CN103954486B - Prepare the adding pressure type reaction unit of cell block - Google Patents
Prepare the adding pressure type reaction unit of cell block Download PDFInfo
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- CN103954486B CN103954486B CN201410164349.9A CN201410164349A CN103954486B CN 103954486 B CN103954486 B CN 103954486B CN 201410164349 A CN201410164349 A CN 201410164349A CN 103954486 B CN103954486 B CN 103954486B
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- pipe body
- mounting block
- reaction unit
- pressure type
- conduit
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 27
- 239000012528 membrane Substances 0.000 claims abstract description 34
- 230000003139 buffering effect Effects 0.000 claims description 5
- 238000000605 extraction Methods 0.000 abstract description 8
- 238000000034 method Methods 0.000 description 14
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 238000002386 leaching Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 239000001993 wax Substances 0.000 description 8
- 239000012188 paraffin wax Substances 0.000 description 6
- 238000000151 deposition Methods 0.000 description 4
- 238000004043 dyeing Methods 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012189 cellwax Substances 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000012151 immunohistochemical method Methods 0.000 description 1
- -1 moisture Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
The present invention provides a kind of adding pressure type reaction unit preparing cell block, comprises reaction tubes, semi-permeable membranes, extraction device and pressurizing device. Reaction tubes comprises the first pipe body and the 2nd pipe body. First pipe body is hollow cylindrical, and the top of the first pipe body and bottom are open state. The detachable bottom being arranged at the first pipe body of 2nd pipe body, the 2nd pipe body is hollow structure, and the top of the 2nd pipe body is open state, and bottom has perforate. Semi-permeable membranes is arranged between the first pipe body and the 2nd pipe body. Extracting device, comprise mounting block and conduit, mounting block is hollow structure, and open top and the 2nd pipe body bottom opening of mounting block are fixedly connected, and one end of the bottom opening of mounting block and conduit is fixedly connected. Pressurizing device is connected with the other end of conduit, by conduit for providing malleation or negative pressure bottom the 2nd pipe body.
Description
Technical field
The present invention relates to medical electronics instrument field, and in particular to a kind of adding pressure type reaction unit preparing cell block.
Background technology
Medically processing body fluid cell is generally that the cell with liquid is directly coated with on the glass sheet, then is observed by microscope. Along with the development of cytopathology in recent years, the limitation of the common smear that above this kind of routine techniques makes is more and more obvious, such as smear Existence and uniquenss, can not copy; Can not forever retain; Hinder emerging pathological technique such as the application of immunohistochemical methods, molecular pathology technology.
Cell block is then fix carrying out paraffin after the cell extraction in liquid, makes the form of allied organization's section after fixing. This method solve above-mentioned common smear Problems existing, also can avoid the doctor-patient dispute because smear damage, loss etc. may cause. Make cell block is also the basis preparing organization chip simultaneously, and this technology will be widely used in cytopathology field.
Acquirement and the leaching wax of cell mass are necessary processes prepared by cell block, and in existing cell block preparation process, the acquirement of cell block pours the body fluid of extraction into test tube, the supernatant liquor that test tube top contains the interference components such as blood will be removed after the test tube high speed centrifugation some time, pour out being deposited on the cell mass bottom test tube. But, due to cell mass thinner thickness, and with test tube bottom there is bigger adhesive power, it is very difficult to cell mass is poured out. Identical problem, also exists in leaching wax process.
In addition, utilize existing test tube carrying out dewatering, transparent, dyeing, the process such as leaching wax time, reagent covers above cell, therefore, usually occur that the cell leaching of bottom and centre fails fully to soak reagent, thus seriously have impact on the making quality of cell block.
Summary of the invention
The present invention takes out and cell immersion reagent problem not fully to overcome the existing fast reaction unit cell mass difficulty of cell wax of preparing, it is provided that a kind of adding pressure type reaction unit preparing cell block.
