CN104068288B - A kind of feed additive of anti-lithangiuria - Google Patents
A kind of feed additive of anti-lithangiuria Download PDFInfo
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- CN104068288B CN104068288B CN201410358293.0A CN201410358293A CN104068288B CN 104068288 B CN104068288 B CN 104068288B CN 201410358293 A CN201410358293 A CN 201410358293A CN 104068288 B CN104068288 B CN 104068288B
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- CN
- China
- Prior art keywords
- lithangiuria
- feed additive
- calculus
- lactasinum
- allopurinol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003674 animal food additive Substances 0.000 title claims abstract description 23
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003459 allopurinol Drugs 0.000 claims abstract description 12
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003199 etacrynic acid Drugs 0.000 claims abstract description 12
- 229960005336 magnesium citrate Drugs 0.000 claims abstract description 12
- 239000004337 magnesium citrate Substances 0.000 claims abstract description 12
- 235000002538 magnesium citrate Nutrition 0.000 claims abstract description 12
- 229960000206 potassium canrenoate Drugs 0.000 claims abstract description 12
- JTZQCHFUGHIPDF-RYVBEKKQSA-M potassium canrenoate Chemical compound [K+].O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)CCC([O-])=O)[C@@H]4[C@@H]3C=CC2=C1 JTZQCHFUGHIPDF-RYVBEKKQSA-M 0.000 claims abstract description 12
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 abstract description 10
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 238000007599 discharging Methods 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 2
- 241000282326 Felis catus Species 0.000 description 25
- 210000002700 urine Anatomy 0.000 description 18
- 230000001737 promoting effect Effects 0.000 description 8
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 7
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 7
- 229940116269 uric acid Drugs 0.000 description 7
- 208000019901 Anxiety disease Diseases 0.000 description 6
- 230000036506 anxiety Effects 0.000 description 6
- 235000014590 basal diet Nutrition 0.000 description 6
- 230000029087 digestion Effects 0.000 description 5
- 230000027939 micturition Effects 0.000 description 5
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 208000009911 Urinary Calculi Diseases 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 208000010717 cat disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 101100381997 Danio rerio tbc1d32 gene Proteins 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- 101100381999 Mus musculus Tbc1d32 gene Proteins 0.000 description 2
- 241000009328 Perro Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 2
- 239000001354 calcium citrate Substances 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 239000008157 edible vegetable oil Substances 0.000 description 2
- 230000008451 emotion Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000005713 exacerbation Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000013337 tricalcium citrate Nutrition 0.000 description 2
- 229940075420 xanthine Drugs 0.000 description 2
- CJRJTCMSQLEPFQ-UHFFFAOYSA-N 6-cat Chemical compound ClC1=CC=C2CC(N)CCC2=C1 CJRJTCMSQLEPFQ-UHFFFAOYSA-N 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940036811 bone meal Drugs 0.000 description 1
- 239000002374 bone meal Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses the feed additive of a kind of anti-lithangiuria, belong to field of feed additive technology.It is characterized in that weight percentage is made up of following component: allopurinol 15 30%, lactasinum 35 50%, magnesium citrate 20 40%, etacrynic acid 0.2 1%, canrenoate potassium 0.5 3%.The present invention provides the feed additive of a kind of anti-lithangiuria, adds in daily feedstuff, has rapid solution lithangiuria, the effect preventing the formation of lithangiuria, promotion calculus from discharging.
Description
Technical field
The present invention relates to a kind of feed for pet additive, specifically, relate to the feed additive of a kind of anti-lithangiuria.
Background technology
Now dog, cat have all been supported as house pet by a lot of families, and dog cat urinary stone disease often annoyings love and dotes on personage.Urinary stone disease is to be separated out by the uric acid in urine and inorganic salts to form calculus, causes urinary tract mucosa inflammation, the hemorrhage and disease of dysuria.Dog, cat have a lot of behavior expression after suffering from urinary stone, including frequently going to toilet, each urine volume is few, and the when of urine, more painful needs are posed for a long time, can often lick privates with color, usually feel bad in urine, especially front and back compare anxiety going to toilet.Calculus can block the urethra of dog, cat, dog, cat is caused to close urine, when this occurs, need to ask doctor be dog, cat urethral catheterization to pet clinic at once, because not urinating and can cause renal failure for 12 hours, within 18 hours, do not urinate and there will be uremia, the most probably bladder was suppressed more than 24 hours quick-fried, cause massive hemorrhage dead.At present lithangiuria is all used operation and medication treatment, the feed additive of lithangiuria can be prevented and treated almost without, it is therefore desirable to a kind of feed additive, add in daily feedstuff, prevent from forming lithangiuria, promoting to discharge lithangiuria, make pet health grow.
