JP3219698B2 - Manufacturing method of disinfectant solution - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to hand washing in medical institutions, various welfare facilities, kitchens, general households, etc., washing of various equipment and fixtures, washing of linen, fukin, clothes and footwear, cleaning of walls and floors, The present invention relates to a method for producing a germicidal disinfectant used for cleaning dental impression agents, cleaning artificial dialysis lines, and the like.

[0002]

2. Description of the Related Art In general, if a saline solution is electrolyzed between both electrodes through a membrane such as an ion exchange membrane, high-pH alkaline electrolyzed water is produced on the cathode side with the generation of hydrogen, and the anode side is produced. Is known to produce low pH acidic electrolyzed water containing active chlorine and oxygen. However, the latter acidic electrolyzed water has a strong bactericidal action, is less toxic than conventional general-purpose disinfectants, is less likely to cause rough skin even when used for hand washing, and has been used. Wastewater has attracted attention for sterilization because it does not require special treatment. In recent years, various electrolyzed water generators configured to add a trace amount of sodium chloride to tap water to perform electrolysis and take out acidic electrolyzed water generated on the anode side are commercially available.

The acidic electrolyzed water has a pH of 2.7 or less and a residual chlorine content of 30 to 40 pp obtained by ordinary electrolysis.
m, oxidation-reduction potential (hereinafter referred to as ORP) +1100 m
V or higher, strongly acidic electrolyzed water, PH 4.5 to 5.5 obtained by diluting the water immediately after electrolysis, residual chlorine amount 50 to
There is 80 ppm, ORP +800 to +1000 mV weakly acidic electrolyzed water, and the latter weakly acidic electrolyzed water has an advantage of being excellent in storage stability. The bactericidal action of acidic electrolyzed water is said to be based on the destruction of the microbial habitat by high ORP and the bactericidal effect by hypochlorous acid.

[0004] That is, the microorganisms are ORP at +200 to +820 mV for facultative aerobic microorganisms and -700 to +100 mV for anaerobic microorganisms. But
In the acidic electrolyzed water, the environment of high ORP almost deviating from the region A is exceeded, so that the membrane potential of the organelle exceeds the stabilization limit,
It is understood that energy metabolism and respiration are obstructed, making it difficult to live. The chlorine gas generated by the electrolysis of the salt changes so that the compound form in water shifts to the right side of the following equation as the pH becomes higher. However, Cl ₂ + H ₂ O ← → HCl + HOCl ← → HCl + H ⁺ + OCl ⁻ acidic electrolysis As shown in FIG. 2, most of the water in the PH region is present as hypochlorous acid (HOCl), which is active chlorine. Therefore, the strong oxidizing power of hypochlorous acid causes microorganisms to denature proteins (N-terminal). It is considered that the enzyme activity is lost due to oxidation of the amino group).

[0005]

As described above, acidic electrolyzed water generated on the anode side by electrolysis of a saline solution is considered to be highly useful for sterilization and disinfection. Is very expensive, so it is not economically feasible to introduce it into small-scale facilities or ordinary households that do not require a large amount of disinfectant, Even facilities with high consumption and high consumption have a large burden on equipment costs, so it has been difficult to install them in all necessary locations.

Therefore, in order to promote the use of acidic electrolyzed water for sterilization and disinfection, the emergence of an inexpensive electrolyzed water generator is expected. However, the construction of the electrolysis section, piping, electrical and fluid control, and the like are required. There is naturally a limit in reducing the manufacturing cost of the device, and the cost of maintenance such as replacement due to the life of the electrode is unavoidable, so it is difficult to solve the economic problem, especially when the frequency of use and consumption are small. Can not respond to.

[0007]

SUMMARY OF THE INVENTION In view of the above-mentioned situation, the present inventors have conducted intensive studies in order to provide inexpensively acidic electrolyzed water having high utility for sterilization and disinfection. The idea was changed 180 degrees from the idea of lowering the cost of sterilization, and a sterilizing and disinfecting solution having the same performance and properties as acidic electrolyzed water could be prepared very easily and inexpensively by mixing chemicals without depending on the method of electrolysis of saline solution. And found that the present invention can be provided.

That is, the method for producing a disinfectant solution according to claim 1 of the present invention comprises dissolving a) sodium dichloroisocyanurate and b) an acidic substance or hydrogen peroxide in water to obtain a PH5. 5 or less, residual chlorine amount 30p
The present invention is characterized in that an acidic aqueous solution of not less than pm and not less than ORP (redox potential) +800 mV is prepared. According to this method, the residual chlorine based on sodium dichloroisocyanurate, which is a chlorine agent for the component a dissolved in water, is adjusted to a pH of 5.5 or less by the component b to activate active hypochlorous acid. As it is set as ORP + 800 mV or more depending on the b component, a highly useful disinfectant solution having the same performance and properties as the acidic electrolyzed water generated by the conventional electrolysis of saline is easily obtained. And inexpensively. In addition, the hydrogen peroxide of the component b has an effect of lowering the pH of the aqueous solution by generating hydrochloric acid by reacting with the chlorine of sodium dichloroisocyanurate of the component a.

