CN104042667B - A kind of pharmaceutical composition for treating bronchial astehma and its application - Google Patents
A kind of pharmaceutical composition for treating bronchial astehma and its application Download PDFInfo
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- CN104042667B CN104042667B CN201410252941.4A CN201410252941A CN104042667B CN 104042667 B CN104042667 B CN 104042667B CN 201410252941 A CN201410252941 A CN 201410252941A CN 104042667 B CN104042667 B CN 104042667B
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Abstract
The present invention relates to a kind of pharmaceutical composition for treating bronchial astehma and its application, the pharmaceutical composition is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：18 26 parts of tylophora florlbunda, 28 50 parts of small sophora flower, 60 100 parts of Canton love-pea vine, 23 38 parts of dried human placenta, 10 20 parts of great burdock achene.The pharmaceutical composition of the present invention can substantially mitigate the clinical symptoms and sign of patient, the acute attack of Control of asthma, so as to improve the total effective rate of Treating Bronchial Asthma.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition for treating bronchial astehma
And its application.
Background technology
Bronchial astehma is one of respiratory system common disease, is a kind of respiratory tract chronic inflammation mediated by inflammatory factor
Property disease.The disease often induces because of factors such as climate change, infection, and patient often shows as coughing in acute attack stage, breathes heavily and suppress, be uncomfortable in chest
Deng the life quality of a series of symptoms, greatly influence patient.And the disease has the clinical characters of recurrent exerbation, patient is not only
Need to carry out drug therapy in acute stage, even more need to carry out hormone suction control in chronic remission stage, then add the suction of Western medicine to control
Treat and operating method is complex, do not meet Chinese population medication custom, this can undoubtedly cause Treatment Compliance to decline.Mirror
In this, the control of the clinical symptoms of Bronchial Asthmas is generally not ideal, so finding a kind of easy to use, safely, effectively
Therapeutic scheme, this seems particularly urgent for Bronchial Asthmas.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating bronchial astehma and application.The pharmaceutical composition
It is to improve and obtain on the basis of secret prescription handed down in the family from generation to generation, can substantially mitigates patient symptom, is a kind of specific drug for treating bronchial astehma.
The object of the present invention is achieved like this：
A kind of pharmaceutical composition for treating bronchial astehma, it by comprising following parts by weight traditional Chinese medicinal material raw materials prepare and
Into：Tylophora florlbunda 18-26 parts, small sophora flower 28-50 parts, Canton love-pea vine 60-100 parts, dried human placenta 23-38 parts, great burdock achene 10-20 parts.
Preferably, the pharmaceutical composition of bronchial astehma is treated as described above, and it is former by the Chinese medicine of following parts by weight
Material is prepared：Tylophora florlbunda 20-24 parts, small sophora flower 36-40 parts, Canton love-pea vine 72-80 parts, dried human placenta 28-32 parts, great burdock achene 13-
16 parts.
In the most preferred embodiment of the present invention, the as described above pharmaceutical composition for treating bronchial astehma by
The traditional Chinese medicinal material raw materials of following parts by weight are prepared：22 parts of tylophora florlbunda, 38 parts of small sophora flower, 75 parts of Canton love-pea vine, 30 parts of dried human placenta, ox
15 parts of burdock.
Found by experimental study, clinical condition of the pharmaceutical composition of the present invention for improvement Bronchial Asthmas
Shape and sign effect highly significant.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. said medicine group
Application of the compound in the medicine for preparing treatment bronchial astehma.
Preferably, when pharmacy is applied described in medicine be oral formulations.It is further preferred that described oral formulations bag
Include oral liquid, tablet, capsule, granule.
