CN104042649B - Ovate leaf holly bark and sulfamonomethoxine sodium containing compound composition for livestock and poultry - Google Patents
Ovate leaf holly bark and sulfamonomethoxine sodium containing compound composition for livestock and poultry Download PDFInfo
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Abstract
The invention relates to an ovate leaf holly bark and sulfamonomethoxine sodium containing compound composition for livestock and poultry. The compound composition comprises the following raw materials in parts by weight: 7-30 parts of sulfamonomethoxine sodium and 10-160 parts of ovate leaf holly bark. The raw materials are mixed uniformly to prepare powder, tablets, oral liquid or granules. The compound composition can reverse the resistance of bacteria to antibacterial drugs by being added to feeds for livestock and poultry according to 0.1-5g/kg of feed additive amount to feed the livestock and poultry, thus improving the treatment effects of the antibacterial drugs, substantially reducing the drug cost and creating higher economic benefits for farmers.
Description
The present invention is invention entitled filed on 03 18th, 2013 " a kind of to treat poultry escherichia coli containing Cortex Ilicis Rotundae
The compound catching ", the divisional application of Application No. 201310085603.1.
Technical field
The present invention relates to a kind of poultry compound containing Cortex Ilicis Rotundae and sulfamonomethoxine sodium.
Background technology
Escherichia coli are common conditioned pathogens, are also a kind of disease often sent out, you can primary cause the acute deteriorated blood of chicken
The multiple location severe infections such as disease, peritonitis, hepatitis, pneumonia, enteritis, also can secondary or mixed send out in virosiss, cause to aquaculture
Huge economic loss.Wherein amoxicillin, ampicillin, ceftiofur, ceftriaxone, amoxicillin/clavulanate, ammonia benzyl
The beta-lactam nucleus class antibiotic such as XiLin/sulbactam is the conventional important drugs preventing and treating this disease, intensive with cultivation scale
Degree is more and more big, and medication is more and more spread unchecked, and its Resistant strain is more and more many, reports more, mesh with regard to Drug Resistance of E. coli
Front research confirms that one of main mechanism of drug resistance is to produce beta-lactamase, especially extended spectrumβ-lactamase (extended-
Spectrum β-lactamase, esbls), relatively strong and quickly can hydrolyze beta-lactam nucleus, make this kind of antibiotic lose antibacterial
Activity.Esbls is the main enzyme type of beta-lactamase, esbls not only to cephalo three generations and aztreonam drug resistance, and to amino
Glucosides class, quinolones and sulfonamides are in crossing drug resistant, only to carbapenemss, a mould alkenes medicaments insensitive.Many literary compositions at present
Offer it has been reported that colibacillary multi-drug resistant has substantial connection with producing esbls, both at home and abroad it is more paid close attention to.To part
The colibacillary drug sensitive test of esbls shows, its multidrug resistant rate is apparently higher than non-esbls bacterial strain.In addition result also shows to produce
The esbls bacterial strain not only serious drug resistance to third generation cephalosporins such as ceftiofurs, and also to fluoroquinolones, aminoglycoside
With multiple antimicrobial drug drug resistances such as sulfonamides, in serious multidrug resistant, colibacillary drug resistance causes to become to raiser's medication
This increase, the course for the treatment of of treatment extends, and mortality of livestock increases, and brings higher expenses for medicine cost and economic loss to producing.Therefore,
In actual production anxious wait to need a kind of to regardless of whether the escherichia coli of drug resistance can have the medicine of preferable therapeutical effect, to shorten
The course for the treatment of of treatment, reduces mortality rate, reduces economic loss, is that raiser creates higher economic benefit.
Content of the invention
It is an object of the invention to provide a kind of poultry compound containing Cortex Ilicis Rotundae and sulfamonomethoxine sodium,
Antibacterial can be killed quickly, overcome the weak curative effect that antimicrobial drug treatment caused due to drug resistance problems, consumption is big, residual is high and becomes
This high defect.
The present invention is achieved through the following technical solutions above-mentioned purpose: a kind of containing Cortex Ilicis Rotundae and sulfamonomethoxine sodium
Poultry compound, is made up of the raw material of following weight ratio: sulfamonomethoxine sodium 7-30 part, Cortex Ilicis Rotundae 10-
160 parts.
The compound method of described compound is: Cortex Ilicis Rotundae is pulverized, cross 60 mesh sieves after, then with powder
Antimicrobial drug is put in blender according to described parts by weight of raw materials ratio and is mixed, and is prepared into powder, tablet, oral liquid or granule
Agent.
