CN103990174A - Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device - Google Patents
Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device Download PDFInfo
- Publication number
- CN103990174A CN103990174A CN201410240612.8A CN201410240612A CN103990174A CN 103990174 A CN103990174 A CN 103990174A CN 201410240612 A CN201410240612 A CN 201410240612A CN 103990174 A CN103990174 A CN 103990174A
- Authority
- CN
- China
- Prior art keywords
- fiber
- layer
- diffusion layer
- vertical
- fluid aspirating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000007788 liquid Substances 0.000 title abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 154
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 100
- 238000009792 diffusion process Methods 0.000 claims abstract description 42
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 23
- 239000002250 absorbent Substances 0.000 claims abstract description 4
- 230000002745 absorbent Effects 0.000 claims abstract description 4
- 239000012530 fluid Substances 0.000 claims description 62
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 22
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 22
- 241001330002 Bambuseae Species 0.000 claims description 22
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 22
- 239000011425 bamboo Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- -1 polypropylene Polymers 0.000 claims description 16
- 229920000297 Rayon Polymers 0.000 claims description 13
- 238000001467 acupuncture Methods 0.000 claims description 13
- 239000004743 Polypropylene Substances 0.000 claims description 12
- 229920001778 nylon Polymers 0.000 claims description 12
- 229920001155 polypropylene Polymers 0.000 claims description 12
- 229920000742 Cotton Polymers 0.000 claims description 11
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 229920000573 polyethylene Polymers 0.000 claims description 10
- 229920000049 Carbon (fiber) Polymers 0.000 claims description 9
- 239000004917 carbon fiber Substances 0.000 claims description 9
- 238000005213 imbibition Methods 0.000 claims description 9
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 9
- 239000004677 Nylon Substances 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 8
- 229920000433 Lyocell Polymers 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000002002 slurry Substances 0.000 claims description 6
- 229920002101 Chitin Polymers 0.000 claims description 5
- 229920001131 Pulp (paper) Polymers 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 229920004933 Terylene® Polymers 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 239000010902 straw Substances 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002972 Acrylic fiber Polymers 0.000 claims description 2
- 229920002749 Bacterial cellulose Polymers 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 241001597008 Nomeidae Species 0.000 claims description 2
- 230000010933 acylation Effects 0.000 claims description 2
- 238000005917 acylation reaction Methods 0.000 claims description 2
- 239000005016 bacterial cellulose Substances 0.000 claims description 2
- 239000000648 calcium alginate Substances 0.000 claims description 2
- 235000010410 calcium alginate Nutrition 0.000 claims description 2
- 229960002681 calcium alginate Drugs 0.000 claims description 2
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 229920003064 carboxyethyl cellulose Polymers 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 238000010030 laminating Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 96
- 241000894006 Bacteria Species 0.000 abstract description 11
- 108010006035 Metalloproteases Proteins 0.000 abstract description 4
- 102000005741 Metalloproteases Human genes 0.000 abstract description 4
- 230000035876 healing Effects 0.000 abstract description 3
- 230000002757 inflammatory effect Effects 0.000 abstract description 3
- 239000000758 substrate Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 79
- 239000004744 fabric Substances 0.000 description 31
- 241000700159 Rattus Species 0.000 description 22
- 238000002474 experimental method Methods 0.000 description 20
- 206010053615 Thermal burn Diseases 0.000 description 16
- 241000191967 Staphylococcus aureus Species 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 238000005303 weighing Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 239000000975 dye Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000011081 inoculation Methods 0.000 description 7
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000017074 necrotic cell death Effects 0.000 description 6
- 229910052709 silver Inorganic materials 0.000 description 6
- 239000004332 silver Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 5
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 5
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 5
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 5
- 238000000879 optical micrograph Methods 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 description 4
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 4
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 206010056340 Diabetic ulcer Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229960002275 pentobarbital sodium Drugs 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 241000219357 Cactaceae Species 0.000 description 1
- 101100008048 Caenorhabditis elegans cut-4 gene Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical class [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000005230 Leg Ulcer Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000009982 dyeing by method Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 208000012313 wound discharge Diseases 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a powerful liquid absorption and drainage dressing, a preparation method thereof and a liquid absorption and drainage device. The powerful liquid absorption and drainage dressing comprises a vertical absorption layer, a middle layer and an absorptive diffusion layer which are adhered in sequence, wherein the vertical absorption layer is made of hydrophobic fibers and hydrophilic fibers; the content of the hydrophobic fibers is over 30 percent of the total weight of the vertical absorption layer; the middle layer is made of hydrophilic fibers or absorbent paper; the absorptive diffusion layer is made of hydrophilic fibers and hydrophobic fibers which account for below 50 percent of the total weight of the absorptive diffusion layer. The powerful liquid absorption and drainage dressing can be used for vertically guiding moisture, has high hygroscopic property, and can be used for transmitting inflammatory mediator-containing seepage, including carrions, bacteria, substrate metalloprotease, biological films and the like which are adsorbed deep into tissues out to promote healing of wounds.
Description
Technical field
The present invention relates to medical material tech field, be specifically related to a kind of strong fluid aspirating drain dressing and preparation method thereof and imbibition drainage system.
Background technology
In wound organ-tissue tissue from shallow to deep, all have a large amount of sepages, inflammatory mediator, slough, matrix metalloproteinase and biomembrane, these materials and normal cell mix the existence that interweaves, and are the basic reasons that causes bacterial growth, the wound refused to heal.Current dressing is only that the imbibition by water wetted material reaches the object of absorption, locking sepage, cannot reach the object of " slough, deep antibacterial, matrix metalloproteinase, biomembrane and containing the synchronous adsorption removal of the sepage of inflammatory mediator ".