The preparation method of pharmaceutical composition of the present invention comprises the following steps：(1) the tylophora florlbunda 18-26 of recipe quantity is taken
Part, small sophora flower 28-50 parts, Canton love-pea vine 60-100 parts, dried human placenta 23-38 parts and great burdock achene 10-20 parts, impurity elimination is cleaned, is dried, powder
It is broken；(2) add water to cover powder 2cm above-mentioned graininess medicinal material again, soak 1-1.2h, pull out medicinal material put in multi-function extraction tank plus
The water secondary, 8-10 times of medicinal material of totalling is measured for the first time is boiled in decocting, decocts 2h, takes decocting liquid, filters, and adds up 6-8 times of medicinal material for the second time
The water of amount, 1h is decocted, take decocting liquid merging twice, filtration, relative density is 1.15g/mL concentrate when being concentrated into 90 DEG C；(3)
Concentrate is set to 0 into -5 DEG C of deepfreeze 24h, refrigeration liquid is added to 0.3% filter aid diatomite, filtration, filtrate is further concentrated to often
Milliliter crude drug amount containing 3g, sets to 0-5 DEG C of deepfreeze 24h, by refrigeration liquid filtration, obtains decoction.
The pharmaceutical composition of the present invention can substantially mitigate the clinical symptoms and sign of patient, the acute hair of Control of asthma
Make, so as to improve the total effective rate of Treating Bronchial Asthma, and drug safety, conveniently, few side effects, breaking-out time can be greatly reduced
Number and complication, strengthen the interdependence of patient medication.
Embodiment
It should be noted that the source for the traditional Chinese medicinal material raw materials that the present invention uses is as follows：Tylophora florlbunda selects Asclepiadaceae plant seven
The dry root of floor.Small sophora flower is from small sophora flower Desmodium caudatum (Thunb.) DC.'s of pulse family beggar-ticks plant
Dry root.Canton love-pea vine selects the whole herb with root of legume Guangdong jequirity.Dried human placenta selects the drying tire that healthy puerpera gives birth to
Disk.Great burdock achene is selected from feverfew burdock Arctium lappa L. dry mature fruit.
It is the specific embodiment of the present invention below, technical scheme is done and is further described, but it is of the invention
Protection domain be not limited to these embodiments.It is every to be included in this hair without departing substantially from the change of present inventive concept or equivalent substitute
Within bright protection domain.
The preparation of the traditional Chinese medicine oral liquid of embodiment 1
Tylophora florlbunda 220g, small sophora flower 380g, Canton love-pea vine 750g, dried human placenta 300g, great burdock achene 150g are weighed, cleans impurity elimination,
Dry, crush；Add water to cover powder 2cm above-mentioned graininess medicinal material again, soak 1-1.2h, pull medicinal material out and put multi-function extraction tank
In add water to cook secondary, add up the water of 10 times of medicinal material amount for the first time, decoct 2h, take decocting liquid, filter, add up 8 times of medicinal material second
The water of amount, 1h is decocted, take decocting liquid merging twice, filtration, relative density is 1.15g/mL concentrate when being concentrated into 90 DEG C；Will be dense
Contracting liquid sets to 0-5 DEG C of deepfreeze 24h, and refrigeration liquid is added to 0.3% filter aid diatomite, filtration, and filtrate is further concentrated to every milliliter
Crude drug amount containing 3g, -5 DEG C of deepfreeze 24h are set to 0, by refrigeration liquid filtration, obtain decoction.
The preparation of the traditional Chinese medicine oral liquid of embodiment 2
Tylophora florlbunda 200g, small sophora flower 500g, Canton love-pea vine 720g, dried human placenta 230g and great burdock achene 180g are weighed, cleans impurity elimination,
Dry, crush；Add water to cover powder 2cm above-mentioned graininess medicinal material again, soak 1-1.2h, pull medicinal material out and put multi-function extraction tank
In add water to cook secondary, add up the water of 8 times of medicinal material amount for the first time, decoct 2h, take decocting liquid, filter, add up 8 times of amounts of medicinal material second
Water, decoct 1h, take twice decocting liquid merging, filtration, when being concentrated into 90 DEG C relative density be 1.15g/mL concentrate；Will concentration
Liquid sets to 0-5 DEG C of deepfreeze 24h, and refrigeration liquid is added to 0.3% filter aid diatomite, filtration, and filtrate is further concentrated to every milliliter and contained
3g crude drug amounts, -5 DEG C of deepfreeze 24h are set to 0, by refrigeration liquid filtration, obtain decoction.