According to a second aspect of the present invention, in the method for producing a germicidal disinfectant according to the first aspect, the acidic aqueous solution has a pH of 4.5.
~ 5.5, residual chlorine amount 50 ~ 80ppm, redox potential + 800 ~ 1000mV, so that the obtained disinfectant solution is weakly acidic electrolyzed solution which is generated by conventional electrolysis of saline solution. It is equivalent to water.

According to a third aspect of the present invention, in the method for producing a germicidal disinfectant of the second aspect, the component b) is selected from the group consisting of citric acid, malic acid, tartaric acid, maleic acid, succinic acid, oxalic acid, glycolic acid, and acetic acid. Weak acid electrolysis by conventional electrolysis of salt water because it employs at least one acidic substance selected from hydrochloric acid, sulfuric acid, nitric acid, sodium hydrogen sulfate, sulfamic acid, phosphoric acid, or hydrogen peroxide A disinfectant solution corresponding to water can be easily prepared.

According to a fourth aspect of the present invention, in the method for producing a germicidal disinfectant according to the first aspect, the acidic aqueous solution may have a pH of 2.7.
Hereinafter, the residual chlorine amount is 30 to 40 ppm, the oxidation-reduction potential +1
Since the configuration for adjusting the voltage to 100 mV or more is employed, the obtained disinfectant solution corresponds to strongly acidic electrolyzed water generated by conventional electrolysis of saline.

According to a fifth aspect of the present invention, in the method for producing a germicidal disinfectant according to the fourth aspect, the component b) is selected from the group consisting of maleic acid, succinic acid, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and sodium hydrogen sulfate. Since the composition of at least one selected acidic substance is adopted, a disinfecting solution corresponding to strongly acidic electrolyzed water obtained by conventional electrolysis of saline can be easily prepared.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS According to the present invention, in producing a disinfectant solution, sodium dichloroisocyanurate (a) and an acidic substance or hydrogen peroxide (b) may be simply dissolved in water. The amounts of the components a and b and the mixing ratio thereof are set so that the pH of the mixture is an acidic aqueous solution having a pH of 5.5 or less, a residual chlorine content of 30 ppm or more, and an ORP + 800 mV or more. That is, the amount of residual chlorine is determined by the amount of sodium dichloroisocyanurate used as a chlorine agent,
And ORP depend on the amount of the component b, respectively.
Since the PH adjustment effect of the component differs depending on the type, the usage of each of the a and b components may be set so as to satisfy the above-mentioned conditions of PH and ORP according to the type and combination of the component b. Thus, the obtained disinfecting solution has the same performance and properties as the acidic electrolyzed water generated by the conventional electrolysis of saline, and has an excellent disinfecting effect.

[0014] As described above, there are two types of conventional acidic electrolyzed water obtained by electrolysis of saline, which are strongly acidic and weakly acidic. The amounts of the components a and b and the mixing ratio thereof may be set so as to be an acidic aqueous solution corresponding to the PH, the residual chlorine amount, and the ORP in each of the acidic electrolyzed water. That is, in a strongly acidic aqueous solution, the pH is 2.7 or less and the residual chlorine amount is 30.
４０40 ppm, oxidation-reduction potential +1100 mV or more, PH 4.5 to 5.5 in weakly acidic aqueous solution, residual chlorine amount 50 to 8
0 ppm, ORP + 800 to 1000 mV.

The component (a) sodium dichloroisocyanurate (hereinafter abbreviated as SDCI) has an effective chlorine concentration of as high as 60% or more (theoretical value of 64.5%) and has excellent stability of the residual chlorine amount in an aqueous solution. Moreover, it is easily soluble in water and the aqueous solution is almost neutral (pH 6.0 to 7.0 for a 1% aqueous solution).
Therefore, there is an advantage that an acidic aqueous solution of a required residual chlorine amount and PH can be easily prepared with a small use amount of the component b, and is most suitable as a chlorine agent used for preparing the acidic electrolyzed water.

[0016] On the other hand, sodium hypochlorite is the most widely used alkaline chlorinating agent, but there are ordinary products and low-salt products, both of which have different alkalinities. Since there is a difference in alkalinity and available chlorine concentration, it is necessary to measure alkalinity and available chlorine concentration in advance for each type of varieties used in order to prepare a disinfectant solution with the required PH and residual chlorine, and it is unstable Therefore, the residual chlorine amount must be measured successively at the time of use to confirm that the amount is within an appropriate range, and these labors are very complicated. There is a drawback that it increases.