The hygroscopicity of at present main fiber wound dressing is generally between 12-20 gram/100 square centimeters.The grammes per square metre of these dressing is generally between 100-150 gram/m, so its hygroscopicity is limited, is the highlyest no more than 25 grams/100 square centimeters.Therefore in the situation that wound exudate is more, this class dressing is difficult to reply, need to increase the requirement that change of dressing number of times adapts to wound care.Clinically, wish the dressing of hygroscopicity higher (for example, over 30 grams/100 square centimeters).Main is, current wound dressing is as long as there has been imbibition in a region, liquid can be diffused into other regions very soon, such as be diffused into the healthy skin of wound perimeter from wound, this is very undesirable situation, because the healthy skin of periphery can be because being flooded and sustain damage by wound juice for a long time like this.
Current wound dressing is difficult to liquid transfer beyond dressing, can only be by change of dressing after imbibition is saturated.When if wound fluid is a lot, need frequently more change dressings, not only caused patient's use cost to raise, also can cause that patient is uncomfortable, affect wound healing.Meanwhile, existing dressing is to absorb to expand to cause the sepage locking of its absorption to accumulate in dressing and cannot shift due to what emphasize, has restricted its liquid absorption.Cannot provide self-dissolving, enzyme decomposition, phagocyte to engulf the occasion of decomposition for being adsorbed to the slough bulky grain of dressing the inside simultaneously.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of strong fluid aspirating drain dressing, can vertically lead wet, have high-hygroscopicity, can by wherein absorption slough bulky grain resolve into granule, organize deep matrix metalloproteinase, biomembrane, the antibacterial etc. that liquid can be comprised again to absorption pass, and promote the healing of wound.
Another object of the present invention is to provide a kind of preparation method of strong fluid aspirating drain dressing, to obtain a kind of strong fluid aspirating drain dressing with high-hygroscopicity.
For addressing the above problem, the technical solution adopted in the present invention is as follows:
A kind of strong fluid aspirating drain dressing, it comprises vertical absorbed layer, intermediate layer and the absorption diffusion layer of laminating successively, described vertical absorbed layer is that raw material is made by hydrophobic fiber and hydrophilic fibers, and wherein, in the gross weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%; Described intermediate layer is that hydrophilic fibers or absorbent paper are made; Described absorption diffusion layer by hydrophilic fibers and in the gross weight that absorbs diffusion layer the hydrophobic fiber below 50% make.
The wound contact layer of common hydroscopic dressings is difficult to avoid the problem of liquid cross conduction.In the present invention, inventor finds that through research containing a certain proportion of hydrophobic fiber can slow down the horizontal proliferation that even stops liquid.Therefore described vertical absorbed layer adopts hydrophobic fiber and hydrophilic fibers to be composited, it can effectively conduct to rapidly intermediate layer by wound juice, and this conduction is almost vertical, seldom even there is no cross conduction, make most wound exudate be conducted to rapidly intermediate layer, rather than diffuse to periphery; Wherein, in the gross weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%, preferably more than 60%.And intermediate layer adopts hydrophilic fibers or absorbent paper, liquid extending transversely coming fast can be passed to absorption diffusion layer, can make like this to absorb the superpower imbibition of diffusion layer and keep the ability of liquid to give full play of.The major function of described absorption diffusion layer is moisture absorption and moisturizing; Inventor also finds, if absorb diffusion layer, only adopt hydrophilic fibers, its moistening effect is undesirable, and the too high levels that adopts hydrophobic fiber or hydrophobic fiber is completely unfavorable for absorbing the moisture absorption of diffusion layer, absorption diffusion layer therefore of the present invention adopts hydrophilic fibers and adds a certain amount of hydrophobic fiber and can make moisture absorption and moisturizing all reach good effect simultaneously; Wherein, in the gross weight of described absorption diffusion layer, the content of hydrophobic fiber is below 50%, preferably below 20%.
As preferred embodiments of the present invention, the grammes per square metre of described vertical absorbed layer is between 50-350 gram/m, and the grammes per square metre in described intermediate layer is between 50-150 gram/m, and the grammes per square metre of described absorption diffusion layer is between 80-400 gram/m.
In the present invention, as preferred scheme, in described vertical absorbed layer, hydrophobic fiber is polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, hydrophobic chitin fiber, polypropylene/own synthetic fibre bicomponent fibre, nylon/polyethylene bicomponent fibre, one or more in terylene/nylon bicomponent fibre are with arbitrarily than mixing, hydrophilic fibers is bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Bacterial cellulose, water suction acrylic fiber, water suction polypropylene fiber, Lyocell fibers, calcium alginate fibre, water suction chitin fiber, carboxymethyl cellulose fiber, carboxyethyl cellulose fiber, acylation chitosan fiber, carboxymethyl chitosan fiber and derivant thereof are (as Aloe extraction solution, the hydrophilic fibers that cactus extraction etc. were processed) one or more in are with arbitrarily than mixing.
In the present invention, as preferred scheme, in described intermediate layer, hydrophilic fibers is that one or more in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, wood pulp cellulose, straw pulp fiber are with arbitrarily than mixing.
In the present invention, as preferred scheme, in described absorption diffusion layer, hydrophilic fibers is one or more mixing in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, super water suction cross-linked acrylic acid fiber, wood pulp cellulose, straw pulp fiber, and hydrophobic fiber is one or more mixing in polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, polypropylene/polyethylene bicomponent fibre, nylon/polyethylene bicomponent fibre, terylene/nylon bicomponent fibre.
