CN103918659A - Pesticide composite including tolfenpyrad and fluazinam and preparation method and application of pesticide composite - Google Patents

Pesticide composite including tolfenpyrad and fluazinam and preparation method and application of pesticide composite Download PDF

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Publication number
CN103918659A
CN103918659A CN201410144455.0A CN201410144455A CN103918659A CN 103918659 A CN103918659 A CN 103918659A CN 201410144455 A CN201410144455 A CN 201410144455A CN 103918659 A CN103918659 A CN 103918659A
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fluazinam
tolfenpyrad
polyoxyethylene
composition pesticide
investigation
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CN103918659B (en
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邓明学
杨敬勇
邓明娟
韦庆书
韦薇
谭仁景
蓝宏彦
梁永星
谭仁卫
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LIUZHOU HUINONG CHEMICAL CO Ltd
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LIUZHOU HUINONG CHEMICAL CO Ltd
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Abstract

The invention discloses a pesticide composite including tolfenpyrad and fluazinam. The pesticide composite comprises active ingredients and auxiliaries, wherein the active ingredients comprise the following ingredients in parts by weight: 1-30 parts of tolfenpyrad and 1-60 parts of fluazinam. The preparation method comprises the following steps: mixing the active ingredients with the auxiliaries according to the parts by weight, and processing by a convention processing method of the dosage form, thus obtaining the pesticide composite. The pesticide composite can be applied to preventing and treating psylla, citrus red spider, phyllocoptruta oleivora, aphid, citrus gummosis and anthracnose. The pesticide composite provided by the invention can be high in synergism and overcome and delay pest resistance to insecticides, is superior to pesticides with single purpose in control effect, resistant to rainwater washing out, good in fast-acting property, long in lasting period, less in using times and time-saving and labor-saving, and can also prevent and control various injurious insects and diseases, thus reducing the pesticide cost.

Description

A kind of composition pesticide containing Tolfenpyrad and fluazinam and its production and use
Technical field
The invention belongs to pesticide field, be specifically related to a kind of composition pesticide containing Tolfenpyrad and fluazinam and its production and use.
Background technology
Due to single use and the not science, unreasonable of medication of agricultural chemicals, increase the weight of rapidly the resistance of the agricultural chemicals of insect to current use, make some agricultural chemicals new components of expensive, long-time input development shorten service life, access times are many simultaneously, also increased the weight of environmental pollution and increased drug cost.Citrus psylla is unique medium that yellow twig is propagated, and in the situation that have the tender tip the same year, can occur in 1 year 11~14 generations, field generation overlap, and single wood louse passes disease rate up to 70-80%, and adult can fly, and difficulty of prevention and cure is high.Simultaneously; at each growth period of oranges and tangerines; except wood louse; when also having the diseases such as insect pest and resin disease (rubber disease), anthracnose such as two spotted spider mite, blister mite, leaf miner, aleyrodid, occur; so in the urgent need to exploitation compound pesticide composition; the synergistic effect that utilizes two kinds of active component mixtures to produce; improve preventive effect, reduce active ingredient usage amount; accomplish that a medicine is multiplex, double simultaneous multiple insect pest, the disease controlled once; cost-saving; reduce medication number of times, protection of the environment, delay insect, the drug-fast generation of evil mite.
Tolfenpyrad, english common name clothianidin, chemical name (E)-1-(2-chloro-1,3-thiazole-5-ylmethyl)-3-methyl-2-2-nitroguanidine, it is a kind of insecticide in anabasine, be the novel pesticide of a class highly effective and safe, high selectivity, its effect is similar with nAChR, have tag, stomach toxicity and systemic activity.Be mainly used on paddy rice, vegetables, fruit tree and other crops anti-ly eliminating aphis, the insecticide of Semiptera, coleoptera, diptera and some Lepidoptera class pest such as leafhopper, thrips, plant hopper, there is efficient, wide spectrum, consumption is few, toxicity is low, the drug effect lasting period long, to crop without poisoning, use safety, with conventional pesticide without advantages such as cross resistances, having remarkable interior suction and osmosis, is the another kind that substitutes high malicious organophosphorous pesticide.Its novel structure, special, performance is more excellent compared with traditional nicotinic insecticide.
Fluazinam; english common name fluazinam; the chloro-N-of chemical name 3-(the chloro-5-trifluoromethyl-2-of 3-pyridine radicals)-α, α, α-tri-fluoro-2; 6-dinitro-ρ-toluidines; belonging to 2,6-dinitroanilines, is prevention protective fungicide; prevention in advance can guarantee that fruit, quality of vegetable are good, is mainly used in preventing and treating the diseases such as shot hole on downy mildew, gray mold, anthracnose and the fruit tree on vegetables, anthracnose, scab.
At present, we not yet find Patents and the bibliographical information of the composition pesticide of Tolfenpyrad and fluazinam.
Summary of the invention
Object of the present invention solves the problems of the technologies described above, a kind of composition pesticide containing Tolfenpyrad and fluazinam is provided, can overcome and delay that pest resistance to insecticide, preventive effect are better than single dose, resistance of rainwater washing against, quick-acting is good, the lasting period is long, reduce access times, save time, laborsaving, can prevent and treat various pests and disease simultaneously, reduce drug cost.
For realizing above-mentioned object, technical scheme of the present invention is:
Containing a composition pesticide for Tolfenpyrad and fluazinam, comprise active component and auxiliary agent, described active component is Tolfenpyrad and fluazinam;
Described active component is counted by weight:
Tolfenpyrad 1-30 part
Fluazinam 1-60 part.
As further illustrating, the parts by weight that described auxiliary agent adds are:
Dispersant 0.1-15 part
Emulsifier 0.1-12 part
Antifreezing agent 0.1-4 part
Thickener 0.1-4 part
Defoamer 0.1-2 part
Solvent 30-94.8 part
Wetting agent 0.1-15 part
Disintegrant 0.1-6 part
Filler 12-92.3 part;
Wherein, suitable emulsifier is one or more in calcium dodecyl benzene sulfonate, alkylpolyoxyethylene, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, polyoxyethylene nonylphenol ether phosphate, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether, dodecyl polyoxyethylene sulfonate sodium and phenethyl phenol polyethenoxy ether;
Suitable solvent is one or more in dimethylbenzene, diesel oil, toluene, cyclohexanol, methyl alcohol, vegetable oil, turpentine oil, methyl oleate, solvent naphtha, dimethyl formamide, ethanol, N-pyrrolidones, ethyl acetate and aqueous solvent;
Suitable wetting agent is lauryl sodium sulfate, calcium dodecyl benzene sulfonate, methyl naphthalene sulfonate formaldehyde condensate, pull open one or more in powder, alkylnaphthalene sulfonate and spaonin powder;
Suitable dispersant is one or more in sodium lignin sulfonate, calcium lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, polycarboxylate, aliphatic amine polyoxyethylene ether and polyoxyethylene fatty acid glyceride;
Suitable antifreezing agent is one or more in ethylene glycol, propane diols, glycerine and urea;
Suitable thickener is one or more in xanthans, Magnesiumaluminumsilicate, CMC and polyvinyl alcohol;
Suitable defoamer is one or more in silicone oil, C8-10 aliphatic alcohols compound and C10-20 saturated fat acid compounds;
Suitable disintegrant is one or more in bentonite, ammonium sulfate, sodium bicarbonate, aluminium chloride and succinic acid;
Suitable filler is one or more in white carbon, kaolin, diatomite, precipitated calcium carbonate and starch.
