CN103926238A - Portable multipurpose chemiluminescence imager - Google Patents
Portable multipurpose chemiluminescence imager Download PDFInfo
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- CN103926238A CN103926238A CN201310013267.XA CN201310013267A CN103926238A CN 103926238 A CN103926238 A CN 103926238A CN 201310013267 A CN201310013267 A CN 201310013267A CN 103926238 A CN103926238 A CN 103926238A
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Abstract
The invention discloses an imager for detection of a chemiluminescence signal. The imager includes an outer shell module, a front cover light-shielding module, a circuit module, a CCD lens assembly, a focusing positioning frame module, an inner shell light-shielding structure module, a chip and other detection target-bearing platform module, and a sliding moving module; the front cover light-shielding module is fixedly connected with the chip and other detection target-bearing platform module; the circuit module is fixed in the outer shell module; the CCD lens assembly is fixed on the focusing positioning frame module; the focusing positioning frame module is fixedly connected on the inner shell light-shielding structure module; the inner shell light-shielding structure module is fixed in the outer shell module; a biochip and other detection targets are positioned and placed on the chip and other detection target-bearing platform module; a chip and other detection target-bearing platform is fixed on the sliding moving module. The imager has the advantages of adjustable focal distance, short image analysis time, portable full-set device and the like, and is in favor of promoting applications of the biochip, immune percolation, immune chromatography and other technologies in disease diagnosis and drug development.
Description
Technical field
The present invention relates to a kind of portable multi-purpose chemiluminescence imager in chemiluminescence detection technical field, belong to field of biomedicine technology.
Background technology
Biochip finger protein biochip and gene biological chip etc.Because thering is high flux, robotization, microminiaturization, high sensitivity, multiparameter Synchronization Analysis, traditional incomparable advantage of detection method such as quick, has been widely used in the fields such as gene studies, drug research, medical diagnosis on disease.
At present the input of biochip is mostly based on fluorescence method, its instrument complicated integral structure, and dependence on import, expensive, seriously limited the promotion and application of biochip.Under this background, the biochip new technical platform with independent intellectual property right that patent utilization of the present invention has been set up, give full play to this technology platform high flux, high-sensitive advantage, develop based on chemiluminescent a kind of portable multi-purpose chemiluminescence biochip imaging instrument.
Summary of the invention
Object of the present invention be intended to overcome the deficiencies in the prior art and provide a kind of analyzing biochips highly sensitive, contain much information, the graphical analysis time is short, can obtain complete chip array image, simple in structure, cost is low, the Novel biological chip analyser that performance is good.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of portable multi-purpose chemiluminescence imager, comprises that shell module, the worn-out optical module of protecgulum, circuit module, CCD lens assembly, focusing locating rack module, the worn-out photo structure module of inner casing, chip etc. detect target carrying platform module, sliding module;
Described shell module, encapsulates whole instrument parts, and internally environment carries out preliminary worn-out light, and upper end is provided with handle, is connected with bottom screw, is convenient to integral body and carries;
The worn-out optical module of described protecgulum, for the detection target carrying platform module shift-in housings such as described chip provide worn-out light trap lid, the detection target plummer such as built-in attacker's convenient operation person push-and-pull chip it on;
Described circuit module, for described CCD lens assembly provides power, for there being CCD assembly under power supply and non-transformer environment normally to work;
Described CCD lens assembly, low-light level imaging reception for the detection targets such as biochip are sent upload the data to host computer simultaneously;
Described focusing locating rack module, control CCD lens assembly height, guarantee that the detection target imagings such as genetic chip are clear, contain the detection target face such as genetic chip moderate, on it, radiating block is for reducing high-power components temperature in CCD lens assembly, guarantees that it normally works;
The worn-out photo structure module of described inner casing, for shielding the impact of external environmental interference light on detection target imagings such as chips;
Described chips etc. detect target carrying platform module, are fixedly connected with, for different targets that detect such as filling, taking-up, placement and location biochip, immunity percolation and immunochromatographies with sliding module;
Described sliding module, moves for the push-and-pull in shell module of the detection target carrying platform modules such as chip;
The invention has the beneficial effects as follows:
1, simple for structure reliable, assembling and setting is convenient, and system stability is good, reduces related personnel's Professional Demand;
2, the present invention is applied to the instrument that the chemiluminescence signals such as biochip, immunity percolation and immunochromatography detect, and control circuit and acquisition technology are ripe, have work efficiency feature high, simple to operate;
3, the development of biochip, immunity percolation and immunochromatography, production and application will bring revolutionary variation to the diagnosis of disease, medicine; A kind of portable multi-purpose chemiluminescence imager of simple for structure, simple to operate, reasonable price, dependable performance has realistic meaning to the penetration and promotion of biochip.