In order to realize above-mentioned purpose, the present invention provides a kind of adding pressure type reaction unit preparing cell block, comprises reaction tubes, semi-permeable membranes, extraction device and pressurizing device.Reaction tubes comprises the first pipe body and the 2nd pipe body. First pipe body is hollow cylindrical, and the top of the first pipe body and bottom are open state. The detachable bottom being arranged at the first pipe body of 2nd pipe body, the 2nd pipe body is hollow structure, and the top of the 2nd pipe body is open state, and bottom has perforate. Semi-permeable membranes is arranged between the first pipe body and the 2nd pipe body. Extracting device and comprise mounting block and conduit, mounting block is hollow structure, and open top and the 2nd pipe body bottom opening of mounting block are fixedly connected, and one end of the bottom opening of mounting block and conduit is fixedly connected. Pressurizing device is connected with the other end of conduit, by conduit for providing malleation or negative pressure bottom the 2nd pipe body.
In one embodiment of the invention, the upper surface of semi-permeable membranes and lower surface are all coated with wire netting, and wire netting is arranged between the first pipe body and the 2nd pipe body.
In one embodiment of the invention, the 2nd pipe body is the inverted round stage shape of hollow, and the area being positioned at the perforate bottom the 2nd pipe body is less than the area bottom the 2nd pipe body.
In one embodiment of the invention, the top of mounting block is provided with the groove in inverted round stage shape corresponding with the 2nd pipe body.
In one embodiment of the invention, the sidewall of groove is provided with buffering part.
In one embodiment of the invention, the outer, top of mounting block is provided with working arm.
In one embodiment of the invention, the outer side wall of the first pipe body is provided with stop block, and the lower rim of stop block and the connection face of the first pipe body and the 2nd pipe body are in the same plane.
In one embodiment of the invention, the outer, top of the first pipe body is provided with a boss.
In sum, the present invention by between the first pipe body and the 2nd pipe body arrange be used for collecting cell agglomerate semi-permeable membranes and due to the first pipe body and the 2nd pipe body be detachable setting, thus after cell mass is deposited on semi-permeable membranes, the first pipe body is separated with the 2nd pipe body, the semi-permeable membranes depositing cell mass is taken out, then the cell mass on semi-permeable membranes is taken off. This structure can fast, convenient and take out cell mass with no damage.
In addition, arranging the pressurizing device extracting device and being connected with extraction device in the bottom of the 2nd pipe body, when carrying out collecting cell agglomerate, pressurizing device is apply malleation or negative pressure bottom the 2nd pipe body by extracting device circulation. Malleation and the circulation of negative pressure apply with traditional utilize centrifuging collecting cell agglomerate compared with, greatly accelerate the collection of cell mass. And further, when in dehydration, transparent, dyeing, the leaching process such as wax, pressurizing device circulation is that the 2nd pipe body provides malleation or negative pressure, so that all cells in cell mass can fully soak corresponding chemical reagent, it is to increase prepare the quality of cell block.
For above and other objects of the present invention, feature and advantage can be become apparent, better embodiment cited below particularly, and coordinate accompanying drawing, it is described in detail below.
Accompanying drawing explanation
Fig. 1 show the structural representation of the adding pressure type reaction unit preparing cell block that one embodiment of the invention provides.
Embodiment
As shown in Figure 1, the present invention provides the adding pressure type reaction unit preparing cell block to comprise reaction tubes 1, semi-permeable membranes 2, extract device 3 and pressurizing device 4. Reaction tubes 1 comprises the first pipe body 11 and the 2nd pipe body 12. First pipe body 11 is hollow cylindrical, and the top of the first pipe body 11 and bottom are open state. The detachable bottom being arranged at the first pipe body 11 of 2nd pipe body 12, the 2nd pipe body 12 is hollow structure, and the top of the 2nd pipe body 12 is open state, and bottom has perforate 121.Semi-permeable membranes 2 is arranged between the first pipe body 11 and the 2nd pipe body 12. Extracting device 3 and comprise mounting block 31 and conduit 32, mounting block 31 is hollow structure, and open top and the 2nd pipe body 12 bottom opening 121 of mounting block 31 are fixedly connected, and one end of the bottom opening of mounting block 31 and conduit 32 is fixedly connected. Pressurizing device 4 is connected with the other end of conduit 32, by conduit 32 for providing malleation or negative pressure bottom the 2nd pipe body 12.