As further illustrating, the formulation of described composition pesticide is suspending agent, aqueous emulsion, water dispersible granules, microemulsion or wetting powder.
The preparation method of the composition pesticide containing Tolfenpyrad and fluazinam as above, it is that active component and auxiliary agent are mixed by weight, can obtain by the conventional machining mode of its formulation.
The purposes of the composition pesticide containing Tolfenpyrad and fluazinam as above, it is the application in control mandarin tree wood louse, two spotted spider mite, blister mite, aphid, resin disease, anthracnose.
Component of the present invention is commercially available prod.
Compared with prior art, the beneficial effect that the present invention has is:
1. the novel pyrazole heterocyclic insecticidal/acaricidal agent of Tolfenpyrad Shi Yuan Mitsubishi of the present invention chemical company exploitation, its main mechanism is the oxidative phosphorylation of control insect, also has ovicidal, presses down food, oviposition deterrence and bactericidal action.There is efficient, wide spectrum, consumption is few, toxicity is low, the drug effect lasting period long, to crop without poisoning, use safety, with conventional pesticide without advantages such as cross resistances.Fluazinam effect is better than GPF (General Protection False bactericide.Non-resistant, the lasting period is long, reduces medication number of times, saves time, laborsaving, and without cross resistance, resistance of rainwater washing against, to people, animal, natural enemy and Environmental security with other medicaments.Itself is defined as bactericide fluazinam, and a lot of diseases on fruit and vegetables are all had to good control efficiency.But we are through overtesting, to find citrus red mite, blister mite also has good preventive effect.
2. composition pesticide of the present invention is the combination of desinsection and bactericide, can produce higher synergistic effect, overcome and delayed that pest resistance to insecticide, preventive effect are better than single dose, resistance of rainwater washing against, quick-acting is good, the lasting period is long, reduce access times, save time, laborsaving, can prevent and treat various pests and disease simultaneously, reduce drug cost.The present invention is to the insect in agricultural, especially go up mandarin tree wood louse, two spotted spider mite, blister mite, aphid, resin disease (rubber disease), anthracnose are had to obvious synergistic effect, to other insect on the crop such as paddy rice, vegetables, as the diseases such as leafhopper, thrips, plant hopper, downy mildew, gray mold also have good control efficiency.
embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to the scope that embodiment represents.
Embodiment 1:50% fluazinam Tolfenpyrad suspending agent
Tolfenpyrad 20g
Fluazinam 30g
Sodium lignin sulfonate 1.5g
Calcium dodecyl benzene sulfonate 6g
Aliphatic amine polyoxyethylene ether 2g
Ethylene glycol 3g
Magnesiumaluminumsilicate 0.1g
Silicone oil 2g
Water 35.4g
Embodiment 2:8% fluazinam Tolfenpyrad suspending agent
Tolfenpyrad 4g
Fluazinam 4g
Methyl naphthalene sulfonate formaldehyde condensate 2g
Alkylpolyoxyethylene 3g
Alkylnaphthalene sulfonate 1g
Urea 4g
Aluminium-magnesium silicate 0.2g
C8-10 aliphatic alcohols compound 0.1g
Water 81.7g
Embodiment 3:60% fluazinam Tolfenpyrad suspending agent
Tolfenpyrad 25g
Fluazinam 35g
Styrylphenol polyoxyethylene ether 2g
Calcium lignosulfonate 1g
Phenethyl phenol APEO 1g
Pull open powder 0.8g
Urea 2g
CMC 2g
C10-20 saturated fat acid compounds 0.2g
Water 31.0g
Embodiment 4:40% fluazinam Tolfenpyrad suspending agent
Tolfenpyrad 10g
Fluazinam 30g
Polyoxyethylene fatty acid glyceride 2g
Alkylphenol polyoxyethylene formaldehyde condensation products sodium sulfate salt 2g
Polyoxyethylene aliphatic alcohol ether 2g
Polyoxyethylene nonylphenol ether 2g
Glycerine 3g
Aluminium-magnesium silicate 2g
Xanthans 0.4g
C10-20 saturated fatty acid 0.3g
Water 46.3g
Embodiment 5:30 % fluazinam Tolfenpyrad suspending agent
Tolfenpyrad 20g
Fluazinam 10g
Calcium lignosulfonate 1g
Dodecyl polyoxyethylene sulfonate sodium 2g
Aliphatic acid polyethenoxy base ester 2g
Urea 1g
Ethylene glycol 1g
Polyvinyl alcohol 4g
C8-10 fatty alcohol 0.3g
Water 59.7g
The preparation method of embodiment 1-5 is: take after raw material according to the proportioning of each embodiment, by raw material, solvent stirring and dissolving, add emulsifier to carry out high speed shear emulsification, make corresponding Tolfenpyrad fluazinam suspension emulsion.
