CN104027364B - Relieve the effect of alcohol Antrodia camphorata lozenge and preparation method thereof - Google Patents
Relieve the effect of alcohol Antrodia camphorata lozenge and preparation method thereof Download PDFInfo
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Abstract
Disclosed by the invention a kind of using Antrodia camphorata extract dry powder and L cysteines as the Antrodia camphorata lozenge that relieves the effect of alcohol of primary raw material, meter includes by weight：600 800 parts of Antrodia camphorata extract, 100 200 parts of L cysteines, 250 400 parts of filler, 50 100 parts of wetting agent, 1 20 parts of magnesium stearate.Antrodia camphorata active component and L cysteines are mutually coordinated, promote human body to the metabolism of alcohol, with obvious dispelling effects of alcohol, while having certain protective effect to liver.The present invention also provides the preparation method of the Antrodia camphorata lozenge that relieves the effect of alcohol, using Antrodia camphorata fructification or mycelium as raw material, the technique being combined using alcohol extracting and water extraction, at utmost extracts the active ingredient in Antrodia camphorata, utilization rate height.In addition easy to carry by the Antrodia camphorata lozenge that relieves the effect of alcohol obtained by science flaking method, simply eaten, process stabilizing is adapted to large-scale production.
Description
Technical field
The present invention relates to biological technical field, more particularly to one kind is relieved the effect of alcohol Antrodia camphorata lozenge and preparation method thereof.
Background technology
Excessive drinking and alcoholic are increasing in recent years, have a strong impact on healthy people and family, the stabilization of society.
Acute heavy drinking Nausea and vomiting, failure of memory, absent minded, fine movement ability can be caused impaired and mood not
It is stable, the possibly even causing death because of paralysis of respiratory muscle when serious.Long-term alcohol can cause phrenoblabia, gastric ulcer and fat
The diseases such as fat liver, alcoholic hepatitis, hepatic sclerosis, have data show cancer of the esophagus, onset of liver cancer rate rise also with drink it is relevant.
The alcohol 95% of human body intake is metabolized as acetaldehyde through alcohol dehydrogenase in vivo, and acetaldehyde is urged acetaldehyde dehydrogenase
Acetic acid is changed under change, acetic acid is further converted into acetyl coenzyme A, and acetyl coenzyme A can be decomposed into dioxy into tricarboxylic acid cycle
Change carbon, water and energy.Human body is limited to the tolerance of alcohol, can produce various ill symptomses, such as headache, Nausea and vomiting, polydipsia
Deng.Meanwhile, excessive acetaldehyde can also cause cell oxidative damage, cause the generation of a variety of diseases.
Antrodia is called Antrodia camphorata, is the medicinal fungi for originating in Taiwan, with great medical value, is described as " anticancer
Panacea " and " king of liver protection ", are also current price most expensive medicinal fungi.Antrodia camphorata is expensive, but existing Antrodia camphorata product
Active component utilization rate is low.In order to effectively eliminate the various adverse consequences drunk beyond one's capacity and caused, in the urgent need to development and production are a kind of
New product with good sober-up function.In the market there is also numerous disintoxicating products, such as alcohol-decomposing beverage, Antialcoholic tea, relieve the effect of alcohol
Oral liquid etc., most effect is not notable, and liquid beverage is inconvenient to carry for consumer, and is difficult long-term preservation.Although
Antrodia camphorata has the special effect of Antialcoholic liver-protecting, but people are low to the utilization rate of Antrodia camphorata active ingredient at present, and in the market there is no
Dedicated for the Antrodia camphorata product relieved the effect of alcohol.Therefore, prior art urgently improves.
The content of the invention
To overcome above the deficiencies in the prior art, the present invention provides a kind of active ingredient using height, and sober-up function is significant
Relieve the effect of alcohol Antrodia camphorata lozenge, and meter includes by weight：600-800 parts of Antrodia camphorata extract, 100-200 parts of Cys, fill out
Fill 250-400 parts of agent, 50-100 parts of wetting agent, 1-20 parts of magnesium stearate.
Further, the Antrodia camphorata extract is Antrodia camphorata water extract and the mixture of Antrodia camphorata alcohol extracting thing.
Further, the filler is at least one of mannitol, microcrystalline cellulose, lactose, starch and Icing Sugar.
Further, the wetting agent is absolute ethyl alcohol.
