CN103920054A - Compound medicament for treating diarrhea before dawn and preparation method thereof - Google Patents
Compound medicament for treating diarrhea before dawn and preparation method thereof Download PDFInfo
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Abstract
The invention provides a compound medicament for treating diarrhea before dawn. The compound medicament is prepared from the following raw medicinal materials in parts by weight: 15-25 parts of fructus forsythiae, 12-18 parts of mint, 40-60 parts of cinnamon, 35-55 parts of poria, 20-30 parts of plantain seed, 22-33 parts of monkshood, 25-30 parts of agastache rugosus, 20-30 parts of semen euryales, 28-40 parts of eucommia, 30-50 parts of maltose, 30-50 parts of millet and 35-60 parts of yeast glucan. The compound medicament contains multiple components capable of resisting viruses and bacteria, has the functions of tonifying fire and helping yang, tonifying spleen and harmonizing stomach, is rich in nutrition, can be used for reinforcing the body functions and improving the intestinal environment, and has mild drug property, no irritation and no toxic or side effect; multiple components are synergetic, the drug effect is more prominent, and the effect for treating and improving the symptoms of a patient with diarrhea before dawn is remarkable.
Description
Technical field
The invention belongs to medicine preparation field, be specially a kind of compound medicine for the treatment of morning diarrhea and preparation method thereof.
Background technology
Diarrhoea is that diarrhea before dawn has another name called " morning diarrhea ", and the time of referring to has a pain under umbilicus before occurring in dawn, and borborygmus rush down, a kind of disease of pacifying after rushing down.Having obvious division of day and night feature, is commonly encountered diseases, frequently-occurring disease clinically, and the course of disease is long, and touching difficulty more.The traditional Chinese medical science thinks, " diarrhea before dawn " is mainly due to due to kidney yang deficiency.People, to old, has bad physiques, and yang-energy day by day declines, and causes eventually insufficiency of kidney-YANG and forms.Have loose bowels with the passing of time, insufficiency of kidney-YANG, decline of the fire from the gate of life, can not warm spleen sun and digesting food, and dysfunction of the spleen in transportation and transformation adds hypofunction of YANG QI before dawn, more severe YIN-cold, therefore abdominal part is had a pain, borborygmus rush down.Rush down rear internal organs gas tonneau, therefore pacify after rushing down.As for anorexia, spiritlessness and weakness, coldness of the body with chills, soreness of the waist and knees, be kidney yang day by day void decline, can not be warm spleen sun, the symptom of deficiency of spleen-YANG and kidneyYANG.Pale tongue with white fur, pulse condition is heavy thin, is the resembling of deficiency and coldness of human body inherence, belongs to interior syndrome, deficiency syndrome, cold syndrome.
Summary of the invention
The object of this invention is to provide a kind of compound medicine for the treatment of morning diarrhea and preparation method thereof.
The present invention treats the compound medicine of morning diarrhea, by the crude drug of following parts by weight: 35～60 parts of 15～25 parts of Fructus Forsythiaes, 12～18 parts of Herba Menthaes, 40～60 parts of Cortex Cinnamomis, 35～55 parts, Poria, 20～30 parts of Semen Plantaginiss, 22～33 parts of Radix Aconiti Lateralis Preparatas, 25～30 parts of Herba Pogostemoniss, 20～30 parts of Semen Euryaless, 28～40 parts of the Cortexs Eucommiae, 30～50 parts of maltose, 30～50 parts of Semen setariaes, yeast dextran are made.
As optimization, the compound medicine of this treatment morning diarrhea, by the crude drug of following parts by weight: 50 parts of 16 parts of Fructus Forsythiaes, 13 parts of Herba Menthaes, 45 parts of Cortex Cinnamomis, 38 parts, Poria, 23 parts of Semen Plantaginiss, 25 parts of Radix Aconiti Lateralis Preparatas, 28 parts of Herba Pogostemoniss, 22 parts of Semen Euryaless, 33 parts of the Cortexs Eucommiae, 40 parts of maltose, 45 parts of Semen setariaes, yeast dextran are made.
