CN103933157A

CN103933157A - Preparation method of spraying-coating agent for treating and preventing fatty liver

Info

Publication number: CN103933157A
Application number: CN201410157162.6A
Authority: CN
Inventors: 杨军
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-20
Filing date: 2014-04-20
Publication date: 2014-07-23

Abstract

The invention discloses a preparation method of a spraying-coating agent for treating and preventing fatty liver. A principle of treating an internal illness by external treatment of traditional Chinese medicine is adopted, table vinegar is used as a penetration enhancer and combined with traditional Chinese medicines for treating liver, and modern ultrasonic extraction and membrane separation technologies are applied for preparation; a small amount of the medicine is closely administrated on the skin part of the liver through the skin, and can be absorbed with massage additionally, thus greatly reducing discomfort and side effects brought to the intestines and stomach due to medicine administration; the medicine permeates to the focus part under the resistance of vinegar, thus achieving the purpose of locally administrating to realize targeted therapy on diseases; the patients achieve the purposes of resolving dampness and clearing heat, soothing liver and regulating qi, promoting blood circulation and removing blood stasis, and relieve swelling and pain, and the spraying-coating agent is non-toxic and free from side effects, safe and reliable, simple to use, convenient to administrate, painless, non-residue, and capable of being accepted and used by the majority of patients with pleasure.

Description

A kind of preparation method of Prevention fatty liver spraying liniment

Technical field

The present invention relates to a kind of processing of external spraying liniment, particularly make a kind of preparation method of Prevention fatty liver Chinese medicine composition spraying liniment, belong to processing technique of Chinese herbs field.

Background technology

China people people life level generally improves, and causes athero in a lot of people's body weight increase, body obesity, hepatocyte, and fatty liver becomes one disease comparatively common in current modern disease, and it seriously affects the health of people's health.Patients with Fatty Liver has that diet is depressed, weak, nauseating, the symptom of abdominal distention, diarrhoea, dull pain in liver.Also there will be the Signs of similar chronic hepatitis, as abnormal liver function, the diseases such as uncomfortable liver area.Chinese medicine and the Western medicine for the treatment of fatty liver have much at present, and Long-term taking medicine can bring degenerative and drug resistance to patient body, make health produce untoward reaction, also can form dependency to medicine.

Chinese medicine inner disease outer therapy is one of therapy the most valuable in motherland's medical science, and medicine slowly infiltrates into pathogenic factor, reach eliminating evil and just do not hinder, and righting and do not stay heresy, thus reach the object of cure diseases.Adopt the percutaneous osmotic absorption of liver disease drug, skin expansion capillary permeability, improves local and overall metabolic function, strengthens blood flow, improves microcirculation, lowers blood fat, improves liver function, repairs hepatic injury, improves fatty liver distending pain.Also improve patient's body's immunity, finally reach the object of curing fatty liver simultaneously.

Compendium of Material Medica is recorded, and vinegar energy " dissipating blood stasis blood, the subcutaneous ulcer of harnessing the Yellow River, yellowish perspiration " can " whet the appetite, nourishing the liver "." Chinese medicine voluminous dictionary " is also documented coordinating other drug to treat acute and chronic infectious hepatitis with vinegar.As just proposed in " element is to declaring five gas sections ": " five tastes enter, sour in taste acting on the liver, pungent in taste acting on the lung, bitter in taste acting on the heart, salty flavor entering the kidney, sweet flavour enters the spleen " is also one of theoretical foundation forming afterwards Meridian Tropism of Herbal Drugs theory.Vinegar has good health-care effect to liver, people's edible alkaline meat food in a large number in the modern life, and vinegar is conducive to acid-base neutralization, can prevent hyperlipidemia, arteriosclerosis, fatty liver etc.

Modern scientific research confirms the compounds such as acetic acid, lactic acid, aminoacid, glycerol and the aldehyde in vinegar, and skin is had to soft stimulation, makes little vasodilation, increases the blood circulation of skin, and sour environment contributes to medicine transdermal.Vinegar is mainly to expand and soften cuticle, thereby can make the large medicine ion that is conducive to of opening change of sweat gland, hair follicle, by skin, skin be played to softening, soft assistance infiltration.Make its structural arrangement disorder by acting on skin lipoid interstitial, thereby destroy permeability, the Transdermal absorption of medicine is increased, vinegar can also play bactericidal antiphlogistic effect to skin.

Summary of the invention

The object of the invention is to provide for Patients with Fatty Liver a kind of preparation method of Prevention fatty liver external spraying liniment, this invention adopts the principle of inner disease outer treat in theory of Chinese medical science, combine with the plurality of Chinese for the treatment of liver tablet vinegar as penetration enhancer, use modern ultrasonic extraction and membrane separation technique, be prepared into a kind of spraying liniment of safe treatment fatty liver external treatment.

