CN1528375A - Chinese medicine for treating protrasion of the lumber intervertebral disci - Google Patents

Abstract

The present invention discloses a Chinese mecicine for curing prolapse of lumbar intervertebral disc with obvious therapeutic effect. Said medicine is made up by using 9 Chinese medicinal materials of carthamus flower, achryanthes root, Chinese angelica root, toosendan fruit, peach kernel and others.

Description

A kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion

(1) technical field: the present invention relates to a kind of Chinese medicine that is used for the treatment of prolapse of lumbar intervertebral disc, belong to the Chinese medicine technical field.

(2) background technology: prolapse of lumbar intervertebral disc is a kind of common and be difficult to the lumbar vertebra activeness obstacle disease of thoroughly curing, and it has cold, the history that wets of wound, lumbar muscle strain or diseases caused by exogenous pathogenic factor more, thereby causes the qi depression to blood stasis of disease sites, and the chronic back pain history is arranged more.Its symptom is a lumbago and to the radiation of buttocks and lower limb, severe patient generation skoliosis, symptoms such as waist physiologic radian disappearance.This disease the lighter waist limitation of activity, weight person's disability.Doctor trained in Western medicine adopts physiotherapy such as traction, infrared ray, wax therapy, magnetic therapy, hydrotherapy more, percutaneous retardance treatment, and methods such as Wicresoft's interventional therapy are even adopt operative treatment.The traditional Chinese medical science adopts cold expelling to dry, declare the Therapeutic Method of the network of promoting blood circulation more.Usually adopt Chinese medicinal formulae, Chinese patent medicine such as Chinese medicine decoction, dispelling wind Pain-Stopping Pill, DAHUOLUO WAN, Tongbi pill, YAOTONGNING, joint ZHUANGGU WAN or be equipped with analgesic in the Western medicine etc. again.The weak point of these Therapeutic Method and decoction, Chinese patent medicine or analgesic be the course of treatment long, curative effect is very not remarkable, the patient suffering is big, side effect is many, the not very good and easy recurrence of cure rate, patient economy burden is big.

(3) summary of the invention: the object of the present invention is to provide a kind of short treating period, evident in efficacy and difficult recurrence, patient's no pain, have no side effect, and the Chinese medicine of the low treatment lumbar intervertebral disc protrusion of cost.

A kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion is characterized in that it is made by weight by following Chinese crude drug: Flos Carthami 5-25 part Radix Achyranthis Bidentatae 7-20 part Radix Angelicae Sinensis 6---20 parts of Fructus Toosendan 3-10 part Semen Persicae 7-20 part Scorpio 2-8 part Squama Manis 3-9 part Scolopendra 3-9 part Radix Glycyrrhizae 6-30 parts

The preferred weight proportioning of said components is: Flos Carthami 10-20 part Radix Achyranthis Bidentatae 10-17 part Radix Angelicae Sinensis 10-18 part Fructus Toosendan 5-8 part Semen Persicae 10-17 part Scorpio 3-6 part Squama Manis 5-7 part Scolopendra 5-7 part Radix Glycyrrhizae 15-25 part

The optimum weight proportioning of said components is: 20 parts in 6 portions of Radix Glycyrrhizaes of 6 parts of Scolopendras of 4 parts of Squama Maniss of 15 portions of Scorpios of 7 parts of Semen Persicaes of 15 parts of Fructus Toosendans of 15 parts of Radix Angelicae Sinensis of 15 parts of Radix Achyranthis Bidentataes of Flos Carthami

The present invention takes the following principles of formulating prescriptions: blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, treatment of arthritis and promoting collateral and channels.

Be the effect of Chinese crude drug of the present invention below:

The Flos Carthami acrid in the mouth, warm in nature.GUIXIN, Liver Channel.Effect with promoting blood circulation to restore menstrual flow, regulating blood flow to alleviate pains.Can be used for treating enclosed mass in amenorrhea, dysmenorrhea, the abdomen, the macule color secretly reaches diseases such as traumatic injury, blood stasis lump.The hot diffusing temperature of this product is logical, is apt to into blood system, and energy dissipating blood stasis blood, the dead blood of living, qualcomm meridian, removing blood stasis with potent drugs amass, and are the key medicine of promoting the circulation of blood removing blood stasis.With compatibilities such as Radix Angelicae Sinensis, Squama Manis with blood circulation and promoting silt, hard masses softening and resolving etc.The kind current passages through which vital energy circulates of Flos Carthami is gas medicine in the blood, removing blood stasis is arranged, invigorate blood circulation, transfer the wonderful of blood, is the key medicine of dredge the meridian passage, promoting blood circulation and stopping pain, is equal to usefulness with Semen Persicae, Radix Angelicae Sinensis, can receive the effect of activating blood circulation and dissipating blood stasis pain relieving.Flos Carthami contains flavanone derivative carthamin, Flos Carthami quinone glycoside, new Flos Carthami formula glycoside, and other contains Carthamus yellow (safflower yellow I, II, III, IV), reddening polysaccharide, still contains Palmic acid, myristic acid, lauric acid etc.Flos Carthami can prevent thrombosis and development, promotes thromboembolism, microcirculation improvement.The Flos Carthami decoct all has excitation to multiple animal uterus.Carthamus yellow has analgesia, calmness and anticonvulsant action.The contained flavochrome of Flos Carthami, Palmic acid, myristic acid, lauric acid etc. all have certain antiinflammatory action.

