CN106215097A - A kind of Chinese medicine preparation treating chronic cardiopulmonary disease and preparation method thereof - Google Patents
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine preparation treating chronic cardiopulmonary disease and preparation method thereof, Chinese medicine preparation includes following raw medicinal material: Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Polygoni Cuspidati, Rhizoma Polygonati Odorati, Radix Glehniae, Fructus Psoraleae, Radix Aconiti Lateralis Preparata, the Radix Astragali, Rhizoma Curcumae Longae, Radix Adenophorae, Herba Epimedii and Radix Glycyrrhizae.Wherein tablet pulverizes by Radix Salviae Miltiorrhizae, sieves, fine powder, other composition decocts, filters, concentrates, extractum, spray drying, clear paste powder, finally both mix, pelletize, be dried, granulate, tabletting, coating, subpackage, packaging, finished product are made；Capsule is pulverized by Radix Salviae Miltiorrhizae, is sieved, fine powder, and other composition decocts, filters, concentrates, extractum, spray drying, clear paste powder, last the two mix, pelletize, be dried, always mix, filling, subpackage, packaging, finished product are made.The Chinese medicine preparation that the present invention provides, has no adverse reaction, and safety is high, and crude drug is cheap, is easy to get, and long-term taking economic pressures are little.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation treating chronic cardiopulmonary disease and system thereof
Preparation Method.
Background technology
Pulmonary heart disease, also referred to as pulmonary heart disease (corpulmonale), can be divided into acute pulmonary heart disease and chronic
Pulmonary heart disease.Pulmonary heart disease is primarily referred to as the extensive thromboembolism of pulmonary trunk or its branch, and pulmonary vascular resistance increases, and exceedes the right heart and bears
Lotus, cause pulmonary hypertension, right ventricle increase with or without one group of disease of congestive heart failure.Bulk pulmonary artery bolt
Cezanne can cause sudden death, medium big pulmonary infarction can cause pulmonary infarction, and little pulmonary infarction can be without obvious clinical symptoms.Acute lung source
Property heart disease more rare, the pulmonary heart disease of clinical indication is mainly chronic pulmonary heart disease.
Chronic pulmonary heart disease (chronic cor pulmonale) is by lung tissue, pulmonary artery or thorax
Chronic disease causes lung tissue structure and dysfunction, and producing pulmonary vascular resistance increases, and pulmonary artery pressure increases, and makes the right heart expand
, loose, companion or do not accompany the heart disease of right heart failure.It can betide old people, but majority is from middle age delay development
Come.Senile Cor Pulmonale Treated be mostly from chronic obstructive pulmonary disease (chronic obstructive pulmonary disease,
COPD) develop.Its sickness rate is the highest, especially in smoking population, and in the trend increased year by year.
Primary disease slower development, clinically except original lung, breast disease various sings and symptomses in addition to, mainly progressively occur
The sign of lung, cardiac insufficiency and other impaired organ, often performance is that acute attack stage was alternately present with the catabasis, lung,
Cardiac insufficiency deteriorates the most further, and the more, lung, impaired heart function are the heaviest for acute episode frequency.Below by its function
The compensatory phase is illustrated by respectively with Decompensated stage.
1. lung, cardiac functional compensatory period: this phase cardiac functional compensation is the best, pulmonary function is in the part compensatory stage, mainly
Be the performance of chronic obstructive pulmonary disease, be i.e. chronic cough, expectoration, pant, can feel after activity cardiopalmus, breathe hard, dyspnea and labor
Dynamic endurance declines, and has the hypoxic conditions such as cyanosis in various degree.Obvious emphysema sign seen from health check-up, such as barrel chest, lung percussion
Hyperresonant note, auscultation respiratory murmur generally weakens, and often can hear sound dry, wet.Though right ventricle expands, but the often heart because emphysema exist
Voiced sound is difficult to kowtow out, and heart sound is remote.P2 hyperfunction (this sign also can be inconspicuous because emphysema exist), carries
It is shown with pulmonary hypertension to exist.Under xiphoid-process, visible paradoxical expansion is beaten, and TA can hear paradoxical expansion noise, auscultation
Under sword, heart sound is better than apex, and many promptings have right ventricle plump and expand.Some cases makes intrathoracic pressure liter because of severe emphysema
Height, hinders Vena cava return, may occur in which that jugular vein fills；Declining because of diaphram again, margo interior hepatis can touch under rib, exactly like the right heart
Insufficient sign, but now venous pressure is without significantly raised, the most non-blood stasis of liver, and anteroposterior diameter does not increase, and without tenderness, can
Give discriminating.