In the case of advanced salad powder, the effective chlorine concentration is 60%.
% Or more, but the use of component b is also large because of its alkalinity. In addition, powdery products having good water solubility are class 1 hazardous substances and have a hygroscopic property and chlorine. There is a problem that granular products which are inferior in stability and do not correspond to dangerous substances are hardly soluble in water and cannot be used. Further, chloramine T is a powder that is easily soluble in water, but has a low effective chlorine concentration of 25% and is more expensive than SDCI.
There is a drawback that the amount of components used increases, and it is not particularly suitable for preparing a strongly acidic aqueous solution corresponding to strongly acidic electrolyzed water.

In addition, trichloroisocyanuric acid, which is structurally similar to SDCI, is a chlorinating agent having a high effective chlorine content of 90%, but it is difficult to prepare a target disinfecting solution because it is hardly soluble in water. is there. Also, chlorine dioxide (ClO ₂ )
And sodium chlorite (NaClO ₂ ), the residual chlorine amount is set to about 80 ppm, and the pH is adjusted by adding an acidic substance.
Is adjusted to 5.5 to 2.7, the ORP is +750 mV
However, the target disinfectant cannot be adjusted.

The acidic substance of the component (b) is obtained by measuring the pH and ORP of the acidic aqueous solution obtained in combination with the SDCI of the component (a).
Can be used without limitation as long as it can be adjusted to a predetermined range, but the following are preferred. That is, PH 4.5 to 5.5, residual chlorine amount 50 to 80 pp
m, ORP + 800 to 1000 mV for preparing a weakly acidic aqueous solution include citric acid, malic acid, tartaric acid, maleic acid, succinic acid, oxalic acid, glycolic acid, acetic acid, hydrochloric acid,
Sulfuric acid, nitric acid, sodium hydrogen sulfate, sulfamic acid, phosphoric acid and the like are preferred. Alternatively, for preparing a strongly acidic aqueous solution having a pH of 2.7 or less, a residual chlorine amount of 30 to 40 ppm, and an ORP of 1100 mV or more, maleic acid, succinic acid, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, sodium hydrogen sulfate and the like can be mentioned. However, succinic acid and acetic acid for preparing a strongly acidic aqueous solution are somewhat inferior in that the amounts used are considerably larger than those of the others.

It is to be noted that citric acid, malic acid, tartaric acid, maleic acid, oxalic acid, glycolic acid, and sulfamic acid are all unsuitable for preparing a strongly acidic aqueous solution.
This is because RP cannot be set to +1100 mV or more. Further, as another acidic substance, for example, boric acid is not suitable because an acidic aqueous solution having a pH of 5.5 or less cannot be prepared. It should be noted that sodium dihydrogen phosphate has a drawback that the amount of use is increased because it is an acidic aqueous solution having a pH of 5.5 or less.

Hydrogen peroxide as the component b is converted to S
By reacting with the chlorine of DCI to generate hydrochloric acid, it has the effect of lowering the pH of the aqueous solution, and thus can be used in place of the acidic substance. However, when the pH of the aqueous solution is 2.7.
It is necessary to add a large amount of hydrogen peroxide to reduce the amount to below, and to compensate for the large consumption of chlorine accompanying this, SDCI
Since the amount of used is also very large, hydrogen peroxide is not suitable for preparing a strongly acidic aqueous solution.

In the present invention, the above-mentioned SDCI of the component a and the acidic substance or the hydrogen peroxide of the component b are dissolved in water to prepare a weakly acidic aqueous solution or a strongly acidic aqueous solution satisfying the above-mentioned residual chlorine content, PH and ORP. However, purified water such as ion-exchanged water and ordinary tap water can be used as the water.

The obtained strongly acidic and weakly acidic aqueous solutions are disinfected with sterilizing solutions having the same action and properties as those of the weakly acidic electrolyzed water and the strongly acidic electrolyzed water produced by the conventional electrolyzed water generating apparatus, respectively. Therefore, it can be used for various sterilization and disinfection applications in place of the electrolyzed water. Its uses include:
For example, hand washing water for disinfection in medical institutions, various welfare facilities, kitchens, households, etc., cleaning of medical and cooking utensils, portable toilets, wagons, shelves, shelves, sinks, etc., and cleaning of walls and floors Examples include wiping, washing of clothing such as linen, fukin, eblon, white robe, and footwear such as slippers. Furthermore, in addition to the above-mentioned general uses, if both weakly acidic and strongly acidic disinfectants are used for disinfecting and cleaning the alginate impression material after obtaining the tooth profile in dentistry, the shape change and surface roughness of the impression material are almost eliminated. There is an advantage that sterilization of bacteria transferred from the mouth of the patient can be carried out without occurrence, and if the artificial dialysis line is used for washing, the calcium carbonate adhering to the line can be removed in a short time together with the sterilization.

In general, a disinfectant solution is prepared by dissolving both components a and b in water at a ratio specified in a manual provided by a manufacturer on the user side. In order to save the trouble of weighing the components a and b, and setting the use ratio, for example,
If a disinfectant is provided in which the components a and b are packaged in an amount and a ratio corresponding to a unit amount of disinfectant such as 5, 10 liters, and the user dissolves it in a predetermined amount of water, Good.