The sweet little bitterness of Radix Achyranthis Bidentatae sour in the mouth is flat.Return the Liver and kidney warp.The effect that removing blood stasis stimulates the menstrual flow, strong muscle touches numbness is arranged.For controlling the key medicine of gynecological, traumatology stasis of blood resistance illness.Radix Achyranthis Bidentatae is apt to into Liver and kidney, walks and can mend, can invigorating the liver and kidney, benefit deficient, bone and muscle strengthening, strong waist knee joint, the meridian dredging, sharp joint, play a flaccidity and give up, touch arthralgia pain, but the soreness of waist and knee joint for the treatment of the liver kidney deficiency, muscles and bones are unable.For the whole body arthralgia due to the anemofrigid-damp arthralgia resistance passages through which vital energy circulates QI and blood, numbness of the skin is meciless, joint joint stuffiness person, the promoting blood circulation of using, sharp joint.This moral character Bodhisattva is descending, can promoting the circulation of blood arteries and veins, repercussive blood, broken lump in the abdomen, dispelling malignant blood, the water that stimulates the menstrual flow, remove damp and hot, treating stranguria closing, can control haematemesis, the epistaxis of top bleeding due to blood-heat, the headache of toothache, aphtha and hyperactivity of YANG due to deficiency of YIN due to the hyperactivity of fire caused by deficiency of YIN, dizzy etc.Radix Achyranthis Bidentatae contains triterpenoid saponin, polysaccharide, several amino acids, alkaloids, Coumarins; Other contains molting hormone, and ecdysone, inokosterone are arranged; Still contain potassium salt and phlegmatic temperament etc.The pure immersion of Radix Achyranthis Bidentatae has antiinflammatory action, and Radix Achyranthis Bidentatae decoct lumbar injection has analgesic activity, and Radix Achyranthis Bidentatae decoct or alcohol extract have diuresis, and Radix Achyranthis Bidentatae has excitation to rabbit uterus.

The hot little hardship of Radix Angelicae Sinensis sweet in the mouth, warm in nature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation.All blood deficiency blood stasis of holding concurrently causes menoxenia, puerperal abdonimal pain, and all pains of cold blood stasis are key medicine.The sweet suffering of Radix Angelicae Sinensis is gentle, and it is all good to enrich blood, invigorate blood circulation." invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, also the panacea in the blood is also ".The light flavor of Radix Angelicae Sinensis gas is dense, can walk and can keep, go into conscience and can give birth to the moonization sun, nourshing blood and promoting blood circulation, walk spleen channel, the stagnant gas of row and diffusing precise and tiny, change is living enriches blood.Because of stagnating, the blood deficiency stasis of blood causes pain person, the nourishing blood and dissolving stasis of using, normal and the stagnant Semen Persicae of row, the Flos Carthami etc. mutually 5 of invigorating blood circulation.With compatibilities such as Radix Achyranthis Bidentatae, Flos Carthamis, can be used for treating qi depression to blood stasis, hematogenous blockage person.Radix Angelicae Sinensis contains volatile oil component, neutral oil accounts for 88%, cyclobutenyl phenol, australene, β-Pai alkene is arranged, to the poly-florigen of umbrella, β-phellandrene, myrcene, new Radix Angelicae Sinensis lactone, Fructus Citri Sarcodactylis lactone, lauryl alcohol, tetradecyl alchohol, Rhizoma Ligustici lactone, vanillic acid, ferulic acid, Palmic acid etc.; Phenol oil accounts for 10%, and phenol, o-cresol, p-cresol etc. are arranged; Acid-soluble oil accounts for 2%, and anisic acid, myristic acid, dextrocamphoric acid., butanoic acid, benzoic acid, oleic acid, linoleic acid etc. are arranged; Also contain acidic polysaccharose etc.The acute myocardial infarction that ferulic acid in the Radix Angelicae Sinensis can the antagonism pituitrin causes can also anti peroxidation of lipid, antiplatelet aggregation, the anaphylactic shock of anti-antigen induction, antithrombotic form.Radix Angelicae Sinensis can be expanded peripheral blood vessel, reduces vascular resistance, quickens the stream of being engaged in.Radix Angelicae Sinensis has tangible Antiradiation injury, calmness, analgesia and hypnosis, antiinflammatory, effect such as antibiotic.

The Fructus Toosendan bitter in the mouth is cold in nature.Slightly poisonous.Return lung, the heart, stomach, large intestine channel.There are promoting the circulation of QI to relieve pain, anthelmintic to treat the effect of tinea.Cure mainly various pain due to the depressed fire-transformation of stagnation of liver-QI, other has the power of the ascarid of killing, is used for abdominal pain due to worm stagnation, and external simultaneously can be treated tinea class dermatosis.The Fructus Toosendan bitter cold is fallen and is let out, be longer than soothing the liverly expel the heat-evil, the resolving depression pain relieving.Cure mainly various pain due to the depressed fire-transformation of stagnation of liver-QI.Fructus Toosendan contains mixed ester, Fructus Toosendan ionoionone glycoside first, the Fructus Toosendan ionoionone glycoside second of 3-oxygen stearic acid, Palmic acid and the fatty acids such as myristic acid, lauric acid of Toosendanin, isochuanliansu, 21-O-methyl Fructus Toosendan amylalcohol, fat Fructus Toosendan alcohol and fat Fructus Toosendan alcohol; Still contain azedarine, bitter principle Mike suffering, kaempferol, fatty oil and tannin etc.Toosendanin can strengthen myenteron tension force and contractility, and anthelmintic action is arranged.Fructus Toosendan has inhibitory action to fungus and the little sporeformer of rust and staphylococcus aureus.Isolated Azadirachta Indica A. pyridine has tangible anti-inflammatory activity from the Fructus Toosendan seed oil.Fructus Toosendan is slightly poisonous, eats by mistake or consumption is excessive toxic reaction occurs, is mainly liver injury, and toxic hepatitis is off one's dot, and visceral hemorrhage is breathed, circulatory failure, even dead.