2. lung, cardiac functional decompensatory period: current period clinic mainly shows with respiratory failure and heart failure, and most of patients is to exhale
It is main for inhaling exhaustion, and heart failure then occurs；Also there is the small number of patients can be without heart failure or based on heart failure.(1) breathe
Exhaustion: acute respiratory infection is modal inducement.Its clinical characters sees a respiratory failure piece.(2) heart failure: with the right heart
Exhaustion is main, and small number of patients may occur in which acute lung edema or whole heart failure, it is possible to arrhythmia occurs.
Chronic cardiopulmonary disease is commonly encountered diseases, frequently-occurring disease in China, and average prevalence is 0.48%, and chronic cardiopulmonary disease is in the course of disease
Often repeatedly go to a doctor because of various acute complicationses and be in hospital.The common heart failure of chronic pulmonary heart disease, pulmonary infection, exhale
Inhale exhaustion, pulmonary encephalopathy and arrhythmia, shock, disseminated inravascular coagulation, upper gastrointestinal hemorrhage, multiple organ dysfunction etc.
Complication.Owing to treatment is dissatisfied, chronic cardiopulmonary disease case fatality rate is the highest, and average about 30%.
Summary of the invention
It is an object of the invention to overcome the deficiency of background technology, it is provided that a kind of Chinese medicine preparation treating chronic cardiopulmonary disease and
Preparation method, preparation method is simple, it is provided that Chinese medicine preparation good stability, good effect, have no side effect.
The present invention adopts the following technical scheme that realization:
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease, is made up of the following raw material counted by weight: Radix Salviae Miltiorrhizae 14.4～36 parts,
Flos Carthami 7.2～21.6 parts, Rhizoma Polygoni Cuspidati 14.4～28.8 parts, Rhizoma Polygonati Odorati 14.4～36 parts, Radix Glehniae 14.4～28.8 parts, Fructus Psoraleae 7.2
～36 parts, Radix Aconiti Lateralis Preparata 4.32～11.52 parts, the Radix Astragali 14.4～28.8 parts, Rhizoma Curcumae Longae 14.4～36 parts, Radix Adenophorae 7.2～43.2 parts,
Herba Epimedii 14.4～57.6 parts and Radix Glycyrrhizae 1.44～12.96 parts.
Preferably, the Chinese medicine preparation of described treatment chronic cardiopulmonary disease, it is made up of the following raw material counted by weight: Radix Salviae Miltiorrhizae
36 parts, 14.4 parts of Flos Carthami, Rhizoma Polygoni Cuspidati 21.6 parts, Rhizoma Polygonati Odorati 36 parts, Radix Glehniae 21.6 parts, Fructus Psoraleae 21.6 parts, Radix Aconiti Lateralis Preparata 7.2 parts, yellow
Stilbene 21.6 parts, 21.6 parts of Rhizoma Curcumae Longae, Radix Adenophorae 21.6 parts, Herba Epimedii 36 parts and 7.2 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease, the dosage form of described Chinese medicine preparation is tablet, its
Preparation method comprises the following steps:
1. Radix Salviae Miltiorrhizae powder is broken into fine powder, standby；
2. remaining medical material in described Chinese medicine preparation is mixed in proportion, boiling secondary, merges decoction liquor, filter, will
Filtrate is condensed into the clear paste that relative density is 14 ° of B é, is spray-dried by clear paste；
3. putting in trough type mixing machine by Radix Salviae Miltiorrhizae fine powder and clear paste powder, mix homogeneously, is 80%～the ethanol solution system of 90% by concentration
Grain, is dried, and takes out, cools, and by dry granule granulate, the granule crossed by granulate is put in three-dimensional mixer, adds grain amount 0.5%
Magnesium stearate, mixing, take out, tabletting, coating, make.
The preparation method of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease, the dosage form of described Chinese medicine preparation is capsule,
It is characterized in that with method for preparing tablet thereof difference be step 3. for Radix Salviae Miltiorrhizae fine powder and clear paste powder are put in trough type mixing machine, add dense
Degree is the ethanol solution of 75%～80%, makes soft material after continuing stirring 8～10 minutes, standby；Repeat above step 1 time；Pelletize,
Forced air drying under the conditions of 75 DEG C ± 5 DEG C；Start every about 2 hours to fall dish once to being dried, when pellet moisture is less than 7%, whole
Grain, always mixes, and capsule is filled, and gets product.
