CN104027612A - Traditional Chinese medicine preparation for treating arrhythmia - Google Patents
Traditional Chinese medicine preparation for treating arrhythmia Download PDFInfo
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- CN104027612A CN104027612A CN201310085014.3A CN201310085014A CN104027612A CN 104027612 A CN104027612 A CN 104027612A CN 201310085014 A CN201310085014 A CN 201310085014A CN 104027612 A CN104027612 A CN 104027612A
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Abstract
The invention provides a traditional Chinese medicine preparation for treating arrhythmia and a preparation method thereof. The traditional Chinese medicine preparation is prepared from 30-100 parts by weight of bitter orange, 30-100 parts of tangerine pith, 30-100 parts of bamboo shavings, 30-100 parts of mother-of-pearl, 9-30 parts of coptis root, 9-30 parts of phellodendron, 9-30 parts of snakegourd fruit and 7-20 parts of seed of cowherb. The traditional Chinese medicine preparation is prepared based on the differential treatment of the Chinese medical science, realizes whole regulation and has effects of regulating qi-flowing for eliminating phlegm, clearing heart and calming nerves, calming patient mind and recovering heart rate and keeping human body health.
Description
Technical field
The invention provides a kind of ARR Chinese medicine preparation and preparation method thereof for the treatment of.
Background technology
Arrhythmia is the abnormal of the speed of heartbeat or the rhythm and pace of moving things, often has conducting system of heart extremely to cause.Arrhythmia refers to that heart beating is undesired, is exactly irregular heartbeats (eartbeat interval length different), but the frequency of heart beating is too fast or to cross be also arrhythmia slowly traditionally.Now larger for ARR treatment difficulty, to patient, caused larger misery.
Summary of the invention
The invention provides a kind of ARR Chinese medicine preparation for the treatment of, the present invention is based on motherland's medical science determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, from integrally-regulated, start with, and activating QI to eliminate phlegm, clearing away heart-fire for tranquillization; Make patient ataraxy, the multiple body peace of rule.
The present invention is achieved by the following technical solutions:
Treating an ARR Chinese medicine preparation, is to be made by the crude drug of following weight portion: Fructus Aurantii Immaturus 30-100 part, Vascular aurantii 30-100 part, Caulis Bambusae In Taenia 30-100 part, Concha Margaritifera 30-100 part, Rhizoma Coptidis 9-30 part, Cortex Phellodendri 9-30 part, Fructus Trichosanthis 9-30 part, Semen Vaccariae 7-20 part.
The ARR Chinese medicine preparation of described treatment can be made conventional clinically various dosage forms, as tablet, granule, capsule, pill etc.
The preparation method of the described ARR Chinese medicine preparation for the treatment of is:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract 1～3 time, each 1～2 hour, collect volatile oil;
(2) merge above-mentioned decocting liquid, filter, it is 1.19～1.20 extractum that filtrate is concentrated into relative density;
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is more than 1.30 thick pastes;
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverize 80 mesh sieves, obtained drug powder, added conventional excipient substance, made tablet, granule, capsule, pill etc.
In prescription of the present invention, Caulis Bambusae In Taenia is monarch drug, and Fructus Aurantii Immaturus, Vascular aurantii are ministerial drug, and Concha Margaritifera, Rhizoma Coptidis, Bulbus Allii Macrostemonis, Cortex Phellodendri, Fructus Trichosanthis are adjuvant drug, and Semen Vaccariae is for making medicine, and the drug effect of each raw material is as follows:
Caulis Bambusae In Taenia: its sweet in the mouth, cold nature, attaches to the lung and stomach meridians.Effect is removing heat-phlegm, relieves restlessness and prevents vomiting.< < book on Chinese herbal medicine converges speech > >: " only medicine is oh also for the therapeutic method to keep the adverse QI flowing downwards for Caulis Bambusae In Taenia, removing heat-phlegm.As front Gu is controlled lung-heat heat very, cough with dyspnea, vomit sound of vomiting cold and heat and all cards of blood oozing from the body openings or subcuta neous tissue metrorrhagia.This medicine is sweet cold and fall, kind except bright all the burning hot mental disorders of sun be disease, the vertical peace of using, as all sick unprovoked gastric heat persons do not use.”