The Semen Persicae bitter in the mouth is flat, GUIXIN, liver, large intestine channel.Effect with removing blood stasis, moistening dryness for relaxing bowels is gathered for controlling amenorrhea, dysmenorrhea, puerperal stasis of blood pain, hundred abdominal masss, the medicine commonly used of blood stasis internal resistances such as traumatic injury congestive edema and lung abscess, acute appendicitis.Semen Persicae bitter in the mouth, property are put down, are apt to into blood system, can dissipating blood stasis blood, attack blood-retention, the dead blood of living, long-pending, the logical thinking of removing blood stasis with potent drugs, removing heat from blood heat, loose and do not receive, have rush down of no help, for controlling the key medicine of blood stasis internal resistances such as amenorrhea, dysmenorrhea, puerperal stasis of blood pain, traumatic injury congestive edema and lung abscess, acute appendicitis.Semen Persicae contains compositions such as amygdalin, volatile oil, fatty oil, amygdalase, several amino acids and protein, sugar and methyl glucoside, prunasin, steroidal, and main component is a benzaldehyde in the volatile oil.The Semen Persicae ethanol extract has the obvious suppression hemagglutinative function.Semen Persicae can be expanded peripheral vessels, reduces vascular resistance, blood flow increasing.Its contained fatty oil has the intestine moistening laxative action.Amygdalin hydrolyzable in vivo produces hydrocyanic acid, and micro-hydrocyanic acid can suppress respiratory center, and antitussive, antiasthmatic effect are arranged.Excessive Semen Persicae for oral administration can cause cyanide poisoning, benumbs respiratory center and death, and its reason is that hydrocyanic acid can make chtochrome oxidase, loses the transmission electronic action, and takes place to suffocate in the cell.

The Scorpio acrid in the mouth, property is flat, and is poisonous.Return Liver Channel.The effect that relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, detoxicating and resolving stagnation of pathogens are arranged.Scorpio is because acrid in the mouth is flat, mainly goes into Liver Channel, so stronger endogenous wind stopping relieving convulsion effect is arranged, can be used for that infantile convulsion tic, middle air port are askew, tetanus etc., can also removing obstruction in the collateral to relieve pain, and detoxicating and resolving stagnation of pathogens can be used for migraine and general headache, rheumatic numbness etc.Scorpio is good at walking string, follow table and in, can wear muscle deep, by the wet wind that removes.Be usually used in bones and muscles pain due to the wind-cold damp pathogen, hands and feet caused by paralysis person, the dispelling wind and removing obstruction in the collateral of using, removing damp and stopping pain.Share with Squama Manis etc. and can control anemofrigid-damp arthralgia.Scorpio contains scorpion venom, and wherein toxic albumen and non-toxic protein also contain trimethylamine, betanin, taurine, palmitic acid, cholest acid, aminoacid etc.Scorpio can influence the function of vasomotor center, and blood vessel dilating suppresses adrenergic boosting and blood pressure lowering, and can obviously prolong clotting time, also has effects such as antitumor, calmness.Scorpion venom has certain immunocompetence, can influence many enzymes in the tissue and influences metabolic function.Scorpio for oral administration is improper to cause the different respiration inhibition of degree, albuminuria and anaphylaxis.

Squama Manis salty in the mouth cold nature.Return liver, stomach warp.Have activating blood circulation and dissipating blood stasis, the effect of the stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis.The Squama Manis salty in the mouth, hard masses softening and resolving, so can promoting blood circulation to remove obstruction in the collateral, detumescence and apocenosis, wind-expelling pain-stopping, the stimulating milk secretion of stimulating the menstrual flow, all surgery sore and toxics, married woman's amenorrhea due to stagnation of blood and traumatic injury, rheumatic arthralgia all available it.This moral character is apt to away scurry, and is no little more than, and the energy clots absorbing stagnates, eliminating mass is long-pending, lead to menstruation, sharp nine orifices, wind-damp dispelling, pain relieves the pain.Be equal to the effect that can receive promoting blood circulation, removing blood stasis and relieving pain with Radix Angelicae Sinensis, Semen Persicae, Flos Carthami.Because having property of Squama Manis is apt to away scurry, thus among the present invention also in order to make the efficacy of a drug reach disease institute thoroughly.It is 26 and 29 two aliphatic amides, ring (L-seryl-L-tyrosyl) dipeptides, ring (D-seryl L-tyrosyl) dipeptides that Squama Manis contains stearic acid, cholesterol, two tridecanoyl butylamine, carbon number.Contain elements such as Zn, Na, Ti, Ca, Pb, Si, P, Fe, Mn, Cr, Mg, Cu, V, B, Al, Mo, Sn again; Still contain aspartic acid, threonine, serine, glutamic acid, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tyrosine, arginine, lysine, phenylalanine, 16 seed amino acids; Other contains water solublity alkaloid and volatilization wet goods.100% Squama Manis water extract-alcohol precipitation liquid can significantly increase the dog femoral artery blood flow, reduces Peripheral resistance, and blood vessel is had direct dilating effect.Lumbar injection 10% decocting liquid has obvious prolongation mice and rat clotting time, and the effect of blood viscosity lowering all has significant anti-Fructus Crotonis induced mice ear inflammatory effect after the water extract of Squama Manis, alcohol extract gavage.