Embodiment 6:40% fluazinam Tolfenpyrad aqueous emulsion
Tolfenpyrad 30g
Fluazinam 10g
Styrylphenol polyoxyethylene ether 2g
Aliphatic acid polyethenoxy base ester 4g
Dodecyl sodium naphthalene sulfonate 1g
Polycarboxylic acids sodium 2g
Ethylene glycol 3g
Dimethylbenzene 10g
Vegetable oil 20g
Water 18g
Embodiment 7:2% fluazinam Tolfenpyrad aqueous emulsion
Tolfenpyrad 1g
Fluazinam 1g
Sodium lignin sulfonate 2g
Polyoxyethylene aliphatic alcohol ether 1g
Calcium dodecyl benzene sulfonate 0.1g
Propane diols 0.1g
Cyclohexanol 10g
Methyl alcohol 5g
Turpentine oil 5g
Water 74.8g
Embodiment 8:60% fluazinam Tolfenpyrad aqueous emulsion
Tolfenpyrad 20g
Fluazinam 40g
Polyoxyethylene fatty acid glyceride 2g
Polyoxyethylene nonylphenol ether 1g
Dodecyl phenol polyethenoxy ether 1g
Phenethyl phenol APEO 3g
Glycerine 3g
Diesel oil 8g
Toluene 3g
Solvent naphtha 8g
Water 11g
Embodiment 9:40% fluazinam Tolfenpyrad aqueous emulsion
Tolfenpyrad 30g
Fluazinam 10g
Alkylphenol polyoxyethylene formaldehyde condensation products sodium sulfate salt 2g
Calcium salt of dodecylbenzene sulfonate 2g
Nonyl phenol polyethenoxy ether 0.1g
Polyoxyethylene fatty acid glyceride 1.9g
Aliphatic amine polyoxyethylene ether 2g
Urea 3g
N-pyrrolidones 0.5g
Ethyl acetate 4g
Vegetable oil 22g
Water 22.5g
Embodiment 10:30 % fluazinam Tolfenpyrad aqueous emulsion
Tolfenpyrad 10g
Fluazinam 20g
Polyoxyethylene fatty acid glyceride 2g
Polyoxyethylene nonylphenol ether phosphate 2g
Aliphatic acid polyethenoxy base ester 1g
Methyl oleate 12g
Ethylene glycol 3g
Urea 1g
Dimethyl formamide 2g
Turpentine oil 2g
Toluene 2.5g
Water 42.5g
The preparation method of embodiment 6-10 is: take after raw material according to the proportioning of each embodiment, by raw material, solvent stirring and dissolving, add emulsifier to carry out high speed shear emulsification, make corresponding fluazinam Tolfenpyrad aqueous emulsion.
Embodiment 11:25% fluazinam Tolfenpyrad water dispersible granules
Tolfenpyrad 10g
Fluazinam 15g
Sodium lignin sulfonate 5g
Polycarboxylate 3g
Calcium dodecyl benzene sulfonate 4 g
Pull open powder 4 g
Ammonium sulfate 5.5g
Starch 10g
Diatomite 43.5g
Embodiment 12:2% fluazinam Tolfenpyrad water dispersible granules
Tolfenpyrad 1g
Fluazinam 1g
Sodium lignin sulfonate 5g
Calcium dodecyl benzene sulfonate 6g
Spaonin powder 4g
Pull open powder 5g
Aluminium chloride 0.1g
Precipitated calcium carbonate 20g
White carbon 20 g
Kaolin 37.9g
Embodiment 13:55% fluazinam Tolfenpyrad water dispersible granules
Tolfenpyrad 15g
Fluazinam 40g
Calcium lignosulfonate 2g
Calcium dodecyl benzene sulfonate 2g
Lauryl sodium sulfate 6g
Bentonite 3g
Sodium bicarbonate 3g
Starch 8g
Precipitated calcium carbonate 20g
Embodiment 14:65% fluazinam Tolfenpyrad water dispersible granules
Tolfenpyrad 5g
Fluazinam 60g
Calcium lignosulfonate 6g
Lauryl sodium sulfate 9g
Sodium lignin sulfonate 4g
Ammonium sulfate 4g
Kaolin 12g
Embodiment 15:40% fluazinam Tolfenpyrad water dispersible granules
Tolfenpyrad 10g
Fluazinam 30g
Calcium dodecyl benzene sulfonate 2g
Styrylphenol polyoxyethylene ether 4g
Calcium lignosulfonate 2g
Bentonite 5g
Diatomite 20g
Precipitated calcium carbonate 27g
The preparation method of embodiment 11-15 is: take after raw material according to the proportioning of each embodiment, by raw material co-grinding, pass through granulation, be dried and make corresponding fluazinam Tolfenpyrad water dispersible granules.
Embodiment 16:30% fluazinam Tolfenpyrad wetting powder
Tolfenpyrad 5g
Fluazinam 25g
Sodium lignin sulfonate 7g
Calcium dodecyl benzene sulfonate 8g
Precipitated calcium carbonate 20g
Kaolin 30g
Embodiment 17:4% fluazinam Tolfenpyrad wetting powder
Fluazinam 2g
Tolfenpyrad 2g
Calcium lignosulfonate 0.1g
Calcium dodecyl benzene sulfonate 2g
Spaonin powder 0.6g
Diatomite 63.3g
Precipitated calcium carbonate 17g
Starch 12g
Embodiment 18:60% fluazinam Tolfenpyrad wetting powder
Tolfenpyrad 20g
Fluazinam 40g
Calcium lignosulfonate 8g
Sodium lignin sulfonate 4g
Pull open powder 0.3g
Succinic acid 3g
Dodecyl sodium naphthalene sulfonate 3g
White carbon 21.7g
Embodiment 19:65% fluazinam Tolfenpyrad wetting powder
Tolfenpyrad 10g
Fluazinam 55g
Spaonin powder 5g
Dodecyl phenol polyethenoxy ether 2g
Polycarboxylic acids sodium 1g
Ammonium sulfate 5g
Starch 4g
Sodium bicarbonate 18g
Embodiment 20:40% fluazinam Tolfenpyrad wetting powder
Tolfenpyrad 10g
Fluazinam 30g
Polycarboxylic acids sodium 8g
Dodecyl naphthalene sulfonate salt 0.1g
Pull open powder 1g
Starch 5g
Diatomite 21.9g
Precipitated calcium carbonate 24g
The preparation method of embodiment 16-20 is: take after raw material according to the proportioning of each embodiment, raw material is mixed to ultramicro grinding, make corresponding fluazinam Tolfenpyrad wetting powder.
Embodiment 21:44% fluazinam Tolfenpyrad microemulsion
Tolfenpyrad 22g
Fluazinam 22g
Sodium lignin sulfonate 4g
Styrylphenol polyoxyethylene ether 5g
Calcium dodecyl benzene sulfonate 8g
Ethylene glycol 3.3g
Dimethylbenzene 5g
Vegetable oil 16g
Water 14.7g
Embodiment 22:10% fluazinam Tolfenpyrad microemulsion
Tolfenpyrad 5g
Fluazinam 5g
Polyoxyethylene nonylphenol ether phosphate 8g
Styrylphenol polyoxyethylene ether 2.4g
Calcium dodecyl benzene sulfonate 4g
Propane diols 0.3g
Cyclohexanol 3g
Methyl alcohol 5g
Turpentine oil 7g
Water 60.3g
Embodiment 23:60% fluazinam Tolfenpyrad microemulsion
Tolfenpyrad 20g
Fluazinam 40g
Polyoxyethylene nonylphenol ether 5g
Polyoxyethylene aliphatic alcohol ether 3g
Methyl naphthalene sulfonate formaldehyde condensate 0.4g
Glycerine 2g
Urea 2g
Diesel oil 6g
Toluene 5g
Turpentine oil 11g
Water 10.6g
Embodiment 24:40% fluazinam Tolfenpyrad microemulsion
Tolfenpyrad 15g
Fluazinam 25g
Alkylphenol polyoxyethylene formaldehyde condensation products sodium sulphate 2g
Calcium salt of dodecylbenzene sulfonate 1g
Polycarboxylic acids sodium 3g
Aliphatic amine polyoxyethylene ether 2g
Urea 4g
N-pyrrolidones 0.8g
Ethyl acetate 4g
Ethanol 20g
Water 23.2g
Embodiment 25:30 % fluazinam Tolfenpyrad microemulsion
Tolfenpyrad 20g
Fluazinam 10g
Polyoxyethylene fatty acid glyceride 2g
Dodecyl polyoxyethylene sodium sulfonate 4g
Aliphatic acid polyethenoxy base ester 5g
Methyl oleate 12g
Ethylene glycol 3g
Dimethyl formamide 2g
Turpentine oil 7g
Water 35g
The preparation method of embodiment 20-25 is: take after raw material according to the proportioning of each embodiment, by raw material, solvent stirring and dissolving, add emulsifier, water to carry out high speed shear, make corresponding fluazinam Tolfenpyrad microemulsion.