The present invention also provides the preparation method of described Antrodia camphorata Sobering-up buccal tablet, comprises the following steps：Antrodia camphorata is extracted
After thing, Cys and filler are well mixed, wetting agent softwood is added, the granulation of 18 mesh sieves makes pellet in 50-60 DEG C
At a temperature of dry 30-60 minute, into dried particle add magnesium stearate be well mixed, after 18 mesh sieve whole grains 3-10 public affairs
It is tabletted under the pressure of jin, obtain Antrodia camphorata lozenge.
Further, the Antrodia camphorata extract includes Antrodia camphorata water-phase extract；The Antrodia camphorata water-phase extract
Preparation process comprises the following steps：
Step A1：The water of 5-15 times of its volume is added in Antrodia camphorata raw material, is extracted 30-60 minutes at 80-95 DEG C,
Filtering, takes filtrate；
Step A2：Repeat step A1 is at least twice；Merge gained filtrate, obtain Antrodia camphorata aqueous extract；
Step A3：The Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 60-80 DEG C, then in 100-
Micro-wave vacuum is used at 120 DEG C, is crushed；Or, the Antrodia camphorata aqueous extract is concentrated in vacuo into concentration at 60-80 DEG C
Liquid, the spraying drying powder-forming at 100-120 DEG C；
Step A4：Powder obtained by step A3 is crossed into 80-200 mesh sieves, Antrodia camphorata water-phase extract is obtained.
Further, the Antrodia camphorata extract also includes Antrodia camphorata alcohol extracting thing；The system of the Antrodia camphorata alcohol extracting thing
Standby process comprises the following steps：
Step B1：Antrodia camphorata raw material after aqueous extraction of learning from else's experience, adds the absolute ethyl alcohol of 4-10 times of its volume,
Carried out at 80-90 DEG C 1-1.5 hour of backflow, filtrate is collected in filtering；
Step B2：Repeat step B1 is at least one times；Filtrate obtained by merging, obtains Antrodia camphorata alcohol extract；
Step B3：Volatilization removes the ethanol in the Antrodia camphorata alcohol extract, and micro-wave vacuum is crushed, and crosses 80-200
Mesh sieve, obtains powdered Antrodia camphorata ethanol extract.
Further, the Antrodia camphorata raw material is solid medium cultivation, solution fermentation or Antrodia camphorata obtained by linden cultivation
Fructification or mycelium.
The beneficial effects of the present invention are：The technique being combined using alcohol extracting and water extraction fully extracts Antrodia camphorata raw material, most
Big degree obtains the active ingredient of Antrodia camphorata, and utilization rate is high.Antrodia camphorata lozenge of the present invention can effectively suppress the stomach and intestine of alcohol
Absorb, strengthen the concentration of alcohol in first pass effect of the ethanol in intestines and stomach, reduction blood, while strengthening Activity of hepatocytes.Antrodia camphorata
Active component is mutually coordinated with Cys, promotes human body to the metabolism of alcohol, with obvious dispelling effects of alcohol, simultaneously
There is certain protective effect to liver.In addition it is easy to carry by the Sobering-up buccal tablet obtained by science flaking method, eat letter
Single, process stabilizing is adapted to large-scale production.Major ingredient used is prepared in the present invention to extract for the edible Antrodia camphorata of medicine-food two-purpose
Thing, can long-term taking, there is good protection and repair to damaged liver.
Brief description of the drawings
Fig. 1 is experimental animal blood alcohol concentration change curve in invention experimental example 5.
Embodiment
To make the objects, technical solutions and advantages of the present invention clearer, clear and definite, come further to solve with reference to embodiments
The present invention is released, but embodiment is not limited in any form to the present invention.
The present invention is relieved the effect of alcohol Antrodia camphorata lozenge, and meter includes by weight：600-800 parts of Antrodia camphorata extract, the Guang ammonia of L- half
Sour 100-200 parts, 250-400 parts of filler, 50-100 parts of wetting agent, 1-20 parts of magnesium stearate.
Wherein, Antrodia camphorata extract includes Antrodia camphorata water extract and/or Antrodia camphorata alcohol extracting thing, preferably its mixture.
The Sobering-up buccal tablet is using Antrodia camphorata extract and Cys as primary raw material, mutually coordinated raising sober-up function.
