CN103948629A - Preparation method for corn cervi pantotrichum extract - Google Patents
Preparation method for corn cervi pantotrichum extract Download PDFInfo
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- CN103948629A CN103948629A CN201410180936.7A CN201410180936A CN103948629A CN 103948629 A CN103948629 A CN 103948629A CN 201410180936 A CN201410180936 A CN 201410180936A CN 103948629 A CN103948629 A CN 103948629A
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Abstract
The invention discloses a preparation method for a corn cervi pantotrichum extract. The preparation method comprises the following steps of: (1) cleaning, chopping, soaking, decocting and filtering corn cervi pantotrichum to obtain a corn cervi pantotrichum solution A; collecting corn cervi pantotrichum residues; (2) carrying out atmospheric distillation on the corn cervi pantotrichum solution A, and collecting distillate B; cooling the distillate B, standing and then carrying out hot-press distillation, and collecting distillate C; (3) adding ethanol in the corn cervi pantotrichum residues obtained by collecting in the step (1), and carrying out heating reflux extraction for 3-5 times, keeping a boiling state for 1-2 hours every time, combining the extracts, recovering ethanol, cooling to an environmental temperature, and collecting reflux liquid D; (4) mixing the distillate C with the reflux liquid D, and carrying out hot-press distillation again to obtain distillate F; (5) treating, sterilizing and filling the obtained distillate F by ion exchange resin to obtain the corn cervi pantotrichum extract. According to the preparation method disclosed by the invention, effective ingredients in corn cervi pantotrichum are furthest extracted, corn cervi pantotrichum raw material resources are adequately utilized, the process is moderate, and the damages to the effective ingredients are reduced.
Description
Technical field
The present invention relates to a kind of preparation method of Cornu Cervi Pantotrichum extractum.
Background technology
Cornu Cervi Pantotrichum, when the tender angle of stag does not grow up to os osseum, band fine hair, containing blood, is a kind of Chinese medicine, because former animal is different, is divided into two kinds of pilose antler of sika (yellow young pilose antler) and cervus elaphus linnaeuss (QINGMAO is fine and soft); Due to the difference of collecting method be divided into again cut fine and soft with crouch fine and soft two kinds; Because branch is how many and old tender difference, can be divided into again saddle, two thick sticks, Gua Jiao, three troubles, that flower is cut young pilose antler, Flos Nelumbinis etc. is multiple.Cornu Cervi Pantotrichum is as tonic invigorator, and effective in cure to weakness, neurasthenia etc., " Sheng Nong's herbal classic " classifies middle product as.
At present, Cornu Cervi Pantotrichum is mainly to extract its active ingredient by the mode of steaming and decocting.Although traditional boiling method is simple to operate, its productive rate is limited, and the inside plurality of active ingredients can not be fully utilized, and causes the waste of raw material.
Also do not find in the market Cornu Cervi Pantotrichum extractum.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method of Cornu Cervi Pantotrichum extractum, by Cornu Cervi Pantotrichum is soaked, decocts, and slag liquid is separated, air-distillation, and hot pressing distillation, the steps such as reflux, extract, are prepared Cornu Cervi Pantotrichum extractum, improve the drug effect of Cornu Cervi Pantotrichum.
Particularly, the preparation method of Cornu Cervi Pantotrichum extractum is as follows:
A preparation method for Cornu Cervi Pantotrichum extractum, is characterized in that comprising the following steps:
(1) Cornu Cervi Pantotrichum is cleaned, shredded, soak 10-15min, decoct 30-60min, filter, obtain antler liquid A; Collect Cornu Cervi Pantotrichum slag;
(2) antler liquid A is carried out to air-distillation, collect distillate B; Distillate B is cooling, carry out hot pressing distillation after standing, collect distillate C;
(3) to step (1), collecting the Cornu Cervi Pantotrichum slag obtaining adds the alcohol heating reflux that its weight 8-10 mass concentration is doubly 40-60% to extract 3-5 time, each fluidized state 1-2 hour that keeps, merge extractive liquid,, reclaims ethanol, be cooled to ambient temperature, collect backflow D;
(4) distillate C and backflow D mixed and again carry out hot pressing distillation, obtaining distillate F;
(5) spent ion exchange resin is processed to the distillate F of gained, sterilizing, fill, obtains Cornu Cervi Pantotrichum extractum.