The Scolopendra acrid in the mouth is warm in nature, and is poisonous.Return Liver Channel.The effect that relieving spasm by subduing liver-wind, detoxicating and resolving stagnation of pathogens are arranged still has the effect of dredge the meridian passage in addition.The hot warm-dryness syndrome that looses of Scolopendra is poisonous, and property is apt to away scurry, and is longer than to search wind and jerk surely, is endogenous wind stopping relieving convulsion key medicine; This product is poisonous, but dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain can be used for treating sore swollen toxin, headache, arthralgia pain etc.; Because its removing obstruction in the collateral to relieve pain effect, often with the product of expelling wind and removing dampness, strengthening the tendons and bones mutually 5, the dispelling the wind and dampness pathogens insensitive impediment is renderd a service good especially.There is insatiable hunger to close fatty acid in the Scolopendra liposoluble constituent and comprises oleic acid, linoleic acid, linolenic acid etc., also contain free amino acid and hydrolysis amino acid and comprise glutamic acid, aspartic acid, leucine, lysine, alanine etc., also have protein, saccharide, trace element zinc and calcium, magnesium, potassium, sodium etc.Scolopendra has antitumor, convulsion, analgesia, antiinflammatory action, and its water extract has certain inhibitory action to staphylococcus aureus, escherichia coli, and various pathomycetes are then had strong inhibitory action, can improve the phagocytic activity of macrophage and enhancing immunity.Scolopendra might cause acute liver function injury, renal damage.

The Radix Glycyrrhizae sweet in the mouth is flat.Return 12 warps.Effect with QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Radix Glycyrrhizae is sweet and gentle, and is living then cool in nature, the evil pathogenic fire purging of loosing, current meridians, the long-pending heat of elimination, removing toxicity for eliminating carbuncles, and all pyretic toxicity stasis of bloods are tied and are caused sore and toxic, congestion and swelling pain person, use this removing toxic substances and promoting subsidence of swelling; The Radix Glycyrrhizae sweet in the mouth is very dense, energy easing middle-JIAO and tonifying for deficiency, mediation flavour of a drug, the high healthy energy of protecting suddenly, admittedly of alleviation.The strong medicine phase 5 of Chang Yujun is to receive the effect of strengthening vital QI to eliminate pathogenic factors.The speciality of the emergency of Radix Glycyrrhizae, detoxifcation, the mediation property of medicine makes it other bitter cold of adapted, property hot, poisonous or high violent medicine is relaxed, and helps patient and takes.Radix Glycyrrhizae contains triterpenoid saponin, wherein mainly is glycyrrhizin; Also contain flavone compound such as licoflavone, isoliquiritigenin, glycyrrhizin, isoliquiritigenin etc.; Still contain alkaloid, polysaccharide, glycycoumarin, cupreol, trace element-selenium, germanium etc.Radix Glycyrrhizae has antibiotic and antivirus action, and wherein glycyrrhizin and licoflavone class have the anti-AIDS toxic action; Radix Glycyrrhizae has the effect of adrenocortical hormone sample, also has enhance immunity, antiinflammatory, antitussive, eliminates the phlegm, antioxidation, cholesterol reducing and triglyceride, antiarrhythmic effect; Radix Glycyrrhizae and various single, compound preparation all have certain detoxifying effect to multiple drug intoxication, metabolite poisoning, bacteriotoxin poisoning, pesticide intoxication, alimentary toxicosis; The central nervous system is also had calmness, analgesia, analgesic, convulsion and alleviates the effects such as infringement of streptomycin to vestibular nerve.

The test example

(1) animal toxicity test

Fructus Toosendan, Scorpio, Scolopendra are all poisonous medicine in the present invention's prescription, but this three flavors medicine content is few in this programme, and the synthetic toxicity that can make of its active ingredient reduces:

1, acute toxicity test

Oral medication:

1. getting medicine 3g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 50mg/ml) of 60ml standby.

2. get 20 of white mice (each 10 of male and female), every white mice gives the equal serosity 0.005ml/g of sample according to the weight and irritates stomach (being equivalent to 250mg/kg), observed 10 days, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.This product to the oral dosis tolerata of white mice more than 250mg/kg.

3. get 20 of white mice (each 10 of male and female), every white mice according to the weight respectively grouping (10 every group) give the equal serosity 0.0075ml/g of sample and 0.01ml/g irritates stomach (being equivalent to 360mg/kg, 500mg/kg respectively), observed 10 days, irritate all healthy existence of white mice of stomach 0.0075ml/g group, no toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.(white mice of filling stomach 0.01ml/g group showed the dysphoria of the degree of having nothing in common with each other in 10 days, stupor, wherein dead 2, account for 20%, unusual through the anatomic observation routine blood test, lead content in urine is slightly high, and liver function is normal, other each organs and tissues no abnormality seen is found other pneumorrhagia in 2 white mice dissections to death.This shows medicine of the present invention to the oral maximum tolerated dose of white mice at 360mg/kg.

2 accumulation toxicity tests

Mouth medication:

1. getting medicine 1g of the present invention adds water and grinds and to make full dose become the homogenate (concentration is 25mg/ml) of 40ml standby.

2. get 40 of white mice (each 20 of male and female), every white mice gives the equal serosity 0.005ml/g of sample according to the weight and irritates stomach (being equivalent to 125mg/kg) once a day, observed three months, the all healthy existence of white mice, there is not any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group be zero difference relatively.Substantially do not have in the body and accumulate.