Fructus Aurantii Immaturus: its bitter in the mouth, pungent, sour, warm in nature, return spleen, stomach, large intestine channel.Effect is that dispelling the stagnated QI removes painful abdominal mass, transforming phlegm and dispersing accumulations.< < Sheng Nong's herbal classic > >: " main strong wind as numb bean hardship is itched, removes cold and heat knot in skin, dysentery relieving, and longue meat, sharp the five internal organs, QI invigorating is made light of one's life by commiting suicide.”
Vascular aurantii: its bitter in the mouth, property is flat, returns liver, spleen two warps.Effect dredging collateral, regulates the flow of vital energy, and reduces phlegm.The < < detailed outline > > that picks up any lost article from the road: " the stagnant gas of the meridian dredging, vessel-distension, drive flesh side film apposition expectorant, invigorates blood circulation.″
Concha Margaritifera: its salty in the mouth, cold in nature, return liver, heart channel.Effect is suppressing the hyperactive liver and subsiding YANG, calms the nerves, and arresting convulsion improving eyesight.< < Compendium of Materia Medica > >: " peace soul, the nebulousurine of passing out semen only, separate pox and treat poison.”
Rhizoma Coptidis: its bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, gallbladder, large intestine channel.Effect is heat clearing and damp drying, eliminating fire and detoxication.< < pearl sac > >: " it is with having six: eliminating heart-fire, and one also; Remove damp-heat in middle-JIAO, two also; All skin ulcers must be used, and three also; Curing rheumatism, four also; Control acute conjunctivitis and break out, five also; Only blood is seen at middle part, and six also.”
Cortex Phellodendri: its bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel.Effect is heat clearing and damp drying, and pathogenic fire purging is except steaming, detoxification sore treatment.< < Sheng Nong's herbal classic > >: " stagnation of pathogenic heat in main the five internal organs the intestines and stomach, jaundice, perianal abscess, stopping leak profit, woman's whitish metrorrhagia, acute vulva ulcer.”
Fructus Trichosanthis: its sweet in the mouth, micro-hardship, cold in nature, return lung, stomach, large intestine channel.Effect is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, loosening bowel to relieve constipation.< < Mingyi Bielu > >: " the main thoracic obstruction, moistening face color.”
Semen Vaccariae: its bitter in the mouth, property is flat, returns liver, stomach warp.Effect is promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome.< < Sheng Nong's herbal classic > >: " main incised wound, hemostasis is by pain.Go out thorn, except migratory arthralgia endogenous cold.”
Caulis Bambusae In Taenia removing heat-phlegm in prescription to be to effect a permanent cure, Fructus Aurantii Immaturus, Vascular aurantii activating QI to eliminate phlegm removing food stagnancy, and Concha Margaritifera is calmed the nerves, arresting convulsion, Rhizoma Coptidis, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, Fructus Trichosanthis removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, Semen Vaccariae promoting blood circulation to restore menstrual flow; All medicine compatibilities are rigorous, and monarch is had, and complement each other, and play altogether activating QI to eliminate phlegm, the merit of clearing away heart-fire for tranquillization; There is transforming phlegm and dispersing accumulations, relieving stuffiness of the chest by dispersing aggregation of pathogens, vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing, the effects such as arresting convulsion of calming the nerves, cure mainly qi depression to blood stasis, heart-fire is prosperous is the arrhythmia of main pathogenesis.During treatment, oral, every day 3 times, each 10 grams 15 days is a course for the treatment of, general four or can cure six courses for the treatment of.
The raw materials used medicine of Chinese medicine preparation of the present invention is all cheap and easy to get, and cost of manufacture is low, good effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1 preparation treatment ARR Chinese medicine preparation (granule)
Formula is: 30 grams of Fructus Aurantii Immaturuss, 30 grams of Vascular aurantiis, 30 grams of Caulis Bambusae In Taenia, 30 grams of Concha Margaritiferas, 9 grams of Rhizoma Coptidis, 9 grams of Cortex Phellodendris, 9 grams of Fructus Trichosanthis, 7 grams of Semen Vaccariae.