Summary of the invention
It is an object of the invention to provide the feed additive of a kind of anti-lithangiuria, there is the formation preventing lithangiuria, the effect promoting calculus to discharge, and can be with digestion promoting, beneficially pet health growth.
The technical scheme is that
The feed additive of a kind of anti-lithangiuria, weight percentage is made up of following component: allopurinol 15-30%, lactasinum 35-50%, magnesium citrate 20-40%, etacrynic acid 0.2-1%, canrenoate potassium 0.5-3%.
Allopurinol is xanthine oxidase inhibitor, blocks hypoxanthine to xanthine and xanthine to the conversion process of uric acid, ultimately results in uricopoiesis and reduces.Lactasinum for enteral abnormal fermentation, promotes that excretion is conducive to discharging calculus, prevents calculus to be gathered in internal in this formula, beneficially pet health growth.Magnesium citrate provides citrate ion and magnesium ion, citrate ion is the strongest a kind of calcium ion chelator, itself and calcium ion form calcium citrate stable and soluble in water and discharge from urine, and magnesium ion can suppress calcium ion to assemble simultaneously, prevents calcium calculus from growing.Etacrynic acid is quick diuretic, it is possible to quickly play diuretic effect, accelerates uric acid and calculus is discharged, and absorbed following oral administration is rapid, and appearance effect in 30 minutes reaches summit in about 2 hours, continues 6～8 hours.Canrenoate potassium has chronic diuresis, and soft promote uric acid and calculus are discharged.This formula compatibility is reasonable, and each component complements each other, and promotes that curative effect plays.
The invention has the beneficial effects as follows: by stoping the formation of uric acid, suppression calcium ion is assembled, prevented calcium calculus from growing, and fundamentally solves the formation of lithangiuria, can the most thoroughly solve lithangiuria；By litholysis being become calcium citrate, simultaneously digestion promoting and excretion, accelerating uric acid and calculus is discharged, there is rapid solution lithangiuria, the effect promoting calculus to discharge, arrive the effect for the treatment of lithangiuria, the lithangiuria that can have been formed with fast treating；Diuresis rate is fast, quickly alleviates and suppresses urine symptom, alleviates house pet misery, accelerates the discharge of calculus, and lithagogue effect is rapid；Having chronic diuresis, soft promote uric acid and calculus are discharged, and anti-calculus and row's calculus effect are permanently effective；The present invention can add in daily feedstuff, uses at any time, easy to use；Can be with digestion promoting and excretion, beneficially pet health growth.
Detailed description of the invention
In order to better illustrate the present invention, it is simple to understand technical scheme, the typical but non-limiting embodiment of the present invention is as follows:
Embodiment one
The feed additive of a kind of anti-lithangiuria, by weight percentage composition are made up of following component: allopurinol 28%, lactasinum 40%, magnesium citrate 31%, etacrynic acid 0.4%, canrenoate potassium 0.6%.
Embodiment two
The feed additive of a kind of anti-lithangiuria, by weight percentage composition are made up of following component: allopurinol 17%, lactasinum 48%, magnesium citrate 33%, etacrynic acid 1%, canrenoate potassium 1%.
Embodiment three
The feed additive of a kind of anti-lithangiuria, by weight percentage composition are made up of following component: allopurinol 26%, lactasinum 50%, magnesium citrate 21%, etacrynic acid 0.5%, canrenoate potassium 2.5%.
Embodiment four
The feed additive of a kind of anti-lithangiuria, by weight percentage composition are made up of following component: allopurinol 21.5%, lactasinum 35%, magnesium citrate 40%, etacrynic acid 0.7%, canrenoate potassium 2.8%.