When the above-mentioned disinfectant is used, in particular, a, b
If both components are powdered, both components can be mixed in a predetermined ratio in advance to provide a product in the form of a powder mixture, which is convenient for transportation and storage, and a disinfectant solution for the user. Has the advantage that the preparation of is also easier. In addition, what can be obtained as a powder form includes SDCI of the component a, and citric acid, malic acid, tartaric acid, maleic acid, succinic acid, oxalic acid, sodium hydrogen sulfate, sulfamic acid and the like for the component b.

[0026]

EXAMPLES [Production Example 1 of Disinfectant Solution] Ion-exchanged water is used as dilution water, and citric acid, malic acid, tartaric acid, succinic acid, maleic acid, oxalic acid, and glycolic acid (70% aqueous solution) are used as acidic substances. , Acetic acid,
Hydrochloric acid (1N aqueous solution), sulfuric acid (1N aqueous solution), nitric acid (1N aqueous solution)
Aqueous solution), sodium hydrogen sulfate, sulfamic acid, phosphoric acid (85% aqueous solution), sodium dihydrogen phosphate, and boric acid. Each acidic substance was subjected to SDCI (measured value of available chlorine 62.0%). In addition to an aqueous solution having a concentration of 120 mg / liter, a disinfectant solution consisting of a weakly acidic aqueous solution having a pH of 4.5, 5.0, and 5.5 was prepared.
The ORP of each sterilizing solution was measured. Table 1 shows the amounts of acidic substances required for the preparation of each disinfectant and the measured ORP.
However, since boric acid has too low a pH lowering ability, 5 g /
Even with the addition amount of liter, the pH cannot be reduced to 5.7 or less,
It was not suitable for preparing a disinfectant solution corresponding to the desired weakly acidic electrolyzed water. The amount of residual chlorine immediately after the preparation of each disinfectant was 74.4 ppm.

[Manufacturing Example 2 of Disinfectant Solution] Tap water is used as dilution water, and citric acid, malic acid, tartaric acid, succinic acid, maleic acid, oxalic acid, glycolic acid (70% aqueous solution), hydrochloric acid are used as acidic substances. (1N aqueous solution), sulfuric acid (1N aqueous solution), sodium hydrogen sulfate, sulfamic acid, and phosphoric acid (85% aqueous solution) were used, and each acidic substance was subjected to SDCI (measured value of effective chlorine amount 62.
0%) of a 120 mg / liter aqueous solution,
Disinfecting solutions composed of weakly acidic aqueous solutions of pH 4.5, 5.0 and 5.5 were each prepared, and the ORP of each disinfecting solution was measured. The results are shown in Table 2 together with the amount of acidic substances required for preparing each disinfectant solution. In addition, the residual chlorine amount immediately after the preparation of each disinfectant solution was 74.4 pp.
m.

[0028]

[Table 1]

[0029]

[Table 2]

From the results shown in Tables 1 and 2, when tap water is used as the dilution water, the required amount of acidic substances is slightly larger than when ion-exchanged water is used. PH4.5 corresponding to the weakly acidic electrolyzed water obtained by the conventional electrolyzed water generator from the acidic substance of
~ 5.5, residual chlorine amount 50 ~ 80ppm, ORP + 80
It turns out that a sterilizing solution of 0 to 1000 mV can be easily prepared. However, sodium dihydrogen phosphate is used in the above P
There is a drawback that the amount of addition required for adjusting to the range of H and ORP is very large, and therefore, it was not used in Production Example 2. The acetic acid and nitric acid used in Production Example 1 were:
Although the use in Production Example 2 is simply omitted, even when tap water is used as dilution water, it can be used without any inconvenience.

[Time-dependent change 1 of disinfectant solution] According to Production Example 1, ion-exchanged water was used as dilution water.
A variety of acidic substances were added to an aqueous solution of DCI at a concentration of 120 mg / liter so that the pH became approximately 5 to prepare a disinfectant solution composed of a weakly acidic aqueous solution. Immediately after the preparation of each disinfectant solution (elapsed time 0), 24 After 72 hours, PH, OR
When the amounts of P and residual chlorine were measured, the results shown in Table 3 were obtained. Similarly, the PH, ORP, and residual chlorine amounts of immediately after and 24 hours after the preparation of each disinfectant prepared using tap water as the dilution water in accordance with Production 2 were measured.
The result shown in FIG.