Show through toxicity test, this medicine is at 360mg/kg to the maximum tolerated dose of mice, the accumulation toxicity test of mice is shown that the oral dose of 125mg/kg does not have to be accumulated, being higher than clinical program adult consumption is 100mg/kg, child's consumption is 36mg, unsuitable for children is taken below three years old, and this medicine is safe to the patient.

(2) clinical practice:

1, clinical diagnosis and criterion of cure

1, the 1 Chinese medicine industry standard ZY/T001.1-001.9-94 of the list of references People's Republic of China (PRC) " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " (publishing house of issue Nanjing University of State Administration of Traditional Chinese Medicine 1994 July the 1st edition).

" surgery " Wu Zaide chief editor (the 5th edition the 32nd printing in People's Health Publisher's August calendar year 2001).

" modern Chinese medicine clinical diagnostics " red legend cutting edge of a knife or a sword He Qinghu edits (People's Health Publisher's in January, 2003 front page)

The hard Liu Jihua chief editor of " osteoarthrosis CT and MRI diagnostics " Xu Aide Xu Wen (Shandong science tech publishing house 2002 May the 1st edition)

1,2 clinical diagnosis standards

1,2,1 diagnosis basis: waist wound, chronic strain are arranged or experience the cold-damp history, most of patient has the chronic back pain history at premorbid.Normal generation is between twenty and fifty.Lumbago is to buttocks and lower limb radiation, and pain increased the weight of when intra-abdominal pressure increased (as cough, sneeze).Skoliosis, the waist physiologic radian disappears, and to the lower limb radiation, the waist activity is obstructed.The lower limb innervation zone of getting involved is felt irritatedly or blunt, and amyotrophy can appear in course of disease elder.Straight lower limb is raised and to strengthen test positive, knee joint, oppositely weakens with treading on or disappears, and toe is carried on the back the power of stretching and weakened.The X line is taken the photograph sheet and is checked skoliosis, and waist physiology prolapse disappears, and the pathological interspinal crack may narrow down, and neighboring edge has hyperosteogeny.CT examination can show the position and the degree of intervertebral disk hernia.

1,2,2 tcm syndromes classification:

Syndrome of blood stasis: lumbago and skelalgia is as thorn, localized pain, and a day light night is heavy, and the waist plate is hard, and the pitching rotation is limited, the sore spot tenderness.Body of the tongue is dark violet, or ecchymosis is arranged, stringy and tense pulse or puckery.

Cold-damp syndrome: waist lower limb cold type of pain is weighing, and it is unfavorable to change one's position, and the pain that reposes does not subtract, and catches cold and wet weather increases the weight of, and limbs are sent out cold.Pale tongue, Tai Bai or greasy, deep and tense pulse or moisten slow.

Damp-heat syndrome: flank pain, lower limb is soft unable, and sore spot is with hotness, and chance heat or rainy day increase bitterly, movable back alleviation of pain, aversion to heat is thirsty, oliguria with reddish urine.Yellow and greasy fur, soft and rapid pulse or stringy and rapid pulse.

Caused by liver and kidney deficiency disease: soreness of waist pain, the lower limb knee joint is weak, and fatigue is more very, and is for sleeping in then alleviate.Partially yang deficiency person's complexion white, hands and feet being not warm, deficiency of QI with disinclination to talk, the waist lower limb is sent out cold, or sexual impotence, premature ejaculation are arranged, women's leukorrhagia is rare clearly, pale tongue, deep-thready pulse.Deficiency of YIN person partially, dry throat and mouth, flushed face, fatigue and weakness, vexed insomnia, dreaminess or seminal emission is arranged, women's leucorrhea with yellow discharge flavor is smelly, the few tongue of red tongue, stringy,thready and rapid pulse.

1,2,3 pathology typings:

One-sided intervertebral disk hernia: low back pain is accompanied a side lower limb radiating pain, and scoliosis, waist physiology lordosis reduce or disappear, and the other tenderness of pathological interspinal dish Ipsilateral vertebra can be radiated the straight-leg raising test positive along sciatic nerve to lower limb.CT examination: intervertebral disc is side-prominent to canalis spinalis one.

The bilateral intervertebral disk hernia: low back pain, companion's bilateral lower limb radiating pain, waist physiology lordosis reduces or disappears, and pathological interspinal dish both sides vertebra is other all tenderness, can radiate two lower limb straight-leg raising test positives along sciatic nerve to lower limb.CT examination: intervertebral disc is outstanding to the left and right, and as seen free piece.

Last mo(u)ld bottom half intervertebral disk hernia: most of patient only has the lumbago symptom, the visible Schmorl tuberosity of X-ray examination pathological interspinal dish.

Central type intervertebral disk hernia: except that the symptom that lumbago and skelalgia occurs, cauda equina nerve stress disorders such as perineal position numbness and fecal and urinary functions obstacle also can occur.CT examination: intervertebral disc is outstanding to the center direction.

1,2,4 Differential Diagnosiss

(1) piriformis syndrome.Buttocks skelalgia, pressure pain point be at buttocks, buttocks amyotrophy, and the nervous test of piriformis is positive.

(2) straitness of lumbar vertebrae.Also can find lumbago and skelalgia, intermittent claudication is often arranged, the pain of bending over is slow.Age of onset evening, characteristic of disease is made slow progress, and symptom is many, sign is its characteristics less.The X line is taken the photograph sheet and is shown that the degenerative change of straitness of lumbar vertebrae is extensively many and serious.Both differentiate imaging examinations such as main dependence CT.

