous solutions, among which sodium hydroxide and its aqueous solution are neutralized. Since it becomes sodium chloride after the reaction, it is particularly preferably used from the viewpoint of its effect on the living body.
本発明の実施の形態４によれば、本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、使用する前に、ＮａＣｌを加えて浸透圧を１５０〜４００ｍＯｓｍ／Ｌとして用いるものであることを特徴とする。上記に説明した本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、塩を極力含有させないことが好ましい態様である。このため、浸透圧が生理食塩水とは異なるものとなっている場合には、例えば、創傷洗浄などの医療用途に用いると、血液に触れた際、浸透圧の違いで赤血球を損傷させるおそれがあり、使用する前に浸透圧を調整する必要がある。浸透圧は溶血を起こさぬように調整することが好ましく、１５０〜３５０ｍＯｓｍ／Ｌに調整することがより好ましく、２２０〜３００ｍＯｓｍ／Ｌに調整することがさらに好ましい。ＮａＣｌを大量に投与すると、塩素ガス（Ｃｌ2）が生成されやすくなるため、化学平衡により、次亜塩素酸の分解が促進され失活（劣化）速度が速くなる。このため、塩化物は使用する直前に混合することが好ましい。 According to the fourth embodiment of the present invention, the aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention is added with NaCl to set the osmotic pressure to 150 to 400 mOsm / L before use. It is characterized in that it is used. The aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention described above preferably contains as little salt as possible. Therefore, if the osmotic pressure is different from that of physiological saline, for example, when used for medical purposes such as wound cleaning, there is a risk of damaging red blood cells due to the difference in osmotic pressure when in contact with blood. Yes, it is necessary to adjust the osmotic pressure before use. The osmotic pressure is preferably adjusted so as not to cause hemolysis, more preferably 150 to 350 mOsm / L, and even more preferably 220 to 300 mOsm / L. When a large amount of NaCl is administered, chlorine gas (Cl 2 ) is easily generated, so that the chemical equilibrium promotes the decomposition of hypochlorous acid and accelerates the deactivation (deterioration) rate. For this reason, chlorides are preferably mixed immediately before use.
本発明の実施の形態５によれば、本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液は、使用する前に、アルカリ性物質およびＮａＣｌを加えてｐＨを５．０〜７．０、かつ浸透圧を１５０〜４００ｍＯｓｍ／Ｌとして用いるものであることを特徴とする。生成した次亜塩素酸水中にＨＣｌやＮａＣｌなどの塩化物を大量に投与すると、塩素ガス（Ｃｌ2）が生成されやすくなるため、化学平衡により、次亜塩素酸の分解が促進さる。このため、塩化物は使用する直前に混合することが好ましい。したがって、アルカリ性物質とＮａＣｌとは、同じタイミング加えてもよく、それぞれ別々に時間を空けて加えることもできるが、別々に時間を空けて加える場合には、アルカリ性物質を先に加えることが好ましい。 According to the fifth embodiment of the present invention, the aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention is added with an alkaline substance and NaCl to have a pH of 5.0 to 5.0 to before use. It is characterized in that it is used at 7.0 and the osmotic pressure is 150 to 400 mOsm / L. When a large amount of chlorides such as HCl and NaCl is administered into the generated hypochlorite water, chlorine gas (Cl 2 ) is easily generated, and the chemical equilibrium promotes the decomposition of hypochlorous acid. For this reason, chlorides are preferably mixed immediately before use. Therefore, the alkaline substance and NaCl may be added at the same timing or separately at intervals, but when they are added separately at intervals, it is preferable to add the alkaline substance first.