Preferably, described step 1. in fine powder all by 80 mesh sieves, and pass through 100 mesh sieves more than 95%.
Preferably, in described step 2. middle boiling secondary, first time amount of water is 9 times of medical material amount, decocts 4 hours,
Amount of water is 8 times of medical material amount for the second time, decocts 3 hours.
Preferably, during described step 2. middle spray drying, spraying machine inlet temperature is 190 DEG C～220 DEG C, and outlet temperature is
90 DEG C～110 DEG C.
Preferably, step 3. middle granulation, granulate 14 mesh sieves.
Preferably, when the dosage form of described Chinese medicine preparation is tablet, step 3. in ethanol solution consumption be Radix Salviae Miltiorrhizae fine powder with
The 15%～30% of clear paste grain weight amount.
Preferably, when the dosage form of described Chinese medicine preparation is capsule, described step 3. middle ethanol solution consumption is Radix Salviae Miltiorrhizae
Fine powder and the 10%～20% of clear paste grain weight amount.
Beneficial effect: the Chinese medicine preparation that the present invention provides, it is possible to coordinate doctor trained in Western medicine conventional method therapeutic alliance chronic cardiopulmonary disease,
Can significantly improve the therapeutic effect of conventional method, have no side effect and untoward reaction, safety is high, and crude drug is cheap, be easy to get,
Long-term taking economic pressures are little, have good application and popularization value.
Accompanying drawing explanation
Fig. 1 is process chart prepared by Tablets；
Fig. 2 is process chart prepared by capsule of the present invention.
Detailed description of the invention
The present invention provides a kind of pure Chinese medicinal preparation treating chronic cardiopulmonary disease, and described Chinese medicine preparation includes following crude drug
Material: Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Polygoni Cuspidati, Rhizoma Polygonati Odorati, Radix Glehniae, Fructus Psoraleae, Radix Aconiti Lateralis Preparata, the Radix Astragali, Rhizoma Curcumae Longae, Radix Adenophorae, Herba Epimedii and Radix Glycyrrhizae.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Radix Salviae Miltiorrhizae: [source] is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.[property
Can feature] this product hardship can let out scattered, and being slightly cold can be clear, enter the heart, Liver Channel.Both blood circulation promoting and blood stasis dispelling and inducing menstruation to relieve menalgia, clear away heart-fire again removing heat from blood and relieving restlessness,
Eliminating carbuncle, cures mainly blood stasis, heat in blood, heat disturb all cards of the mind, double controls pyretic toxicity sore, carbuncle and painful swelling.Gu Yun " Radix Salviae Miltiorrhizae dissipates simply, the same SIWU TANG of merit ",
And the product that actually promoting tissue regeneration by removing blood stasis, removing heat from blood clear away heart-fire.[effect] blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.
Flos Carthami: [source] is the dry flower of feverfew Flos Carthami.[meridian distribution of property and flavor] is pungent, temperature.GUIXIN, Liver Channel.[performance is special
Point] the pungent scattered temperature of this product lead to, enter the heart, Liver Channel.Can invigorate blood circulation and unobstructed passages through which vital energy circulates, dissipating blood stasis and the pain relieving that disappears, kind control all cards of congestion, hold concurrently cold person
The most suitable.[effect] promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
Rhizoma Polygoni Cuspidati: [source] is dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.[meridian distribution of property and flavor] is bitter, is slightly cold.Return liver, gallbladder, lung
Warp.The hardship energy drop-down of [performance characteristics] this product, being slightly cold can be clear, and master enters liver, gallbladder meridian.Main analgesic therapy of invigorating blood circulation, expelling wind and removing dampness, heat clearing away solution
Poison, preventing phlegm from forming and stopping coughing, and double relieving constipation by purgation.Both controlled blood stasis, damp and hot, pyretic toxicity, lung-heat and the various disease conditions caused by intestinal accumulation of heat, controlled again
Scald and venom etc..[effect] dampness removing jaundice eliminating, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, preventing phlegm from forming and stopping coughing, relieving constipation by purgation.