(3) pedicle isthmus does not connect or spondylolishesis disease.Both all leg pain can occur, and spondylolishesis degree severe patient also the nerve root compression symptom can occur, and often bring out intervertebral disc degeneration, outstanding.Waist sacrum X line loxosis is taken the photograph sheet susceptible of proof fracture of vertebral pedicle, and lateral projection can be understood vertebral body and have or not slippage forward and degree thereof.

(4) nerve root and tumor of cauda equina.Nerve root sheath tumor is outstanding to the intervertebral disc proceeds posterolateral, tumor of cauda equina is similar to the clinical manifestation that give prominence in the intervertebral disc dead astern.Neural root nodule morbidity is slow, and the state of an illness increases the weight of gradually, is progressive injury, does not have the medical history that intervertebral disc prolapse brings out because of action usually.The X line is taken the photograph sheet not necessarily the intervertebral disk retrogression performance, and there is increase in pedicle of vertebral arch distance and intervertebral aperture more.Myelography, MRI (nuclear magnetic resonance, NMR) and examination of cerebrospinal fluid are main Differential Diagnosis foundations.

1,3 efficacy evaluations.Cure: lumbago and skelalgia disappears, and straight lower limb is raised more than the 70o, can recover former work.Take a turn for the better: lumbago and skelalgia alleviates, and the waist movable function improves.Do not heal: symptom, sign do not have improvement.

2, clinical data.Treat prolapse of lumbar intervertebral disc 127 examples altogether from year August June to 2003 calendar year 2001, patient age is at 20-82 between year, 20-35 year 42 examples wherein, 35-60 year 52 examples 33 examples more than 60 years old.The course of disease is the shortest to be 5 days, and elder is 4 years.Treatment time is the shortest to be 10 days, and elder is 30 days.By statistics, cure 102 examples, cure rate is 80.4%, produce effects or transfer 20 examples well to, and total effective rate is 96%.

3, administrated method.

(1), every day sooner or later each once, each bag, warm after meal yellow wine is taken after mixing it with water, 15 days is a course of treatment, obeys a course of treatment again to consolidate curative effect after serious symptom person's recovery from illness.

(2), every day sooner or later each once, each 6, warm after meal yellow wine is taken after mixing it with water, 15 days is a course of treatment, obeys a course of treatment after the recovery from illness again to consolidate curative effect.

4, from as can be seen to the discussion of technique scheme, the mutual compatibility of various medicines that prescription of the present invention adopted, with blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the principles of formulating prescriptions of treatment of arthritis and promoting collateral and channels are consistent, the Chinese medicine of treatment lumbar intervertebral disc protrusion of the present invention has reasonable recipe and comparatively simple, taking convenience, short treating period, curative effect is high and be difficult for recurrence, lower, the patient's no pain of price, have no side effect, can reduce the advantage of patient economy burden significantly, be a kind of Chinese medicine of comparatively ideal treatment lumbar intervertebral disc protrusion.

5, model case.

Example 1: Liu Yuxi, man, 82 years old, peach people from villages and small towns, Xixia City.Come here to go to a doctor on April 7th, 2002.Main suit: lumbago January, increase the weight of gradually.The state of an illness: the patient is old, and movable less, January, cause bent over to lift thing, causes lumbago, continues difficult.Invalid through medicines such as clothes ibuprofen, SHENJIN DAN, so seek medical advice in here.Four diagnostic methods finding, spirit is not good enough, painful expression, the hunchback of bending over, groan is endlessly assisted in and is examined.Waist center, L4-5 has tenderness, shows through CT examination: the L4-5 lumbar intervertebral disc is outstanding 0 to the right back, 4cm, and L3-4 bow isthmus ruptures right side N root pressurized.Obey back recovery from illness 2 courses of treatment, do not have recurrence so far.

Example 2: clothing show pretty young woman, woman, 34 years old, Xixia City Guan Li people from village.Come here to go to a doctor on May 3rd, 2003.The main suit: lumbago is surplus February.The state of an illness: the patient does not have reason and left lower extremity fiber crops pain occurs, and it is heavy that waist is felt, working for a long time, left lower extremity pain increases the weight of.Through taking somedon, tablet for relieving rigidity of muscles and promoting blood circulation etc., poor effect.Lumbar vertebra L3-4, L5-s1 intervertebral disk hernia are respectively 0.3 after the People's Hospital, Xixia City CT examination is made a definite diagnosis, 0.4cm.Take medicine and fully recover after 1 course of treatment, follow up a case by regular visits to and do not have recurrence.

Example 3: Jiang Zuchen, man, 26 years old, the worker of Yantai electrical machinery plant.Come here to go to a doctor in JIUYUE, 2002.Main suit: lumbago half a year.The state of an illness: the patient is the lift to move weight in work, and prominent sense lumbago was lain up for 1 week, and the state of an illness is not felt any better, and once takes YAOTONGNING, joint ZHUANGGU WAN, poor effect, and through massage treatment more than 20 day, the state of an illness took a turn for the better always, so seek medical advice in here again.Check: little sense lumbago of coughing, L4-5 has obvious tenderness, and it is positive that straight lower limb is raised experiment, and two lower limb do not have radiating pain, no wound.Took medicine recovery from illness 10 days.Follow up a case by regular visits to and do not have recurrence.

Example 4: Zhang Fengjun, the man, 34 years old, Cheng Donggou people from village in Xixia City was in October, 2002 here prescription on individual diagnosis.Main suit: lumbago first quarter moon.The state of an illness: the patient does not have obvious inducement and causes the RG pain before first quarter moon, and cough is also felt, and can not bend over, after the People's Hospital, Xixia City CT examination, outstanding 0.4cmm (right side N root pressure) event comes the here treatment to the L4-5 intervertebral disc to the right back.Take medicine and fully recovered in 15 days, follow up a case by regular visits to and do not have recurrence.