The semi-permeable membranes 2 being used for collecting cell agglomerate is set between the first pipe body 11 and the 2nd pipe body 12, in use, cellular liquid is after the first pipe body 11 and semi-permeable membranes 2, cell mass is deposited on semi-permeable membranes 2, and the small-molecule substances such as moisture are then flowed in the waste liquid bottle being connected with conduit 32 through the 2nd pipe body 12 and extraction device 3 by semi-permeable membranes 2. Owing to the first pipe body 11 and the 2nd pipe body 12 are detachable settings, thus after cell mass is deposited on semi-permeable membranes 2, first pipe body 11 is separated with the 2nd pipe body 12, the semi-permeable membranes 2 depositing cell mass is taken out, being taken off by cell mass on semi-permeable membranes 2, this structure can take out the cell mass being deposited on semi-permeable membranes 2 fast, conveniently and with no damage again.
In addition, arranging the pressurizing device 4 extracting device 3 and being connected with extraction device 3 in the bottom of the 2nd pipe body 12, when carrying out cell mass and collect, pressurizing device 4 is apply malleation or negative pressure bottom the 2nd pipe body 12 by extracting device 3 circulation. When applying malleation, accelerate the small-molecule substances such as the moisture in the first pipe body 11 by semi-permeable membranes 2, accelerate the collection of cell mass. And when the cell mass being deposited on semi-permeable membranes 2 more thus block the small-molecule substances such as moisture pass through time, pressurizing device 4 is for providing negative pressure bottom the 2nd pipe body 12, again the cell mass being deposited on semi-permeable membranes 2 is pushed back in the cellular liquid in the first pipe body 11, applying malleation afterwards again, the materials such as moisture are again by the semi-permeable membranes 2 without blocking. With traditional utilize centrifuging collecting cell agglomerate compared with, this kind of method accelerates the collection of cell mass greatly.
Further, when in dehydration, transparent, dyeing, the leaching process such as wax, pressurizing device circulation provides malleation or negative pressure for the 2nd pipe body 12, under negative pressure affects, cell mass repeatedly pushes back in the reagent in the first pipe body 11, so that all cells in cell mass can fully soak the corresponding chemical reagent being positioned at the first pipe body 11, substantially increase the quality preparing cell block.
Leaching wax is the indispensable process preparing cell block, and paraffin temperature influence is easy to solidify, and thus must paraffin pipeline and reaction tubes 1 be heated in this process, thus prevents the problem that paraffin occurs in leaching wax process. In the present embodiment, for preventing paraffin from solidifying on semi-permeable membranes 2, thus upper and lower surface at semi-permeable membranes 2 arranges wire netting 5. Wire netting 5 has good heat conductivility, fast the temperature of reaction tubes 1 can be passed to semi-permeable membranes 2 so that the temperature of semi-permeable membranes 3 maintains 60 DEG C～70 DEG C, so that paraffin keeps liquid, in addition, semi-permeable membranes 2 also can be played a supporting role by wire netting 5.
Glass or plastic material it is generally due to reaction tubes 1, chipping for preventing bottom the 2nd pipe body 12, thus the 2nd pipe body 12 is set to the inverted round stage shape in hollow, and the area being positioned at the perforate 121 bottom the 2nd pipe body 12 is less than the area bottom the 2nd pipe body 12.And the top of the mounting block 31 corresponding with this inverted round stage shape the 2nd pipe body 12 is provided with the groove 311 in inverted round stage shape. Inverted round stage structure can better protect sidewall and the bottom of the 2nd pipe body 12, and the liquid such as moisture, reagent also can be concentrated in the mounting block 31 flowing into hollow by this structure simultaneously, prevents the fluid seepage such as moisture, reagent.