A variety of triterpenes active materials are rich in lozenge of the present invention, can be suppressed using one side with Cys collocation
The gastrointestinal absorption of alcohol, strengthens the concentration of alcohol in first pass effect of the ethanol in intestines and stomach, reduction blood；On the other hand it can strengthen
Activity of hepatocytes.Furthermore, the lozenge has effects that cell oxidation of acetaldehyde damage can be reduced, by Cys to acetaldehyde
Scavenging action, effectively promotes metabolism of the alcohol in human body, and enhancing human body alleviates various bad diseases to the tolerance of alcohol
Shape, mitigates liver detoxification burden, certain protective effect is played to liver and kidney, can prevent fatty liver, alcohol well
Liver.
Hereinafter, the present invention is explained further with experimental data in conjunction with specific embodiments.
Embodiment 1
The Antrodia camphorata fructification that linden cultivation of learning from else's experience is obtained, is cleaned, chopping.
A. the preparation of Antrodia camphorata water extract
Step A11：The Antrodia camphorata raw material handled well is placed in container, the water of 10 times of Antrodia camphorata raw material volumes is added,
Extracted 60 minutes under the conditions of 80 DEG C, filtering takes filtrate；
Step A12：Repeat step A11 twice；Merge the filtrate of three gained, obtain Antrodia camphorata aqueous extract；
Step A13：Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 80 DEG C, then through 120 DEG C of microwave vacuums
It dry, pulverize, obtain powdered Antrodia camphorata water extract.
B. the preparation of Antrodia camphorata alcohol extracting thing
Step B11：The Antrodia camphorata raw material of water extraction of learning from else's experience is placed in container, adds the absolute ethyl alcohol of 8 times of its volumes,
Flowed back 1 hour under the conditions of 90 DEG C, filtrate is collected in filtering；
Step B12：Repeat step B11 tri- times, merges gained filtrate；Obtain Antrodia camphorata alcohol extract；
Step B13：Ethanol volatilization in Antrodia camphorata alcohol extract is clean, then through micro-wave vacuum, crush, cross 150
Mesh sieve, obtains powdered Antrodia camphorata alcohol extracting thing.
C. the preparation of lozenge
Obtained alcohol extracting thing in obtained Antrodia camphorata water extract in step A and step B is powderedly well mixed
Antrodia camphorata extract.
Raw material is chosen by weight, and 600 parts of Antrodia camphorata extracts, 200 portions of Cys, 300 portions of mannitol are mixed
Uniformly, compound is made.Softwood processed after 80 parts of absolute ethyl alcohol wetting compounds is added, crosses after 18 mesh sieves and pelletizes, make pellet and put
50 DEG C of temperature are dried 60 minutes in baking oven.10 parts of magnesium stearates are added into dried particle to be well mixed, and cross 18 mesh sieves
Whole grain, it is then tabletted under 5 kilograms of pressure, the Antrodia camphorata lozenge that relieves the effect of alcohol is made.
Embodiment 2
The Cinnamomum kanahirai hay camphorata mycelium that liquid deep layer fermenting method of learning from else's experience is obtained, is cleaned, and is crushed.
A. the preparation of Antrodia camphorata water extract
Step A21：The Antrodia camphorata raw material handled well is placed in container, the water of 10 times of Antrodia camphorata raw material volumes is added,
Extracted 60 minutes under the conditions of 85 DEG C, filtering takes filtrate；
Step A22：Repeat step A11 twice；Merge the filtrate of three gained, obtain Antrodia camphorata aqueous extract；
Step A23：Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 80 DEG C, then through 120 DEG C of microwave vacuums
It dry, pulverize, obtain powdered Antrodia camphorata water extract.
B. the preparation of Antrodia camphorata alcohol extracting thing
Step B21：The Antrodia camphorata raw material of water extraction of learning from else's experience is placed in container, adds the absolute ethyl alcohol of 8 times of its volumes,
Flowed back 1 hour under the conditions of 90 DEG C, filtrate is collected in filtering；
Step B22：Repeat step B11 tri- times, merges gained filtrate；Obtain Antrodia camphorata alcohol extract；
Step B23：Ethanol volatilization in Antrodia camphorata alcohol extract is clean, then through micro-wave vacuum, crush, cross 80 mesh
Sieve, obtains powdered Antrodia camphorata alcohol extracting thing.