Preparation method is:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract each 1～2 hour 1～3 time;
(2) merge above-mentioned decocting liquid, filter, filtrate is concentrated into the extractum that relative density is 1.19～1.20 (60 ℃);
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is the above thick pastes of 1.30 (60 ℃);
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverized 80 mesh sieves, and obtained drug powder, and added 5% dextrin to mix rear dry granulation, granulate, obtains granule.(granulation, granulate are common process)
Embodiment 2 preparation treatment ARR Chinese medicine preparation (capsule)
Formula is: 60 grams of Fructus Aurantii Immaturuss, 60 grams of Vascular aurantiis, 60 grams of Caulis Bambusae In Taenia, 60 grams of Concha Margaritiferas, 18 grams of Rhizoma Coptidis, 18 grams of Cortex Phellodendris, 18 grams of Fructus Trichosanthis, 14 grams of Semen Vaccariae.
Preparation method is:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract each 1～2 hour 1～3 time;
(2) merge above-mentioned decocting liquid, filter, filtrate is concentrated into the extractum that relative density is 1.19～1.20 (60 ℃);
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is the above thick pastes of 1.30 (60 ℃);
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverized 80 mesh sieves, and obtained drug powder, and added 5% dextrin to mix rear dry granulation, granulate, incapsulates granule, makes capsule.
Embodiment 3 preparation treatment ARR Chinese medicine preparation (tablet)
Formula is: 50 grams of Fructus Aurantii Immaturuss, 50 grams of Vascular aurantiis, 50 grams of Caulis Bambusae In Taenia, 50 grams of Concha Margaritiferas, 20 grams of Rhizoma Coptidis, 20 grams of Cortex Phellodendris, 20 grams of Fructus Trichosanthis, 20 grams of Semen Vaccariae.
Preparation method is:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract each 1～2 hour 1～3 time;
(2) merge above-mentioned decocting liquid, filter, filtrate is concentrated into the extractum that relative density is 1.19～1.20 (60 ℃);
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is the above thick pastes of 1.30 (60 ℃);
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverize 80 mesh sieves, obtained drug powder, made tablet after adding 5% dextrin to mix.
Embodiment 4 preparation treatment ARR Chinese medicine preparation (pill)
Formula is: 90 grams of Fructus Aurantii Immaturuss, 90 grams of Vascular aurantiis, 90 grams of Caulis Bambusae In Taenia, 90 grams of Concha Margaritiferas, 30 grams of Rhizoma Coptidis, 30 grams of Cortex Phellodendris, 30 grams of Fructus Trichosanthis, 20 grams of Semen Vaccariae.
Preparation method is:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract 1～3 time, each 1～2 hour,
(2) merge above-mentioned decocting liquid, filter, filtrate is concentrated into the extractum that relative density is 1.19～1.20 (60 ℃);
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is the above thick pastes of 1.30 (60 ℃);
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverize 80 mesh sieves, obtained drug powder, made pill after adding 5% dextrin to mix.
Clinical data
Case 1 Lee so-and-so, man, 57 years old, 2006-08-06 first visit.
Main suit: in nervous February, increase the weight of one week.
Symptom: patient occurred nervous before February, be persistence, moving increase the weight of.Once in certain hospital admission, had an electro-cardiogram and showed: arrhythmia-Frequent atrial premature beats secondary.Within nearly one week, the symptom of having palpitation increases the weight of, with coming inventor to locate outpatient service.Existing patient is nervous, is persistence, movable rear uncomfortable in chest, shortness of breath and fatigue, poor appetite, little sleep disturbed by dreams, yellow urine, large loose stool.
Tongue arteries and veins: red tongue, greasy fur, deep pulse, knot generation.
History of past illness: 30 years provirus property myocarditis medical histories.
Auxiliary examination: ECG shows: arrhythmia-Frequent atrial premature beats secondary.
Diagnosis: arrhythmia-artrial premature beat.
Process: take the prepared medicine of embodiment 1, every day three times, each 10 grams, take 15 days courses for the treatment of.
2006-08-21 further consultation: transference cure, electrocardio diagram: normal ECG, continues to take half a year.
2007-08-22 pays a return visit: nervous symptom, normal ECG do not appear in patient.