Rhizoma Polygonati Odorati: the dry rhizome of [source] liliaceous plant Rhizoma Polygonati Odorati.[meridian distribution of property and flavor] is sweet, flat.Attach to the lung and stomach meridians.[performance is special
Point] this product Gan Run and mend, flat and few partially.Enter lung meridian, can lung-yin nourishing and nourishing the lung to arrest cough；Enter stomach warp, can nourishing stomach-YIN and promoting the production of body fluid to quench thirst.
Ancient name is luxuriant, does not grow greasy love heresy, use same with diaphoretic medicine, can receive the merit of nourishing YIN and relieving the exterior syndrome.[effect] nourishing YIN and moistening the lung, nourishing the stomach of promoting the production of body fluid.
Radix Glehniae: [source] is the dry root of samphire glehnia littoralis.[meridian distribution of property and flavor] is sweet, be slightly cold.Attach to the lung and stomach meridians.
[performance characteristics] this product sweet in the mouth can be mended, and is slightly cold refrigerant, enters lung, stomach warp, for the product of cool benefit.Kind nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, control lung
Deficiency of stomach-YIN has hot all cards.[effect] nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.
Fructus Psoraleae: [source] is the dry mature fruit of legumes psoraleae.[meridian distribution of property and flavor] is pungent, bitter, temperature.Return kidney,
Spleen channel.[performance characteristics] this product toil warm-dryness syndrome, temperature compensation is puckery to be received, and enters kidney, spleen channel.Both kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, helping inspiration to relieve asthma,
The most warming spleen and stopping diarrha.Name Fructus Psoraleae person, is its homophonic doing of rectification of name.[effect] kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, receive
Gas is relievingd asthma.
Radix Aconiti Lateralis Preparata: Radix Aconiti Lateralis Preparata [source] is the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx..[meridian distribution of property and flavor] is pungent, the hottest.Have
Poison.GUIXIN, kidney, spleen channel.The hot pure sun of [performance characteristics] this product, high strong poisonous, enter the heart, kidney, spleen channel, the efficacy of a drug is the strongest.On help the heart
Spleen reinforcing positive, middle invigorating kidney-YANG positive, lower, for mending supporing yang, the key medicine of recuperating depleted YANG and rescuing the patient from collapse of fire, controls YANG-depletion and all cards of yang deficiency is often used.The most hot walk
Dissipate, for scattered YIN-cold, except rheumatism, the violent medicine of the pain that relieves the pain, control all pains of cold-damp and often throw.[effect] recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, and cold expelling is only
Bitterly.The Radix Aconiti Lateralis Preparata of this formula is to be used as medicine with Radix Aconiti Lateralis Preparata.
The Radix Astragali: [source] is the dry root of leguminous plant Radix Astagali or Radix Astragali.[meridian distribution of property and flavor] is sweet, tepor.Return
Spleen, lung meridian.The sweet temperature rise of [performance characteristics] this product is mended, and enters spleen, lung meridian, main with righting gas, holds concurrently and can remove pathogenic water.Both invigorating middle warmer gas, liter it be apt to
Lift clear sun, be apt to again tonifying the lung gas, benefit defends consolidating superficial resistance, moreover it is possible to torr sore, inducing diuresis to remove edema.Additionally, by QI invigorating again can hemopoietic, take the photograph blood, life
Tianjin, row are stagnant, control blood deficiency and yellow complexion, the metrorrhagia of QI failing to control blood is had blood in stool, the quenching one's thirst of gas Tianjin two wound, the arthralgia pain of blood stagnancy due to deficiency of QI are numb and half body
Unsuccessful etc..[effect] tonifying Qi and lifting yang, benefit defends consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema.
Rhizoma Curcumae Longae: [source] is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae.[meridian distribution of property and flavor] acrid, bitter, warm.Return liver, kidney channel.[property
Can feature] to let out temperature logical for the pungent scattered hardship of this product, enters liver, kidney channel.Kind blood-activating and qi-promoting, inducing menstruation to relieve menalgia, dispersing wind and cold damp of holding concurrently, and horizontal walk limb
Arm.Controlling all pains of stagnation of QI and blood, the cold person that holds concurrently is the most suitable；Dispelling the wind and dampness pathogens shoulder brachialgia, with cold coagulation, resistance network person is optimal.[effect] removing blood stasis circulation of qi promoting, logical
Meridian and relieving pain.