The present invention has carried out contrast test to pet cat,
Test one: select 20 and suffer from the cat having urinary stone disease, according to the principle that body weight, the state of an illness are similar with sex ratio, being divided into matched group and test group (often group 10), control group fed basal diet, test group feeds the feed additive of the anti-lithangiuria of basal diet+embodiment four preparation；The feed additive 3g of the anti-lithangiuria of every cat feeding every day embodiment four preparation;The formula of basal diet is: casein 50g, milk powder 50g, Hepar Bovis seu Bubali 200g, meat 200g, Herba bromi japonici 300g, edible oil 50g.
After feeding 1 day, the voided volume of all cats of test group the most substantially increases, and the matched group state of an illness is still；After feeding 2 days, test group all cats frequent micturition reduces, and each voided volume increases, and discharges fine particle with urine, and the matched group state of an illness is still；After feeding 3 days, test group all cats need not pose for a long time when urinating, and no longer licks privates, is emotionally stable, and discharges fine particle with urine, and still, sb.'s illness took a turn for the worse separately 4, band blood in urine, anxiety for 6 cat disease feelings of matched group；After feeding 5 days, all cats of test group, it is completely recovered to normal condition, appetite increases, active spiritedness, still, 4 cats are in a bad way 4 cat disease feelings of matched group, and in urine, color increases, emotion very anxiety, separately has 2 cat disease feelings severe exacerbations, it is impossible to urinate, promptly send doctor to carry out urethral catheterization.Illustrate that the present invention has the effect quickly discharging calculus, and can be with digestion promoting, beneficially pet health growth.
Test two: select 40 healthy cats, according to the principle that body weight is similar with sex ratio, being divided into matched group and test group (often group 20), control group fed basal diet, test group feeds the feed additive of the anti-lithangiuria of basal diet+embodiment four preparation；The feed additive 2g of the anti-lithangiuria of every cat feeding every day embodiment four preparation;The formula of basal diet is: casein 50g, milk powder 50g, Hepar Bovis seu Bubali 100g, meat 400g, Herba bromi japonici 300g, edible oil 50g, bone meal 200g, calcium chloride 20g.
After feeding 30 days, all cats of test group are healthy, without exception, and matched group has 3 cats frequent micturition occur, and urine volume is few；After feeding 60 days, all cats of test group are healthy, and appetite increases, and the most active, matched group has 5 cats frequent micturition occur, and urine volume is few, separately have band blood in 3 cat urine, anxiety；After feeding 90 days, all cats of test group are healthy, and appetite increases, and active spiritedness, fur is smooth, and frequent micturition occur in 11 cats of matched group, and urine volume is few, and sb.'s illness took a turn for the worse separately 4, band blood in urine, anxiety；After feeding 120 days, all cats of test group are healthy, and appetite increases, active spiritedness, and fur is smooth, there is frequent micturition in 11 cats of matched group, and urine volume is few, and sb.'s illness took a turn for the worse separately 6, and in urine, color increases, emotion very anxiety, separately has 2 cat disease feelings severe exacerbations, it is impossible to urinate, promptly send doctor to carry out urethral catheterization.Illustrate that the present invention has the effect preventing forming lithangiuria, and can be with digestion promoting, beneficially pet health growth.
Claims (5)
1. the feed additive of an anti-lithangiuria, it is characterised in that weight percentage is made up of following component: allopurinol 15-30%, lactasinum 35-50%, magnesium citrate 20-40%, etacrynic acid 0.2-1%, canrenoate potassium 0.5-3%.
The feed additive of a kind of anti-lithangiuria the most as claimed in claim 1, it is characterised in that percentage composition by weight is made up of following component: allopurinol 28%, lactasinum 40%, magnesium citrate 31%, etacrynic acid 0.4%, canrenoate potassium 0.6%.
The feed additive of a kind of anti-lithangiuria the most as claimed in claim 1, it is characterised in that percentage composition by weight is made up of following component: allopurinol 17%, lactasinum 48%, magnesium citrate 33%, etacrynic acid 1%, canrenoate potassium 1%.
