CN104011206B - 新型抗人ctgf抗体 - Google Patents

新型抗人ctgf抗体 Download PDF

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Publication number
CN104011206B
CN104011206B CN201280063995.5A CN201280063995A CN104011206B CN 104011206 B CN104011206 B CN 104011206B CN 201280063995 A CN201280063995 A CN 201280063995A CN 104011206 B CN104011206 B CN 104011206B
Authority
CN
China
Prior art keywords
antibody
human ctgf
human
chain variable
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280063995.5A
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English (en)
Chinese (zh)
Other versions
CN104011206A (zh
Inventor
岩崎正司
守屋隆
守屋隆一
吉野正康
高仓浩二
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CN104011206A publication Critical patent/CN104011206A/zh
Application granted granted Critical
Publication of CN104011206B publication Critical patent/CN104011206B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201280063995.5A 2011-12-22 2012-12-21 新型抗人ctgf抗体 Expired - Fee Related CN104011206B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-281811 2011-12-22
JP2011281811 2011-12-22
PCT/JP2012/083206 WO2013094723A1 (ja) 2011-12-22 2012-12-21 新規抗ヒトｃｔｇｆ抗体

Publications (2)

Publication Number Publication Date
CN104011206A CN104011206A (zh) 2014-08-27
CN104011206B true CN104011206B (zh) 2017-03-08

Family

ID=48668601

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280063995.5A Expired - Fee Related CN104011206B (zh) 2011-12-22 2012-12-21 新型抗人ctgf抗体

Country Status (16)

Country Link
US (1) US9587015B2 (enExample)
EP (1) EP2796550B1 (enExample)
JP (1) JP6040943B2 (enExample)
KR (1) KR20140107507A (enExample)
CN (1) CN104011206B (enExample)
AR (1) AR089425A1 (enExample)
BR (1) BR112014015405A2 (enExample)
CA (1) CA2859627A1 (enExample)
EA (1) EA029290B1 (enExample)
ES (1) ES2665851T3 (enExample)
IN (1) IN2014CN04615A (enExample)
MX (1) MX345019B (enExample)
PL (1) PL2796550T3 (enExample)
PT (1) PT2796550T (enExample)
TW (1) TW201333034A (enExample)
WO (1) WO2013094723A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109824777A (zh) * 2019-03-15 2019-05-31 辽宁何氏医学院 一种具有抑制玻璃体视网膜纤维化病变作用的单克隆抗体及其制备方法和应用
US20200369759A1 (en) 2019-05-23 2020-11-26 Fibrogen, Inc. Methods of treatment of muscular dystrophies
MY208454A (en) * 2019-06-04 2025-05-09 Shanghai hengrui pharmaceutical co ltd Anti-connective tissue growth factor antibody and application thereof
AU2021390125A1 (en) * 2020-12-03 2023-06-22 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising anti-connective tissue growth factor antibody
US20250163158A1 (en) 2022-06-07 2025-05-22 Astellas Pharma Inc. Pharmaceutical composition containing anti-integrin alpha11 antibody for treatment or prevention of aging-related diseases
WO2024095964A1 (ja) 2022-10-31 2024-05-10 アステラス製薬株式会社 Ｔｏｌｌ様受容体７／８デュアルアゴニスト化合物を含む抗体薬物複合体
TW202502816A (zh) * 2023-03-10 2025-01-16 大陸商上海濟煜醫藥科技有限公司 一種靶向ｃｔｇｆ的抗體或其抗原結合片段及其應用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532082A (ja) * 1998-12-14 2002-10-02 ユニバーシティー オブ マイアミ 結合組織成長因子（ｃｔｇｆ）断片とそれを用いた方法および使用
JP2004524841A (ja) * 2001-02-16 2004-08-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 真核生物細胞を改変する方法
CN1829740A (zh) * 2003-06-04 2006-09-06 菲布罗根公司 结缔组织生长因子抗体
WO2007066823A1 (ja) * 2005-12-07 2007-06-14 Nosan Corporation 結合組織増殖因子に対する抗体又はそれを含む組成物
WO2010053751A1 (en) * 2008-10-29 2010-05-14 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human il-4 receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8808645U1 (de) 1988-07-06 1988-08-25 Hofer, Daniel, 7730 Villingen-Schwenningen Anzeigeeinrichtung für Feuerlöscher
KR100337069B1 (ko) 1993-03-11 2002-10-11 사이단호진가가쿠오요비겟세이리요호오겐큐쇼 항-hiv모노클로날항체
WO1999033878A1 (en) * 1997-12-25 1999-07-08 Japan Tobacco Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
JP4537507B2 (ja) 1997-12-25 2010-09-01 アムジェン インコーポレイテッド 結合組織増殖因子に対するモノクローナル抗体及びその医薬用途
US7115390B1 (en) 1998-12-14 2006-10-03 Fibrogen, Inc. Connective tissue growth factor fragments and methods and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532082A (ja) * 1998-12-14 2002-10-02 ユニバーシティー オブ マイアミ 結合組織成長因子（ｃｔｇｆ）断片とそれを用いた方法および使用
JP2004524841A (ja) * 2001-02-16 2004-08-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 真核生物細胞を改変する方法
CN1829740A (zh) * 2003-06-04 2006-09-06 菲布罗根公司 结缔组织生长因子抗体
WO2007066823A1 (ja) * 2005-12-07 2007-06-14 Nosan Corporation 結合組織増殖因子に対する抗体又はそれを含む組成物
WO2010053751A1 (en) * 2008-10-29 2010-05-14 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human il-4 receptor

Also Published As

Publication number Publication date
ES2665851T3 (es) 2018-04-27
MX345019B (es) 2017-01-11
EP2796550A4 (en) 2015-08-19
EA201491240A1 (ru) 2014-11-28
EP2796550B1 (en) 2018-02-28
PT2796550T (pt) 2018-04-18
US20140343258A1 (en) 2014-11-20
CN104011206A (zh) 2014-08-27
CA2859627A1 (en) 2013-06-27
WO2013094723A1 (ja) 2013-06-27
EP2796550A1 (en) 2014-10-29
US9587015B2 (en) 2017-03-07
TW201333034A (zh) 2013-08-16
KR20140107507A (ko) 2014-09-04
EA029290B1 (ru) 2018-03-30
IN2014CN04615A (enExample) 2015-09-18
JP6040943B2 (ja) 2016-12-07
AR089425A1 (es) 2014-08-20
JPWO2013094723A1 (ja) 2015-04-27
PL2796550T3 (pl) 2018-08-31
BR112014015405A2 (pt) 2017-06-13
MX2014007681A (es) 2014-11-25

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Granted publication date: 20170308

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