本発明の実施の形態６によれば、本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液に、（ｉ）使用する前に、アルカリ性物質を添加してｐＨを５．０〜７．０、好ましくは５．８〜６．５とし、および／または（ii）使用する前に、ＮａＣｌを加えて浸透圧を１５０〜４００ｍＯｓｍ／Ｌ、好ましくは１５０〜３５０ｍＯｓｍ／Ｌ、より好ましく２２０〜３００ｍＯｓｍ／Ｌとして使用する使用方法であることを特徴とする。使用するアルカリ性物質や、添加の態様、この使用方法の効果などについては、上記実施の形態３〜５に記載したとおりである。 According to the sixth embodiment of the present invention, an alkaline substance is added to the aqueous solution containing hypochlorous acid as a main component according to the first embodiment of the present invention (i) to adjust the pH. From 0 to 7.0, preferably 5.8 to 6.5, and / or (ii) the addition of NaCl to an osmotic pressure of 150 to 400 mOsm / L, preferably 150 to 350 mOsm / L before use. It is characterized in that it is a usage method preferably used as 220 to 300 mOsm / L. The alkaline substance to be used, the mode of addition, the effect of this usage method, and the like are as described in the above-described embodiments 3 to 5.
なお、本発明の実施の形態３〜６において、「使用する前に」とは、特に限定されるものではないが、例えば、使用の１週間前から使用直前までを意味し、使用の直前〜１日前が好ましく、できるだけ８時間以内に使用することが失活速度の点からより好ましい。 In the third to sixth embodiments of the present invention, "before use" is not particularly limited, but means, for example, from one week before use to immediately before use, and immediately before use. One day before is preferable, and it is more preferable to use it within 8 hours as much as possible from the viewpoint of deactivation rate.
（用時混合製剤）
本発明の実施の形態３〜５におけるアルカリ性物質やＮａＣｌとの使用前混合については、市販のＮａＣｌやアルカリ性物質を用いて様々な手法で実現することができるが、例えば、（Ａ）上記に説明した本発明の実施の形態１にかかる次亜塩素酸を主成分とする水溶液（（Ａ）液とも称する。）に、（Ｂ）アルカリ性物質（（Ｂ）剤とも称する。）、および／または（Ｃ）ＮａＣｌを含む剤（（Ｃ）剤とも称する。）を組み合わせてキットとすることにより用時混合製剤として提供することもできる。
(Mixed formulation at the time of use)
The pre-use mixing with an alkaline substance or NaCl in Embodiments 3 to 5 of the present invention can be realized by various methods using commercially available NaCl or alkaline substance. For example, (A) described above. The aqueous solution (also referred to as (A) solution) containing hypochlorous acid as a main component according to the first embodiment of the present invention, (B) alkaline substance (also referred to as (B) agent), and / or ( C) It is also possible to provide a mixed preparation at the time of use by combining an agent containing NaCl (also referred to as an agent (C)) into a kit.
用時混合製剤において、（Ｂ）剤のアルカリ性物質としては、種々のｐＨ調節剤を使用することができ、具体的には、水酸化ナトリウム、水酸化カリウム、水酸化カルシウム、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素カルシウム、炭酸水素マグネシウム、酢酸ナトリウム、酢酸カリウム、酢酸カルシウム、酢酸マグネシウム、クエン酸ナトリウム、クエン酸カリウム、クエン酸カルシウムまたはクエン酸マグネシウムやそれらの水溶液などがあげられる。 In the time-to-use mixed preparation, various pH adjusting agents can be used as the alkaline substance of the agent (B), specifically, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium hydrogencarbonate, and carbonic acid. Examples thereof include potassium hydrogen hydrogen, calcium hydrogen carbonate, magnesium hydrogen carbonate, sodium acetate, potassium acetate, calcium acetate, magnesium acetate, sodium citrate, potassium citrate, calcium citrate or magnesium citrate, and aqueous solutions thereof.
用時混合製剤において、（Ｃ）剤の塩化ナトリウムを含む剤には、塩化ナトリウム以外にも別の等張化剤を含めることができる。使用できる等張化剤としては、特に限定されるものではないが、例えば、炭酸水素ナトリウム、炭酸水素カリウム、炭酸水素カルシウム、炭酸水素マグネシウム、酢酸ナトリウム、酢酸カリウム、酢酸カルシウム、酢酸マグネシウム、クエン酸ナトリウム、クエン酸カリウム、クエン酸カルシウムまたはクエン酸マグネシウムなどがあげられる。 In the time-to-use mixed preparation, the agent containing sodium chloride of the agent (C) may contain another isotonic agent in addition to sodium chloride. The tonicity agent that can be used is not particularly limited, but for example, sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, magnesium hydrogen carbonate, sodium acetate, potassium acetate, calcium acetate, magnesium acetate, citric acid. Examples include sodium, potassium citrate, calcium citrate or magnesium citrate.