In order to achieve the above object, the present invention realizes by following technological means, first the Chinese medicine for the treatment of hepatopathy is pulverized, using vinegar as extracting solvent, utilize the sharp pounding of ultrasound wave generation, higher speed, fierce cavitation effect and stirring action acceleration effective ingredient to be dissolved in solvent, dissolve the most of Organic substance of Chinese medicine and inorganic matter.Adopt ultrasonic extraction energy-conserving and environment-protective, in leaching process, without chemical reaction, the bioactive substance being extracted remains unchanged at short notice, has shortened extraction time, has also improved extraction efficiency.

Adopt micro-filtration membrane isolation technics to carry out clarifying treatment to extracting solution, under fluid pressure action, micro-filtration membrane is held back molecule, antibacterial and macromolecular substances, makes the micromolecule such as saccharide, alkaloid, organic acid, water see through filter membrane.Insoluble substance is held back in the use of micro-filtration membrane, can obtain transparent limpid aseptic spraying baste.Make medicine be penetrated into lesions position under the help of vinegar, reach the object of topical targeted therapy disease.

Tablet vinegar is that grain fermentation forms, and is the daily seasoning good merchantable brands of people.Main component is that acetic acid also contains the nutritional labelings such as each seed amino acid, organic acid, saccharide, vitamin, alcohol and ester, and contained aminoacid in tablet vinegar, not only can decompose body fat, carries out smoothly but also can promote that saccharide, protein etc. are metabolic.Threonine in the aminoacid of needed by human body and methionine can reduce fat; prevent the accumulation of fat in liver; the generation that harmful substance in body is removed to enhancing antibody as heavy metals such as lead; can play a very good protection to liver, effectively prevent the generation of fatty liver and liver function disease.

Vinegar contains volatile material and aminoacid etc., can stimulate cerebral nerve maincenter, makes digestive organs secrete a large amount of Digestive systems, strengthens digestive function.Life-time service vinegar is very safely to healthy also very useful.Tablet vinegar as hepatopathy Chinese medicine penetration enhancer have short thoroughly, treatment, the multiple action such as fragrant, anticorrosion.Alkaloid in vinegar and Chinese medicine is transformed into salt, easier water-soluble infiltration.Using tablet vinegar as extracting solvent, compare with the Percutaneous absorption enhancer of combination drug, pointed strong, with low cost, effect is guaranteed significantly again the advantage of medicine for external use safety.

Compared with prior art, treatment and prevention fatty liver are smeared in external spraying provided by the invention, only medicine closely need be seen through to skin liver skin part is carried out to a small amount of administration, add that massaging gently a few minutes just can absorb, greatly reduce bring to the intestines and stomach because taking medicine do not accommodate side effect.Thereby make patient reach the object of removing dampness heat clearing away, depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For Patients with Fatty Liver provides a kind of manufacture method of Chinese medicine class inner disease outer treat medicament of novelty, its no side effects, safe and reliable, use simple, convenient drug administration, no pain, noresidue, extensive patients is all taken like a shot and is used.

Detailed description of the invention

1. raw material by weight takes; 15～20 parts of Herba Artemisiae Scopariaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of long-pending realities, 15～20 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 20～25 parts of Fructus Crataegis, 3～6 parts, Flos Carthami, send in disintegrating machine and carry out fragmentation, is broken into the granule of 3mm～5mm size.

2. the Chinese medicine of pulverizing is sent in ultrasonic extraction tank, added the tablet vinegar of 2 times of pulverizing Chinese medicine weight, soaking 6h～8h. intensified by ultrasonic wave extraction equipment power is 200W, extracts temperature and is controlled at 45 DEG C～65 DEG C, and extraction time is 15min～25min.

3. with centrifugal separator, drug solns is carried out to medicinal liquid and separate with medicinal residues, centrifugal separator rotating speed is controlled at 3000～4500 turn/min, removes float and medicinal residues, separates and obtains without slag medicinal liquid.

4. the medicinal liquid after separating adopts external-compression type tubular filter to carry out microfiltration again, and microfiltration is selected the microporous filter membrane of aperture at 0.2 μ m～0.6 μ m, and filter pressure is 0.05 MPa～0.5MPa, carries out microfiltration at flow velocity 1.0～3.5m/s.

5. the spray coating liquor that obtains clarification through microfiltration is filled to spray coating liquor capping in spray bottle in gnotobasis, prints date of manufacture packaging cartonning.

