CN104066435A - 蛋白水解抗性的氢键替代螺旋 - Google Patents

蛋白水解抗性的氢键替代螺旋 Download PDF

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Publication number
CN104066435A
CN104066435A CN201280067761.8A CN201280067761A CN104066435A CN 104066435 A CN104066435 A CN 104066435A CN 201280067761 A CN201280067761 A CN 201280067761A CN 104066435 A CN104066435 A CN 104066435A
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CN
China
Prior art keywords
peptide
aryl
alkyl
heteroaryl
formula
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Pending
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CN201280067761.8A
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English (en)
Chinese (zh)
Inventor
P·S·阿罗拉
A·帕吉瑞
S·乔伊
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New York University NYU
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New York University NYU
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Publication of CN104066435A publication Critical patent/CN104066435A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280067761.8A 2011-12-21 2012-12-21 蛋白水解抗性的氢键替代螺旋 Pending CN104066435A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161578652P 2011-12-21 2011-12-21
US201161578646P 2011-12-21 2011-12-21
US61/578,646 2011-12-21
US61/578,652 2011-12-21
PCT/US2012/071223 WO2013096755A1 (en) 2011-12-21 2012-12-21 Proteolytically resistant hydrogen bond surrogate helices

Publications (1)

Publication Number Publication Date
CN104066435A true CN104066435A (zh) 2014-09-24

Family

ID=48669532

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280067761.8A Pending CN104066435A (zh) 2011-12-21 2012-12-21 蛋白水解抗性的氢键替代螺旋

Country Status (6)

Country Link
US (1) US9376469B2 (https=)
EP (1) EP2793920A4 (https=)
JP (1) JP2015504048A (https=)
CN (1) CN104066435A (https=)
CA (1) CA2895930A1 (https=)
WO (1) WO2013096755A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108024987A (zh) * 2014-10-10 2018-05-11 德玛医药 用于治疗癌症的二去水卫矛醇的类似物或衍生物与含铂抗肿瘤药物的组合
CN111417656A (zh) * 2017-08-23 2020-07-14 西卡肿瘤解决方案有限公司 细胞膜穿透缀合物

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103889437A (zh) * 2011-08-31 2014-06-25 纽约大学 硫醚、醚和烷基胺连接的氢键替代物肽模拟物
US20140205681A1 (en) * 2013-01-19 2014-07-24 New York University HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION
US20150065436A1 (en) * 2013-09-03 2015-03-05 University Of Southern California INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES
US20170066801A1 (en) * 2014-02-22 2017-03-09 New York University Alpha3beta hydrogen bond surrogate macrocycles as modulators of ras
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
JP7561364B2 (ja) * 2020-04-30 2024-10-04 国立大学法人東北大学 蛍光偏光免疫分析法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100228004A1 (en) * 2009-03-06 2010-09-09 Prabhakaran Erode N Templates for nucleation and propagation of peptide secondary structure
US20100234563A1 (en) * 2004-05-27 2010-09-16 Paramjit Arora Methods for Preparing Internally Constrained Peptides and Peptidomimetics
US20110059161A1 (en) * 2009-09-03 2011-03-10 Gradalis, Inc. Targeted delivery using tissue-specific peptidomimetic ligands

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592377B2 (en) * 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2010033879A2 (en) 2008-09-18 2010-03-25 New York University Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices
BRPI0920889A2 (pt) * 2008-09-22 2017-10-10 Aileron Therapeutics Inc macrociclos peptidomiméticos.
ES2586411T3 (es) 2011-03-04 2016-10-14 New York University Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras
CN103889437A (zh) 2011-08-31 2014-06-25 纽约大学 硫醚、醚和烷基胺连接的氢键替代物肽模拟物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100234563A1 (en) * 2004-05-27 2010-09-16 Paramjit Arora Methods for Preparing Internally Constrained Peptides and Peptidomimetics
US20100228004A1 (en) * 2009-03-06 2010-09-09 Prabhakaran Erode N Templates for nucleation and propagation of peptide secondary structure
US20110059161A1 (en) * 2009-09-03 2011-03-10 Gradalis, Inc. Targeted delivery using tissue-specific peptidomimetic ligands

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108024987A (zh) * 2014-10-10 2018-05-11 德玛医药 用于治疗癌症的二去水卫矛醇的类似物或衍生物与含铂抗肿瘤药物的组合
CN111417656A (zh) * 2017-08-23 2020-07-14 西卡肿瘤解决方案有限公司 细胞膜穿透缀合物

Also Published As

Publication number Publication date
CA2895930A1 (en) 2013-06-27
JP2015504048A (ja) 2015-02-05
EP2793920A1 (en) 2014-10-29
US9376469B2 (en) 2016-06-28
WO2013096755A1 (en) 2013-06-27
EP2793920A4 (en) 2015-07-01
US20130210144A1 (en) 2013-08-15

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Application publication date: 20140924