CN104056171A - 治疗小儿疳积的中药 - Google Patents
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Abstract
本发明涉及一种药物配方领域，具体地说是一种治疗小儿疳积的中药，其特征在于由如下重量份的原料药制成，山栀子8-10份，使君子5-8份，鸡屎藤17-20份，黄芪10-14份，白蔻5-8份，苦楝子10-14份，草决明6-8份，莱菔子7-13份，紫苏7-10份，三棱5-8份，辛荑4-7份，石斛4-8份，半枝莲2-7份，银柴胡18-25份，陈皮4-5份，白芥子4-5份，将上述原料药混合后用水浸泡，煎熬后去渣得滤液。本发明具有疗效显著、无毒副作用、适宜儿童服用的特点，并且它采用较为常见的中药材作为原料，成本低廉。
Description
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗小儿疳积的中药。
背景技术
众所周知，疳积是小儿时期，尤其是1～5岁儿童的一种常见病证。是指由于喂养不当，或由多种疾病的影响，使脾胃受损而导致全身虚弱、消瘦面黄、发枯等慢性病证。疳积是疳症和积滞的总称。疳症是指由喂养不当，脾胃受伤，影响生长发育的病症，相当于营养障碍的慢性疾病。积滞是由乳食内积，脾胃受损而引起的肠胃疾病，临床以腹泻或便秘、呕吐、腹胀为主要症状。古人有“无积不成疳”、“积为疳之母”的说法。
小儿疳积的病因：1、乳食不节，伤及脾胃。乳食不节，过食肥甘生冷，伤及脾胃，脾胃失司，受纳运化失职，升降不调，及成积滞。积滞日久，脾胃更伤，转化为疳；2、脾胃虚寒薄弱。脾胃虚寒薄弱，则乳食难于腐熟，而使乳食停积，壅聚中州，阻碍气机，时日渐久，致使营养失调，患儿赢瘦，气液虚衰，发育障碍。乳食不节与脾胃虚弱互为因果，积滞可伤及脾胃，脾胃虚弱又能产生积滞，临床上多互相兼杂为病；3、其他。某些慢性疾病和感染虫症也常为本病的原因。中医指小儿面黄肌瘦，腹部膨大的病，多由饮食，没有节制或腹内有寄生虫引起。
发明内容
本发明的目的就是为了克服上述现有的技术不足，提供一种治疗小儿疳积的中药，具有疗效显著、无毒副作用、适宜儿童服用的特点，并且它采用较为常见的中药材作为原料，成本低廉。
本发明解决上述技术问题采用的技术方案是：一种治疗小儿疳积的中药，其特征在于由如下重量份的原料药制成，山栀子8-10份，使君子5-8份，鸡屎藤17-20份，黄芪10-14份，白蔻5-8份，苦楝子10-14份，草决明6-8份，莱菔子7-13份，紫苏7-10份，三棱5-8份，辛荑4-7份，石斛4-8份，半枝莲2-7份，银柴胡18-25份，陈皮4-5份，白芥子4-5份，将上述原料药混合后用水浸泡，煎熬后去渣得滤液。
本发明的有益效果是，具有疗效显著、无毒副作用、适宜儿童服用的特点，并且它采用较为常见的中药材作为原料，成本低廉。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：本实施例采用山栀子、使君子、鸡屎藤、黄芪、白蔻、苦楝子、草决明、莱菔子、紫苏、三棱、辛荑、石斛、半枝莲、银柴胡、陈皮、白芥子为原料药制备而成。其原料药组成(重量份)每服为山栀子9、使君子6、鸡屎藤18、黄芪12、白蔻6、苦楝子12、草决明7、莱菔子12、紫苏8、三棱6、辛荑6、石斛5、半枝莲4、银柴胡20、陈皮4、白芥子4。取上述16种原料药，总质量为250g，在室温下将16种中草药加水至900-1000ml，浸泡4小时，然后用武火煮沸文火煎熬至100-120分钟左右，去渣得滤液200ml左右，药渣再加水300-400ml，煎熬30-40分钟，去渣得滤液100ml左右，两遍共煎熬药汤300ml左右。每日一剂分两次口服，每次空腹服150ml左右，三十天为一个疗程，服用至临床症状缓解，一般用二个疗程。