Embodiment 26:15% fluazinam Tolfenpyrad missible oil
Tolfenpyrad 5g
Fluazinam 10g
Phenethyl phenol polyethenoxy ether 8g
Aliphatic acid polyethenoxy base ester 4g
Methyl oleate 63g
Cyclohexanone 10g
Embodiment 27:40% fluazinam Tolfenpyrad missible oil
Tolfenpyrad 30g
Fluazinam 10g
Alkylpolyoxyethylene 8g
Polyoxyethylene aliphatic alcohol ether 4g
Turpentine oil 20g
Vegetable oil 18g
Dimethylbenzene 10g
Embodiment 28:55% fluazinam Tolfenpyrad missible oil
Tolfenpyrad 25g
Fluazinam 30g
Alkylpolyoxyethylene 5g
Polyoxyethylene aliphatic alcohol ether 2g
Solvent naphtha 20g
Turpentine oil 10g
Dimethylbenzene 7g
The preparation method of embodiment 26-28 is: take after raw material according to the proportioning of each embodiment, by raw material, solvent stirring and dissolving, then add emulsifier, make corresponding Tolfenpyrad fenbutatin oxide missible oil.
Application Example:
In order to detect the insecticidal effect of composition of the present invention, now enumerate following experimental data:
Application Example 5 result of the tests:
The 30% Tolfenpyrad fluazinam suspending agent that the embodiment of the present invention 5 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, spray-on process, when preparating liquid, adopt double dilution method, evenly spray in oranges and tangerines branch leaf and fruit, carry out dispenser for the first time at the sick their early stage of resin, execute altogether 4 times.Within after last medicine 20 days, investigate, investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 strain trees are investigated in every community, every strain by east, south, west, north, in the sampling of five points, two branches of every some investigation, down 4 leaves and whole fruit of each branch investigation top, several, the sick leaves of total leaf (really) (really) number of record investigation and disease level, calculate disease index and preventive effect.
Table 1 30% Tolfenpyrad fluazinam suspending agent control oranges and tangerines resin diseases (rubber disease) test of pesticide effectiveness result
Chemicals treatment After the 4th medicine, 20 days sick fruits at different levels are investigated preventive effect 20 days sick leaf investigation preventive effects at different levels after the 4th medicine
30% 1500 times of Tolfenpyrad fluazinam suspending agent dilutions 85.47% 92.68%
15% 1000 times of Tolfenpyrad suspending agent dilutions 63.91% 64.69%
500 1500 times of grams per liter fluazinam suspending agent dilutions 72.62% 85.56%
Table 1 result of the test shows, start to execute medicine for the first time at oranges and tangerines resin disease (rubber disease) initial stage of origination, thank spend after setting middle and later periods, young fruit period, fruit growth period respectively execute once again, 30% Tolfenpyrad fluazinam suspending agent control oranges and tangerines resin diseases (rubber disease) have good preventive effect.
Application Example 7
The 2% Tolfenpyrad fluazinam aqueous emulsion that the embodiment of the present invention 7 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dilution by processing dosage and be made into liquid, evenly spray in oranges and tangerines leaf tow sides, contain and send out phase dispenser 1 time oranges and tangerines aphid, dispenser eve investigation insect population radix, each investigation in 1 day, 3 days, 7 days borer population of once surviving after dispenser, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 mandarin trees of every community investigation, every strain by east, south, west, north, in 5 orientation 5 killed tips of investigation, the aphid number of 5 leaves of every tip investigation top tip, calculating relative control effect.
Application Example 7 result of the tests:
Table 2 2% Tolfenpyrad fluazinam aqueous emulsion control oranges and tangerines Control of Aphids result
Chemicals treatment After medicine 1 day After medicine 3 days After medicine 7 days
2% 1000 times of Tolfenpyrad fluazinam aqueous emulsion dilutions 92.32% 98.76% 98.87%
15% 1000 times of Tolfenpyrad suspending agent dilutions 74.56% 76.83% 79.25%
500 1500 times of grams per liter fluazinam suspending agent dilutions 62.62% 73.90% 76.27%
Table 2 result of the test shows, contains and sends out phase dispenser mandarin tree aphid, and 2% Tolfenpyrad fluazinam aqueous emulsion control oranges and tangerines aphid has good preventive effect.
Application Example 15
The 40% Tolfenpyrad fluazinam water dispersible granules that the embodiment of the present invention 15 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dissolved dilution by processing dosage and be made into liquid, the whole strain of mandarin tree is sprayed, take out and send out phase dispenser 1 time at orange young, dispenser eve investigation insect population radix, each investigation in 1 day, 7 days, 15 days borer population of once surviving after dispenser, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, investigation method employing is determined strain and is determined tip investigation, 2 mandarin trees of every community investigation, every strain by east, south, west, north, in 5 different azimuth choose 2 and have the worm tip to carry out mark, the every tip of the investigation records borer population of living.With the comparison of blank district, calculate relative control effect.
Application Example 15 result of the tests:
Table 3 40% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines wood louse test of pesticide effectiveness result
Process After medicine 1 day After medicine 7 days After medicine 15 days
40% 2000 times of Tolfenpyrad fluazinam water-dispersible grain dilution agents 89.12% 96.39% 97.98%
15% 1500 times of Tolfenpyrad suspending agent dilutions 80.70% 85.31% 88.45%
500 1500 times of grams per liter fluazinam suspending agent dilutions 68.42% 79.65% 82.97%
Table 3 result of the test shows, in the phase dispenser of causing harm of mandarin tree wood louse, 40% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines wood louse has good preventive effect.