On the basis of technique scheme, the present invention can also do following improvement.
Further, described shell module comprises housing, handle and adjustment location-plate; Described handle is connected to described case top by revolution bearing pin; At the bottom of the worn-out light of described adjustment location-plate and the worn-out photo structure module of inner casing, box is screwed and is connected.Adopt the beneficial effect of above-mentioned further scheme to be, be conducive to instrument integral body and carry.
Further, the worn-out optical module of described protecgulum comprises drawer lid, attacker; Described attacker is flush-mounted in drawer lid; The detection target plummer front ends such as described drawer lid and chip are connected.Adopt the beneficial effect of above-mentioned further scheme to be, guarantee that front end end cover shielding external environment light disturbs, the push-and-pull of being convenient to the detection target plummers such as chip is moved.
Further, described circuit module provides power for CCD lens assembly, for there being CCD assembly under power supply and non-transformer environment normally to work.Adopt the beneficial effect of above-mentioned further scheme to be, range of application is more wide in range, is convenient to popularize.
Further, described CCD lens assembly is fixed on the transverse slat of focusing locating rack module, can adjust as required height.
Further, described focusing locating rack module comprises column and transverse slat; Described column by little fixing feet and large fixing feet and worn-out light at the bottom of box be located by connecting, transverse slat meets at right angles and is connected with column.
Adopt the beneficial effect of above-mentioned further scheme to be, be convenient to CCD assembly location and installation, set up focal length.
Further, the worn-out photo structure module of described inner casing comprises box and worn-out light shield at the bottom of worn-out light; Described worn-out light shield is inlaid at the bottom of worn-out light on box, forms confined space.Adopt the beneficial effect of above-mentioned further scheme to be, can effectively shield external environment light and disturb, improve stability and the reliability of image data.
Further, the detection target carrying platform module such as described chip comprises that chip etc. detects target plummer, limited block; Described chips etc. detect target plummer, have and be applicable to the different customization stations that detect target of biochip, immunity percolation and immunochromatography on it; Described limited block is screwed on the detection target plummers such as chip; The detection target plummers such as described chip are screwed on the slide block of sliding module, along slide rail, slide, and by limited block, are located and are pulled out length.
Adopt the beneficial effect of above-mentioned further scheme to be, guarantee the different placements that detect target such as biochip, immunity percolation and immunochromatography; Guarantee that the detection target plummer push-and-pulls such as chip are smooth and easy, accurate positioning, the detection targets such as biochip take conveniently, and camera positioning is accurate.
Further, described sliding module comprises slide block and slide rail; Described slide rail is fixed by screws at the bottom of worn-out light on box, and slide block slides at slide rail.
Adopt the beneficial effect of above-mentioned further scheme to be, tracks is accurate, guarantee camera position in long-term use procedure accurately.
Accompanying drawing explanation
Fig. 1 is that the present invention is for the structural representation of the multi-purpose portable chemiluminescence imaging system of biochip, immunity percolation and immunochromatography detection;
Fig. 2 is the front view of Fig. 1;
Fig. 3 is the rear axle mapping of Fig. 1;
Fig. 4 is the front axonometric drawing of Fig. 1;
In accompanying drawing, the list of parts of each label representative is as follows:
1, housing, 2, drawer lid, 3, CCD lens assembly, 4, radiating block, 5, location-plate, 6, column, 7, worn-out light shield, 8, little fixing feet, 9, pressing plate, 10, chip etc. detects target plummer, 11, slide rail, 12, adjust location-plate, 13, leg, 14, slide block, 15, box at the bottom of worn-out light, 16, limited block, 17, large fixing feet, 18, circuit module, 19, transverse slat, 20, handle, 21, revolution bearing pin, 22, net port, 23, supply socket, 24, attacker
Embodiment
Below in conjunction with accompanying drawing, principle of the present invention and feature are described, example, only for explaining the present invention, is not intended to limit scope of the present invention.
A portable multi-purpose chemiluminescence imager, comprises that shell module, the worn-out optical module of protecgulum, circuit module, CCD lens assembly, focusing locating rack module, the worn-out photo structure module of inner casing, chip etc. detect target carrying platform module, sliding module;
Described shell module, encapsulates whole instrument parts, and internally environment carries out preliminary worn-out light, and upper end is provided with handle, is connected with bottom screw, is convenient to integral body and carries;
The worn-out optical module of described protecgulum, for the detection target carrying platform module shift-in housings such as described chip provide worn-out light trap lid, the detection target carrying platform such as built-in attacker's convenient operation person push-and-pull chip it on;
Described circuit module, for described CCD lens assembly provides power, for there being CCD assembly under power supply and non-transformer environment normally to work;
Described CCD lens assembly, low-light level imaging reception for the detection targets such as biochip are sent upload the data to host computer simultaneously;
Described focusing locating rack module, control CCD lens assembly height, guarantee that the detection target imagings such as genetic chip are clear, contain the detection target face such as genetic chip moderate, on it, radiating block is for reducing high-power components temperature in CCD lens assembly, guarantees that it normally works;
The worn-out photo structure module of described inner casing, for shielding the impact of external environmental interference light on detection target imagings such as chips;
Described chips etc. detect target carrying platform module, are fixedly connected with, for different targets that detect such as filling, taking-up, placement and location biochip, immunity percolation and immunochromatographies with sliding module;
Described sliding module, moves for the push-and-pull in shell module of the detection target carrying platform modules such as chip.