The feed additive of a kind of anti-lithangiuria the most as claimed in claim 1, it is characterised in that percentage composition by weight is made up of following component: allopurinol 26%, lactasinum 50%, magnesium citrate 21%, etacrynic acid 0.5%, canrenoate potassium 2.5%.
The feed additive of a kind of anti-lithangiuria the most as claimed in claim 1, it is characterised in that percentage composition by weight is made up of following component: allopurinol 21.5%, lactasinum 35%, magnesium citrate 40%, etacrynic acid 0.7%, canrenoate potassium 2.8%.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410358293.0A CN104068288B (en) | 2014-07-25 | 2014-07-25 | A kind of feed additive of anti-lithangiuria |
| CN201610434844.6A CN106036135A (en) | 2014-07-25 | 2014-07-25 | Medicine, composition and veterinary medicine for preventing calculus and fast discharging calculus |
| CN201610434849.9A CN105851522A (en) | 2014-07-25 | 2014-07-25 | Feed for preventing lithangiuria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410358293.0A CN104068288B (en) | 2014-07-25 | 2014-07-25 | A kind of feed additive of anti-lithangiuria |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610434844.6A Division CN106036135A (en) | 2014-07-25 | 2014-07-25 | Medicine, composition and veterinary medicine for preventing calculus and fast discharging calculus |
| CN201610434849.9A Division CN105851522A (en) | 2014-07-25 | 2014-07-25 | Feed for preventing lithangiuria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104068288A CN104068288A (en) | 2014-10-01 |
| CN104068288B true CN104068288B (en) | 2016-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610434844.6A Pending CN106036135A (en) | 2014-07-25 | 2014-07-25 | Medicine, composition and veterinary medicine for preventing calculus and fast discharging calculus |
| CN201610434849.9A Pending CN105851522A (en) | 2014-07-25 | 2014-07-25 | Feed for preventing lithangiuria |
| CN201410358293.0A Expired - Fee Related CN104068288B (en) | 2014-07-25 | 2014-07-25 | A kind of feed additive of anti-lithangiuria |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610434844.6A Pending CN106036135A (en) | 2014-07-25 | 2014-07-25 | Medicine, composition and veterinary medicine for preventing calculus and fast discharging calculus |
| CN201610434849.9A Pending CN105851522A (en) | 2014-07-25 | 2014-07-25 | Feed for preventing lithangiuria |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106819506A (en) * | 2016-12-29 | 2017-06-13 | 新昌县拜瑞珂生物技术有限公司 | A kind of feed addictive of anti-lithangiuria |
| CN111418558B (en) * | 2019-09-22 | 2021-09-28 | 山西大学 | Construction method of ablation metabolic urinary calculus animal model |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI280136B (en) * | 2003-05-30 | 2007-05-01 | Lytone Enterprise Inc | Composition containing dipeptide of histidine and alanine for reducing uric acid |
| CN101006996A (en) * | 2006-01-25 | 2007-08-01 | 盛骝吾 | Medicine for treating urinary system calculus and hyperuricemia and preparation method thereof |
| DE102006027794A1 (en) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antihypertensive combination wafer |
| NZ585583A (en) * | 2007-11-27 | 2011-09-30 | Ardea Biosciences Inc | Novel compounds and compositions and methods of use |
| CN101664413A (en) * | 2008-09-02 | 2010-03-10 | 天津生机集团股份有限公司 | Medicinal health agent for preventing and treating canine/feline magnesium ammonium phosphate stones |
| BR112014010693A2 (en) * | 2011-11-04 | 2020-11-10 | Cymabay Therapeutics, Inc. | use of a compound for the preparation of a pharmaceutical composition for the treatment of gout in subpopulations of patients |
-
2014
- 2014-07-25 CN CN201610434844.6A patent/CN106036135A/en active Pending
- 2014-07-25 CN CN201610434849.9A patent/CN105851522A/en active Pending
- 2014-07-25 CN CN201410358293.0A patent/CN104068288B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN106036135A (en) | 2016-10-26 |
| CN104068288A (en) | 2014-10-01 |
| CN105851522A (en) | 2016-08-17 |
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