The 40% Tolfenpyrad fluazinam water dispersible granules that the embodiment of the present invention 15 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dilution by processing dosage and be made into liquid, evenly spray in oranges and tangerines leaf tow sides, contain and send out phase dispenser 1 time oranges and tangerines aphid, dispenser eve investigation insect population radix, each investigation in 1 day, 3 days, 7 days borer population of once surviving after dispenser, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 mandarin trees of every community investigation, every strain by east, south, west, north, in 5 orientation 5 killed tips of investigation, the aphid number of 5 leaves of every tip investigation top tip, calculating relative control effect.
Table 4 40% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines Control of Aphids result
Chemicals treatment After medicine 1 day After medicine 3 days After medicine 7 days
40% 4000 times of Tolfenpyrad fluazinam water-dispersible grain dilution agents 89.47% 92.53% 96.19%
15% 2000 times of Tolfenpyrad suspending agent dilutions 80.48% 84.10% 89.95%
500 3000 times of grams per liter fluazinam suspending agent dilutions 76.17% 78.32% 82.81%
Table 4 result of the test shows, contains and sends out phase dispenser mandarin tree aphid, and 40% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines aphid has good preventive effect.
Application Example 16
The 30% Tolfenpyrad fluazinam wetting powder that the embodiment of the present invention 16 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carries out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dilution by processing dosage and be made into liquid, evenly spray in mandarin tree blade, branch is to moistening, oranges and tangerines blister mite peak of occurrence dispenser in early stage 1 time, dispenser eve investigation mite quantity alive, after dispenser 1 day, 7 days, 10 days, 15 days, once the fix a point mite number remaining alive of leaf of each investigation in 21 days, totally 5 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 mandarin trees of investigation method Wei Mei community investigation, every strain by east, south, west, north, in 5 azimuth mark side shoots, investigate the mite quantity alive of 20 new leaf backs, directly observe the mite number in each visual field with 10 times of collapsible hand-held magnascopes.With the comparison of blank district, calculate relative control effect.
Application Example 16 result of the tests:
Table 5 30% Tolfenpyrad fluazinam wetting powder control oranges and tangerines blister mite test of pesticide effectiveness result
Process After medicine 1 day After medicine 7 days After medicine 10 days After medicine 15 days After medicine 21 days
30% 4000 times of Tolfenpyrad fluazinam wettable powder dilution agents 90.83% 95.27% 98.21% 94.52% 91.3%
15% 2000 times of Tolfenpyrad suspending agent dilutions 79.36% 80.54% 81.28% 79.05% 85.37%
500 2000 times of grams per liter fluazinam suspending agent dilutions 82.96% 85.34% 89.73% 84.51% 83.29%
Table 5 result of the test shows, in the dispenser in early stage of mandarin tree blister mite peak of occurrence, 30% Tolfenpyrad fluazinam wetting powder control oranges and tangerines blister mite has good preventive effect.
The 30% Tolfenpyrad fluazinam wetting powder that the embodiment of the present invention 16 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carries out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dilution by processing dosage and be made into liquid, evenly spray in mandarin tree blade tow sides, limb is to moistening, contain and send out initial stage dispenser 1 time citrus red mite, dispenser eve investigation mite quantity alive, after dispenser 3 days, 10 days, once the fix a point remaining two spotted spider mite quantity of leaf of each investigation in 15 days, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 mandarin trees of investigation method Wei Mei community investigation, tree crown by east, south, west, north, in treetop branch of 5 each marks in orientation, investigate 5 blades that every tip pushes up most, investigate altogether remaining two spotted spider mite quantity on 25 blades, directly observe the mite number in each visual field with 10 times of collapsible hand-held magnascopes.With the comparison of blank district, calculate relative control effect.
Table 6 30% Tolfenpyrad fluazinam wetting powder control citrus red mite test of pesticide effectiveness result
Process After medicine 3 days After medicine 10 days After medicine 15 days
30% 4000 times of Tolfenpyrad fluazinam wettable powder dilution agents 96.12% 99.01% 98.46%
15% 2000 times of Tolfenpyrad suspending agent dilutions 74.31% 82.92% 75.34%
500 2000 times of grams per liter fluazinam suspending agent dilutions 82.94% 86.78% 88.96%
Table 6 result of the test shows, contains and sends out initial stage dispenser citrus red mite, and 30% Tolfenpyrad fluazinam wetting powder control citrus red mite has good preventive effect.
Application Example 22
The 10% Tolfenpyrad fluazinam microemulsion that the embodiment of the present invention 22 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dissolved dilution by processing dosage and be made into liquid, the whole strain of mandarin tree is sprayed, take out and send out phase dispenser 1 time at orange young, dispenser eve investigation insect population radix, each investigation in 5 days, 10 days, 15 days borer population of once surviving after dispenser, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, investigation method employing is determined strain and is determined tip investigation, 2 mandarin trees of every community investigation, every strain by east, south, west, north, in 5 different azimuth choose 2 and have the worm tip to carry out mark, the every tip of the investigation records borer population of living.With the comparison of blank district, calculate relative control effect.
Application Example 22 result of the tests:
Table 7 10% Tolfenpyrad fluazinam microemulsion control oranges and tangerines wood louse test of pesticide effectiveness result
Process After medicine 5 days After medicine 10 days After medicine 15 days
10% 2000 times of Tolfenpyrad fluazinam microemulsion dilutions 95.37% 97.15% 97.06%
15% 1000 times of Tolfenpyrad suspending agent dilutions 82.84% 86.55% 85.74%
500 1500 times of grams per liter fluazinam suspending agent dilutions 77.47% 79.95% 81.67%
Table 7 result of the test shows, in the phase dispenser of causing harm of mandarin tree wood louse, 10% Tolfenpyrad fluazinam microemulsion control oranges and tangerines wood louse has good preventive effect.
Application Example 6
The 40% Tolfenpyrad fluazinam aqueous emulsion that the embodiment of the present invention 6 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, adopt spray-on process, when preparating liquid, adopt double dilution method, evenly spray in oranges and tangerines branch leaf and fruit, carry out dispenser for the first time at the sick their early stage of resin, execute altogether 4 times, after each medicine, each investigation in 20 days once.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 strain trees are investigated in every community, every strain by east, south, west, north, in the sampling of five points, two branches of every some investigation, down 4 leaves and whole fruit of each branch investigation top, several, the sick leaves of total leaf (really) (really) number of record investigation and sick level, calculate disease index and preventive effect.