The preparation of the traditional Chinese medicine oral liquid of embodiment 3
Tylophora florlbunda 260g, small sophora flower 280g, Canton love-pea vine 800g, dried human placenta 350g and great burdock achene 100g are weighed, cleans impurity elimination,
Dry, crush；Add water to cover powder 2cm above-mentioned graininess medicinal material again, soak 1-1.2h, pull medicinal material out and put multi-function extraction tank
In add water to cook secondary, add up the water of 8 times of medicinal material amount for the first time, decoct 2h, take decocting liquid, filter, add up 6 times of amounts of medicinal material second
Water, decoct 1h, take twice decocting liquid merging, filtration, when being concentrated into 90 DEG C relative density be 1.15g/mL concentrate；Will concentration
Liquid sets to 0-5 DEG C of deepfreeze 24h, and refrigeration liquid is added to 0.3% filter aid diatomite, filtration, and filtrate is further concentrated to every milliliter and contained
3g crude drug amounts, -5 DEG C of deepfreeze 24h are set to 0, by refrigeration liquid filtration, obtain decoction.
The preparation of the traditional Chinese medicine oral liquid of embodiment 4
Tylophora florlbunda 180g, small sophora flower 430g, Canton love-pea vine 1000g, dried human placenta 350g and great burdock achene 120g are weighed, cleans and goes
It is miscellaneous, dry, crush；Add water to cover powder 2cm above-mentioned graininess medicinal material again, soak 1-1.2h, pull medicinal material out and put multi-functional carry
Take and add water to cook secondary in filling, add up the water of 8 times of medicinal material amount for the first time, decoct 2h, take decocting liquid, filter, add up medicinal material 6 second
Times amount water, decoct 1h, take twice decocting liquid merging, filtration, when being concentrated into 90 DEG C relative density be 1.15g/mL concentrate；Will
Concentrate sets to 0-5 DEG C of deepfreeze 24h, and refrigeration liquid is added to 0.3% filter aid diatomite, filtration, and filtrate is further concentrated to every milli
Crude drug amount containing 3g is risen, sets to 0-5 DEG C of deepfreeze 24h, by refrigeration liquid filtration, obtains decoction.
The traditional Chinese medicine oral liquid of embodiment 5 was studied the effect of Bronchial Asthmas
57 Bronchial Asthmas, wherein male 38, women 19, age are 36-77 year, average age 46.5
± 1.9 years old；Course of disease 2-30, average course of disease 8.6 ± 5.3 years.All patients are divided into test group (28) and control group at random
(29).Notable difference is not present in sex, age, the state of an illness, the course of disease etc. in two groups of patients, has comparativity.
Traditional Chinese medicine oral liquid prepared by the oral method of the embodiment of the present invention 1 of test group patient, daily in the morning, afternoon and evening it is each once, every time
30mL；2 weeks are a course for the treatment of, take 2 courses for the treatment of altogether.Control group patient aerosol suction people beclomethasone dipropionate (50 μ g/ are pressed), 1
Press/time, daily sooner or later each 2 times, continuous use one month.
Evaluation criteria of the situation as clinical efficacy is improved according to the clinical symptoms of two groups of patients and sign, be divided into altogether as
Lower three ranks：
It is 1. effective：Panting occasionally has breaking-out, mild degree, does not influence rest or activity；Cough and be interrupted cough daytime, degree is slight；
Wheezing sound is occasionally heard or occurred after the deep fast breathing of cough.
It is 2. effective：Pant and cough and taken a turn for the better, but not yet reach effective degree, exist and be dispersed in wheezing sound.
It is 3. invalid：After treatment, pant, cough and wheezing sound does not improve, or even degradating trend occur.