The vertical absorbed layer of strong fluid aspirating drain dressing of the present invention generally can directly spread on wound surface.But for burn and scald, hypotonic and dry wound surface, use before this strong fluid aspirating drain dressing, need be in the dressing of the first application one deck of wound surface anti-adhesive, as: medical sterilization kpetrolatum gauze, be used for preventing and wound surface adhesion to there is lubricated, sticky wound, promote granulation to grow, promote the effect of wound healing.
In the present invention, prepare strong fluid aspirating drain dressing and can realize by following three kinds of modes.
First kind of way concrete steps are as follows:
1) make respectively vertical absorbed layer, intermediate layer and absorption diffusion layer;
2) by step 1) in vertical absorbed layer, intermediate layer and the absorption diffusion layer made by the order of vertical absorbed layer, intermediate layer and absorption diffusion layer, be combined with each other successively;
3) by step 2) product of system cuts, packs after sterilizing.
Second way concrete steps are as follows:
1) make respectively vertical absorbed layer and intermediate layer;
2) by step 1) in vertical absorbed layer and the intermediate layer made compound, obtain composite bed;
3) in step 2) composite bed on directly preparation absorb diffusion layer;
4) by step 3) product of system cuts, packs after sterilizing.
The third mode concrete steps are as follows:
1) make respectively intermediate layer and absorb diffusion layer;
2) by step 1) in the intermediate layer made and to absorb diffusion layer compound, obtain composite bed;
3) in step 2) composite bed on directly preparation vertical absorbed layer;
4) by step 3) product of system cuts, packs after sterilizing.
In the present invention, as preferred scheme, in described acupuncture course, needling density is no more than 400/ square centimeter.
An imbibition drainage system, comprises strong fluid aspirating drain dressing of the present invention and described strong fluid aspirating drain dressing is fixed on to the fixture of site of injury.Wherein the structure of fixture is for can realize any structure that dressing of the present invention is fixed on to site of injury, as passed through the forms such as bandage, buckle or stickers.
Compared to existing technology, beneficial effect of the present invention is:
1. the strong fluid aspirating drain dressing of the present invention use that can a plurality ofly stack up, or contact with each other and put together with crossover can be only to have one or morely directly to contact with the wound of required processing like this, when a plurality of strong fluid aspirating drain dressing is used simultaneously, only have one of them directly to contact with wound, secretions is shifted to another strong fluid aspirating drain dressing or its contiguous strong fluid aspirating drain dressing by capillarity by the strong fluid aspirating drain dressing from directly contacting with wound with antibacterial, one of them strong fluid aspirating drain dressing or direct and above-mentioned another strong fluid aspirating drain dressing contact that directly contacts wound, or contact with the above-mentioned strong fluid aspirating drain dressing that directly contacts wound by one or more strong fluid aspirating drain dressing of centre, realization is also shifted away the secretions drain of wound surface,
2. strong fluid aspirating drain dressing of the present invention can be cut into arbitrary shape, with difformity and the big or small wound surface of fitting; Can also be according to the external sepage drainage bag of clinical needs drain sinus tract fistula deep exudate;
3. strong fluid aspirating drain dressing of the present invention can be for coated very eurypalynous wound, and this wound includes but not limited to that human and animal's burn, infected wound, wound, diabetic foot wound, tumor wound, mycete hinder, wound, tenderness, leg ulcer, leprosy wound, amputation wound, chronic wounds, radiation injury, firearm injury, metallic weapon incision and the epidermis relevant to HIV hindered; While using strong fluid aspirating drain dressing of the present invention, be not limited to superficial cut, can also be inserted in gash or otch in conjunction with miscellaneous part equally, for imbibition and drain;
4. strong fluid aspirating drain dressing of the present invention not only can absorb wound exudate, and can make secretions, antibacterial, slough, biomembrane, matrix metalloproteinase etc. away from wound because of the capillary effect in this strong fluid aspirating drain dressing structure; This strong fluid aspirating drain dressing can remove downright bad tissue, removes the nutrient of biomembrane (biofilm), reduces the harmful cytokine of wound surface;
5. strong fluid aspirating drain dressing of the present invention can be for discharging the stench of wound; Due to the superpower absorbability of strong fluid aspirating drain dressing, can adsorb the stink that wound discharges, reduce stink to airborne discharge;
6. strong fluid aspirating drain dressing of the present invention has capillary effect, utilize the negative-pressure sucking that the water potential energy pressure differential at capillary tube two ends in fiber produces and secretions is discharged by the drainage of dressing, realize the transfer absorption of secretions, absorbed like this liquid can be transferred to the material position of relatively dry; In addition, because the outer surface of vertical absorbed layer is for relatively inviscid, so strong fluid aspirating drain dressing can cosily be faced wound when processing wound;
7. strong fluid aspirating drain dressing of the present invention can effectively promote the wound surface generation that newly granulates, and reduces edema and eschar, thereby accelerates the healing of wound surface;
8. strong fluid aspirating drain dressing of the present invention can also be wiped blood for operation, absorb sepage, absorb body fluids.
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Accompanying drawing explanation
Fig. 1 is the structural representation of strong fluid aspirating drain dressing of the present invention;
Fig. 2 is that the dark II degree of rat scald wound model necrosis progrediens suppresses respectively to organize interstitial area area (n=6) variation diagram in experiment;
Fig. 3 is that the dark II degree of rat scald wound model necrosis progrediens suppresses respectively to organize the scald wound degree of depth (n=6) variation diagram in experiment;
Fig. 4 is that during the dark II degree of rat scald wound inoculation SA model biomembrane suppresses to test, A group silver dyes rear optical microphotograph eyeglass photo;
Fig. 5 is that during the dark II degree of rat scald wound inoculation SA model biomembrane suppresses to test, B group silver dyes rear optical microphotograph eyeglass photo;
Fig. 6 is that during the dark II degree of rat scald wound inoculation SA model biomembrane suppresses to test, C group silver dyes rear optical microphotograph eyeglass photo;
Fig. 7 is that Diabetic Ulcers in Rats metalloproteases suppresses A, B in experiment, C group is measured situation at the MMP1 of day part;
Fig. 8 is that Diabetic Ulcers in Rats metalloproteases suppresses A, B in experiment, C group is measured situation at the MMP2 of day part.