The present invention is compared with prior art had the beneficial effect that after adding Cortex Ilicis Rotundae in antimicrobial drug, can be inverse
Turning the drug resistance of bacteria medicine, thus improving the therapeutic effect of antimicrobial drug, drug cost is greatly reduced, be raiser's creation
Higher economic benefit.
Specific embodiment:
Antimicrobial drug has the colibacillary effect for the treatment of in itself, but has due to producing the escherichia coli of esbls drug resistant gene
Stronger drug resistance, causes antimicrobial drug not show preferable therapeutic effect in the case of normal using dosage.
In order to verify the drug resistance inversion effect to antimicrobial drug for the Cortex Ilicis Rotundae, applicant adopts two times of microtest tube on 96 orifice plates
Dilution method, first determines antimicrobial drug to the minimal inhibitory concentration producing esbls e. coli strains and Cortex Ilicis Rotundae to product esbls large intestine bar
The subinhibitory concentration of bacterial strain, then adds the Cortex Ilicis Rotundae of subinhibitory concentration to reuse microtest tube doubling dilution in the medium
The minimal inhibitory concentration of method culture assay antimicrobial drug；Using continuous passage method added with same subinhibitory concentration Cortex Ilicis Rotundae and same
In the culture medium of concentration antimicrobial drug, Secondary Culture is carried out to product esbls e. coli strains, until the minimum suppression of the antimicrobial drug observing
Bacteria concentration before passing on compared with diminish more than 4 times, you can be judged as Cortex Ilicis Rotundae antibacterial medical instrument is had drug resistance inversion act on.Test knot
Fruit counts as shown in the table:
Subinhibitory concentration Cortex Ilicis Rotundae culture medium passes on and causes the change producing esbls escherichia coli antimicrobial drug minimal inhibitory concentration
(ug/ml)
As seen from the above table, antimicrobial drug all reduces more than 4 times to producing the colibacillary minimal inhibitory concentration of esbls, you can sentence
Break and to producing esbls escherichia coli, there is drug resistance inversion effect for Cortex Ilicis Rotundae.
In order to further illustrate technical scheme, applicant carried out embodiment in detail below:
Embodiment 1
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 3 parts of amoxicillin, 180 parts of Cortex Ilicis Rotundae.
Embodiment 2
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 10 parts of amoxicillin, 90 parts of Cortex Ilicis Rotundae.
Embodiment 3
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 3 parts of amoxicillin, 40 parts of Cortex Ilicis Rotundae.
Embodiment 4
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 20 parts of amoxicillin, 40 parts of Cortex Ilicis Rotundae.
Embodiment 5
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 3 parts of norfloxacin, 190 parts of Cortex Ilicis Rotundae.
Embodiment 6
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 12 parts of norfloxacin, 120 parts of Cortex Ilicis Rotundae.
Embodiment 7
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 25 parts of levofloxacin, 30 parts of Cortex Ilicis Rotundae.
Embodiment 8
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 25 parts of norfloxacin, 190 parts of Cortex Ilicis Rotundae.
Embodiment 9
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 3 parts of LIJUNJING, 200 parts of Cortex Ilicis Rotundae.
Embodiment 10
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 6 parts of LIJUNJING, 100 parts of Cortex Ilicis Rotundae.
Embodiment 11
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 15 parts of LIJUNJING, 50 parts of Cortex Ilicis Rotundae.
Embodiment 12
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 15 parts of LIJUNJING, 200 parts of Cortex Ilicis Rotundae.
Embodiment 13
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 14 parts of sulfamonomethoxine sodium, 10 parts of Cortex Ilicis Rotundae.
Embodiment 14
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 7 parts of sulfamonomethoxine sodium, 160 parts of Cortex Ilicis Rotundae.
Embodiment 15
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 30 parts of sulfamonomethoxine sodium, 5 parts of Cortex Ilicis Rotundae.
Embodiment 16
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 30 parts of sulfamonomethoxine sodium, 160 parts of Cortex Ilicis Rotundae.
Embodiment 17
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 12 parts of florfenicol, 40 parts of Cortex Ilicis Rotundae.
Embodiment 18
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 3 parts of florfenicol, 180 parts of Cortex Ilicis Rotundae.
Embodiment 19
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 20 parts of florfenicol, 10 parts of Cortex Ilicis Rotundae.
Embodiment 20
A kind of compound treating poultry coli-infection disease containing Cortex Ilicis Rotundae, by following weight ratio
Raw material forms: 20 parts of florfenicol, 180 parts of Cortex Ilicis Rotundae.