Application Example 6 result of the tests:
Table 8 40% Tolfenpyrad fluazinam aqueous emulsion oranges and tangerines resin diseases (rubber disease) test of pesticide effectiveness result
Process After the 4th medicine, 20 days sick fruits at different levels are investigated preventive effect 20 days sick leaf investigation preventive effects at different levels after the 4th medicine
40% 2500 times of Tolfenpyrad fluazinam aqueous emulsion dilutions 85.86% 87.57%
15% 1500 times of Tolfenpyrad suspending agent dilutions 71.28% 75.58%
500 1000 times of grams per liter fluazinam suspending agent dilutions 75.72% 82.68%
Table 8 result of the test shows, start to execute medicine for the first time at oranges and tangerines resin disease (rubber disease) initial stage of origination, thank spend after setting middle and later periods, young fruit period, fruit growth period respectively execute once again, 40% Tolfenpyrad fluazinam aqueous emulsion control oranges and tangerines resin diseases (rubber disease) have good preventive effect.
The 40% Tolfenpyrad fluazinam aqueous emulsion that the embodiment of the present invention 6 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carries out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, adopt spray-on process, when preparating liquid, adopt double dilution method, evenly spray in oranges and tangerines branch leaf and fruit, carry out dispenser for the first time at citrus anthracnose their early stage or premorbid, execute altogether 3 times, 10 days, dispenser interval, after each medicine, within 15 days, carry out single-round survey, investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community.
Blade disease survey method: 2 strains trees are investigated in every community, every strain by east, south, west, north, in five somes samplings, whole blades of two tips of every some investigation, total leaf tree of record investigation, sick leaf tree and sick level, calculate disease index and preventive effect.
Fruit disease investigation method: two strain mandarin trees are investigated in every community, 100 fruits of every strain random searching, total fruit tree of record investigation and sick fruit number, calculate diseased fruit rate and preventive effect.
Application Example 6 result of the tests:
Table 9 40% Tolfenpyrad fluazinam aqueous emulsion citrus anthracnose test of pesticide effectiveness result
Process After last medicine, 15 days sick fruits at different levels are investigated preventive effect 15 days sick leaf investigation preventive effects at different levels after last medicine
40% 2000 times of Tolfenpyrad fluazinam aqueous emulsion dilutions 86.89% 88.67%
15% 1500 times of Tolfenpyrad suspending agent dilutions 71.38% 73.95%
500 1500 times of grams per liter fluazinam suspending agent dilutions 75.54% 80.21%
Table 9 result of the test shows, carries out dispenser for the first time at citrus anthracnose their early stage or premorbid, and young fruit period, fruit growth period are respectively executed once again, and 40% Tolfenpyrad fluazinam aqueous emulsion control citrus anthracnose has good preventive effect.
Application Example 11
The 25% Tolfenpyrad fluazinam water dispersible granules that the embodiment of the present invention 11 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carries out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dilution by processing dosage and be made into liquid, evenly spray in mandarin tree blade, branch is to moistening, oranges and tangerines blister mite peak of occurrence dispenser in early stage 1 time, dispenser eve investigation mite quantity alive, after dispenser 1 day, 7 days, 14 days, 21 days, once the fix a point mite number remaining alive of leaf of each investigation in 28 days, totally 5 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 mandarin trees of investigation method Wei Mei community investigation, every strain by east, south, west, north, in 5 azimuth mark side shoots, investigate the mite quantity alive of 20 new leaf backs, directly observe the mite number in each visual field with 10 times of collapsible hand-held magnascopes.With the comparison of blank district, calculate relative control effect.
Application Example 11 result of the tests:
Table 10 25% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines blister mite test of pesticide effectiveness result
Process After medicine 1 day After medicine 7 days After medicine 14 days After medicine 21 days After medicine 28 days
25% 4000 times of Tolfenpyrad fluazinam water-dispersible grain dilution agents 92.06% 95.16% 95.32% 94.78% 90.46%
15% 2000 times of Tolfenpyrad suspending agent dilutions 74.81% 78.24% 76.57% 77.26% 68.38%
500 2000 times of grams per liter fluazinam suspending agent dilutions 83.12% 83.97% 85.52% 82.49% 80.87%
Table 10 result of the test shows, in the dispenser in early stage of mandarin tree blister mite peak of occurrence, 25% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines blister mite has good preventive effect.
Application Example 26
The 15% Tolfenpyrad fluazinam water dispersible granules that the embodiment of the present invention 26 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, foliar spray method, be watered dissolved dilution by processing dosage and be made into liquid, the whole strain of mandarin tree is sprayed, take out and send out phase dispenser 1 time at orange young, dispenser eve investigation insect population radix, each investigation in 5 days, 10 days, 15 days borer population of once surviving after dispenser, totally 3 times.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, investigation method employing is determined strain and is determined tip investigation, 2 mandarin trees of every community investigation, every strain by east, south, west, north, in 5 different azimuth choose 2 and have the worm tip to carry out mark, the every tip of the investigation records borer population of living.With the comparison of blank district, calculate relative control effect.
Application Example 15 result of the tests:
Application Example 26 result of the tests
Table 11 15% Tolfenpyrad fluazinam EC oranges and tangerines wood louse test of pesticide effectiveness result
Process After medicine 5 days After medicine 10 days After medicine 15 days
15% 2000 times of fluazinam Tolfenpyrad missible oil dilutions 93.16% 96.88% 97.10%
15% 1000 times of Tolfenpyrad suspending agent dilutions 83.34% 85.92% 85.89%
500 1500 times of grams per liter fluazinam suspending agent dilutions 76.87% 80.25% 82.37%
Table 11 result of the test shows, in the phase dispenser of causing harm of mandarin tree wood louse, 40% Tolfenpyrad fluazinam water dispersible granules control oranges and tangerines wood louse has good preventive effect.
Application Example 27
The 40% fluazinam clothianidin missible oil that the embodiment of the present invention 6 is obtained and 500 grams per liter fluazinam suspending agents, 15% Tolfenpyrad suspending agent carry out field control effectiveness test, test site is mono-group of navel orange orchard of land-reclaimable Guilin Liang Feng, Guangxi, Guilin City, adopt spray-on process, when preparating liquid, adopt double dilution method, evenly spray in oranges and tangerines branch leaf and fruit, carry out dispenser for the first time at the sick their early stage of resin, execute altogether 4 times, within after last medicine 20 days, investigate.Investigation area is calculated (every community is as 2 ~ 3 strain mandarin trees) taking community, 2 strain trees are investigated in every community, every strain by east, south, west, north, in the sampling of five points, two branches of every some investigation, down 4 leaves and whole fruit of each branch investigation top, several, the sick leaves of total leaf (really) (really) number of record investigation and sick level, calculate disease index and preventive effect.