In addition, for preventing the fluid seepage bottom the 2nd pipe body 12 further, the area arranging the perforate 121 bottom the 2nd pipe body 12 is less than the area bottom the 2nd pipe body 12, and the center of circle, bottom of the center of circle of this perforate 121 and the 2nd pipe body 12 coincides. Liquid is played the effect stopping and collecting by the edge of perforate 121, thus reaches the technique effect of antiseep.
For better protecting the bottom of the 2nd pipe body 12, the sidewall at groove 311 is provided with buffering part 6. Buffering part 6 is flexible material, and when the 2nd pipe body 12 contacts fixing with groove 311, contact pressure is cushioned by buffering part 6, prevents contact pressure excessive and makes the 2nd pipe body 12 chipping. Further sfgd. is, the outer, top of mounting block 31 is provided with working arm 312. And the outer side wall of the first pipe body 11 corresponding with this working arm 312 is provided with stop block 111, the lower rim of stop block 111 and the connection face of the first pipe body 11 and the 2nd pipe body 12 are in the same plane. When mounting block 31 rise be fixedly connected with the 2nd pipe body 12 time, working arm 312 is stopped by stop block 111, prevents mounting block 31 from too rising, so that the bottom of the 2nd pipe body 12 is squeezed and chipping.
For convenience of depositing of reaction tubes 1, the outer, top of the first pipe body 11 is provided with a boss 112. Boss 112 is placed in the top of test-tube stand, so that reaction tubes 1 can be fixed on test-tube stand, conveniently deposits.
In sum, the present invention by between the first pipe body 11 and the 2nd pipe body 12 arrange be used for collecting cell agglomerate semi-permeable membranes 2 and due to the first pipe body 11 and the 2nd pipe body 12 be detachable setting, thus after cell mass is deposited on semi-permeable membranes 2, first pipe body 11 is separated with the 2nd pipe body 12, the semi-permeable membranes 2 depositing cell mass is taken out, then the cell mass on semi-permeable membranes 2 is taken off. This structure can fast, convenient and take out cell mass with no damage.
In addition, arranging the pressurizing device 4 extracting device 3 and being connected with extraction device 3 in the bottom of the 2nd pipe body 12, when carrying out collecting cell agglomerate, pressurizing device 4 is apply malleation or negative pressure bottom the 2nd pipe body 12 by extracting device circulation. Malleation and the circulation of negative pressure apply with traditional utilize centrifuging collecting cell agglomerate compared with, greatly accelerate the collection of cell mass. And it is further, when in dehydration, transparent, dyeing, the leaching process such as wax, pressurizing device 4 circulates as the 2nd pipe body 12 provides malleation or negative pressure, so that all cells in cell mass can fully soak corresponding chemical reagent, it is to increase prepare the quality of cell block.
Although the present invention is disclosed as above by better embodiment; but and be not used to limit the present invention, any know this those skilled in the art, without departing from the spirit and scope of the present invention; can doing a little change and retouching, therefore protection scope of the present invention is when being as the criterion depending on the scope that claim book is claimed.
Claims (6)
1. prepare the adding pressure type reaction unit of cell block for one kind, it is characterised in that, comprising:
Reaction tubes, comprises the first pipe body and the 2nd pipe body;
First pipe body is hollow cylindrical, and the top of described first pipe body and bottom are open state, and the outer side wall of the first pipe body is provided with stop block, and the lower rim of described stop block and the connection face of described first pipe body and the 2nd pipe body are in the same plane;
2nd pipe body, the detachable bottom being arranged at described first pipe body, described 2nd pipe body is hollow structure, and the top of described 2nd pipe body is open state, and bottom has perforate;
Semi-permeable membranes, is arranged between described first pipe body and the 2nd pipe body;
Extract device, comprising mounting block and conduit, described mounting block is hollow structure, and open top and the described 2nd pipe body bottom opening of described mounting block are fixedly connected, and one end of the bottom opening of described mounting block and conduit is fixedly connected, the outer, top of mounting block is provided with working arm;
Pressurizing device, is connected with the other end of described conduit, by conduit for providing malleation or negative pressure bottom the 2nd pipe body.