The method of preparing this compound medicine, comprises the following steps:
A, the Semen Plantaginis of getting described parts by weight, Herba Pogostemonis, Fructus Forsythiae, Herba Menthae, add 75～85% alcohol reflux 3～4 times, each 2～3 hours, each 4～5 times of quantity of solvent, collecting decoction, filters, be condensed into the extractum of 1.00～1.35 (60 ° of C), dry powder process;
B, the Cortex Cinnamomi of getting described parts by weight, Poria, Radix Aconiti Lateralis Preparata, Semen Euryales, the Cortex Eucommiae are made respectively 300～500 object powder, add in V-Mixer mix homogeneously;
C, get the Semen setariae of described parts by weight, add in the water of 100 parts; Be cooked into pasty state, then dry and make powder;
D, the maltose of getting described parts by weight and yeast dextran, together with the powder in step a, the mixed-powder in step b, the powder in step c, add in V-Mixer mix homogeneously.
In compound medicine prescription of the present invention, the pharmacological action such as that Fructus Forsythiae has is antibacterial, heart tonifying, diuresis, town are told, is the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, symptom, its bacteriostasis and the Flos Lonicerae broadly similars such as anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.
Herba Menthae is one of Chinese conventional Chinese medicine, and it is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.
Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Also can be used as food materials use, have cake, Poria cocos congee, very nutritious, taste is gentle.
Semen Plantaginis clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances.Cure mainly accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.
Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by the effect of wind-cold damp pathogen.Cure mainly YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, arthralgia due to cold-dampnes etc.
Herba Pogostemonis slightly warm in nature, acrid-sweet flavor, there is removing dampness by means of aromatics, deliver expelling summer-heat, inducing diaphoresis to expel pathogens, dampness removing except wind, relieve heat and thirst, stomach function regulating preventing or arresting vomiting, fast gas and in, the effect such as stomach invigorating damp eliminating.Be used for the treatment of have a headache and fever, the disease such as anemofrigid cold, abdominal distention uncomfortable in chest, cold syndrome of the stomach pain, vomiting, dysentery, halitosis, but hyperactivity of fire caused by deficiency of YIN person diet.
Semen Euryales nature and flavor are sweet flat, nontoxic, invigorating the spleen and replenishing QI, for nourishing robustness food, a bit similar with Semen Nelumbinis, but the convergence sedation of Semen Euryales is stronger than Semen Nelumbinis, and applicable dry chronic diarrhea and frequent micturition, emission, weakness, the enuresis, old people's frequent micturition, women are with many soreness of waist etc.Semen Euryales seed is eaten raw and can be controlled pharyngitis.
Cortex Eucommiae sweet in the mouth, warm in nature.Return liver, kidney, stomach warp.Effect liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.The lumbago and skelalgia that treatment insufficiency of kidney-YANG causes or aching and limp unable.Born of the same parents' tire that deficiency of liver-QI causes is not solid, the diseases such as scrotum pruritus due to damp pathogen.
Maltose belongs to disaccharidase class, and white, needle-shaped crystals is soluble in water.Taste is sweet but not as good as sucrose, have the effect of strengthening the spleen and stomach, nourishing the lung to arrest cough, is all-ages food.
Semen setariae QI invigorating, spleen reinforcing, stomach function regulating, sleeps peacefully.Suitable weakness of the spleen and stomach, regurgitation, vomit, have loose bowels, or the people of dyspeptic abdominal flatulence is edible; Suitable insomnia, or the empty low grade fever person of body is edible.Should cook congee edible.
Yeast dextran can improve the ability that body opposing virus, antibacterial etc. infect.Effectively adjust gastral micro-ecology in body, the excretion of nuisance in the propagation of probiotics and intestinal in promotion body.Can reduce body inner cholesterol content, can reduce low density lipoprotein, LDL content in body, and increase the content of high density lipoprotein.