As shown in Figure 1 and Figure 2, described shell module comprises housing 1, handle 20 and adjusts location-plate 12; Described handle 20 is connected to described housing 1 top by revolution bearing pin 21; At the bottom of the worn-out light of described adjustment location-plate 12 and the worn-out photo structure module of inner casing, box 15 is screwed and is connected.
As shown in Figure 1, Figure 2, Figure 4 shows, the worn-out optical module of described protecgulum comprises drawer lid 2, attacker 24; Described attacker 24 is flush-mounted in drawer lid 2; Detection target plummer 10 front ends such as described drawer lid 2 and chip are connected.
Described circuit module provides power for CCD lens assembly 3, for there being CCD assembly 3 under power supply and non-transformer environment normally to work.
Described CCD lens assembly 3 is fixed on the transverse slat 19 of focusing locating rack module, can adjust as required height.
Described focusing locating rack module comprises column 6 and transverse slat 19; Described column 6 is located by connecting with box 15 at the bottom of worn-out light by little fixing feet 8 and large fixing feet 17, and transverse slat 19 meets at right angles and is connected with column 6.
The worn-out photo structure module of described inner casing comprises box 15 and worn-out light shield 7 at the bottom of worn-out light; Described worn-out light shield 7 is inlaid at the bottom of worn-out light on box 15, forms confined space.
The detection target carrying platform modules such as described chip comprise detection target plummer 10, the limited blocks 16 such as chip; Detection target plummers such as described chip 10 have on it and are applicable to the different customization stations that detect target such as biochip, immunity percolation and immunochromatography; Described limited block 16 is screwed on the detection target plummers 10 such as chip; The detection target plummers 10 such as described chip are screwed on the slide block 14 of sliding module, along slide rail 11, slide, and by limited block 16 location, pull out length.
Described sliding module comprises slide block 14 and slide rail 11; Described slide rail 11 is fixed by screws at the bottom of worn-out light on box 15, and slide block 14 slides at slide rail 11.
The present invention is as follows for a kind of principle of work of portable multi-purpose chemiluminescence imager:
First the detection target plummers 10 such as chip are pulled out from housing 1 by attacker 24, target is detected in the institutes such as biochip, immunity percolation and immunochromatography and put into the detection target plummer 10 customization stations such as chip, then the detection target plummers 10 such as chip are pushed in housing 1, guarantee that 2 sealings of drawer lid put in place, opening power and upper computer analyzing software are carried out image capture and analysis.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. a portable multi-purpose chemiluminescence imager, is characterized in that: comprise that shell module, the worn-out optical module of protecgulum, circuit module, CCD lens assembly, focusing locating rack module, the worn-out photo structure module of inner casing, chip etc. detect target carrying platform module, sliding module;
Described shell module, encapsulates whole instrument parts, and internally environment carries out preliminary worn-out light, and upper end is provided with handle, is connected with bottom screw, is convenient to integral body and carries;
The worn-out optical module of described protecgulum, for the detection target carrying platform module shift-in housings such as described chip provide worn-out light trap lid, built-in attacker's convenient operation person push-and-pull chip bearing platform on it;
Described circuit module, for described CCD lens assembly provides power, for there being CCD assembly under power supply and non-transformer environment normally to work;
Described CCD lens assembly, receives for the low-light level imaging that the detection targets such as biochip are sent, and upload the data to host computer simultaneously;
Described focusing locating rack module, control CCD lens assembly height, guarantee that the detection target imagings such as genetic chip are clear, contain the detection target face such as genetic chip moderate, on it, radiating block is for reducing high-power components temperature in CCD lens assembly, guarantees that it normally works;
The worn-out photo structure module of described inner casing, for shielding the impact of external environmental interference light on detection target imagings such as chips;
Described chips etc. detect target carrying platform module, are fixedly connected with, for different targets that detect such as filling, taking-up, placement and location biochip, immunity percolation and immunochromatographies with sliding module;
Described sliding module, moves for the push-and-pull in shell module of the detection target carrying platform modules such as chip.
2. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: described shell module comprises housing (1), handle (20) and adjusts location-plate (12); Described handle (20) is connected to described housing (1) top by revolution bearing pin (21); At the bottom of the worn-out light of described adjustment location-plate (12) and the worn-out photo structure module of inner casing, box (15) is screwed and is connected.
3. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: the worn-out optical module of described protecgulum comprises drawer lid (2), attacker (24); Described attacker (24) is flush-mounted in drawer lid (2); Detection target plummer (10) front ends such as described drawer lid (2) and chip are connected.
4. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: described circuit module is that CCD lens assembly (3) provides power, for there being CCD assembly (3) under power supply and non-transformer environment normally to work.
5. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: described CCD lens assembly (3) is fixed on the transverse slat (19) of focusing locating rack module, can adjust as required height.
6. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: described focusing locating rack module comprises column (6) and transverse slat (19); Described column (6) is located by connecting with box (15) at the bottom of worn-out light by little fixing feet (8) and large fixing feet (17), and transverse slat (19) meets at right angles and is connected with column (6).
7. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: the worn-out photo structure module of described inner casing comprises box (15) and worn-out light shield (7) at the bottom of worn-out light; At the bottom of described worn-out light shield (7) is inlaid in worn-out light, box (15) is upper, forms confined space.
8. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: the detection target carrying platform modules such as described chip comprise detection target plummer (10), the limited blocks (16) such as chip; On the detection target plummers (10) such as described chip, have and be applicable to the different customization stations that detect target of biochip, immunity percolation and immunochromatography; Described limited block (16) is screwed on the detection target plummers (10) such as chip; The detection target plummers (10) such as described chip are screwed at the slide block (14) of sliding module upper, along slide rail (11), slide, and by limited block (16) location, pull out length.
9. a kind of portable multi-purpose chemiluminescence imager according to claim 1, is characterized in that: described sliding module comprises slide block (14) and slide rail (11); At the bottom of described slide rail (11) is fixed by screws in worn-out light, box (15) is upper, and slide block (14) (11) on slide rail slides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310013267.XA CN103926238A (en) | 2013-01-14 | 2013-01-14 | Portable multipurpose chemiluminescence imager |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310013267.XA CN103926238A (en) | 2013-01-14 | 2013-01-14 | Portable multipurpose chemiluminescence imager |
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| CN103926238A true CN103926238A (en) | 2014-07-16 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104865262A (en) * | 2015-06-15 | 2015-08-26 | 黄浩 | Portable biological chip detection device |
| CN105181699A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Onboard seaborne/vehicle-mounted terrestrial biota chip detection system |
| CN105181700A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Biochip detector |
| CN106124778A (en) * | 2016-07-27 | 2016-11-16 | 深圳市博卡生物技术有限公司 | Immunoblotting assay instrument |
| CN108931634A (en) * | 2018-05-30 | 2018-12-04 | 河南豫乾技术转移中心有限公司 | Immune detection monitoring device equipped with check plot |
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| CN2816811Y (en) * | 2005-02-24 | 2006-09-13 | 穆海东 | Biological chip detecting instrument |
| US20080095669A1 (en) * | 2006-10-24 | 2008-04-24 | Korea Electro Technology Research Institute | Apparatus for and method of measuring bio-chips using uniform total internal reflection illumination |
| CN202256165U (en) * | 2011-07-20 | 2012-05-30 | 深圳市普瑞康生物技术有限公司 | Quantitative nano-gold detection analyzer |
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| CN1508266A (en) * | 2002-12-16 | 2004-06-30 | 中国科学院光电技术研究所 | Biochip detecting system |
| CN2816811Y (en) * | 2005-02-24 | 2006-09-13 | 穆海东 | Biological chip detecting instrument |
| US20080095669A1 (en) * | 2006-10-24 | 2008-04-24 | Korea Electro Technology Research Institute | Apparatus for and method of measuring bio-chips using uniform total internal reflection illumination |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104865262A (en) * | 2015-06-15 | 2015-08-26 | 黄浩 | Portable biological chip detection device |
| CN105181699A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Onboard seaborne/vehicle-mounted terrestrial biota chip detection system |
| CN105181700A (en) * | 2015-09-29 | 2015-12-23 | 宁波大学 | Biochip detector |
| CN105181700B (en) * | 2015-09-29 | 2018-12-07 | 浙江正力安拓生物科技有限公司 | A kind of biochip supplies analysis |
| CN105181699B (en) * | 2015-09-29 | 2019-02-22 | 浙江正力安拓生物科技有限公司 | A kind of marine/vehicle-mounted terrestrial life chip detecting system of boat-carrying |
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| CN108931634A (en) * | 2018-05-30 | 2018-12-04 | 河南豫乾技术转移中心有限公司 | Immune detection monitoring device equipped with check plot |
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