C. the preparation of lozenge
Obtained alcohol extracting thing in obtained Antrodia camphorata water extract in step A and step B is powderedly well mixed
Antrodia camphorata extract.
Raw material is chosen by weight, and 650 parts of Antrodia camphorata extracts, 150 parts of Cys, 300 parts of lactose are mixed equal
It is even, compound is made.Softwood processed after 80 parts of absolute ethyl alcohol wetting compounds is added, crosses after 18 mesh sieves and pelletizes, make pellet and be placed in
55 DEG C of temperature are dried 60 minutes in baking oven.15 parts of magnesium stearates are added into dried particle to be well mixed, and cross 18 mesh sieves whole
Grain, it is then tabletted under 5 kilograms of pressure, the Antrodia camphorata lozenge that relieves the effect of alcohol is made.
Embodiment 3
A. the preparation of Antrodia camphorata water extract
Step A31：The Antrodia camphorata raw material handled well is placed in container, the water of 10 times of Antrodia camphorata raw material volumes is added,
Extracted 60 minutes under the conditions of 80 DEG C, filtering takes filtrate；
Step A32：Repeat step A11 twice；Merge the filtrate of three gained, obtain Antrodia camphorata aqueous extract；
Step A33：Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 80 DEG C, then through 120 DEG C of microwave vacuums
It dry, pulverize, obtain powdered Antrodia camphorata water extract.
B. the preparation of Antrodia camphorata alcohol extracting thing
Step B31：The Antrodia camphorata raw material of water extraction of learning from else's experience is placed in container, adds the absolute ethyl alcohol of 8 times of its volumes,
Flowed back 1 hour under the conditions of 90 DEG C, filtrate is collected in filtering；
Step B32：Repeat step B11 tri- times, merges gained filtrate；Obtain Antrodia camphorata alcohol extract；
Step B33：Ethanol volatilization in Antrodia camphorata alcohol extract is clean, then through micro-wave vacuum, crush, cross 100
Mesh sieve, obtains powdered Antrodia camphorata alcohol extracting thing.
C. the preparation of lozenge
Obtained alcohol extracting thing in obtained Antrodia camphorata water extract in step A and step B is powderedly well mixed
Antrodia camphorata extract.
Raw material is chosen by weight, and 700 parts of Antrodia camphorata extracts, 100 parts of Cys, 300 parts of microcrystalline celluloses are mixed
Close uniform, compound is made.Softwood processed after 80 parts of absolute ethyl alcohol wetting compounds is added, crosses after 18 mesh sieves and pelletizes, made pellet
50 DEG C of temperature in baking oven are placed in dry 60 minutes.10 parts of magnesium stearates are added into dried particle to be well mixed, and cross 18 mesh
Whole grain is sieved, it is then tabletted under 5 kilograms of pressure, the Antrodia camphorata lozenge that relieves the effect of alcohol is made.
Embodiment 4
A. the preparation of Antrodia camphorata water extract
Step A41：The Antrodia camphorata raw material handled well is placed in container, the water of 10 times of Antrodia camphorata raw material volumes is added,
Extracted 60 minutes under the conditions of 80 DEG C, filtering takes filtrate；
Step A42：Repeat step A11 twice；Merge the filtrate of three gained, obtain Antrodia camphorata aqueous extract；
Step A43：Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 80 DEG C, then through 120 DEG C of microwave vacuums
It dry, pulverize, obtain powdered Antrodia camphorata water extract.
B. the preparation of Antrodia camphorata alcohol extracting thing
Step B41：The Antrodia camphorata raw material of water extraction of learning from else's experience is placed in container, adds the absolute ethyl alcohol of 8 times of its volumes,
Flowed back 1 hour under the conditions of 90 DEG C, filtrate is collected in filtering；
Step B42：Repeat step B11 tri- times, merges gained filtrate；Obtain Antrodia camphorata alcohol extract；
Step B43：Ethanol volatilization in Antrodia camphorata alcohol extract is clean, then through micro-wave vacuum, crush, cross 150
Mesh sieve, obtains powdered Antrodia camphorata alcohol extracting thing.
C. the preparation of lozenge
Obtained alcohol extracting thing in obtained Antrodia camphorata water extract in step A and step B is powderedly well mixed
Antrodia camphorata extract.