The specific embodiment
EXAMPLE l
As shown in Figure 1, a kind of strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer 3: the polyster fibre that contains 65% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The bamboo carbon fiber of 35% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 350/ square centimeter; The grammes per square metre of making fabric is 250 grams/m;
Intermediate layer 2: the cotton fiber that contains 100% weight, its fibre number is 1.5-2.5 denier, length is 25-35 millimeter; After weighing, mix, then shredding, combing, lapping acupuncture become cloth; The grammes per square metre of making fabric is 80 grams/m;
Absorb diffusion layer 1: the super water suction cross-linked acrylic acid fiber that contains 35% weight, its fibre number is 2.0-2.7 denier, length is 10-15 millimeter; The wood pulp cellulose of 45% weight, its fibre number is 2.0-2.5 denier, length is 10-15 millimeter; The polyster fibre that contains 20% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; Three kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 350/ square centimeter; The grammes per square metre of making fabric is 320 grams/m; Then with needle point method, described three layers are combined with each other;
The fabric of preparation is cut into 10 * 10cm, then packing and through Co 60 sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 650 grams/m.
Embodiment 2
A strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the hydrophobic chitin fiber that contains 60% weight, its fibre number is 2.2 deniers, length is 51 millimeters; The viscose rayon of 40% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 400/ square centimeter; The grammes per square metre of making fabric is 200 grams/m;
Intermediate layer: the viscose rayon that contains 30% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The cotton fiber of 70% weight, its fibre number is 1.5-2.5 denier, length is 25-35 millimeter; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth; The grammes per square metre of making fabric is 80 grams/m;
Absorb diffusion layer: the bamboo carbon fiber that contains 35% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The viscose rayon of 40% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The polypropylene fiber of 25% weight, its fibre number is 2.0-2.5 denier, length is 38 millimeters; Three kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 350/ square centimeter; The grammes per square metre of making fabric is 320 grams/m;
Vertical absorbed layer, intermediate layer and absorption diffusion layer fabric are laid at the bottom of lapping machine on curtain as required, feeding needing machine, punch frequency is 200/ square centimeter, realizes the compound of treble cloths;
The fabric of preparation is cut into 10 * 10cm, then packing ethane via epoxyethane sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 600 grams/m.
Embodiment 3
A strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the polyster fibre that contains 60% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The cotton fiber of 40% weight, its fibre number is 1.5-2.5 denier, length is 25-35 millimeter; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 350/ square centimeter; The grammes per square metre of making fabric is 250 grams/m;
Intermediate layer: the viscose rayon that contains 30% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The bamboo fiber of 70% weight, its fibre number is 5-6 denier, length is 80-90 millimeter; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and the grammes per square metre of making fabric is 80 grams/m;
Absorb diffusion layer: the bamboo carbon fiber that contains 35% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The viscose rayon of 50% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter, the polyster fibre that contains 15% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; Three kinds of fibers mix through even after weighing in proportion respectively again, then shredding, and combing, lapping acupuncture become cloth, and needling density is 350/ square centimeter.The grammes per square metre of making fabric is 320 grams/m;
Vertical absorbed layer, intermediate layer and absorption diffusion layer fabric are superimposed as required, and putting into baking oven, to carry out hot melt compound;
The fabric of preparation is cut into 10 * 10cm, then packing ethane via epoxyethane sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 650 grams/m.
Embodiment 4
A strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the polypropylene fiber that contains 70% weight, its fibre number is 2.0-2.5 denier, length is 38 millimeters; The Lyocell fiber of 30% weight, its fibre number is 1.7 deniers, length is 51 millimeters; Two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, combing, lapping;
Intermediate layer: the viscose rayon that contains 30% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter; The cotton fiber of 70% weight, its fibre number is 1.5-2.5 denier, and length is 25-35 millimeter, and two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, combing, lapping acupuncture become cloth; The grammes per square metre of making fabric is 80 grams/m;
Absorb diffusion layer: the viscose rayon of 85% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter, the polyster fibre that contains 15% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter, two kinds of fibers mix through even after weighing in proportion respectively again, then shredding, combing, lapping acupuncture become cloth; Needling density is 350/ square centimeter, and the grammes per square metre of making fabric is 320 grams/m.
When the vertical absorbed layer of preparation, by intermediate layer with absorb diffusion layer fabric according to the order of sequence (absorb diffusion layer fabric under, intermediate layer fabric is upper) be placed on lapping machine at the bottom of on curtain, then start shredding, combing and lapping operation, make the fleece of vertical absorbed layer directly be layered on (absorption diffusion layer is in bottom) above intermediate layer, feed together needing machine, punch frequency is 150/ square centimeter, make the fiber of vertical absorbed layer sting intermediate layer a straight thrust to absorbing diffusion layer outside, treble cloths is combined with each other.The average grammes per square metre of vertical absorbed layer is 300 grams/m;
The fabric of preparation is cut into 10 * 10cm, then packing and through Co 60 sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 700 grams/m.
Detect test
Utilize the model experiment of mice burn to test the effect of strong fluid aspirating drain dressing of the present invention, specific experiment is as follows.