Example 5: Shi Yue, woman, 29 years old, Shandong Province Laiyang City people.In July, 2002 goes to a doctor in here.Main suit: lumbago 2 months.The state of an illness: heavy when light during lumbago, aggravate when meeting cold catching cold, De Rezeshu, waist and sacrum pain appears in no obvious inducement before 7 days, is difficult to stand, and numbness is arranged during RG, bends and stretches difficulty, and it is unfavorable to change one's position, walking disorder.Once obeyed tablet for alleviating pain, DAHUOLUO WAN, had been exhausted, so come the here treatment.Check that the lumbosacral region muscle rigidity is stiff, L5-S1 has obvious tenderness, and cough increases the weight of, and it is positive that straight lower limb is raised experiment, and CT shows that the L5-S1 intervertebral disc is to the outstanding 0.5cm in right back.Take medicine and fully recovered in 20 days, do not have recurrence so far.

Example 6: Zhang Hanrong, the woman, 35 years old, Han Qiao people from village in Xixia City was in first visit in June, 2002.Main suit: lumbago 2 months.The state of an illness: the patient is before 2 months, there is not obvious inducement lumbago, lay up 1 day, and carried out labor operation next day again, in that night lumbago increase the weight of, be unable to leave the bed, once took medicine, massaging does not all have improvement, so seek medical advice in here four diagnostic methods finding face light yellow complexion, expression is painful, groan is endlessly lain awake all night, and can not walk, can not stand, be seated, diet is not good enough, is hard and dry, and looks into L3-4, the L4-5 lumbar vertebra has obvious tenderness, CT shows L3-4, L4-5 intervertebral disc outstanding backward respectively 0.4cm, 0.5cm, and the two all shows the dural sac pressurized.Take medicine and fully recover 2 courses of treatment (30 days), follow up a case by regular visits to and do not have recurrence.

Example 7: Song Hailing, woman, 40 years old, Xixia City Gu Zhendou people from village.In here prescription on individual diagnosis in August calendar year 2001.Main suit: one week of lumbago.The state of an illness: prominent sense lumbago when the patient did farm work before a week, occur afterwards coughing, changing one's position, bend over all to feel lumbago, be in once that it is invalid to take tablet for alleviating pain, so come here to seek medical advice.Check: waist L3-4 has obvious tenderness, and cough increases the weight of, the straight-leg raising test positive, and diet, two is just normal, no trauma history.Take medicine and fully recovered in 10 days, do not have recurrence so far.

Example 8: Xu Mu, man, 34 years old, Xixia City Xu Jiawa people from village.In in May, 2003 here prescription on individual diagnosis.Main suit: lumbago 4 days.The state of an illness: the patient is engaged in building operation, during the lift to move weight, hears that suddenly waist has sound at work, afterwards waist and with lumbago, so come here to seek medical advice directly.Check: waist L4-5 has obvious tenderness, and cough, all feel pain when bending over and increase the weight of, the straight-leg raising test positive, two is just normal, and two lower limb do not have obvious radiating pain.Take medicine and fully recovered in 10 days, follow up a case by regular visits to and do not have recurrence.

Example 9: Wang Jianbo, man 39 years old, Nan Yan rim of the mouth, Xixia City people from village comes here to go to a doctor on July 15th, 2003.Main suit: lumbago 1 month.The state of an illness: the patient did not have obvious inducement lumbago and with left lower extremity pain, being in rests for a few days does not feel any better (thing of not taking medicine), so come here to seek medical advice before 1 month.Four diagnostic methods finding, complexion still can, lassitude, expression is painful, groan endlessly, difficulty in walking, two is just normal.Through the People's Hospital, Xixia City CT examination, L3-4, L4-5, L5-sacrum 1 intervertebral disc outstanding respectively 4.5mm, 4.5mm, 5mm, the three all shows hard synovial membrane pressurized, L5-s1 left side root compression, all facet joints do not have obvious change.After taking medicine 15 days, lower limb pain disappears, the waist hypodynia, and recovery from illness after taking medicine 15 days is followed up a case by regular visits to and is not had recurrence.

Example 10: Fan Huirong, the woman, 55 years old, people from village behind the palace, Xixia City was in July, 2002 here prescription on individual diagnosis.Main suit: lumbago 1 year and with skelalgia.The state of an illness: patient's lumbago was with skelalgia 1 year, and a left side is far more than the right side, walking disorder, and joint stuffiness, pain is also felt in cough.Once all invalid in how tame hospital through massage, acupuncture, traction therapeutic, drug blockage treatment etc., so come here to seek medical advice.Four diagnostic methods finding, the patient is often in field labour, and development nutrition is medium, the face light yellow complexion, waist border calmness is heavily stagnant, and diet two is just no abnormal.Looking into L3-4, L4-5 has obvious tenderness, and oppresses left lower extremity radioactivity fiber crops pain to ankle, can not bend and stretch, and local nothing redness can not be stood the straight-leg raising test positive, no trauma history during pain.After taking medicine 15 days, waist, lower limb, ankle activity for consolidating curative effect, continue clothes recovery from illness after 15 days, do not have recurrence freely so far.