Above-described embodiment 1- embodiment 20 is prepared in accordance with the following methods: Cortex Ilicis Rotundae pulverized after 60 mesh sieves, based on
Raw material, then put into mixing in blender with the antimicrobial drug ratio by weight of powder, and embodiment 2,6,10,16 and 19 is made
Standby one-tenth powder；Embodiment 1,5,9,15 and 18 prepares piece agent, and embodiment 3,7,11,13 and 17 is prepared into oral liquid；Embodiment
4th, 8,12,14 and 20 it is prepared into granule.
In order to beneficial effect that the present invention can obtain is better described, applicant carried out following Application Example.
Application Example 1
The efficacy experiment to chicken escherichia coil disease for the compound of embodiment 1- embodiment 4 gained:
Clinical symptoms: Guangxi Yulin chicken house, 20 Day-old Broiler Chickens, sporadicly dead, cut open inspection indivedual chicken appearance bag in chicken group
Pericardium liver pathological change, typical bacillus coli feature.
Laboratory diagnosiss: take pathologic liver dye piece, Gram’s staining, basis of microscopic observation is it is seen that the gram-negative of redness
Property bacillus；Tentatively it is judged as bacillus coli.Cultivated by escherichia coli, biochemical test differentiates, judge that chicken infects for big
Enterobacteria disease, pcr amplification is it was demonstrated that produce the esbls drug resistant gene having tem type.
Test therapeutic regimen: morbidity chicken group is divided into 6 groups of administrations, first group with embodiment 1 adding according to 6.3g/kg feedstuff
Dosage is administered, and second group is administered according to the addition of 1.2g/kg feedstuff with embodiment 2, and the 3rd group with embodiment 3 according to 1.7g/
The addition administration of kg feedstuff, the 4th group is administered according to the addition of 0.3g/kg feedstuff with embodiment 4；Use A Moxi for 5th group
Woods powder according to 0.12g/kg feedstuff addition be administered, the 6th group with the thick powder of Cortex Ilicis Rotundae according to 1.08g/kg feedstuff interpolation
Amount administration；Above six groups of therapeutic regimens are all persistently using 5 days.
Staining effect: after first group to the 4th group of chicken group's medication, diseased chicken feed intake rises, and dead chicken no longer, continues
Using 3 days, chicken group be almost recovered；After 5th group of chicken group's medication 2 days, chicken group's majority is still unhealthy, still has indivedual chicken deaths, continues
Continuous use 3 days, chicken death phenomenon is still without being effectively controlled；After 6th group of chicken group's medication 2 days, too not big bright of chicken group
Aobvious take on a new look, be continuing with 3 days, chicken death phenomenon is still without being effectively controlled.It can be seen that the compound containing Cortex Ilicis Rotundae is treated
Effect is better than folk prescription.
Application Example 2
The efficacy experiment to diarrhea of weaned piglets for the compound of embodiment 9- embodiment 12 gained:
Clinical symptoms: Nanning pig farm, 36 age in days ablactational baby pig, this swinery, after wean is turn-taked, starts abdomen
Rush down, draw watery stools, feces contain indigested feedstuff, pig material feeding but be exactly not long, serious individually diarrhea of pigs dehydration is dead,
Symptoms of emesis does not occur, raiser uses multi-medicament, ideal effect all in treatment.
Cut open inspection pathological changes: than more serious it is seen that eyes sink, after cut open inspection, Intestinum Sus domestica wall is belittled, especially after small intestinal for sick dead pig dehydration
End and colon site, intestinal mucosa comes off, and intestinal wall is congested, bleeding.
Laboratory diagnosiss: take pathologic liver dye piece, Gram’s staining, basis of microscopic observation is it is seen that the gram-negative of redness
Property bacillus；Tentatively it is judged as bacillus coli.Cultivated by escherichia coli, biochemical test differentiates, judges that Infection in Piglets is big
Enterobacteria disease, pcr amplification is it was demonstrated that produce the esbls drug resistant gene having ctx-m type.
Test therapeutic regimen: morbidity swinery divides 6 groups of administrations, first group with embodiment 9 according to 13g/kg feedstuff addition
Administration, second group is administered according to the addition of 3g/kg feedstuff with embodiment 10, is raised according to 0.8g/kg with embodiment 11 for the 3rd group
The addition administration of material, the 4th group is administered according to the addition of 2.7g/kg feedstuff with embodiment 12；Use LIJUNJING powder for 5th group
According to the addition administration of 0.2g/kg feedstuff, the 6th group is administered according to the addition of 13g/kg feedstuff with the thick powder of Cortex Ilicis Rotundae；With
Upper six groups of therapeutic regimens are all persistently using 5 days.
