CN104000925B - A kind of pharmaceutical composition and application thereof for the treatment of thyromegaly - Google Patents
A kind of pharmaceutical composition and application thereof for the treatment of thyromegaly Download PDFInfo
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- CN104000925B CN104000925B CN201410225888.9A CN201410225888A CN104000925B CN 104000925 B CN104000925 B CN 104000925B CN 201410225888 A CN201410225888 A CN 201410225888A CN 104000925 B CN104000925 B CN 104000925B
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- thyromegaly
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Abstract
The invention discloses a kind of pharmaceutical composition and application thereof for the treatment of thyromegaly, said composition is prepared from by Chinese medicine extract and adjuvant, described Chinese medicine extract is prepared from as follows: take seed of Arillus Longan, pulverize, by 90%-95% alcoholic solution heating and refluxing extraction, extracting solution concentrating under reduced pressure becomes paste, add pure water mixing, with n-hexane extraction, gained extract reclaims normal hexane and lyophilization, obtains Chinese medicine extract.Medicine of the present invention can reduce the thyroid index of thyromegaly patient, improves serum T T
3content, thus treat various thyromegaly.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of Drugs Treatment on Thyroid Disease, particularly relate to a kind of pharmaceutical composition and application thereof for the treatment of thyromegaly.
Background technology
Thyroid is the maximum endocrinal glands of human body, and be close to trachea the 3rd under being positioned at thyroid cartilage, before four cartilaginous rings, be made up of two lateral lobes and isthmus, average weight becomes about 20-25g.Parathyroid hormone 1-34 piece and recurrent laryngeal nerve is had after thyroid.Blood supply has four tremulous pulsies up and down, so thyroid blood is for abundanter, body of gland is subject to sympathetic nerve and the vagus innervates of cervical sympathetic ganglia, and thyroid major function is synthetic thyroid hormone, regulates organism metabolism.The factor of thyromegaly is caused to mainly contain congenital thyroxin synthesis defect, iodine deficiency and high iodine, role of autoimmune factors and environmental pollution.
Thyroid storm usually come fast and violent, possible reveal any symptoms be body temperature more than 39 degree and rapid with beat pulse, feel sick, diarrhoea or hepatomegaly, jaundice, dysphoria, to be all of a tremble, if without suitable rescue, may there is mental disorder, stupor, arrhythmia or heart failure and dead in patient.Because clinical manifestation is very serious, course advancement is also quite quick, if do not have Treatment and diagnosis immediately, mortality rate can up to 90 percent.Therefore, there is above-mentioned symptom once discovery hyperthyroidism disease patient, should at once for patient's ice compress be lowered the temperature, is taken antithyroid drug and send doctor.
Chinese medicine is the same with food is derive from the mineral of the Nature, plant, animal drugs, and do not have toxic and side effects, Chinese medicine does not have Drug resistance, can continue to use until radical curing of disease, so invent a kind of Chinese medicine preparation for improvement thyroid disease by significant.
Summary of the invention
The object of the invention is to by furtheing investigate Chinese crude drug, a kind of medicine of plant-derived treatment thyromegaly is provided.This medicine for active component, can be used for the treatment of thyromegaly disease patient with seed of Arillus Longan extract.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition for the treatment of thyromegaly, be prepared from by Chinese medicine extract and adjuvant, described Chinese medicine extract is prepared from as follows: take seed of Arillus Longan, pulverize, by 90%-95% alcoholic solution heating and refluxing extraction, extracting solution concentrating under reduced pressure becomes paste, add pure water mixing, with n-hexane extraction, gained extract reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
It should be noted that, seed of Arillus Longan of the present invention selects the dry seed of Sapindaceae Euphoria plant Arillus Longan DimocarpuslonganLour..
Preferably, the pharmaceutical composition for the treatment of thyromegaly as mentioned above, the consumption of wherein said alcoholic solution is 8-15 times (v/w) of seed of Arillus Longan quality.