1. after acute injury, microbionation rat model wound surface antibacterial removes experiment
1.1 experiment groupings
36 of SD rats, between body weight 200～250g, tri-groups of minute A, B, C, 12 every group, the situation of specifically dividing into groups is in Table 1.
Table 1: the grouping of laboratory animal
| Group | Dispose | Number of animals (only) | Wound surface number (individual) |
| A | Strong fluid aspirating drain dressing | 12 | 12 |
| B | Common dressing | 12 | 12 |
| C | Blank group | 12 | 12 |
1.2 experimental procedure
1.2.1 modelling: each group rat is pressed to 2ml/kg intraperitoneal injection of anesthesia with 15% chloral hydrate respectively.After anaesthetizing successfully, ventricumbent position is fixed on extremity on rat operating console, with electric pet shaver, reject back chaeta, clear water rinses, 75% alcohol disinfecting, at every rat back side, with rustless steel self-made punching device, make the full thickness dermal wounds of diameter 3cm, local with hydrogen peroxide, hibitane, normal saline flushing, wound surface surrounding skin 75% alcohol disinfecting, sterile gauze is dried.
1.2.2 wound surface connects bacterium: by the concentration being equipped with, be 1 * 10
9the escherichia coli of cfu/ml (EC), staphylococcus aureus (SA), pseudomonas aeruginosa (PSA) suspension, drip 0.5ml in wound surface with 1ml syringe, treats its NATURAL DISTRIBUTION.After ten minutes, strong fluid aspirating drain dressing, common dressing are individually fixed in to the face of respectively forming, within 12 hours, change once, after 24 hours, observe.
1.2.3 wound surface antibacterial gathers: with aseptic cotton carrier, dip normal saline (at 5ml physiological saline solution in vitro), by wound surface one side direction opposite side, rolled, evenly smear wound surface once after, insert immediately in a dry sterile test tube, put into again after 1ml physiological saline solution is scrubbed dilution and be inoculated in MH culture dish, 37 ° of constant temperature culture are after 24 hours, and the bacterium colony of counting inoculated and cultured ware forms number (cfu); Wound surface inoculated bacteria is after ten minutes (means intervene before), after 24 hours, measure respectively wound surface EC, SA, PSA quantity; According to formula (after ten minutes count of bacteria value mean-24 hour after count of bacteria value mean)/count of bacteria value mean after ten minutes, calculate A, B, the removal rate comparison of C group to three kinds of different bacterium; All data are processed with SPSS16.0 statistical software, carry out respectively the multiple comparisons of variance analysis relatively and between a plurality of sample average, and P<0.05 is for there being significant difference.
1.3 wound surface bacteria cultivation results: carry out the collection of wound surface antibacterial, after inoculated and cultured, calculate and respectively organize bacterial number; Analyze comparing result in Table 2.
Table 2: the comparison (%) of 24h to wound surface EC, SA, PSA removal rate mean after wound
| Group | EC | SA | PSA |
| A | 78.82* | 76.11* | 82.36* |
| B | 3.57☆ | 3.40☆ | 3.77☆ |
| C | 1.96 | 2.01 | 1.49 |
* note: A group and B, C organize relatively, and P<0.05, has significant difference
☆ note: B group compares with C group, P>0.05, there was no significant difference
Result in table 2 shows, strong fluid aspirating drain dressing can effectively remove the malignant bacterias such as EC, PSA, SA in 24 hours.
2. the dark II degree of rat scald wound model necrosis progrediens suppresses experiment
2.1 experimental procedure
2.1.1 modelling: test is with reference to the copper pectination scalding model of Regas FC and Ehrlich HP invention, and special copper comb is scalded device, heavy 150g, by 4 outstanding broach, formed the wide 10mm of each broach, long 20mm, after being used for being heated, contact skin, form scald wound; Between broach, be 3 matrix gaps, each wide 5mm, long 20mm, does not contact skin during scald, and the region of formation is called interstitial area; Test the previous day by rat back electric hair cutter unhairing, clear water is cleaned, and avoids causing skin irritation.The 1% pentobarbital sodium intraperitoneal injection of anesthesia that gives 40mg/kg by the weight of animals, is fixed on animal experimental table, special copper comb is scalded to device and be immersed in boiled in advance boiling water (surveying water temperature is 100 ℃), and homogeneous heating 5 minutes, is stained with dry; First be placed on that rat back center line both sides are other opens 0.5cm place skin, do not apply any pressure, with skin corresponding time of contact be 20s; Both sides, back respectively make 4 scald wounds and three interstitial areas of not scalding between them thus.After wound, give monolayer oil gauze flap coverage, do not do other processing; Hinder and with scalpel, cut part wound tissue specimen in latter 2 hours; Specimen is that the part that 3 * 10mm comprises interstitial area and both sides thereof is scalded district's holostrome skin histology, puts in 10% paraformaldehyde and spends the night; After shifting out, specimen puts into come card Automation-tissue-dehydrating machine; Next day, paraffin embedding, after to be cooled fixing, did the thick section of 4 μ m, dried; HE dyeing, gradient alcohol dehydration, transparent to dimethylbenzene, row histological observation after neutral gum mounting, visible epidermal area degeneration necrosis, on skin corium, approximately 2/3 collagen homogenizing is red dyes, and in the lower little vessel lumen of 1/3 visible part, erythrocyte stops up, appendages of skin part cell has core to concentrate or cracking, meets dark II degree empyrosis wound surface feature.