Case 2 kings so-and-so, man, 55 years old, 2007-01-09 first visit.
Main suit: ictal March uncomfortable in chest, nervous.
Symptom: patient feel nearly March ictal uncomfortable in chest, have palpitation, breathe hard, the pulse of testing oneself has intermittently, once, in certain hospital admission, is diagnosed as frequent premature ventricular beats, takes metoprolol, 12.5mg, bid, effect is undesirable.Existing patient
While sending out during cardiopalmus, stop, frightened easy work, agitation uncomfortable in chest, insomnia and dreamful sleep, xerostomia is bitter, constipation, oliguria with reddish urine.
Tongue arteries and veins: red tongue with yellowish and greasy fur, stringy and rolling pulse, knot generation.
Auxiliary examination: ECG shows: frequent premature ventricular beats.
Diagnosis: arrhythmia-frequent premature ventricular beats.
Process: take the prepared medicine of embodiment 2, every day three times, each 10 grams, take 15 days courses for the treatment of.
2007-01-26 further consultation: transference cure, electrocardio diagram: normal ECG, continues to take half a year.
2008-09-28 pays a return visit: nervous symptom, normal ECG do not appear in patient.
Case 3 grandsons so-and-so, female, 63 years old, 2008-03-18 first visit.
Main suit: weak 6 months of nervous companion, increases the weight of 2 weeks.
Symptom: patient is nervous, weak over the past half year, angry postemphasis, in certain hospital treatment, symptom is not felt any better, and the present, inventor located outpatient service.The full vexed discomfort in existing patient ambition, dull pain paroxysm, migratory pain, in time, is wanted to heave a deep sigh, and easily bring out or increase the weight of, or it is vexed to have gastral cavity abdominal distention concurrently when chance feelings will is unsuccessful, obtains belch or vows that gas relaxes.
Tongue arteries and veins: red tongue with thin fur is greasy, thready and stringy pulse, knot generation.
Auxiliary examination: ECG shows: 1, frequent premature ventricular beats, 2, inferior myocardium is under ischemic-type, 3, old, rear wall myocardial infarction.
Diagnosis: 1, arrhythmia-frequent premature ventricular beats.2, under coronary heart disease-old, rear wall myocardial infarction.
Process: take the prepared medicine of embodiment 3, every day three times, each 10 grams, take 15 days courses for the treatment of.
2008-04-06 further consultation: transference cure, electrocardio diagram: normal ECG, continues to take half a year.
2009-04-16 pays a return visit: nervous symptom, normal ECG do not appear in patient.
Case 4 still so-and-so, female, 70 years old, 2009-06-06 first visit.
Main suit: be interrupted uncomfortable in chest, nervous 3 years, increase the weight of 1 week.
Symptom: patient is interrupted uncomfortable in chest, nervous nearly March, once at many hospital admissions, on ordinary days, takes " Propafenone, WENXIN KELI, Heart pill of Musk " treatment and can take a turn for the better when palpitation of the heart comes on.Before 1 week, after fatigue, occurred cardiopalmus, the symptom of breathing hard, take said medicine and alleviate not obviously, the present, inventor located outpatient service.Existing patient is uncomfortable in chest heavy and pained light, obesity, and abundant expectoration is breathed hard, and meet overcast and rainy and easily show effect or increase the weight of, with fatigue and weakness, indigestion and loss of appetite loose stool, mouthful sticky, feel sick, cough up the saliva of spitting.
Tongue arteries and veins: red tongue tongue is greasy in vain, rolling pulse, knot generation.
Auxiliary examination: ECG shows: sinus rhythm, the premature ventricular beat that takes place frequently (a position property, paired).
Diagnosis: arrhythmia-premature ventricular beat takes place frequently.
Process: take the prepared medicine of embodiment 4, every day three times, each 10 grams, take 15 days courses for the treatment of.
2009-06-26 further consultation: transference cure, electrocardio diagram: normal ECG, continues to take half a year.
2010-06-26 pays a return visit: nervous symptom, normal ECG do not appear in patient.