[0032]

[Table 3]

[0033]

[Table 4]

From the results shown in Table 3, according to the method of the present invention, a weakly acidic sterilizing and disinfecting solution prepared by using the ion exchange water as the dilution water and SDCI as the chlorinating agent to approximately PH5 with various acidic substances was obtained. Even after 72 hours, a pH of 4.5 to 4.5 corresponding to the weakly acidic electrolyzed water obtained by the conventional electrolyzed water generator.
5.5, residual chlorine amount 50-80 ppm, ORP + 800
It is clear that the range of １０００1000 mV is maintained and the storage stability is excellent. Also, from the results in Table 4, in the same manner, the weakly acidic disinfectant prepared at approximately PH5 using tap water as the dilution water tends to have a slightly higher PH when oxalic acid is used as the acidic substance. However, it can be seen that most of them can be used without any trouble as a disinfectant solution showing the same pH, residual chlorine amount and ORP as weakly acidic electrolyzed water by an electrolyzed water generator even 24 hours after preparation.

[Manufacturing Example 3 of Disinfectant Solution] Using ion-exchanged water as dilution water, citric acid, malic acid, tartaric acid, succinic acid, maleic acid, oxalic acid, glycolic acid (70% aqueous solution) Acetic acid,
Hydrochloric acid (1N aqueous solution), sulfuric acid (1N aqueous solution), nitric acid (1N aqueous solution)
Aqueous solution), sodium hydrogen sulfate, sulfamic acid, and phosphoric acid (85% aqueous solution).
In addition to a 60 mg / liter aqueous solution of CI (measured value of available chlorine 62.0%), pH 2.7 and 2.65
Was prepared, and the ORP of each sterilizing solution was measured. The results are shown in Table 5 together with the amount of acidic substances required for preparing each disinfectant solution. In addition, the residual chlorine amount immediately after the preparation of each disinfectant solution,
All were 37.2 ppm.

[Manufacture Example 4 of Disinfectant Solution] Tap water was used as dilution water, and citric acid, malic acid, tartaric acid, succinic acid, maleic acid, oxalic acid, glycolic acid (70% aqueous solution), hydrochloric acid were used as acidic substances. (1N aqueous solution), sulfuric acid (1N aqueous solution), sodium hydrogen sulfate, sulfamic acid, and phosphoric acid (85% aqueous solution) were used, and each acidic substance was subjected to SDCI (measured value of effective chlorine amount 62.
0%) at a concentration of 60 mg / liter,
Disinfecting solutions composed of a strongly acidic aqueous solution of H2.7 and 2.65 were each prepared, and the ORP of each disinfecting solution was measured. The results are shown in Table 5 together with the amount of acidic substances required for preparing each disinfectant solution. The amount of residual chlorine immediately after the preparation of each disinfectant was 37.2 ppm.

[0037]

[Table 5]

From the results shown in Table 5, when inexpensive tap water is used as the dilution water, the required amount of the acidic substance is slightly increased as compared with the case of using ion-exchanged water having a small buffering property. As maleic acid, succinic acid,
By using acetic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and sodium hydrogen sulfate, a pH of 2.7 or less corresponding to strongly acidic electrolyzed water obtained by a conventional electrolyzed water generator, a residual chlorine amount of 30 to 40 ppm, It turns out that a disinfectant solution of ORP + 1100 mV or more can be easily prepared. However, citric acid, malic acid, tartaric acid, oxalic acid,
ORP using glycolic acid or sulfamic acid
Is below +1100 mV, so that it cannot be replaced with strongly acidic electrolyzed water. When the acidic substance is acetic acid, the strongly acidic P
In setting the H range, it is necessary to use a very large amount. Acetic acid and nitric acid used in Production Example 3 were used in Production Example 4
Is simply omitted, but even if tap water is used as dilution water, it can be used without any inconvenience.

[Time-dependent change 2 of disinfectant solution] According to Production Example 3, ion-exchanged water was used as dilution water.
Various acidic substances were added to an aqueous solution of DCI at a concentration of 60 mg / liter so that the pH became about 2.6 to 2.7 to prepare a disinfectant solution composed of a strongly acidic aqueous solution, and immediately after the preparation of each disinfectant solution Time 0) and 24 hours later, PH, ORP,
The amount of residual chlorine was measured. Similarly, in accordance with Production 4, PH, ORP, and residual chlorine amounts were measured immediately after and 24 hours after the preparation of each strongly acidic sterilizing disinfectant prepared using tap water as dilution water. Table 6 shows the results.

[0040]

[Table 6]

From the results shown in Table 6, according to the method of the present invention, PH was adjusted to about 2.6 to 2.7 with various acidic substances using ion-exchanged water or tap water as a dilution water, SDCI as a chlorinating agent. Strongly acidic disinfectants are especially acidic substances, acetic acid,
In the case of hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and sodium hydrogen sulfate, even after 24 hours from the preparation, the pH, the residual chlorine amount, and the ORP are the same as those of the strongly acidic electrolyzed water obtained by the conventional electrolyzed water generator. It can be seen that it can be used without any trouble. However, a strongly acidic aqueous solution using succinic acid, maleic acid, or phosphoric acid as an acidic substance can be said to be desirably used with little time after adjustment because the amount of residual chlorine is greatly reduced with time. Table 6 also shows the change with time when glycolic acid and sulfamic acid are used as the acidic substances for reference. However, these are not suitable as a substitute for strongly acidic electrolyzed water since the ORP of the prepared aqueous solution is lower than +1100 mv. is there.

