CN103948705A - Antiallergy composition and its preparation method - Google Patents
Antiallergy composition and its preparation method Download PDFInfo
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- CN103948705A CN103948705A CN201410099921.8A CN201410099921A CN103948705A CN 103948705 A CN103948705 A CN 103948705A CN 201410099921 A CN201410099921 A CN 201410099921A CN 103948705 A CN103948705 A CN 103948705A
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Abstract
The invention discloses an antiallergy composition and its preparation method. The preparation method comprises the following steps: S1, boiling raspberry leaf weighed in parts by weight according to the ratio of raw material components with water for extraction, using macroporous resin column chromatography to treat an obtained filtrate, concentrating to obtain a thick pasty raspberry leaf extract; boiling bletilla striata weighed in parts by weight according to the ratio of raw material components with water for extraction, filtering, concentrating to obtain a thick pasty bletilla striata extract; and S2, evenly mixing the thick pasty raspberry leaf extract and the thick pasty bletilla striata extract obtained by step S1, adjusting the relative density to 1.1-1.25g/cm<3> to obtain the antiallergy composition. The antiallergy composition, namely raspberry essence is prepared by the preparation method, skin care products, health food or drugs using the antiallergy composition as a raw material can be taken orally and externally applied, are high in safety, can make the skin delicate while anti allergy, and can protect gastric mucosa when in oral administration.
Description
Technical field
The present invention relates to biological technical field, relate in particular to a kind of antiallergic composition of preparing taking stirrup cotyledon and the Pseudobulbus Bletillae (Rhizoma Bletillae) as raw material and the preparation method of said composition.
Background technology
Fructus Rubi corchorifolii Immaturus (Rubus Suavissimus S.Lee, popular name: Folium hydrangeae strigosae) is Rosaceae rubus perennial plant, it is Dayaoshan, Guangxi district endemic plant, cool in nature, nontoxic, Yin Qiye there is high sugariness composition and by among the people as health tea extensive use, be called Folium hydrangeae strigosae.Stirrup cotyledon main component is ellagitannic acid, sweetleaf Fructus Rubi corchorifolii Immaturus glycosides, flavone etc., and wherein ellagitannic acid has the effects such as remarkable antioxidation, antiallergic and antipruritic, convergence, anti-inflammation, restraint of tyrosinase activity, the generation of blocking-up melanin.The Pseudobulbus Bletillae (Rhizoma Bletillae) (Bletilla striata(Thunb.) Reichb.f.), be the tuber of the orchid Pseudobulbus Bletillae (Rhizoma Bletillae), main product Guizhou, Guangxi, Yunnan.
Summary of the invention
One of them object of the present invention is taking stirrup cotyledon and the Pseudobulbus Bletillae (Rhizoma Bletillae) as raw material, prepare a kind of antiallergic composition, said composition comprises Fructus Rubi corchorifolii Immaturus leaf extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract, and wherein material component and parts by weight thereof are respectively 10 parts of stirrup cotyledons, 0.5～10 part of the Pseudobulbus Bletillae (Rhizoma Bletillae).
Another object of the present invention is to provide a kind of and prepares the method for aforesaid antiallergic composition taking stirrup cotyledon and the Pseudobulbus Bletillae (Rhizoma Bletillae) as raw material, said method comprising the steps of:
S1, the stirrup cotyledon taking by material component and parts by weight thereof is carried out to decocting in water extraction, gained filtrate is carried out after macroporous resin column chromatography processing, concentrated, obtain described Fructus Rubi corchorifolii Immaturus leaf extract; The Pseudobulbus Bletillae (Rhizoma Bletillae) taking by material component and parts by weight thereof is carried out to decocting in water extraction, and filtering and concentrating, obtains described Pseudobulbus Bletillae (Rhizoma Bletillae) extract;
S2, the Fructus Rubi corchorifolii Immaturus leaf extract of gained in described step S1 and Pseudobulbus Bletillae (Rhizoma Bletillae) extract are evenly mixed, adjusting proportion is 1.1～1.25g/cm
3, obtain described antiallergic composition.
Preferably, described step S1 comprises: described stirrup cotyledon is carried out to decocting in water in multi-function extractor and extract twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, the merging of twice filtrate is let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add ethanol elution, collect eluent and remove after ethanol, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use; Or
Described stirrup cotyledon being carried out to decocting in water in multi-function extractor extracts twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, twice filtrate merging let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add methanol-eluted fractions, collect eluent and remove after methanol, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use; Or
Described stirrup cotyledon being carried out to decocting in water in multi-function extractor extracts twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, twice filtrate merging let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add acetone eluting, collect eluent and remove after acetone, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use.
