CN104010652A - 超浓缩的速效胰岛素类似物制剂 - Google Patents

超浓缩的速效胰岛素类似物制剂 Download PDF

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Publication number
CN104010652A
CN104010652A CN201280064561.7A CN201280064561A CN104010652A CN 104010652 A CN104010652 A CN 104010652A CN 201280064561 A CN201280064561 A CN 201280064561A CN 104010652 A CN104010652 A CN 104010652A
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CN
China
Prior art keywords
insulin
substitution
sequence
chain
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280064561.7A
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English (en)
Chinese (zh)
Inventor
M.魏斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of CN104010652A publication Critical patent/CN104010652A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280064561.7A 2011-10-27 2012-10-29 超浓缩的速效胰岛素类似物制剂 Pending CN104010652A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552246P 2011-10-27 2011-10-27
US61/552246 2011-10-27
PCT/US2012/062423 WO2013063572A1 (en) 2011-10-27 2012-10-29 Ultra-concentrated rapid-acting insulin analogue formulations

Publications (1)

Publication Number Publication Date
CN104010652A true CN104010652A (zh) 2014-08-27

Family

ID=48168643

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280064561.7A Pending CN104010652A (zh) 2011-10-27 2012-10-29 超浓缩的速效胰岛素类似物制剂

Country Status (10)

Country Link
US (1) US9908925B2 (OSRAM)
EP (1) EP2771026A4 (OSRAM)
JP (1) JP2014533241A (OSRAM)
KR (1) KR20150021011A (OSRAM)
CN (1) CN104010652A (OSRAM)
AU (1) AU2012328407A1 (OSRAM)
BR (1) BR112014010139A2 (OSRAM)
IN (1) IN2014CN03888A (OSRAM)
SG (1) SG11201401835VA (OSRAM)
WO (1) WO2013063572A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430493A (zh) * 2015-12-23 2018-08-21 卡斯西部储备大学 超稳胰岛素类似物在聚合物熔体中的包囊

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102163936B1 (ko) * 2012-11-05 2020-10-13 케이스 웨스턴 리저브 유니버시티 장기-활성 싱글-체인 인슐린 유사체
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2016064606A1 (en) * 2014-10-20 2016-04-28 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
AU2015349890B2 (en) * 2014-11-21 2018-08-30 Merck Sharp & Dohme Llc Insulin receptor partial agonists
WO2016105545A2 (en) * 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
EP3341403B1 (en) 2015-08-25 2022-01-05 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
US20180244743A1 (en) 2015-08-25 2018-08-30 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
JP2018531901A (ja) 2015-08-25 2018-11-01 ノヴォ ノルディスク アー／エス 新規インスリン誘導体及びその医学的使用
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
CA3122636A1 (en) * 2018-12-11 2020-06-18 Sanofi Insulin analogs having reduced insulin receptor binding affinity
MY208364A (en) 2019-12-11 2025-05-01 Novo Nordisk As Novel insulin analogues and uses thereof
WO2024194897A1 (en) * 2023-03-22 2024-09-26 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) A glycation resistant insulin polypeptide and a method of preparing the same thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US20100099601A1 (en) * 2006-10-04 2010-04-22 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20110166064A1 (en) * 2008-07-31 2011-07-07 Case Western Reserve University Halogen-stabilized insulin
US20110257091A1 (en) * 2008-12-19 2011-10-20 Dimarchi Richard D Insulin analogs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU616205B2 (en) 1988-07-20 1991-10-24 Novo Nordisk A/S Human insulin analogs and preparations containing them
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
WO2003048195A2 (en) 2001-12-02 2003-06-12 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
KR20050106115A (ko) * 2003-03-11 2005-11-08 노보 노르디스크 에이/에스 산-안정화 인슐린을 포함하는 약학적 제제
SE0401942D0 (sv) 2004-07-28 2004-07-28 Lipopeptide Ab New antimicrobial peptide complexes
JP2008510692A (ja) 2004-08-20 2008-04-10 ノボ ノルディスク アクティーゼルスカブ 薬学的に活性なインスリン受容体調節分子
KR101656107B1 (ko) * 2007-11-20 2016-09-08 암브룩스, 인코포레이티드 변형된 인슐린 폴리펩티드 및 이의 용도
MX2011001181A (es) * 2008-07-31 2011-04-05 Univ Case Western Reserve Insulina estabilizada con halogeno.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US20100099601A1 (en) * 2006-10-04 2010-04-22 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20110166064A1 (en) * 2008-07-31 2011-07-07 Case Western Reserve University Halogen-stabilized insulin
US20110257091A1 (en) * 2008-12-19 2011-10-20 Dimarchi Richard D Insulin analogs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108430493A (zh) * 2015-12-23 2018-08-21 卡斯西部储备大学 超稳胰岛素类似物在聚合物熔体中的包囊

Also Published As

Publication number Publication date
WO2013063572A1 (en) 2013-05-02
US9908925B2 (en) 2018-03-06
EP2771026A1 (en) 2014-09-03
BR112014010139A2 (pt) 2017-04-25
KR20150021011A (ko) 2015-02-27
NZ624493A (en) 2016-02-26
JP2014533241A (ja) 2014-12-11
EP2771026A4 (en) 2015-08-05
IN2014CN03888A (OSRAM) 2015-10-16
SG11201401835VA (en) 2014-09-26
AU2012328407A1 (en) 2014-05-22
US20140323398A1 (en) 2014-10-30

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Legal Events

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140827