Radix Adenophorae: [source] is the fresh or dry root of Campanulaceae adenophora tetraphylla or Radix Adenophorae (Radix Glehniae).[meridian distribution of property and flavor] is sweet, micro-
Cold.Attach to the lung and stomach meridians.[performance characteristics] this product sweet in the mouth can be mended, and is slightly cold refrigerant, enters lung, stomach warp, for the product of cool benefit.Main foster with lung heat clearing
Cloudy, reinforcing stomach reg fluid, holds concurrently with QI invigorating, eliminates the phlegm, and being apt to control lung-stomach yin deficiency has hot all cards, and the deficiency of vital energy of holding concurrently or folder expectorant person are the most suitable.[effect] lung heat clearing
Yin nourishing, eliminates the phlegm, QI invigorating.
Herba Epimedii: [source] is the dry of Berberidaceae plant Herba Epimedii, Epimedium sagittatum, E. Pubescens or Herba Epimedii
Dry leaf.[meridian distribution of property and flavor] is pungent, sweet, warm.Return liver, kidney channel.The pungent sweet warm-dryness syndrome of [performance characteristics] this product, enters liver, kidney channel, both kidney-replenishing and
Bone and muscle strengthening, again wind-damp dispelling and exempt from arthralgia pain.Its power is stronger and efficacious, therefore has another name called Herba Epimedii.[effect] kidney-replenishing, bone and muscle strengthening, dispel
Rheumatism.
Radix Glycyrrhizae: [source] is the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..[meridian distribution of property and flavor]
Sweet, flat.Return spleen, stomach, lung, heart channel.[performance characteristics] this product sweet in the mouth flat, main enter spleen, lung meridian, double enter stomach, heart channel.Both QI invigorating was mended
In, relieving spasm to stop pain, the mitigation property of medicine, go back expelling phlegm for arresting cough, removing toxic substances again.Processed with honey is flat and temperature partially, and QI invigorating emergency power is strong；Raw with flat and inclined
Cool, can eliminating fire and detoxication.[effect] QI invigorating invigorating middle warmer, expelling phlegm for arresting cough, removing toxic substances, relieving spasm to stop pain, relaxes the property of medicine.
Embodiment 1
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease, is made up of following raw material: Radix Salviae Miltiorrhizae 36kg, Flos Carthami 14.4kg, Rhizoma Polygoni Cuspidati
21.6kg, Rhizoma Polygonati Odorati 36kg, Radix Glehniae 21.6kg, Fructus Psoraleae 21.6kg, Radix Aconiti Lateralis Preparata 7.2kg, Radix Astragali 21.6kg, Rhizoma Curcumae Longae 21.6kg,
Radix Adenophorae 21.6kg, Herba Epimedii 36kg and Radix Glycyrrhizae 7.2kg.
The preparation method of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease, the dosage form of described Chinese medicine preparation is tablet, its
Preparation method comprises the following steps:
1. the medical material Radix Salviae Miltiorrhizae powder in described Chinese medicine preparation is broken into fine powder, all by 80 mesh sieves, and by 100 mesh sieves
More than 95%, standby；
2. being mixed in proportion by remaining medical material in described Chinese medicine preparation, boiling secondary, amount of water is medical material for the first time
9 times of amount, decoct 4 hours, and amount of water is 8 times of medical material amount for the second time, decocts 3 hours, and merging decoction liquor, filtration, by filtrate
Being condensed into the clear paste that relative density is 14 ° of B é, be spray-dried by clear paste, spraying machine inlet temperature is 190 DEG C～220 DEG C, outlet
Temperature is 90 DEG C～110 DEG C；
3. Radix Salviae Miltiorrhizae fine powder and clear paste powder are put in trough type mixing machine, mix homogeneously, with the ethanol solution that concentration is 80%～90% with
14 mesh sieves are pelletized, and ethanol solution consumption is the 15%～30% of Radix Salviae Miltiorrhizae fine powder and clear paste grain weight amount, and 60 DEG C are dried, and take out, cool, will
Dry granule is put in three-dimensional mixer with 14 mesh sieve granulate, the granule crossed by granulate, adds the magnesium stearate of grain amount 0.5%, mixing
30 minutes, taking out, tabletting makes every tablet weight 0.31 gram, coating, makes.