Raw material is chosen by weight, and 600 parts of Antrodia camphorata extracts, 200 portions of Cys, 350 portions of Icing Sugar are mixed equal
It is even, compound is made.Softwood processed after 80 parts of absolute ethyl alcohol wetting compounds is added, crosses after 18 mesh sieves and pelletizes, make pellet and be placed in
50 DEG C of temperature are dried 60 minutes in baking oven.10 parts of magnesium stearates are added into dried particle to be well mixed, and cross 18 mesh sieves whole
Grain, it is then tabletted under 5 kilograms of pressure, the Antrodia camphorata lozenge that relieves the effect of alcohol is made.
To further illustrate the sober-up function for the Antrodia camphorata lozenge that relieves the effect of alcohol, with the obtained Cinnamomum kanahirai hay that relieves the effect of alcohol in the embodiment of the present invention 1
Exemplified by sesame lozenge, tested using healthy rat, analyze the effect of the Sobering-up buccal tablet.
Effect of the embodiment 5 to rat blood alcohol concentration
5.1 experiment material
5.1.1 tested material：Relieve the effect of alcohol Antrodia camphorata lozenge obtained by the embodiment of the present invention 1.The human body recommended amounts of tested material are every
Day 5g/ people (body weight is based on 60 kilograms), equivalent to 0.083g/Kg.d.w.
5.1.2 dose design：If blank control group and basic, normal, high four groups, wherein basic, normal, high three dosage groups are given
Pharmaceutical quantities are respectively 0.083g/Kg.d.w, 0.417g/Kg.d.w, 0.833g/Kg.d.w, equivalent to human body recommended amounts 1,5,
10 times；Blank control group is physiological saline.
5.1.3 experimental animal：The healthy rat that Guangdong Province's Experimental Animal Center is provided, 150~200g of body weight.
5.2 experimental method
5.2.1 40 Rat Fasts 5~10 hours, be only divided into four groups by every group 10, respectively as blank control group and
Basic, normal, high dosage group.
5.2.2 physiological saline gavage blank control group rat is used；With the ox of same volume physiological saline solution matched doses
Antrodia Sobering-up buccal tablet (0.083g/Kg.d.w, 0.417g/Kg.d.w, 0.833g/Kg.d.w) distinguishes the basic, normal, high dosage of gavage afterwards
Group rat.
5.2.3 gavage gives 3.000g/Kg.d.w alcohol after 1 hour to every rat.Alcohol need to be carried out dilute with distilled water
Reused after releasing.
5.2.4 0.5h, 1h, 1.5h, 2h, 4h, 6h, 8h, 10h take blood from rat-tail respectively after alcohol gavage.
5.2.5 to institute's blood sampling Immediate management, remove after protein with gas chromatography measure blood alcohol concentration.Measure
The situation of change of rat blood alcohol concentration is as shown in Figure 1.
5.3 experimental result
From Fig. 1 test results, measured in different time sections and show that blank control group rat blood alcohol is dense
Degree is higher than dosage group, and as dosage increase blood alcohol concentration is substantially reduced.Dosage group and blank control group rat blood
Alcohol concentration is reduced as time went on and gradually, but blood alcohol concentration was reduced with action time in dosage group rat
Speed is faster.As can be seen that Antrodia camphorata Sobering-up buccal tablet of the present invention is such as taken before drinking can effectively reduce the suction to alcohol
Receive, dosis tolerata of the increase human body to ethanol.After drinking, Antrodia camphorata Sobering-up buccal tablet can be obviously promoted alcohol metabolism, quickly reduce blood
Liquid alcohol concentration.
Experimental example 6 resists the influence of liquor-saturated effect to rat
6.1 experiment material
6.1.1 tested material：Relieve the effect of alcohol Antrodia camphorata lozenge obtained by the embodiment of the present invention 1.The human body recommended amounts of tested material are every
Day 5g/ people (body weight is based on 60 kilograms), equivalent to 0.083g/Kg.d.w.
6.1.2 dose design：If blank control group and experimental group, experimental group dosage is 0.417g/Kg.d.w (equivalent to people
5 times of body recommended dose).
6.1.3 experimental animal：The healthy rat that Guangdong Province's Experimental Animal Center is provided, 150~200g of body weight.
6.2 experimental method
6.2.1 rat 40 is taken, 5~10h of fasting is randomly divided into control group and experimental group, every group each 20.