用時混合製剤は、（Ａ）液と、（Ｂ）剤および／または（Ｃ）剤とをそれぞれ別々の容器に封入したキットの形態とすることもできるが、連通可能な隔離手段で区画された少なくとも２室を有する複室容器に、（Ａ）液および（Ｂ）剤をそれぞれ第１室および第２室に収容してなる複室容器製剤とすることが好ましい。このような複室容器としては、２液用時混合型透析液などに使用されているような、例えばポリプロピレン製などのプラスチック製のダブルバッグ型容器や、用時溶解型輸液セットなどに使用されているような両頭針付キット製品などが好ましい。 The time-mixed preparation may be in the form of a kit in which the liquid (A) and the agent (B) and / or the agent (C) are enclosed in separate containers, but they are partitioned by a communicable isolation means. It is preferable to prepare a multi-chamber container formulation in which the liquid (A) and the agent (B) are contained in the first chamber and the second chamber, respectively, in a multi-chamber container having at least two chambers. As such a multi-chamber container, it is used for a double bag type container made of plastic such as polypropylene, which is used for a mixed type dialysate for two liquids, and a dissolution type infusion set for use. A kit product with a double-headed needle is preferable.
本発明の実施の形態４〜５にかかる次亜塩素酸を主成分とする水溶液や上述の用時混合製剤は、外科的手段または非外科的手段により生じた創傷等の血液に触れる傷を洗浄または殺菌、除菌するために用いることや、ネブライザーにより肺へと導入し、肺を除菌するために用いることができる。具体的には、一般的な外科手術、内視鏡手術、ロボット支援腹腔鏡手術、口腔手術、グラフト手術、インプラント手術、トランスプラント手術などの手術、焼灼、切断、放射線、化学療法、熱傷、切り傷、擦過傷、掻き傷、発疹、潰瘍、穿刺創、褥瘡、それらの組み合わせ等が挙げられ、感染管理、ケロイド対策等の用途に用いることが好ましい。 The aqueous solution containing hypochlorous acid as a main component and the above-mentioned time-use mixed preparation according to Embodiments 4 to 5 of the present invention wash wounds that come into contact with blood such as wounds caused by surgical or non-surgical means. Alternatively, it can be used for sterilization and sterilization, or it can be introduced into the lung by a nebulizer and used for sterilization of the lung. Specifically, general surgery, endoscopic surgery, robot-assisted laparoscopic surgery, oral surgery, graft surgery, implant surgery, transplant surgery, etc., ablation, cutting, radiation, chemotherapy, burns, cuts , Scratches, scratches, rashes, ulcers, puncture wounds, decubitus, combinations thereof and the like, and are preferably used for applications such as infection control and anti-keroid surgery.
なお、本明細書において、上記実施の形態１〜６にそれぞれ記載した事項は、矛盾しない限りにおいて、互いに別の実施の形態にも適用されるものとする。 In this specification, the matters described in the above-described first to sixth embodiments shall be applied to different embodiments as long as there is no contradiction.
以下、本発明を実施例にもとづき具体的に説明するが、本発明はこれらの実施例に限定されることを意図するものではない。なお、本発明で得られた次亜塩素酸を主成分とする水溶液は、凍結保存することが可能である。 Hereinafter, the present invention will be specifically described based on examples, but the present invention is not intended to be limited to these examples. The aqueous solution containing hypochlorous acid as a main component obtained in the present invention can be cryopreserved.