The present invention contains multiple opposing virus, antibacterial composition, mends fire supporing yang, and strengthening the spleen stomach function regulating is nutritious, and energy enhancing body function, improves intestinal environment; Its property of medicine is gentle, non-stimulated and toxic and side effects; Multicomponent is collaborative, and drug effect is more outstanding, treats and improves morning diarrhea patient symptom successful.
Relevant clinical data is as follows:
Physical data: total case 200 examples, male 115 examples wherein, female's 85 examples; The oldest 71 years old, minimum 45 years old, average 58 years old; The course of disease is the longest 8 years, the shortest 0.6 year, average 3.6 years.Be equally divided at random two groups.Two groups of case there was no significant differences (P > 0.05), have comparability.
Diagnostic criteria.With reference to the relevant criterion evaluation curative effect in (diarrhea before dawn) diagnostic criteria and < < new Chinese medicine guideline of clinical investigations > > of having loose bowels of kidney yang deficiency syndrome in < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > >.1. before dawn, have loose bowels, companion's umbilicus abdomen is had a pain, and borborygmus rush down, and rush down lower complete paddy, after rushing down, pacify.2. the course of disease is more than half a year.3. with coldness of the body with chills, soreness of the waist and knees, poor appetite is weak.4. pale tongue with white fur, deep-thready pulse.Exclusion standard 1. auxiliary examinations prompt for the diseases such as bacillary dysentery, amebic dysentery, tuberculosis of intestine, colon cancer.Diabetics, have serious cardiac, scar diathesis person.3. age of sucking or pregnancy women.
Therapeutic Method: two groups of each 100 examples, matched group, adopts Beijing Tongrentang SISHEN WAN, oral, one time 9 grams, 1-2 times on the one, 40 days courses for the treatment of.Treatment group, adopts the capsule in the embodiment of the present invention 1, each serving with 2, and three times on the one, 40 days courses for the treatment of.
Criterion of therapeutical effect: cure: stool is shaped, had a pain before dawn, the transference cure such as borborygmus, morning diarrhea in umbilicus week.Effective: stool is shaped or paste, dawn before, to have a pain in umbilicus week, borborygmus disappear, idol has morning diarrhea.Invalid: defecate shapeless, before dawn, umbilicus week has a pain, and has and rush down meaning, morning diarrhea before borborygmus.Be correlated with efficacy result in Table 1, table 2.
The specific embodiment
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; according to the present invention, content, to nonessential improvement and adjustment more of the present invention, still belongs to protection scope of the present invention to those skilled in the art.
Embodiment 1, a, gets 23 grams of Semen Plantaginiss, 28 grams of Herba Pogostemoniss, 16 grams of Fructus Forsythiaes, 13 grams of Herba Menthaes, adds 75～85% alcohol reflux 3～4 times, each 2～3 hours, each 4～5 times of quantity of solvent, collecting decoction, filter, be condensed into the extractum of 1.00～1.35 (60 ° of C), dry powder process;
B, get 33 grams of 45 grams of Cortex Cinnamomis, 38 grams, Poria, 25 grams of Radix Aconiti Lateralis Preparatas, 22 grams of Semen Euryaless, the Cortex Eucommiae and make respectively 300～500 object powder, add in V-Mixer mix homogeneously;
C, get 45 grams of Semen setariaes, add in the water of 100 grams; Be cooked into pasty state, then dry and make powder;
D, get 50 grams of 40 grams of maltose and yeast dextrans, together with the powder in step a, the mixed-powder in step b, the powder in step c, add in V-Mixer mix homogeneously.In incapsulating according to 0.65 gram one.