In above-mentioned steps (2), the air-distillation of distillate A is carried out three times continuously, the vapo(u)rizing temperature of three times is respectively 105-110 ℃, 113-115 ℃, and 120-123 ℃, the time of each distillation is 20-30min; Hot pressing distillation to distillate B is carried out three times continuously, and vapo(u)rizing temperature is respectively 125-130 ℃, 133-135 ℃, and 140-143 ℃, the time of each distillation is 20-30min, the pressure of hot pressing distillation is 0.15-0.18Mpa.
In above-mentioned steps (4), the temperature of hot pressing distillation is 133-135 ℃, and the time of distillation is 20-30min, and the pressure of hot pressing distillation is 0.15-0.18Mpa.
Beneficial effect of the present invention is:
1, by adopting, Cornu Cervi Pantotrichum is soaked, decoct, slag liquid is separated and slag liquid is carried out respectively to the method for reflux, extract,, distillation, farthest extracts the effective ingredient in Cornu Cervi Pantotrichum, makes full use of Cornu Cervi Pantotrichum raw material resources.
2, in still-process, take the distillating method of the segmentation temperature difference, guaranteed the extraction ratio to effective constituent of pilose antler, process is gentle, has reduced the destruction to effective ingredient.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiment.
Embodiment 1
A preparation method for Cornu Cervi Pantotrichum extractum, comprises the steps:
(1) Cornu Cervi Pantotrichum is cleaned, shredded, soak 10min, decoct 60min, filter, obtain antler liquid A; Collect Cornu Cervi Pantotrichum slag;
(2) distillate A is carried out to three air-distillations continuously, the vapo(u)rizing temperature of three times is respectively 105 ℃, and 113 ℃, 120 ℃, the time of each distillation is 30min, collects distillate B; Distillate B is cooling, standing rear three the hot pressing distillation of carrying out continuously, vapo(u)rizing temperature is respectively 125 ℃, and 133 ℃, 140 ℃, the time of each distillation is 30min, and the pressure of hot pressing distillation is 0.18Mpa, collects distillate C;
(3) to step (1), collect the Cornu Cervi Pantotrichum slag obtaining and add the alcohol heating reflux that the mass concentration of 8 times of its weight is 40% to extract 3 times, keep fluidized state 1 hour at every turn, merge extractive liquid,, reclaims ethanol, is cooled to ambient temperature, collects backflow D;
(4) distillate C and backflow D are mixed and again carry out hot pressing distillation, the temperature of hot pressing distillation is 133 ℃, and the time of distillation is 30min, and the pressure of hot pressing distillation is 0.18Mpa, obtains distillate F;
(5) spent ion exchange resin is processed to the distillate F of gained, sterilizing, fill, obtains Cornu Cervi Pantotrichum extractum.
Embodiment 2
A preparation method for Cornu Cervi Pantotrichum extractum, comprises the steps:
(1) Cornu Cervi Pantotrichum is cleaned, shredded, soak 13min, decoct 50min, filter, obtain antler liquid A; Collect Cornu Cervi Pantotrichum slag;
(2) distillate A is carried out to three air-distillations continuously, the vapo(u)rizing temperature of three times is respectively 107 ℃, and 114 ℃, 122 ℃, the time of each distillation is 25min, collects distillate B; Distillate B is cooling, standing rear three the hot pressing distillation of carrying out continuously, vapo(u)rizing temperature is respectively 128 ℃, and 134 ℃, 141 ℃, the time of each distillation is 25min, and the pressure of hot pressing distillation is 0.17Mpa, collects distillate C;
(3) to step (1), collect the Cornu Cervi Pantotrichum slag obtaining and add the alcohol heating reflux that the mass concentration of 9 times of its weight is 50% to extract 4 times, keep fluidized state 1.5 hours at every turn, merge extractive liquid,, reclaims ethanol, is cooled to ambient temperature, collects backflow D;
(4) distillate C and backflow D are mixed and again carry out hot pressing distillation, the temperature of hot pressing distillation is 134 ℃, and the time of distillation is 25min, and the pressure of hot pressing distillation is 0.16Mpa, obtains distillate F;
(5) spent ion exchange resin is processed to the distillate F of gained, sterilizing, fill, obtains Cornu Cervi Pantotrichum extractum.