Preferably, the pharmaceutical composition for the treatment of thyromegaly, wherein adopts 80-90 DEG C of heating in water bath alcoholic solution reflux, extract, 1-1.5h as mentioned above, extracts 2-4 time altogether.
Further preferably, the pharmaceutical composition for the treatment of thyromegaly described above is oral formulations, described oral formulations comprises tablet, capsule, granule, with above-mentioned Chinese medicine extract for active component, filler, disintegrating agent and the lubricant conventional using this area, as pharmaceutically acceptable auxiliaries, adopt the preparation of common process direct compression and obtain.
Methylthiouracil can to stop in thyroid tyrosine iodate and be coupled, and suppresses thyroxinic biosynthesis, thyroxine synthesis in body is reduced, by negative feedback, produces a large amount of thyrotropin (TSH), stimulate thyroid hyperplasia.Thus there is the symptom similar to the simple goiter that iodine deficiency causes after giving methylthiouracil in rat, as: rat thyroid index raises, TT
3content declines, and thyroid glands is intensive to be increased, and glandular epithelium high column, in folliculus, colloid obviously reduces.The method that the present invention adopts gavage to give methylthiouracil successfully replicates animal model strumous, and adopting seed of Arillus Longan extract to intervene rat model, the thyroid index that result display gives the rat of seed of Arillus Longan extract of the present invention significantly reduces, serum T T
3content significantly raises, and this imply that to adopt the seed of Arillus Longan extract prepared of extraction and separation process of the present invention can antagonism thyromegaly, especially can treat the thyromegaly that iodine deficiency causes.Therefore, the present invention also provides a kind of pharmaceutical applications, that is: the Chinese medicine extract that prepared by above-mentioned technique treats the application in the medicine of thyromegaly in preparation.
Compared with prior art, the pharmaceutical composition that the present invention relates to has following outstanding advantage: (1) has the biological activity of stronger treatment thyromegaly, and can not produce drug resistance; (2) for treatment thyromegaly disease provides new drug candidate, safe without toxic side effect, short treating period, instant effect, there is very important clinical meaning.
Detailed description of the invention
Be below the preparation embodiment of seed of Arillus Longan extract of the present invention, and further illustrate by animal experiment example the biological activity that seed of Arillus Longan extract has stronger goiter.
Embodiment 1: the preparation of seed of Arillus Longan extract
By seed of Arillus Longan roguing, clean up, pulverized 32 mesh sieves, take seed of Arillus Longan powder 1kg, be placed in extraction element, add 95% alcoholic solution of 10L volume, the heating in water bath reflux, extract, 1.5h of 85 DEG C, extracts 2 times, merge extractive liquid, altogether, concentrating under reduced pressure becomes paste, adds the pure water of 1 times amount, abundant stirring and evenly mixing, add the n-hexane extraction 3 times of 2 times of volumes, combining extraction liquid, reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
Embodiment 2: the preparation of seed of Arillus Longan extract
By seed of Arillus Longan roguing, clean up, pulverized 32 mesh sieves, take seed of Arillus Longan powder 10kg, be placed in extraction element, add 95% alcoholic solution of 80L volume, the heating in water bath reflux, extract, 2h of 85 DEG C, extracts 2 times, merge extractive liquid, altogether, concentrating under reduced pressure becomes paste, adds the pure water of 1.5 times amount, abundant stirring and evenly mixing, add the n-hexane extraction 3 times of 2 times of volumes, combining extraction liquid, reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
Comparative example: the preparation of seed of Arillus Longan extract
By seed of Arillus Longan roguing, clean up, pulverized 32 mesh sieves, take seed of Arillus Longan powder 1kg, be placed in extraction element, add 95% alcoholic solution of 10L volume, the heating in water bath reflux, extract, 1.5h of 85 DEG C, extracts 2 times, merge extractive liquid, altogether, concentrating under reduced pressure becomes paste, adds the pure water of 1 times amount, abundant stirring and evenly mixing, add the petroleum ether extraction 3 times of 2 times of volumes, combining extraction liquid, reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
Embodiment 3 Chinese medicine extract affects experimental study to goiter model rat
Healthy male Wistar rat 40, body weight 18O ~ 200g, is divided into following four groups at random: blank group, model control group, test I group, test II group, often organizes 10 rats.After on-test, according to rat weight, test I group and give above-mentioned comparative example the seed of Arillus Longan extract 50mg/kg/d prepared, test the seed of Arillus Longan extract 50mg/kg/d that II group gives the embodiment of the present invention 1 preparation, blank group and model control group give the pure water of equal volume amounts, four groups of all continuous gavages give corresponding tested material 12 days, 10mL/kg, once a day.Within after administration the 3rd day, except blank group, other two groups of gavages give methylthiouracil 20mg/kg/d, continuous 10 days, cause goiter model.After drug withdrawal, next day gets blood, separation of serum.Put method of exempting from and measure TT
3; Then etherization puts to death rat, gets thyroid and claims weight in wet base, calculates thyroid index.Each group of rat thyroid index and serum T T
3comparision contents is in table 1.
