CN103919829A - 一种高油酸红花油的软胶囊 - Google Patents
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Abstract
本发明提供的一种高油酸红花油的软胶囊,将红花籽粉碎、过筛40目制备：向粉碎的红花籽中加入150U/g纤维素酶，其酶底比为2%，再置于载有蒸馏水的容器中，其料液比为1:6，在48-53℃下，酶解2.8-3.2h后，将混合酶解物置于超临界CO2萃取装置中，加热至35℃萃取，萃取压力30MPa，萃取剂流量与试料比为16LCO2/h，萃取时间120min，分离得红花籽油；红花油软胶囊制备：取红花籽油100ml，用VE1-2g与VC1-2g调配，采用全自动胶囊灌装机制得高油酸红花油软胶囊。按500mg/粒×200粒/瓶包装，口服早晚各一次，一次500mg。
Description
技术领域
本发明涉及软胶囊的制备，选用的水酶法结合超临界CO2萃取技术制备软胶囊，不仅提油率高,营养价值也极高。
背景技术
新疆红花，具有很高的经济价值和药用价值。红花籽，即红花种子，中药称“白平子”。红花籽中的亚油酸含量高达81%以上，维生素E含量每100克约为1000毫克，黄铜含量每100克约为628毫克，氨基酸的含量高达11.01%，其中赖氨酸的含量为大枣的19倍，为菠菜的5倍。微量元素的含量也极为丰富，其中钾的含量为苹果的16倍，为大白菜的9倍。红花籽中的不和饱酸和脂肪酸是高血压、高血脂、动脉硬化、冠心病的克星。研究结果显示，长期食用红花籽油，具有降血压、降脂、软化血管的作用，可以稳定血压，增强体质，促进微循环，间接恢复神经功能，降低胆固醇，可预防心血管的发病率，特别对高血压、高血脂、动脉硬化、老年肥胖症等防治极有利。
本发明的高油酸红花油软胶囊，在传统提油的基础上采用水酶法与超临界CO2萃取技术相结合的方式，精心制造，使得红花籽油的出油率和亚油酸含量最大限度地提高，同时提高了产品的质量与保健功效。
发明内容
本发明的目的在于：制得的高油酸红花油软胶囊，有效预防高血脂、高胆固醇引发的高血压，动脉硬化等疾病，深受消费者的青睐。
本发明的目的是这样实现的：一种高油酸红花油的软胶囊,分步骤实施；
原料：将红花籽粉碎、过筛40目，备用；
制备：向粉碎的红花籽中加入150U/g纤维素酶，其酶底比为2%，再置于载有蒸馏水的容器中，其料液比为1:6，在48-53℃下，酶解2.8-3.2h后，将混合酶解物置于超临界CO2萃取装置中，加热至35℃萃取，萃取压力30MPa，萃取剂流量与试料比为16LCO2/h，萃取时间120min，分离得红花籽油；
制备红花油软胶囊：取红花籽油100ml，用VE1-2g与VC1-2g调配，采用全自动胶囊灌装机制得高油酸红花油软胶囊。
本发明的营养作用：提供的高油酸红花油软胶囊为多种活性物质的有机结合，测定出高油酸红花油软胶囊中含有油酸83.1%，黄酮II，黄酮III（以芦丁计）≥0.5(mg/100ml)，富含17种氨基酸，此外还含有一定量的B族维生素及其他的多种营养成份，适宜血脂较高人群，具有软化血管，抗疲劳等功效，彰显技术进步。
具体实施方式
以下结合实施例对发明作进一步说明。
实施例
采用的高油酸红花油软胶囊工艺流程：红花籽→粉碎→过筛→酶解→超临界CO2萃取（加压泵、CO2、补充CO）→分离→红花籽油→胶囊配方→无菌灌装→检验→成品。
1）原料预处理：将红花籽粉碎、过40目筛待用。
2）酶解：向粉碎的红花籽中加入150U/g纤维素酶，其酶底比为2%，再置于载有蒸馏水的容器中，其料液比为1:6，在温度为50℃的条件下，酶解,3h。
3）超临界CO2萃取：将红花籽酶解混合物装入萃取器中，开动循环冷却器、预热器、及加热器使系统达到制定的工作状态；开启CO2钢瓶，CO2由加压泵抽出，经预热器加热到35℃后，进入萃取器，萃取压力为30MPa，萃取剂流量与试料比为16LCO2/h，萃取时间为120min，分离出的物质积累在分离器中。
4）制备胶囊：获得红花籽油后，用VE1.5g/100ml、VC1.5g/100ml调配，采用全自动胶囊灌装机制备成高亚油酸红花油软胶囊。
5）包装：按500mg/粒×200粒/瓶对高亚油酸红花油软胶囊进行包装即为成品。口服：早晚各一次，一次500mg。
产品通过了自治区技术监督局、自治区卫生厅、自治区药检所、昌吉州质量监督检验中心的全项检测，全部指标均符合企业标准Q/XZZ--2010《高油酸红花油软胶囊》的规定。
其中产品指标：
感官指标：黄色透明软胶囊
理化指标：油酸83.1g/100g、总黄酮≥0.67mg/100ml、VE=1.48g/100ml、酸价﹤0.3mgKOH/g、过氧化值﹤10meq/kg、羰基价﹤10meq/kg、VC=1.5g/100ml、黄曲霉毒素B1﹤10μg/kg。
微生物指标：菌落总数＜1(cfu/ml)；大肠菌群＜3(MPN/100ml)；致病菌未检出。（以上各指标均符合国家标准）
所述的制备方法,选用的纤维素酶为南宁宠博生物工程有限公司生产；HL-5+1L/50-ⅢBO超临界CO2流体萃取装置采购于杭州华黎泵业制造有限公司；全自动胶囊灌装机采购于山东青州迈德森制药机械厂。
Claims (2)
1.一种高油酸红花油的软胶囊,其特征在于：分步骤实施；
原料：将红花籽粉碎、过筛40目，备用；
制备：向粉碎的红花籽中加入150U/g纤维素酶，其酶底比为2%，再置于载有蒸馏水的容器中，其料液比为1:6，在48-53℃下，酶解2.8-3.2h后，将混合酶解物置于超临界CO2萃取装置中，加热至35℃萃取，萃取压力30MPa，萃取剂流量与试料比为16LCO2/h，萃取时间120min，分离得红花籽油；
红花油软胶囊制备：取红花籽油100ml，用VE 1-2g与VC 1-2g调配，采用全自动胶囊灌装机制得高油酸红花油软胶囊。
2.依据权利要求1所述软胶囊,其特征在于：按500mg/粒×200粒/瓶包装，口服早晚各一次，一次500mg。
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Cited By (2)
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| CN114272280A (zh) * | 2021-12-30 | 2022-04-05 | 神威药业集团有限公司 | 红花油的提取方法及心脑清软胶囊 |
| WO2025219202A1 (en) * | 2024-04-19 | 2025-10-23 | Bariatek Medical | A fat composition for use in a medical treatment |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272280A (zh) * | 2021-12-30 | 2022-04-05 | 神威药业集团有限公司 | 红花油的提取方法及心脑清软胶囊 |
| WO2023124545A1 (zh) * | 2021-12-30 | 2023-07-06 | 神威药业集团有限公司 | 红花油的提取方法及心脑清软胶囊 |
| WO2025219202A1 (en) * | 2024-04-19 | 2025-10-23 | Bariatek Medical | A fat composition for use in a medical treatment |
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