Fig. 1 is its preparation technology flow chart, wherein pulverize, sieve, fine powder, spray drying, clear paste powder, mix, pelletize, dry
Dry, granulate, tabletting, coating, layered water flood well step complete in 300,000 grades of clean areas.
Embodiment 2
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease, is made up of following raw material: Radix Salviae Miltiorrhizae 36kg, Flos Carthami 7.2kg, Rhizoma Polygoni Cuspidati
28.8kg, Rhizoma Polygonati Odorati 21.6kg, Radix Glehniae 14.4kg, Fructus Psoraleae 14.4kg, Radix Aconiti Lateralis Preparata 11.52kg, Radix Astragali 14.4kg, Rhizoma Curcumae Longae
25.92kg, Radix Adenophorae 14.4kg, Herba Epimedii 43.2kg and Radix Glycyrrhizae 12.96kg.
The dosage form of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease is tablet, and its preparation method is with embodiment 1, and Fig. 1 is it
Preparation technology flow chart, wherein pulverize, sieve, fine powder, spray drying, clear paste powder, mix, pelletize, be dried, granulate, tabletting, bag
Clothing, layered water flood well step complete in 300,000 grades of clean areas.
Embodiment 3
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease, is made up of following raw material: Radix Salviae Miltiorrhizae 14.4kg, Flos Carthami 17.28kg, Rhizoma Polygoni Cuspidati
14.4kg, Rhizoma Polygonati Odorati 36kg, Radix Glehniae 28.8kg, Fructus Psoraleae 7.2kg, Radix Aconiti Lateralis Preparata 10.08kg, Radix Astragali 17.28kg, Rhizoma Curcumae Longae 36kg,
Radix Adenophorae 7.2kg, Herba Epimedii 57.6kg and Radix Glycyrrhizae 1.44kg.
The preparation method of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease, the dosage form of described Chinese medicine preparation is capsule,
Its preparation method comprises the following steps:
1. the medical material Radix Salviae Miltiorrhizae powder in described Chinese medicine preparation is broken into fine powder, all by 80 mesh sieves, and by 100 mesh sieves
More than 95%, standby；
2. remaining medical material in described Chinese medicine preparation is mixed in proportion, boiling secondary, 4 hours for the first time, for the second time 3
Hour, merge decoction liquor, filter, filtrate is condensed into the clear paste that relative density is 14 ° of B é, clear paste is spray-dried, spraying machine
Inlet temperature is 190 DEG C～220 DEG C, and outlet temperature is 90 DEG C～110 DEG C；
3. Radix Salviae Miltiorrhizae fine powder and clear paste powder are put in trough type mixing machine, add the ethanol solution that concentration is 75%～80%, ethanol solution
Consumption is the 10%～20% of Radix Salviae Miltiorrhizae fine powder and clear paste grain weight amount, makes soft material after continuing stirring 8～10 minutes, standby；Repeat with
Upper step 1 time；Pelletize with 14 mesh sieves, forced air drying under the conditions of 75 DEG C ± 5 DEG C；Every about 2 hours dishes one are started to being dried
Secondary, when pellet moisture is less than 7%, with 14 mesh sieve granulate, always mix, capsule is filled and made every weight is 0.30g, gets product.
Fig. 2 is its preparation technology flow chart, wherein pulverize, sieve, fine powder, spray drying, clear paste powder, mix, pelletize, dry
Dry, total mixed, fill, layered water flood well step completes in 300,000 grades of clean areas.
Embodiment 4
A kind of Chinese medicine preparation treating chronic cardiopulmonary disease, is made up of following raw material: Radix Salviae Miltiorrhizae 21.6kg, Flos Carthami 21.6kg, Rhizoma Polygoni Cuspidati
21.6kg, Rhizoma Polygonati Odorati 14.4kg, Radix Glehniae 21.6kg, Fructus Psoraleae 36kg, Radix Aconiti Lateralis Preparata 4.32kg, Radix Astragali 28.8kg, Rhizoma Curcumae Longae 14.4kg,
Radix Adenophorae 43.2kg, Herba Epimedii 14.4kg and Radix Glycyrrhizae 4.32kg.
The dosage form of the Chinese medicine preparation of described treatment chronic cardiopulmonary disease is capsule, and its preparation method with embodiment 3, Fig. 2 is
Its preparation technology flow chart, wherein pulverize, sieve, fine powder, spray drying, clear paste powder, mix, pelletize, be dried, total mixed, fill,
Layered water flood well step completes in 300,000 grades of clean areas.