[Preparation Example 5 of Disinfectant Solution] In addition to using ion-exchanged water as dilution water, tartaric acid and hydrochloric acid (1N aqueous solution) were used as acidic substances, and these acidic substances were treated with sodium hypochlorite (effective chlorine). Quantity 12
%) Of a 600 mg / liter aqueous solution, and P
Disinfectants were prepared from weakly acidic aqueous solutions of H5.5, PH5.0, and PH4.5, respectively.

[Production Example 6 of Disinfectant Solution] Ion-exchanged water was used as dilution water, and malic acid and hydrochloric acid (1N aqueous solution) were used as acidic substances. In addition to a 114 mg / liter aqueous solution (manufactured by Co., Ltd., actual measured amount of chlorine: 63.8%), a sterilizing disinfectant solution containing a weakly acidic aqueous solution having a pH of 5.5, 5.0, or 4.5 was prepared. .

[Manufacturing Example 7 of Disinfectant Solution] In addition to using ion-exchanged water as dilution water, citric acid and hydrochloric acid (1N aqueous solution) were used as acidic substances, and these acidic substances were treated with chloramine T (effective chlorine amount 25%). %) 2
In addition to the 88 mg / liter aqueous solution, the pH was 5.
Disinfectants containing 5, 5.0, and 4.5 weakly acidic aqueous solutions were prepared.

The amount of residual chlorine and ORP immediately after preparation of each of the disinfecting solutions obtained in Production Examples 5 to 7 were measured. The results are shown in Table 7 together with the amount of acidic substance (the amount of hydrochloric acid) required for the preparation of each disinfectant solution.

[0046]

[Table 7]

From the results in Table 7, it can be seen that the use of any of sodium hypochlorite, high-grade powder and chloramine T as the chlorinating agent corresponds to the weakly acidic electrolyzed water obtained by the conventional electrolyzed water generator. PH 4.5-5.5, residual chlorine amount 50
It can be seen that a germicidal disinfectant of 〜80 ppm, ORP + 800-1000 mV can be easily prepared. However, in the preparation of these germicidal disinfectants, the amount of the acidic substance used is larger than when SDCI is used as the chlorine agent. In the case of a germicidal disinfectant using chloramine T, S
The ORP has a lower value as compared with the case where DCI is used.

[Time-dependent change 3 of disinfectant solution] According to Production Examples 5 to 7, ion-exchanged water as diluting water, sodium hypochlorite, high-grade salami powder, chloramine T, citric acid and hydrochloric acid as acidic substances (1N aqueous solution)
Were used, and each acidic substance was added to the aqueous chlorinating agent solution so that the pH became about 5.0 to prepare a disinfecting and disinfecting solution comprising a weakly acidic aqueous solution. Further, using sodium hypochlorite and high-grade salad powder as the chlorine agent and hydrochloric acid (1N aqueous solution) as the acidic substance, the concentration of the aqueous solution of the chlorine agent was measured.
A germicidal disinfectant solution consisting of a strongly acidic aqueous solution having a pH of 2.65 as approximately 1/2 of 6 was prepared. Then, PH, OR immediately after preparation (elapsed time 0) and 24 hours after the preparation of each of these disinfectants.
P and the amount of residual chlorine were measured. Table 8 shows the results.

[0049]

[Table 8]

From the results shown in Table 8, it can be seen that the weakly acidic disinfectant prepared using sodium hypochlorite, high-grade salad powder and chloramine T as the chlorinating agent was the same as the conventional electrolytic solution even after 24 hours from the preparation. It can be seen that a disinfectant solution showing PH, residual chlorine amount, and ORP corresponding to the weakly acidic electrolyzed water obtained by the water generator is maintained. In addition, even with a strongly acidic disinfecting solution prepared using sodium hypochlorite and high-grade salad powder as the chlorine agent, a slight residual chlorine was obtained when the chlorine agent was high-grade salad powder after 24 hours from the preparation. Although the amount is low, it can be seen that properties substantially equivalent to the strongly acidic electrolyzed water obtained by the conventional electrolyzed water generator are maintained. The strongly acidic disinfectant solution having a pH of 2.7 or less, in which the chlorinating agent is chloramine T, was prepared using hydrochloric acid as an acidic substance. However, since the ORP was below +1100 mv and the formation of precipitates was observed, the strong acid was used. It was not suitable as a substitute for electrolyzed water.