2. the adding pressure type reaction unit preparing cell block according to claim 1, it is characterised in that, the upper surface of described semi-permeable membranes and lower surface are all coated with wire netting, and described wire netting is arranged between described first pipe body and the 2nd pipe body.
3. the adding pressure type reaction unit preparing cell block according to claim 1, it is characterised in that, described 2nd pipe body is the inverted round stage shape of hollow, and the area being positioned at the perforate bottom the 2nd pipe body is less than the area bottom the 2nd pipe body.
4. the adding pressure type reaction unit preparing cell block according to claim 3, it is characterised in that, the top of described mounting block is provided with the groove in inverted round stage shape corresponding with described 2nd pipe body.
5. the adding pressure type reaction unit preparing cell block according to claim 4, it is characterised in that, the sidewall of described groove is provided with buffering part.
6. the adding pressure type reaction unit preparing cell block according to claim 1, it is characterised in that, the outer, top of described first pipe body is provided with a boss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410164349.9A CN103954486B (en) | 2014-04-23 | 2014-04-23 | Prepare the adding pressure type reaction unit of cell block |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410164349.9A CN103954486B (en) | 2014-04-23 | 2014-04-23 | Prepare the adding pressure type reaction unit of cell block |
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| Publication Number | Publication Date |
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| CN103954486A CN103954486A (en) | 2014-07-30 |
| CN103954486B true CN103954486B (en) | 2016-06-15 |
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| CN201410164349.9A Active CN103954486B (en) | 2014-04-23 | 2014-04-23 | Prepare the adding pressure type reaction unit of cell block |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104990780B (en) * | 2015-07-26 | 2017-10-17 | 赵稳兴 | A kind of method for making cell block |
| CN113390692B (en) * | 2021-05-24 | 2023-02-28 | 杭州电子科技大学 | Centrifugal test tube for automatically preparing cell wax block |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7541161B2 (en) * | 2002-10-31 | 2009-06-02 | University Of Massachusetts | Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins |
| CN101992136B (en) * | 2010-09-30 | 2012-09-05 | 何洪敏 | Combined centrifuge tube for preparing cell wax blocks by using exfoliated cells |
| CN201841020U (en) * | 2010-10-26 | 2011-05-25 | 徐海苗 | Filtering type moulding centrifugal tube for manufacturing cell wax block |
| CN103543057B (en) * | 2013-11-13 | 2015-12-02 | 何鑫 | The Combined centrifuge tube of cytology wax stone is prepared for micro-cast-off cells |
| CN203908835U (en) * | 2014-04-23 | 2014-10-29 | 杭州电子科技大学 | Pressurizing reaction device for preparing cell paraffin block |
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Effective date of registration: 20200908 Address after: 242000 under the viaduct of fufu South Road, Jingchuan Town, Jingxian County, Xuancheng City, Anhui Province Patentee after: Jingxian GUSHENG Information Technology Co.,Ltd. Address before: 310000 401, 403 and 405, 4 building, 2 building, 353 Shaoxing Road, Hangzhou, Zhejiang. Patentee before: Hangzhou SuperSafety Co.,Ltd. |
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Effective date of registration: 20201118 Address after: 235100 Qianlong Lake Industrial Park, Suixi Town, Suixi County, Huaibei, Anhui Patentee after: HUAIBEI RUJIA MEDICAL TECHNOLOGY Co.,Ltd. Address before: 242000 under the viaduct of fufu South Road, Jingchuan Town, Jingxian County, Xuancheng City, Anhui Province Patentee before: Jingxian GUSHENG Information Technology Co.,Ltd. |
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Effective date of registration: 20231214 Address after: 200120, 2nd Floor, Building 2, No. 356 Longgui Road, Pudong New Area, Shanghai Patentee after: Shanghai Sixin Pharmaceutical Technology Co.,Ltd. Address before: 235100 Qianlong Lake Industrial Park, Suixi Town, Huaibei City, Anhui Province Patentee before: HUAIBEI RUJIA MEDICAL TECHNOLOGY Co.,Ltd. |
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