Performance test
1, embodiment 1～4 product having been carried out stability test, its result is as shown in table 1～4:
2, toxicity test:
Acute toxicity testing: 50 healthy mices, male and female half and half, body weight is more or less the same, and carries out acute toxicity test.Mice is random
It is divided into 2 groups, i.e. matched group and administration group.Before experiment, fasting 12 hours, is dissolved in the water the Chinese medicine preparation of the present invention, gavage,
Given low is respectively 2.5 g kg-1·d-1、5.0 g·kg-1·d-1、7.5g·kg-1·d-1；Matched group is with 7.5mL
kg-1·d-1Normal saline gavage, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result
Showing: compare with matched group, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet,
Drinking-water, body weight increase the most normal.Therefore the Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: 60 healthy mices, male and female half and half, is divided into 3 groups, and the present invention implements the Chinese medicine system of preparation
Agent, respectively by 2.5 g kg-1·d-1、5.0 g·kg-1·d-1、7.5g·kg-1·d-1Continuously medicine feed 4 months and drug withdrawal 4 weeks
After, result shows: the Chinese medicine preparation of the present invention is to the hair of mice, behavior, defecation, body weight, organ weights, hemogram, Liver and kidney
The indexs such as function, blood glucose, blood fat have no and significantly affect, and internal organs naked eyes do not find difference change and histological indications table
Bright, after medication 4 months and drug withdrawal 4 weeks, mice internal organs are all without substantially changing.After illustrating that this Chinese medicine preparation is to mice Long-term taking medicine
Toxicity is little, and after drug withdrawal, also the most significantly difference is reacted, application safety.
3, clinical data:
Case selection: 75 example patients, is randomly divided into treatment group 1, treatment group 2, matched group, often organizes 25 people, three groups of patients sex,
The aspects such as age, the course of disease and clinical manifestation, without obvious significant difference, have comparability.
Matched group: use western medicine routine treatment, including: oxygen uptake, diastole bronchus medicine, infection, preventing phlegm from forming and stopping coughing, flat
Breathe heavily, diuresis, the randomized controlled treatment such as correction electrolyte disturbance and acid-base balance, within 4 weeks, be a course for the treatment of.
Treatment group 1: take on the basis of matched group the present invention implement tablet or capsule, each 5 (or grains), often
They 3 times, 4 weeks be a course for the treatment of.
Treatment group 2: withdraw other medicines, takes tablet or capsule, each 5 (or grains), every day 3 that the present invention implements
Secondary, within 4 weeks, it is a course for the treatment of.
Therapeutic outcome: after treatment group 1, treatment group 2, matched group treat 1 course for the treatment of respectively, statistical result is shown in Table 5.
Table 5 matched group and therapeutic component do not treat Clinical efficacy comparison after 1 course for the treatment of
From table 5 it can be seen that treatment group 1 uses the Chinese medicine preparation of the present invention to coordinate routine of western medicine method treatment pulmonary heart disease (chronic
Pulmonary heart disease), relative to simple use doctor trained in Western medicine routine integrated approach according to group, curative effect has the most progressive.Treatment
Group 2 is only taken the Chinese medicine preparation treatment pulmonary heart disease of the present invention and is had certain effect, and is better than the routine of western medicine method treatment lung heart
Sick (chronic pulmonary heart disease).
Claims (10)
1. the Chinese medicine preparation treating chronic cardiopulmonary disease, it is characterised in that be made up of the following raw material counted by weight: red
Join 14.4～36 parts, Flos Carthami 7.2～21.6 parts, Rhizoma Polygoni Cuspidati 14.4～28.8 parts, Rhizoma Polygonati Odorati 14.4～36 parts, Radix Glehniae 14.4～28.8
Part, Fructus Psoraleae 7.2～36 parts, Radix Aconiti Lateralis Preparata 4.32～11.52 parts, the Radix Astragali 14.4～28.8 parts, Rhizoma Curcumae Longae 14.4～36 parts, Radix Adenophorae
7.2～43.2 parts, Herba Epimedii 14.4～57.6 parts and Radix Glycyrrhizae 1.44～12.96 parts.