Embodiment 3
A preparation method for Cornu Cervi Pantotrichum extractum, comprises the steps:
(1) Cornu Cervi Pantotrichum is cleaned, shredded, soak 15min, decoct 30min, filter, obtain antler liquid A; Collect Cornu Cervi Pantotrichum slag;
(2) distillate A is carried out to three air-distillations continuously, the vapo(u)rizing temperature of three times is respectively 110 ℃, and 115 ℃, 1123 ℃, the time of each distillation is 20min, collects distillate B; Distillate B is cooling, standing rear three the hot pressing distillation of carrying out continuously, vapo(u)rizing temperature is respectively 130 ℃, and 135 ℃, 143 ℃, the time of each distillation is 20min, and the pressure of hot pressing distillation is 0.15Mpa, collects distillate C;
(3) to step (1), collecting the Cornu Cervi Pantotrichum slag obtaining adds the alcohol heating reflux that the mass concentration of 10 times of its weight is 40-60% to extract 5 times, each maintenance fluidized state 2 hours, merge extractive liquid,, reclaims ethanol, be cooled to ambient temperature, collect backflow D;
(4) distillate C and backflow D are mixed and again carry out hot pressing distillation, the temperature of hot pressing distillation is 135 ℃, and the time of distillation is 20min, and the pressure of hot pressing distillation is 0.15Mpa, obtains distillate F;
(5) spent ion exchange resin is processed to the distillate F of gained, sterilizing, fill, obtains Cornu Cervi Pantotrichum extractum.
Claims (3)
1. a preparation method for Cornu Cervi Pantotrichum extractum, is characterized in that, preparation technology is as follows:
(1) Cornu Cervi Pantotrichum is cleaned, shredded, soak 10-15min, decoct 30-60min, filter, obtain antler liquid A; Collect Cornu Cervi Pantotrichum slag;
(2) antler liquid A is carried out to air-distillation, collect distillate B; Distillate B is cooling, carry out hot pressing distillation after standing, collect distillate C;
(3) to step (1), collecting the Cornu Cervi Pantotrichum slag obtaining adds the alcohol heating reflux that its weight 8-10 mass concentration is doubly 40-60% to extract 3-5 time, each fluidized state 1-2 hour that keeps, merge extractive liquid,, reclaims ethanol, be cooled to ambient temperature, collect backflow D;
(4) distillate C and backflow D mixed and again carry out hot pressing distillation, obtaining distillate F;
(5) spent ion exchange resin is processed to the distillate F of gained, sterilizing, fill, obtains Cornu Cervi Pantotrichum extractum.
2. the preparation method of Cornu Cervi Pantotrichum extractum according to claim 1, it is characterized in that: in described step (2), the air-distillation of distillate A is carried out three times continuously, the vapo(u)rizing temperature of three times is respectively 105-110 ℃, 113-115 ℃, 120-123 ℃, the time of each distillation is 20-30min; Hot pressing distillation to distillate B is carried out three times continuously, and vapo(u)rizing temperature is respectively 125-130 ℃, 133-135 ℃, and 140-143 ℃, the time of each distillation is 20-30min, the pressure of hot pressing distillation is 0.15-0.18Mpa.
3. the preparation method of Cornu Cervi Pantotrichum extractum according to claim 1, is characterized in that: in described step (4), the temperature of hot pressing distillation is 133-135 ℃, and the time of distillation is 20-30min, and the pressure of hot pressing distillation is 0.15-0.18Mpa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410180936.7A CN103948629A (en) | 2014-04-30 | 2014-04-30 | Preparation method for corn cervi pantotrichum extract |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078890A (en) * | 1993-04-07 | 1993-12-01 | 辽宁省西丰中药厂 | The prescription of fresh pilose antler liquid and bright fine and soft oral liquid and preparation method |
| CN1430971A (en) * | 2002-01-11 | 2003-07-23 | 郑彬 | Method for lixiviating effective constituent of pilose antler in low temp. and ultrasonic cracking |
| CN1481814A (en) * | 2003-07-24 | 2004-03-17 | 白秀娟 | Method of extracting alcohol-soluble freeze-dry antler extract product |
| CN103271401A (en) * | 2013-05-30 | 2013-09-04 | 湖北午时药业股份有限公司 | Preparation method of honeysuckle flower distillate |
-
2014
- 2014-04-30 CN CN201410180936.7A patent/CN103948629A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078890A (en) * | 1993-04-07 | 1993-12-01 | 辽宁省西丰中药厂 | The prescription of fresh pilose antler liquid and bright fine and soft oral liquid and preparation method |
| CN1430971A (en) * | 2002-01-11 | 2003-07-23 | 郑彬 | Method for lixiviating effective constituent of pilose antler in low temp. and ultrasonic cracking |
| CN1481814A (en) * | 2003-07-24 | 2004-03-17 | 白秀娟 | Method of extracting alcohol-soluble freeze-dry antler extract product |
| CN103271401A (en) * | 2013-05-30 | 2013-09-04 | 湖北午时药业股份有限公司 | Preparation method of honeysuckle flower distillate |
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Application publication date: 20140730 |