Preferably, described step S1 comprises: the described Pseudobulbus Bletillae (Rhizoma Bletillae) is carried out to decocting in water in multi-function extractor and extract twice, each amount of water is 10～30 times of Pseudobulbus Bletillae (Rhizoma Bletillae) parts by weight, boil insulation 1.5 hours at every turn, filter, twice filtrate is merged, be concentrated into described Pseudobulbus Bletillae (Rhizoma Bletillae) extract for subsequent use.
Preferably, in described step S1, adopt D101 type macroporous adsorbent resin.
Bletilla glucomannan confirms to have the effects such as convergence, tonifying the lung, hemostasis, detumescence through modern study, can improve local blood circulation, promote epithelial cell reparation, energy hemostasis, sore, skin moistening and granulation promoting, Bletilla glucomannan has good skin-friendly in addition, character and arabic gum, tragacanth gum are similar, can be used as carrier, thickening agent, wetting agent etc.The present invention is based on ellagitannic acid in stirrup cotyledon and there is effect of antiallergic and antipruritic, utilizing Bletilla glucomannan (is the aforementioned Pseudobulbus Bletillae (Rhizoma Bletillae) extract obtaining, for thick paste shape) as pharmaceutical carrier, utilize the Pseudobulbus Bletillae (Rhizoma Bletillae) to improve local blood circulation simultaneously, promote epithelial cell reparation, can stop blooding, sore, the function of skin moistening and granulation promoting, the antiallergic composition that stirrup cotyledon and the Pseudobulbus Bletillae (Rhizoma Bletillae) are made according to preparation method provided by the invention, raw material by this antiallergic composition as cosmetics (or skin care item), when this cosmetics of external (or skin care item), not only antianaphylaxis function is better than with arabic gum, tragacanth gum is as pharmaceutical carrier, can also make skin exquisiteness simultaneously, raw material by this antiallergic composition as health food, medicine, this class health food for oral administration, medicine, safe, not only antiallergic, because the Bletilla glucomannan as pharmaceutical carrier is that extracted form natural plant obtains, takes orally and can protect gastric mucosa.
Brief description of the drawings
Fig. 1 is the preparation method flow chart of the antiallergic composition that provides of a kind of detailed description of the invention of the present invention.
Detailed description of the invention
Preferred embodiment the invention will be further described to contrast accompanying drawing combination below.
Embodiment 1
The stirrup cotyledon of 500kg is dropped into volume 6m
3in large multi-function extractor, about 5.5m adds water
3, boil insulation 1 hour, filter, filtering residue adds about 5.5m again
3water, boil insulation 1 hour, filter.After twice filtrate merging let cool, by macroporous resin adsorption, preferably can adopt 101 type macroporous resins, again with ethanol or methanol or acetone, the ethanol elution that is 60% with proportion in this embodiment, collect eluent and remove after ethanol, the concentrated about 150kg of Fructus Rubi corchorifolii Immaturus leaf extract that obtains thick paste shape, for subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae) of 50kg is dropped into volume 3m
3multi-function extractor in, add 1.5m
3water, boil insulation 1.5 hours, filter, filtering residue adds 1.5m again
3water, boil insulation 1.5 hours, filter.By twice concentrated about 150kg of Pseudobulbus Bletillae (Rhizoma Bletillae) extract that obtains thick paste shape of filtrate, mix homogeneously with the aforementioned approximately 150kg Fructus Rubi corchorifolii Immaturus leaf extract making, stir, reconcentration, adjusting proportion is 1.2g/cm
3, obtain a kind of antiallergic composition---Fructus Rubi corchorifolii Immaturus essence 150kg.This kind of antiallergic composition is taking stirrup cotyledon as primary raw material, utilize ellagitannic acid in stirrup cotyledon to there is antianaphylactic effect, be equipped with the Pseudobulbus Bletillae (Rhizoma Bletillae) as pharmaceutical carrier, the skin care item using said composition as raw material or cosmetics can also make skin exquisiteness the antianaphylactic while; Health food using said composition as raw material and medicine, not only safe while taking orally with antiallergic, and can also protect gastric mucosa, during outward in order to antiallergic, can also make skin exquisiteness.