Application Example 27 result of the tests
Table 12 40% Tolfenpyrad fluazinam EC oranges and tangerines resin diseases (rubber disease) test of pesticide effectiveness result
Process After the 4th medicine, 20 days sick fruits at different levels are investigated preventive effect 20 days sick leaf investigation preventive effects at different levels after the 4th medicine
40% 2500 times of fluazinam Tolfenpyrad missible oil dilutions 86.34% 87.95%
15% 1500 times of Tolfenpyrad suspending agent dilutions 69.88% 74.16%
500 1000 times of grams per liter fluazinam suspending agent dilutions 75.46% 80.51%
Table 12 result of the test shows, start to execute medicine for the first time at oranges and tangerines resin disease (rubber disease) initial stage of origination, thank spend after setting middle and later periods, young fruit period, fruit growth period respectively execute once again, 40% Tolfenpyrad fluazinam EC oranges and tangerines resin diseases (rubber disease) have good preventive effect.
The synergistic effect of following instance explanation composition
The Toxicity Determination of composition pesticide to oranges and tangerines wood louse
Subjects is oranges and tangerines wood louse.
Test adopts medicine embrane method.Get cylindrical clear glass Cans (base diameter 6.8cm, bottleneck diameter 5.5cm, high 8.7cm), add 50ml to be diluted to the liquid of desired concn, cover tightly lid, shake up gently, be inverted 30s, make bottle inwall all stick liquid, then liquid is poured out, then allow bottle naturally dry.Oranges and tangerines tender shoots is soaked to 1min with identical liquid, after naturally drying, put into the bottle having dried; Encase the moisturizing of tender shoots base portion with the cotton of soaking identical liquid.Wood louse adult gathers from kamuning tree with band plug teat glass.Each processing repeats 3 times, repeats 10 adults at every turn.When processing, process bottle with putting into each after co2 anesthesia (18-20s), blank clear water, each bottleneck is built with 40 order gauzes, in case adult flies out.After 20 minutes, check whether there is dead worm, record the front borer population of living of medicine.To connect vial after worm and be placed in the illumination box of temperature (25 ± 1) DEG C.After medicine, 24h estimates dead borer population, worm worm alive, calculates lethality, and clear water contrast lethality is no more than 10% for efficiency test.
First concentration conversion is become to natural logrithm value, corrected mortality is converted into arcsine transformation value.Taking arcsine transformation value as dependent variable, taking dosage natural logrithm value as independent variable, carry out linear regression analysis by DPS Biological Statistic Analysis Software again, draw the toxicity regression linear equation of each medicament.Calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index=standard medicament EC50/ reagent agent EC50 × 100
The content of single dose theoretical toxicity index=single dose actual measurement toxicity index × single dose in mixture
The theoretical toxicity index sum of mixture theoretical toxicity index=each single dose
Theoretical toxicity index × 100 of toxicity index/mixture of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 < CTC < 120 are summation action, CTC >=120 are synergistic effect.
Table 5: the co-toxicity coefficient of the toxicity index of each medicament and Tolfenpyrad fluazinam
Reagent agent Proportioning EC 50(mg/kg) Co-toxicity coefficient
Tolfenpyrad -- 6.79 -
Fluazinam -- 4.64 -
Tolfenpyrad: fluazinam 1:50 3.21 145.45
Tolfenpyrad: fluazinam 1:40 2.97 157.44
Tolfenpyrad: fluazinam 1:30 2.58 181.70
Tolfenpyrad: fluazinam 1:15 2.34 202.29
Tolfenpyrad: fluazinam 1:1 2.78 198.30
Tolfenpyrad: fluazinam 5:1 3.33 189.28
Tolfenpyrad: fluazinam 10:1 3.61 180.49
Tolfenpyrad: fluazinam 15:1 4.32 152.76
Tolfenpyrad: fluazinam 20:1 4.53 146.66
Table 5 shows Tolfenpyrad and fluazinam, and 1:50~20:1 is composite in mass ratio, oranges and tangerines wood louse is all had to synergistic effect, and when especially proportioning is between 1:40~15:1, synergy is more remarkable, co-toxicity coefficient is all greater than 150, is far longer than the evaluation criterion 120 of synergistic effect.
The Toxicity Determination of composition of the present invention to citrus red mite:
The slide infusion process that test adopts FAO (Food and Agriculture Organization of the United Nation) (FAO) to recommend.The female one-tenth mite of 20 work of every slide inoculation, the row concentration value of setting up departments on the basis of 3 preliminary experimenies, clear water contrast, every processing repeats (totally 60 female one-tenth mites) 3 times.After soaking 5 seconds of medicine, blot with blotting paper immediately, then put into 24-26 DEG C of insulating box, within after medicine 48 hours, check lethality, calculation correction lethality.Concentration conversion is become to natural logrithm value, corrected mortality is converted into arcsine transformation value, then taking arcsine transformation value as dependent variable, taking dosage natural logrithm value as independent variable, carry out linear regression analysis by DPS Biological Statistic Analysis Software, draw the toxicity regression linear equation of each medicament.Obtain corrected mortality arcsine transformation value (y) according to the toxicity regression linear equation of each medicament, draw EC50 value by looking into antilogarithm table, then calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index=standard medicament EC50/ reagent agent EC50 × 100
The content of single dose theoretical toxicity index=single dose actual measurement toxicity index × single dose in mixture
The theoretical toxicity index sum of mixture theoretical toxicity index=each single dose
Theoretical toxicity index × 100 of toxicity index/mixture of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 < CTC < 120 are summation action, and CTC >=120 are synergistic effect, and experimental result please refer to table 6:
Table 6: the co-toxicity coefficient of the toxicity index of each medicament and Tolfenpyrad fluazinam
Reagent agent Proportioning EC 50(mg/kg) Co-toxicity coefficient
Tolfenpyrad -- 7.21 -
Fluazinam -- 4.73 -
Tolfenpyrad: fluazinam 1:50 3.08 154.61
Tolfenpyrad: fluazinam 1:40 2.87 166.20
Tolfenpyrad: fluazinam 1:30 2.52 189.81
Tolfenpyrad: fluazinam 1:15 2.26 213.88
Tolfenpyrad: fluazinam 1:1 2.76 206.97
Tolfenpyrad: fluazinam 5:1 3.29 201.54
Tolfenpyrad: fluazinam 10:1 3.63 189.58
Tolfenpyrad: fluazinam 15:1 4.59 152.10
Tolfenpyrad: fluazinam 20:1 4.77 147.47
The experimental result of table 6 shows Tolfenpyrad and fluazinam, and 1:50~20:1 is composite in mass ratio, and citrus red mite is all had to synergistic effect, and when especially proportioning is between 1:50~15:1, synergy is more remarkable.