実施例１
塩化ナトリウム水溶液を被電解質として、２隔膜３室型電解槽により電気分解し、陽極側から強酸性次亜塩素酸水を得た。得られた強酸性次亜塩素酸水を再電解し、塩化水素を次亜塩素酸へと変換し、塩酸に対する次亜塩素酸の割合を高めた次亜塩素酸を主成分とする水溶液を得た。得られた次亜塩素酸を主成分とする水溶液の次亜塩素酸の濃度は、吸光光度計（ＡＱ−１０２、柴田化学（株）製）を用いて測定し、塩素の総和は、次亜塩素酸濃度、およびｐＨから換算した。なお、ｐＨは、マルチ水質メーター（ＭＭ−６０、東亜ディーケーケー（株）製）により測定した。
Example 1
Using an aqueous sodium chloride solution as an electrolyte, electrolysis was performed in a two-diameter, three-chamber electrolytic cell to obtain strongly acidic hypochlorous acid water from the anode side. The obtained strongly acidic hypochlorous acid water is re-electrolyzed to convert hydrogen chloride into hypochlorous acid to obtain an aqueous solution containing hypochlorous acid as a main component in which the ratio of hypochlorous acid to hydrochloric acid is increased. rice field. The concentration of hypochlorous acid in the obtained aqueous solution containing hypochlorous acid as the main component was measured using an absorptiometer (AQ-102, manufactured by Shibata Chemical Co., Ltd.), and the total amount of chlorine was hypochlorous acid. Converted from chloric acid concentration and pH. The pH was measured with a multi-water quality meter (MM-60, manufactured by DKK-TOA CORPORATION).
比較例１
再電解処理を行わなかった以外は、実施例１と同様にして次亜塩素酸を主成分とする水溶液を得た。得られた次亜塩素酸を主成分とする水溶液の次亜塩素酸の濃度および塩素の総和やその他の物性は、実施例１と同様にして得た。結果を表１に示す。
Comparative Example 1
An aqueous solution containing hypochlorous acid as a main component was obtained in the same manner as in Example 1 except that the reelectrolysis treatment was not performed. The concentration of hypochlorous acid, the total amount of chlorine, and other physical properties of the obtained aqueous solution containing hypochlorous acid as a main component were obtained in the same manner as in Example 1. The results are shown in Table 1.
比較例２
塩酸を被電解質として、無隔膜電解槽により電気分解し、水で希釈して、次亜塩素酸を主成分とする水溶液を得た。得られた次亜塩素酸を主成分とする水溶液の次亜塩素酸の濃度および塩素の総和やその他の物性は、実施例１と同様にして得た。結果を表１に示す。
Comparative Example 2
Using hydrochloric acid as an electrolyte, it was electrolyzed in a diaphragmless electrolytic cell and diluted with water to obtain an aqueous solution containing hypochlorous acid as a main component. The concentration of hypochlorous acid, the total amount of chlorine, and other physical properties of the obtained aqueous solution containing hypochlorous acid as a main component were obtained in the same manner as in Example 1. The results are shown in Table 1.
表１より、実施例１では、比較例１および２よりもｐＨが上昇し、塩酸に対する次亜塩素酸の割合が上昇し、相対的に水溶液中の塩素イオン濃度が減少していることから保存安定性に優れた次亜塩素酸を主成分とする水溶液が得られていることがわかる。実施例１、比較例１および比較例２の次亜塩素酸の塩素の量は、それぞれ水溶液中の塩素の総和に対して約４７ｍｏｌ％、約１８ｍｏｌ％および約３６ｍｏｌ％であった。 From Table 1, in Example 1, the pH was higher than in Comparative Examples 1 and 2, the ratio of hypochlorous acid to hydrochloric acid was increased, and the chloride ion concentration in the aqueous solution was relatively decreased. It can be seen that an aqueous solution containing hypochlorous acid as a main component, which has excellent stability, is obtained. The amounts of chlorine in the hypochlorous acid of Example 1, Comparative Example 1 and Comparative Example 2 were about 47 mol%, about 18 mol% and about 36 mol%, respectively, with respect to the total amount of chlorine in the aqueous solution.
実施例２、比較例３および４
実施例１、比較例１および２で得られた次亜塩素酸を主成分とする水溶液１Ｌに、水酸化ナトリウムを加え、ｐＨを６．５に調整した。実施例２では、ｐＨの調整後に濾過膜による濾過処理により次亜塩素酸以外の塩化物を低減した。得られた水溶液の各物性を表２に示す。
Example 2, Comparative Examples 3 and 4
Sodium hydroxide was added to 1 L of the aqueous solution containing hypochlorous acid as a main component obtained in Example 1 and Comparative Examples 1 and 2, and the pH was adjusted to 6.5. In Example 2, chlorides other than hypochlorous acid were reduced by filtration treatment with a filtration membrane after adjusting the pH. Table 2 shows the physical characteristics of the obtained aqueous solution.