[Manufacturing Example 8 of Disinfectant Solution] As shown in Table 9 below, hydrogen peroxide was added to aqueous solutions of SDCI of various concentrations at a SDCI / H ₂ O ₂ molecular ratio of 8/1, 8 /
Each was added at a ratio of 2, 8/3 to prepare each disinfectant solution comprising a weakly acidic aqueous solution. P of these disinfectants
Measure H, ORP, residual chlorine and 140mg
/ L concentration of SD2 aqueous solution with hydrogen peroxide at a molecular ratio of 8/2
Of the disinfecting solution obtained by adding the above at 24 hours and 72 hours after preparation, the results shown in Table 9 were obtained.

[0052]

[Table 9]

From the results shown in Table 9, it can be seen that the pH is lowered by the addition of hydrogen peroxide. This is because one molecule of hydrogen peroxide consumes the chlorine contained in one molecule of SDCI, and hydrochloric acid is generated accordingly. It is thought to be. Thus, PH 4.5 to 5.5 corresponding to weakly acidic electrolyzed water, residual chlorine amount 50
The molecular ratio of SDCI / H ₂ O ₂ is 4/1 in order to make a weakly acidic aqueous solution of ８０80 ppm, ORP + 800-1000 mV, and to reduce the consumption of SDCI by hydrogen peroxide.
Near is preferred. In addition, from the time-dependent change shown in Table 9, even a weakly acidic disinfectant obtained by adjusting the pH with hydrogen peroxide can be obtained with a conventional electrolyzed water generator even after 72 hours from its preparation. It can be seen that properties equivalent to the weakly acidic electrolyzed water are maintained, and excellent storage stability is provided.

[Sterilization / Disinfection Test 1] A germicidal / sterilization solution of pH 5.0 prepared in Production Example 1 (see Table 1, 15 kinds excluding those in which the acidic substance is boric acid), and ion exchange water was used in Production Example 3. PH 2.65, O prepared
RP + 1100 mv or more disinfectant (see Table 5 ... 8)
Seeds), a disinfectant of pH 5.0 prepared in Production Examples 5 to 7 (see Table 7 ... 6 types), and a disinfectant of PH 2.65 used in the section of time-dependent change 3 of disinfectants (see Table 8) ... 2 types), and a sterilization disinfectant solution (see Table 9 ... 1 type) obtained by adding hydrogen peroxide to a 140 mg / l aqueous solution of SDCI at a molecular ratio of 8/2 in Production Example 8; 1 ml of each of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa bacteria (approximately 10 ⁶ cells / ml) was added to each test tube, and shaked for 1 minute. Was collected and applied to the entire surface of a Petri dish medium, and cultured at 37 ° C. for 24 hours. Observation of the surfaces of these media revealed that no colonies were generated.
In addition, SCDLP for preservative-inactivated viable cell count measurement was used in the medium.
An agar medium "Daigo" was used.

[Disinfection test 2] The disinfection solution of pH 5.0 prepared in Production Example 1 (see Table 1, 15 kinds excluding those in which the acidic substance is boric acid) was applied to the floor of the hospital room by a height of 20 cm. After 5 minutes, the center of each sprayed surface was stamped with a food stamp for general bacteria, and cultivation was performed at 37 ° C. for 2 days. As a result, colonies were formed on the floor surface which was not sprayed with the disinfectant solution in the same manner, but colonies were not found on any of the stamped floor surfaces.

[Effect Test on Dental Impression Material] Three kinds of disinfectants of PH 5.0 prepared by adding citric acid, succinic acid and sodium dihydrogen phosphate to the aqueous solution of 120 mg / l SDCI in Production Example 1 respectively. In Production Example 3, 6
Maleic acid, glycolic acid and sodium bisulfate were added to a 0 mg / l SDCI aqueous solution, and three kinds of disinfecting solutions of PH 2.65 prepared using tap water as dilution water, and 140 mg / l concentration in Production Example 8 SD
Using a disinfectant solution obtained by adding hydrogen peroxide to a CI aqueous solution at a molecular ratio of 8/2, an alginate impression material (diameter 25 mm) used for obtaining a patient's tooth shape in dentistry was used in each solution. , 10 mm in height) was immersed for 30 minutes, and the change in diameter was measured. The alginate impression material after the immersion was transferred to a gypsum impression, and after 40 minutes, the alginate impression material was removed and the state of the gypsum surface was examined. The results are shown in Table 10 together with the results of immersion in tap water instead of the sterilizing solution.

[0057]

[Table 10]

From the results in Table 10, it can be seen that the disinfectants and disinfectants according to the method of the present invention show little change in shape due to the immersion of the alginate impression material, and the gypsum surface except for those using sodium dihydrogen phosphate as the acidic substance. Since there is no roughness, it can be seen that the tooth impression can be suitably used for sterilization of the dental impression material after obtaining the impression.