2.1.2 grouping experiment: be divided into tri-groups of A, B, C after as stated above will 18 dark II degree of rats underwent scalding, every group 6, use respectively strong fluid aspirating drain dressing (A group), common dressing (B group), blank (C group) to process, wherein A group, B organize every 12 hours and change a dressing; After cutting part wound tissue specimen paraffin embedding, fixing section, HE dyeing by method described in 2.1.1 after 24 hours and 48 hours, observe; Use GraphPad Prism5.0 software to carry out statistical analysis to experimental data, interstitial area area and Wound depth represent with x ± s, relatively adopt paired t-test between two groups.P<0.05 is for there being significant difference.
2.2 experimental result
2.2.1 wound surface and interstitial area change: wound surface situation gross examination of skeletal muscle, comprise hair and interstitial area area, and have or not petechia or ecchymosis etc. occur, if any, be considered as necrosis.Digital camera is apart from the wound surface 20cm preservation of vertically making film, and the other steel ruler of placing of wound surface is as reference, and rear by Image pro5.0 image analysis software, detector gap district area change, the results are shown in Figure 2.
The result of Fig. 2 shows: after scald, and B, C group interstitial area area continuous decrease, A group 24 hours is long-pending below to decline after scalding slightly, and 48 hours long-pending below remains unchanged substantially, and two time points organizes and are compared with B, C, equal P<0.05.Illustrate that A group therapeutic effect is obvious, limited the necrosis progrediens of interstitial area.
2.2.2 Wound depth detects: HE stained is put in to optical microphotograph Microscopic observation burn wound, with horn cell swelling, collagenous degeneration homogenizing is red to be dyed for index, determine Wound depth, and use NIF image software, image preserved in record, then uses Image pro5.0 image analysis software, calculates Wound depth; Each is organized each time point and observes 3 sections, and 5 positions are got in every section, average, and the results are shown in Figure 3.
The result of Fig. 3 shows: Wound depth B, C group after scald all has intensification in various degree, and A group Wound depth is tending towards reducing.Between each time point group, relatively, the A group degree of depth is minimum, and B group is taken second place, and C organizes maximum; A group and B, C organize relatively, P<0.05; B group compares with C group, P>0.05.Illustrate that the treatment of A group produces effect, and has limited the intensification of Wound depth.
3. the dark II degree of rat scald wound inoculation SA model biomembrane suppresses experiment
3.1 experimental procedures:
3.1.1 modelling: 3 SD rats are prepared the dark II degree of rat scald wound model by the method for above-mentioned 2.1.1, then by the method for above-mentioned 1.2.1 and 1.2.2, carry out wound surface SA inoculation and make the dark II degree of rat scald wound inoculation SA model.
3.1.2 experiment grouping: 3 rats are divided into tri-groups of A, B, C, every group 1, use respectively strong fluid aspirating drain dressing of the present invention (A group), common dressing (B group), space management (C group), wherein A group, B organize every 12 hours and change a dressing; Within 7 days, cut respectively after 3 * 10mm size inoculation wound tissue is processed by following argentation and observe.The results are shown in Figure 4-6.
Argentation treatment step is as follows: 1., through repeatedly fully rinsing of sterile saline, remove the bacterium that swims; 2. fixing 1h in 25% glutaraldehyde PBS solution; 3. distilled water cleans 1min; 4. saturated calcium chloride solution is in conjunction with 15min; 5. distilled water cleans 1min; 6. 5% silver nitrate solution reacts 15min; 7. 1% hydroquinone solution colour developing 2min; 8. distilled water rinsing 1min; 9. the fixing 2min of 5% hypo solution; 10. distilled water rinsing 1min.
3.2 experimental result
Fig. 4 is that A group silver dyes rear optical microphotograph eyeglass photo, and the stain being scattered as seen or black speck, without the black cotton-shaped film sample thing dying; Fig. 5 is that B group silver dyes rear optical microscope photograph, blackly in figure dyes part to be byssaceous film sample thing be SA biomembrane; Fig. 6 is that C group silver dyes rear optical microscope photograph, and visible antibacterial assembles agglomerating, forms large stretch of SA biomembrane therebetween.Result shows the significantly biomembranous formation of anti-bacteria of strong fluid aspirating drain dressing.
4. Diabetic Ulcers in Rats metalloproteases suppresses experiment
4.1 experimental procedure
4.1.1 modelling: 3 Wistar rats, body weight 200～250g, 12h fasting before experiment, quantitatively drinking-water; Experiment was weighed the same day, and tail vein blood and collection urine, measure respectively basic blood glucose and glucose in urine with blood glucose meter and test paper method, then presses 150mg/kg body weight lumbar injection 3% alloxan; After 1 week when animal blood glucose concentration is greater than 11mmol/L and glucose in urine is ++++(>20g/L) time, can think that diabetes model copies successfully.Get above-mentioned imagineering's 3 of diabetes rats, with 3% pentobarbital sodium (25mg/kg) abdominal cavity, inject after anesthesia, hair is shaved at back, routine disinfection; Under aseptic condition, with special card punch, in spinal column both sides, Mus back of the body middle part, each makes a call to a circular hole, be deep to subcutaneous, diameter 1.8cm, wound surface area is 2.54cm
2; After hemostasis, use respectively strong fluid aspirating drain dressing (A group), common dressing (B group), blank (C group) to process, wherein A group, B organize every 12 hours and change a dressing; Every treated animal list cage is fed, quantitatively drinking-water and feeding.Appetite, amount of drinking water, body weight and the glucose in urine of measuring animal every day change, and survey weekly blood glucose 1 time; Adopt supplementary injection alloxan or insulin (2u/ only) mode to maintain diabetic animal blood glucose between 11～16.5mmol/L.