The Chinese medicine preparation for the treatment of chronic cardiopulmonary disease the most according to claim 1, it is characterised in that by following by weight
The raw material composition of meter: Radix Salviae Miltiorrhizae 36 parts, 14.4 parts of Flos Carthami, Rhizoma Polygoni Cuspidati 21.6 parts, Rhizoma Polygonati Odorati 36 parts, Radix Glehniae 21.6 parts, Fructus Psoraleae 21.6
Part, Radix Aconiti Lateralis Preparata 7.2 parts, the Radix Astragali 21.6 parts, 21.6 parts of Rhizoma Curcumae Longae, Radix Adenophorae 21.6 parts, Herba Epimedii 36 parts and 7.2 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation for the treatment of chronic cardiopulmonary disease the most according to claim 1, described Chinese medicine preparation
Dosage form is tablet, it is characterised in that preparation method comprises the following steps:
1. Radix Salviae Miltiorrhizae powder is broken into fine powder, standby；
2. remaining medical material in described Chinese medicine preparation is mixed in proportion, boiling secondary, merges decoction liquor, filter, will
Filtrate is condensed into the clear paste that relative density is 14 ° of B é, is spray-dried by clear paste；
3. putting in trough type mixing machine by Radix Salviae Miltiorrhizae fine powder and clear paste powder, mix homogeneously, is 80%～the ethanol solution system of 90% by concentration
Grain, is dried, and takes out, cools, and by dry granule granulate, the granule crossed by granulate is put in three-dimensional mixer, adds grain amount 0.5%
Magnesium stearate, mixing, take out, tabletting, coating, make.
The preparation method of the Chinese medicine preparation for the treatment of chronic cardiopulmonary disease the most according to claim 1, described Chinese medicine preparation
Dosage form is capsule, it is characterised in that distinguishing with method for preparing tablet thereof is that 3. step mixes for Radix Salviae Miltiorrhizae fine powder is put grooved with clear paste powder
In conjunction machine, add the ethanol solution that concentration is 75%～80%, after continuing stirring 8～10 minutes, make soft material, standby；More than repetition
Step 1 time；Pelletize, forced air drying under the conditions of 75 DEG C ± 5 DEG C；Start every about 2 hours to fall dish once to being dried, when granule water
Divide less than 7%, granulate, always mix, capsule is filled, and gets product.
5. according to the preparation method of the Chinese medicine preparation treating chronic cardiopulmonary disease described in claim 3 or 4, it is characterised in that described
Step 1. in fine powder all by 80 mesh sieves, and pass through 100 mesh sieves more than 95%.
6. according to the preparation method of the Chinese medicine preparation treating chronic cardiopulmonary disease described in claim 3 or 4, it is characterised in that described
In step 2. middle boiling secondary, first time amount of water is 9 times of medical material amount, decocts 4 hours, and amount of water is medical material for the second time
8 times of amount, decoct 3 hours.
7. according to the preparation method of the Chinese medicine preparation treating chronic cardiopulmonary disease described in claim 3 or 4, it is characterised in that described
During step 2. middle spray drying, spraying machine inlet temperature is 190 DEG C～220 DEG C, and outlet temperature is 90 DEG C～110 DEG C.
8. according to the preparation method of the Chinese medicine preparation treating chronic cardiopulmonary disease described in claim 3 or 4, it is characterised in that described
Step 3. middle granulation, granulate 14 mesh sieves.
The preparation method of the Chinese medicine preparation for the treatment of chronic cardiopulmonary disease the most according to claim 3, it is characterised in that described step
Rapid 3. middle ethanol solution consumption is the 15%～30% of Radix Salviae Miltiorrhizae fine powder and clear paste grain weight amount.
The preparation method of the Chinese medicine preparation for the treatment of chronic cardiopulmonary disease the most according to claim 4, it is characterised in that described step
Rapid 3. middle ethanol solution consumption is the 10%～20% of Radix Salviae Miltiorrhizae fine powder and clear paste grain weight amount.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737770A (en) * | 2022-12-08 | 2023-03-07 | 江苏七〇七天然制药有限公司 | Lung and heart clearing tablet and preparation method thereof |
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2016
- 2016-08-17 CN CN201610676016.3A patent/CN106215097A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 吕武清等: "《中成药中的药材薄层色谱鉴别》", 31 March 1997, 人民卫生出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737770A (en) * | 2022-12-08 | 2023-03-07 | 江苏七〇七天然制药有限公司 | Lung and heart clearing tablet and preparation method thereof |
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