Embodiment 2, a, get 20 grams of Semen Plantaginiss, 25 grams of Herba Pogostemoniss, 15 grams of Fructus Forsythiaes, 12 grams of Herba Menthaes, add 75～85% alcohol reflux 3～4 times, each 2～3 hours, each 4～5 times of quantity of solvent, collecting decoction, filter, be condensed into the extractum of 1.00～1.35 (60 ° of C), dry powder process;
B, get 28 grams of 40 grams of Cortex Cinnamomis, 35 grams, Poria, 22 grams of Radix Aconiti Lateralis Preparatas, 20 grams of Semen Euryaless, the Cortex Eucommiae and make respectively 300～500 object powder, add in V-Mixer mix homogeneously;
C, get 30 grams of Semen setariaes, add in the water of 100 grams; Be cooked into pasty state, then dry and make powder;
D, get 35 grams of 30 grams of maltose and yeast dextrans, together with the powder in step a, the mixed-powder in step b, the powder in step c, add in V-Mixer mix homogeneously.In incapsulating according to 0.65 gram one.
Embodiment 3, a, get 30 grams of Semen Plantaginiss, 30 grams of Herba Pogostemoniss, 25 grams of Fructus Forsythiaes, 18 grams of Herba Menthaes, add 75～85% alcohol reflux 3～4 times, each 2～3 hours, each 4～5 times of quantity of solvent, collecting decoction, filter, be condensed into the extractum of 1.00～1.35 (60 ° of C), dry powder process;
B, get 40 grams of 60 grams of Cortex Cinnamomis, 55 grams, Poria, 33 grams of Radix Aconiti Lateralis Preparatas, 30 grams of Semen Euryaless, the Cortex Eucommiae and make respectively 300～500 object powder, add in V-Mixer mix homogeneously;
C, get 50 grams of Semen setariaes, add in the water of 100 grams; Be cooked into pasty state, then dry and make powder;
D, get 60 grams of 50 grams of maltose and yeast dextrans, together with the powder in step a, the mixed-powder in step b, the powder in step c, add in V-Mixer mix homogeneously.In incapsulating according to 0.65 gram one.
Claims (3)
1. a compound medicine for the treatment of morning diarrhea; It is characterized in that the crude drug by following parts by weight: 35～60 parts of 15～25 parts of Fructus Forsythiaes, 12～18 parts of Herba Menthaes, 40～60 parts of Cortex Cinnamomis, 35～55 parts, Poria, 20～30 parts of Semen Plantaginiss, 22～33 parts of Radix Aconiti Lateralis Preparatas, 25～30 parts of Herba Pogostemoniss, 20～30 parts of Semen Euryaless, 28～40 parts of the Cortexs Eucommiae, 30～50 parts of maltose, 30～50 parts of Semen setariaes, yeast dextran are made.
2. the compound medicine for the treatment of morning diarrhea according to claim 1, is characterized in that the crude drug by following parts by weight: 50 parts of 16 parts of Fructus Forsythiaes, 13 parts of Herba Menthaes, 45 parts of Cortex Cinnamomis, 38 parts, Poria, 23 parts of Semen Plantaginiss, 25 parts of Radix Aconiti Lateralis Preparatas, 28 parts of Herba Pogostemoniss, 22 parts of Semen Euryaless, 33 parts of the Cortexs Eucommiae, 40 parts of maltose, 45 parts of Semen setariaes, yeast dextran are made.
3. a method of preparing compound medicine described in claim 1, is characterized in that comprising the following steps:
A, the Semen Plantaginis of getting described parts by weight, Herba Pogostemonis, Fructus Forsythiae, Herba Menthae, add 75～85% alcohol reflux 3～4 times, each 2～3 hours, each 4～5 times of quantity of solvent, collecting decoction, filters, be condensed into the extractum of 1.00～1.35 (60 degrees Celsius), dry powder process;
B, the Cortex Cinnamomi of getting described parts by weight, Poria, Radix Aconiti Lateralis Preparata, Semen Euryales, the Cortex Eucommiae are made respectively 300～500 object powder, add in V-Mixer mix homogeneously;
C, get the Semen setariae of described parts by weight, add in the water of 100 parts; Be cooked into pasty state, then dry and make powder;
D, the maltose of getting described parts by weight and yeast dextran, together with the powder in step a, the mixed-powder in step b, the powder in step c, add in V-Mixer mix homogeneously.
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Patent Citations (3)
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| CN101780247A (en) * | 2010-02-28 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating acute enteritis and preparation method thereof |
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