4.1.2 experimental technique: cut 4 * 3 * 3mm granulation tissue in wound surface central authorities in the 1st, 4,7 days respectively after wound surface is processed, use immediately liquid nitrogen flash freezer, proceed to frozen 2 months of-70 ℃ of refrigerators after 48h; Total RNA application Trizol test kit extracts and is placed on-70 ℃ of preservations; The amplification of RT-PCR test kit MMPI, the MMP2 that utilize Promega company, finally measure each product density value by Band-scan scanning system, and all products, all through order-checking, confirm to be respectively MMP1, MMP2; The density value of each each index of time point represents with X ± S, with non-paired t test, analyzes, and P<0.05 is for there being significant difference.The results are shown in Figure 7 and Fig. 8.
4.2 experimental result
Fig. 7, Fig. 8 are that A, B, C group are measured situation at MMP1, the MMP2 of day part, result shows, strong fluid aspirating drain dressing can make MMP1 and the MMP2 in diabetes chronic wound surface significantly decline, and compares with matched group and blank group numerical value, and P<0.05 has significant difference.
In sum, most of pathogenic bacteria, slough, biomembrane and the matrix metalloproteinase of the removable wound surface of strong fluid aspirating drain dressing of the present invention.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, the variation of any unsubstantiality that those skilled in the art does on basis of the present invention and replacement all belong to the present invention's scope required for protection.
Claims (10)
1. a strong fluid aspirating drain dressing, it is characterized in that, it comprises vertical absorbed layer, intermediate layer and the absorption diffusion layer of laminating successively, described vertical absorbed layer is that raw material is made by hydrophobic fiber and hydrophilic fibers, wherein, in the gross weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%; Described intermediate layer is that hydrophilic fibers or absorbent paper are made; Described absorption diffusion layer by hydrophilic fibers and in the gross weight that absorbs diffusion layer the hydrophobic fiber below 50% make.
2. strong fluid aspirating drain dressing according to claim 1, it is characterized in that, the grammes per square metre of described vertical absorbed layer is between 50-350 gram/m, and the grammes per square metre in described intermediate layer is between 50-150 gram/m, and the grammes per square metre of described absorption diffusion layer is between 80-400 gram/m.
3. strong fluid aspirating drain dressing according to claim 1, it is characterized in that, in described vertical absorbed layer, hydrophobic fiber is polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, hydrophobic chitin fiber, polypropylene/own synthetic fibre bicomponent fibre, nylon/polyethylene bicomponent fibre, one or more in terylene/nylon bicomponent fibre are with arbitrarily than mixing, hydrophilic fibers is bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Bacterial cellulose, water suction acrylic fiber, water suction polypropylene fiber, Lyocell fibers, calcium alginate fibre, water suction chitin fiber, carboxymethyl cellulose fiber, carboxyethyl cellulose fiber, acylation chitosan fiber, one or more in carboxymethyl chitosan fiber and derivant thereof are with arbitrarily than mixing.
4. strong fluid aspirating drain dressing according to claim 1, it is characterized in that, in described intermediate layer, hydrophilic fibers is that one or more in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, wood pulp cellulose, straw pulp fiber are with arbitrarily than mixing.
5. strong fluid aspirating drain dressing according to claim 1, it is characterized in that, in described absorption diffusion layer, hydrophilic fibers is bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, super water suction cross-linked acrylic acid fiber, wood pulp cellulose, one or more mixing in straw pulp fiber, hydrophobic fiber is polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, polypropylene/polyethylene bicomponent fibre, nylon/polyethylene bicomponent fibre, one or more mixing in terylene/nylon bicomponent fibre.
6. a preparation method for strong fluid aspirating drain dressing as claimed in claim 1, is characterized in that, its step is as follows:
1) make respectively vertical absorbed layer, intermediate layer and absorption diffusion layer;
2) by step 1) in vertical absorbed layer, intermediate layer and the absorption diffusion layer made by the order of vertical absorbed layer, intermediate layer and absorption diffusion layer, be combined with each other successively;
3) by step 2) product of system cuts, packs after sterilizing.
7. a preparation method for strong fluid aspirating drain dressing as claimed in claim 1, is characterized in that, its step is as follows:
1) make respectively vertical absorbed layer and intermediate layer;
2) by step 1) in vertical absorbed layer and the intermediate layer made compound, obtain composite bed;
3) in step 2) composite bed on directly preparation absorb diffusion layer;
4) by step 3) product of system cuts, packs after sterilizing.
8. a preparation method for strong fluid aspirating drain dressing as claimed in claim 1, is characterized in that, its step is as follows:
1) make respectively intermediate layer and absorb diffusion layer;
2) by step 1) in the intermediate layer made and to absorb diffusion layer compound, obtain composite bed;
3) in step 2) composite bed on directly preparation vertical absorbed layer;
4) by step 3) product of system cuts, packs after sterilizing.
9. according to the preparation method described in claim 6-8 any one, it is characterized in that, in described acupuncture course, needling density is no more than 400/ square centimeter.