Embodiment 2
The stirrup cotyledon of 500kg is dropped into volume 6m
3in large multi-function extractor, about 5.5m adds water
3, boil insulation 1 hour, filter, filtering residue adds about 5.5m again
3water, boil insulation 1 hour, filter.After twice filtrate merging let cool, by macroporous resin adsorption, preferably can adopt 101 type macroporous resins, with ethanol or methanol or acetone, in this embodiment, use 60% ethanol elution again, collect eluent and remove after ethanol, concentrate and obtain the about 150kg of Fructus Rubi corchorifolii Immaturus leaf extract, for subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae) of 100kg is dropped into volume 6m
3multi-function extractor in, add 3m
3water, boil insulation 1.5 hours, filter, filtering residue adds 3m again
3water, boil insulation 1.5 hours, filter.Twice filtrate concentrating obtained to the about 200kg of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, mix homogeneously with the aforementioned approximately 150kg Fructus Rubi corchorifolii Immaturus leaf extract making, stir, reconcentration, adjusting proportion is 1.15g/cm
3, obtain a kind of antiallergic composition-Fructus Rubi corchorifolii Immaturus essence 205kg.This kind of antiallergic composition is taking stirrup cotyledon as primary raw material, utilize ellagitannic acid in stirrup cotyledon to there is antianaphylactic effect, be equipped with the Pseudobulbus Bletillae (Rhizoma Bletillae) as pharmaceutical carrier, the skin care item using said composition as raw material or cosmetics can also make skin exquisiteness the antianaphylactic while; Health food using said composition as raw material and medicine, not only safe while taking orally with antiallergic, and can also protect gastric mucosa, during outward in order to antiallergic, can also make skin exquisiteness.
Embodiment 3
The stirrup cotyledon of 500kg is dropped into volume 8m
3in large multi-function extractor, about 7.5m adds water
3, boil insulation 1 hour, filter, filtering residue adds about 7.5m again
3water, boil insulation 1 hour, filter.After twice filtrate merging let cool, by macroporous resin adsorption, preferably can adopt 101 type macroporous resins, with ethanol or methanol or acetone, in this embodiment, use 60% ethanol elution again, collect eluent and remove after ethanol, concentrate and obtain the about 180kg of Fructus Rubi corchorifolii Immaturus leaf extract, for subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae) of 500kg is dropped into volume 6m
3multi-function extractor in, add 5m
3water, boil insulation 1.5 hours, filter, filtering residue adds 5m again
3water, boil insulation 1.5 hours, filter.Twice filtrate concentrating obtained to the about 600kg of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, mix homogeneously with the aforementioned approximately 180kg Fructus Rubi corchorifolii Immaturus leaf extract making, stir, reconcentration, adjusting proportion is 1.1g/cm
3, obtain a kind of antiallergic composition-Fructus Rubi corchorifolii Immaturus essence 650kg.This kind of antiallergic composition is taking stirrup cotyledon as primary raw material, utilize ellagitannic acid in stirrup cotyledon to there is antianaphylactic effect, be equipped with the Pseudobulbus Bletillae (Rhizoma Bletillae) as pharmaceutical carrier, the skin care item using said composition as raw material or cosmetics can also make skin exquisiteness the antianaphylactic while; Health food using said composition as raw material and medicine, not only safe while taking orally with antiallergic, and can also protect gastric mucosa, during outward in order to antiallergic, can also make skin exquisiteness.
Embodiment 4
The stirrup cotyledon of 500kg is dropped into volume 6m
3in large multi-function extractor, about 5m adds water
3, boil insulation 1 hour, filter, filtering residue adds about 5m again
3water, boil insulation 1 hour, filter.After twice filtrate merging let cool, by macroporous resin adsorption, preferably can adopt 101 type macroporous resins, with ethanol or methanol or acetone, in this embodiment, use 60% ethanol elution again, collect eluent and remove after ethanol, concentrate and obtain the about 150kg of Fructus Rubi corchorifolii Immaturus leaf extract, for subsequent use; The Pseudobulbus Bletillae (Rhizoma Bletillae) of 25kg is dropped into volume 1m
3multi-function extractor in, add 0.5m
3water, boil insulation 1.5 hours, filter, filtering residue adds 0.5m again
3water, boil insulation 1.5 hours, filter.Twice filtrate concentrating obtained to the about 50kg of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, mix homogeneously with the aforementioned approximately 150kg Fructus Rubi corchorifolii Immaturus leaf extract making, stir, reconcentration, adjusting proportion is 1.25g/cm
3, obtain a kind of antiallergic composition-Fructus Rubi corchorifolii Immaturus essence 140kg.This kind of antiallergic composition is taking stirrup cotyledon as primary raw material, utilize ellagitannic acid in stirrup cotyledon to there is antianaphylactic effect, be equipped with the Pseudobulbus Bletillae (Rhizoma Bletillae) as pharmaceutical carrier, the skin care item using said composition as raw material or cosmetics can also make skin exquisiteness the antianaphylactic while; Health food using said composition as raw material and medicine, not only safe while taking orally with antiallergic, and can also protect gastric mucosa, during outward in order to antiallergic, can also make skin exquisiteness.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For those skilled in the art, without departing from the inventive concept of the premise, can also make some being equal to substitute or obvious modification, and performance or purposes identical, all should be considered as belonging to protection scope of the present invention.
