CN104004039A - 6,11-桥联的联芳大环内酯类 - Google Patents

6,11-桥联的联芳大环内酯类 Download PDF

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Publication number
CN104004039A
CN104004039A CN201410219293.2A CN201410219293A CN104004039A CN 104004039 A CN104004039 A CN 104004039A CN 201410219293 A CN201410219293 A CN 201410219293A CN 104004039 A CN104004039 A CN 104004039A
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China
Prior art keywords
group
hydrogen
unsubstituted
prodrug
independently
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CN201410219293.2A
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English (en)
Chinese (zh)
Inventor
金寅锤
刘同柱
龙江
王国强
邱遥龄
金希珍
王燕春
潘心理
柯日新
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Enanta Pharmaceuticals Inc
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Enanta Pharmaceuticals Inc
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Publication of CN104004039A publication Critical patent/CN104004039A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201410219293.2A 2007-09-17 2008-09-17 6,11-桥联的联芳大环内酯类 Pending CN104004039A (zh)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US97301707P 2007-09-17 2007-09-17
US60/973,017 2007-09-17
US97320107P 2007-09-18 2007-09-18
US60/973,201 2007-09-18
US5186208P 2008-05-09 2008-05-09
US5185708P 2008-05-09 2008-05-09
US5187508P 2008-05-09 2008-05-09
US61/051,857 2008-05-09
US61/051,875 2008-05-09
US61/051,862 2008-05-09
US7621308P 2008-06-27 2008-06-27
US7620808P 2008-06-27 2008-06-27
US61/076,208 2008-06-27
US61/076,213 2008-06-27
US9510008P 2008-09-08 2008-09-08
US9511108P 2008-09-08 2008-09-08
US61/095,100 2008-09-08
US61/095,111 2008-09-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880115910.7A Division CN101855219B (zh) 2007-09-17 2008-09-17 6，11-桥联的联芳大环内酯类

Publications (1)

Publication Number Publication Date
CN104004039A true CN104004039A (zh) 2014-08-27

Family

ID=40455143

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410219293.2A Pending CN104004039A (zh) 2007-09-17 2008-09-17 6,11-桥联的联芳大环内酯类
CN200880115910.7A Expired - Fee Related CN101855219B (zh) 2007-09-17 2008-09-17 6，11-桥联的联芳大环内酯类

Family Applications After (1)

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CN200880115910.7A Expired - Fee Related CN101855219B (zh) 2007-09-17 2008-09-17 6，11-桥联的联芳大环内酯类

Country Status (11)

Country Link
US (2) US20090118506A1 (cg-RX-API-DMAC10.html)
EP (1) EP2203435B1 (cg-RX-API-DMAC10.html)
JP (2) JP5642548B2 (cg-RX-API-DMAC10.html)
KR (2) KR20120132577A (cg-RX-API-DMAC10.html)
CN (2) CN104004039A (cg-RX-API-DMAC10.html)
AU (1) AU2008335668C1 (cg-RX-API-DMAC10.html)
CA (1) CA2699733C (cg-RX-API-DMAC10.html)
ES (1) ES2691252T3 (cg-RX-API-DMAC10.html)
MX (1) MX2010002932A (cg-RX-API-DMAC10.html)
NZ (2) NZ584159A (cg-RX-API-DMAC10.html)
WO (2) WO2009075923A2 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010002932A (es) * 2007-09-17 2010-05-27 Enanta Pharm Inc Macrolidos de biarilo con puente en 6, 11.
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US7842813B2 (en) * 2008-05-09 2010-11-30 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine
US8552162B2 (en) * 2008-05-09 2013-10-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
RU2601550C2 (ru) * 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
KR20180084049A (ko) * 2015-11-19 2018-07-24 바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. 제약 화합물의 아민 전구약물

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CN1244532A (zh) * 1998-03-03 2000-02-16 辉瑞产品公司 3,6－缩醛和烯醇醚大环内酯抗生素
CN1351606A (zh) * 1999-05-03 2002-05-29 普利瓦药物工业公司 9－脱氧－9a－氮杂－9a高红霉素A的卤代衍生物
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US20060252712A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US20070082853A1 (en) * 2005-10-12 2007-04-12 Or Yat S 6, 11-bridged tricyclic macrolides

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NZ536403A (en) * 2002-05-13 2008-02-29 Enanta Pharm Inc 6-11 Bicyclic ketolide derivatives
US6764998B1 (en) * 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6753318B1 (en) * 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US7022679B2 (en) * 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
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* Cited by examiner, † Cited by third party
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CN85103264A (zh) * 1984-04-13 1987-01-14 美国辉瑞有限公司 9a-氮杂-9a-高红霉素衍生物
CN1244532A (zh) * 1998-03-03 2000-02-16 辉瑞产品公司 3,6－缩醛和烯醇醚大环内酯抗生素
CN1351606A (zh) * 1999-05-03 2002-05-29 普利瓦药物工业公司 9－脱氧－9a－氮杂－9a高红霉素A的卤代衍生物
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US20060252712A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US20070082853A1 (en) * 2005-10-12 2007-04-12 Or Yat S 6, 11-bridged tricyclic macrolides

Also Published As

Publication number Publication date
KR20120132577A (ko) 2012-12-05
KR20100059990A (ko) 2010-06-04
MX2010002932A (es) 2010-05-27
CN101855219B (zh) 2014-06-25
EP2203435A2 (en) 2010-07-07
KR101223158B1 (ko) 2013-01-17
JP2015017139A (ja) 2015-01-29
EP2203435A4 (en) 2011-03-02
CA2699733A1 (en) 2009-06-18
ES2691252T3 (es) 2018-11-26
CA2699733C (en) 2013-01-22
WO2009075923A3 (en) 2009-09-24
JP5642548B2 (ja) 2014-12-17
AU2008335668B2 (en) 2012-07-26
JP2010539191A (ja) 2010-12-16
NZ600635A (en) 2013-06-28
EP2203435B1 (en) 2018-07-18
WO2009075923A2 (en) 2009-06-18
US20090075915A1 (en) 2009-03-19
WO2009039177A1 (en) 2009-03-26
CN101855219A (zh) 2010-10-06
NZ584159A (en) 2012-08-31
AU2008335668C1 (en) 2013-05-30
AU2008335668A1 (en) 2009-06-18
US20090118506A1 (en) 2009-05-07

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Application publication date: 20140827