本发明主药山栀子主治：热病心烦、肝火目赤、头痛、湿热黄疳、淋证、血痢尿血、口舌生疮、疮疡肿毒、扭伤肿痛；使君子性温，有毒，味甘，归入脾、胃经。杀虫，消积，健脾。治蛔虫腹痛，小儿疳积，乳食停滞，腹胀，泻痢；白蔻温中涩肠，行气消食。用于虚泻。有健胃、驱风作用；苦楝子行气止痛，杀虫。主脘腹胁肋疼痛，疝痛，虫积腹痛，头癣，冻疮；莱菔子消食除胀，降气化痰。主治食积气滞，脘腹胀满，嗳气，下痢后重，咳嗽痰多，喘促胸满；四味相伍助君药，为方中臣药；佐以鸡屎藤具有滋阴壮阳、补气补血之功效，具有驱风镇咳、祛痰止泻、治疗感冒的作用；黄芪味甘，气微温，气薄而味浓，可升可降，阳中之阳也，无毒，专补气。入手太阴、足太阴、手少阴之经；草决明苦、甘、咸，性微寒，入肝、肾、大肠经，润肠通便，降脂明目，治疗便秘及高血脂，高血压。清肝明目，利水通便，有缓泻作用，降血压降血脂；紫苏发汗解表，理气宽中，解鱼蟹毒。用于风寒感冒，头痛，咳嗽，胸腹胀满，鱼蟹中毒；三棱破血，行气，消积，止痛。治癥瘕积聚，气血凝滞，心腹疼痛，胁下胀疼，经闭，产后瘀血腹痛，跌打损伤，疮肿坚硬；辛荑散风寒，通鼻窍。主治风寒头痛，鼻塞，鼻渊，鼻流浊涕；石斛味甘，性微寒。有生津养胃，滋阴清热，润肺益肾，明目强腰的功效；半枝莲清热解毒、活血化瘀，利水消肿，毒蛇咬伤，疔疮疖肿，还可以用于肺癌、以及肠胃道癌症；银柴胡清虚热，除疳热。用于阴虚发热，骨蒸劳热，小儿疳热；陈皮理气健脾，调中，燥湿，化痰。主治：脾胃气滞之脘、腹胀满或疼痛、消化不良。湿浊阻中之胸闷腹胀、纳呆便溏；白芥子为温里化痰药，其性走散，可开宣肺气，透达经络，尤善去寒痰及皮里膜外之痰。适于寒痰喘咳，胸胁满痛，痰注关节、肌肤所致关节疼痛、肢体不利等，共为方中使药。
本发明各原料还可按下表所列重量比例混合的实施例来实现。其加工工艺与实施例1相同。(单位：重量份)
下面结合我院进行的临床试验对本发明作进一步详细地描述：
诊断依据为：一、疳症。1、饮食异常，大便干稀不调，或脘腹膨胀等明显脾胃功能失调者；2、形体消瘦，体重低于正常平均值的15～40％，面色不华，毛发稀疏枯黄，严重者干枯赢瘦；3、兼有精神不振，或好发脾气，烦躁易怒，或喜揉眉擦眼，或吮指磨牙等症；4、有喂养不当或病后饮食失调及长期消瘦史；5、因蛔虫引起者，谓之“蛔疳”，大便镜检可查见蛔虫卵；6、贫血者，血红蛋白及红细胞减少；7、出现肢体浮肿，属于营养性水肿者，血清总蛋白量大多在45g/L以下，血清白蛋白约在20g/L以下。二、积滞。1、以不思饮食，食而不化，腹部胀满，大便溏泄或便秘为特征；2、可伴有烦躁不安，夜间哭闹或呕吐等症；3、有伤乳食史；4、大便化验检查可见不消化食物残渣及脂肪滴。
治疗方法：每日一剂分两次口服，每次空腹服150ml左右，三十天为一个疗程，服用至临床症状缓解，治疗二个疗程。
病例选择：2012年5月-2013年4月，共有200名患者使用。入选标准：被确诊为疳积的儿童，年龄1-4岁。200名患者随机均分为两大组，实验组及对照组，实验组使用实施例一所得中药组合物，每日一剂分两次口服，每次空腹服150ml左右。对照组使用西药治疗。两组均以30天为1个疗程，2个疗程后评定疗效。
主要考察症状、体征指标：(1)食欲恢复情况：食欲明显改善人数；(2)精神恢复情况；(3)体重增长情况：取治疗前各组患者体重平均数为基础数据，治疗周期结束后，再次取各组患者体重平均数与治疗前数据比较。
疗效情况判定标准：1、治愈：症状完全消失；2、有效：主要症状明显减轻，身体各项指标有所恢复；3、无效：与治疗前相比较，各方面均无明显进步。
表1：两组治疗前后临床症状体征评价情况比较
| 观察项目 | 时间 | 体重增加(％) | 食欲情况(人) |
| 实验组100人 | 治疗后 | 15 | 95 |
| 对照组100人 | 治疗后 | 8 | 75 |
注：上表中体重增加百分数与食欲情况数据均取平均数。
结果：两组治疗前后临床症状体征评价情况比较，治疗后两组患者2项主要疗效指标均有所改善，且实验组改善效果明显优于对照组。
表2：两组临床疗效比较【例(％)】
结果：两组临床疗效比较，对照组治愈率为35％，总有效率为88％；对照组治愈率为60％，总有效率为99％，两组临床疗效比较表明实验组疗效优于对照组。
Claims (1)
1.一种治疗小儿疳积的中药，其特征在于：由如下重量份的原料药制成，山栀子8-10份，使君子5-8份，鸡屎藤17-20份，黄芪10-14份，白蔻5-8份，苦楝子10-14份，草决明6-8份，莱菔子7-13份，紫苏7-10份，三棱5-8份，辛荑4-7份，石斛4-8份，半枝莲2-7份，银柴胡18-25份，陈皮4-5份，白芥子4-5份，将上述原料药混合后用水浸泡，煎熬后去渣得滤液。
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