CA2895930A1 - Proteolytically resistant hydrogen bond surrogate helices - Google Patents
Proteolytically resistant hydrogen bond surrogate helices Download PDFInfo
- Publication number
- CA2895930A1 CA2895930A1 CA2895930A CA2895930A CA2895930A1 CA 2895930 A1 CA2895930 A1 CA 2895930A1 CA 2895930 A CA2895930 A CA 2895930A CA 2895930 A CA2895930 A CA 2895930A CA 2895930 A1 CA2895930 A1 CA 2895930A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- amino acid
- moiety
- heteroaryl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578652P | 2011-12-21 | 2011-12-21 | |
| US201161578646P | 2011-12-21 | 2011-12-21 | |
| US61/578,646 | 2011-12-21 | ||
| US61/578,652 | 2011-12-21 | ||
| PCT/US2012/071223 WO2013096755A1 (en) | 2011-12-21 | 2012-12-21 | Proteolytically resistant hydrogen bond surrogate helices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2895930A1 true CA2895930A1 (en) | 2013-06-27 |
Family
ID=48669532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2895930A Abandoned CA2895930A1 (en) | 2011-12-21 | 2012-12-21 | Proteolytically resistant hydrogen bond surrogate helices |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9376469B2 (https=) |
| EP (1) | EP2793920A4 (https=) |
| JP (1) | JP2015504048A (https=) |
| CN (1) | CN104066435A (https=) |
| CA (1) | CA2895930A1 (https=) |
| WO (1) | WO2013096755A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889437A (zh) * | 2011-08-31 | 2014-06-25 | 纽约大学 | 硫醚、醚和烷基胺连接的氢键替代物肽模拟物 |
| US20140205681A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION |
| US20150065436A1 (en) * | 2013-09-03 | 2015-03-05 | University Of Southern California | INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES |
| US20170066801A1 (en) * | 2014-02-22 | 2017-03-09 | New York University | Alpha3beta hydrogen bond surrogate macrocycles as modulators of ras |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| CN108024987A (zh) * | 2014-10-10 | 2018-05-11 | 德玛医药 | 用于治疗癌症的二去水卫矛醇的类似物或衍生物与含铂抗肿瘤药物的组合 |
| US11583589B2 (en) * | 2017-08-23 | 2023-02-21 | Cygenica Limited | Cell membrane penetrating conjugates |
| JP7561364B2 (ja) * | 2020-04-30 | 2024-10-04 | 国立大学法人東北大学 | 蛍光偏光免疫分析法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7202332B2 (en) | 2004-05-27 | 2007-04-10 | New York University | Methods for preparing internally constrained peptides and peptidomimetics |
| US8592377B2 (en) * | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2010033879A2 (en) | 2008-09-18 | 2010-03-25 | New York University | Inhibiting interaction between hif-1a and p300/cbp with hydrogen bond surrogate-based helices |
| BRPI0920889A2 (pt) * | 2008-09-22 | 2017-10-10 | Aileron Therapeutics Inc | macrociclos peptidomiméticos. |
| US8835602B2 (en) * | 2009-03-06 | 2014-09-16 | Indian Institute Of Science | Templates for nucleation and propagation of peptide secondary structure |
| CA2772057C (en) * | 2009-09-03 | 2016-02-02 | Strike Bio, Inc. | Targeted delivery using tissue-specific peptidomimetic ligands |
| ES2586411T3 (es) | 2011-03-04 | 2016-10-14 | New York University | Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras |
| CN103889437A (zh) | 2011-08-31 | 2014-06-25 | 纽约大学 | 硫醚、醚和烷基胺连接的氢键替代物肽模拟物 |
-
2012
- 2012-12-21 US US13/724,887 patent/US9376469B2/en active Active
- 2012-12-21 CN CN201280067761.8A patent/CN104066435A/zh active Pending
- 2012-12-21 WO PCT/US2012/071223 patent/WO2013096755A1/en not_active Ceased
- 2012-12-21 JP JP2014548945A patent/JP2015504048A/ja active Pending
- 2012-12-21 CA CA2895930A patent/CA2895930A1/en not_active Abandoned
- 2012-12-21 EP EP12859663.2A patent/EP2793920A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015504048A (ja) | 2015-02-05 |
| EP2793920A1 (en) | 2014-10-29 |
| US9376469B2 (en) | 2016-06-28 |
| WO2013096755A1 (en) | 2013-06-27 |
| EP2793920A4 (en) | 2015-07-01 |
| US20130210144A1 (en) | 2013-08-15 |
| CN104066435A (zh) | 2014-09-24 |
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