Can be found out by the test statistics result of table 1, compared with blank group, the thyroid index of model control group rat significantly increases, serum T T3 content sharply reduces (P < 0.01), and this illustrates that the method adopting gavage to give methylthiouracil can successfully manufacture animal model strumous.In addition, with model control group or test I group and compare, the thyroid index testing II group of rat reduces, serum T T
3content raises (P < 0.01), this imply that to adopt the seed of Arillus Longan extract prepared of extraction process of the present invention can the thyromegaly that causes of anti-iodine deficiency, thus reaches therapeutic effect.
Table 1 is group rat thyroid index and serum T T respectively
3comparision contents
Compare with blank group,
★p < 0.05,
★ ★p < 0.01; Compare with model control group,
▼p < 0.05,
▼ ▼p < 0.01; Compare with test I group,
■p < 0.05,
■ ■p < 0.01.
Claims (4)
1. treat the pharmaceutical composition of thyromegaly for one kind, be prepared from by Chinese medicine extract and adjuvant, it is characterized in that described Chinese medicine extract is prepared from as follows: take seed of Arillus Longan, pulverize, by 90%-95% alcoholic solution heating and refluxing extraction, extracting solution concentrating under reduced pressure becomes paste, add pure water mixing, with n-hexane extraction, gained extract reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
2. treat the pharmaceutical composition of thyromegaly according to claim 1, it is characterized in that: adopt 80-90 DEG C of heating in water bath alcoholic solution reflux, extract, 1-1.5h, extract 2-4 time altogether.
3. according to claim 1 or 2, treat the pharmaceutical composition of thyromegaly, it is characterized in that: described pharmaceutical composition is oral formulations, and described oral formulations comprises tablet, capsule, granule.
4. the application of Chinese medicine extract in the medicine of preparation treatment thyromegaly, it is characterized in that described Chinese medicine extract is prepared from as follows: take seed of Arillus Longan, pulverize, by 90%-95% alcoholic solution heating and refluxing extraction, extracting solution concentrating under reduced pressure becomes paste, adds pure water mixing, with n-hexane extraction, gained extract reclaims normal hexane and lyophilization, obtains Chinese medicine extract.
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| CN201410225888.9A CN104000925B (en) | 2014-05-27 | 2014-05-27 | A kind of pharmaceutical composition and application thereof for the treatment of thyromegaly |
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| CN201410225888.9A CN104000925B (en) | 2014-05-27 | 2014-05-27 | A kind of pharmaceutical composition and application thereof for the treatment of thyromegaly |
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| CN104000925B true CN104000925B (en) | 2016-03-30 |
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Non-Patent Citations (2)
| Title |
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| 响应面分析法优化龙眼核中多酚物质提取工艺;王淑霞等;《食品科学》;20111231;第32卷(第10期);第35-39页 * |
| 自由基在地方性甲状腺肿发病学上的可能作用;陈祖培等;《中国地方病学杂志》;19941231;第13卷(第4期);第197-199页 * |
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