6.2.2 physiological saline gavage blank control group rat is used, according to dosage design same volume physiological saline solution sheet
Invention Sobering-up buccal tablet (0.417g/Kg.d.w) gavage experimental group rat afterwards.
6.2.3 alcohol is given by 12.000g/Kg.d.w after gavage 30min.Alcohol need to be carried out dilute with distilled water when using
Release.
6.2.4 using righting reflex loss as drunk index, the drunk time is the length of one's sleep, calculates drunk tolerance time (certainly
Alcohol gavage to righting reflex loss time) and it is drunk hold time (self-righting areflexia to recover time), data
One-way analysis of variance processing, experimental result such as table 1 below are carried out using SPSS softwares.
6.3 experimental result
The present invention of table 1 resists the influence of liquor-saturated effect to rat
From table 1, the drunk tolerance time for having taken the experimental group rat of the Antrodia camphorata lozenge of the invention that relieves the effect of alcohol is substantially long
In control group, and drunk hold time substantially is shortened compared with control group, and two groups of data, which are compared, more significant difference (P ＜
0.05).Therefore, the present invention relieves the effect of alcohol Antrodia camphorata lozenge available for quickly relieving the effect of alcohol, and promotes human body tachymetabolism discharge ethanol, reduces liquor-saturated
The wine time, alleviate drunk symptom.
The antialcoholism action of experimental example 7 is tested
7.1 experiment material
7.1.1 tested material：Lozenge (embodiment 1) of the present invention.The human body recommended amounts of tested material are that daily 5g/ people (press by body weight
60 kilograms of meters), equivalent to 0.083g/Kg.d.w.
7.1.2 dose design：If blank control and experimental group, experimental group dosage is 0.417g/Kg.d.w equivalent to human body
5 times of recommended amounts.
7.1.3 experimental animal：The healthy rat that Guangdong Province's Experimental Animal Center is provided, 150~200g of body weight.
7.2 experimental method
7.2.1 rat 40 is taken, 5~10h of fasting is randomly divided into control group and experimental group, every group each 20.
7.2.2 gavage gives 12.000g/Kg.d.w alcohol respectively, and alcohol need to be diluted with distilled water when using.
7.2.3 physiological saline feeding blank control group is used after alcohol gavage immediately, same volume physiology is used according to dosage design
Salt solution dissolves Sobering-up buccal tablet (0.417g/Kg.d.w) of the present invention feeding experimental group afterwards.
7.2.4 using righting reflex loss as drunk index, the drunk time is the length of one's sleep, calculates drunk tolerance time (certainly
Alcohol gavage to righting reflex loss time) and it is drunk hold time (self-righting areflexia to recovery time), data are adopted
One-way analysis of variance processing is carried out with SPSS softwares, 2 are the results are shown in Table.
7.3 experimental result
The rat of table 2 resists the influence of liquor-saturated effect
* compared with control group, P ＜ 0.05
From table 2, the drunk tolerance time of experimental group rat is suitable with control group, and experimental group is drunk to hold time with compareing
Group is compared to substantially shortening, and have significant difference (P ＜ 0.05).Illustrating to take the present invention Antrodia camphorata lozenge that relieves the effect of alcohol has trivial solution
Wine effect, substantially reduces drunk hold time.
In summary, the present invention relieve the effect of alcohol Antrodia camphorata lozenge to people because drink it is drunk after caused by drunk symptom with very bright
Aobvious mitigation even elimination is acted on, and the time of relieving the effect of alcohol is short, has no adverse reaction.The Sobering-up buccal tablet is such as used before drinking, Ke Yiyou
Effect reduces human body to the intake of alcohol, greatly improves the dosis tolerata to ethanol.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (5)
- The Antrodia camphorata lozenge 1. one kind is relieved the effect of alcohol, it is characterised in that meter includes by weight：600-800 parts of Antrodia camphorata extract, L- 100-200 parts of cysteine, 250-400 parts of filler, 50-100 parts of wetting agent, 1-20 parts of magnesium stearate；The Antrodia camphorata is carried Take thing and the mutually coordinated raising sober-up function of the Cys；The Antrodia camphorata extract is Antrodia camphorata water extract and the mixture of Antrodia camphorata alcohol extracting thing；The filler is at least one of mannitol, microcrystalline cellulose, lactose, starch and Icing Sugar；The wetting agent is absolute ethyl alcohol.