表２より、実施例２では、ｐＨを６．５としても、ナトリウムイオン濃度は０．７０ｍＥｑ／Ｌと低い範囲に抑えられており、比較例３および４と比較して安定性のよい、金属等に対する腐食作用を抑えた次亜塩素酸を主成分とする水溶液を得ることができた。 From Table 2, in Example 2, the sodium ion concentration was suppressed to a low range of 0.70 mEq / L even when the pH was 6.5, and the metal was more stable than Comparative Examples 3 and 4. It was possible to obtain an aqueous solution containing hypochlorous acid as a main component, which suppresses the corrosive action on such substances.
実施例３
塩化ナトリウム水溶液を、実施例１と同様にして次亜塩素酸を主成分とする水溶液を得た。得られた次亜塩素酸を主成分とする水溶液の次亜塩素酸の濃度および塩素の総和やその他の物性は、実施例１と同様にして測定した。結果を表３に示す。
Example 3
An aqueous solution containing hypochlorous acid as a main component was obtained in the same manner as in Example 1. The concentration of hypochlorous acid, the total amount of chlorine, and other physical properties of the obtained aqueous solution containing hypochlorous acid as a main component were measured in the same manner as in Example 1. The results are shown in Table 3.
実施例４
再度再電解を繰り返した以外は、実施例１と同様にして次亜塩素酸を主成分とする水溶液を得た。得られた次亜塩素酸を主成分とする水溶液の次亜塩素酸の濃度および塩素の総和やその他の物性は、実施例１と同様にして測定した。結果を表３に示す。
Example 4
An aqueous solution containing hypochlorous acid as a main component was obtained in the same manner as in Example 1 except that reelectrolysis was repeated again. The concentration of hypochlorous acid, the total amount of chlorine, and other physical properties of the obtained aqueous solution containing hypochlorous acid as a main component were measured in the same manner as in Example 1. The results are shown in Table 3.
表３より、実施例３では、塩酸に対する次亜塩素酸の割合がさらに上昇し、実施例４では塩酸に対する次亜塩素酸の割合がよりさらに上昇し、相対的に水溶液中の塩素イオン濃度が減少していることから保存安定性に優れた次亜塩素酸を主成分とする水溶液が得られていることがわかる。実施例３および４の次亜塩素酸の塩素の量は、それぞれ水溶液中の塩素の総和に対して約５９ｍｏｌ％および約７５ｍｏｌ％であった。 From Table 3, in Example 3, the ratio of hypochlorous acid to hydrochloric acid was further increased, and in Example 4, the ratio of hypochlorous acid to hydrochloric acid was further increased, and the chloride ion concentration in the aqueous solution was relatively high. From the decrease, it can be seen that an aqueous solution containing hypochlorous acid as a main component, which has excellent storage stability, is obtained. The amounts of chlorine in the hypochlorous acids of Examples 3 and 4 were about 59 mol% and about 75 mol%, respectively, with respect to the total amount of chlorine in the aqueous solution.
Claims (9)
（ｉ）使用する前に、アルカリ性物質を添加してｐＨを５．０〜７．０とすること、および／または
（ii）使用する前に、ＮａＣｌを加えて浸透圧を１５０〜４００ｍＯｓｍ／Ｌとすること
を含む使用方法。 The method for using the aqueous solution according to any one of claims 1 to 5.
(I) Add an alkaline substance to bring the pH to 5.0-7.0 before use and / or (ii) Add NaCl to make the osmotic pressure 150-400 mOsm / L before use. Usage including to.
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| WO2024029280A1 (en) * | 2022-08-05 | 2024-02-08 | ニプロ株式会社 | Disinfection or inactivation method for space |
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| WO2023090447A1 (en) * | 2021-11-19 | 2023-05-25 | ニプロ株式会社 | Method and device for producing purified hypochlorous acid aqueous solution, and purified hypochlorous acid aqueous solution |
| WO2024029280A1 (en) * | 2022-08-05 | 2024-02-08 | ニプロ株式会社 | Disinfection or inactivation method for space |
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