Using effect is fed back: after first group to the 4th group piglet medication 3 days, swinery no longer draws watery stools, formed stools,
No longer contain feedstuff in feces, be continuing with 2 days, swinery is fully recovered；After 5th group of medication 3 days, swinery is still unhealthy, is continuing with
2 days, substantially get well, but still draw pasty state feces individually, but after being discontinued 6 days, recurrence in swinery；6th group of medication 3 days
Afterwards, swinery no remarkable improvement, is continuing with 2 days, sporadic deaths, and remaining still draws individually pasty state feces.It can be seen that containing Cortex Ilicis Rotundae
Compound to swinery curative effect be better than folk prescription LIJUNJING and folk prescription Cortex Ilicis Rotundae.
Application Example 3
The efficacy experiment of the meat-type duck diarrhoea to 20 ages in days for the compound of embodiment 5- embodiment 8 gained:
Clinical symptoms: Nanning duck field, 20 age in days meat-type duck, duck group draws watery stools, has and significantly do not disappear in feces
The feedstuff changed.Duck group material feeding but not long, it is soft slowly dead that foot gradually in the serious ducks of indivedual diarrhoea.
Cut open inspection pathological changes: the duck that dies of illness dehydration ratio is more serious, and indivedual ducks are still very big, duck liver enlargement, hyperemia, the liver of part duck
White films are had, air bag is muddy, tentative diagnosis is escherichia coli on dirty.
Test therapeutic regimen: morbidity duck group divides seven groups of administrations, first group with embodiment 5 according to 9g/kg feedstuff addition
Administration, second group is administered according to the addition of 1.4g/kg feedstuff with embodiment 6, is raised according to 0.3g/kg with embodiment 7 for the 3rd group
The addition administration of material, the 4th group is administered according to the addition of 1.2g/kg feedstuff with embodiment 8；Use norfloxacin powder for 5th group
Agent is administered according to the addition of 0.15g/kg feedstuff, and the 6th group of levofloxacin powder is according to the addition of 0.13g/kg feedstuff
Administration, the 7th group is administered according to the addition of 1.27g/kg feedstuff with the thick powder of Cortex Ilicis Rotundae；Above seven groups of therapeutic regimens are all lasting
Using 5 days.
Using effect is fed back: after first group to the 4th group medication 2 days, sick duck no longer draws watery stools, formed stools, no longer
Dead duck occurs, is continuing with 3 days, duck group be almost recovered；After 5th group and the 6th group of medication 2 days, duck group's DeGrain, a lot
Still draw watery stools, containing indigested feedstuff, be continuing with 3 days, somewhat take a turn for the better, but not good thorough, dilute water sample
Feces still occur, and raiser cannot be discontinued to this two groups of ducks, have to use the compound of embodiment 6 gained instead, continue to make
With 2 days, just it is almost recovered, reuses 1 day, feces all switch to normally；After 7th group of medication 2 days, too not big obvious of duck
Take on a new look, be continuing with 3 days, the duck phenomena of mortality are still without being effectively controlled.It can be seen that the compound containing Cortex Ilicis Rotundae is to duck
Colibacillary curative effect is better than folk prescription.
Application Example 4
The efficacy experiment of the broiler diarrhoea to 25 ages in days for the compound of embodiment 13-16 gained:
Clinical symptoms: Liuzhou chicken house, 25 Day-old Broiler Chickens, chicken group draws watery stools, has and significantly do not disappear in feces
The feedstuff changed.It is soft slowly dead that foot gradually in the serious chicken of indivedual diarrhoea.
Cut open inspection pathological changes: the chicken that dies of illness dehydration ratio is more serious, Hepar Gallus domesticus enlargement, hyperemia have white films, air bag on the liver of part chicken
Muddiness, tentative diagnosis is escherichia coli.
Test therapeutic regimen: morbidity chicken group divides six groups of administrations, first group with embodiment 13 according to 2.7g/kg feedstuff interpolation
Amount administration, second group is administered according to the addition of 35g/kg feedstuff with embodiment 14, and the 3rd group with embodiment 15 according to 1.6g/kg
The addition administration of feedstuff, the 4th group is administered according to the addition of 10g/kg feedstuff with embodiment 16；5th group with first between sulfanilamide
Oxygen pyrimidine sodium powder agent is administered according to the addition of 2g/kg feedstuff, and the 6th group with Cortex Ilicis Rotundae thick powder adding according to 35g/kg feedstuff
Dosage is administered；Above six groups of therapeutic regimens are all persistently using 5 days.