- 2. the preparation method of Antrodia camphorata Sobering-up buccal tablet as claimed in claim 1, it is characterised in that comprise the following steps：After Antrodia camphorata extract, Cys and filler are well mixed, wetting agent softwood is added, 18 mesh sieves are pelletized, Make pellet and dried 30-60 minutes at a temperature of 50-60 DEG C, magnesium stearate is added into dried particle and is well mixed, 18 It is tabletted under 3-10 kilograms of pressure after mesh sieve whole grain, obtain Antrodia camphorata lozenge.
- 3. the preparation method of Antrodia camphorata Sobering-up buccal tablet as claimed in claim 2, it is characterised in that the Antrodia camphorata extract bag Include Antrodia camphorata water-phase extract；The preparation process of the Antrodia camphorata water-phase extract comprises the following steps：Step A1：The water of 5-15 times of its volume is added in Antrodia camphorata raw material, is extracted 30-60 minutes at 80-95 DEG C, mistake Filter, takes filtrate；Step A2：Repeat step A1 is at least twice；Merge gained filtrate, obtain Antrodia camphorata aqueous extract；Step A3：The Antrodia camphorata aqueous extract is concentrated in vacuo into paste under the conditions of 60-80 DEG C, then at 100-120 DEG C Lower use micro-wave vacuum, is crushed；Or, the Antrodia camphorata aqueous extract is concentrated in vacuo into concentrate at 60-80 DEG C, Spraying drying powder-forming at 100-120 DEG C；Step A4：Powder obtained by step A3 is crossed into 80-200 mesh sieves, Antrodia camphorata water-phase extract is obtained.
- 4. the preparation method of Antrodia camphorata Sobering-up buccal tablet according to claim 3, it is characterised in that the Antrodia camphorata extract Also include Antrodia camphorata alcohol extracting thing；The preparation process of the Antrodia camphorata alcohol extracting thing comprises the following steps：Step B1：Antrodia camphorata raw material after aqueous extraction of learning from else's experience, adds the absolute ethyl alcohol of 4-10 times of its volume, in 80-90 Carried out at DEG C 1-1.5 hour of backflow, filtrate is collected in filtering；Step B2：Repeat step B1 is at least one times；Filtrate obtained by merging, obtains Antrodia camphorata alcohol extract；Step B3：Volatilization removes the ethanol in the Antrodia camphorata alcohol extract, and micro-wave vacuum is crushed, and crosses 80-200 mesh sieves, Obtain powdered Antrodia camphorata ethanol extract.
- 5. the Antrodia camphorata lozenge according to claim 1 that relieves the effect of alcohol, it is characterised in that the Antrodia camphorata raw material is solid state rheology Method, solution fermentation or Antrodia camphorata fructification obtained by linden cultivation or mycelium.
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| CN104857060A (en) * | 2015-05-13 | 2015-08-26 | 柳州市耕青科技有限公司 | Traditional Chinese medicine prescription for relieving drunken symptom |
| CN104957307B (en) * | 2015-07-21 | 2018-10-09 | 芝圣（天津）生物科技有限公司 | Antrodia camphorata extract compound tea |
| CN104957308B (en) * | 2015-07-21 | 2018-10-09 | 三生源生物科技（天津）有限公司 | A kind of Antrodia camphorata tea |
| CN105124585B (en) * | 2015-09-18 | 2018-05-11 | 福建农林大学 | A kind of production method of Antrodia camphorata Job's tears instant food |
| CN108378255A (en) * | 2017-12-30 | 2018-08-10 | 佛山科学技术学院 | A kind of Antrodia camphorata health drink and preparation method thereof |
| CN108114267A (en) * | 2017-12-30 | 2018-06-05 | 佛山科学技术学院 | A kind of Antrodia camphorata oral liquor for sobering from wine and preparation method thereof |
| CN108244242A (en) * | 2017-12-30 | 2018-07-06 | 佛山科学技术学院 | A kind of Antialcoholic sour milk and preparation method thereof |
| TWI783217B (en) * | 2020-03-18 | 2022-11-11 | 綠茵生技股份有限公司 | Uses of Antrodia Cinnamomea for Hangover and/or Increase Alcohol Metabolism |
| CN114191537A (en) * | 2021-10-28 | 2022-03-18 | 福建省中医药科学院 | Health product for relieving alcoholism and preparation method thereof |
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