The spray result of liniment treatment fatty liver of the present invention;

Therapeutic Method:

Be liver position skin spray liniment to right side of body intercostal every day, and spraying is smeared 3～6 times, rub 2～3 minutes in conjunction with part massage, and within one month, be a course for the treatment of, continuous 6 courses for the treatment of.Coordinate alleviating alcohol addiction, mood is optimistic, rational diet, appropriate exercise.

Efficacy evaluation:

Cure: B ultrasonic shows that fatty liver disappears, and rate and blood-lipid decreased is to normal range, transference cure.

Take a turn for the better: liver function test index is normal, the symptom anesthesia of dull pain in liver, symptom takes a turn for the better.

Invalid: have abnormal liver function, the symptom of uncomfortable liver area, does not reach the standard person of improvement, and symptom is without alleviating.

Model case:

Huang, man, 37 years old, liver function test: glutamate pyruvate transaminase (ALT) 72U/L, glutamic oxaloacetic transaminase, GOT 40U/L, glutamyl transpeptidase 55U/L, cholesterol 5.22mmol/l, triglyceride 5.0mmol/L, ultrasound diagnosis is severe fatty liver.Use medicine of the present invention, 3 courses for the treatment of of external curing, all diseases alleviate, and weight loss continues to use 2 courses for the treatment of, and check liver function, blood fat are all normal, follow up a case by regular visits to without recurrence after half a year.

Zhu, female, 45 years old, right flank dull pain discomfort, bitter taste that appetite is not good enough.Once do the inspections such as liver function, blood fat, color ultrasound, CT, be diagnosed as fatty liver.Blood fat is higher, and transaminase is high.Examine and see red tongue with yellowish and greasy fur, slippery and rapid pulse.Use medicine of the present invention, smear every day 4～6 times, after 2 courses for the treatment of, all diseases alleviate, and continue to use 4 courses for the treatment of.Check liver function, blood fat is all normal, ultrasound diagnosis: liver and gall spleen pancreas shows no obvious abnormalities, recovery from illness.After half a year, follow up a case by regular visits to without recurrence.

Sum up curative effect:

In above-mentioned treatment: smear in the routine patient for the treatment of Patients with Fatty Liver 38 with medicine external spraying of the present invention, cure 18 examples (47.8%), 17 examples that take a turn for the better (44.7%), invalid 3 examples (7.8%), total effective rate is 92.2%.

Claims

1. a preparation method for Prevention fatty liver spraying liniment, is characterized in that completing through following steps:

(1) raw material by weight takes; 15～20 parts of Herba Artemisiae Scopariaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of long-pending realities, 15～20 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 20～25 parts of Fructus Crataegis, 3～6 parts, Flos Carthami, send in disintegrating machine and carry out fragmentation, is broken into the granule of 3mm～5mm size;

(2) Chinese medicine of pulverizing is sent in ultrasonic extraction tank, added the tablet vinegar of 2 times of pulverizing Chinese medicine weight, soaking 6h～8h. intensified by ultrasonic wave extraction equipment power is 200W, extracts temperature and is controlled at 45 DEG C～65 DEG C, and extraction time is 15min～25min;

(3) with centrifugal separator, drug solns is carried out to medicinal liquid and separate with medicinal residues, centrifugal separator rotating speed is controlled at 3000～4500 turn/min, removes float and medicinal residues, separates and obtains without slag medicinal liquid;

(4) medicinal liquid after separation adopts external-compression type tubular filter to carry out microfiltration again, and microfiltration is selected the microporous filter membrane of aperture at 0.2 μ m～0.6 μ m, and filter pressure is 0.05 MPa～0.5MPa, carries out microfiltration at flow velocity 1.0～3.5m/s;

(5) obtain through microfiltration the spray coating liquor of clarifying, spray coating liquor is filled to capping in spray bottle in gnotobasis, print date of manufacture packaging cartonning.

2. the preparation method of a kind of Prevention fatty liver spraying liniment according to claim 1, is characterized in that: 55 DEG C of intensified by ultrasonic wave extraction optimum temperatures, the optimum extraction time is 20min.

3. the preparation method of a kind of Prevention fatty liver spraying liniment according to claim 1, is characterized in that: it is the microporous filter membrane of 0.5 μ m that microfiltration is selected aperture, and filter pressure is 0.3MPa.

4. the preparation method of a kind of Prevention fatty liver spraying liniment according to claim 1, it is characterized in that: best Chinese medicine composition is 15 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 15 parts of Radix Salviae Miltiorrhizaes, long-pending real 10 parts, 15 parts of Radix Angelicae Sinensis, 10 parts of the Radix Paeoniae Albas, 20 parts of Fructus Crataegis, 5 parts, Flos Carthami.