10. an imbibition drainage system, is characterized in that: it comprise strong fluid aspirating drain dressing as described in claim 1-5 any one and by as described in strong fluid aspirating drain dressing be fixed on the fixture of site of injury.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410240612.8A CN103990174B (en) | 2014-05-30 | 2014-05-30 | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410240612.8A CN103990174B (en) | 2014-05-30 | 2014-05-30 | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103990174A true CN103990174A (en) | 2014-08-20 |
| CN103990174B CN103990174B (en) | 2015-04-15 |
Family
ID=51304669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410240612.8A Active CN103990174B (en) | 2014-05-30 | 2014-05-30 | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103990174B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597136A (en) * | 2016-02-01 | 2016-05-25 | 上海昌颌医药科技有限公司 | Moisture-transfer and fast drying wound dressing |
| CN111686295A (en) * | 2020-06-24 | 2020-09-22 | 重庆理工大学 | Seepage self-adjusting composite dressing and preparation method thereof |
| CN114592263A (en) * | 2022-03-14 | 2022-06-07 | 苏州雷池新材料科技有限公司 | Preparation method of degradable alginic acid medical fabric |
| CN114712088A (en) * | 2022-04-01 | 2022-07-08 | 浙江隆腾医用新材料有限公司 | Carboxymethyl cellulose wound dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552244B1 (en) * | 1999-01-09 | 2003-04-22 | Bristol-Myers Squibb Company | Multi-layered wound dressing |
| CN101252902A (en) * | 2005-08-31 | 2008-08-27 | 科洛普拉斯特公司 | An absorbent wound care device |
| CN102112078A (en) * | 2008-08-01 | 2011-06-29 | 美利肯公司 | Composite article suitable for use as wound dressing |
| CN103655046A (en) * | 2013-12-03 | 2014-03-26 | 佛山市优特医疗科技有限公司 | Wound dressing with three-layer structure and preparation method of wound dressing |
-
2014
- 2014-05-30 CN CN201410240612.8A patent/CN103990174B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552244B1 (en) * | 1999-01-09 | 2003-04-22 | Bristol-Myers Squibb Company | Multi-layered wound dressing |
| CN101252902A (en) * | 2005-08-31 | 2008-08-27 | 科洛普拉斯特公司 | An absorbent wound care device |
| CN102112078A (en) * | 2008-08-01 | 2011-06-29 | 美利肯公司 | Composite article suitable for use as wound dressing |
| CN103655046A (en) * | 2013-12-03 | 2014-03-26 | 佛山市优特医疗科技有限公司 | Wound dressing with three-layer structure and preparation method of wound dressing |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597136A (en) * | 2016-02-01 | 2016-05-25 | 上海昌颌医药科技有限公司 | Moisture-transfer and fast drying wound dressing |
| CN111686295A (en) * | 2020-06-24 | 2020-09-22 | 重庆理工大学 | Seepage self-adjusting composite dressing and preparation method thereof |
| CN114592263A (en) * | 2022-03-14 | 2022-06-07 | 苏州雷池新材料科技有限公司 | Preparation method of degradable alginic acid medical fabric |
| CN114712088A (en) * | 2022-04-01 | 2022-07-08 | 浙江隆腾医用新材料有限公司 | Carboxymethyl cellulose wound dressing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103990174B (en) | 2015-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1942851B1 (en) | Absorptive element to be mounted on human or animal skin surfaces | |
| Martin et al. | Current trends in the development of wound dressings, biomaterials and devices | |
| CN102341130B (en) | Wound dressing, the method and apparatus for manufacturing wound dressing and its storage and purposes | |
| CN100400019C (en) | Emergency wound dressing and its preparation method | |
| DE602004002717T2 (en) | Leaf-shaped wound dressing of microbial cellulose containing PHMB for chronic wounds | |
| Thomas | Surgical dressings and wound management | |
| US20080215020A1 (en) | Apparatuses and methods for healing wounds | |
| EP2185206B1 (en) | Haemostatic wound care article | |
| EP2809363B1 (en) | Wound care article comprising at least one surface having abrasive properties | |
| RU149063U1 (en) | ANTI-MICROBIAL ACTION BAND FOR HEALING | |
| CN103990174B (en) | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device | |
| US20070293799A1 (en) | Nano-silver wound dressing | |
| O'Shaughnessy et al. | Calcium alginate dressings promote healing of split skin graft donor sites | |
| DE102009031992A1 (en) | Device for negative pressure therapy of wounds | |
| Thomas et al. | Testing dressings and wound management materials | |
| CN105597136A (en) | Moisture-transfer and fast drying wound dressing | |
| Öztürk et al. | Wound healing: a new approach to the topical wound care | |
| DE102012100842A1 (en) | Wound care article useful e.g. for treating bleeding wounds, comprises surface having abrasive properties, which is designed such that wound care article is suitable for breaking bio-films in a wound, and/or for controlling wound exudation | |
| DE102007063294A1 (en) | Wound dressing for use in kit for acute, emergency, military medical or chronic supply unit and for controlling exudate, treating chronic, acute, bleeding wounds, burn wounds or traumatic wounds, comprises wound exudate absorbing body | |
| Barnett et al. | Studies of wound healing and the effects of dressings | |
| CN110623792B (en) | Medical dressing and preparation method thereof | |
| DE202006016821U1 (en) | Absorptive element for mounting on human or animal skin surfaces in area of wounds, has inner layer filled with osmotically active substances such that osmotic pressure can be applied to wound containing wound fluids | |
| JP4486304B2 (en) | Microbial cellulosic wound dressings for the treatment of chronic wounds | |
| CN105727360A (en) | Biological material applied to operative skin incision and infectious and non-infectious wound surfaces and application thereof | |
| CN111557790A (en) | Antibacterial and disinfectant nanofiber medical dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device Effective date of registration: 20200213 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2020980000243 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210528 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2020980000243 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The utility model relates to a strong suction drainage dressing, a preparation method and a suction drainage device thereof Effective date of registration: 20210617 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: Y2021980004841 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220704 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2021980004841 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A strong liquid suction and drainage dressing, its preparation method and liquid suction and drainage device Effective date of registration: 20220711 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2022980010170 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230918 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2022980010170 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A strong suction and drainage dressing, its preparation method, and suction and drainage device Effective date of registration: 20231018 Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2023980061630 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2023980061630 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A strong suction and drainage dressing and its preparation method and suction and drainage device Granted publication date: 20150415 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU ARAHELIO BIOLOGICAL TECHNOLOGY CO.,LTD. Registration number: Y2024980008787 |