Two groups of Clinical efficacy comparison specific test results are shown in Table 1 after treatment.
The Clinical efficacy comparison of the test group of table 1 and control group
Claims (5)
1. a kind of pharmaceutical composition for treating bronchial astehma, it is characterised in that described pharmaceutical composition is by following parts by weight
Traditional Chinese medicinal material raw materials are prepared：Tylophora florlbunda 20-24 parts, small sophora flower 36-40 parts, Canton love-pea vine 72-80 parts, dried human placenta 28-32 parts, ox
Burdock 13-16 parts.
2. the pharmaceutical composition for the treatment of bronchial astehma according to claim 1, it is characterised in that described drug regimen
Thing is prepared by the traditional Chinese medicinal material raw materials of following parts by weight：22 parts of tylophora florlbunda, 38 parts of small sophora flower, 75 parts of Canton love-pea vine, dried human placenta 30
Part, 15 parts of great burdock achene.
3. application of the pharmaceutical composition in the medicine for preparing treatment bronchial astehma described in claim 1 or 2.
4. application according to claim 3, it is characterised in that：Described medicine is oral formulations.
5. application according to claim 4, it is characterised in that：Described oral formulations include oral liquid, tablet, capsule, particle
Agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410252941.4A CN104042667B (en) | 2014-06-09 | 2014-06-09 | A kind of pharmaceutical composition for treating bronchial astehma and its application |
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| CN201410252941.4A CN104042667B (en) | 2014-06-09 | 2014-06-09 | A kind of pharmaceutical composition for treating bronchial astehma and its application |
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| CN104042667A CN104042667A (en) | 2014-09-17 |
| CN104042667B true CN104042667B (en) | 2017-12-26 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908565A (en) * | 2012-10-24 | 2013-02-06 | 尹甲仑 | Chinese herbal medicine decoction for curing bronchial asthma and preparation method of Chinese herbal medicine decoction |
| CN103784812A (en) * | 2014-01-26 | 2014-05-14 | 李艳 | Traditional Chinese medicine for treating asthma |
-
2014
- 2014-06-09 CN CN201410252941.4A patent/CN104042667B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908565A (en) * | 2012-10-24 | 2013-02-06 | 尹甲仑 | Chinese herbal medicine decoction for curing bronchial asthma and preparation method of Chinese herbal medicine decoction |
| CN103784812A (en) * | 2014-01-26 | 2014-05-14 | 李艳 | Traditional Chinese medicine for treating asthma |
Non-Patent Citations (2)
| Title |
|---|
| 支气管哮喘的中医治疗;储军;《现代中西医结合杂志》;20070630;第16卷(第16期);第2185-2186页 * |
| 支气管哮喘的中医病因病机与辨证论治研究;宋立群等;《中医药学报》;20091231;第37卷(第4期);第9-11页 * |
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Inventor after: Pan Jianliang Inventor after: Liang Tingting Inventor after: Hu Dezhong Inventor after: Hou Jianhua Inventor after: Sun Xianchen Inventor after: Han Xuelin Inventor after: Zhou Baojian Inventor before: Zhuang Xiaokan |
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Effective date of registration: 20171129 Address after: 234000 Anhui province Suzhou City Yongqiao district near the River Road No. 229 Applicant after: Anhui Huateng agricultural science and Technology Co. Ltd. Address before: A view of the sea road 266000 in Shandong Province, Qingdao City, No. 29 room 121 Applicant before: Qingdao Shen Da new and high technology development corporation, Ltd. |
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Effective date of registration: 20211122 Address after: 264200 No. 220, Keji Road, torch high tech Industrial Development Zone, Weihai City, Shandong Province Patentee after: Weihai high tech Park Operation Management Co.,Ltd. Address before: 234000 No. 229 Bianhe East Road, Tuoqiao District, Suzhou City, Anhui Province Patentee before: ANHUI HUATENG AGRICULTURAL TECHNOLOGY Co.,Ltd. |
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