Claims (5)
1. an antiallergic composition, is characterized in that: comprise Fructus Rubi corchorifolii Immaturus leaf extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract, material component and parts by weight thereof are respectively: 10 parts of stirrup cotyledons, 0.5～10 part of the Pseudobulbus Bletillae (Rhizoma Bletillae).
2. the preparation method of antiallergic composition as claimed in claim 1, is characterized in that, comprises the following steps:
S1, the stirrup cotyledon taking by material component and parts by weight thereof is carried out to decocting in water extraction, gained filtrate is carried out after macroporous resin column chromatography processing, concentrated, obtain described Fructus Rubi corchorifolii Immaturus leaf extract; The Pseudobulbus Bletillae (Rhizoma Bletillae) taking by material component and parts by weight thereof is carried out to decocting in water extraction, and filtering and concentrating, obtains described Pseudobulbus Bletillae (Rhizoma Bletillae) extract;
S2, the Fructus Rubi corchorifolii Immaturus leaf extract of gained in described step S1 and Pseudobulbus Bletillae (Rhizoma Bletillae) extract are evenly mixed, adjusting proportion is 1.1～1.25g/cm
3, obtain described antiallergic composition.
3. preparation method as claimed in claim 2, is characterized in that, described step S1 comprises:
Described stirrup cotyledon being carried out to decocting in water in multi-function extractor extracts twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, twice filtrate merging let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add ethanol elution, collect eluent and remove after ethanol, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use; Or
Described stirrup cotyledon being carried out to decocting in water in multi-function extractor extracts twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, twice filtrate merging let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add methanol-eluted fractions, collect eluent and remove after methanol, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use; Or
Described stirrup cotyledon being carried out to decocting in water in multi-function extractor extracts twice, each amount of water is 10～15 times of stirrup cotyledon parts by weight, boil rear insulation 1 hour at every turn, after filtration, twice filtrate merging let cool, filtrate is carried out to adsorption treatment with macroporous adsorbent resin, add acetone eluting, collect eluent and remove after acetone, be concentrated into described Fructus Rubi corchorifolii Immaturus leaf extract for subsequent use.
4. preparation method as claimed in claim 2 or claim 3, is characterized in that, described step S1 comprises:
The described Pseudobulbus Bletillae (Rhizoma Bletillae) is carried out to decocting in water in multi-function extractor and extract twice, each amount of water is 10～30 times of Pseudobulbus Bletillae (Rhizoma Bletillae) parts by weight, boils insulation 1.5 hours at every turn, filters, and twice filtrate is merged, and is concentrated into described Pseudobulbus Bletillae (Rhizoma Bletillae) extract for subsequent use.
5. preparation method as claimed in claim 2, is characterized in that: in described step S1, adopt 101 type macroporous adsorbent resins.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410099921.8A CN103948705A (en) | 2014-03-18 | 2014-03-18 | Antiallergy composition and its preparation method |
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| CN201410099921.8A CN103948705A (en) | 2014-03-18 | 2014-03-18 | Antiallergy composition and its preparation method |
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| CN103948705A true CN103948705A (en) | 2014-07-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653090A (en) * | 2018-07-01 | 2018-10-16 | 佛山市芊茹化妆品有限公司 | A kind of antiallergic composition |
| CN109364130A (en) * | 2018-12-12 | 2019-02-22 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | A kind of spina gleditsiae adulterant is preparing the application in antioxidant |
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| CN102028774A (en) * | 2010-12-02 | 2011-04-27 | 南宁圣特生物科技有限公司 | Antiallergic raspberry composite product and preparation method thereof |
| CN102600364A (en) * | 2012-03-15 | 2012-07-25 | 沈慰平 | Application of bletilla to preparation of medicine for allergic skin treatment, burnt wound restoration and tissue and skin regeneration promotion |
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2014
- 2014-03-18 CN CN201410099921.8A patent/CN103948705A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028774A (en) * | 2010-12-02 | 2011-04-27 | 南宁圣特生物科技有限公司 | Antiallergic raspberry composite product and preparation method thereof |
| CN102600364A (en) * | 2012-03-15 | 2012-07-25 | 沈慰平 | Application of bletilla to preparation of medicine for allergic skin treatment, burnt wound restoration and tissue and skin regeneration promotion |
Non-Patent Citations (2)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653090A (en) * | 2018-07-01 | 2018-10-16 | 佛山市芊茹化妆品有限公司 | A kind of antiallergic composition |
| CN109364130A (en) * | 2018-12-12 | 2019-02-22 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | A kind of spina gleditsiae adulterant is preparing the application in antioxidant |
| CN109364130B (en) * | 2018-12-12 | 2021-11-09 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | Application of spina gleditsiae counterfeit product in preparation of antioxidant |
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Application publication date: 20140730 |