(4) specific embodiment: following the specific embodiment of the present invention is elaborated:

Embodiment 1: in the ratio of Flos Carthami 5Kg Radix Achyranthis Bidentatae 7Kg Radix Angelicae Sinensis 6Kg Fructus Toosendan 3Kg Semen Persicae 7Kg Scorpio 2Kg Squama Manis 3Kg Scolopendra 3Kg Radix Glycyrrhizae 6Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, specification with 0.5 gram/ball incapsulates, and packing into by every bottle 60 ball promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the bottle.

Embodiment 2: in the ratio of Flos Carthami 25kg Radix Achyranthis Bidentatae 20Kg Radix Angelicae Sinensis 20Kg Fructus Toosendan 10Kg Semen Persicae 20Kg Scorpio 8Kg Squama Manis 9Kg Scolopendra 9Kg Radix Glycyrrhizae 30Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, with the specification of the 3 gram/bags plastic bag of packing into, packing into by the specification of 60 bags in every box promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the box.

Embodiment 3: in the ratio of Flos Carthami 10kg Radix Achyranthis Bidentatae 10Kg Radix Angelicae Sinensis 10Kg Fructus Toosendan 5Kg Semen Persicae 10Kg Scorpio 3Kg Squama Manis 5Kg Scolopendra 5Kg Radix Glycyrrhizae 15Kg, take by weighing the ratio of said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, specification with 0,5 gram/balls incapsulates, and packing into by the specification of every bottle 60 ball gets final product in the bottle.

Embodiment 4: in the ratio of Flos Carthami 15Kg Radix Achyranthis Bidentatae 15Kg Radix Angelicae Sinensis 15Kg Fructus Toosendan 7Kg Semen Persicae 15Kg Scorpio 4Kg Squama Manis 6Kg Scolopendra 6Kg Radix Glycyrrhizae 20Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, with the specification of the 3 gram/bags plastic bag of packing into, packing into by the specification of 60 bags in every box gets final product in the box.

Embodiment 5: in the ratio of Flos Carthami 20Kg Radix Achyranthis Bidentatae 17Kg Radix Angelicae Sinensis 18Kg Fructus Toosendan 8Kg Semen Persicae 17Kg Scorpio 6Kg Squama Manis 7Kg Scolopendra 7Kg Radix Glycyrrhizae 25Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, specification with 0.5 gram/ball incapsulates, and packing into by every bottle 60 ball promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the bottle.

Embodiment 6: in the ratio of Flos Carthami 20Kg Radix Achyranthis Bidentatae 10Kg Radix Angelicae Sinensis 20Kg Fructus Toosendan 10Kg Semen Persicae 20Kg Scorpio 8Kg Squama Manis 8Kg Scolopendra 8Kg Radix Glycyrrhizae 30Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, with the specification of the 3 gram/bags plastic bag of packing into, packing into by the specification of 60 bags in every box promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the box.

Embodiment 7: in the ratio of Flos Carthami 20Kg Radix Achyranthis Bidentatae 20Kg Radix Angelicae Sinensis 10Kg Fructus Toosendan 10Kg Semen Persicae 20Kg Scorpio 8Kg Squama Manis 9Kg Scolopendra 9Kg Radix Glycyrrhizae 30Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, with the specification of the 3 gram/bags plastic bag of packing into, packing into by the specification of 60 bags in every box promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the box.

Embodiment 8: in the ratio of Flos Carthami 10Kg Radix Achyranthis Bidentatae 15Kg Radix Angelicae Sinensis 20Kg Fructus Toosendan 5Kg Semen Persicae 20Kg Scorpio 8Kg Squama Manis 4Kg Scolopendra 4Kg Radix Glycyrrhizae 20Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, with the specification of the 3 gram/bags plastic bag of packing into, packing into by the specification of 60 bags in every box promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the box.

Embodiment 9: in the ratio of Flos Carthami 20Kg Radix Achyranthis Bidentatae 20Kg Radix Angelicae Sinensis 15Kg Fructus Toosendan 3Kg Semen Persicae 15Kg Scorpio 2Kg Squama Manis 3Kg Scolopendra 8Kg Radix Glycyrrhizae 20Kg, take by weighing said medicine exactly, be ground into powder with pulverizer behind the mix homogeneously, cross 80 order dusting covers, specification with 0.5 gram/ball incapsulates, and packing into by every bottle 60 ball promptly becomes a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion of the present invention in the bottle.

Claims (3)

1, a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion is characterized in that it is made by weight by following Chinese crude drug:

Flos Carthami 5-25 part Radix Achyranthis Bidentatae 7-20 part Radix Angelicae Sinensis 6-20 part Fructus Toosendan 3-10 part Semen Persicae 7-20 part Scorpio 2-8 part Squama Manis 3-9 part Scolopendra 3-9 part Radix Glycyrrhizae 6-30 part

2, a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion according to claim 1 is characterized in that it is made by weight by following Chinese crude drug:

Flos Carthami 10-20 part Radix Achyranthis Bidentatae 10-17 part Radix Angelicae Sinensis 10-18 part Fructus Toosendan 5-8 part

Semen Persicae 10-17 part Scorpio 3-6 part Squama Manis 5-7 part Scolopendra 5-7 part Radix Glycyrrhizae 15-25 part

3, a kind of Chinese medicine for the treatment of lumbar intervertebral disc protrusion according to claim 1 is characterized in that it is made by weight by following Chinese crude drug:

20 parts in 6 portions of Radix Glycyrrhizaes of 6 parts of Scolopendras of 4 parts of Squama Maniss of 15 portions of Scorpios of 7 parts of Semen Persicaes of 15 parts of Fructus Toosendans of 15 parts of Radix Angelicae Sinensis of 15 parts of Radix Achyranthis Bidentataes of Flos Carthami