[Applicability test for disinfection washing of artificial dialysis line] A sterilization disinfectant solution of PH 5.0 prepared by adding citric acid to a 120 mg / l SDCI aqueous solution in Production Example 1, 140 mg / L in Production Example 8 Disinfectant obtained by adding hydrogen peroxide to a concentrated aqueous solution of SDCI at a molecular ratio of 8/2, SD
Using a 130 mg / l aqueous solution of CI alone as a disinfecting and washing test solution, dialysate was dropped on a stainless steel plate at a volume of 10 μl, 25 μl, and 50 μl, respectively.
A required number of samples that have been air-dried for a certain time are prepared, and these samples are immersed in each of the above test solutions, pulled up every 30 minutes, and placed on a plate by the OCPC method (orthocresol phthalein complexone method). By determining whether or not calcium remained, the immersion time (in units of 30 minutes) required for removing calcium was examined. Table 11 shows the results.
Shown in

[0060]

[Table 11]

From the results shown in Table 11, the weakly acidic disinfectant obtained by using the SDCI as the chlorinating agent in the method of the present invention can remove calcium carbonate precipitated from the dialysate, and is used for disinfection and cleaning of the artificial dialysis line. It turns out that it can be used conveniently. In addition, as a result of conducting a similar applicability test for disinfection and cleaning of the artificial dialysis line for a strongly acidic disinfectant solution,
Calcium removal was higher than in the case of weak acid, and complete removal was possible within 30 minutes. Therefore, when the artificial dialysis line is to be used for disinfecting and cleaning as described above, one of the sterilizing and disinfecting solutions must be prepared in advance.
A concentrated solution having a concentration of about 5 to 50 times may be prepared, and may be diluted to a required concentration for disinfecting and washing.

[0062]

According to the first aspect of the present invention, it has the same performance and properties as the acidic electrolyzed water generated by the conventional electrolysis of salt water, and is particularly useful especially in the stability of residual chlorine. It is possible to easily and inexpensively obtain a highly disinfectant solution without using expensive equipment such as an electrolyzed water generator.

According to the second aspect of the present invention, it is possible to prepare, as the above-mentioned germicidal disinfecting solution, a solution corresponding to weakly acidic electrolyzed water generated by conventional electrolysis of saline.

According to the third aspect of the present invention, the above-mentioned disinfectant can be reliably and easily prepared as a solution corresponding to a weakly acidic electrolyzed water obtained by electrolysis of a conventional saline solution.

According to the fourth aspect of the present invention, it is possible to prepare, as the above-mentioned germicidal disinfecting solution, a solution corresponding to strongly acidic electrolyzed water generated by conventional electrolysis of saline.

According to the fifth aspect of the present invention, the above-mentioned sterilizing and disinfecting solution can be reliably and easily prepared as a solution corresponding to conventional strongly acidic electrolyzed water obtained by electrolysis of a saline solution.

[Brief description of the drawings]

FIG. 1 is a correlation diagram of redox potential and PH showing a living sphere of a microorganism.

FIG. 2 is a correlation diagram between effective chlorine abundance ratio and PH showing a change in the form of available chlorine in water.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-8-168774 (JP, A) JP-A-2-131409 (JP, A) JP-A-63-267708 (JP, A) JP-A-53-167 148844 (JP, A) JP-A-52-123399 (JP, A) JP-A-61-165309 (JP, A) JP-A-54-140718 (JP, A) JP-T-61-501495 (JP, A) (58) Field surveyed (Int.Cl. ⁷ , DB name) A01N 59/08 A01N 25/00 101 A61L 2/18 A01N 41/06 A01N 43/64 105

Claims (5)

(57) [Claims] To 1. A water, a) and dichloro isocyanuric acid <br/> sodium, b) by dissolving the acidic material or hydrogen peroxide, pH 5.5 or less, residual chlorine content 30ppm
As described above, a method for producing a disinfecting and disinfecting solution, comprising preparing an acidic aqueous solution having an oxidation-reduction potential of +800 mV or more. 2. An acidic aqueous solution having a pH of 4.5 to 5.5 and a residual pH of 5.5.
Distilled chlorine amount 50-80 ppm, oxidation-reduction potential + 800-1
Method for producing a disinfectant according to claim 1, wherein you prepared 000MV. 3. The method according to claim 1, wherein the component (b) is citric acid, malic acid,
Tartaric acid, maleic acid, succinic acid, oxalic acid, glycol
Acid, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, sodium hydrogen sulfate,
At least one acid selected from rufamic acid and phosphoric acid
3. The method for producing a disinfectant / disinfectant according to claim 2 , wherein the disinfectant is hydrogen peroxide . 4. An acidic aqueous solution having a pH of 2.7 or less and a residual salt
Elemental amount 30-40ppm, redox potential + 1100mV or less
Method for producing a disinfectant according to claim 1, wherein you prepared above. 5. The method according to claim 1, wherein the component (b) is maleic acid or succinic acid.
Acid, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, sodium hydrogen sulfate
At least one acidic substance der Ru claim 4 manufacturing method of disinfectant according selected from um.