The Toxicity Determination of composition of the present invention to oranges and tangerines resin disease (broken skin disease):
Test adopts mycelial growth rate method, getting experiment liquid that 5ml prepares joins the hot medium of 45ml (PDA medium is housed, 45-50 DEG C) conical flask in, after shaking up, pour rapidly diameter 90mm glass culture dish into, each culture dish is poured band medicine medium 12ml, 4 repetitions of each processing into, level leaves standstill, after cooling flat board.Try bacterium edge with diameter 5mm card punch from the confession of cultivation 4d and cut bacterium cake, will receive and be with on malicious medium with the one side of mycelia with choosing pin, all operations all carries out sterile working at superclean bench.After processing, flat board is placed on after cultivating 4d in the constant temperature aseptic culture case of 20 DEG C and adopts right-angled intersection method to measure respectively the colony diameter of each processing, calculate the mean value of each processing colony diameter, average net growth and the mycelial growth inhibition rate of colony diameter.
Bacterium colony net growth (mm)=colony diameter-5
Mycelial growth inhibition rate (%)=((contrast bacterium colony net growth-processing bacterium colony net growth)/contrast bacterium colony net growth) × 100
Concentration conversion is become to natural logrithm value, and inhibiting rate conversion arcsin function value, taking arcsine letter replacement value as dependent variable, taking dosage natural logrithm value as independent variable, carry out linear regression analysis by DPS Biological Statistic Analysis Software, draw regression equation, then carry out anti-natural logrithm and convert and draw EC50.Calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index=standard medicament EC50/ reagent agent EC50 × 100
The content of single dose theoretical toxicity index=single dose actual measurement toxicity index × single dose in mixture
The theoretical toxicity index sum of mixture theoretical toxicity index=each single dose
Theoretical toxicity index × 100 of toxicity index/mixture of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 < CTC < 120 are summation action, and CTC >=120 are synergistic effect, and experimental result please refer to table 5;
Table 7: the co-toxicity coefficient of the toxicity index of each medicament and Tolfenpyrad fluazinam
Reagent agent Proportioning EC 50(mg/kg) Co-toxicity coefficient
Tolfenpyrad - 8.43 -
Fluazinam - 5.91 -
Tolfenpyrad: fluazinam 1:50 3.94 150.88
Tolfenpyrad: fluazinam 1:40 3.59 165.83
Tolfenpyrad: fluazinam 1:30 3.22 185.33
Tolfenpyrad: fluazinam 1:15 2.96 203.46
Tolfenpyrad: fluazinam 1:1 3.26 213.16
Tolfenpyrad: fluazinam 5:1 3.83 205.49
Tolfenpyrad: fluazinam 10:1 4.32 187.86
Tolfenpyrad: fluazinam 15:1 4.97 165.22
Tolfenpyrad: fluazinam 20:1 5.63 146.75
The experimental result of table 7 shows Tolfenpyrad and fluazinam composition, and 1:50~20:1 is composite in mass ratio, and oranges and tangerines resin disease (broken skin disease) is all had to synergistic effect, and when especially proportioning is between 1:50~15:1, synergy is more remarkable.

Claims (8)

1. containing a composition pesticide for Tolfenpyrad and fluazinam, comprise active component and auxiliary agent, it is characterized in that: described active component is Tolfenpyrad and fluazinam;
Described active component is counted by weight:
Tolfenpyrad 1-30 part
Fluazinam 1-60 part.
2. the composition pesticide containing Tolfenpyrad and fluazinam according to claim 1, is characterized in that: described active component is counted by weight: Tolfenpyrad 1-20 part, fluazinam 1-55 part.
3. the composition pesticide containing Tolfenpyrad and fluazinam according to claim 1, is characterized in that: described auxiliary agent comprises one or more in dispersant, emulsifier, antifreezing agent, thickener, defoamer, solvent, wetting agent, disintegrant and filler.
4. the composition pesticide containing Tolfenpyrad and fluazinam according to claim 3, is characterized in that: the parts by weight that described auxiliary agent adds are:
Dispersant 0.1-15 part
Emulsifier 0.1-12 part
Antifreezing agent 0.1-4 part
Thickener 0.1-4 part
Defoamer 0.1-2 part
Solvent 30-94.8 part
Wetting agent 0.1-15 part
Disintegrant 0.1-6 part
Filler 12-92.3 part.
5. according to the composition pesticide containing Tolfenpyrad and fluazinam described in claim 3 or 4, it is characterized in that: described emulsifier is one or more in calcium dodecyl benzene sulfonate, alkylpolyoxyethylene, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, polyoxyethylene nonylphenol ether phosphate, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether, dodecyl polyoxyethylene sulfonate sodium and phenethyl phenol polyethenoxy ether
Described solvent is one or more in dimethylbenzene, diesel oil, toluene, cyclohexanol, methyl alcohol, vegetable oil, turpentine oil, methyl oleate, solvent naphtha, dimethyl formamide, ethanol, N-pyrrolidones, ethyl acetate and aqueous solvent;
Described wetting agent is lauryl sodium sulfate, calcium dodecyl benzene sulfonate, methyl naphthalene sulfonate formaldehyde condensate, pull open one or more in powder, alkylnaphthalene sulfonate and spaonin powder;
Described dispersant is one or more in sodium lignin sulfonate, calcium lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, polycarboxylate, aliphatic amine polyoxyethylene ether and polyoxyethylene fatty acid glyceride;
Described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine and urea;
Described thickener is one or more in xanthans, Magnesiumaluminumsilicate, CMC and polyvinyl alcohol;
Described defoamer is one or more in silicone oil, C8-10 aliphatic alcohols compound and C10-20 saturated fat acid compounds;
Described disintegrant is one or more in bentonite, ammonium sulfate, sodium bicarbonate, aluminium chloride and succinic acid;
Described filler is one or more in white carbon, kaolin, diatomite, precipitated calcium carbonate and starch.
6. the composition pesticide containing Tolfenpyrad and fluazinam according to claim 5, is characterized in that: the formulation of described composition pesticide is missible oil, suspending agent, aqueous emulsion, water dispersible granules, microemulsion or wetting powder.
7. a preparation method for the composition pesticide containing Tolfenpyrad and fluazinam as described in any one in claim 1~6, is characterized in that: it is that active component and auxiliary agent are mixed by weight, can obtain by the conventional machining mode of its formulation.
8. a purposes for the composition pesticide containing Tolfenpyrad and fluazinam as described in any one in claim 1~6, is characterized in that: described composition pesticide is the application in control mandarin tree wood louse, two spotted spider mite, blister mite, aphid, resin disease, anthracnose.
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CN104365608A (en) * 2014-10-30 2015-02-25 柳州市惠农化工有限公司 Fluazinam and tolfenpyrad containing insecticide composition
CN104920351A (en) * 2015-06-23 2015-09-23 中化化工科学技术研究总院 Emulsifier special for pesticide emulsifiable concentrates
CN111436448A (en) * 2020-05-20 2020-07-24 柳州市惠农化工有限公司 Composition of spirotetramat and tolfenpyrad as well as preparation method and application thereof

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