CN104039175A - 使用非消化性低聚糖的变态反应疗法 - Google Patents
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
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- Immunology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/NL2011/050721 WO2013062402A1 (fr) | 2011-10-24 | 2011-10-24 | Traitement contre les allergies comprenant un oligosaccharide non digestible |
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CN104039175A true CN104039175A (zh) | 2014-09-10 |
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CN201180075877.1A Pending CN104039175A (zh) | 2011-10-24 | 2011-10-24 | 使用非消化性低聚糖的变态反应疗法 |
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Country | Link |
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EP (1) | EP2770854A1 (fr) |
CN (1) | CN104039175A (fr) |
WO (1) | WO2013062402A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109874291A (zh) * | 2016-09-13 | 2019-06-11 | 雀巢产品技术援助有限公司 | 用于具有牛乳蛋白质变应性的个体的发酵的营养组合物 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US10034937B2 (en) | 2015-12-04 | 2018-07-31 | Mead Johnson Nutrition Company | Synergistic nutritional compositions and uses thereof |
AU2018229814B2 (en) * | 2017-03-08 | 2023-06-01 | N.V. Nutricia | Composition with non-digestible oligosaccharides for attenuating nasal epithelial inflammation |
EP3672600A4 (fr) | 2017-08-21 | 2021-05-19 | Glycom A/S | Composition synthétique pour réduire les symptômes d'allergie |
FR3120788B1 (fr) * | 2021-03-22 | 2024-04-19 | Ophtalmis | Composition nutraceutique pour le traitement et la prevention des troubles oculaires |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101801220A (zh) * | 2007-06-15 | 2010-08-11 | 努特里希亚公司 | 含有非活的双歧杆菌和非消化性寡糖的营养物 |
WO2010143940A1 (fr) * | 2009-06-12 | 2010-12-16 | N.V. Nutricia | Mélange synergique de bêta-galacto-oligosaccharides avec des liaisons bêta-1,3 et bêta-1,4/1,6 |
CN101951794A (zh) * | 2007-12-21 | 2011-01-19 | N.V.努特里奇亚 | 鞘髓磷脂和非消化性碳水化合物改善肠道微生物群的用途 |
WO2011090926A1 (fr) * | 2010-01-19 | 2011-07-28 | Abbott Laboratories | Formules nutritionnelles contenant des synbiotiques |
-
2011
- 2011-10-24 WO PCT/NL2011/050721 patent/WO2013062402A1/fr active Application Filing
- 2011-10-24 EP EP11785146.9A patent/EP2770854A1/fr not_active Withdrawn
- 2011-10-24 CN CN201180075877.1A patent/CN104039175A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101801220A (zh) * | 2007-06-15 | 2010-08-11 | 努特里希亚公司 | 含有非活的双歧杆菌和非消化性寡糖的营养物 |
CN101951794A (zh) * | 2007-12-21 | 2011-01-19 | N.V.努特里奇亚 | 鞘髓磷脂和非消化性碳水化合物改善肠道微生物群的用途 |
WO2010143940A1 (fr) * | 2009-06-12 | 2010-12-16 | N.V. Nutricia | Mélange synergique de bêta-galacto-oligosaccharides avec des liaisons bêta-1,3 et bêta-1,4/1,6 |
WO2011090926A1 (fr) * | 2010-01-19 | 2011-07-28 | Abbott Laboratories | Formules nutritionnelles contenant des synbiotiques |
Non-Patent Citations (2)
Title |
---|
G MORO 等: "A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age", 《ARCHIVES OF DISEASE IN CHILDREN》, 27 July 2006 (2006-07-27), pages 814 - 820 * |
SERTAC ARSLANOGLU 等: "Early Dietary Intervention with a Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Allergic Manifestations and Infections during the First Two Years of Life", 《THE JOURNAL OF NUTRITION》, vol. 138, no. 6, 30 June 2008 (2008-06-30), pages 1091 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109874291A (zh) * | 2016-09-13 | 2019-06-11 | 雀巢产品技术援助有限公司 | 用于具有牛乳蛋白质变应性的个体的发酵的营养组合物 |
CN109874291B (zh) * | 2016-09-13 | 2023-10-27 | 雀巢产品有限公司 | 用于具有牛乳蛋白质变应性的个体的发酵的营养组合物 |
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WO2013062402A1 (fr) | 2013-05-02 |
EP2770854A1 (fr) | 2014-09-03 |
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