CN104039794B - 7‑位取代的汉防己乙素衍生物、及其制备方法和应用 - Google Patents

7‑位取代的汉防己乙素衍生物、及其制备方法和应用 Download PDF

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Publication number
CN104039794B
CN104039794B CN201380004935.0A CN201380004935A CN104039794B CN 104039794 B CN104039794 B CN 104039794B CN 201380004935 A CN201380004935 A CN 201380004935A CN 104039794 B CN104039794 B CN 104039794B
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China
Prior art keywords
substituted
tetrandrine
optionally substituted
pharmaceutically acceptable
substituent
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Expired - Fee Related
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CN201380004935.0A
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English (en)
Chinese (zh)
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CN104039794A (zh
Inventor
荣风光
徐荣臻
赖洪喜
谢福文
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Priority to CN201380004935.0A priority Critical patent/CN104039794B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380004935.0A 2012-01-21 2013-01-21 7‑位取代的汉防己乙素衍生物、及其制备方法和应用 Expired - Fee Related CN104039794B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201380004935.0A CN104039794B (zh) 2012-01-21 2013-01-21 7‑位取代的汉防己乙素衍生物、及其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2012070698 2012-01-21
CNPCT/CN2012/070698 2012-01-21
CN201380004935.0A CN104039794B (zh) 2012-01-21 2013-01-21 7‑位取代的汉防己乙素衍生物、及其制备方法和应用
PCT/CN2013/070800 WO2013107428A1 (zh) 2012-01-21 2013-01-21 7-位取代的汉防己乙素衍生物、及其制备方法和应用

Publications (2)

Publication Number Publication Date
CN104039794A CN104039794A (zh) 2014-09-10
CN104039794B true CN104039794B (zh) 2017-11-03

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CN201380004935.0A Expired - Fee Related CN104039794B (zh) 2012-01-21 2013-01-21 7‑位取代的汉防己乙素衍生物、及其制备方法和应用

Country Status (6)

Country Link
US (1) US9328122B2 (enExample)
EP (1) EP2805954B1 (enExample)
JP (1) JP6298768B2 (enExample)
CN (1) CN104039794B (enExample)
DK (1) DK2805954T3 (enExample)
WO (1) WO2013107428A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016023404A1 (zh) * 2014-08-15 2016-02-18 贵州省中国科学院天然产物化学重点实验室 双苄基异喹啉衍生物、其制备方法及其在肝病的治疗与预防中的用途
CN107033157B (zh) * 2016-02-03 2020-05-05 贵州省中国科学院天然产物化学重点实验室 双苄基异喹啉衍生物及其在制备用于治疗或预防肿瘤的药物中的用途
CN109776553B (zh) * 2019-01-15 2020-05-29 山东师范大学 福己素及其制备方法和应用
CN110156808B (zh) * 2019-06-21 2022-01-18 华中农业大学 具有杀菌活性的防己诺林碱-氨基甲酸酯类衍生物
CN111675716B (zh) * 2020-06-15 2022-09-13 山东省农业科学院农产品研究所 一种具有抗癌活性的防己诺林碱衍生物及制备方法、应用
CN112250690B (zh) * 2020-09-24 2022-07-15 山东师范大学 磺酰基防己诺林碱类化合物及其制备方法和应用
CN114031623B (zh) * 2021-11-12 2023-04-11 山西医科大学 一种c14位氨基取代粉防己碱衍生物及其制备和应用
CN116731031A (zh) * 2023-06-16 2023-09-12 贵州药法自然医药科技有限公司 芬氏唐松草碱衍生物及其应用
WO2026105158A1 (en) * 2024-11-16 2026-05-21 Translational Health Science And Technology Institute Bis(benzylisoquinoline) alkaloids as tlr4 agonist
CN119792287B (zh) * 2025-03-17 2025-08-08 山东第二医科大学 防己诺林碱在制备stag2突变急性髓系白血病治疗药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293196A (zh) * 2000-09-08 2001-05-02 华西医科大学药物研究所 双苄基异喹啉类生物碱及其制备方法和药物组合物
CN1511527A (zh) * 2002-12-31 2004-07-14 北京大学第一医院 粉防已碱在抑制血管生成药物中的应用
CN101371839A (zh) * 2008-10-08 2009-02-25 中国科学院化学研究所 双苄基异喹啉类生物碱的新用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678232B2 (ja) * 1986-03-07 1994-10-05 株式会社ツムラ アンジオテンシンｉ転換酵素阻害剤
JPH02134382A (ja) * 1988-11-14 1990-05-23 Kaken Shiyouyaku Kk ビスベンジルイソキノリン誘導体
JPH02243627A (ja) * 1989-03-16 1990-09-27 Tsumura & Co 狭心症治療薬
CN1511528A (zh) 2002-12-30 2004-07-14 北京大学第一医院 防己诺林碱在抑制血管生成药物中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293196A (zh) * 2000-09-08 2001-05-02 华西医科大学药物研究所 双苄基异喹啉类生物碱及其制备方法和药物组合物
CN1511527A (zh) * 2002-12-31 2004-07-14 北京大学第一医院 粉防已碱在抑制血管生成药物中的应用
CN101371839A (zh) * 2008-10-08 2009-02-25 中国科学院化学研究所 双苄基异喹啉类生物碱的新用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Structure and hypotensive activity relationships of tetrandrine derivatives in stroke-prone spontaneously hypertensive rats;Koichiro Kawashima, et al.,;《General Pharmacology》;19901231;第21卷(第3期);第343-347页 *
アンジオテンシン1 変換酵素阻害作用を有する生薬の研究（第3 報）， 粉防已中の成分およびその誘導体の活性について;荻野達則，等，;《Nature Medicine》;19981231;第52卷(第2期);第172-178页 *

Also Published As

Publication number Publication date
JP2015504075A (ja) 2015-02-05
CN104039794A (zh) 2014-09-10
US20140357647A1 (en) 2014-12-04
US9328122B2 (en) 2016-05-03
EP2805954B1 (en) 2019-06-19
EP2805954A4 (en) 2015-10-21
JP6298768B2 (ja) 2018-03-20
EP2805954A1 (en) 2014-11-26
WO2013107428A1 (zh) 2013-07-25
DK2805954T3 (da) 2019-09-23

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Granted publication date: 20171103

Termination date: 20220121