Claims (6)
1. the ARR Chinese medicine preparation for the treatment of, is characterized in that being made by the raw material of following weight proportion: Fructus Aurantii Immaturus 30-100 part, Vascular aurantii 30-100 part, Caulis Bambusae In Taenia 30-100 part, Concha Margaritifera 30-100 part, Rhizoma Coptidis 9-30 part, Cortex Phellodendri 9-30 part, Fructus Trichosanthis 9-30 part, Semen Vaccariae 7-20 part.
2. a kind of ARR Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: be to be made by the raw material of following weight proportion: 30 parts of Fructus Aurantii Immaturuss, 30 parts of Vascular aurantiis, 30 parts of Caulis Bambusae In Taenia, 30 parts of Concha Margaritiferas, 9 parts of Rhizoma Coptidis, 9 parts of Cortex Phellodendris, 9 parts of Fructus Trichosanthis, 7 parts of Semen Vaccariae.
3. a kind of ARR Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: be to be made by the raw material of following weight proportion: 60 parts of Fructus Aurantii Immaturuss, 60 parts of Vascular aurantiis, 60 parts of Caulis Bambusae In Taenia, 60 parts of Concha Margaritiferas, 18 parts of Rhizoma Coptidis, 18 parts of Cortex Phellodendris, 18 parts of Fructus Trichosanthis, 14 parts of Semen Vaccariae.
4. a kind of ARR Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: be to be made by the raw material of following weight proportion: 50 parts of Fructus Aurantii Immaturuss, 50 parts of Vascular aurantiis, 50 parts of Caulis Bambusae In Taenia, 50 parts of Concha Margaritiferas, 20 parts of Rhizoma Coptidis, 20 parts of Cortex Phellodendris, 20 parts of Fructus Trichosanthis, 20 parts of Semen Vaccariae.
5. a kind of ARR Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: be to be made by the raw material of following weight proportion: 90 parts of Fructus Aurantii Immaturuss, 90 parts of Vascular aurantiis, 90 parts of Caulis Bambusae In Taenia, 90 parts of Concha Margaritiferas, 30 parts of Rhizoma Coptidis, 30 parts of Cortex Phellodendris, 30 parts of Fructus Trichosanthis, 20 parts of Semen Vaccariae.
6. a kind of preparation method for the treatment of ARR Chinese medicine preparation described in any one in claim 1-5, is characterized in that, step is as follows:
(1) get Fructus Aurantii Immaturus, Vascular aurantii, Caulis Bambusae In Taenia, Concha Margaritifera, Rhizoma Coptidis, Cortex Phellodendri, Fructus Trichosanthis, Semen Vaccariae, add respectively water and be 8～12 times of quality of medicinal material, extract each 1～2 hour 1～3 time;
(2) merge above-mentioned decocting liquid, filter, it is 1.19～1.20 extractum that filtrate is concentrated into relative density;
(3) to adding 95% ethanol to alcohol content in extractum, be 60%, standing 24 hours; Get supernatant, filter, being concentrated into relative density is more than 1.30 thick pastes;
(4) by thick paste drying under reduced pressure at 60～80 ℃, pulverize 80 mesh sieves, obtained drug powder, added conventional excipient substance, made tablet, granule, capsule or pill.
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| CN201310085014.3A CN104027612A (en) | 2013-03-07 | 2013-03-07 | Traditional Chinese medicine preparation for treating arrhythmia |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101675982A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for warming heart yang and reducing phlegm and absorbing clots |
| CN102283940A (en) * | 2011-08-01 | 2011-12-21 | 山东中医药大学附属医院 | Chinese medicinal preparation for treating palpitation |
| CN102335358A (en) * | 2011-10-26 | 2012-02-01 | 成都绿迪科技有限公司 | Traditional Chinese medicine preparation for treating arrhythmia |
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2013
- 2013-03-07 CN CN201310085014.3A patent/CN104027612A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675982A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for warming heart yang and reducing phlegm and absorbing clots |
| CN102283940A (en) * | 2011-08-01 | 2011-12-21 | 山东中医药大学附属医院 | Chinese medicinal preparation for treating palpitation |
| CN102335358A (en) * | 2011-10-26 | 2012-02-01 | 成都绿迪科技有限公司 | Traditional Chinese medicine preparation for treating arrhythmia |
Non-Patent Citations (1)
| Title |
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