Using effect is fed back: after first group to the 4th group medication 3 days, diseased chicken no longer draws watery stools, formed stools, no longer
Dead chicken occurs, is continuing with 2 days, chicken group be almost recovered；After 5th group of medication 3 days, chicken group's DeGrain, much still draws water
Sample feces, containing indigested feedstuff, are continuing with 2 days, somewhat take a turn for the better, but not good thorough, and dilute watery stools are still
Occur, raiser uses the compound of embodiment 16 gained instead, is continuing with 3 days, and feces all switch to normally；6th group of use
After medicine 3 days, chicken does not have too big remarkable improvement, is continuing with 2 days, and chicken death phenomenon is still without being effectively controlled.It can be seen that containing
The compound having Cortex Ilicis Rotundae is better than folk prescription to the curative effect of chicken colibacillosis.
Application Example 5
The efficacy experiment of the piglet diarrhea to 40 ages in days for embodiment 17- embodiment 20 compound:
Clinical symptoms: Nanning pig farm, 40 age in days piglets, this swinery, after wean is turn-taked, starts diarrhoea, draws
Watery stools, feces contain indigested feedstuff, pig material feeding but be exactly not long, serious individually diarrhea of pigs dehydration is dead, does not have
Symptoms of emesis occurs, raiser uses multi-medicament, ideal effect all in treatment.
Cut open inspection pathological changes: after cut open inspection, Intestinum Sus domestica wall is belittled, especially small intestinal rear end and colon site, and intestinal mucosa comes off, intestinal wall hyperemia,
Bleeding.
Laboratory diagnosiss: take pathologic liver dye piece, Gram’s staining, basis of microscopic observation is it is seen that the gram-negative of redness
Property bacillus；Tentatively it is judged as bacillus coli.Cultivated by escherichia coli, biochemical test differentiates, judge that pigletss infect for big
Enterobacteria disease, pcr amplification is it was demonstrated that produce the esbls drug resistant gene having oxa type.
Test therapeutic regimen: morbidity swinery divides 6 groups of administrations, first group with embodiment 17 according to 1g/kg feedstuff addition
Administration, second group is administered according to the addition of 15g/kg feedstuff with embodiment 18, is raised according to 0.4g/kg with embodiment 19 for the 3rd group
The addition administration of material, the 4th group is administered according to the addition of 2.4g/kg feedstuff with embodiment 20；Use florfenicol powder for 5th group
Agent is administered according to the addition of 0.3g/kg feedstuff, and the 6th group is administered according to the addition of 15g/kg feedstuff with the thick powder of Cortex Ilicis Rotundae；
Above six groups of therapeutic regimens are all persistently using 5 days.
Using effect is fed back: after first group to the 4th group medication 2 days, swinery no longer draws watery stools, formed stools, feces
In no longer contain feedstuff, be continuing with 3 days, swinery fully recover；After 5th group of medication 2 days, swinery is still unhealthy, is continuing with 3 days,
Substantially get well, but still draw pasty state feces individually, but after being discontinued 3 days, recurrence in swinery；After 6th group of medication 2 days, pig
Group's no remarkable improvement, is continuing with 3 days, swinery continues to have loose bowels, remaining is individually also than more serious.It can be seen that the compound recipe containing Cortex Ilicis Rotundae
Compositionss are better than folk prescription florfenicol and folk prescription Cortex Ilicis Rotundae to swinery curative effect.
Claims (1)
1. a kind of poultry compound containing Cortex Ilicis Rotundae and sulfamonomethoxine sodium is it is characterised in that by following heavy
The raw material composition of amount part ratio: sulfamonomethoxine sodium 7-30 part, Cortex Ilicis Rotundae 10-160 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410272441.7A CN104042649B (en) | 2013-03-18 | 2013-03-18 | Ovate leaf holly bark and sulfamonomethoxine sodium containing compound composition for livestock and poultry |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310085603.1A CN103127507B (en) | 2013-03-18 | 2013-03-18 | A kind of compound containing Cortex Ilicis Rotundae treatment poultry coli-infection disease |
| CN201410272441.7A CN104042649B (en) | 2013-03-18 | 2013-03-18 | Ovate leaf holly bark and sulfamonomethoxine sodium containing compound composition for livestock and poultry |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310085603.1A Division CN103127507B (en) | 2013-03-18 | 2013-03-18 | A kind of compound containing Cortex Ilicis Rotundae treatment poultry coli-infection disease |
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